KR20080017679A - Cosmetic composition for abirritating skin containing extract of rheum undulatum as active ingredient - Google Patents

Abstract

A cosmetic composition comprising the extract of Rheum undulatum is provided to reduce stimulation of cosmetic raw materials to the skin, preserve useful effects of functional raw materials, and reduce side effects of cosmetics, so that the composition is useful as a cosmetic adjuvant having skin irritation-alleviating effects. A cosmetic composition for alleviating skin irritation caused by cosmetic raw materials comprises 0.001-5.0 wt.% of the extract of Rheum undulatum, and is formulated as solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray, wherein the cosmetic raw materials causing skin irritation include lactic acid, glycolic acid, salicylic acid and retinoic acid; and the Rheum undulatum extract is prepared by extracting leaf, flower, root, stem or bark of Rheum undulatum with a solvent selected from water, C1-4 anhydrous or hydrous lower alcohol, acetone, ethyl acetate, chloroform, 1,3-butylene glycol and butyl acetate.

Description

Cosmetic composition for relieving skin irritation containing rhubarb extract as an active ingredient {Cosmetic Composition for Abirritating Skin Containing Extract of Rheum undulatum as Active Ingredient}

The present invention relates to a cosmetic composition for skin irritation relief.

Recently, the number of consumers who feel sensitive skin is increasing. In the survey of general consumers, 30-40% of respondents said they were sensitive skin, and this rate is increasing. The increasing rate of sensitive skin is due to the increase in ultraviolet radiation due to the destruction of the ozone layer, the drying of the living space, the constitution of allergies, stress, and the increase of chemical harmful substances. On the other hand, the recent shift toward consumer-friendly and hypoallergenic consumerism has also been suggested to be a factor in improving awareness of sensitive skin. Accordingly, interest in substances that alleviate skin irritation caused by cosmetics is increasing. It is rising.

Generally, various raw materials are used to make cosmetics, and typically 20 to 50 kinds of raw materials are used. These ingredients have been proved to be safe through skin irritation tests, but when applied to the product they can cause irritation such as inflammation, itching and allergies on the skin. However, these stimulus reactions do not happen to everyone, and may only happen to certain people.

Skin irritation that may occur with the use of cosmetics includes irritation such as itching, stinging and burning, and erythema and edema. Contact dermatitis includes irritant contact dermatitis, allergic contact dermatitis, sensory irritation, and phototoxic dermatitis, but it is difficult to clearly distinguish them, and most of them are mixed with each other.

First of all, in order for skin irritation to occur, skin penetration by cosmetics must first occur, and they interact with the epidermis or dermal cells to activate the immune system and cause irritation. In order to alleviate such skin irritation, various methods, such as a method of removing skin irritants, have been mobilized, but functional cosmetics have recently been increasing. Therefore, cosmetics manufacturers are making efforts to minimize the irritation of the cosmetic raw material by applying a commonly used irritant substance to the product. However, this study is limited because the functional raw material itself often acts as a stimulus source. Therefore, it is necessary to select a substance that can reduce side effects caused by cosmetics and alleviate skin irritation while maintaining the effects of the functional raw materials.

The present inventors conducted a thorough study on natural products to compensate for the above drawbacks, and found that rhubarb extract is a substance having an effect of stabilizing the formulation, reducing side effects caused by cosmetics, and alleviating skin irritation. Completed.

Accordingly, it is an object of the present invention to provide a cosmetic composition for skin irritation relief comprising rhubarb extract as an active ingredient.

Other objects and advantages of the present invention will become apparent from the following examples and claims.

According to another aspect of the present invention, the present invention provides a cosmetic composition for alleviating skin irritation comprising rhubarb extract as an active ingredient.

The present inventors prepared extracts by various extraction methods using a plurality of natural products as a raw material, and as a result of performing the task of selecting a substance excellent in stimulating cell stimulation and inhibiting inflammation from a stimulus source, rhubarb extract of the present invention described above. I found the best fit for my purpose.

Rheum undulatum used as an active ingredient of the present invention is a perennial herb of a dicotyledonous cultivation group, phyllopsis dulcifolia, which grows in a wetland of a valley, and removes the bark and fine roots of the root of 6-7 years old. Use it as a medicine. It is used as an anti-inflammatory laxative in Korean medicine and is good for constipation and indigestion when taken. It is also used as a folk medicine for burns.

In the present invention, rhubarb extract refers to an extract obtained from various organs or parts (for example, leaves, flowers, roots, stems and shells, etc.) of rhubarb, preferably an extract obtained from the root of rhubarb.

Rhubarb extracts of the present invention may be prepared according to conventional methods known in the art, i.e., under conventional conditions of temperature and pressure, using conventional solvents.

The rhubarb extract can be derived from a variety of extraction solvents, such as water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms (methanol, ethanol, propanol and butanol), acetone, ethyl acetate, chloroform, 1,3-butylene glycol and butyl It can be obtained from rhubarb as an extraction solvent selected from the group consisting of acetate. More preferably, the rhubarb extract of the present invention is obtained using water. On the other hand, it will be apparent to those skilled in the art that the extract of the present invention can obtain an extract having substantially the same effect using not only the aforementioned extraction solvent but also other extraction solvents.

In addition, the extract of the present invention includes not only the extract by the above-mentioned extraction solvent, but also the extract that has undergone a conventional purification process. Obtained by various additional purification methods, such as, for example, separation using an ultrafiltration membrane having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity). The active fraction is also included in the extract of the present invention.

According to a preferred embodiment of the present invention, the content of the extract is 0.001-5.0% by weight relative to the total weight of the cosmetic composition. If the content is less than the expected effect is difficult to appear, if the content is exceeded the effect is no longer increased.

Rhubarb extract of the present invention to alleviate the skin irritation caused by external substances and has anti-inflammatory activity, and to reduce the skin irritation caused by cosmetic raw materials. Therefore, rhubarb extract of the present invention can be used as a cosmetic adjuvant to relieve skin irritation by the cosmetic raw material.

Raw material causing skin irritation in the cosmetic composition includes a natural extract and ingredients that can be commonly used in cosmetics. Representative raw materials that cause skin irritation include, but are not limited to, lactic acid, glycolic acid, salicylic acid and retinoic acid.

The cosmetic composition of the present invention is prepared as a composition comprising rhubarb extract as an active ingredient, and may be applied before or after applying a cosmetic composition having a large skin irritation to the skin. In addition, rhubarb extract may be added to the skin composition by adding to the skin irritant composition.

The ingredients included in the cosmetic composition of the present invention include ingredients commonly used in cosmetic compositions in addition to the rhubarb extract as an active ingredient, and include, for example, conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings, And carriers.

Cosmetic compositions of the present invention may be prepared in any formulation conventionally prepared in the art and include, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing , Oils, powder foundations, emulsion foundations, wax foundations and sprays, and the like, but are not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, and especially in the case of spray, additionally chlorofluorohydrocarbon, Propellant such as propane / butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The cosmetic composition of the present invention improves skin safety of cosmetics by inhibiting skin irritation that may occur when cosmetics are applied to the skin by using rhubarb extract, inhibits inflammation developed by skin irritation, and stability of formulation. This is excellent.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those of ordinary skill in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident.

Preparation Example 1 Preparation of Rhubarb Extract

After washing with purified water and crushed 1kg of dried rhubarb into small pieces, 5 liters of purified water was added thereto, extracted by heating at 70-90 ° C. for 5 hours in an extractor equipped with a cooling condenser, and filtered with 300 mesh filter cloth. After aging at 7O < 0 > C for 10 < 0 > C, it was aged and filtered through Whatman 5 filter paper. The filtrate was dried at 70 ° C. using a rotary evaporator to obtain an extract having a dry weight of 63.4 g.

Experimental Example  One: rhubarb  Anti-inflammatory Effects of Extracts- Carrageenan  Foot Edema Experiment

Carrageenan foot edema experiment was performed to determine whether rhubarb extract of the present invention has an anti-inflammatory effect. Rhubarb extract obtained in Preparation Example 1 was administered to the rat intraperitoneally by 10-100 mg / kg. One hour after the administration of the extract, 0.5 ml of 0.1% carrageenan solution (Sigma, United States) was injected into the hind paws of the experimental animals to cause inflammation. Immediately after carrageenan injection and 4 hours after injection, the volume change of the rat's foot was measured. The edema inhibition rate was calculated according to Equation 1 using the measured foot volume change, and the results are shown in Table 1 below.

ΔV in the above equation is the volume change of the foot.

Anti-inflammatory effect Extract Dose (mg / kg) Edema inhibition rate (%) 10 26.6 20 33.4 50 47.9 100 64.1 200 76.5

As shown in the results of Table 1, rhubarb extract increased the edema inhibition rate dose-dependently.

Experimental Example 2: Anti-inflammatory effect test of rhubarb extract

In order to measure the anti-inflammatory effect of rhubarb extract, the anti-inflammatory effect was measured in 20 people with no skin disease or skin allergy symptoms. The age distribution was 20-39 years old and the average age was 31 years old. The test method was as follows. After measuring three measurement locations on the upper arm, the erythema (a * value) of the skin was measured with a chromameter. 5% rhubarb extract (experimental group) and licoriceic acid (comparative group, conventional anti-inflammatory agent) were applied four times at 1 hour intervals, and the other one (control) was not applied at two measurement sites. After 20-30 minutes of last application, the measurement site was lightly wiped with running water. When the water was dried on the upper arm, 3 mM methyl nicotimate (0.04%) was soaked in 80 μl of paper disk, and placed for 1 minute and 30 seconds. After 1 minute and 30 seconds, the paper disk was removed and washed with running water. After 20-30 minutes of inflammation, erythema develops. The incidence of erythema is measured by chromatometer and the degree of erythema suppression is evaluated by comparing with erythema at the beginning of the experiment. Evaluation of the anti-inflammatory effect was performed as shown in Equation 2 below, and the results are shown in Table 2.

Anti-inflammatory effect division Δa * (after treatment-before treatment) Erythema production rate (%) Anti-inflammatory effect (%) Control 1.42 100 - 5% licorice 1.01 71.1 28.9 5% Rhubarb Extract 0.49 34.5 65.5

Through the experimental results of Table 2, it can be seen that the anti-inflammatory effect of the rhubarb extract of the present invention is far superior to the conventional anti-inflammatory licorice.

On the basis of the experimental example, it proposes a cosmetic composition of various solubilizing agent type and emulsifier type containing rhubarb extract excellent in skin irritation relief effect. Although this is described in detail in the following formulation example, the composition of the present invention is not limited only to the following examples.

Formulation Example 1: Softener (Skin Lotion)

A softening lotion containing rhubarb extract was prepared according to a conventional method as shown in Table 3 below.

ingredient Content (% by weight) Rhubarb extract 2.0 glycerin 5.0 1,3-butylene glycol 3.0 PEG 1500 1.0 Allantoin 0.1 DL-panthenol 0.3 EDTA-2Na 0.02 Benzophenone-9 0.04 Sodium hyaluronate 5.0 ethanol 10.0 Octicdodeceth-16 0.2 Polysorbate 20 0.2 incense 0.02 Uniside-U 13 0.01 Green # 13 0.001 Distilled water Remaining amount Sum 100

Formulation Example 2. Converging Cosmetic Water

Converging cosmetic water containing rhubarb extract as shown in Table 4 below was prepared according to a conventional method.

ingredient Content (% by weight) Rhubarb extract 2.0 glycerin 2.0 1,3-butylene glycol 2.0 Allantoin 0.2 DL-panthenol 0.2 EDTA-2Na 0.02 Benzophenone-9 0.04 Sodium hyaluronate 3.0 ethanol 15.0 Polysorbate 20 0.3 Witch Hagel Extract 2.0 Citric acid a very small amount incense 0.02 Uniside-U 13 0.01 Green # 13 0.001 Distilled water Remaining amount Sum 100

Formulation Example 3. Nutrients

Nutrients containing rhubarb extract as shown in Table 5 below were prepared according to a conventional method.

ingredient Content (% by weight) Rhubarb extract 2.0 Glyceryl Stearate SE 1.5 Cetearyl Alcohol 1.5 lanolin 1.5 Polysorbate 60 1.3 Sorbitan stearate 0.5 Cured Vegetable Oil 1.0 Mineral oil 5.0 Squalane 3.0 Trioctanoine 2.0 Dimethicone 0.8 Tocopherol Acetate 0.5 Carboxyvinyl Polymer 0.12 glycerin 5.0 1,3-butylene glycol 3.0 Sodium hyaluronate 5.0 Triethanolamine 0.12 incense 0.01 Uniside-U 13 0.02 Green # 3 0.003 Distilled water Remaining amount Sum 100

Formulation Example 4. Nutrition Cream

Nutritious cream containing rhubarb extract was prepared according to a conventional method as shown in Table 6 below.

ingredient Content (% by weight) Rhubarb extract 5.0 Lipophilic monostearate 2.0 Cetearyl Alcohol 2.2 Stearic acid 1.5 Beeswax 1.0 Polysorbate 60 1.5 Sorbitan stearate 0.6 Cured Vegetable Oil 1.0 Squalane 3.0 Mineral oil 5.0 Trioctanoine 5.0 Dimethicone 1.0 Sodium magnesium silicate 0.1 glycerin 5.0 Betaine 3.0 Triethanolamine 1.0 Sodium hyaluronate 4.0 incense 0.01 Uniside-Y13 0.02 Green # 3 0.003 Distilled water Remaining amount Sum 100

Formulation Example 5. Massage Cream

A massage cream containing rhubarb extract was prepared according to a conventional method as shown in Table 7 below.

ingredient Content (% by weight) Rhubarb extract 4.0 Lipophilic Monostearic Acid Glycerin 1.5 Cetearyl Alcohol 1.5 Stearic acid 1.0 Polysorbate 60 1.5 Sorbitan stearate 0.6 Isostearyl Isosterate 5.0 Squalane 5.0 Mineral oil 35.0 Dimethicone 0.5 Hydroxyethyl cellulose 0.12 glycerin 6.0 Triethanolamine 0.7 incense 0.01 Uniside-Y13 0.02 Green # 3 0.003 Distilled water Remaining amount Sum 100

Formulation Example 6. Essence

An essence containing rhubarb extract was prepared according to a conventional method as shown in Table 8 below.

ingredient Content (% by weight) Rhubarb extract 4.0 glycerin 10.0 Betaine 5.0 PEG 1500 2.0 Allantoin 0.1 DL-panthenol 0.3 EDTA-2Na 0.02 Benzophenone-9 0.04 Hydroxyethyl cellulose 0.1 Sodium hyaluronate 8.0 Carboxy Vinyl Polymer 0.2 Triethanolamine 0.18 Octyldodecanol 0.3 Octyldodeceth-16 0.4 ethanol 6.0 incense 0.02 Uniside-U 13 0.01 Green # 3 0.001 Distilled water Remaining amount Sum 100

Formulation Example 7 Pack

A pack containing rhubarb extract was prepared according to a conventional method as shown in Table 9 below.

ingredient Content (% by weight) Rhubarb extract 2.0 Polyvinyl alcohol 15.0 Cellulose gum 0.15 glycerin 3.0 PEG 1500 2.0 Chicdestrin 0.15 DL-panthenol 0.4 Allantoin 0.1 Glycyrisin Monoammonium 0.3 Nicotinamide 0.5 ethanol 6.0 PEG 40 Cured Castor Oil 0.3 incense a very small amount Uniside-Y13 0.02 Green # 3 0.003 Distilled water Remaining amount Sum 100

Experimental Example 3: Skin irritation relief effect in human application

In the past, skin irritation has not been shown to be hypersensitive, and currently, 20 females in their 20s and 30s with no skin disease or skin allergy symptoms have a skin irritant in the cosmetic formulation of Formulation Example 4 containing 5.0% by weight of rhubarb extract. 0.1% by weight of retinoic acid was added as an irritant (Example), and the irritation relieving effect was confirmed through a human skin patch test. At this time, the group replaced with purified water without adding retinoic acid and rhubarb extract was used as a control group, and the rhubarb extract contained in the cosmetic formulation of Formulation Example 4 was replaced with purified water and 0.1 wt% of retinoic acid was added as a comparative example.

Each morning and evening were used, and then questionnaires were marked for skin irritation and intensity. The results of the experiment were evaluated once a day, and divided into subjective stimuli and objective stimuli. The results are shown in Table 10.

Human application test result Test substance 24 hours 48 hours Average skin reactivity (n = 20) ± + ++ ± + ++ Control 2 - - --- 0.41 Comparative Example 1 13 3- 3 2- 5.41 Comparative Example 2 9 2- 3 1- 3.75 Example 4 2- One - - 1.87

As can be seen from the results of Table 10, the example containing 5.0% by weight of rhubarb extract alleviated to a high level both subjective and objective stimulation of skin irritation induced by retinoic acid.

Experimental Example 4: Stability test of the formulation of the cream containing rhubarb extract

The stability according to the temperature change of the cosmetic formulation of the present invention was tested. Nourishing cream of Formulation Example 4 containing rhubarb extract (Example 1), Cream added 0.1 wt% retinoic acid to cream of Formulation Example 4 containing rhubarb extract (Example 2), Rhubarb extract of Formulation Example 4 Was replaced with purified water (control), and the rhubarb extract of Formulation Example 4 replaced with purified water and the cream (Comparative Example) added 0.1% by weight of retinoic acid in an opaque glass container to maintain a constant temperature at 45 ℃ After storage for 1 week, and also put in an opaque glass container was kept constant at 4 ℃ and stored in a fully shaded refrigerator for 1 week, the degree of discoloration was measured. The results are shown in Table 11 below. At this time, the degree of product discoloration was evaluated by classifying into the following six grades.

※ criteria for evaluation of product discoloration

score Evaluation standard 0  No change One  Very little change 2  Little change 3  Slightly worse 4  Badly changed 5  Extremely severe

Safety test results of the formulation Temperature Discoloration degree of test substance Example 1 Example 2 Control Comparative example 45 ℃ 0 One 0 3 4 ℃ 0 0 0 2

As can be seen from the results of Table 11, in the comparative example in which the rhubarb extract was replaced with purified water, the discoloration did not occur, indicating that discoloration did not occur due to the other ingredients of the cream. It was found that the cream containing the formulation significantly improved the stability of the formulation compared to the cream containing only retinoic acid.

As described in detail above, the present invention provides a cosmetic composition for skin irritation relief comprising rhubarb extract as an active ingredient. Rhubarb extract of the present invention significantly alleviates the skin irritation caused by the cosmetic raw material compared to the existing anti-inflammatory agent, and also shows an increased anti-inflammatory activity, when used in cosmetics has an excellent skin irritation relief effect. Therefore, the cosmetic composition of the present invention can enhance skin safety of cosmetics because it can relieve skin irritation that may occur when cosmetics are applied to the skin using rhubarb extract.

Having described the specific part of the present invention in detail, it is apparent to those skilled in the art that the specific technology is merely a preferred embodiment, and the scope of the present invention is not limited thereto. Thus, the substantial scope of the present invention will be defined by the appended claims and equivalents thereof.

Claims (5)

Cosmetic composition for alleviating skin irritation containing Rheum undulatum extract as an active ingredient. The method of claim 1, wherein the rhubarb extract is water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol or butanol), acetone, ethyl acetate, chloroform, 1,3-butylene glycol and butyl acetate Cosmetic composition, characterized in that extracted using a solvent selected from the group consisting of. The cosmetic composition of claim 1, wherein the rhubarb extract exhibits skin irritation relief and anti-inflammatory effects. The cosmetic composition according to claim 1, wherein the rhubarb extract is contained in an amount of 0.001-5.0 wt% based on the total weight of the cosmetic. The composition of claim 1 wherein the cosmetic composition consists of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray Cosmetic composition, characterized in that it has a formulation selected from the group.