KR20090101146A - 저장안정성이 우수한 파클리탁셀 함유 주사제 조성물의 제조방법 - Google Patents
저장안정성이 우수한 파클리탁셀 함유 주사제 조성물의 제조방법 Download PDFInfo
- Publication number
- KR20090101146A KR20090101146A KR1020090079338A KR20090079338A KR20090101146A KR 20090101146 A KR20090101146 A KR 20090101146A KR 1020090079338 A KR1020090079338 A KR 1020090079338A KR 20090079338 A KR20090079338 A KR 20090079338A KR 20090101146 A KR20090101146 A KR 20090101146A
- Authority
- KR
- South Korea
- Prior art keywords
- paclitaxel
- cyclodextrin
- solution
- polyvinylpyrrolidone
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
구분 | 제조 농도 (㎎/㎖) | 초기 농도 (㎎/㎖) | 48시간 후 농도(㎎/㎖) | 96시간 후 농도(㎎/㎖) | 96시간 후 용액 변화 |
실시예 1 | 1.70 | 1.69 | 1.69 | 1.67 | clear solution |
실시예 2 | 3.00 | 2.99 | 2.94 | 2.82 | clear solution |
실시예 3 | 3.01 | 2.98 | 2.92 | 2.80 | clear solution |
비교예 1 | 1.00 | 0.98 | 0.45 | 0.34 | precipitation |
Claims (8)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20060049833 | 2006-06-02 | ||
KR1020060049833 | 2006-06-02 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020070054058A Division KR100917810B1 (ko) | 2006-06-02 | 2007-06-01 | 저장안정성이 우수한 파클리탁셀 함유 주사제 조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20090101146A true KR20090101146A (ko) | 2009-09-24 |
KR100983377B1 KR100983377B1 (ko) | 2010-09-20 |
Family
ID=39142033
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020070054058A KR100917810B1 (ko) | 2006-06-02 | 2007-06-01 | 저장안정성이 우수한 파클리탁셀 함유 주사제 조성물 |
KR1020090079338A KR100983377B1 (ko) | 2006-06-02 | 2009-08-26 | 저장안정성이 우수한 파클리탁셀 함유 주사제 조성물의 제조방법 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020070054058A KR100917810B1 (ko) | 2006-06-02 | 2007-06-01 | 저장안정성이 우수한 파클리탁셀 함유 주사제 조성물 |
Country Status (1)
Country | Link |
---|---|
KR (2) | KR100917810B1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101478779B1 (ko) * | 2007-11-22 | 2015-01-05 | 에스케이케미칼주식회사 | 재수화시간이 향상된 택산 유도체 함유 동결건조 조성물 및이의 제조방법 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP9701945A3 (en) * | 1997-11-10 | 2000-04-28 | Hexal Ag | Pharmaceutical composition for injection containing cyclodextrin and taxoids |
KR100310839B1 (ko) * | 1999-03-23 | 2001-10-12 | 정기련 | 안정성이 개선된 파크리탁셀 가용화 주사제 조성물 |
KR20030041577A (ko) * | 2001-11-20 | 2003-05-27 | 디디에스텍주식회사 | 난용성 약물과 치환된 시클로덱스트린을 함유하는고체분산체 및 이를 함유하는 약제학적 조성물 |
JP2003342168A (ja) * | 2002-05-24 | 2003-12-03 | Nano Career Kk | 注射用薬物含有ポリマーミセル製剤の製造方法 |
-
2007
- 2007-06-01 KR KR1020070054058A patent/KR100917810B1/ko active IP Right Grant
-
2009
- 2009-08-26 KR KR1020090079338A patent/KR100983377B1/ko active IP Right Grant
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101478779B1 (ko) * | 2007-11-22 | 2015-01-05 | 에스케이케미칼주식회사 | 재수화시간이 향상된 택산 유도체 함유 동결건조 조성물 및이의 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
KR20070115796A (ko) | 2007-12-06 |
KR100917810B1 (ko) | 2009-09-18 |
KR100983377B1 (ko) | 2010-09-20 |
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