KR20070073958A - 디플루오로뉴클레오시드 및 이의 제조 방법 - Google Patents

디플루오로뉴클레오시드 및 이의 제조 방법 Download PDF

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Publication number
KR20070073958A
KR20070073958A KR1020077012245A KR20077012245A KR20070073958A KR 20070073958 A KR20070073958 A KR 20070073958A KR 1020077012245 A KR1020077012245 A KR 1020077012245A KR 20077012245 A KR20077012245 A KR 20077012245A KR 20070073958 A KR20070073958 A KR 20070073958A
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KR
South Korea
Prior art keywords
formula
deoxy
difluoro
dibenzoate
uridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020077012245A
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English (en)
Korean (ko)
Inventor
안네-루스 본
피에르 마틴
디르크 시필포겔
마르코 빌라
Original Assignee
시코르, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 시코르, 인크. filed Critical 시코르, 인크.
Publication of KR20070073958A publication Critical patent/KR20070073958A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020077012245A 2004-12-08 2005-12-08 디플루오로뉴클레오시드 및 이의 제조 방법 Ceased KR20070073958A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63437604P 2004-12-08 2004-12-08
US60/634,376 2004-12-08

Publications (1)

Publication Number Publication Date
KR20070073958A true KR20070073958A (ko) 2007-07-10

Family

ID=36147231

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077012245A Ceased KR20070073958A (ko) 2004-12-08 2005-12-08 디플루오로뉴클레오시드 및 이의 제조 방법

Country Status (10)

Country Link
US (1) US20060173174A1 (https=)
EP (1) EP1819718A1 (https=)
JP (1) JP2007522151A (https=)
KR (1) KR20070073958A (https=)
CN (1) CN101076535A (https=)
CA (1) CA2586687A1 (https=)
IL (1) IL183702A0 (https=)
MX (1) MX2007006837A (https=)
TW (1) TW200634022A (https=)
WO (1) WO2006063105A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain Compounds, Compositions and Methods
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
JP5687687B2 (ja) 2009-04-06 2015-03-18 大塚製薬株式会社 癌を治療するための（２’−デオキシ−リボフラノシル）−１，３，４，７−テトラヒドロ−（１，３）ジアゼピン−２−オン誘導体
UY32546A (es) 2009-04-06 2010-10-29 Eisai Inc Composiciones y metodos para tratar cancer
AU2010234562B2 (en) 2009-04-06 2016-05-12 Taiho Pharmaceutical Co., Ltd. Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer
CN105693795A (zh) * 2014-08-13 2016-06-22 陈欣 能破坏细胞复制的二氟代核苷类抗癌药的制备方法
WO2025235664A1 (en) * 2024-05-07 2025-11-13 Emory University Purine nucleotide and nucleoside therapeutic compositions and uses related thereto

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH541566A (de) * 1969-04-11 1973-09-15 Schering Ag Verfahren zur Herstellung von Nucleosiden
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
ATE92499T1 (de) * 1984-12-04 1993-08-15 Lilly Co Eli Tumorbehandlung bei saeugetieren.
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
JPH0673086A (ja) * 1992-06-22 1994-03-15 Eli Lilly & Co 立体選択的な陰イオングリコシル化法
US5594124A (en) * 1992-06-22 1997-01-14 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US6828346B2 (en) * 1999-10-25 2004-12-07 Supergen, Inc. Methods for administration of paclitaxel
US7265096B2 (en) * 2002-11-04 2007-09-04 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
CN1228342C (zh) * 2003-04-08 2005-11-23 深圳市汉德森技术有限公司 以1，6－脱水－β－D－葡萄糖为原料制备2'－脱氧－2'，2'－二氟－β－核胞苷或其药用盐的方法

Also Published As

Publication number Publication date
IL183702A0 (en) 2007-09-20
CN101076535A (zh) 2007-11-21
US20060173174A1 (en) 2006-08-03
JP2007522151A (ja) 2007-08-09
WO2006063105A1 (en) 2006-06-15
CA2586687A1 (en) 2006-06-15
EP1819718A1 (en) 2007-08-22
MX2007006837A (es) 2007-10-23
TW200634022A (en) 2006-10-01

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