KR20070114820A - 돌연변이-ｃｆｔｒ 처리를 보정하는데 활성을 가지는화합물 및 이것의 사용 - Google Patents

돌연변이-ｃｆｔｒ 처리를 보정하는데 활성을 가지는화합물 및 이것의 사용 Download PDF

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Publication number
KR20070114820A
KR20070114820A KR1020077024001A KR20077024001A KR20070114820A KR 20070114820 A KR20070114820 A KR 20070114820A KR 1020077024001 A KR1020077024001 A KR 1020077024001A KR 20077024001 A KR20077024001 A KR 20077024001A KR 20070114820 A KR20070114820 A KR 20070114820A
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KR
South Korea
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group
cftr
pharmaceutical composition
pharmaceutically acceptable
compound
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KR1020077024001A
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English (en)
Korean (ko)
Inventor
알란 베르크만
니콜레타 페데몬드
루이스 제이. 브이. 갈리에타
Original Assignee
더 리젠츠 오브 더 유니버시티 오브 캘리포니아
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Application filed by 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 filed Critical 더 리젠츠 오브 더 유니버시티 오브 캘리포니아
Publication of KR20070114820A publication Critical patent/KR20070114820A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
KR1020077024001A 2005-03-18 2006-03-08 돌연변이-ｃｆｔｒ 처리를 보정하는데 활성을 가지는화합물 및 이것의 사용 KR20070114820A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66350105P 2005-03-18 2005-03-18
US60/663,501 2005-03-18

Publications (1)

Publication Number Publication Date
KR20070114820A true KR20070114820A (ko) 2007-12-04

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KR1020077024001A KR20070114820A (ko) 2005-03-18 2006-03-08 돌연변이-ｃｆｔｒ 처리를 보정하는데 활성을 가지는화합물 및 이것의 사용

Country Status (12)

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US (1) US8143295B2 (US20080318984A1-20081225-C00010.png)
EP (1) EP1863522A4 (US20080318984A1-20081225-C00010.png)
JP (1) JP2008538107A (US20080318984A1-20081225-C00010.png)
KR (1) KR20070114820A (US20080318984A1-20081225-C00010.png)
CN (1) CN101605543A (US20080318984A1-20081225-C00010.png)
AU (1) AU2006227833A1 (US20080318984A1-20081225-C00010.png)
BR (1) BRPI0608453A2 (US20080318984A1-20081225-C00010.png)
CA (1) CA2600869A1 (US20080318984A1-20081225-C00010.png)
IL (1) IL185999A0 (US20080318984A1-20081225-C00010.png)
MX (1) MX2007011512A (US20080318984A1-20081225-C00010.png)
RU (1) RU2007138584A (US20080318984A1-20081225-C00010.png)
WO (1) WO2006101740A2 (US20080318984A1-20081225-C00010.png)

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WO2006101740A2 (en) 2006-09-28
MX2007011512A (es) 2007-12-07
CA2600869A1 (en) 2006-09-28
US20080318984A1 (en) 2008-12-25
WO2006101740A3 (en) 2009-06-04
JP2008538107A (ja) 2008-10-09
CN101605543A (zh) 2009-12-16
AU2006227833A1 (en) 2006-09-28
RU2007138584A (ru) 2009-04-27
BRPI0608453A2 (pt) 2009-12-29
US8143295B2 (en) 2012-03-27
EP1863522A4 (en) 2010-11-10
IL185999A0 (en) 2008-08-07
EP1863522A2 (en) 2007-12-12

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