HRP20120743T1 - Novi biomarker za nadzor razvoja bolesti i procjenu uäśinkovitosti lijeäśenja - Google Patents
Novi biomarker za nadzor razvoja bolesti i procjenu uäśinkovitosti lijeäśenja Download PDFInfo
- Publication number
- HRP20120743T1 HRP20120743T1 HRP20120743AT HRP20120743T HRP20120743T1 HR P20120743 T1 HRP20120743 T1 HR P20120743T1 HR P20120743A T HRP20120743A T HR P20120743AT HR P20120743 T HRP20120743 T HR P20120743T HR P20120743 T1 HRP20120743 T1 HR P20120743T1
- Authority
- HR
- Croatia
- Prior art keywords
- disease
- inflammatory
- development
- therapies
- assessing
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 7
- 239000000090 biomarker Substances 0.000 title claims 2
- 238000012544 monitoring process Methods 0.000 title claims 2
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 102100022464 5'-nucleotidase Human genes 0.000 claims 4
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 208000034486 Multi-organ failure Diseases 0.000 claims 2
- 208000010718 Multiple Organ Failure Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 2
- 206010069351 acute lung injury Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims 2
- 206010061818 Disease progression Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000005750 disease progression Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 208000037816 tissue injury Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
- G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
Claims (3)
1. Postupak za nadzor razvoja bolesti kod pacijenta, pri čemu je navedena bolest odabrana iz skupine koja sadrži
a) ozljedu tkiva,
b) reperfuzijsku ozljedu koja proizlazi iz infarkta miokarda ili moždanog udara, transplantacije organa ili druge kirurške operacije,
c) rak ili metastaze raka, te
d) upalno stanje,
i naznačen time da se kao biomarker koristi CD73 u tjelesnom fluidu uzetom od navedenog pacijenta, pri čemu se postupak ponavlja u dvije ili više vremenskih točaka, te se za indikaciju razvoja bolesti ili za naznaku povlačenja bolesti koristi izmijenjena razina CD73 u uzorku, koja se uspoređuje sa prethodnim testom, , pri čemu povećana razina CD73 naznačuje povlačenje bolesti, a snižena razina CD73 naznačuje razvoj bolesti.
2. Postupak prema zahtjevu 1 naznačen time da bolest je upalna bolest.
3. Postupak prema zahtjevu 2 naznačen time da upalna bolest je sindrom sistemskog upalnog odgovora (SIRS), akutna ozljeda pluća (ALI), višestruko zatajenje organa (MOF), ishemijska reperfuzijska ozljeda (DRI) ili teška reakcija na lijek (ADRS).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20070795A FI20070795A0 (fi) | 2007-10-24 | 2007-10-24 | Uusi biomarkkeri sairauksien kehittämisen tarkkailuun ja terapioiden tehon arviointiin |
| PCT/FI2008/050576 WO2009053523A1 (en) | 2007-10-24 | 2008-10-15 | A new biomarker for monitoring development of diseases and assessing the efficacy of therapies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120743T1 true HRP20120743T1 (hr) | 2012-10-31 |
Family
ID=38656804
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120743AT HRP20120743T1 (hr) | 2007-10-24 | 2012-09-18 | Novi biomarker za nadzor razvoja bolesti i procjenu uäśinkovitosti lijeäśenja |
| HRP20150181TT HRP20150181T1 (hr) | 2007-10-24 | 2015-02-16 | Cd73 kao biomarker za praä†enje razvoja bolesti i procjenu uäśinkovitosti lijeäśenja |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150181TT HRP20150181T1 (hr) | 2007-10-24 | 2015-02-16 | Cd73 kao biomarker za praä†enje razvoja bolesti i procjenu uäśinkovitosti lijeäśenja |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100209942A1 (hr) |
| EP (2) | EP2503338B1 (hr) |
| JP (2) | JP4982610B2 (hr) |
| KR (2) | KR20100059902A (hr) |
| CA (1) | CA2702635A1 (hr) |
| CY (2) | CY1113403T1 (hr) |
| DK (2) | DK2201376T3 (hr) |
| ES (2) | ES2389751T3 (hr) |
| FI (1) | FI20070795A0 (hr) |
| HR (2) | HRP20120743T1 (hr) |
| PL (2) | PL2201376T3 (hr) |
| PT (2) | PT2503338E (hr) |
| SI (2) | SI2201376T1 (hr) |
| WO (1) | WO2009053523A1 (hr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200091961A (ko) | 2008-01-18 | 2020-07-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 체액 내에서 질병 또는 병태의 시그너쳐의 검출 방법 |
| MX361944B (es) | 2010-07-23 | 2018-12-19 | President And Fellows Of Harvard College Star | Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales. |
| EP2596353A4 (en) | 2010-07-23 | 2014-01-15 | Harvard College | METHOD FOR DETECTING PRENATAL OR PREGNANT DISEASES OR SUFFERING |
| AU2011281012A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting cardiovascular diseases or conditions |
| CA2806293A1 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| KR20130041962A (ko) | 2010-07-23 | 2013-04-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 식작용 세포를 사용하여 질환 또는 상태를 검출하는 방법 |
| EA201590024A1 (ru) | 2012-06-15 | 2015-05-29 | Гарри Стилли | Способы определения заболеваний или состояний с применением циркулирующих болезненных клеток |
| MX2014015425A (es) | 2012-06-15 | 2015-07-14 | Harry Stylli | Metodos para detectar enfermedades o condiciones. |
| HUE038959T2 (hu) * | 2013-02-14 | 2018-12-28 | Faron Pharmaceuticals Oy | Eljárás akut légúti distressz szindrómával (ARDS) összefüggõ biomarkerek kimutatására, illetve eljárás az ARDS betegben történõ kifejlõdésének és kezelésének monitorozására |
| EP4202441A3 (en) | 2013-03-09 | 2023-07-26 | Immunis.AI, Inc. | Gene expression profile in macrophages for the diagnosis of cancer |
| EP2965086A4 (en) | 2013-03-09 | 2017-02-08 | Harry Stylli | Methods of detecting prostate cancer |
| EP4075139B1 (en) | 2014-09-11 | 2024-05-22 | Immunis.AI, Inc. | Methods of detecting prostate cancer |
| SI3221346T1 (sl) | 2014-11-21 | 2020-11-30 | Bristol-Myers Squibb Company | Protitelesa vsebujoča modificirana težko konstantna območja |
| UY36404A (es) | 2014-11-21 | 2016-06-01 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | ANTICUERPOS MONOCLONALES (Ab) COMO DETECTORES DE CD73 E INHIBIDORES DE SU ACTIVIDAD ENZIMÁTICA, Y COMPOSICIONES QUE LOS CONTIENEN |
| GB201706747D0 (en) * | 2017-04-27 | 2017-06-14 | Queen Mary | Method and apparatus for determining the efficacy of statins for treating inflammatory diseases in idividual patients |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU727445B2 (en) * | 1995-08-18 | 2000-12-14 | Donald W Landry | Detection of organic compounds through regulation of antibody-catalyzed reactions |
| WO1997013875A1 (en) * | 1995-10-13 | 1997-04-17 | Imperial College Of Science, Technology & Medicine | Methods for predicting the outcome of persistent hbv infection and the outcome of cytokine therapy |
| HUP0002003A3 (en) * | 2000-05-24 | 2003-01-28 | Pronuk Biotechnologia Kft | Process and reagent-kit for determining of 5'-nucleotidase activity |
| JP2005503765A (ja) * | 2001-03-27 | 2005-02-10 | ザイモジェネティクス，インコーポレイティド | ヒトサイトカイン受容体 |
| WO2004079013A1 (en) * | 2003-03-03 | 2004-09-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Ecto-5’-nucleotidase (cd73) used in the diagnosis and the treatment of pancreatic cancer |
| FI20030467A0 (fi) * | 2003-03-28 | 2003-03-28 | Sirpa Jalkanen | Menetelmä tulehdustilojen hoitamiseen |
| EP1608400B1 (en) * | 2003-03-28 | 2010-06-23 | Faron Pharmaceuticals OY | Elevation of adenosine level by cytokine-induced expression of cd73 |
| WO2005000860A2 (en) * | 2003-06-03 | 2005-01-06 | The Regents Of The University Of California | Compositions and methods for treatment of disease with acetylated disaccharides |
| JP2009505658A (ja) * | 2005-08-24 | 2009-02-12 | ブリストル−マイヤーズ スクイブ カンパニー | 上皮増殖因子受容体モデュレーターに対する感受性を決定するためのバイオマーカーおよび方法 |
| FI20051003A0 (fi) | 2005-10-07 | 2005-10-07 | Faron Pharmaceuticals Oy | Menetelmä iskemiareperfuusiovaurion tai monielinhäiriön hoitamiseksi tai estämiseksi |
| US20100048501A1 (en) * | 2006-03-21 | 2010-02-25 | Heinrich-Heine-Universitat Dusseldorf | Phosphorylated A2A Receptor Agonists |
| WO2008008284A2 (en) * | 2006-07-14 | 2008-01-17 | The Regents Of The University Of California | Cancer biomarkers and methods of use threof |
-
2007
- 2007-10-24 FI FI20070795A patent/FI20070795A0/fi not_active Application Discontinuation
-
2008
- 2008-10-15 US US12/679,785 patent/US20100209942A1/en not_active Abandoned
- 2008-10-15 EP EP12002502.8A patent/EP2503338B1/en active Active
- 2008-10-15 PL PL08842581T patent/PL2201376T3/pl unknown
- 2008-10-15 CA CA2702635A patent/CA2702635A1/en not_active Abandoned
- 2008-10-15 PT PT12002502T patent/PT2503338E/pt unknown
- 2008-10-15 ES ES08842581T patent/ES2389751T3/es active Active
- 2008-10-15 PL PL12002502T patent/PL2503338T3/pl unknown
- 2008-10-15 DK DK08842581.4T patent/DK2201376T3/da active
- 2008-10-15 JP JP2010530497A patent/JP4982610B2/ja active Active
- 2008-10-15 DK DK12002502T patent/DK2503338T3/en active
- 2008-10-15 SI SI200830723T patent/SI2201376T1/sl unknown
- 2008-10-15 ES ES12002502.8T patent/ES2532361T3/es active Active
- 2008-10-15 PT PT08842581T patent/PT2201376E/pt unknown
- 2008-10-15 WO PCT/FI2008/050576 patent/WO2009053523A1/en active Application Filing
- 2008-10-15 EP EP08842581A patent/EP2201376B1/en active Active
- 2008-10-15 KR KR1020107006430A patent/KR20100059902A/ko not_active Application Discontinuation
- 2008-10-15 SI SI200831377T patent/SI2503338T1/sl unknown
- 2008-10-15 KR KR1020167005473A patent/KR20160029869A/ko not_active Application Discontinuation
-
2012
- 2012-04-23 JP JP2012098081A patent/JP5619810B2/ja active Active
- 2012-09-18 HR HRP20120743AT patent/HRP20120743T1/hr unknown
- 2012-10-04 CY CY20121100924T patent/CY1113403T1/el unknown
-
2015
- 2015-02-16 HR HRP20150181TT patent/HRP20150181T1/hr unknown
- 2015-03-06 CY CY20151100234T patent/CY1116089T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20160029869A (ko) | 2016-03-15 |
| JP2011501176A (ja) | 2011-01-06 |
| PT2201376E (pt) | 2012-08-20 |
| EP2201376A4 (en) | 2011-03-23 |
| PL2503338T3 (pl) | 2015-06-30 |
| EP2503338A3 (en) | 2013-03-13 |
| CY1116089T1 (el) | 2017-02-08 |
| EP2503338A2 (en) | 2012-09-26 |
| CA2702635A1 (en) | 2009-04-30 |
| JP2012159514A (ja) | 2012-08-23 |
| HRP20150181T1 (hr) | 2015-06-19 |
| EP2201376B1 (en) | 2012-08-08 |
| JP5619810B2 (ja) | 2014-11-05 |
| WO2009053523A1 (en) | 2009-04-30 |
| DK2201376T3 (da) | 2012-10-15 |
| SI2503338T1 (sl) | 2015-06-30 |
| ES2389751T3 (es) | 2012-10-31 |
| SI2201376T1 (sl) | 2012-09-28 |
| US20100209942A1 (en) | 2010-08-19 |
| PT2503338E (pt) | 2015-03-05 |
| EP2201376A1 (en) | 2010-06-30 |
| EP2503338B1 (en) | 2014-12-24 |
| CY1113403T1 (el) | 2016-06-22 |
| JP4982610B2 (ja) | 2012-07-25 |
| DK2503338T3 (en) | 2015-03-09 |
| PL2201376T3 (pl) | 2013-01-31 |
| KR20100059902A (ko) | 2010-06-04 |
| ES2532361T3 (es) | 2015-03-26 |
| FI20070795A0 (fi) | 2007-10-24 |
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