KR20070004026A - 선택적 스플라이싱을 이용하여 진핵 세포에서 폴리펩티드다량체를 발현하기 위한 방법 및 구축물 - Google Patents
선택적 스플라이싱을 이용하여 진핵 세포에서 폴리펩티드다량체를 발현하기 위한 방법 및 구축물 Download PDFInfo
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- KR20070004026A KR20070004026A KR1020067021005A KR20067021005A KR20070004026A KR 20070004026 A KR20070004026 A KR 20070004026A KR 1020067021005 A KR1020067021005 A KR 1020067021005A KR 20067021005 A KR20067021005 A KR 20067021005A KR 20070004026 A KR20070004026 A KR 20070004026A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Virology (AREA)
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- Tropical Medicine & Parasitology (AREA)
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- Urology & Nephrology (AREA)
- Psychology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55347804P | 2004-03-15 | 2004-03-15 | |
| US60/553,478 | 2004-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20070004026A true KR20070004026A (ko) | 2007-01-05 |
Family
ID=34994241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067021005A Ceased KR20070004026A (ko) | 2004-03-15 | 2005-03-15 | 선택적 스플라이싱을 이용하여 진핵 세포에서 폴리펩티드다량체를 발현하기 위한 방법 및 구축물 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7569362B2 (https=) |
| EP (1) | EP1733034A4 (https=) |
| JP (1) | JP2007529223A (https=) |
| KR (1) | KR20070004026A (https=) |
| CN (1) | CN1961071A (https=) |
| AU (1) | AU2005222963B2 (https=) |
| BR (1) | BRPI0508862A (https=) |
| CA (1) | CA2559280A1 (https=) |
| IL (1) | IL178051A (https=) |
| WO (1) | WO2005089285A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2355459B (en) | 1999-11-29 | 2001-09-26 | Isis Innovation | A dominant conditional lethal genetic system |
| GB2402675B (en) * | 2003-05-12 | 2008-02-20 | Oxitec Ltd | Resistance dilution |
| GB2403475B (en) * | 2003-07-01 | 2008-02-06 | Oxitec Ltd | Stable integrands |
| GB2404382B (en) | 2003-07-28 | 2008-01-30 | Oxitec Ltd | Pest control |
| CA2559280A1 (en) * | 2004-03-15 | 2005-09-29 | Biogen Idec Ma Inc. | Methods and constructs for expressing polypeptide multimers in eukaryotic cells using alternative splicing |
| US20090183269A1 (en) * | 2006-02-10 | 2009-07-16 | Oxitec Limited | Gene expression system using alternative splicing in insects |
| GB2443186A (en) | 2006-10-25 | 2008-04-30 | Oxitec Ltd | Expression system for mediating alternative splicing |
| AU2007245164A1 (en) | 2006-03-28 | 2007-11-08 | Biogen Idec Ma Inc. | Anti-IGF-IR antibodies and uses thereof |
| US20090305343A1 (en) * | 2006-05-16 | 2009-12-10 | Millegen | Method For Expressing Polypeptides In Eukaryotic Cells Using Alternative Splicing |
| EP2027273B1 (en) * | 2006-05-17 | 2016-04-13 | F. Hoffmann-La Roche AG | Polypeptide producing cells |
| US20080045419A1 (en) * | 2006-08-18 | 2008-02-21 | University Of North Texas Health Science Center At Fort Worth | Screening Assay |
| SG185302A1 (en) * | 2007-10-15 | 2012-11-29 | Chugai Pharmaceutical Co Ltd | Method for production of antibody |
| US7947495B2 (en) * | 2007-11-01 | 2011-05-24 | Abbott Biotherapeutics Corp. | Immunoglobulin display vectors |
| KR100907221B1 (ko) * | 2009-01-22 | 2009-07-10 | 한국과학기술원 | 새로운 조성의 황색 발광 Ce3+부활 칼슘 실리케이트 황색형광체를 포함하는 백색 발광 다이오드 |
| US9481882B2 (en) | 2010-03-31 | 2016-11-01 | Tokyo University Of Science Foundation | Constitution of tool for analyzing biomolecular interaction and analysis method using same |
| WO2013067057A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
| CN104053671A (zh) | 2011-11-01 | 2014-09-17 | 生态学有限公司 | 治疗癌症的抗体和方法 |
| US9221907B2 (en) | 2011-11-01 | 2015-12-29 | Bionomics Inc. | Anti-GPR49 monoclonal antibodies |
| US10598653B2 (en) | 2011-11-01 | 2020-03-24 | Bionomics Inc. | Methods of blocking cancer stem cell growth |
| ES2791758T3 (es) * | 2011-12-22 | 2020-11-05 | Hoffmann La Roche | Organización de vectores de expresión, procedimientos de generación de células de producción novedosos y su uso para la producción recombinante de polipéptidos |
| GB2500113A (en) | 2012-03-05 | 2013-09-11 | Oxitec Ltd | Arthropod male germline gene expression system |
| GB201303932D0 (en) | 2013-03-05 | 2013-04-17 | Oxitec Ltd | Muscle actin promoter |
| AU2014246731A1 (en) * | 2013-03-30 | 2015-11-19 | Usha Biotech Limited | Methods and constructs for expressing biologically active proteins in mammalian cells |
| KR20200044154A (ko) * | 2013-08-06 | 2020-04-28 | 아이크노스 사이언스 에스. 아. | 진핵세포의 폴리펩티드 발현 방법 및 발현 구조체 |
| CA2944649C (en) | 2014-04-04 | 2022-06-21 | Bionomics, Inc. | Humanized antibodies that bind lgr5 |
| GB2526867A (en) | 2014-06-05 | 2015-12-09 | Oxitec Ltd | Gene expression system |
| WO2017161414A1 (en) | 2016-03-22 | 2017-09-28 | Bionomics Limited | Administration of an anti-lgr5 monoclonal antibody |
| BR112019002771A2 (pt) | 2016-08-12 | 2019-05-14 | Oxitec Ltd | polinucleotídeo de módulo de controle de união de doublesex, sistema de expressão de gene, plasmídeo vetor de expressão, inseto geneticamente engenheirado, métodos para produzir insetos geneticamente engenheirados, para cultivar seletivamente insetos macho geneticamente engenheirados, para reduzir uma população de inseto selvagem, para criar um mosquito aedes aegypti transgênico e para detectar a presença de uma molécula de dna, local alvo cromossômico de aedes aegypti, mosquito aedes aegypti geneticamente engenheirado, molécula de dna, e, kit de detecção de dna. |
| CN109790214B (zh) | 2016-09-29 | 2022-09-06 | 豪夫迈·罗氏有限公司 | 用于选择产生多肽的细胞的改进方法 |
| AR117409A1 (es) | 2018-03-29 | 2021-08-04 | Oxitec Ltd | Noctuidas autolimitantes |
| EP3823981A4 (en) * | 2018-07-17 | 2022-04-06 | Neuromyon Inc. | TREATMENT OF NEUROPATHY WITH DNA CONSTRUCTS EXPRESSING IGF-1 ISOFORMS |
| CN115279902A (zh) * | 2019-08-30 | 2022-11-01 | 贝勒医学院 | 用于调控基因表达的系统 |
| CN114150021B (zh) * | 2021-11-26 | 2022-10-28 | 劲帆生物医药科技(武汉)有限公司 | 一种包含重叠开放阅读框的基因的表达盒及其在昆虫细胞中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2759053A1 (de) * | 1977-12-30 | 1979-07-12 | Uhlin | Verfahren zum herstellen von genprodukten von plasmid-dns |
| GB2048894A (en) * | 1979-05-11 | 1980-12-17 | Gist Brocades Nv | Plasmid |
| JPS58192900A (ja) * | 1982-05-04 | 1983-11-10 | Ajinomoto Co Inc | 複合プラスミド |
| US5043270A (en) * | 1989-03-31 | 1991-08-27 | The Board Of Trustees Of The Leland Stanford Junior University | Intronic overexpression vectors |
| EP0501914A1 (en) * | 1991-02-25 | 1992-09-02 | Ciba-Geigy Ag | Improved yeast vectors |
| US5587308A (en) * | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| US5561053A (en) * | 1994-08-05 | 1996-10-01 | Genentech, Inc. | Method for selecting high-expressing host cells |
| WO1999024596A1 (en) * | 1997-11-12 | 1999-05-20 | Valentis, Inc. | Expression plasmids for multiepitope nucleic acid-based vaccines |
| US6228360B1 (en) * | 1998-08-19 | 2001-05-08 | Ajinomoto Co., Inc. | Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody |
| US6900010B2 (en) * | 1999-01-25 | 2005-05-31 | Musc Foundation For Research Development | Compositions and methods for detecting human immunodeficiency virus |
| EP1103614B1 (en) * | 1999-06-04 | 2010-06-02 | Nippon Institute for Biological Science | Novel plasmid vector |
| WO2004046340A2 (en) * | 2002-11-14 | 2004-06-03 | Genentech, Inc. | Intron fusion construct and method of using for selecting high-expressing production cell lines |
| DK1594955T3 (da) * | 2003-02-14 | 2012-06-25 | Biogen Idec Inc | Ekspressionskassette og vektor til transient eller stabil ekspression af eksogene molekyler |
| CA2559280A1 (en) * | 2004-03-15 | 2005-09-29 | Biogen Idec Ma Inc. | Methods and constructs for expressing polypeptide multimers in eukaryotic cells using alternative splicing |
-
2005
- 2005-03-15 CA CA002559280A patent/CA2559280A1/en not_active Abandoned
- 2005-03-15 BR BRPI0508862-3A patent/BRPI0508862A/pt not_active IP Right Cessation
- 2005-03-15 KR KR1020067021005A patent/KR20070004026A/ko not_active Ceased
- 2005-03-15 JP JP2007504008A patent/JP2007529223A/ja active Pending
- 2005-03-15 EP EP05730385A patent/EP1733034A4/en not_active Withdrawn
- 2005-03-15 AU AU2005222963A patent/AU2005222963B2/en not_active Ceased
- 2005-03-15 CN CNA2005800156216A patent/CN1961071A/zh active Pending
- 2005-03-15 US US11/079,933 patent/US7569362B2/en not_active Expired - Lifetime
- 2005-03-15 WO PCT/US2005/008473 patent/WO2005089285A2/en not_active Ceased
-
2006
- 2006-09-12 IL IL178051A patent/IL178051A/en active IP Right Grant
-
2009
- 2009-06-05 US US12/479,144 patent/US20100009410A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0508862A (pt) | 2007-09-04 |
| AU2005222963B2 (en) | 2009-10-29 |
| IL178051A0 (en) | 2006-12-31 |
| EP1733034A2 (en) | 2006-12-20 |
| AU2005222963A1 (en) | 2005-09-29 |
| IL178051A (en) | 2010-12-30 |
| US20100009410A1 (en) | 2010-01-14 |
| CN1961071A (zh) | 2007-05-09 |
| WO2005089285A2 (en) | 2005-09-29 |
| EP1733034A4 (en) | 2010-01-20 |
| JP2007529223A (ja) | 2007-10-25 |
| CA2559280A1 (en) | 2005-09-29 |
| US20050221430A1 (en) | 2005-10-06 |
| US7569362B2 (en) | 2009-08-04 |
| WO2005089285A3 (en) | 2006-01-19 |
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