KR20080094847A - 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법 - Google Patents

4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법 Download PDF

Info

Publication number
KR20080094847A
KR20080094847A KR1020087023971A KR20087023971A KR20080094847A KR 20080094847 A KR20080094847 A KR 20080094847A KR 1020087023971 A KR1020087023971 A KR 1020087023971A KR 20087023971 A KR20087023971 A KR 20087023971A KR 20080094847 A KR20080094847 A KR 20080094847A
Authority
KR
South Korea
Prior art keywords
formula
azd0530
compound
chloro
conveniently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020087023971A
Other languages
English (en)
Korean (ko)
Inventor
제임스 가이어 포드
제임스 프란시스 맥케이브
앤 오키어니-맥뮬란
필립 오키페
시몬 마크 포인톤
린 포웰
마크 퍼디
제인 위드날
Original Assignee
아스트라제네카 아베
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아스트라제네카 아베 filed Critical 아스트라제네카 아베
Publication of KR20080094847A publication Critical patent/KR20080094847A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020087023971A 2004-12-17 2005-12-14 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법 Withdrawn KR20080094847A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0427697.8 2004-12-17
GBGB0427697.8A GB0427697D0 (en) 2004-12-17 2004-12-17 Chemical process

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020077015972A Division KR20070090004A (ko) 2004-12-17 2005-12-14 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법

Publications (1)

Publication Number Publication Date
KR20080094847A true KR20080094847A (ko) 2008-10-24

Family

ID=34090249

Family Applications (6)

Application Number Title Priority Date Filing Date
KR1020087023971A Withdrawn KR20080094847A (ko) 2004-12-17 2005-12-14 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법
KR1020087023973A Withdrawn KR20080094849A (ko) 2004-12-17 2005-12-14 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법
KR1020077015972A Ceased KR20070090004A (ko) 2004-12-17 2005-12-14 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법
KR1020117022793A Ceased KR20110114727A (ko) 2004-12-17 2005-12-14 4-（6-클로로-2,3-메틸렌다이옥시아닐리노）-7-［2-（4-메틸피페라진-1-일）에톡시］-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법
KR1020087023969A Withdrawn KR20080094846A (ko) 2004-12-17 2005-12-14 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법
KR1020087023972A Withdrawn KR20080094848A (ko) 2004-12-17 2005-12-14 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법

Family Applications After (5)

Application Number Title Priority Date Filing Date
KR1020087023973A Withdrawn KR20080094849A (ko) 2004-12-17 2005-12-14 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법
KR1020077015972A Ceased KR20070090004A (ko) 2004-12-17 2005-12-14 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법
KR1020117022793A Ceased KR20110114727A (ko) 2004-12-17 2005-12-14 4-（6-클로로-2,3-메틸렌다이옥시아닐리노）-7-［2-（4-메틸피페라진-1-일）에톡시］-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법
KR1020087023969A Withdrawn KR20080094846A (ko) 2004-12-17 2005-12-14 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법
KR1020087023972A Withdrawn KR20080094848A (ko) 2004-12-17 2005-12-14 4-(6-클로로-2,3-메틸렌다이옥시아닐리노)-7-[2-(4-메틸피페라진-1-일)에톡시]-5-테트라하이드로피란-4-일옥시퀴나졸린, 이의 중간체 및 이의 결정질 염의 제조 방법

Country Status (16)

Country Link
US (1) US8304417B2 (https=)
EP (1) EP1871769B1 (https=)
JP (2) JP5161584B2 (https=)
KR (6) KR20080094847A (https=)
CN (1) CN101115744B (https=)
AU (2) AU2005315458B2 (https=)
BR (1) BRPI0519085A2 (https=)
CA (2) CA2590735C (https=)
ES (1) ES2622480T3 (https=)
GB (1) GB0427697D0 (https=)
IL (1) IL183525A0 (https=)
MX (1) MX2007007210A (https=)
NO (1) NO20072755L (https=)
NZ (1) NZ555468A (https=)
WO (1) WO2006064217A2 (https=)
ZA (1) ZA200704532B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0412074D0 (en) * 2004-05-29 2004-06-30 Astrazeneca Ab Combination product
WO2009068906A2 (en) * 2007-11-26 2009-06-04 Astrazeneca Ab Combinations comprising zd4054 and a src family kinase inhibitor 172
CN103275072B (zh) * 2013-05-22 2016-01-20 苏州明锐医药科技有限公司 塞卡替尼的制备方法
US11241434B2 (en) 2013-06-13 2022-02-08 Yale Uninversity Compositions and methods for improving cognition in a subject
US10660957B2 (en) * 2013-06-13 2020-05-26 Yale University Compositions and methods for treating an Aβ-modulated disease or disorder or improving cognition in a subject
US10369152B2 (en) 2015-02-13 2019-08-06 The Brigham And Women's Hospital, Inc. Methods and compositions for the treatment or prevention of abnormal bone formation in a soft tissue
PT3930715T (pt) 2019-02-27 2024-08-02 Astrazeneca Ab Saracatinib para uso no tratamento de fibrose pulmonar idiopática
CN116332789A (zh) * 2023-03-10 2023-06-27 上海康鹏科技股份有限公司 一种4-氨基-2-氟苯甲酰胺的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73993C2 (uk) * 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
CA2419301C (en) 2000-08-21 2009-12-08 Astrazeneca Ab Quinazoline derivatives
DE60229046D1 (de) 2001-04-19 2008-11-06 Astrazeneca Ab Chinazolin derivate
RU2350618C2 (ru) 2002-11-04 2009-03-27 Астразенека Аб ПРОИЗВОДНЫЕ ХИНАЗОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Src ТИРОЗИНКИНАЗЫ
GB0226434D0 (en) 2002-11-13 2002-12-18 Astrazeneca Ab Combination product
GB0307333D0 (en) 2003-03-29 2003-05-07 Astrazeneca Ab Therapeutic agent
GB0309850D0 (en) 2003-04-30 2003-06-04 Astrazeneca Ab Quinazoline derivatives
GB0310401D0 (en) * 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent

Also Published As

Publication number Publication date
ZA200704532B (en) 2008-07-30
CN101115744A (zh) 2008-01-30
US8304417B2 (en) 2012-11-06
EP1871769A2 (en) 2008-01-02
KR20080094846A (ko) 2008-10-24
KR20110114727A (ko) 2011-10-19
US20090099196A1 (en) 2009-04-16
CA2675642A1 (en) 2006-06-22
EP1871769B1 (en) 2017-02-22
JP5161584B2 (ja) 2013-03-13
KR20080094849A (ko) 2008-10-24
AU2005315458B2 (en) 2009-03-12
AU2005315458A1 (en) 2006-06-22
CA2590735C (en) 2009-11-10
BRPI0519085A2 (pt) 2008-12-23
NZ555468A (en) 2010-12-24
WO2006064217A3 (en) 2006-12-21
WO2006064217A2 (en) 2006-06-22
WO2006064217A8 (en) 2007-07-05
MX2007007210A (es) 2007-11-07
IL183525A0 (en) 2007-09-20
AU2009200622A1 (en) 2009-03-12
KR20070090004A (ko) 2007-09-04
JP2008524183A (ja) 2008-07-10
CA2590735A1 (en) 2006-06-22
CN101115744B (zh) 2012-02-01
JP2009143920A (ja) 2009-07-02
NO20072755L (no) 2007-07-02
ES2622480T3 (es) 2017-07-06
KR20080094848A (ko) 2008-10-24
GB0427697D0 (en) 2005-01-19

Similar Documents

Publication Publication Date Title
EP1480650B1 (en) Novel crystalline forms of the anti-cancer compound zd1839
AU727013B2 (en) Heterocyclic compound and antitumor agent comprising the same as effective component
US10561646B2 (en) EGFR inhibitor and pharmaceutically acceptable salt and polymorph thereof, and use thereof
JP2009143920A (ja) 化学的方法
CN109071530B (zh) 稠合嘧啶哌啶环衍生物及其制备方法和应用
RU2369607C1 (ru) Соли и полиморфные модификации ингибитора vegf-r
HK40088129A (en) Crystalline form of compound
HK1070582B (en) Novel crystalline forms of the anti-cancer compound zd1839

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20080930

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid