TW200817368A - 5-substituted isoindoline compounds - Google Patents

Info

Publication number

TW200817368A

TW200817368A TW096132346A TW96132346A TW200817368A TW 200817368 A TW200817368 A TW 200817368A TW 096132346 A TW096132346 A TW 096132346A TW 96132346 A TW96132346 A TW 96132346A TW 200817368 A TW200817368 A TW 200817368A

Authority

TW

Taiwan

Prior art keywords

compound

mmol

alkyl

doc

etoac

Prior art date

2006-08-30

Links

• Espacenet
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• -1 5-substituted isoindoline compounds Chemical class 0.000 title claims abstract description 118
• 150000001875 compounds Chemical class 0.000 claims abstract description 126
• 150000003839 salts Chemical class 0.000 claims abstract description 38
• 238000000034 method Methods 0.000 claims abstract description 37
• 239000012453 solvate Substances 0.000 claims abstract description 26
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 23
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 91
• 201000010099 disease Diseases 0.000 claims description 73
• 125000000217 alkyl group Chemical group 0.000 claims description 66
• 239000002552 dosage form Substances 0.000 claims description 58
• 239000013543 active substance Substances 0.000 claims description 35
• 229910052736 halogen Inorganic materials 0.000 claims description 34
• 150000002367 halogens Chemical class 0.000 claims description 31
• 208000011580 syndromic disease Diseases 0.000 claims description 28
• 125000003545 alkoxy group Chemical group 0.000 claims description 26
• 125000003118 aryl group Chemical group 0.000 claims description 26
• OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 26
• 208000002193 Pain Diseases 0.000 claims description 24
• 125000001072 heteroaryl group Chemical group 0.000 claims description 21
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
• 125000000623 heterocyclic group Chemical group 0.000 claims description 12
• 239000002775 capsule Substances 0.000 claims description 11
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• 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 6
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• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
• 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims description 2
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