MX2007006837A - Difluoronucleosidos y proceso de preparacion de los mismos. - Google Patents

Difluoronucleosidos y proceso de preparacion de los mismos.

Info

Publication number
MX2007006837A
MX2007006837A MX2007006837A MX2007006837A MX2007006837A MX 2007006837 A MX2007006837 A MX 2007006837A MX 2007006837 A MX2007006837 A MX 2007006837A MX 2007006837 A MX2007006837 A MX 2007006837A MX 2007006837 A MX2007006837 A MX 2007006837A
Authority
MX
Mexico
Prior art keywords
protected
base
preparation
group
difluorofuranose
Prior art date
Application number
MX2007006837A
Other languages
English (en)
Inventor
Marco Villa
Anne-Ruth Born
Pierre Martin
Dirk Spielvogel
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Publication of MX2007006837A publication Critical patent/MX2007006837A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporciona un proceso estereoselectivo de preparacion de 2??,2??-difluoronucleosido. En el proceso, se acopla el 2??,2??-difluorofuranosa con una base seleccionada del grupo que consiste en derivados de pirimidina y de purina en presencia de acido de Lewis, en donde el 2??,2??-difluorofuranosa protegido tiene una posicion 1 saliente y 3- y 5- tienen posicion de grupos protectores y, cuando la base comprende uno o mas atomos de oxigeno, la base es una base protegida, en donde cada atomo de oxigeno esta protegido con un grupo protector.
MX2007006837A 2004-12-08 2005-12-08 Difluoronucleosidos y proceso de preparacion de los mismos. MX2007006837A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63437604P 2004-12-08 2004-12-08
PCT/US2005/044369 WO2006063105A1 (en) 2004-12-08 2005-12-08 Difluoronucleosides and process for preparation thereof

Publications (1)

Publication Number Publication Date
MX2007006837A true MX2007006837A (es) 2007-10-23

Family

ID=36147231

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007006837A MX2007006837A (es) 2004-12-08 2005-12-08 Difluoronucleosidos y proceso de preparacion de los mismos.

Country Status (10)

Country Link
US (1) US20060173174A1 (es)
EP (1) EP1819718A1 (es)
JP (1) JP2007522151A (es)
KR (1) KR20070073958A (es)
CN (1) CN101076535A (es)
CA (1) CA2586687A1 (es)
IL (1) IL183702A0 (es)
MX (1) MX2007006837A (es)
TW (1) TW200634022A (es)
WO (1) WO2006063105A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
ES2628609T3 (es) 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combinación de fármacos antineoplásicos a base de citidina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer
CA2757744C (en) 2009-04-06 2018-02-13 Eisai Inc. Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer
US8324180B2 (en) 2009-04-06 2012-12-04 Eisai Inc. Compositions and methods for treating cancer
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
CN105693795A (zh) * 2014-08-13 2016-06-22 陈欣 能破坏细胞复制的二氟代核苷类抗癌药的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU452961A3 (ru) * 1969-04-11 1974-12-05 Шеринг Аг. (Фирма) Способ получени пиримидиннуклеозидов
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
IL77133A (en) * 1984-12-04 1991-01-31 Lilly Co Eli Antineoplastic pharmaceutical compositions containing pentofuranoside derivatives,some new such compounds and their preparation
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5594124A (en) * 1992-06-22 1997-01-14 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
JPH0673086A (ja) * 1992-06-22 1994-03-15 Eli Lilly & Co 立体選択的な陰イオングリコシル化法
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US6828346B2 (en) * 1999-10-25 2004-12-07 Supergen, Inc. Methods for administration of paclitaxel
EP1567169A4 (en) * 2002-11-04 2009-10-21 Xenoport Inc GEMCITABINE PROMOTERS, THEIR PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
CN1228342C (zh) * 2003-04-08 2005-11-23 深圳市汉德森技术有限公司 以1，6－脱水－β－D－葡萄糖为原料制备2'－脱氧－2'，2'－二氟－β－核胞苷或其药用盐的方法

Also Published As

Publication number Publication date
WO2006063105A1 (en) 2006-06-15
IL183702A0 (en) 2007-09-20
EP1819718A1 (en) 2007-08-22
CN101076535A (zh) 2007-11-21
CA2586687A1 (en) 2006-06-15
US20060173174A1 (en) 2006-08-03
JP2007522151A (ja) 2007-08-09
TW200634022A (en) 2006-10-01
KR20070073958A (ko) 2007-07-10

Similar Documents

Publication Publication Date Title
MY145447A (en) Use of 2-6(3-amino-piperidin-1-yl)-3-methyl-2, 4-dioxo-3, 4-dihydrp-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile
WO2006084017A3 (en) Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
EP1604665A4 (en) C-KIT KINASE HEMMER
WO2006044958A8 (en) Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (crf) receptor antagonists
MX2007006837A (es) Difluoronucleosidos y proceso de preparacion de los mismos.
IL144668A0 (en) The use of 4-h-1-benzopyran-4- one derivatives as inhibitors of smooth muscle cell proliferation
MY144322A (en) 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
TW200635930A (en) Bicyclic pyrrole derivatives
AU2003264060A1 (en) Phenacyl xanthine derivatives as dpp-iv inhibitor
RS20050137A (en) 8-(3-amino-piperidin-1-yl)-xanthines, the production thereof and the use of the same as medicaments
HK1064096A1 (en) Purine derivatives as a2b adenosine receptor antagonists.
TW200607806A (en) Pyrimidines as plk inhibitors
WO2003074500A3 (en) N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as ddp-iv inhibitors
WO2007143705A3 (en) Organic compounds
TNSN05254A1 (en) Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and application of same in therapeutics
TW200612958A (en) Substituted imidazole derivatives
MY136242A (en) Purine derivatives
IL163781A0 (en) Purine derivatives as kinase inhibitors
TW200724540A (en) Heterocyclic antiviral compounds
DE502004007000D1 (de) Stickstoff substituierte hexahydro-pyrazino 1,2-a pyrimidin-4,7-dionderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
MY142441A (en) Azole derivatives as inhibitors of lipases and phospholipases
TN2009000362A1 (en) Weekly administration of dipeptidyl peptidase inhibitors
AU2003238026A1 (en) Shaped articles with improved stability
UA87835C2 (en) 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use in the form of a dpp inhibitor
RS20070095A (en) Alkyliden-tetrahydronaphthalene derivatives, method for their production and their use as anti-inflammatory agents