KR20090031314A - N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 - Google Patents
N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 Download PDFInfo
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- KR20090031314A KR20090031314A KR1020080092366A KR20080092366A KR20090031314A KR 20090031314 A KR20090031314 A KR 20090031314A KR 1020080092366 A KR1020080092366 A KR 1020080092366A KR 20080092366 A KR20080092366 A KR 20080092366A KR 20090031314 A KR20090031314 A KR 20090031314A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
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- C—CHEMISTRY; METALLURGY
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- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/08—Malonic acid
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- C07C55/02—Dicarboxylic acids
- C07C55/12—Glutaric acid
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/14—Adipic acid
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
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- Orthopedic Medicine & Surgery (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (13)
- 제1항에 있어서, 무수화물 내지 수화물 상태의 메트포르민 디카르복실산염.
- 제3항에 있어서, 화학식 1의 메트포르민 디카르복실산염이 메트포르민 (2:1) 말론산염, 메트포르민 (2:1) 글루타르산염, 메트포르민 (2:1) 아디핀산염 또는 메 트포르민 (2:1) 사과산염인 방법.
- 제3항에 있어서, 무기알칼리가 수산화나트륨 또는 수산화칼륨인 방법.
- 제4항에 있어서, 유기알칼리가 탄산칼륨인 방법.
- 제3항에 있어서, 유기용매가 테트라하이드로퓨란, 디메틸포름아마이드, 메탄올, 에탄올, 이소프로판올, 아세톤 및 아세토니트릴로 구성된 군으로부터 선택되는 방법.
- 제4항에 있어서, 유기용매가 테트라하이드로퓨란, 디메틸포름아마이드, 메탄올, 에탄올, 이소프로판올, 아세톤 및 아세토니트릴로 구성된 군으로부터 선택되는 방법.
- 제1항의 화학식 1의 메트포르민 디카르복실산염을 유효성분으로 포함하는 당뇨 및 당뇨병, 비만증, 고지혈증, 지방간, 관상 동맥 질환, 골다공증, 다낭성 난소증후군이 복합적으로 나타나는 대사성 증후군을 지닌 자들의 당뇨병 및 이의 합병증, p53 유전자가 결여된 암, 근육통, 근육세포 독성 및 횡문근 융해로부터 선택되는 1종 이상의 질환의 예방 또는 치료용 약제학적 조성물.
- 제11항에 있어서, 정제 또는 캅셀제로 제형화된 약제학적 조성물.
- 제11항 또는 제12항에 있어서, 메트포르민 유리염기로서 1일 1 내지 3회에 걸쳐 50 내지 3,000mg이 경구 투여됨을 특징으로 하는 약제학적 조성물.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20070096533 | 2007-09-21 | ||
KR20070096527 | 2007-09-21 | ||
KR1020070096533 | 2007-09-21 | ||
KR1020070096527 | 2007-09-21 | ||
KR1020080062806 | 2008-06-30 | ||
KR20080062806 | 2008-06-30 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020100101886A Division KR20100126238A (ko) | 2007-09-21 | 2010-10-19 | N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 |
KR1020100101885A Division KR20100126635A (ko) | 2007-09-21 | 2010-10-19 | N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 |
KR1020100101884A Division KR20100126237A (ko) | 2007-09-21 | 2010-10-19 | N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 |
Publications (2)
Publication Number | Publication Date |
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KR20090031314A true KR20090031314A (ko) | 2009-03-25 |
KR101226669B1 KR101226669B1 (ko) | 2013-01-25 |
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Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
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KR1020080092366A KR101226669B1 (ko) | 2007-09-21 | 2008-09-19 | N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 |
KR1020100101884A KR20100126237A (ko) | 2007-09-21 | 2010-10-19 | N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 |
KR1020100101886A KR20100126238A (ko) | 2007-09-21 | 2010-10-19 | N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 |
KR1020100101885A KR20100126635A (ko) | 2007-09-21 | 2010-10-19 | N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
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KR1020100101884A KR20100126237A (ko) | 2007-09-21 | 2010-10-19 | N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 |
KR1020100101886A KR20100126238A (ko) | 2007-09-21 | 2010-10-19 | N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 |
KR1020100101885A KR20100126635A (ko) | 2007-09-21 | 2010-10-19 | N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8076377B2 (ko) |
EP (1) | EP2203418B1 (ko) |
JP (1) | JP5292404B2 (ko) |
KR (4) | KR101226669B1 (ko) |
CN (1) | CN101855204B (ko) |
WO (1) | WO2009038396A2 (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010146604A2 (en) | 2009-06-18 | 2010-12-23 | Exemed Pharmaceuticals | Processes for preparing metformin hydrochloride |
US20120178813A1 (en) * | 2011-01-12 | 2012-07-12 | Thetis Pharmaceuticals Llc | Lipid-lowering antidiabetic agent |
US8765811B2 (en) | 2012-07-10 | 2014-07-01 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
US9382187B2 (en) | 2012-07-10 | 2016-07-05 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
CA2878819A1 (en) * | 2012-07-10 | 2014-01-16 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
US9505709B2 (en) | 2014-05-05 | 2016-11-29 | Thetis Pharmaceuticals Llc | Compositions and methods relating to ionic salts of peptides |
DK3157936T3 (en) | 2014-06-18 | 2019-02-04 | Thetis Pharmaceuticals Llc | MINERAL AMINO ACID ACID COMPLEXES OF ACTIVE SUBSTANCES |
US9242008B2 (en) | 2014-06-18 | 2016-01-26 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of fatty acids |
JP6906047B2 (ja) | 2016-06-03 | 2021-07-21 | テティス・ファーマシューティカルズ・エルエルシー | 特異的炎症収束性メディエーターの塩に関連する組成物及び方法 |
US11510886B2 (en) | 2016-09-30 | 2022-11-29 | Laboratorios Silanes, S.A. De C.V. | Metformin amino acid compounds and methods of using the same |
MX2019003725A (es) | 2016-09-30 | 2019-08-12 | Laboratorios Silanes S A De C V | Glicinato de metformina, composiciones farmaceuticas que comprenden la misma, y metodos de uso de la misma. |
CN115073331A (zh) * | 2021-03-15 | 2022-09-20 | 中国医学科学院药物研究所 | 二甲双胍肉桂酸盐一水合物及制备方法和其组合物与用途 |
CN113105367B (zh) * | 2021-03-30 | 2022-08-02 | 广州大学 | 一类二甲双胍盐及其制备方法和应用 |
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DD104782A1 (ko) | 1972-05-29 | 1974-03-20 | ||
FR2243684B1 (ko) * | 1973-09-19 | 1977-01-28 | Semb | |
US4080472A (en) | 1974-03-22 | 1978-03-21 | Societe D'etudes Et D'exploitation De Marques Et Brevets S.E.M.S. | Metformin 2-(p-chlorophenoxy)-2-methylpropionate |
CH602612A5 (ko) | 1974-10-11 | 1978-07-31 | Hoffmann La Roche | |
FR2585572B3 (fr) | 1985-07-31 | 1987-12-31 | Hugelin Andre | Nouvelles compositions pharmaceutiques a base d'un sel de l'acide p. chlorophenoxyacetique destinees au traitement des neuropathies et assurant la regeneration nerveuse |
GB8608335D0 (en) | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
US6399658B1 (en) * | 1996-12-24 | 2002-06-04 | Sumitomo Pharmaceuticals Co., Ltd. | Composition containing ascorbic acid |
CA2312990C (en) | 1997-12-08 | 2008-04-29 | Bristol-Myers Squibb Company | Novel salts of metformin and method |
EA003101B1 (ru) * | 1998-03-19 | 2002-12-26 | Бристол-Майерз Сквибб Компани | Двухфазная система доставки с регулируемым высвобождением для фармацевтических средств с высокой растворимостью и способ лечения диабета с помощью этой системы |
JP4606582B2 (ja) * | 1998-04-29 | 2011-01-05 | 大日本住友製薬株式会社 | ビグアナイド系薬物の内服製剤 |
AU2001213150A1 (en) * | 2000-08-03 | 2002-02-18 | Olga Evgenievna Kolesova | Composition of metformin with succinic acid or salts thereof and method for treating diabetes |
WO2003068209A1 (en) * | 2002-02-14 | 2003-08-21 | Sonus Pharmaceuticals, Inc. | Metformin salts of lipophilic acids |
AU2003272084A1 (en) | 2003-10-07 | 2005-04-21 | Biocon Limited | SALT OF 1,2,6,7,8,8A-HEXAHYDRO-Beta,Delta,6-TRIHYDROXY-2-METHYL-8-((2S)-2-METHYL-1-OXOBUTOXY)-, (BetaR,Delta R,1S,2S,6S,8S,8AR)- 1-NAPHTHALENEHEPTANOIC ACID WITH N,N-DIMETHYL-IMIDODICARBONIMIDIC DIAMIDE |
CN100497337C (zh) | 2006-11-20 | 2009-06-10 | 淮北辉克药业有限公司 | 叶酸二甲双胍及其制备方法 |
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2008
- 2008-09-19 JP JP2010525765A patent/JP5292404B2/ja not_active Expired - Fee Related
- 2008-09-19 EP EP08832662.4A patent/EP2203418B1/en active Active
- 2008-09-19 KR KR1020080092366A patent/KR101226669B1/ko active IP Right Grant
- 2008-09-19 US US12/733,711 patent/US8076377B2/en not_active Expired - Fee Related
- 2008-09-19 CN CN2008801080472A patent/CN101855204B/zh active Active
- 2008-09-19 WO PCT/KR2008/005574 patent/WO2009038396A2/en active Application Filing
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2010
- 2010-10-19 KR KR1020100101884A patent/KR20100126237A/ko not_active Application Discontinuation
- 2010-10-19 KR KR1020100101886A patent/KR20100126238A/ko not_active Application Discontinuation
- 2010-10-19 KR KR1020100101885A patent/KR20100126635A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
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CN101855204A (zh) | 2010-10-06 |
KR20100126635A (ko) | 2010-12-02 |
EP2203418A4 (en) | 2014-05-21 |
KR20100126237A (ko) | 2010-12-01 |
WO2009038396A3 (en) | 2009-05-14 |
JP2010539229A (ja) | 2010-12-16 |
US8076377B2 (en) | 2011-12-13 |
KR101226669B1 (ko) | 2013-01-25 |
CN101855204B (zh) | 2013-09-11 |
KR20100126238A (ko) | 2010-12-01 |
WO2009038396A2 (en) | 2009-03-26 |
US20100249241A1 (en) | 2010-09-30 |
JP5292404B2 (ja) | 2013-09-18 |
EP2203418B1 (en) | 2017-10-25 |
EP2203418A2 (en) | 2010-07-07 |
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