KR20090082453A - 야누스 키나제의 억제제로서 유용한 트리사이클릭 헤테로아릴 화합물 - Google Patents

야누스 키나제의 억제제로서 유용한 트리사이클릭 헤테로아릴 화합물 Download PDF

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Publication number
KR20090082453A
KR20090082453A KR1020097011345A KR20097011345A KR20090082453A KR 20090082453 A KR20090082453 A KR 20090082453A KR 1020097011345 A KR1020097011345 A KR 1020097011345A KR 20097011345 A KR20097011345 A KR 20097011345A KR 20090082453 A KR20090082453 A KR 20090082453A
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South Korea
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aliphatic
compound
membered
optionally substituted
heteroaryl
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Korean (ko)
Inventor
유세프 벤나니
톈성 왕
프란세스코 살리투로
존 더피
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버텍스 파마슈티칼스 인코포레이티드
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Publication of KR20090082453A publication Critical patent/KR20090082453A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
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  • Diabetes (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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KR1020097011345A 2006-11-01 2007-10-31 야누스 키나제의 억제제로서 유용한 트리사이클릭 헤테로아릴 화합물 Withdrawn KR20090082453A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85586206P 2006-11-01 2006-11-01
US60/855,862 2006-11-01

Publications (1)

Publication Number Publication Date
KR20090082453A true KR20090082453A (ko) 2009-07-30

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KR1020097011345A Withdrawn KR20090082453A (ko) 2006-11-01 2007-10-31 야누스 키나제의 억제제로서 유용한 트리사이클릭 헤테로아릴 화합물

Country Status (12)

Country Link
US (3) US8163732B2 (enExample)
EP (1) EP2079740B1 (enExample)
JP (1) JP2010508363A (enExample)
KR (1) KR20090082453A (enExample)
CN (1) CN101568540A (enExample)
AU (1) AU2007338574A1 (enExample)
CA (1) CA2668159A1 (enExample)
IL (1) IL198510A0 (enExample)
MX (1) MX2009004771A (enExample)
NO (1) NO20092130L (enExample)
RU (1) RU2009120622A (enExample)
WO (1) WO2008079521A2 (enExample)

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WO2012078802A1 (en) * 2010-12-08 2012-06-14 Takeda Pharmaceutical Company Limited PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES
WO2012085176A1 (en) * 2010-12-23 2012-06-28 F. Hoffmann-La Roche Ag Tricyclic pyrazinone compounds, compositions and methods of use thereof as janus kinase inhibitors
US10821111B2 (en) 2011-11-30 2020-11-03 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
EP2785184B1 (en) * 2011-11-30 2020-06-10 Emory University Compositions comprising jak inhibitors and haart drugs for use in the prevention or treatment of hiv
WO2014013014A1 (en) 2012-07-18 2014-01-23 Fundació Privada Centre De Regulació Genòmica (Crg) Jak inhibitors for activation of epidermal stem cell populations
JP6419735B2 (ja) * 2013-03-12 2018-11-07 アッヴィ・インコーポレイテッド 四環系ブロモドメイン阻害剤
CN105636962B (zh) * 2013-10-15 2017-10-13 靳博涵 新型化合物、用途及其制备方法
WO2015119712A1 (en) * 2014-02-06 2015-08-13 Abbvie Inc. Tetracyclic cdk9 kinase inhibitors
WO2016004305A2 (en) 2014-07-02 2016-01-07 Pharmacyclics Llc Inhibitors of bruton's tyrosine kinase
WO2018041989A1 (en) 2016-09-02 2018-03-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating refractory celiac disease type 2
EP3628044B1 (en) * 2017-05-15 2023-11-22 The Regents of The University of Michigan Pyrrolo[2,3-c]pyridines and related analogs as lsd-1 inhibitors
US20220177978A1 (en) 2019-04-02 2022-06-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
EP3955920A1 (en) 2019-04-16 2022-02-23 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels
EP4526469A1 (en) 2022-05-16 2025-03-26 Institut National de la Santé et de la Recherche Médicale Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation

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EP2079740A2 (en) 2009-07-22
AU2007338574A1 (en) 2008-07-03
MX2009004771A (es) 2009-06-17
JP2010508363A (ja) 2010-03-18
EP2079740B1 (en) 2012-12-05
CN101568540A (zh) 2009-10-28
RU2009120622A (ru) 2010-12-10
US8163732B2 (en) 2012-04-24
WO2008079521A3 (en) 2008-10-09
US20130090331A1 (en) 2013-04-11
IL198510A0 (en) 2010-02-17
NO20092130L (no) 2009-06-17
CA2668159A1 (en) 2008-07-03
US20100081645A1 (en) 2010-04-01
WO2008079521A2 (en) 2008-07-03

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