KR20090035188A - 일체형 무균 캡슐 제조장치 - Google Patents
일체형 무균 캡슐 제조장치 Download PDFInfo
- Publication number
- KR20090035188A KR20090035188A KR1020070100323A KR20070100323A KR20090035188A KR 20090035188 A KR20090035188 A KR 20090035188A KR 1020070100323 A KR1020070100323 A KR 1020070100323A KR 20070100323 A KR20070100323 A KR 20070100323A KR 20090035188 A KR20090035188 A KR 20090035188A
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- capsule
- mesh
- manufacturing apparatus
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- 238000000034 method Methods 0.000 claims description 34
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- 238000004132 cross linking Methods 0.000 claims description 25
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- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
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- 239000013543 active substance Substances 0.000 description 1
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- 239000006285 cell suspension Substances 0.000 description 1
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- 229940045110 chitosan Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
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- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229940068984 polyvinyl alcohol Drugs 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
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- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/077—Manufacturing capsule shells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Engineering & Computer Science (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
Claims (12)
- 단일 용기 내에 멀티 노즐, 이중 메쉬 및 가교 용액 용기를 포함하는 일체형 무균 캡슐 제조장치.
- 제 1 항에 있어서,상기 멀티노즐이 1개 내지 150개의 압출구를 포함하는 것을 특징으로 하는 일체형 무균 캡슐 제조장치.
- 제 2 항에 있어서,상기 압출구가 18G 내지 24G 크기의 주사용 바늘인 것을 특징으로 하는 일체형 무균 캡슐 제조장치.
- 제 3 항에 있어서,상기 바늘이 노즐 밖으로 돌출된 부분이 0.3 내지 1mm이고, 바늘 측면에 구경이 1.5 내지 3mm인 구멍이 있는 것을 특징으로 하는 일체형 무균 캡슐 제조 장치.
- 제 1 항에 있어서,상기 이중 메쉬가 내부 메쉬 및 외부 메쉬로 이루어진 것을 특징으로 하는 일체형 무균 캡슐 제조장치.
- 제 5 항에 있어서,상기 내부 메쉬가 목적하는 캡슐 입경 범위의 하한을 구경(pore size)으로 하고, 외부 메쉬가 목적하는 캡슐 입경 범위의 상한을 구경으로 하는 것을 특징으로 하는 일체형 무균 캡슐 제조장치.
- 제 5 항에 있어서,내부 메쉬는 바닥이 뚫려있고, 외부 메쉬는 바닥이 막혀있는 것을 특징으로 하는 일체형 무균 캡슐 제조장치.
- 제 5 항에 있어서,상기 이중 메쉬가 가교 용액 용기 내부에 위치하는 것을 특징으로 하는 일체형 무균 캡슐 제조장치.
- 멀티노즐을 통한 캡슐 압출 단계; 가교용액 용기 내에서의 캡슐의 경화 단계; 및 내부 메쉬 및 외부 메쉬를 이용하는 캡슐의 세척 및 선별 단계를 포함하는, 제 1 항의 일체형 무균 캡슐 제조장치를 이용하여 무균 캡슐을 제조하는 방법.
- 제 9 항에 있어서,상기 단계들이 모두 4℃의 냉장 조건 하에 수행되는 것을 특징으로 하는 방법.
- 제 9 항에 있어서,상기 캡슐 압출 단계가 공기분사 방법, 진동방법 또는 정전기를 이용한 방법을 이용하여 수행되는 것을 특징으로 하는 방법.
- 제 11 항에 있어서,상기 캡슐 압출 단계가 0.02 내지 0.3 MPa의 압력 조건 하에 공기분사 방법으로 수행되는 것을 특징으로 하는 방법.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070100323A KR100902781B1 (ko) | 2007-10-05 | 2007-10-05 | 일체형 무균 캡슐 제조장치 |
CA2701598A CA2701598C (en) | 2007-10-05 | 2008-10-01 | Apparatus and method of manufacturing aseptic capsules |
CN200880109518A CN101815497A (zh) | 2007-10-05 | 2008-10-01 | 制造无菌包囊的设备和方法 |
DE112008002671.8T DE112008002671B4 (de) | 2007-10-05 | 2008-10-01 | Vorrichtung und Verfahren zum Herstellen aseptischer Kapseln |
US12/681,566 US20100219545A1 (en) | 2007-10-05 | 2008-10-01 | Apparatus and method of manufacturing aseptic capsules |
GB1006568A GB2466170A (en) | 2007-10-05 | 2008-10-01 | Apparatus and method of manufacturing aseptic capsules |
PCT/KR2008/005796 WO2009045052A1 (en) | 2007-10-05 | 2008-10-01 | Apparatus and method of manufacturing aseptic capsules |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070100323A KR100902781B1 (ko) | 2007-10-05 | 2007-10-05 | 일체형 무균 캡슐 제조장치 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20090035188A true KR20090035188A (ko) | 2009-04-09 |
KR100902781B1 KR100902781B1 (ko) | 2009-06-12 |
Family
ID=40526405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020070100323A KR100902781B1 (ko) | 2007-10-05 | 2007-10-05 | 일체형 무균 캡슐 제조장치 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20100219545A1 (ko) |
KR (1) | KR100902781B1 (ko) |
CN (1) | CN101815497A (ko) |
CA (1) | CA2701598C (ko) |
DE (1) | DE112008002671B4 (ko) |
GB (1) | GB2466170A (ko) |
WO (1) | WO2009045052A1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190081881A (ko) * | 2017-12-29 | 2019-07-09 | 아주대학교산학협력단 | 초음파 분무기를 이용한 미립구 약제의 양산 시스템 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102013012467A1 (de) * | 2013-07-26 | 2015-01-29 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verkapselungseinrichtung und -verfahren zur Verkapselung einer Probe in einer Polymerkapsel |
CN107854318A (zh) * | 2017-12-16 | 2018-03-30 | 吕丽 | 一种空心胶囊的脱模出料一体机 |
KR102089391B1 (ko) * | 2019-03-07 | 2020-04-23 | 정수영 | 약제 성형기 |
KR102249716B1 (ko) * | 2019-05-22 | 2021-05-10 | 정수영 | 약제 성형기 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60118103A (ja) * | 1983-10-25 | 1985-06-25 | プラント・ジエネテイクス・インコ−ポレ−テツド | 生物学的に活性な物質を用いるカプセル製造 |
FR2657257B1 (fr) * | 1990-01-19 | 1994-09-02 | Rhone Poulenc Sante | Procede de preparation de medicaments sous forme de perles. |
FR2665374B1 (fr) * | 1990-08-03 | 1992-12-04 | Bioetica Sa | Microcapsules a paroi mixte d'atelocollagene et de polyholosides coagulee par un cation bivalent et procede de fabrication de ces microcapsules et des compositions cosmetiques ou pharmaceutiques ou alimentaires en contenant. |
US6495161B1 (en) * | 1999-03-09 | 2002-12-17 | Vivorx, Inc. | Cytoprotective biocompatible containment systems for biologically active materials and methods of making same |
US6982095B2 (en) * | 2001-06-28 | 2006-01-03 | Morishita Jintan Co., Ltd. | Capsules containing vital cells or tissues |
US7578951B2 (en) * | 2004-01-27 | 2009-08-25 | Hewlett-Packard Development Company, L.P. | Method of making microcapsules utilizing a fluid ejector |
DE102004019241A1 (de) * | 2004-04-16 | 2005-11-03 | Cellmed Ag | Injizierbare vernetzte und unvernetzte Alginate und ihre Verwendung in der Medizin und in der ästhetischen Chirurgie |
KR100725730B1 (ko) * | 2006-08-31 | 2007-06-08 | 윤민호 | 서방성 캡슐화 미생물 비료, 및 그의 제조방법 및 장치 |
-
2007
- 2007-10-05 KR KR1020070100323A patent/KR100902781B1/ko active IP Right Grant
-
2008
- 2008-10-01 WO PCT/KR2008/005796 patent/WO2009045052A1/en active Application Filing
- 2008-10-01 CA CA2701598A patent/CA2701598C/en active Active
- 2008-10-01 GB GB1006568A patent/GB2466170A/en not_active Withdrawn
- 2008-10-01 DE DE112008002671.8T patent/DE112008002671B4/de active Active
- 2008-10-01 CN CN200880109518A patent/CN101815497A/zh active Pending
- 2008-10-01 US US12/681,566 patent/US20100219545A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190081881A (ko) * | 2017-12-29 | 2019-07-09 | 아주대학교산학협력단 | 초음파 분무기를 이용한 미립구 약제의 양산 시스템 |
Also Published As
Publication number | Publication date |
---|---|
WO2009045052A1 (en) | 2009-04-09 |
KR100902781B1 (ko) | 2009-06-12 |
CA2701598C (en) | 2014-11-18 |
CN101815497A (zh) | 2010-08-25 |
US20100219545A1 (en) | 2010-09-02 |
DE112008002671B4 (de) | 2017-06-08 |
GB201006568D0 (en) | 2010-06-02 |
CA2701598A1 (en) | 2009-04-09 |
DE112008002671T5 (de) | 2011-02-17 |
GB2466170A (en) | 2010-06-16 |
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