KR20100046188A - 지방간을 치료하기 위한 실로스타졸을 포함하는 카르보스티릴 유도체 - Google Patents

지방간을 치료하기 위한 실로스타졸을 포함하는 카르보스티릴 유도체 Download PDF

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Publication number
KR20100046188A
KR20100046188A KR1020107002982A KR20107002982A KR20100046188A KR 20100046188 A KR20100046188 A KR 20100046188A KR 1020107002982 A KR1020107002982 A KR 1020107002982A KR 20107002982 A KR20107002982 A KR 20107002982A KR 20100046188 A KR20100046188 A KR 20100046188A
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KR
South Korea
Prior art keywords
fatty liver
liver
cilostazol
carbostyryl
formula
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Abandoned
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KR1020107002982A
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English (en)
Korean (ko)
Inventor
아쯔시 나까지마
고지 후지따
마사또 요네다
오사무 무께다
다까꼬 이찌무라
Original Assignee
오츠카 세이야쿠 가부시키가이샤
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Publication of KR20100046188A publication Critical patent/KR20100046188A/ko
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020107002982A 2007-07-11 2008-07-09 지방간을 치료하기 위한 실로스타졸을 포함하는 카르보스티릴 유도체 Abandoned KR20100046188A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007181760 2007-07-11
JPJP-P-2007-181760 2007-07-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR20157007589A Division KR20150038739A (ko) 2007-07-11 2008-07-09 지방간을 치료하기 위한 실로스타졸을 포함하는 카르보스티릴 유도체

Publications (1)

Publication Number Publication Date
KR20100046188A true KR20100046188A (ko) 2010-05-06

Family

ID=39689465

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020107002982A Abandoned KR20100046188A (ko) 2007-07-11 2008-07-09 지방간을 치료하기 위한 실로스타졸을 포함하는 카르보스티릴 유도체
KR20157007589A Ceased KR20150038739A (ko) 2007-07-11 2008-07-09 지방간을 치료하기 위한 실로스타졸을 포함하는 카르보스티릴 유도체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR20157007589A Ceased KR20150038739A (ko) 2007-07-11 2008-07-09 지방간을 치료하기 위한 실로스타졸을 포함하는 카르보스티릴 유도체

Country Status (9)

Country Link
US (2) US8642618B2 (https=)
EP (1) EP2162134A1 (https=)
JP (2) JP5558348B2 (https=)
KR (2) KR20100046188A (https=)
CN (1) CN101778630A (https=)
AR (1) AR067446A1 (https=)
CA (1) CA2691632A1 (https=)
TW (1) TW200908973A (https=)
WO (1) WO2009008539A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101094934B1 (ko) * 2010-10-22 2011-12-15 영남대학교 산학협력단 실로스타졸을 유효성분으로 함유하는 알코올성 간질환 치료 또는 예방용 약학조성물
EP3263705A1 (en) * 2016-06-28 2018-01-03 DKFZ Deutsches Krebsforschungszentrum Treatments of non-alcoholic steatohepatitis (nash)
US11207387B2 (en) 2016-12-15 2021-12-28 Talengen International Limited Method and drug for preventing and treating obesity
WO2018107688A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种预防和治疗脂肪肝的方法
WO2018107707A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种改善心脏病变的方法
CA3212293A1 (en) * 2021-05-11 2022-11-17 Regeneron Pharmaceuticals, Inc. Methods of treating liver diseases with phosphodiesterase 3b (pde3b) inhibitors
JP2024531507A (ja) * 2021-08-31 2024-08-29 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｃａｍｐ応答性エレメント結合タンパク質３様３（ｃｒｅｂ３ｌ３）阻害剤による肝疾患の治療

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3944257B2 (ja) 1995-12-07 2007-07-11 大塚製薬株式会社 肝実質細胞増殖因子産生増加剤

Also Published As

Publication number Publication date
TW200908973A (en) 2009-03-01
EP2162134A1 (en) 2010-03-17
JP2010533166A (ja) 2010-10-21
CN101778630A (zh) 2010-07-14
JP2014185161A (ja) 2014-10-02
KR20150038739A (ko) 2015-04-08
US8642618B2 (en) 2014-02-04
WO2009008539A1 (en) 2009-01-15
US20140121241A1 (en) 2014-05-01
US20110039887A1 (en) 2011-02-17
JP5558348B2 (ja) 2014-07-23
AR067446A1 (es) 2009-10-14
CA2691632A1 (en) 2009-01-15

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