KR20070047757A - 아데노바이러스-매개된 유전자 전달에 의해 종양 괴사인자-관련된 아폽토시스-유도 리간드(trail)를생산하도록 조작된 종양-조직지향성 세포 - Google Patents

아데노바이러스-매개된 유전자 전달에 의해 종양 괴사인자-관련된 아폽토시스-유도 리간드(trail)를생산하도록 조작된 종양-조직지향성 세포 Download PDF

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KR20070047757A
KR20070047757A KR1020077000005A KR20077000005A KR20070047757A KR 20070047757 A KR20070047757 A KR 20070047757A KR 1020077000005 A KR1020077000005 A KR 1020077000005A KR 20077000005 A KR20077000005 A KR 20077000005A KR 20070047757 A KR20070047757 A KR 20070047757A
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cells
trail
tumor
tissue
cell
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Korean (ko)
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알레산드로 엠. 지아니
카르멜로 카를로-스텔라
프란세스코 콜로타
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돔페 파르마 에스.피.에이.
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    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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KR1020077000005A 2004-07-29 2005-07-21 아데노바이러스-매개된 유전자 전달에 의해 종양 괴사인자-관련된 아폽토시스-유도 리간드(trail)를생산하도록 조작된 종양-조직지향성 세포 Ceased KR20070047757A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04017907.9 2004-07-29
EP04017907A EP1621550A1 (en) 2004-07-29 2004-07-29 Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Publications (1)

Publication Number Publication Date
KR20070047757A true KR20070047757A (ko) 2007-05-07

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KR1020077000005A Ceased KR20070047757A (ko) 2004-07-29 2005-07-21 아데노바이러스-매개된 유전자 전달에 의해 종양 괴사인자-관련된 아폽토시스-유도 리간드(trail)를생산하도록 조작된 종양-조직지향성 세포

Country Status (24)

Country Link
US (1) US20070264231A1 (enExample)
EP (2) EP1621550A1 (enExample)
JP (1) JP5042826B2 (enExample)
KR (1) KR20070047757A (enExample)
CN (1) CN101076540B (enExample)
AT (1) ATE455847T1 (enExample)
AU (1) AU2005266543B2 (enExample)
BR (1) BRPI0513855A (enExample)
CA (1) CA2571426A1 (enExample)
DE (1) DE602005019050D1 (enExample)
DK (1) DK1771468T3 (enExample)
ES (1) ES2340400T3 (enExample)
HR (1) HRP20100227T1 (enExample)
IL (1) IL180233A (enExample)
MX (1) MX2007001152A (enExample)
NO (1) NO20070956L (enExample)
NZ (1) NZ552223A (enExample)
PL (1) PL1771468T3 (enExample)
PT (1) PT1771468E (enExample)
RS (1) RS51381B (enExample)
RU (1) RU2390558C2 (enExample)
SI (1) SI1771468T1 (enExample)
WO (1) WO2006010558A1 (enExample)
ZA (1) ZA200701231B (enExample)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
BRPI0510886A (pt) * 2004-06-18 2007-12-26 Genentech Inc método para aumentar a apoptose ou a citotoxicidade em células de mamìferos
DE102006020307A1 (de) * 2006-05-03 2007-11-08 Martin-Luther-Universität Halle-Wittenberg TNF-related apoptosis-including (TRAIL)stabil transgen exprimierende mesenchymale Stammzellen, Verfahren zu ihrer Herstellung und zu ihrer Verwendung
WO2008142862A1 (ja) * 2007-05-18 2008-11-27 National University Corporation Asahikawa Medical College 血管内皮前駆細胞の移植による抗がん療法
CN102154213B (zh) * 2011-01-19 2012-07-25 郑骏年 一种运载荷载细胞因子的双调控溶瘤腺病毒的新型cik细胞
US20140369979A1 (en) * 2012-02-01 2014-12-18 Postech Academy-Industry Foundation Vector simultaneously expressing dodecameric trail and hsv-tk suicide genes, and anticancer stem cell therapeutic agent using same
CN103288966B (zh) * 2013-05-17 2015-01-21 华侨大学 一种融合受体及其用于治疗大肠癌的基因药物
RU2552609C1 (ru) * 2013-10-28 2015-06-10 Федеральное государственное бюджетное учреждение науки Институт молекулярной биотехнологии им. В.А. Энгельгардта Российской академии наук (ИМБ РАН) Способ получения системы направленной доставки белковых молекул (онколитических белков) в опухолевые ткани на основе активированных лимфоцитов
RU2716821C2 (ru) 2014-10-24 2020-03-17 Калиди Биотерапьютикс, Инк. Комбинированный иммунотерапевтический подход к лечению рака
EP3971284B1 (en) * 2015-07-29 2023-11-08 ONK Therapeutics Limited Modified natural killer cells and natural killer cell lines having increased cytotoxicity
US10906951B2 (en) 2015-07-29 2021-02-02 Onk Therapeutics Limited Modified natural killer cells and natural killer cell lines having increased cytotoxicity
WO2019232631A1 (en) * 2018-06-06 2019-12-12 Stemcell Technologies Canada Inc. Kits, compositions and methods for myeloid-derived suppressor cell enrichment
US12220465B2 (en) 2018-11-28 2025-02-11 Washington University Compositions and methods for targeted treatment and imaging of cancer or tumors
WO2020188105A1 (en) 2019-03-21 2020-09-24 Onk Therapeutics Limited Modified immune effector cells with increased resistance to cell death
EP3712257A1 (en) 2019-03-21 2020-09-23 ONK Therapeutics Limited Modified natural killer cells with increased resistance to cell death
WO2021209625A1 (en) 2020-04-17 2021-10-21 Onk Therapeutics Limited High potency natural killer cells

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US5879672A (en) * 1994-10-07 1999-03-09 Regeneron Pharmaceuticals, Inc. Tie-2 ligand 1
AU747602B2 (en) * 1997-06-04 2002-05-16 Oxford Biomedica (Uk) Limited Vector
JP2004526666A (ja) * 2000-09-11 2004-09-02 マスク ファウンデーション フォー リサーチ デヴェロップメント アポトーシスの選択的誘導によって腫瘍を治療するための組成物及び方法
AU2001297677B2 (en) * 2000-10-24 2007-07-05 Immunex Corporation Method for dendritic cells based immunotherapy of tumors using combination therapy
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
JP4493882B2 (ja) * 2001-06-19 2010-06-30 株式会社カネカ 抗原およびこの抗原を識別するモノクローナル抗体

Also Published As

Publication number Publication date
EP1771468A1 (en) 2007-04-11
BRPI0513855A (pt) 2008-05-20
ZA200701231B (en) 2008-08-27
RS51381B (sr) 2011-02-28
AU2005266543B2 (en) 2012-02-02
MX2007001152A (es) 2007-04-18
DE602005019050D1 (de) 2010-03-11
ES2340400T3 (es) 2010-06-02
IL180233A0 (en) 2007-07-04
JP5042826B2 (ja) 2012-10-03
RU2390558C2 (ru) 2010-05-27
US20070264231A1 (en) 2007-11-15
DK1771468T3 (da) 2010-05-25
EP1771468B1 (en) 2010-01-20
SI1771468T1 (sl) 2010-07-30
CN101076540B (zh) 2012-10-24
WO2006010558A1 (en) 2006-02-02
IL180233A (en) 2010-12-30
WO2006010558A8 (en) 2006-08-24
AU2005266543A1 (en) 2006-02-02
RU2007107369A (ru) 2008-09-10
JP2008507961A (ja) 2008-03-21
NO20070956L (no) 2007-02-20
NZ552223A (en) 2009-01-31
CA2571426A1 (en) 2006-02-02
PL1771468T3 (pl) 2010-07-30
HRP20100227T1 (hr) 2010-07-31
CN101076540A (zh) 2007-11-21
ATE455847T1 (de) 2010-02-15
PT1771468E (pt) 2010-04-20
EP1621550A1 (en) 2006-02-01
HK1110874A1 (en) 2008-07-25

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