KR20090060314A - 5-치환 이소인돌린 화합물 - Google Patents
5-치환 이소인돌린 화합물 Download PDFInfo
- Publication number
- KR20090060314A KR20090060314A KR1020097006325A KR20097006325A KR20090060314A KR 20090060314 A KR20090060314 A KR 20090060314A KR 1020097006325 A KR1020097006325 A KR 1020097006325A KR 20097006325 A KR20097006325 A KR 20097006325A KR 20090060314 A KR20090060314 A KR 20090060314A
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- KR
- South Korea
- Prior art keywords
- alkyl
- stereoisomer
- pharmaceutically acceptable
- compound
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 5-substituted isoindolin compounds Chemical class 0.000 title claims description 139
- 150000001875 compounds Chemical class 0.000 claims abstract description 125
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 36
- 125000003118 aryl group Chemical group 0.000 claims description 36
- 125000005843 halogen group Chemical group 0.000 claims description 33
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- 125000001424 substituent group Chemical group 0.000 claims description 17
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 14
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 5
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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Applications Claiming Priority (6)
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| US84136506P | 2006-08-30 | 2006-08-30 | |
| US60/841,365 | 2006-08-30 | ||
| US92551307P | 2007-04-20 | 2007-04-20 | |
| US60/925,513 | 2007-04-20 | ||
| US93778207P | 2007-06-28 | 2007-06-28 | |
| US60/937,782 | 2007-06-28 |
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| KR20090060314A true KR20090060314A (ko) | 2009-06-11 |
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| KR20220080003A (ko) * | 2020-09-23 | 2022-06-14 | 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 | 세레브론 단백질의 조절제로서의 치환된 n-(2-(2,6-디옥소피페리딘-3-일)-1,3-디옥소이소인돌린-5-일)아릴설폰아미드 유사체 |
| WO2024215130A1 (en) * | 2023-04-13 | 2024-10-17 | Cyrus Therapeutics Inc. | Novel gspt1 degrader and use thereof |
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- 2007-08-29 KR KR1020097006325A patent/KR20090060314A/ko not_active Withdrawn
- 2007-08-29 NZ NZ575061A patent/NZ575061A/en not_active IP Right Cessation
- 2007-08-29 BR BRPI0716092-5A2A patent/BRPI0716092A2/pt not_active IP Right Cessation
- 2007-08-29 CL CL200702513A patent/CL2007002513A1/es unknown
- 2007-08-29 AU AU2007290407A patent/AU2007290407A1/en not_active Abandoned
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| KR20170036698A (ko) * | 2014-07-11 | 2017-04-03 | 셀진 코포레이션 | 항증식성 화합물 및 이의 사용 방법 |
| KR20220080003A (ko) * | 2020-09-23 | 2022-06-14 | 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 | 세레브론 단백질의 조절제로서의 치환된 n-(2-(2,6-디옥소피페리딘-3-일)-1,3-디옥소이소인돌린-5-일)아릴설폰아미드 유사체 |
| US12454519B2 (en) | 2020-09-23 | 2025-10-28 | St. Jude Children's Research Hospital, Inc. | Substituted N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein |
| US12454518B2 (en) | 2020-09-23 | 2025-10-28 | St. Jude Children's Research Hospital, Inc. | Substituted N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein |
| WO2024215130A1 (en) * | 2023-04-13 | 2024-10-17 | Cyrus Therapeutics Inc. | Novel gspt1 degrader and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| PE20080768A1 (es) | 2008-06-14 |
| IL197098A0 (en) | 2009-11-18 |
| JP2014141521A (ja) | 2014-08-07 |
| TW200817368A (en) | 2008-04-16 |
| WO2008027542A2 (en) | 2008-03-06 |
| CO6160231A2 (es) | 2010-05-20 |
| AR062606A1 (es) | 2008-11-19 |
| NZ575061A (en) | 2011-10-28 |
| EP2057143A2 (en) | 2009-05-13 |
| JP2010502627A (ja) | 2010-01-28 |
| ES2426350T3 (es) | 2013-10-22 |
| CA2660806A1 (en) | 2008-03-06 |
| CL2007002513A1 (es) | 2008-04-04 |
| EP2057143B1 (en) | 2013-07-24 |
| AU2007290407A1 (en) | 2008-03-06 |
| CA2660806C (en) | 2015-06-16 |
| JP5853047B2 (ja) | 2016-02-09 |
| BRPI0716092A2 (pt) | 2013-09-17 |
| MX2009001989A (es) | 2009-03-09 |
| WO2008027542A3 (en) | 2008-04-17 |
| CR10653A (es) | 2009-04-03 |
| JP5523831B2 (ja) | 2014-06-18 |
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