KR20070047770A - 펩티드 항생제 및 이의 제조방법 - Google Patents

펩티드 항생제 및 이의 제조방법 Download PDF

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Publication number
KR20070047770A
KR20070047770A KR1020077002649A KR20077002649A KR20070047770A KR 20070047770 A KR20070047770 A KR 20070047770A KR 1020077002649 A KR1020077002649 A KR 1020077002649A KR 20077002649 A KR20077002649 A KR 20077002649A KR 20070047770 A KR20070047770 A KR 20070047770A
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KR
South Korea
Prior art keywords
dab
peptide
thr
fmoc
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020077002649A
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English (en)
Korean (ko)
Inventor
리차드 에이 리스
노린 프란시스
윌리엄 브이 쿠란
도날드 비 보더스
하워드 자롤멘
Original Assignee
바이오소스 팜 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 바이오소스 팜 인코포레이티드 filed Critical 바이오소스 팜 인코포레이티드
Publication of KR20070047770A publication Critical patent/KR20070047770A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020077002649A 2004-07-01 2005-07-01 펩티드 항생제 및 이의 제조방법 Ceased KR20070047770A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/881,160 US20060004185A1 (en) 2004-07-01 2004-07-01 Peptide antibiotics and peptide intermediates for their prepartion
US10/881,160 2004-07-01

Publications (1)

Publication Number Publication Date
KR20070047770A true KR20070047770A (ko) 2007-05-07

Family

ID=35514884

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077002649A Ceased KR20070047770A (ko) 2004-07-01 2005-07-01 펩티드 항생제 및 이의 제조방법

Country Status (15)

Country Link
US (2) US20060004185A1 (https=)
EP (2) EP2332965A1 (https=)
JP (2) JP2008505858A (https=)
KR (1) KR20070047770A (https=)
CN (1) CN101010336A (https=)
AU (1) AU2005326770B2 (https=)
BR (1) BRPI0512941A (https=)
CA (1) CA2571944A1 (https=)
IL (1) IL180458A0 (https=)
MX (1) MXPA06015239A (https=)
NO (1) NO20070563L (https=)
NZ (2) NZ579261A (https=)
RU (2) RU2428429C2 (https=)
WO (1) WO2006083317A2 (https=)
ZA (1) ZA200610818B (https=)

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US9096649B2 (en) 2008-02-08 2015-08-04 Northern Antibiotics Ltd. Polymyxin derivatives and uses thereof
US8329645B2 (en) * 2008-02-08 2012-12-11 Northern Antibiotics Ltd. Polymyxin derivatives and uses thereof
JP5387567B2 (ja) * 2008-03-14 2014-01-15 アステラス製薬株式会社 環状化合物およびその塩
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WO2010130007A1 (en) * 2009-05-14 2010-11-18 Monash University Antimicrobial compounds
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WO2012051663A1 (en) * 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
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JP6643758B2 (ja) 2013-05-22 2020-02-12 スペロ・セラピューティクス・インコーポレーテッド 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用
CN103396475B (zh) * 2013-08-06 2015-08-26 深圳翰宇药业股份有限公司 一种纯固相合成多肽类抗生素Colistin的方法
JP6754997B2 (ja) * 2013-08-26 2020-09-16 国立大学法人 東京大学 大環状ペプチド、その製造方法、及び大環状ペプチドライブラリを用いるスクリーニング方法
RU2740190C2 (ru) * 2014-03-11 2021-01-12 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками
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KR102480965B1 (ko) 2016-09-13 2022-12-26 알레간 인코포레이티드 안정화된 비단백질 클로스트리듐 독소 조성물
JP6975433B2 (ja) * 2016-12-16 2021-12-01 中国医学科学院医薬生物技術研究所 ポリミキシン誘導体及びその製造方法と応用
CN106868079B (zh) * 2017-04-26 2020-12-08 山东鲁抗医药股份有限公司 发酵硫酸多粘菌素b用培养基及发酵生产硫酸多粘菌素b的方法
AU2018359018B2 (en) * 2017-11-02 2022-11-24 The University Of Queensland Peptide antibiotics
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CN111410682A (zh) * 2020-04-28 2020-07-14 梯尔希（南京）药物研发有限公司 多粘菌素b相关化合物的环化制备方法
CN113215185B (zh) * 2021-04-22 2022-04-29 浙江工业大学 一种用于重组表达棘白菌素b脱酰基酶的重组基因序列
CN113174398B (zh) * 2021-04-22 2022-04-29 浙江工业大学 一种用于重组表达棘白菌素b脱酰基酶的表达盒及应用
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RU2428429C2 (ru) 2011-09-10
IL180458A0 (en) 2007-06-03
WO2006083317A3 (en) 2007-01-18
US20060004185A1 (en) 2006-01-05
EP2332965A1 (en) 2011-06-15
CA2571944A1 (en) 2006-08-10
NZ579261A (en) 2011-02-25
WO2006083317A2 (en) 2006-08-10
RU2007103811A (ru) 2008-08-10
MXPA06015239A (es) 2007-12-10
NZ552730A (en) 2009-09-25
ZA200610818B (en) 2008-07-30
EP1761554A2 (en) 2007-03-14
JP2008505858A (ja) 2008-02-28
AU2005326770B2 (en) 2011-11-03
RU2011115077A (ru) 2012-10-20
JP2011256189A (ja) 2011-12-22
US8889826B2 (en) 2014-11-18
WO2006083317A9 (en) 2007-03-01
AU2005326770A1 (en) 2006-08-10
CN101010336A (zh) 2007-08-01
BRPI0512941A (pt) 2007-10-30
US20080207874A1 (en) 2008-08-28
NO20070563L (no) 2007-03-27

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