KR20080102752A - 이소람네틴을 유효성분으로 포함하는 피부 미백 개선제 - Google Patents
이소람네틴을 유효성분으로 포함하는 피부 미백 개선제 Download PDFInfo
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- KR20080102752A KR20080102752A KR1020070049592A KR20070049592A KR20080102752A KR 20080102752 A KR20080102752 A KR 20080102752A KR 1020070049592 A KR1020070049592 A KR 1020070049592A KR 20070049592 A KR20070049592 A KR 20070049592A KR 20080102752 A KR20080102752 A KR 20080102752A
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- South Korea
- Prior art keywords
- composition
- skin
- isoramnetine
- isorhamnetin
- active ingredient
- Prior art date
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Cosmetics (AREA)
Abstract
Description
시험항목 | 이소람네틴 (1 ppm) | 이소람네틴 (10 ppm) | 이소람네틴 (50 ppm) |
콜라겐 합성증가율 | 11 | 23 | 32 |
콜라게네이즈 억제율 | 3 | 25 | 40 |
시험항목 | 제조예 A (이소람네틴 0.01% 함유크림) | 제조예 A (이소람네틴 0.05% 함유크림) | 제조예 A (이소람네틴 1% 함유크림) | 비교 제조예 (이소람네틴 0% 함유크림) |
피부탄력도 | 2.93 | 3.11 | 3.37 | 2.71 |
성분 | 함량 (중량%) |
이소람네틴 | 0.01, 0.05 또는 1.00 |
호호바 오일 | 5.0 |
유동 파라핀 | 7.0 |
세틸아릴 알코올 | 2.0 |
폴리글리세릴-3 메칠 글루코스 디스테아레이 | 2.0 |
글리세릴 스테아레이트 | 0.5 |
스쿠알란 | 3.0 |
프로필렌글리콜 | 4.0 |
글리세린 | 5.0 |
트리에탄올 아민 | 0.3 |
카르복시 비닐폴리머 | 0.3 |
토코페릴 아세테이트 | 0.2 |
방부제, 향 | 미량 |
정제수 | 잔량 |
합계 | 100 |
시료 | 처리농도 (ppm) | 멜라닌 생성 억제율 (%) |
알부틴 | 50 | 21 |
이소람네틴 | 1 | 0 |
10 | 15 | |
50 | 24 |
시료 | 처리 농도 (ppm) | 세포내 타이로시네이즈 활성 억제율 (%) |
알부틴 | 100 | 24 |
이소람네틴 | 1 | 2 |
10 | 20 | |
50 | 27 |
시료 | 처리 농도 (%) | 미백효과 (△L) |
이소람네틴 | 0.01 | 0.31 |
0.1 | 0.37 | |
알부틴 | 1.0 | 0.35 |
대조군 | - | 0.27 |
시험 물질 | 반응이 나타난 피검자 수 | 평균 반응도 | ||||||||
1주 | 2주 | 3주 | ||||||||
1차 | 2차 | 3차 | 4차 | 5차 | 6차 | 7차 | 8차 | 9차 | ||
± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ||
대조군(스쿠알렌) | 1 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.09 |
이소람네틴 (1%) [시험군 1] | 0 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.00 |
이소람네틴 (5%) [시험군 2] | 1 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.09 |
이소람네틴 (10%) [시험군 3] | 2 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.18 |
시료 | COX 활성(%) |
LPS (1 ㎍/ml) | 100 |
LPS(1 ㎍/ml)+ 이소람네틴(1 ppm) | 87 |
LPS(1 ㎍/ml)+ 이소람네틴(10 ppm) | 76 |
LPS(1 ㎍/ml)+ 이소람네틴(50 ppm) | 64 |
시료 | 처리 농도 (ppm) | 자유라디칼 소거율 (%) |
이소람네틴 | 10 | 35 |
50 | 62 | |
100 | 90 |
시료 | 일수 | 체중 (g) | ||
무처리군 | 이소람네틴 (0.1%) | 이소람네틴 (1%) | ||
이소람네틴 리포좀제형 | 5 | 27 | 27 | 28 |
10 | 34 | 33 | 33 | |
15 | 40 | 37 | 37 |
성분 | 함량(%) | |
시험군 1 | 시험군 2 | |
이소람네틴 | 0.1 | 1.0 |
방부제(그람벤) | 0.8 | 0.1 |
점증제(Xanthan-Gum) | 0.3 | 0.1 |
총 중량 | 100 | 100 |
- | 대조군 | 비교군 | 실험군 1 | 실험군 2 |
효능/효과 | 1 | 4 | 3 | 4 |
Claims (10)
- 이소람네틴(Isorhamnetin)을 유효성분으로 포함하는 피부 상태(skin conditions) 개선용 조성물.
- 이소람네틴(Isorhamnetin)을 유효성분으로 포함하는 염증억제용 조성물.
- 이소람네틴(Isorhamnetin)을 유효성분으로 포함하는 항산화용 조성물.
- 이소람네틴(Isorhamnetin)을 유효성분으로 포함하는 항비만용 조성물.
- 제 1 항에 있어서, 상기 피부 상태의 개선은 주름 개선, 피부 미백 개선, 발모 촉진 또는 탈모 방지인 것을 특징으로 하는 조성물.
- 제 1 항 내지 제 5 항 중 어느 한 항에 있어서, 상기 이소람네틴은 조성물의 총 중량을 기준으로 0.0001-10.0 중량%로 포함되는 것을 특징으로 하는 조성물.
- 제 1 항 내지 제 5 항 중 어느 한 항에 있어서, 상기 조성물은 화장료 조성물인 것을 특징으로 하는 조성물.
- 제 7 항에 있어서, 상기 조성물은 용액, 현탁액, 유탁액, 페이스트, 겔, 크림, 로션, 파우더, 비누, 계면활성제-함유 클린싱, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션 및 스프레이로 구성된 군으로부터 선택되는 제형을 갖는 것을 특징으로 하는 조성물.
- 제 1 항 내지 제 5 항 중 어느 한 항에 있어서, 상기 조성물은 약제학적 조성물인 것을 특징으로 하는 조성물.
- 제 1 항 내지 제 5 항 중 어느 한 항에 있어서, 상기 조성물은 식품 조성물인 것을 특징으로 하는 조성물.
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KR1020070049592A KR100902769B1 (ko) | 2007-05-22 | 2007-05-22 | 이소람네틴을 유효성분으로 포함하는 피부 미백 개선제 |
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Cited By (2)
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CN112190496A (zh) * | 2020-08-11 | 2021-01-08 | 上海中医药大学附属龙华医院 | 富含异鼠李素的产品、制备方法以及异鼠李素的提取方法 |
CN117924504A (zh) * | 2024-01-26 | 2024-04-26 | 武汉戴安生物技术有限公司 | 一种制备高亲和力psma纳米抗体的方法 |
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JPH06183940A (ja) * | 1992-12-21 | 1994-07-05 | Lion Corp | 口腔用組成物 |
KR20020080655A (ko) * | 2001-04-17 | 2002-10-26 | 주식회사 참 존 | 편축 추출물을 함유하는 미백제 |
KR20070018145A (ko) * | 2004-07-23 | 2007-02-13 | 더 프록터 앤드 갬블 캄파니 | 플라보노이드 및 비타민 b3를 함유하는 피부 케어 조성물 |
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CN112190496A (zh) * | 2020-08-11 | 2021-01-08 | 上海中医药大学附属龙华医院 | 富含异鼠李素的产品、制备方法以及异鼠李素的提取方法 |
CN117924504A (zh) * | 2024-01-26 | 2024-04-26 | 武汉戴安生物技术有限公司 | 一种制备高亲和力psma纳米抗体的方法 |
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