KR20070091568A - 인슐린 유사 성장인자―1의 활성을 가지는 펩타이드 및그의 용도 - Google Patents
인슐린 유사 성장인자―1의 활성을 가지는 펩타이드 및그의 용도 Download PDFInfo
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- KR20070091568A KR20070091568A KR1020070021801A KR20070021801A KR20070091568A KR 20070091568 A KR20070091568 A KR 20070091568A KR 1020070021801 A KR1020070021801 A KR 1020070021801A KR 20070021801 A KR20070021801 A KR 20070021801A KR 20070091568 A KR20070091568 A KR 20070091568A
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Abstract
Description
서열 번호 | 아미노산 서열 | 분석값(질량분석기) | |
분석치 | 이론치 | ||
1 | GFYFNKAAGYGSSSRR | 1770.6 | 1767.9 |
2 | GYGSSSRRAPQT | 1270.88 | 1266.4 |
3 | ESSFRSSDLRRL | 1457.4 | 1452.6 |
4 | CDLRRLEMYC | 1304.8 | 1303.6 |
5 | RRLEMYCAPLKP | 1479.5 | 1476.8 |
성분 | 함량(중량%) |
나노좀화 펩타이드 | 10 |
1,3-부틸렌글리콜 | 6.0 |
글리세린 | 4.0 |
PEG 1500 | 1.0 |
소듐히알루로네이트 | 1.0 |
폴리솔베이트 20 | 0.5 |
에탄올 | 8.0 |
방부제, 색소 | 적량 |
벤조페논-9 | 0.05 |
향 | 미량 |
정제수 | 잔량 |
합계 | 100 |
성분 | 함량(중량%) |
나노좀화 펩타이드 | 20 |
메도우폼오일 | 3.0 |
세테아릴알콜 | 1.5 |
스테아린산 | 1.5 |
글리세릴스테아레이트 | 1.5 |
유동 파라핀 | 10.0 |
밀납 | 2.0 |
폴리솔베이트60 | 0.6 |
솔비탄 세스퀴올레이트 | 2.5 |
스쿠알란 | 3.0 |
1,3-부틸렌글리콜 | 3.0 |
글리세린 | 5.0 |
트리에탄올아민 | 0.5 |
토코페릴아세테이트 | 0.5 |
방부제, 색소 | 적량 |
향 | 적량 |
정제수 | 잔량 |
합계 | 100 |
성분 | 함량(중량%) |
나노좀화 펩타이드 | 20 |
글리세린 | 10.0 |
1,3-부틸렌글리콜 | 5.0 |
PEG 1500 | 2.0 |
알란토인 | 0.1 |
DL-판테놀 | 0.3 |
EDTA-2Na | 0.02 |
히드록시에틸 셀룰로오스 | 0.1 |
소듐히알루로네이트 | 8.0 |
카르복시비닐폴리머 | 0.2 |
트리에탄올아민 | 0.18 |
옥틸도데세스-16 | 0.4 |
에탄올 | 6.0 |
향, 방부제, 색소 | 적량 |
정제수 | 잔량 |
합계 | 100 |
성분 | 함량(중량%) |
IGF-1 미미킹 펩타이드 | 0.005 |
에탄올 | 15 |
글리세린 | 10 |
폴리옥시에칠렌경화피마자유 | 2 |
삭카린 | 0.15 |
안식향산 나트륨 | 0.05 |
향료 | 적량 |
인산2수소나트륨 | 0.1 |
착색제 | 적량 |
정제수 | 72.7 |
성분 | 함량(중량%) |
IGF-1 미미킹 펩타이드 | 0.005 |
제2인산칼슘2수염 | 45 |
실리카 | 2 |
글리세린 | 15 |
카르복시메칠셀룰로오스나트륨 | 1 |
카라기난 | 0.3 |
라우릴황산나트륨 | 1.5 |
삭카린나트륨 | 0.1 |
향료 | 적량 |
파라옥시안식향산나트륨 | 0.01 |
정제수 | 35.09 |
Claims (21)
- 인간 인슐린 유사 성장인자-1(IGF-1)으로부터 유래되고, 서열목록 제2서열 내지 제8서열에 기재된 아미노산 서열로 구성된 군으로부터 선택되는 1종의 아미노산 서열을 포함하는 IGF-1 활성을 나타내는 펩타이드.
- 제 1 항에 있어서, 상기 서열목록 제6서열의 아미노산 서열에서 링커는 Ala-Ala 다이머, 아미노 헥사노산 또는 아미노 부티르산인 것을 특징으로 하는 펩타이드.
- 제 2 항에 있어서, 상기 서열목록 제6서열의 아미노산 서열은 서열목록 제1서열의 아미노산 서열인 것을 특징으로 하는 펩타이드.
- 제 1 항에 있어서, 상기 서열목록 제4서열의 아미노산 서열에서 N-말단 및 C-말단의 Cys 잔기는 이황화결합 되어 있는 것을 특징으로 하는 펩타이드.
- 제 1 항에 있어서, 상기 펩타이드의 C-말단은 히드록시기(-OH) 또는 아미노기(-NH2)로 변형된 것을 특징으로 하는 펩타이드.
- 제 1 항에 있어서, 상기 펩타이드의 N-말단은 아세틸기, 플루오레닐 메톡시 카르보닐기, 포르밀기, 팔미토일기, 미리스틸기, 스테아릴기 및 폴리에틸렌글리콜(PEG)로 구성된 군으로부터 선택되는 보호기가 결합되어 있는 것을 특징으로 하는 펩타이드.
- 상기 제 1 항 내지 제 6 항 중 어느 한 항의 펩타이드를 유효성분으로 포함하는 피부 상태의 개선 또는 치주질환의 치료용 조성물.
- 제 7 항에 있어서, 상기 조성물은 (a) 제 1 항 내지 제 6 항 중 어느 한 항의 펩타이드의 약제학적 유효량; 및 (b) 약제학적으로 허용되는 담체를 포함하는 약제학적 조성물인 것을 특징으로 하는 조성물.
- 제 7 항에 있어서, 상기 조성물은 (a) 제 1 항 내지 제 6 항 중 어느 한 항의 펩타이드의 화장품학적 유효량(cosmetically effective amount); 및 (b) 화장품학적으로 허용되는 담체를 포함하는 화장품 조성물인 것을 특징으로 하는 조성물.
- 제 7 항에 있어서, 상기 피부 상태의 개선은 주름개선, 피부탄력 개선, 피부노화 방지, 탈모 방지 또는 발모촉진, 피부보습 개선, 검버섯 제거 또는 여드름 치료인 것을 특징으로 하는 조성물.
- 제 7 항에 있어서, 상기 조성물은 치주질환의 치료 효능을 가지며, 상기 조성물은 치약(toothpaste), 구강청정용 조성물 또는 구강보호용 조성물인 것을 특징으로 하는 조성물.
- 상기 제 1 항 내지 제 6 항 중 어느 한 항의 펩타이드를 유효성분으로 포함하는 조성물을 대상(subject)에 투여하는 단계를 포함하는 피부 상태를 개선 또는 치주질환을 치료하는 방법.
- 제 12 항에 있어서, 상기 조성물은 (a) 서열목록 제1서열의 아미노산 서열을 포함하는 펩타이드의 약제학적 유효량; 및 (b) 약제학적으로 허용되는 담체를 포함하는 약제학적 조성물인 것을 특징으로 하는 방법.
- 제 12 항에 있어서, 상기 조성물은 (a) 서열목록 제1서열의 아미노산 서열을 포함하는 펩타이드의 화장품학적 유효량(cosmetically effective amount); 및 (b) 화장품학적으로 허용되는 담체를 포함하는 화장품 조성물인 것을 특징으로 하는 방법.
- 제 12 항에 있어서, 상기 피부 상태의 개선은 주름개선, 피부탄력 개선, 피부노화 방지, 탈모 방지 또는 발모촉진, 피부보습 개선, 검버섯 제거 또는 여드름 치료인 것을 특징으로 하는 방법.
- 제 12 항에 있어서, 상기 조성물은 치주질환의 치료 효능을 가지며, 상기 조성물은 치약(toothpaste), 구강청정용 조성물 또는 구강보호용 조성물인 것을 특징으로 하는 방법.
- 피부 상태의 개선 또는 치주질환의 치료용 조성물을 제조하기 위한 상기 제 1 항 내지 제 6 항 중 어느 한 항의 펩타이드의 용도.
- 제 17 항에 있어서, 상기 조성물은 (a) 서열목록 제1서열의 아미노산 서열을 포함하는 펩타이드의 약제학적 유효량; 및 (b) 약제학적으로 허용되는 담체를 포함하는 약제학적 조성물인 것을 특징으로 하는 용도.
- 제 17 항에 있어서, 상기 조성물은 (a) 서열목록 제1서열의 아미노산 서열을 포함하는 펩타이드의 화장품학적 유효량(cosmetically effective amount); 및 (b) 화장품학적으로 허용되는 담체를 포함하는 화장품 조성물인 것을 특징으로 하는 용도.
- 제 17 항에 있어서, 상기 피부 상태의 개선은 주름개선, 피부탄력 개선, 피부노화 방지, 탈모 방지 또는 발모촉진, 피부보습 개선, 검버섯 제거 또는 여드름 치료인 것을 특징으로 하는 용도.
- 제 17 항에 있어서, 상기 조성물은 치주질환의 치료 효능을 가지며, 상기 조성물은 치약(toothpaste), 구강청정용 조성물 또는 구강보호용 조성물인 것을 특징으로 하는 용도.
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KR101669140B1 (ko) * | 2015-04-28 | 2016-10-26 | (주)케어젠 | 항비만 및 항당뇨 효능을 갖는 펩타이드 및 이의 용도 |
KR20190073147A (ko) * | 2017-12-18 | 2019-06-26 | 주식회사 엘지생활건강 | 인슐린유사 성장인자-1의 융합 단백질을 포함하는 피부개선용 화장료 조성물 |
WO2021118323A1 (ko) * | 2019-12-13 | 2021-06-17 | (주)넥스젠바이오텍 | 텐덤 인슐린 유사 성장인자-1 및 이를 유효성분으로 함유하는 탈모방지 또는 발모촉진용 조성물 |
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KR101163171B1 (ko) * | 2009-01-20 | 2012-07-19 | (주)케어젠 | 노긴?유래 펩타이드 및 그의 용도 |
CA2768621C (en) | 2009-07-22 | 2016-04-05 | Ipsen Pharma S.A.S. | Analogues of insulin-like growth factor-1 (igf-1) having amino acid substitution at position 59 |
WO2013020038A2 (en) * | 2011-08-04 | 2013-02-07 | Cynosure, Inc. | Non-uniform beam phototherapeutic dosage determination method |
KR102342629B1 (ko) | 2012-04-18 | 2021-12-22 | 싸이노슈어, 엘엘씨 | 피코초 레이저 장치 및 그를 사용한 표적 조직의 치료 방법 |
WO2013190567A2 (en) | 2012-06-19 | 2013-12-27 | Shome Debraj | Composition and method for an intradermal hair growth solution |
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BR102013025813A2 (pt) * | 2013-10-04 | 2015-08-25 | Sanofi Aventis Farmacêutica Ltda | Composição para tratamento de úlceras diabéticas, processo de preparação da composição e seu uso |
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KR101669140B1 (ko) * | 2015-04-28 | 2016-10-26 | (주)케어젠 | 항비만 및 항당뇨 효능을 갖는 펩타이드 및 이의 용도 |
US10351597B2 (en) | 2015-04-28 | 2019-07-16 | Caregen Co., Ltd. | Peptide with anti-obesity and anti-diabetes activity and use thereof |
US10626145B2 (en) | 2015-04-28 | 2020-04-21 | Caregen Co., Ltd. | Peptide with anti-obesity and anti-diabetes activity and use thereof |
US10738081B2 (en) | 2015-04-28 | 2020-08-11 | Caregen Co., Ltd. | Peptide with anti-obesity and anti-diabetes activity and use thereof |
US11186611B2 (en) | 2015-04-28 | 2021-11-30 | Caregen Co., Ltd. | Peptide with anti-obesity and anti-diabetes activity and use thereof |
KR20190073147A (ko) * | 2017-12-18 | 2019-06-26 | 주식회사 엘지생활건강 | 인슐린유사 성장인자-1의 융합 단백질을 포함하는 피부개선용 화장료 조성물 |
WO2021118323A1 (ko) * | 2019-12-13 | 2021-06-17 | (주)넥스젠바이오텍 | 텐덤 인슐린 유사 성장인자-1 및 이를 유효성분으로 함유하는 탈모방지 또는 발모촉진용 조성물 |
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JP4971373B2 (ja) | 2012-07-11 |
US8263095B2 (en) | 2012-09-11 |
EP1989226A1 (en) | 2008-11-12 |
CN101395179A (zh) | 2009-03-25 |
CN101395179B (zh) | 2013-01-02 |
WO2007102686A1 (en) | 2007-09-13 |
US20090169491A1 (en) | 2009-07-02 |
KR100861914B1 (ko) | 2008-10-09 |
EP2270039B1 (en) | 2013-05-29 |
US20100278756A1 (en) | 2010-11-04 |
WO2007102686A8 (en) | 2010-03-04 |
JP2009529036A (ja) | 2009-08-13 |
EP1989226A4 (en) | 2009-11-18 |
EP2270039A1 (en) | 2011-01-05 |
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