JP2008514209A5 - - Google Patents
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- Publication number
- JP2008514209A5 JP2008514209A5 JP2007533908A JP2007533908A JP2008514209A5 JP 2008514209 A5 JP2008514209 A5 JP 2008514209A5 JP 2007533908 A JP2007533908 A JP 2007533908A JP 2007533908 A JP2007533908 A JP 2007533908A JP 2008514209 A5 JP2008514209 A5 JP 2008514209A5
- Authority
- JP
- Japan
- Prior art keywords
- numb
- cancer
- patient
- sample
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 101150103927 Numb gene Proteins 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 13
- 102000014736 Notch Human genes 0.000 claims 9
- 108010070047 Notch Receptors Proteins 0.000 claims 9
- 230000014509 gene expression Effects 0.000 claims 9
- 239000000523 sample Substances 0.000 claims 8
- 230000009870 specific binding Effects 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 239000000538 analytical sample Substances 0.000 claims 4
- 239000013068 control sample Substances 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 238000012360 testing method Methods 0.000 claims 4
- 238000003745 diagnosis Methods 0.000 claims 3
- 238000004393 prognosis Methods 0.000 claims 3
- 230000015556 catabolic process Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 102000015694 estrogen receptors Human genes 0.000 claims 2
- 108010038795 estrogen receptors Proteins 0.000 claims 2
- 238000011156 evaluation Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 101150044894 ER gene Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0421838.4A GB0421838D0 (en) | 2004-09-30 | 2004-09-30 | Cancer markers |
| PCT/EP2005/010153 WO2006037462A2 (en) | 2004-09-30 | 2005-09-20 | Cancer markers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514209A JP2008514209A (ja) | 2008-05-08 |
| JP2008514209A5 true JP2008514209A5 (enExample) | 2008-10-16 |
Family
ID=33427903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533908A Pending JP2008514209A (ja) | 2004-09-30 | 2005-09-20 | 癌マーカー |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7901876B2 (enExample) |
| EP (2) | EP2249155A3 (enExample) |
| JP (1) | JP2008514209A (enExample) |
| AU (1) | AU2005291613A1 (enExample) |
| CA (1) | CA2581041A1 (enExample) |
| GB (1) | GB0421838D0 (enExample) |
| WO (1) | WO2006037462A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US8747867B2 (en) | 2004-09-30 | 2014-06-10 | Ifom Fondazione Instituto Firc Di Oncologia Molecolare | Cancer markers |
| PL2032166T3 (pl) * | 2006-06-13 | 2013-09-30 | Oncomed Pharm Inc | Kompozycje i sposoby diagnozowania i leczenia nowotworów |
| EP2106439B1 (en) | 2007-01-24 | 2014-11-12 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| JP5618544B2 (ja) | 2007-01-24 | 2014-11-05 | オンコメッドファーマシューティカルズ インコーポレイテッド | 癌の診断および処置のための組成物および方法 |
| US20090208491A1 (en) * | 2007-02-14 | 2009-08-20 | Austin Gurney | Compositions and Methods for Diagnosing and Treating Cancer |
| EP2134356A2 (en) * | 2007-03-05 | 2009-12-23 | Board of Regents, The University of Texas System | Negative genetic regulation of cancer cell renewal in synergy with notch- or numb-specific immunotherapy |
| US8119366B2 (en) | 2007-10-05 | 2012-02-21 | Trojan Technologies, Ltd. | Antennapedia-dominant negative mastermind-like construct |
| CN102316897B (zh) | 2008-07-08 | 2014-11-05 | 昂考梅德药品有限公司 | Notch结合剂和拮抗剂及其应用方法 |
| US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| US8834875B2 (en) | 2010-01-13 | 2014-09-16 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| US9173963B2 (en) | 2009-05-14 | 2015-11-03 | Duke University | Diagnostic and treatment for chronic and acute phase myeloid leukemia |
| WO2013155077A1 (en) * | 2012-04-09 | 2013-10-17 | Board Of Regents,The University Of Texas System | Response markers for src inhibitor therapies |
| CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| JP6960224B2 (ja) * | 2015-01-22 | 2021-11-05 | コニカミノルタ株式会社 | 生体物質定量方法、病理診断支援システム及びプログラム |
| CN109266740A (zh) * | 2017-07-14 | 2019-01-25 | 中国科学院上海生命科学研究院 | 用于肺癌诊断或预后的标志物及诊断试剂 |
| CN114606320B (zh) * | 2022-04-13 | 2023-06-16 | 重庆医科大学 | 生物标志物epn3在制备诊断或评估肺癌的产品中的应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984001031A1 (en) | 1982-08-27 | 1984-03-15 | Roger Philip Ekins | Measurement of analyte concentration |
| WO1988001058A1 (en) | 1986-08-06 | 1988-02-11 | Roger Philip Ekins | Determination of analyte concentration using two labelling markers |
| GB8803000D0 (en) | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| WO1993008472A1 (en) | 1991-10-15 | 1993-04-29 | Multilyte Limited | Binding assay employing labelled reagent |
| GB9326450D0 (en) | 1993-12-24 | 1994-02-23 | Multilyte Ltd | Binding assay |
| GB9326451D0 (en) | 1993-12-24 | 1994-02-23 | Multilyte Ltd | Binding assay |
| GB9404709D0 (en) | 1994-03-11 | 1994-04-27 | Multilyte Ltd | Binding assay |
| GB9815799D0 (en) | 1998-07-21 | 1998-09-16 | Pharmagene Lab Limited | Quantitative analysis of gene expression |
| EP1117778A2 (en) * | 1998-10-02 | 2001-07-25 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Methods and compositions for inducing differentiation and apoptosis in cells that overexpress the notch protein |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| FR2818747B1 (fr) * | 2000-12-26 | 2003-05-16 | Molecular Engines Laboratoires | Procede de criblage base sur l'interaction siah-numb |
| DK1410011T3 (da) | 2001-06-18 | 2011-07-18 | Netherlands Cancer Inst | Diagnose og prognose for brystcancerpatienter |
| US7171311B2 (en) | 2001-06-18 | 2007-01-30 | Rosetta Inpharmatics Llc | Methods of assigning treatment to breast cancer patients |
| EP1410018A1 (en) * | 2001-07-25 | 2004-04-21 | Lorantis Limited | Method for detecting modultators of notch signalling |
| JP2005526701A (ja) * | 2001-11-14 | 2005-09-08 | ロランティス リミテッド | 内科療法 |
| US20060051755A1 (en) | 2002-04-15 | 2006-03-09 | Rigel Pharmaceuticals | Methods of assaying for cell cycle modulators |
| US20050272061A1 (en) | 2004-02-19 | 2005-12-08 | Seattle Genetics, Inc. | Expression profiling in non-small cell lung cancer |
| US7837993B2 (en) * | 2004-03-19 | 2010-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for regeneration of aged skeletal muscle tissues |
| EP1794593A2 (en) * | 2004-09-21 | 2007-06-13 | Matritech, Inc. | Methods and compositions for detecting cancer using components of the u2 spliceosomal particle |
| WO2006138275A2 (en) | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
-
2004
- 2004-09-30 GB GBGB0421838.4A patent/GB0421838D0/en not_active Ceased
-
2005
- 2005-09-20 WO PCT/EP2005/010153 patent/WO2006037462A2/en not_active Ceased
- 2005-09-20 JP JP2007533908A patent/JP2008514209A/ja active Pending
- 2005-09-20 EP EP10006758A patent/EP2249155A3/en not_active Withdrawn
- 2005-09-20 US US11/664,137 patent/US7901876B2/en not_active Expired - Fee Related
- 2005-09-20 EP EP05787481A patent/EP1802971A2/en not_active Withdrawn
- 2005-09-20 CA CA002581041A patent/CA2581041A1/en not_active Abandoned
- 2005-09-20 AU AU2005291613A patent/AU2005291613A1/en not_active Abandoned
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