KR20080099279A - 이관능성 레조르시놀, 티오레조르시놀, 및 디티오레조르시놀 유도체 금속 킬레이팅 컨쥬게이트 - Google Patents

이관능성 레조르시놀, 티오레조르시놀, 및 디티오레조르시놀 유도체 금속 킬레이팅 컨쥬게이트 Download PDF

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Publication number
KR20080099279A
KR20080099279A KR1020087020548A KR20087020548A KR20080099279A KR 20080099279 A KR20080099279 A KR 20080099279A KR 1020087020548 A KR1020087020548 A KR 1020087020548A KR 20087020548 A KR20087020548 A KR 20087020548A KR 20080099279 A KR20080099279 A KR 20080099279A
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KR
South Korea
Prior art keywords
payito
alcohol
phosphonic
sulfatoethylsulfonyl
alkyl
Prior art date
Application number
KR1020087020548A
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English (en)
Korean (ko)
Inventor
데니스. 에이. 무어
Original Assignee
말린크로트, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 말린크로트, 인코포레이티드 filed Critical 말린크로트, 인코포레이티드
Publication of KR20080099279A publication Critical patent/KR20080099279A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
KR1020087020548A 2006-02-24 2007-02-20 이관능성 레조르시놀, 티오레조르시놀, 및 디티오레조르시놀 유도체 금속 킬레이팅 컨쥬게이트 KR20080099279A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77678506P 2006-02-24 2006-02-24
US60/776,785 2006-02-24
US78436306P 2006-03-21 2006-03-21
US60/784,363 2006-03-21

Publications (1)

Publication Number Publication Date
KR20080099279A true KR20080099279A (ko) 2008-11-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087020548A KR20080099279A (ko) 2006-02-24 2007-02-20 이관능성 레조르시놀, 티오레조르시놀, 및 디티오레조르시놀 유도체 금속 킬레이팅 컨쥬게이트

Country Status (7)

Country Link
US (1) US8119103B2 (US20090082324A1-20090326-C00003.png)
EP (1) EP1988925A2 (US20090082324A1-20090326-C00003.png)
JP (1) JP2009527559A (US20090082324A1-20090326-C00003.png)
KR (1) KR20080099279A (US20090082324A1-20090326-C00003.png)
CA (1) CA2643145C (US20090082324A1-20090326-C00003.png)
IL (1) IL193518A0 (US20090082324A1-20090326-C00003.png)
WO (1) WO2007100563A2 (US20090082324A1-20090326-C00003.png)

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US20090053137A1 (en) * 2006-03-15 2009-02-26 Moore Dennis A Chelating Conjugates Having a Substituted Aromatic Moiety and Derivatives Thereof
US20100055043A1 (en) * 2006-10-30 2010-03-04 Moore Dennis A Poly-Halo Metal X-ray Contrast Agents
US9005577B2 (en) * 2008-04-30 2015-04-14 Siemens Medical Solutions Usa, Inc. Substrate based PET imaging agents
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
EP3544964B1 (en) 2016-11-28 2020-06-17 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
SI3568205T1 (sl) 2017-01-12 2023-12-29 Radiomedix Inc. Zdravljenje rakastih celic, ki prekomerno izražajo receptorje za somatostatin, z uporabo derivatov okreotida, kelatiranih v radioizotope
AU2019382881A1 (en) 2018-11-23 2021-05-20 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof

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FI48507C (fi) 1972-06-29 1974-10-10 Orion Yhtymae Oy Menetelmä metallispesifisten atsoväriaineiden kiinnittämiseksi silloit tajaryhmän avulla kiinteään kantaja-ainekseen, erikoisesti selluloosak uituun.
JPS6048916A (ja) 1983-08-29 1985-03-16 Risuburan Prod:Kk 白髪を黒くする整髪用乳化物の製造方法
MX174467B (es) * 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos
CN1016693B (zh) * 1987-06-05 1992-05-20 北京工业大学 新顺铂铬合物的制备方法
EP0420942A1 (en) * 1988-06-24 1991-04-10 The Dow Chemical Company Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
US5559149A (en) * 1990-01-29 1996-09-24 Johnson & Johnson Consumer Products, Inc. Skin care compositions containing retinoids
US5186923A (en) * 1990-10-10 1993-02-16 Brigham And Womens Hospital Enhancement of cellular accumulation of lipophilic cationic organometallic compounds by reduction of intramembrane potential
US5147632A (en) * 1990-10-31 1992-09-15 Warner-Lambert Company Anti-plaque compositions comprising a combination of morpholinoamino alcohol and chelating agent
US5310539A (en) * 1991-04-15 1994-05-10 Board Of Regents, The University Of Texas System Melanin-based agents for image enhancement
MX9305039A (es) * 1992-08-19 1994-05-31 Mallinckrodt Medical Inc Ligandos para ga-68 para aplicaciones cardiacas de tep.
JPH1053515A (ja) 1996-08-09 1998-02-24 Ajinomoto Co Inc 皮膚外用剤
JPH10130155A (ja) 1996-10-28 1998-05-19 Chiyuuyakuken:Kk 病変組織治療用組成物、その製法およびその用途
EP0976392A1 (en) 1998-07-29 2000-02-02 Unilever Plc Liquid compositions comprising antioxidants and ED3A-derived chelating surfactants as stabilizers
US6685914B1 (en) * 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
PE20011099A1 (es) 2000-02-14 2001-11-23 Procter & Gamble Composiciones para el suministro topico de un agente farmaceuticamente activo que tiene oxidacion reducida
US20030161862A1 (en) * 2000-03-28 2003-08-28 Susumu Hizukuri Bacterial growth regulators or inhibitors with the use of 1,5-d-anhydrofructose
US6602989B1 (en) * 2000-05-17 2003-08-05 The Research Foundation Of State University Of New York Synthesis, characterization, and application of pyridylazo bioconjugates as diagnostic and therapeutic agents
US6710192B2 (en) * 2001-10-16 2004-03-23 Arco Chemical Technology, L.P. Dense phase epoxidation
WO2003045449A1 (fr) * 2001-11-26 2003-06-05 Yugen Kaisha Okada Giken Agent desodorisant et preparation de shampooing cosmetique le contenant
US7176239B2 (en) * 2003-07-11 2007-02-13 Suming Wang Methods and compositions for treatment of Ataxia-telangeictasia
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Also Published As

Publication number Publication date
US8119103B2 (en) 2012-02-21
IL193518A0 (en) 2011-08-01
JP2009527559A (ja) 2009-07-30
WO2007100563A2 (en) 2007-09-07
US20090082324A1 (en) 2009-03-26
EP1988925A2 (en) 2008-11-12
WO2007100563A3 (en) 2008-03-20
CA2643145A1 (en) 2007-09-07
CA2643145C (en) 2014-04-29

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