KR20060123291A - 신규한 비정형 폐렴-원인성 바이러스 - Google Patents

Abstract

본 발명은 바이러스학 분야에 관한 것이다. 본 발명은 코로나바이러스 및 그들의 성분의 군 내의 신규한 분리된 본질적으로 포유동물의 양성-센스 단일가닥 RNA 바이러스(EMCR-CoV)를 제공한다.

코로나바이러스, EMCR-CoV, 양성-센스 단일가닥 RNA 바이러스

Description

신규한 비정형 폐렴-원인성 바이러스{NOVEL ATYPICAL PNEUMONIA-CAUSING VIRUS}

최근, SARS(중증 급성 호흡기 증후근) 또는 다른 알려진 바이러스 감염에 기인한다고 할 수 없는 호흡기 질병(비정형 폐렴)이 8개월된 환자에게서 진단되었다. 그 환자는 인플루엔자, 파라인플루엔자, 볼거리 및 RSV에 대해 음성으로 분석되었고 질환은 SARS와 매우 유사한 바이러스에 기인하는 것으로 동정되었다.

질병의 기원을 추적하고, 그 역학을 모니터하고 질병의 가능한 확산을 막기 위해, 초기 단계에서 폐렴의 바이러스성 원인을 인식할 수 있는 것이 매우 중요하다. 특히, 중증 질환이 바이러스에 기인한다는 것이 밝혀지면, 진단 수단 및 가능한 치료법의 개발을 위해, 가능한 한 빨리 바이러스의 신원을 검출할 필요가 있다. SARS 역학은 이 질병의 확산을 막기 위해 적시에 효과적인 격리조치 및 초기 검역예방을 취하기 위해 초기 진단을 얻는 것이 중요하다는 것을 나타낸다.

추가로, 질환을 일으키는 바이러스의 동정은 백신의 개발을 가능하게 하고, 이것은 감염될 수 있는 위험에 있는 사람들을 보호하기 위한 예방에 사용될 수 있다. 그리고, 마지막으로, 원인 바이러스에 대한 지식은 치료대책을 개발할 수 있게 한다.

그러므로, 일반적으로 바이러스성 폐렴 및 특별히는 신규한 질환-원인성 감 염성 약제에 대해, 특히 이 약제가 바이러스인 것으로 보일 때의 진단 수단과 치료법의 개발이 크게 요구된다.

본 발명은 분리된 본질적으로 코로나바이러스에 속하는 포유동물 양성-센스 단일가닥 RNA 바이러스의 뉴클레오티드 서열을 제공하고, 이것은 신규 질환에 대한 원인이 되는 인자이고, 이하에서 EMCR-CoV로 불린다. 바이러스(도 2a 및 2b)의 매트릭스 및 핵 캡시드 유전자 서열의 계통분석으로부터, 바이러스는 PEDV(돼지 유행성 설사 바이러스), HCoV-229E(인간 코로나바이러스 229E, PRCoV(돼지 호흡기 코로나바이러스), TGEV(전염성 위장염 바이러스), CaCoV(개 코로나바이러스) 및 FeCoV(고양이 코로나바이러스)에 의해 형성된 군의 독특한 맴버인 것으로 보인다. 아미노산 동정 매트릭스를 기초로, 인간 코로나바이러스 229E는 가장 근접한 관련물(PEDV에 약간 더 밀접한 것으로 보이는 매트릭스를 제외한 모든 ORFs의 경우-도 3 참조)인 것으로 보인다.

비록 계통분석이 바이러스의 동정에 편리한 방법을 제공하지만, 어느 정도 더 조악하지만 상기 바이러스 또는 바이러스 단백질 또는 상기 바이러스로부터의 핵산을 동정하는 몇몇 다른 가능한 직접적인 방법이 또한 제공된다. 경험적으로, EMCR-코로나바이러스는 본 명세서에서 서열에 의해 동정된 바이러스성 단백질 또는 핵산과 비교한, 동정되어질 바이러스, 단백질 또는 핵산의 상동률에 의해 동정될 수 있다. 일반적으로 바이러스종, 특히 RNA 바이러스 종은 종종 상기 바이러스의 클러스터가 그 맴버들 중에 이종성을 나타내는 유사 종을 구성한다는 것이 알려져 있다. 그러므로, 각각의 분리물은 여기서 제공된 분리물의 서열과 다소 다른 관련 백분률을 가질 수 있다는 것이 예상된다.

바이러스 분리물을 도 1에 기재된 바와 같은 서열과 비교하기 원하는 경우, 본 발명은, 상기 바이러스의 핵산서열을 결정하고 그리고 상기 핵산서열이 PEDV, 229E, PRCoV, TGEV, CaCoV 및 FeCoV와 비교하여 아래에서 확인되는 바와 같이 핵산에 대해 동정된 백분률 보다 높은, 기록된 서열에 대한 핵산 동일성 백분률을 갖는다는 것을 결정함에 의해, 코로나바이러스에 속하고 그것에 계통적으로 상응하는 것으로 동정가능한 분리된 본질적으로 포유동물의 양성-센스 단일가닥 RNA 바이러스(EMCR-CoV)를 제공한다. 한편, 상기 바이러스의 아미노산 서열을 결정하고 상기 아미노산 서열이 PEDV, 229E, PRCoV, TGEV, CaCoV 및 FeCoV와 비교하여 아래에서 제공된 백분률보다 높은, 서열에 대한 아미노산 동일성 백분률을 갖는다고 결정함에 의해, 코로나 바이러스에 속하고 그것에 계통적으로 상응하는 것으로 동정가능한, 분리된 본질적으로 포유동물의 양성-센스 단일가닥 RNA 바이러스(EMCR-CoV)가 제공된다.

이 EMCR-코로나바이러스(EMCR-CoV)의 서열정보를 공급함에 의해, 본 발명은 특히 포유동물, 더욱 특별히는 이 바이러스에 감염된 인간에게서 질병, 특히 호흡기 질병(비정형 폐렴)의 진단, 예방 및/또는 치료에 적용될 진단 수단 및 방법, 예방 수단 및 방법 및 치료수단 및 방법을 제공한다. 바이러스학에서, 특정 바이러스 감염의 진단, 예방 및/또는 치료는 상기 감염에 의한 상기 특정 바이러스에 가장 특이적인 시약으로 실시되는 것이 가장 바람직하다. 이 경우, 이것은 EMCR-CoV 바이러스의 상기 진단, 예방 및/또는 치료가 EMCR-CoV 바이러스에 대해 가장 특이적인 시약으로 실시되는 것이 바람직하다는 의미이다. 그러나, 이것은 덜 특이적인 것의 가능성을 배제하는 것은 아니고, 충분히 교차-반응성인 시약이, 예를 들면, 그들은 쉽게 구할 수 있고 비슷한 과제에 충분히 대처할 수 있기 때문에 대신 사용될 수 있다.

본 발명은 예를 들면, 상기 샘플과 본 발명에 따른 EMCR-CoV 특이 핵산 또는 항체의 반응에 의해, 상기 동물의 샘플에서의 바이러스 분리물 또는 그들 성분의 존재를 확인하는 것을 포함하는, 동물, 특히 포유동물, 더욱 특별히는 인간의 EMCR-CoV 감염을 바이러스학적으로 진단하는 방법, 및 상기 샘플과 EMCR-CoV 바이러스-특이 단백질 분해성 분자 또는 그것의 단편 또는 본 발명에 따른 항원의 반응에 의해, 상기 포유동물의 샘플에서 EMCR-CoV 바이러스 또는 그것의 성분에 대해 특이적으로 배향된 항체의 존재를 확인하는 것을 포함하는 포유동물의 EMCR-CoV 감염을 혈청학적으로 진단하는 방법을 제공한다.

본 발명은 또한, EMCR-CoV 바이러스, EMCR-CoV 바이러스-특이 핵산, 단백질분해성 분자 또는 그것의 단편, 본 발명에 따른 항원 및/또는 항체를 포함하는 EMCR-CoV 감염을 진단하기 위한 진단키트, 및 바람직하기는 상기 EMCR-CoV 바이러스, EMCR-CoV 바이러스-특이 핵산, 단백질 분해성 분자 또는 그것의 단편, 항원 및/또는 항체를 검출하기 위한 수단을 제공하고, 상기 수단은 예를 들면 본 분야(적절한 진단 키트 포멧의 예는 IF, ELISA, 중화분석, RT-PCR 분석)에서 사용되는 형광단 또는 효소 검출 시스템과 같은 여기성 기를 포함한다. 아직 동정되지 않은 바이러스 성분 또는 핵산, 단백질 분해성 분자 또는 그것의 단편과 같은 그것의 합성 동족체가 ECR-CoV-바이러스-특이적으로 동정될 수 있는 가를 결정하기 위해, 상기 성분의 핵산 또는 아미노산 서열을, 예를 들면, 여기에 제공된 계통분석을 사용하여 제공된 EMCR-CoV 바이러스 서열 및 공지의 비-EMCR-CoV 바이러스 서열(인간 코로나바이러스 299E가 사용되는 것이 바람직하다)과 비교한 서열 상동성에 의해 적어도 10, 바람직하기는 적어도 25, 더욱 바람직하기는 적어도 40 뉴클레오티드 또는 아미노산의 스트레치에 대해 분석하는 것으로 충분하다.

상기 EMCR-CoV 또는 비 EMCR-CoV 바이러스 서열과의 관계 정도에 따라, 성분 또는 합성 동족체가 동정될 수 있다.

그러므로, 본 발명은 신규한 병인성 약제, 코로나바이러스 과(family)에 속하는 분리된 필수적으로 포유동물 양성-센스 단일가닥 RNA 바이러스(이하 EMCR-CoV 바이러스라 명명), 및 EMCR-CoV 바이러스-특이 성분 또는 그들의 합성 동족체의 뉴클레오티드 서열을 제공한다.

코로나바이러스는 처음 1937년 닭으로부터 분리되었고, 처음 인간 코로나바이러스는 1965년 Tyrell과 Bonoe에 의해 인 비트로 증식되었다. 현재 이 과에는 약 13종이 있고, 이것은 소, 돼지, 설치류, 고양이, 개, 새 그리고 인간을 감염시킨다. 코로나바이러스 입자는 불규칙한 형태이고, 직경이 약 60~220nm이고, 외부 외피는 구별되는, '곤봉-형' 페플로머(peplomers; 길이 약 20nm 및 먼 말단에서의 폭 10nm)이다. '크라운-형' 외관은 과에 그 이름을 제공한다. 외피는 두개의 당단백질을 운반한다:S 세포 융합에 포함되고 주요 항원인 스파이크 당단백질 및 M, 막 당단백질, 이것은 출아와 외피 형성에 포함된다. 게놈은 염기성 N으로 명명된 인단백질에 결합되어 있다. 코로나바이러스의 게놈, 단일 가닥 양성-센스 RNA 가닥은 통상적으로 27~31Kb의 길이이고 5'메틸화 캡과 3' 폴리-A 테일을 함유하고, 그것에 의해 감염된 세포에서 mRNA로서 직접적으로 작용할 수 있다. 초기에, 5'ORF 1(약 20 Kb)는 바이러스성 폴리머라제를 생산하도록 번역되고, 이것은 이후 완전길이 음성 센스 가닥을 생산한다. 이것은 전사의 '네스티드 셋'과 같은 mRNA를 생산하기 위한 주형으로 사용되고, 72 뉴클레오티드의 동일한 5' 비-번역 리더서열 및 부합하는 3' 폴리아데닐화 말단을 갖는다. 이와 같이 생성된 각각의 mRNA는 단일시스트론성이고 5'말단에서 유전자는 가장 긴 mRNA 등으로부터 번역된다. 이들 독특한 세포질 구조물은 접합에 의해 생성되지 않고 전사 중의 폴리머라제에 의해 생산된다. 각 유전자 사이에 반복적인 유전자간 서열- AACUAAAC -이 있고, 이것은 각 ORF의 초기 위에 리더 서열을 접합하기 위한 전사효소 플러스 세포질 인자와 상호작용한다. 몇몇 코로나바이러스에서, 상기 단백질, 그러나 또한 적혈구응집소 에스테라제(HE) 및 여러 다른 비-구조적 단백질을 암호화하는 약 8개의 ORF가 있다.

새롭게 분리된 바이러스는 본 발명자들의 원형 EMCR-CoV 바이러스와 충분히 유사한 유전자 순서 및/또는 아미노산 서열 및/또는 핵산 서열을 포함할 때, 계통적으로 그리고 따라서 분류학상으로 EMCR-CoV에 상응하다. 지금까지 동일한 과의 다른 어느 바이러스와 EMCR-CoV 바이러스의 PRF 사이의 최고의 아미노산 서열 동일성은 인간 코로나바이러스 299E 또는 돼지 유행성 설사 바이러스이다(도 3 및 4 참조). 인간 코로나바이러스 229E와의 아미노산 동일성은 45%(핵단백질)에서 81%(RNA 합성효소 1b)의 범위이고; 흥미롭기는 RNA 합성효소 1a는 RNA 합성효소 1b의 81%와 반대로 단지 56%의 동일성을 갖는다. EMCR-CoV는 PEDV의 매트릭스 ORF에 약간 더 가까운 관계인 매트릭스를 제외하고, 모든 추정되는 ORF에서 지금까지 알려진 어느 다른 동일한 과의 바이러스보다 인간 코로나바이러스 229E와 더욱 밀접한 동일성을 갖는다. 각각 이들 언급된 최대값보다 더 높은 동질성을 갖는 개별적인 단백질 또는 전체 바이러스 분리물은 계통적으로 그리고 따라서 분류학상으로 EMCR-CoV 바이러스에 상응한다고 생각되며, 일반적으로 도 1에 나타낸 바와 같은 서열에 구조적으로 상응하는 핵산서열에 의해 암호화될 것이다. 이와 함께 본 발명은 도 1에 나타낸 서열의 분리된 바이러스에 계통적으로 상응하는 바이러스를 제공한다.

다른 바이러스들과 마찬가지로, 다른 근원에서 분리된 EMCR-CoV-바이러스들 간에 어느 정도의 변이가 발견될 수 있다는 것을 예상할 수 있음을 명심해야 한다.

또한, EMCR-CoV 바이러스의 바이러스 서열 또는 본 명세서에 제공된 분리된 EMCR-CoV 바이러스 유전자는 예를 들면, 유전자은행에서 발견되는 바와 같이(예를 들면, 수탁번호 af304460(HCoV-299E) 또는 af353511(PEDV)) 인간 코로나바이러스 299E 또는 돼지 유행성 설사 바이러스의 뉴클레오티드 또는 아미노산 서열과 비교하여, 예를 들면 95% 미만, 바람직하기는 90%미만, 더욱 바람직하기는 80% 미만, 더욱 바람직하기는 70% 미만 그리고 가장 바람직하기는 65% 미만의 뉴클레오티드 서열 동질성을 나타내거나 또는 95% 미만, 바람직하기는 90%미만, 더욱 바람직하기는 80% 미만, 더욱 바람직하기는 70% 미만 및 가장 바람직하기는 65% 미만의 아미노산 서열 동질성을 나타낸다.

대충 EMCR-CoV 균주의 서열 차이는 다른 코로나바이러스로 유추하여, 다소 높을 수 있다.

본 명세서에서 사용되는 용어 "뉴클레오티드 서열 동질성"은 두개의 (폴리)뉴클레오티드 사이의 동질성의 존재를 말하는 것이다. 폴리뉴클레오티드는, 두개의 서열에서 뉴클레오티드의 서열이 최대 일치를 위해 정렬될 때 동일하다면 "동질적인" 서열을 갖는다. 두개 이상의 폴리뉴클레오티드 간의 서열 비교는 일반적으로 서열 유사성의 국소적 영역을 동정하고 비교하기 위해 비교창에 걸쳐 두개의 서열의 일부를 비교함으로써 실행된다. 50, 60, 70, 80, 90, 95, 98, 99 또는 100% 서열 동질성과 같은, 폴리뉴클레오티드의 "서열 동질성 백분률"은 비교창에 걸쳐 두개의 최적으로 배열된 서열을 비교함으로써 결정되고, 여기서 비교창에서의 폴리뉴클레오티드 서열의 일부는 서열의 최적 배열을 위해 참조서열(추가 또는 결실을 포함하지 않는)과의 비교에 따라 추가 또는 결실(즉, 갭)을 포함할 수 있다. 백분률은:(a)매치된 위치의 수를 얻기 위해 두 서열에서 동일한 핵산 염기가 있는 위치의 수를 측정하고; (b) 매치된 위치의 수를 비교창에서의 위치의 총수로 나누고; (c) 결과에 100을 곱하여 서열 동질성의 백분률을 구하는 것으로 산출된다. 비교를 위한 서열의 최적 배열은 알려진 알고리즘의 컴퓨터화 처리에 의해 또는 검사에 의해 수행된다. 쉽게 이용가능한 서열 비교 및 복수개의 서열 배열 알고리즘은 각각 기본 국소배열 연구방법(Basic Local Alignment Search Tool)(Altschul, S.F. et al. 1990.J.Mol.Biol. 215:403; Altschul, S.F. et al.1997. Nucleic Acid Res. 25:3389-3402) 및 ClustalW 프로그램으로 둘 다 인터넷에서 이용가능하다. 다른 적절한 프로그램은 위스콘신 유전학 소프트웨어 패키지(Genetics Computer Group(GCG), Madison, WI, USA)의 GAP, BESTFIT 및 FASTA을 포함한다.

본 명세서에서 사용되는 바에 따르면, "실질적으로 상보적인"은 두개의 핵산서열이 서로에 대해 적어도 약 65%, 바람직하기는 약 70%, 더욱 바람직하기는 약 80%, 더욱 바람직하기는 90%, 가장 바람직하기는 약 98% 서열 상보성을 갖는 것을 의미한다. 이것은 프라이머와 프로브가 엄격한 조건하에 혼성화되기 위해 그들의 주형과 표적 핵산에 대해 각각 충분히 상보적이어야 한다는 의미이다. 그러므로, 본 명세서에 기재된 바와 같은 프라이머 서열은 주형 상의 결합 영역의 정확한 서열을 반영할 필요가 없고 변성 프라이머가 사용될 수 있다. 실질적으로 상보적인 프라이머 서열은 프라이머 결합 및 제2-가닥 합성을 갖도록 증폭 주형에 충분한 서열 상보성을 갖는 것이다.

용어 "혼성화"는 이중-가닥 핵산분자 또는 상보적 뉴클레오티드 사이의 수소결합에 의해 형성된 듀플렉스를 말한다. 용어 "교배하다" 또는 "어닐링"은 그 과정에 의해 핵산서열의 단일 가닥이 상보적 뉴클레오티드 사이의 수소결합을 통해 이중-나선 단편을 형성하는 과정을 말한다.

용어 "올리고뉴클레오티드"는 인 결합(예를 들면, 포스포디에스테르, 알킬 및 아릴-포스페이트, 포스포로티로에이트) 또는 비-인 결합(예를 들면, 펩티드, 술파메이트 및 기타)에 의해 연결된 뉴클레오티드 모노머들의 짧은 서열(보통 6~100 뉴클레오디드)을 언급한다. 올리고뉴클레오티드는 변형된 염기(예를 들면, 5-메틸 시토신) 및 변형된 당 기(예를 들면, 2'-O-메틸리보실, 2'-O-메톡시에틸 리보실, 2'-플루오로 리보실, 2'-아미노 리보실 등)를 갖는 변형된 뉴클레오티드를 포함할 수 있다. 올리고뉴클레오티드는 천연적으로 발생한 또는 합성의, 환형, 분지형 또는 선형의 및 임의로 안정한 2차 구조(예를 들면, 줄기-및-루프 그리고 루프-줄기-루프 구조)를 형성할 수 있는 도메인을 포함하는 단일-가닥 DNA 및 이중- 및 단일-가닥 RNA일 수 있다.

여기서 사용되는 용어 "프라이머"는, 핵산 가닥에 상보적인 프라이머 연장 생성물의 합성이 유도되는 환경에 놓이면, 즉 DNA 폴리머라제와 같은 폴리머반응을 위한 뉴클레오티드와 약제의 존재 및 적당한 온도 및 pH에서, DNA 폴리머가 접촉되도록 하고 그것에 의해 DNA 합성의 개시점으로 작용하는 증폭 표적에 어닐링할 수 있는 올리고뉴클레오티드를 말한다. (증폭) 프라이머는 증폭에서의 최대 효율을 위해 바람직하기는 단일 가닥이다. 바람직하기는, 프라이머는 올리고데옥시 리보뉴클레오티드이다. 프라이머는 중합반응을 위한 약제의 존재하에 연장 생성물의 합성을 준비하기에 충분히 길어야 한다. 프라이머의 정확한 길이는, 온도와 프라이머 근원을 포함하여, 여러 인자에 의존한다. 본 명세서에 사용되는 바와 같은 "이-방향성 프라이머의 쌍"은 PCR 증폭과 같은 DNA 증폭 분야에 일반적으로 사용되는 바와 같은, 하나는 정방향이고 다른 하나는 역방향인 프라이머를 말한다.

용어 "프로브"는 표적 핵산 서열 분석물 또는 그것의 cDNA 유도체에서 상보적 서열을 갖는 수소-결합된 듀플렉스를 인식하고 형성하는 단일-가닥 올리고뉴클레오티드 서열을 말한다.

용어 "스트린전트" 또는 "스트린전트 혼성화조건"은 예를 들면, 온도, 염농도, pH, 포름아미드 농도 등과 같은 혼성화의 안정성에 영향을 미치는 혼성화 조건을 말한다. 이들 조건은 경험적으로 프라이머 또는 프로브의 그것의 표적 핵산서열에 대한 특이결합을 최대화하고 비-특이 결합을 최소화하도록 최적화된다. 사용되는 바에 따라 용어는 프로브 또는 프라이머가 그것의 표적 서열에 다른 서열보다 검출가능하게(예를 들면, 적어도 기준보다 2배) 큰 정도로 혼성화되는 조건을 참조를 포함한다. 스트린전트 조건은 서열 의존이고 다른 환경에서 다를 것이다. 서열이 길수록 더 높은 온도에서 특이적으로 혼성화된다. 일반적으로, 스트린전트 조건은 정해진 이온강도 및 pH에서 특정 서열에 대한 열 용융점(Tm)보다 약 5℃ 낮도록 선택된다. Tm은 상보적 표적 서열의 50%가 바람직하기는 매치된 프로브 또는 프라이머에 혼성화되는 온도(정해진 이온강도 및 pH에서)이다.

통상적으로, 스트린전트 조건은 염 농도가 pH 7.0~8.3에서 Na+ 이온 약 1.0M 미만, 통상적으로 Na+ 이온 농도 (또는 다른 염) 약 0.01~1.0M이고 짧은 프로브 또는 프라이머(예를 들면 10~50 뉴클레오티드)의 경우 온도가 적어도 약 30℃이고 긴 프로브 또는 프라이머(예를 들면, 50 뉴클레오티드 초과)의 경우 온도가 적어도 약 60℃인 조건이다. 스트린전트 조건은 또한 포름아미드와 같은 탈안정화제의 첨가에 의해 달성될 수 있다. 예시적으로 낮은 스트린전트 조건 또는 "감소된 스트린전트 조건"은 37℃에서 30% 포름아미드, 1M NaCl, 1% SDS의 완충용액으로의 혼성화 및 40℃에서 2x SSC로의 세척을 포함한다. 예시적으로 높은 스트린전트 조건은 37℃에서 50% 포름아미드, 1M NaCl, 1% SDS에서의 혼성화 및 60℃에서 0.1x SSC로의 세척을 포함한다. 혼성화과정은 본 분야에 잘 알려져 있고 예를 들면, Ausubel et al, Current Protocols in Molecular Biology, John Wiley & Sons Inc., 1994에 기재되어 있다.

용어 "항체"는 항체의 항원 결합 형태에 대한 참조를 포함한다(예를 들면, Fab, F(ab)2). 용어 "항체"는 주로 면역글로불린 유전자 또는 면역글로불린 유전자들 또는 분석물에 특이적으로 결합하고 인식하는 그들의 단편에 의해 실질적으로 암호화되는 펩티드를 말한다. 그러나, 여러 다양한 항체 단편들이 불활성 항체의 소화의 의미로 정의되는 반면, 당업자는 이와 같은 단편들이 화학적으로 또는 재조합 DNA 방법론을 이용하여 합성될 수 있다는 것을 이해할 것이다. 그러므로, 여기서 사용되는 바에 따르면, 용어 항체는 또한 단일 사슬 Fv, 키메릭 항체(즉, 다양한 종의 일정 및 가변영역을 포함하는), 인간화된 항체(즉, 비-인간 근원으로부터 상보적 결정 영역(CDR)을 포함하는) 및 헤테로컨쥬게이트 항체(예를 들면, 이특이성 항체)와 같은 항체 단편을 포함한다.

간단히 말하면, 본 발명은 코로나바이러스에 속하고 계통적으로 거기에 상응한다는 것을, 상기 바이러스의 게놈의 적당한 단편의 핵산서열을 결정하고 계통트리 분석에서 그것을 시험하고 이것이 PEDV(돼지 유행성 설사 바이러스), HCoV-229E(인간 코로나바이러스 229E, PRCoV(돼지 호흡기 코로나바이러스), TGEV(전염성 위장염 바이러스), CaCoV(개 코로나바이러스) 및 FeCoV(고양이 코로나바이러스)의 바이러스 분리물에 상응하는 것보다 도 1에 나타낸 바와 같은 서열을 갖는 바이러스 분리물에 더욱 밀접히 계통적으로 상응한다는 것을 확인함에 의해 확인할 수 있는 분리된 본질적으로 포유동물의 양성 센스 단일가닥 RNA 바이러스(EMCR-CoV)를 제공하며, 여기서 최대 가능성 트리는 100 부트스트랩(bootstraps)과 3 점블(jumbles)을 이용하여 생성된다.

이와 같은 계통트리 분석에 알맞는 각각의 핵산 게놈 단편들은 예를 들면, 도 1에 나타낸 바와 같은 매트릭스 단백질 또는 핵 캡시드 단백질을 암호화하는 단편으로, 도2a 또는 도2b에 나타낸 계통트리 분석을 가져온다. 이와 같은 계통트리 분석에 유용한 다른 적절한 핵산 단편은 예를 들면, 리플리카제 1a 및 1b, 스파이크, orf 4a 및 4b, 그리고 E를 암호화하는 단편이다.

계통트리 분석에 유용한 적절한 개방형해독틀(ORF)은 바이러스 리플리카제를 암호화하는 ORF를 포함한다(ORF 1a). 도 1의 아미노산을 포함하는 서열을 갖는 리플리카제와, 분석된 리플리카제의 적어도 60%, 바람직하기는 적어도 70%, 더욱 바람직하기는 적어도 80%, 더욱 바람직하기는 적어도 90%, 가장 바람직하기는 적어도 95%의 전체 아미노산 동일성이 발견되면, 분석된 바이러스 분리물은 본 발명에 따른 EMCR-CoV 바이러스 분리물을 포함한다.

계통적 분석에 유용한 적절한 개방형해독틀(ORD)은 바이러스 리플리카제를 암호화하는 ORF를 포함한다(ORF 1b). 도 1의 아미노산을 포함하는 서열을 갖는 리플리카제와, 분석된 리플리카제의 적어도 82%, 바람직하기는 적어도 90%, 가장 바람직하기는 적어도 95%의 전체 아미노산 동일성이 발견되면, 분석된 바이러스 분리물은 본 발명에 따른 EMCR-CoV 바이러스 분리물을 포함한다.

계통적 분석에 유용한 또 다른 적절한 개방형해독틀(PRF)은 ORF 암호화 핵 캡시드 단백질을 포함한다. 도 1의 서열 F를 포함하는 서열에 의해 암호화된 핵 캡시드 단백질과, 분석된 핵 캡시드 단백질의 적어도 50%, 바람직하기는 적어도 60%, 더욱 바람직하기는 적어도 70%, 더욱 바람직하기는 적어도 80%, 더욱 바람직하기는 적어도 90%, 가장 바람직하기는 적어도 95%의 전체 아미노산 동일성이 발견되면, 분석된 바이러스 분리물은 본 발명에 따른 EMCR-CoV 바이러스 분리물을 포함한다.

계통 분석에 유용한 또 다른 적절한 개방형해독틀(ORF)은 매트릭스 단백질을 암호화하는 ORP를 포함한다. 도 1의 서열 F(의 일부)를 포함하는 서열에 의해 암호화된 매트릭스 단백질과, 분석된 매트릭스 단백질의 적어도 60%, 더욱 바람직하기는 적어도 70%, 더욱 바람직하기는 적어도 80%, 더욱 바람직하기는 적어도 90%, 가장 바람직하기는 적어도 95%의 전체 아미노산 동일성이 발견되면, 분석된 바이러스 분리물은 본 발명에 따른 EMCR-CoV 분리물을 포함한다.

계통 분석에 유용한 또 다른 적절한 개방형해독틀(ORF)은 스파이크 단백질 S를 암호화하는 ORF를 포함한다. 도 1에 나타낸 바와 같은 S 단백질의 E서열의 번역 2와 F 서열의 번역 1의 서열을 포함하는 서열에 의해 암호화된 분석된 S-단백질의 적어도 60%, 더욱 바람직하기는 적어도 70%, 더욱 바람직하기는 적어도 80%, 더욱 바람직하기는 적어도 90%, 가장 바람직하기는 적어도 95%의 전체 아미노산 동질성이 발견되면, 분석된 바이러스 분리물은 본 발명에 따른 EMCR-CoV 바이러스 분리물을 포함한다. EMCR-CoV 바이러스의 S ORF는(바이러스 복제물에 대해 암호화하는) PRF 1 주변에 위치하는 것으로 보이며, 이것은 S 단백질과 바이러스 폴리머라제 사이에 소위 2a유전자 및 HE-유전자를 갖는다.

본 발명은 다른 것 중에서 본 발명에 따른 바이러스로부터 얻을 수 있는 분리된 또는 재조합 핵산 또는 그들의 바이러스 특이 작용성 단편을 제공한다. 분리된 또는 재조합 핵산은 도 1에 주어진 바와 같은 서열 또는 스트린전트 조건하에서 이들과 혼성화될 수 있는 동족체의 서열을 포함한다. 특히, 본 발명은 EMCR-CoV 바이러스 핵산을 동정하기에 알맞는 프라이머 및/또는 프로브를 제공한다.

더우기, 본 발명은 본 발명에 따른 핵산을 포함하는 벡터를 제공한다. 무엇보다도 먼저, EMCR-CoV 바이러스의 게놈(의 일부)을 함유하는 플라즈미드 벡터와 같은 벡터, EMCR-CoV의 게놈(의 일부)을 함유하는 바이러스 벡터(예를 들면, 우두 바이러스, 레트로바이러스, 바쿨로바이러스, 그러나 이것으로 제한되는 것은 아님) 또는 다른 바이러스 또는 다른 병원체의 게놈(의 일부)을 함유하는 EMCR-CoV 바이러스가 제공된다.

또한, 본 발명은 본 발명에 따른 핵산 또는 벡터를 포함하는 숙주세포를 제공한다. EMCR-CoV 바이러스의 리플리카제 성분을 함유하는 플라즈미드 또는 바이러스 벡터는 관련 세포 타입(세균, 곤충세포, 진핵세포)에서 성분들의 발현을 위해 원핵세포에서 발생된다. EMCR-CoV 바이러스 게놈의 전장의 또는 부분적인 사본을 함유하는 플라즈마 또는 바이러스 벡터는 인비트로 또는 인비보 바이러스 핵산의 발현을 위해 원핵 세포에서 발생될 것이다. 후자의 벡터는 키메릭 바이러스 또는 키메릭 바이러스 단백질의 발생을 위한 다른 바이러스 서열을 함유할 수 있고, 복제 결함 바이러스의 발생을 위한 바이러스 게놈의 일부가 부족할 수 있고, 그리고 감독된 바이러스의 생성을 위한 돌연변이, 결실 또는 삽입물을 함유할 수 있다.

(야생형, 감독된, 복제-부족 또는 키메릭) EMCR-CoV 바이러스의 감염성 사본들이 상기의 최첨단 기술에 따른 폴리머라제 성분의 공동-발현 후 생성될 수 있다.

추가로, 진핵세포, 일시적으로 또는 안정하게 발현하는 하나 이상의 전장 또는 부분 EMCR-CoV 바이러스 단백질이 사용될 수 있다. 이와 같은 세포는 트란스펙션(단백질 또는 핵산 벡터), 감염(바이러스 벡터) 또는 형질도입(바이러스 벡터) 에 의해 제조될 수 있고 그리고 언급된 야생형, 감독된, 복제-부족 또는 키메릭 바이러스의 상보성에 유용할 것이다.

키메릭 바이러스는 2개 이상의 바이러스에 대해 보호하는 재조합 백신의 생산을 위해 특히 사용될 수 있다. 예를 들면, 인간 폐렴후 바이러스의 하나 이상의 단백질을 발현하는 EMCR-CoV 바이러스 벡터 또는 하나 이상의 EMCR-CoV 바이러스를 발현하는 인간 폐렴후 벡터는 두 바이러스 감염에 대한 이와 같은 벡터에 의해 백신화된 개개인을 보호할 것이다. 이와 같은 특이 키메릭 바이러스는 특히 본 발명에 유용한데, 이것이 예를 들면 인간 페렴후 바이러스의 공동-감염이 코로나바이러스 감염된 환자에게 흔히 일어나기 때문이다. 감독된 그리고 복제-부족 바이러스는 다른 바이러스에 대해 제안되어왔던 바와 같이 생백신으로 백신화 목적을 위해 사용될 수 있다.

바람직한 구현예에서, 본 발명은 단백질성 분자 또는 코로나바이러스-특이 바이러스 단백질 또는 본 발명에 따른 핵산으로 암호화된 그것의 기능적 단편을 제공한다. 유용한 단백질성 분자는 예를 들면, 본 발명에 따른 바이러스로부터 유래될 수 있는 유전자 또는 게놈의 단편의 어느 형태로부터 유래될 수 있다. 본 명세서에 제공된 바와 같이, 이와 같은 분자 또는 그들의 항원성 단편은 예를 들면, 진단방법 또는 키트 및 서브-유니트 백신 및 억제제 펩티드와 같은 약제학적 조성물에 유용하다. 특히 유용한 것은 바이러스 복제 단백질, 스파이크 단백질, 매트릭스 단백질, 핵 캡시드 또는 항원 또는 서브유니트 면역원성과 같은 그것의 항원성 단편이지만, 불활성화된 전체 바이러스가 또한 사용될 수 있다. 또한, 특히 유용한 것은 계통적 분석을 위해 동정된 재조합 핵산 단편에 의해 암호화된 단백질성 물질이고, 물론 바람직하기는 인비보(예를 들면 보호목적 또는 진단성 항제의 제공을 위해) 또는 인비트로(예를 들면, 파아지 디스플레이 기술 또는 합성 항체를 생성하는데 유용한 또 다른 기술)에서, EMCR-CoV 바이러스 특이 항체의 유도를 위한 계통적 분석에 유용한 ORF의 바람직한 범위 및 한계 내이다.

또한, 여기서 제공되는 것은, 천연 폴리클로날 또는 모노클로날인 항체 또는 본 발명에 따른 단백질성 분자 또는 EMCR-CoV 바이러스-특이 기능적 단편을 포함하는 항원과 특이적으로 반응하는 합성(예를 들면, (파아지)라이브러리-유래 결합분자)항체가 제공된다. 이와 같은 항체는 여기서 제공된 항체와 상기 바이러스 분리물 또는 그것의 단편의 반응을 포함하는 EMCR-CoV 바이러스와 같은 바이러스 분리물을 동정하는 방법에 유용하다. 이것은 정제된 또는 비-정제된 EMCR-CoV 바이러스 또는 ELISA, RIA, FACS 또는 항원 검출 분석의 유사한 포맷을 이용하는 그것의 일부(단백질, 펩티드)의 사용에 의해 달성될 수 있다. 선택적으로, 감염된 세포 또는 세포 배양물은 고전적인 면역형광법 또는 면역조직화학기술을 사용하여 바이러스 항체를 동정하는데 사용될 수 있다. 이와 관련하여 특히 유용한 것은 도 1에 기재된 서열의 하나 이상을 포함하는 뉴클레오티드 서열에 의해 암호화되는 EMCR-CoV 바이러스 단백질에 대해 발생하는 항체이다.

EMCR-CoV 바이러스로서 바이러스 분리물을 동정하기 위한 다른 방법은 상기 바이러스 분리물 또는 그것의 성분을 본 발명에 따른 바이러스 특이 핵산과 반응시키는 것을 포함한다.

이 방법으로, 본 발명은 독성학적으로 코로나바이러스과 내의 EMCR-CoV 바이러스 속에 속하는 것으로 동정가능한 양성-센스 단일 가닥 RNA 바이러스에 상응하는 포유동물 바이러스에 대하여 본 발명에 따른 방법으로 동정할 수 있는 바이러스 분리물을 제공한다.

본 방법은 포유동물의 EMCR-CoV 바이러스 감염을 바이러스학적으로 진단하는 방법에 유용하며, 상기 방법은 예를 들면 상기 포유동물의 샘플에서 바이러스 분리물 또는 그것의 분리물의 존재를 상기 샘플과 본 발명에 따른 핵산 또는 항체의 반응에 의해 결정하는 것을 포함한다.

본 발명의 방법은 폴리머라제 사슬반응(PCR; Mullis 1987, U.S. Pat.No. 4,683,195, 4,683,202 및 4,800,159)과 같은 어느 핵산 증폭방법에 의해 또는 리가제 사슬반응(LCR:Barany 1991, Proc. Natl. Acad.Sci.USA 88:189-193; EP Appl. No., 320,308), 자속성 서열복제(3SR; Guatlli et al., 1990, Proc.Natl. Acad.Sci.USA 87:1874-1878), 가닥 이동증폭(SDA; U.S.Pat Nos. 5,270,184, 및5,455,166), 전사증폭시스템(TAS; Kwoh et al., Proc. Natl. Acad. Sci. USA 86:1173-1177), Q-베타 리플리카제(Lizardi et al., 1988, Bio/Technology 6:1197), 회전순환증폭(RCQ; U.S.Pat No. 5,871,921), 핵산서열기재증폭(NASBA), 분열단편길이 다형성(U.S.Pat. No. 5,719,028), 핵산의 등온 및 키메릭 프라이머-개시 증폭(ICAN), 세분화-연장 증폭법(RAM;U.S.Pat Nos. 5,719,028 및 5,942,391) 또는 다른 적절한 핵산의 증폭법을 사용함에 의해 실시될 수 있다.

소수의 미스매치를 갖는 하나 이상의 증폭 프라이머로 핵산을 증폭하기 위해, 증폭반응은 감소된 스트린전트(38℃의 어닐링 온도를 사용한 PCR 증폭 또는 3.5mM MgCl₂의 존재)조건하에서 실시될 수 있다. 당업자는 적절한 스트린전트 조건을 선택할 수 있을 것이다.

본 명세서의 프라이머는 증폭되어질 각 특정 서열의 다른 가닥상에 존재하는 그들의 표적 영역에 "실질적으로" 보체(즉, 적어도 65%, 더욱 바람직하기는 적어도 80% 정확하게 보체)가 되도록 선택된다. 이오시톨 잔기 또는 모호한 염기들을 함유하는 프라이머 서열 또는 심지어 표적서열과 비교했을 때 하나 이상의 미스매치를 함유하는 프라이머를 사용하는 것이 가능하다. 일반적으로 표적 DNA 또는 RNA 올리고뉴클레오티드 서열과 적어도 65%, 더욱 바람직하기는 적어도 80% 동질성을 나타내는 서열이 본 발명의 방법에 사용하기에 알맞다고 생각된다. 서열 미스매치는 낮은 스트린전트 혼성화 조건에 사용될 때도 중요하지는 않다.

증폭산물의 검출은 기본적으로 공지의 방법으로 수행될 수 있다. 검출 단면은 직접적으로 방사성 라벨, 항체, 발광염료, 형광염료 또는 효소시약으로 염색되거나 라벨화될 수 있다. 직접 DNA 균주는 예를 들면, 아크리딘 오렌지, 에티디움 모노아지드 또는 호에타스트(Hoechst) 염료와 같은 삽입 염료를 포함할 수 있다.

선택적으로, DNA 또는 RNA 단편은 라벨된 dNTP 염기의 합성 단편에의 병합에 의해 검출될 수 있다. 뉴클레오티드 염기와 결합될 수 있는 검출 라벨은 예를 들면, 플루오레세인, 시아닌 염료 또는 BrdUrd를 포함한다.

프로브-기재 검출시스템을 사용할 때, 본 발명에 사용하기에 적절한 검출방법은 예를 들면, 효소 면역조사(EIA) 포맷(Jacobs et al., 1997, J.Clin.Microbiol. 35, 791-795)을 포함한다. EIA 방법에 의해 검출을 시행하기 위해, 증폭반응에 사용되는 정 또는 역 프라이머 모두 표적 DNA-앰플리콘의 다음의 EIA 검출을 위한 예를 들면 스트렙타비딘 코팅된 미세역가 플레이트웰 상에 표적 PCR 앰플리콘의 면역화를 위한 비오틴기와 같은 포획기를 포함할 수 있다(이하 참조). 당업자는 EIA 포맷에서 표적 DNA PCR 앰플리콘의 고정화를 위해 다른 기들도 사용될 수 있다는 것을 이해할 것이다.

본 명세서에 기재된 바와 같이 표적 DNA의 검출에 유용한 프로브는 바람직하기는 DNA 증폭과정에 의해 증폭됨에 따라 DNA 서열 영역의 적어도 일부에만 결합한다. 당업자는 본 명세서에 설명된 바와 같이 불필요한 실험없이 표적 DNA의 뉴클레오티드 서열을 기재로 한 검출에 알맞는 프로브를 제조할 수 있다. 또한 상보적 뉴클레오티드 서열, DNA 또는 RNA 또는 표적 DNA의 화학적으로 합성된 동족체는, 이와 같은 상보적 가닥이 적용된 증폭반응에서 증폭되는 한, 본 발명의 방법에서 타입-특이 검출 프로브로서 사용하기에 알맞다.

여기서 사용하기 위한 알맞는 검출방법은 예를 들면 앰플리콘(amplicon)의 고정화 및 그것의 DNA 서열의 프로브, 예를 들면 서던 블롯팅을 포함한다. 다른 포맷들은 상기와 같은 EIA 포맷을 포함할 수 있다. 결합의 검출이 용이하도록, 특정 앰플리콘 검출 프로브는 형광단, 발색단, 효소 또는 방사선-라벨과 같은 라벨 모이어티를 포함할 수 있고, 따라서 증폭반응의 반응산물에 대한 프로브의 결합을 용이하게 모니터할 수 있다. 이와 같은 라벨은 당업자들에게 잘 알려져 있고, 예를 들면, 플루오레세인 이소티오시아네이트(FITC), β-갈락토시다제, 호스라디쉬 페옥시다제, 스트렙타비딘, 비오틴, 디그옥시게닌, 35S 또는 125I를 포함한다. 다른 예들은 당업자들에게 분명할 것이다.

검출은 또한 예를 들면 Van den Brule et al.(2002, J.Clin.Microbiol. 40, 779-787)에 의해 기재된 바와 같은 소위 역라인 블롯(RLB) 분석에 의해서도 실시될 수 있다. 이 목적을 위해, RLB 프로브는 바람직하기는 예를 들면 카르복실-코팅된 나일론 막 강의 이후의 고정화를 위해 5' 아미노기로 합성된다. RLB 포맷의 이점은 시스템의 용이성과 그 속도이며, 따라서 원료처리량 샘플 처리를 허용하는 것이다.

RNA 또는 DNA 단편의 검출을 위한 핵산 프로브의 사용은 본 분야에 잘 알려져 있다. 최근 이들 방법은 표적 핵산의 프로브와의 혼성화 및 후-혼성화 세척을 포함한다. 특이성은 통상적으로 후-혼성화 세척, 이온강도인 임계 인자 및 최종 세척용액의 온도의 함수이다. 핵산 혼성화의 경우, Tm은 Meinkoth 및 Wahl, Anal. Biochem., 138:267-284(1984)의 식으로부터 어림잡혀지고: Tm=81.5℃+16.6(log M)+0.41(%GC)-0.61(% form)-500/L; 여기서 M은 일가 양이온의 모이어티이고, %GC는 핵산 중 구아노신과 뉴클레오티드의 백분률이고 및 % form은 혼성용액 중 포름아미드의 백분률이고, 그리고 L은 염기쌍 중 혼성물의 길이이다. Tm은 각 1%의 미스매칭에 대해 약 1℃까지 감소된다; 그러므로, 혼성화 및/또는 세척 조건은 원하는 동일성의 서열에 대해 혼성화되도록 조절될 수 있다. 예를 들면, >90% 동일성을 갖는서열이 약 5℃가 되도록 선택된다면, Tm은 10℃ 감소될 수 있다. 일반적으로, 스트린전트 조건은 정해진 이온강도 및 pH에서 특정 서열과 그것의 보체에 대한 열적 녹는점(Tm)보다 약 5℃ 낮도록 선택된다. 그러나, 심각한 스트린전트 조건은 녹는점(Tm) 보다 1,2,3, 또는 4℃ 낮은 온도에서 혼성화 및/또는 세척을 이용할 수 있고; 중간의 스트린전트 조건은 녹는점(Tm)보다 약 6,7,8,9, 또는 10℃ 낮은 온도에서 혼성화 또는 세척을 이용할 수 있고; 낮은 스트린전트 조건은 녹는점(Tm)보다 약 11, 12, 13, 14, 15 또는 20℃ 낮은 온도에서 혼성화 또는 세척을 이용할 수 있다. 식, 혼성화 및 세척 조성물, 및 원하는 Tm을 이용하여, 당업자는 혼성화 및/또는 세척 조건의 스트린전트가 변화는 본질적으로 기재된다는 것을 이해할 것이다. 미스매칭의 원하는 정도가 45℃(수용액) 또는 32℃(포름아미드 용액)보다 낮은 Tm을 가져온다면, 더 높은 온도가 사용될 수 있도록 SSC 농도를 증가시키는 것이 바람직하다. 핵산의 혼성화에 대한 광범위한 가이드가 Tijssen, Laboratory Techniques in Biochemistm and Molecular Biology-Hybridization with Nucleic Acid Probes, Part I, chapter 2" Overview of principles of hybridization and the strategy of nucleaic acid probe assays" Elsevier. New York(1993); 및 Current Protocols in Milecular Biology, Chapter 2, Ausubel, et al., Eds., Greene Publishing and Wiley-Interscience, New York (1995)에서 발견된다.

다른 면에서, 본 발명은 표적 RNA 또는 DNA의 일반적인 검출을 위한 올리고뉴클레오티드 프로브를 제공한다. 여기서 검출 프로브는 본 발명의 증폭 반응에 의해 생성된 이중가닥 핵산 중 한 가닥에 "실질적으로" 상보적이도록 선택된다. 바람직하기는 프로브는 예를 들면 비오틴 라벨된 표적 RNA 또는 DNA로부터 생성된 앰플리콘의 안티센스 가닥의 고정화를 위한 실질적인 보체이다.

그들의 표적 서열에 대한 하나 이상의 미스매치를 함유하기 위한 본 발명의 프로브를 검출하는 것이 허용된다. 일반적으로, 표적 올리고뉴클레오티드 서열과 적어도 65%, 더욱 바람직하기는 적어도 80%의 동일성을 나타내는 서열이 본 발명의 방법에 사용하기에 알맞다고 간주된다.

항체, 모노클로날 및 폴리클로날 모두는 본 발명의 검출목적을 위해, 예를 들면, 액체상 중에 사용되거나 고체상 캐리어 상에 결합할 수 있는 면역조사에서 사용될 수 있다. 또한, 면역조사에서 모노클로날 항체는 여러 방법으로 검출가능하게 라벨될 수 있다. 면역조사 포맷의 다양성은 특정 단백질(또는 다른 분석체)와 특이적으로 반응하는 항체를 고르기 위해 사용될 수 있다. 예를 들면, 고체-상 ELISA 면역조사는 단백질과 특이적으로 면역반응하는 모노클로날 항체를 선택하는데 일상적으로 사용된다. 선택적 결합을 결정하는데 사용될 수 있는 면역조사 포맷과 조건의 기술에 관하여 Harlow and Lane, Antibodies, A Laboratiry Manual, Cold Spring Harbor Publications, New York(1988)을 참조하라. 본 발명의 항체를 이용할 수 있는 면역조사 타입의 예는 직접 또는 간접 포맷에서 경쟁 및 비-경쟁 면역조사이다. 이와 같은 면역조사의 예는 방사성면역조사(RIA) 및 샌드위치(면역매트릭)분석이다. 본 발명의 항체를 사용하는 항원의 검출은 생리적 샘플 상의 면역세포화학 분석을 포함하여, 정, 역 또는 동시 모드로 작동하는 면역조사를 이용하여 실시될 수 있다. 당업자들은 불필요한 실험없이 다른 면역조사를 알거나 또는 쉽게 인식할 수 있을 것이다.

항체는 여러 다양한 캐리어에 결합될 수 있고 표적 분자의 존재를 검출하는데 사용될 수 있다. 잘 알려진 캐리어의 예는 유리, 폴리스티렌, 폴리프로필렌, 폴리에틸렌, 덱스트린, 나일론, 아밀라제, 천연 및 변형 셀룰로스, 폴리아크릴아미드, 아가로스 및 마그네타이트를 포함한다. 캐리어의 특성은 본 발명의 목적을 위해 가용성 또는 불용성일 수 있다. 당업자는 모노클로날 항체에 결합하기 위한 다른 알맞는 캐리어를 알거나 또는 반복적인 실험을 사용하여 인식할 수 있을 것이다.

본 발명은 또한, 샘플과 단백질성 분자 또는 그것의 단편 또는 본 발명의 항원과의 반응에 의해 상기 포유동물의 샘플에서 EMCR-CoV 바이러스 또는 그것의 성분에 대해 특이적으로 지향된 항체의 존재를 검출하는 것을 포함하는 포유동물의 EMCR-CoV 바이러스 감염을 혈청학적으로 진단하는 방법을 제공한다.

여기에 제공된 방법 및 수단은 특히 바이러스학적 또는 혈청학적 진단에 의해, EMCR-CoV 바이러스 감염을 진단하기 위한 진단키트에 유용하다. 이와 같은 키트 또는 조사는 예를 들면, 본 발명에 따른 바이러스, 핵산, 단백질성 분자 또는 그것의 단편, 항원 및/또는 항체를 포함할 수 있다.

예를 들면, 특히 인간에게서, EMCR-CoV 바이러스 감염의 치료 또는 예방 및/또는 비정형 폐렴의 치료 또는 예방을 위한 약제학적 조성물의 생산을 위한 본 발명에 따른 바이러스, 핵산, 단백질성 분자 또는 그것의 단편, 항원 및/또는 항체의 용도가 또한 제공된다. 바람직하기는 도1의 관련 번역에 나타낸 바와 같이 스파이크 단백질의 아미노산 서열의 일부를 함유하는 펩티드가 치료 또는 예방 펩티드의 제조를 위해 사용된다. 또한, 바람직하기는 도1의 관련 번역에 기재된 바와 같이 스파이크 단백질의 아미노산 서열을 포함하는 단백질이 서브-유니트 백신의 제조에 사용된다. 더우기, 도1의 번역에 나타낸 바와 같이 코로나바이러스의 핵 캡시드는 코로나바이러스에 대한 세포-중재 면역을 이끌어내는데 특히 유용하며 서브-유니트 백신의 제조에 사용될 수 있다.

바이러스의 감독은 이 목적을 위해 개발된 확립된 방법에 의해 달성될 수 있고, 다른 종의 관련 바이러스, 실험실 동물 및/또는 배양물의 조직/세포를 통한 일련의 계대접종, 37℃ 이하의 온도(냉각-적응)에서 세포 배양물을 통한 일련의 계대접종, 분자 클론의 부위지향 돌연변이생성 및 관련 바이러스간의 유전자 또는 유전자 단편의 교환의 사용이 포함되지만 이것으로 제한되는 것은 아니다.

본 발명에 따른 바이러스, 핵산, 단백질성 분자 또는 그것의 단편, 항원 및/또는 항체를 포함하는 약제학적 조성물은 예를 들면, 본 발명에 따른 약제학적 조성물을 개인에게 제공하는 것을 포함하는 EMCR-CoV 바이러스 감염 및/또는 호흡기 질병의 치료 및 예방을 위한 방법에 사용될 수 있다. 이것은 상기 개인이 인간일 때 가장 유용하다. EMCR-CoV 바이러스 단백질에 대한, 특히 EMCR-CoV 바이러스의 스파이크 단백질에 대한, 바람직하기는 도 1의 번역에 나타낸 바와 같은 아미노산 서열에 대한 항체들은 수동 백신과 같이, 예방 또는 치료 목적을 위해서도 역시 유용하다. 다른 코로나바이러스로부터, 스파이크 단백질이 매우 강한 항원이고 스파이크 항원에 대한 항체가 예방 및 치료 백신에 사용될 수 있다는 것이 알려져 있다.

본 발명은 또한 본 발명에 따른 바이러스를 포함하는 세포 배양물 또는 실험 동물을 확립하고, 상기 배양물 또는 동물을 후보 항바이러스 약제로 치료하고, 그리고 상기 바이러스 또는 상기 배양물 또는 동물의 감염에 대한 상기 약제의 효과를 결정하는 것을 포함하는 비정형 폐렴의 치료에 유용한 방법을 제공한다. 이와 같은 항바이러스 약제의 예는 EMCR-CoV 바이러스-중화 항체, 또는 그것의 기능적 단편을 포함하지만, 다른 특성의 항바이러스 약제가 또한 얻어진다.

본 발명은 또한 약제학적 조성물의 제조를 위한, 특히 특별히는 EMCR-CoV 바이러스 감염에 의해 발생된 비정형 폐렴의 치료를 위한 약제학적 조성물의 제조를 위한 본 발명에 따른 항바이러스 약제의 용도를 제공하고, 그리고 EMCR-CoV 바이러스 감염 또는 비정형 페렴의 치료 및 예방을 위한 방법에 유용한, 본 발명에 따른 항바이러스 약제를 포함하는 약제학적 조성물을 제공하고, 상기 방법은 개개인에게 이와 같은 약제학적 조성물을 제공하는 것을 포함한다.

본 발명은 또한 예방 및/또는 치료적 방법 및/또는 제제의 시험에 유용한 동물 모델을 포함한다. 이것은 유인원이 EMCR-CoV 바이러스에 감염될 수 있고, 그것에 의해 임상적 증상, 더욱 중요하기는 EMCR-CoV 바이러스에 의한 비정형 폐렴을 앓는 인간에게 발견되는 것과 유사한 조직 형태학을 나타낼 수 있다고 가정한다. 바이러스로 감염되기 전 또는 감염 중 예방적 또는 치료적 처리를 받는 유인원은 인간 환자에서의 예방 또는 치료와 같은 적용에 양호하고 유용한 예상적 가치를 가질 것이다.

본 발명은 추가로 실시예에서 설명되지만, 이것으로 제한되는 것은 아니다.

도 1은 EMCR-CoV 바이러스의 일부의 뉴클레오티드 서열이다. 또한 폴리펩티드의 추정 아미노산 서열을 포함한다.

도 2는 분리된 EMCR-CoV의 뉴클레오티드 서열과 그것과 유전적으로 가장 밀접한 관련물과의 계통적 관계이다. 계통트리는 100 부트스트랩과 3 점블을 이용한 최대 가능성 분석에 의해 발생되었다. 핵산 교환의 수를 나타내는 단위를 각 계통트리에 나타내었다. 도 1a는 매트릭스 유전자 뉴클레오티드 서열의 최대 가능수(tree)이다. 트리에서의 숫자는 부트스트랩 값을 나타낸다. 스케일 바는 대략적으로 관련 서열들 간의 10% 뉴클레오티드 차이를 반영한다. 도 1b는 핵 캡시드 유전자 뉴클레오티드 서열의 최대 가능수이다. 트리에서의 숫자는 부트스트랩 값을 나타낸다. 스케일 바는 대략적으로 관련 서열들 간의 10% 뉴클레오티드 차이를 반영한다.

도 3은 추정된 리플리카제 1a 리플리카제 1b, 리플리카제 1ab, 스파이크, Orf E, 매트릭스 및 핵 캡시드 단백질(각각 3a-g)에 대한 그리고 EMCR-CoV 바이러스와 밀접히 관련된 코로나바이러스 사이의 추정 매트릭스 단백질과 뉴클레오단백질(각각 3h 및 3i)에 대한 아미노산 동정을 나타내는 유사성 매트릭스이다. 약자에 대해서는 내용을 참조.

도 4는 여러 코로나바이러스의 배열을 나타낸다. 5' 비번역 영역 게놈성 서열(a); 추정 orf 1a 아미노산 서열(b); 추정 orf 1b 아미노산 서열(c); 추정 orf 1ab 아미노산 서열(d); 추정 스파이크 아미노산 서열(e); 추정 orf 4a 아미노산 서열(f); 추정 orf 4ab 아미노산 서열(g); 추정 orf E 아미노산 서열(h); 추정 매트릭스 아미노산 서열(i); 추정 핵단백질 아미노산 서열(j); 추정 3' 비번역 게놈성 서열(k); 약자에 대해서는 내용을 참조.

실시예

시편 수집

코 솜을 사용하여 폐렴을 앓는 8월령 환자로부터 바이러스를 수집하였다.

바이러스 분리 및 배양

목 솜을 tMK 세포의 배양물에 깊이 담그고 4시간 동안 계대배양하였다. 바이러스는 그리고 나서 Vero-119 세포에 있었다. 세포 배양 상등물을 함유하는 바이러스 1역가를 수확하고, 바이러스를 초원심분리기에서 펠렛화하고 바이러스 펠렛을 PBS 1㎖중에 재현탁하였다.

RNA 분리

RNA를 감염된 세포 배양물의 상등액 또는 슈크로스 기울기 분획으로부터 제조자의 지침에 따라 고순도 RNA 분리 키트(Roche Diagnostics, Almere, the Netherlands)를 사용하여 분리하였다.

서열화

정제된 RNA를 서열화를 위해 BaseClear Hoding BV(Leiden, The netherlands)로 보냈다.

계통적 분석

BioEdit 버전 5.0.9.에서 작동하는 뉴클레오티드 서열을 Clustal W를 사용하여 배열하였다. 최대 가능수를 100 부트스트랩과 3 점블을 이용한 Phylip 5.6 Seqboot 와 DNA-Ml 패키지를 사용하여 생성하였다. 컨센서스 트리를 Phylip 5.6의 컨센서스 패키지를 사용하여 계산하였다. 이들 컨센서스 트리를 원 서열로부터 가지 길이를 재산출하기 위한 DAN-ML에서 사용자 트리로 사용하였다.

EMCR-CoV의 서열을 4개의 코로나바이러스 군에서 각 종들을 나타내는 참조 바이러스의 서열과 비교하였다. 이들은: 인간 코로나바이러스 229E(229E), af304460; 돼지 유행성 설사 바이러스(PEDV) af353511; 전염성 개스트로엔테리티스 바이러스(TGEV), aj271965; 송아지 코로나바이러스(BoCoV), af22029; 뮤린 간염 바이러스(MHV), af201929; 새 감염성 기관지염 바이러스(AIBV), m95169, 개 코로나바이러스(CaCoV), d13096; 고양이 코로나바이러스(FeCoV) ay204704; 돼지 호흡기 코로나바이러스(PRCoV), z24675; 인간 코로나바이러스 OC43(OC43), m76373, l14643, m933990; 돼지 적혈구응집 뇌척수염 바이러스(HEV), ay078417; 래트 코로나바이러스(RtCoV) af 207551). 바이러스들에 대한 참조는 NCBI 카탈로그의 넘버이다(http://www.ncbi.nlm.nih.gov/entrez/).

일반적으로, EMCR-CoV와 같은 코로나바이러스는 다음 프로토콜에 따라 분리 되고 동정될 수 있다.

시편 수집

바이러스 분리물을 찾기 위해 인간, 육식동물(개, 고양이, 족제비, 바다표범 등), 말, 반추동물(소, 양, 염소 등), 돼지, 토끼, 새(가금류, 타조 등)과 같은 포유동물로부터 비인두 흡입물, 목과 코의 솜, 기관지 폐포 세척, 혈청 및 플라즈마 샘플, 및 대변을 조사해야만 한다. 새 배설강으로부터 약솜과 배설물도 조사될 수 있다. 혈청은 ELISA과 같은 면역학적 분석, RT-PCR과 같은 분자-기초 분석 및 중화분석으로 수집되어야 한다.

수집된 바이러스 시편들은 5㎖ 둘베코 MEM 배지(BioWhittaker, Walkersville, MD)로 희석되고 1분 동안 와동 혼합기에서 완전히 혼합될 수 있다. 현택물은 10분 동안 840xg에서 원심분리된다. 침전물을 면역형광기술을 위해 멀티스팟 슬라이드 상에 펴바르고 상등액은 바이러스 분리를 위한 것이다.

바이러스 분리

바이러스 분리를 위해 Vero-118 세포 또는 tMK 세포(RIVM, Bilthoven, The Netherlands)를, 태아 소 혈청 10%로 보충된 하기의 배지(BioWhittaker, Vervier, Belgium)를 갖는 유리 슬라이드를 함유하는 24 웰 플레이트(Costar, Cambridge, UK)에서 배양하였다. 인큐베이션 전에 플레이트를 PBS로 세척하고 NaHCO₃ 0.52/ℓg, 0.025M Hepes(Biowhittaker), 2mM L-글루타민(BioWhittlker), 페니실린 200 유니트/ℓ, Hepes 0.025 M(Biowhittaker), 락트알부민 1g/ℓ(Sigma-Aldrich, Zwijndrecht, The Netherlands), D-글루코스 2.0 g/ℓ(Merck, Amsterdam, The Netherlands), 펩톤 10g/ℓ(Oxoid, Haarlem, The Netherlands) 및 트립신 0.02%(Life Tecnologies, Bethesda, MD)이 보충된 행크스염(ICN, Costa mesa, CA)를 갖는 이글스 MEM을 공급하였다. 플레이트를 환자 샘플의 상등액으로 웰당 0.2㎖ 로 삼중으로 접종하고, 이어서 1시간 동안 840x g에서 원심분리하였다. 인큐베이션 후, 플레이트를 37℃에서 1~7일 동안 배양하고, 배양물을 CPE에 대해 매일 확인하였다. 연장된 CPE는 일반적으로 5~10 내로 관찰되었고 단층의 세포 분리를 포함하였다.

바이러스 배양

상기와 같이 매질 중의 tMK 세포 또는 베로 클론 118 세포의 서브-합류 단일층을 CPE를 나타내는 샘플의 상등액 또는 환자로부터 취한 샘플로 배양하였다.

RNA 분리

RNA를 감염된 세포 배양물의 상등액 또는 슈크로스 기울기 분획으로부터 제조자의 지침에 따라 고순도 RNA 분리 키트(Roche Diagnostics, Almere, the Netherlands)를 사용하여 분리하였다. RNA는 또한 분야에 잘 알려진 다른 공정에 의해 분리될 수 있다(Current Protocols in Molecular Biology).

서열 분석

서열 분석을 BaseClear Hoding BV(Leiden, The Netherlands)에 의해 실시하였다.

SEQUENCE LISTING <110> ViroNovative B.V. <120> Novel atypical pneumonia-causing virus <130> P67119KR00 <150> EP 03078613.1 <151> 2003-11-18 <150> EP 04808721.7 <151> 2004-11-18 <150> PCT/NL2004/000805 <151> 2004-11-18 <160> 97 <170> PatentIn version 3.3 <210> 1 <211> 27530 <212> DNA <213> EMCR Coronavirus <220> <221> CDS <222> (265)..(12432) <223> Replicase 1a <220> <221> CDS <222> (20435)..(24502) <223> Spike protein <220> <221> CDS <222> (25163)..(25396) <223> E protein <220> <221> CDS <222> (25405)..(26085) <223> M protein <220> <221> CDS <222> (26096)..(27229) <223> E protein <400> 1 agatagagaa ttttcttatt tagactttgt gtctactcct ctcaactaaa cgaaattttt 60 ctagtgctgt catttgttat ggcagtccta gtgtaattga aatttcgtca agtttgtaaa 120 ctggttaggc aagtgttgta ttttctgtgt ttaagcactg gtggttctgt ccactagtgc 180 acacattgat acttaagtgg tgttctgtca ctgcttattg tggaagcaac gttctgtcgt 240 tgtggaaacc aataactgct aacc atg ttt tac aat caa gtg aca ctt gct 291 Met Phe Tyr Asn Gln Val Thr Leu Ala 1 5 gtt gca agt gat tcg gaa att tca ggt ttt ggt ttt gcc att cct tct 339 Val Ala Ser Asp Ser Glu Ile Ser Gly Phe Gly Phe Ala Ile Pro Ser 10 15 20 25 gta gcc gtt cgc gct tat agc gaa gcc gct gca caa ggt ttt cag gca 387 Val Ala Val Arg Ala Tyr Ser Glu Ala Ala Ala Gln Gly Phe Gln Ala 30 35 40 tgc cgc ttt gtt gct ttt ggc tta cag gat tgt gta acc ggt att aat 435 Cys Arg Phe Val Ala Phe Gly Leu Gln Asp Cys Val Thr Gly Ile Asn 45 50 55 gat gac gat tat gtc att gca ttg act ggt act aat cag ctt tgt gcc 483 Asp Asp Asp Tyr Val Ile Ala Leu Thr Gly Thr Asn Gln Leu Cys Ala 60 65 70 aaa att tta ctt ttt tct gat aga cct ctt aat ttg cga ggt tgg ctc 531 Lys Ile Leu Leu Phe Ser Asp Arg Pro Leu Asn Leu Arg Gly Trp Leu 75 80 85 att ttt tct aac agc aat tat gtt ctt cag gac ttt gat gtt gtt ttt 579 Ile Phe Ser Asn Ser Asn Tyr Val Leu Gln Asp Phe Asp Val Val Phe 90 95 100 105 ggc cat ggt gca gga agt gtg gtt ttt gtg gat aag tat atg tgt ggt 627 Gly His Gly Ala Gly Ser Val Val Phe Val Asp Lys Tyr Met Cys Gly 110 115 120 ttt gat ggt aaa cct gtg tta cct aaa aac atg tgg gaa ttt aga gat 675 Phe Asp Gly Lys Pro Val Leu Pro Lys Asn Met Trp Glu Phe Arg Asp 125 130 135 tac ttt aat gat aat act gat agt att gtt att ggt ggt gtc act tat 723 Tyr Phe Asn Asp Asn Thr Asp Ser Ile Val Ile Gly Gly Val Thr Tyr 140 145 150 caa tta gca tgg gat gtt ata cgt aaa gac ctt tct tat gaa cag caa 771 Gln Leu Ala Trp Asp Val Ile Arg Lys Asp Leu Ser Tyr Glu Gln Gln 155 160 165 aat gtt tta gct att gag agc att cat tat ctt ggc act aca ggt cat 819 Asn Val Leu Ala Ile Glu Ser Ile His Tyr Leu Gly Thr Thr Gly His 170 175 180 185 act ttg aag tct ggt tgc aaa ctc att aat gcc aag ccg cct aaa tat 867 Thr Leu Lys Ser Gly Cys Lys Leu Ile Asn Ala Lys Pro Pro Lys Tyr 190 195 200 tct tct aag gtt gtt ttg agt ggt gaa tgg aat gct gtg tat aag gcg 915 Ser Ser Lys Val Val Leu Ser Gly Glu Trp Asn Ala Val Tyr Lys Ala 205 210 215 ttt ggt tca cca ttt att aca aat ggt ata tca ttg cta gat ata att 963 Phe Gly Ser Pro Phe Ile Thr Asn Gly Ile Ser Leu Leu Asp Ile Ile 220 225 230 gtt aaa cca gtt ttc ttt aat gct ttt gtt aaa tgc aat tgt ggt tct 1011 Val Lys Pro Val Phe Phe Asn Ala Phe Val Lys Cys Asn Cys Gly Ser 235 240 245 gag aat tgg agt gtt ggt gca tgg gat ggt tat cta tct tct tgt tgt 1059 Glu Asn Trp Ser Val Gly Ala Trp Asp Gly Tyr Leu Ser Ser Cys Cys 250 255 260 265 ggc aca cct gct aag aaa ctt tgt gtt gtt cct ggt aat gtt gtt cct 1107 Gly Thr Pro Ala Lys Lys Leu Cys Val Val Pro Gly Asn Val Val Pro 270 275 280 ggt gat gtg atc atc acc tca act gat gct ggt tgt ggt gtt aaa tac 1155 Gly Asp Val Ile Ile Thr Ser Thr Asp Ala Gly Cys Gly Val Lys Tyr 285 290 295 tat gct ggc tta gtt gtt aaa cat att act aac att act ggt gtg tct 1203 Tyr Ala Gly Leu Val Val Lys His Ile Thr Asn Ile Thr Gly Val Ser 300 305 310 tta tgg cgt gtt aca gct gtt cat tct gat gga atg ttt gtg gca aca 1251 Leu Trp Arg Val Thr Ala Val His Ser Asp Gly Met Phe Val Ala Thr 315 320 325 tct tct tat gat gca ctt ttg cat aga aat tca tta gac cct ttt tgc 1299 Ser Ser Tyr Asp Ala Leu Leu His Arg Asn Ser Leu Asp Pro Phe Cys 330 335 340 345 ttt gat gtt aac act tta ctt tct aat caa tta cgt cta gct ttt ctt 1347 Phe Asp Val Asn Thr Leu Leu Ser Asn Gln Leu Arg Leu Ala Phe Leu 350 355 360 ggt gct tct gtt aca gaa gat gtt aaa ttt gct gct agc act ggt gtt 1395 Gly Ala Ser Val Thr Glu Asp Val Lys Phe Ala Ala Ser Thr Gly Val 365 370 375 att gac att agt gct ggt atg ttt ggt ctt tac gat gac ata ttg aca 1443 Ile Asp Ile Ser Ala Gly Met Phe Gly Leu Tyr Asp Asp Ile Leu Thr 380 385 390 aac aat aaa cct tgg ttt gta cgc aaa gct tct ggg ctt ttt gat gca 1491 Asn Asn Lys Pro Trp Phe Val Arg Lys Ala Ser Gly Leu Phe Asp Ala 395 400 405 atc tgg gat gct ttt gtt gcc gct att aag ctt gtg cca act act act 1539 Ile Trp Asp Ala Phe Val Ala Ala Ile Lys Leu Val Pro Thr Thr Thr 410 415 420 425 ggt ggt ttg gtt agg ttt gtt aag tct atc gct tca act gtt tta act 1587 Gly Gly Leu Val Arg Phe Val Lys Ser Ile Ala Ser Thr Val Leu Thr 430 435 440 gtt tct aat ggt gtt att att atg tgt gca gat gtt cca gat gct ttt 1635 Val Ser Asn Gly Val Ile Ile Met Cys Ala Asp Val Pro Asp Ala Phe 445 450 455 caa cca gtt tac cgc aca ttt aca caa gct att tgt gct gca ttt gat 1683 Gln Pro Val Tyr Arg Thr Phe Thr Gln Ala Ile Cys Ala Ala Phe Asp 460 465 470 ttt tct tta gat gta ttt aaa att ggt gat gtt aaa ttt aaa cga ctt 1731 Phe Ser Leu Asp Val Phe Lys Ile Gly Asp Val Lys Phe Lys Arg Leu 475 480 485 ggt gat tat gtt ctt act gaa aat gct ctt gtt cgt ttg act act gaa 1779 Gly Asp Tyr Val Leu Thr Glu Asn Ala Leu Val Arg Leu Thr Thr Glu 490 495 500 505 gtt gtt cgt ggt gtt cgt gat gct cgc ata aag aaa gcc atg ttt act 1827 Val Val Arg Gly Val Arg Asp Ala Arg Ile Lys Lys Ala Met Phe Thr 510 515 520 aaa gta gtt gta ggt cct aca act gaa gtt aag ttt tct gtt att gaa 1875 Lys Val Val Val Gly Pro Thr Thr Glu Val Lys Phe Ser Val Ile Glu 525 530 535 ctt gcc act gtt aat ttg cgt ctt gtt gat tgt gca cct gta gtt tgc 1923 Leu Ala Thr Val Asn Leu Arg Leu Val Asp Cys Ala Pro Val Val Cys 540 545 550 cct aaa ggt aaa att gtt gtt att gct gga caa gct ttt ttc tat agt 1971 Pro Lys Gly Lys Ile Val Val Ile Ala Gly Gln Ala Phe Phe Tyr Ser 555 560 565 ggt ggt ttt tat cgt ttt atg gtt gat tct aca act gta tta aat gac 2019 Gly Gly Phe Tyr Arg Phe Met Val Asp Ser Thr Thr Val Leu Asn Asp 570 575 580 585 cct gtt ttt act ggt gag tta ttt tat act att aag ttt agt ggt ttt 2067 Pro Val Phe Thr Gly Glu Leu Phe Tyr Thr Ile Lys Phe Ser Gly Phe 590 595 600 aag ctt gat ggt ttt aac cat cag ttt gtt aat gct agt tct gct aca 2115 Lys Leu Asp Gly Phe Asn His Gln Phe Val Asn Ala Ser Ser Ala Thr 605 610 615 gat gcc att att gct gtt gag ctg ttg tta tcg gat ttt aaa act gca 2163 Asp Ala Ile Ile Ala Val Glu Leu Leu Leu Ser Asp Phe Lys Thr Ala 620 625 630 gtt ttt gtg tac aca tgt gtg gtt gat ggt tgt agt gtc att gtt aga 2211 Val Phe Val Tyr Thr Cys Val Val Asp Gly Cys Ser Val Ile Val Arg 635 640 645 cgt gat gct aca ttc gcc aca cat gtg tgt ttt aag gac tgt tat agt 2259 Arg Asp Ala Thr Phe Ala Thr His Val Cys Phe Lys Asp Cys Tyr Ser 650 655 660 665 att tgg gag caa ttc tgc att gat aat tgt ggt gag cca tgg ttt ttg 2307 Ile Trp Glu Gln Phe Cys Ile Asp Asn Cys Gly Glu Pro Trp Phe Leu 670 675 680 act gat tat aat gct atc ttg cag agt aat aac cct caa tgt gct att 2355 Thr Asp Tyr Asn Ala Ile Leu Gln Ser Asn Asn Pro Gln Cys Ala Ile 685 690 695 gtt caa gca tcg gag tct aaa gtt ttg ctt gag agg ttt tta cct aag 2403 Val Gln Ala Ser Glu Ser Lys Val Leu Leu Glu Arg Phe Leu Pro Lys 700 705 710 tgt cct gaa ata ctg ttg agt att gat gat ggc cat tta tgg aat ctt 2451 Cys Pro Glu Ile Leu Leu Ser Ile Asp Asp Gly His Leu Trp Asn Leu 715 720 725 ttt gtt gaa aag ttt aat ttt gtt aca gat tgg tta aaa act ctt aag 2499 Phe Val Glu Lys Phe Asn Phe Val Thr Asp Trp Leu Lys Thr Leu Lys 730 735 740 745 ctt aca ctt act tct aat ggt ctt tta ggt aat tgt gcc aaa cgt ttt 2547 Leu Thr Leu Thr Ser Asn Gly Leu Leu Gly Asn Cys Ala Lys Arg Phe 750 755 760 aga cgt gtt ttg gta aaa ttg ctt gat gtc tat aat ggt ttt ctt gaa 2595 Arg Arg Val Leu Val Lys Leu Leu Asp Val Tyr Asn Gly Phe Leu Glu 765 770 775 act gtc tgt agt gtc gta cac act gct ggt gtt tgc att aaa tat tat 2643 Thr Val Cys Ser Val Val His Thr Ala Gly Val Cys Ile Lys Tyr Tyr 780 785 790 gct gtt aat gtt cca tat gta gtt att agt ggt ttt gta agt cgt gta 2691 Ala Val Asn Val Pro Tyr Val Val Ile Ser Gly Phe Val Ser Arg Val 795 800 805 att cgt aga gaa agg tgt gac gtg act ttt cct tgt gtt agt tgt gtc 2739 Ile Arg Arg Glu Arg Cys Asp Val Thr Phe Pro Cys Val Ser Cys Val 810 815 820 825 act ttt ttc tat gaa ttt tta gac acg tgt ttt ggt gtt agt aaa cct 2787 Thr Phe Phe Tyr Glu Phe Leu Asp Thr Cys Phe Gly Val Ser Lys Pro 830 835 840 aat gcc att gat gtt gaa cat tta gag ctt aaa gaa act gtt ttt gtt 2835 Asn Ala Ile Asp Val Glu His Leu Glu Leu Lys Glu Thr Val Phe Val 845 850 855 gaa cct aag gat ggt ggt caa ttt ttt gtt tct gat gat tat ctt tgg 2883 Glu Pro Lys Asp Gly Gly Gln Phe Phe Val Ser Asp Asp Tyr Leu Trp 860 865 870 tat gtt gta gat gac att tat tat cca gct tca tgt aat ggt gta ttg 2931 Tyr Val Val Asp Asp Ile Tyr Tyr Pro Ala Ser Cys Asn Gly Val Leu 875 880 885 cca gtt gct ttt aca aaa ttg gca ggt ggt aaa ata tct ttt tct gat 2979 Pro Val Ala Phe Thr Lys Leu Ala Gly Gly Lys Ile Ser Phe Ser Asp 890 895 900 905 gat gtt ata gtt cat gat gtt gaa cct acc cat aaa gtc aag ctc ata 3027 Asp Val Ile Val His Asp Val Glu Pro Thr His Lys Val Lys Leu Ile 910 915 920 ttt gag ttt gaa gat gat gtt gtt acc agt ctt tgt aag aag agt ttt 3075 Phe Glu Phe Glu Asp Asp Val Val Thr Ser Leu Cys Lys Lys Ser Phe 925 930 935 ggt aag tct att att tat aca ggt gat tgg gaa ggt tta cat gaa gtt 3123 Gly Lys Ser Ile Ile Tyr Thr Gly Asp Trp Glu Gly Leu His Glu Val 940 945 950 ctt aca tct gca atg aat gtc att ggg caa cat att aag ttg cca caa 3171 Leu Thr Ser Ala Met Asn Val Ile Gly Gln His Ile Lys Leu Pro Gln 955 960 965 ttt tat att tat gat gaa gag ggt ggt tat gat gtt tct aaa cca gtt 3219 Phe Tyr Ile Tyr Asp Glu Glu Gly Gly Tyr Asp Val Ser Lys Pro Val 970 975 980 985 atg att tca caa tgg cct att agt gat gat agt gat ggt tgt gtt gtt 3267 Met Ile Ser Gln Trp Pro Ile Ser Asp Asp Ser Asp Gly Cys Val Val 990 995 1000 gaa gcg agc act gat ttt cat caa tta gaa tct gtt aga gaa gag 3312 Glu Ala Ser Thr Asp Phe His Gln Leu Glu Ser Val Arg Glu Glu 1005 1010 1015 gtt gat ata att gaa caa cct ttt ggg gaa gtt gaa cat gcg ctc 3357 Val Asp Ile Ile Glu Gln Pro Phe Gly Glu Val Glu His Ala Leu 1020 1025 1030 tca att aga caa cct ttt tct ttt tct ttt aga gat gaa ttg ggt 3402 Ser Ile Arg Gln Pro Phe Ser Phe Ser Phe Arg Asp Glu Leu Gly 1035 1040 1045 gtt cgt gtt tta gat caa tct gat aat aat tgt tgg att agt acc 3447 Val Arg Val Leu Asp Gln Ser Asp Asn Asn Cys Trp Ile Ser Thr 1050 1055 1060 aca ctt ata cag ttg caa ctt aca aag ctt ttg gat gat tct att 3492 Thr Leu Ile Gln Leu Gln Leu Thr Lys Leu Leu Asp Asp Ser Ile 1065 1070 1075 gag atg caa ttg ttt aaa gtt ggt aaa gtt gat tca att gtt caa 3537 Glu Met Gln Leu Phe Lys Val Gly Lys Val Asp Ser Ile Val Gln 1080 1085 1090 aag tgt tat gag ttg tct cat tta att agt ggt tca ctt ggt gat 3582 Lys Cys Tyr Glu Leu Ser His Leu Ile Ser Gly Ser Leu Gly Asp 1095 1100 1105 agt ggt aaa ctt ctt agt gaa ctt ctt aaa gat aaa tat aca tgt 3627 Ser Gly Lys Leu Leu Ser Glu Leu Leu Lys Asp Lys Tyr Thr Cys 1110 1115 1120 tct ata act ttt gag atg tct tgt gat tgt ggt aaa aag ttt gat 3672 Ser Ile Thr Phe Glu Met Ser Cys Asp Cys Gly Lys Lys Phe Asp 1125 1130 1135 gag caa gtt ggt tgt ttg ttt tgg att atg cct tac aca aaa ctt 3717 Glu Gln Val Gly Cys Leu Phe Trp Ile Met Pro Tyr Thr Lys Leu 1140 1145 1150 ttt caa aaa ggt gag tgt tgt att tgt cat aaa atg cag act tat 3762 Phe Gln Lys Gly Glu Cys Cys Ile Cys His Lys Met Gln Thr Tyr 1155 1160 1165 aag ctt gtt agt atg aaa ggt act ggt gtg ttt gta cag gat cca 3807 Lys Leu Val Ser Met Lys Gly Thr Gly Val Phe Val Gln Asp Pro 1170 1175 1180 gca cct att gac att gat gct ttc cct gtt aga cct ata tgt tca 3852 Ala Pro Ile Asp Ile Asp Ala Phe Pro Val Arg Pro Ile Cys Ser 1185 1190 1195 tct gta tat tta ggt gtt aag ggt tct ggt cat tat caa aca aat 3897 Ser Val Tyr Leu Gly Val Lys Gly Ser Gly His Tyr Gln Thr Asn 1200 1205 1210 tta tac agt ttt gac aaa gct att gat ggt ttt ggt gtc ttt gac 3942 Leu Tyr Ser Phe Asp Lys Ala Ile Asp Gly Phe Gly Val Phe Asp 1215 1220 1225 att aaa aat agt agt gtt aat act gtt tgt ttt gtt gat gtt gat 3987 Ile Lys Asn Ser Ser Val Asn Thr Val Cys Phe Val Asp Val Asp 1230 1235 1240 ttt cat agt gta gaa ata gaa gct ggt gaa gtt aaa cct ttt gct 4032 Phe His Ser Val Glu Ile Glu Ala Gly Glu Val Lys Pro Phe Ala 1245 1250 1255 gta tat aaa aat gtt aaa ttt tat tta ggt gat att tca cac ctt 4077 Val Tyr Lys Asn Val Lys Phe Tyr Leu Gly Asp Ile Ser His Leu 1260 1265 1270 gta aac tgt gtt tct ttt gac ttt gtt gtc aat gct gct aat gaa 4122 Val Asn Cys Val Ser Phe Asp Phe Val Val Asn Ala Ala Asn Glu 1275 1280 1285 aat ctc atg cat gga ggc ggt gtc gca cgt gct att gat att ttg 4167 Asn Leu Met His Gly Gly Gly Val Ala Arg Ala Ile Asp Ile Leu 1290 1295 1300 act gaa ggt caa ctt cag tca tta tct aaa gat tac att agt agt 4212 Thr Glu Gly Gln Leu Gln Ser Leu Ser Lys Asp Tyr Ile Ser Ser 1305 1310 1315 aat ggt cca ctt aag gtt gga gca ggt gtt atg ttg gag tgt gaa 4257 Asn Gly Pro Leu Lys Val Gly Ala Gly Val Met Leu Glu Cys Glu 1320 1325 1330 aaa ttc aat gta ttt aat gtt gtt ggt ccg cga act ggt aaa cat 4302 Lys Phe Asn Val Phe Asn Val Val Gly Pro Arg Thr Gly Lys His 1335 1340 1345 gag cat tca tta ctt gtt gaa gct tat aat tct att tta ttt gaa 4347 Glu His Ser Leu Leu Val Glu Ala Tyr Asn Ser Ile Leu Phe Glu 1350 1355 1360 aat ggt att cca ctt atg cct ctt ctt agt tgt ggt att ttt ggt 4392 Asn Gly Ile Pro Leu Met Pro Leu Leu Ser Cys Gly Ile Phe Gly 1365 1370 1375 gta agg att gaa aat tct ctt aaa gct ttg ttt agt tgt gac att 4437 Val Arg Ile Glu Asn Ser Leu Lys Ala Leu Phe Ser Cys Asp Ile 1380 1385 1390 aat aaa cca ttg caa gtt ttt gtt tat tct tca aat gaa gaa caa 4482 Asn Lys Pro Leu Gln Val Phe Val Tyr Ser Ser Asn Glu Glu Gln 1395 1400 1405 gct gtt ctt aag ttt tta gat ggt tta gat tta aca cca gtc att 4527 Ala Val Leu Lys Phe Leu Asp Gly Leu Asp Leu Thr Pro Val Ile 1410 1415 1420 gac gat gtt gat gtt gtt aaa cct ttt aga gtt gaa ggt aat ttt 4572 Asp Asp Val Asp Val Val Lys Pro Phe Arg Val Glu Gly Asn Phe 1425 1430 1435 tca ttc ttt gat tgt ggt gtc aat gcc ttg gat ggt gat att tac 4617 Ser Phe Phe Asp Cys Gly Val Asn Ala Leu Asp Gly Asp Ile Tyr 1440 1445 1450 tta tta ttt act aac tct att tta atg ttg gat aaa caa gga caa 4662 Leu Leu Phe Thr Asn Ser Ile Leu Met Leu Asp Lys Gln Gly Gln 1455 1460 1465 tta ttg gac aca aaa ctt aat ggt att ttg caa cag gca gtt ctt 4707 Leu Leu Asp Thr Lys Leu Asn Gly Ile Leu Gln Gln Ala Val Leu 1470 1475 1480 gat tat ctt gct aca gtt aaa act gta cca gct ggt aat ttg gtt 4752 Asp Tyr Leu Ala Thr Val Lys Thr Val Pro Ala Gly Asn Leu Val 1485 1490 1495 aaa ctt gtt gtt gag agt tgt acc att tat atg tgt gtt gta cca 4797 Lys Leu Val Val Glu Ser Cys Thr Ile Tyr Met Cys Val Val Pro 1500 1505 1510 tcg ata aat gat ctt tct ttt gat aaa aat ctt ggt cgt tgt gtg 4842 Ser Ile Asn Asp Leu Ser Phe Asp Lys Asn Leu Gly Arg Cys Val 1515 1520 1525 cgt aaa ctt aat aga ttg aaa act tgt gtt att gcc aat gtt cct 4887 Arg Lys Leu Asn Arg Leu Lys Thr Cys Val Ile Ala Asn Val Pro 1530 1535 1540 gct att gat gtt ttg aaa aag ctt ctt tca agt ttg act tta act 4932 Ala Ile Asp Val Leu Lys Lys Leu Leu Ser Ser Leu Thr Leu Thr 1545 1550 1555 gtt aaa ttt gtt gta gag agt aat gtt atg gat gtt aac gac tgt 4977 Val Lys Phe Val Val Glu Ser Asn Val Met Asp Val Asn Asp Cys 1560 1565 1570 ttt aag aat gat aat gta gtt ttg aaa att act gaa gat ggt att 5022 Phe Lys Asn Asp Asn Val Val Leu Lys Ile Thr Glu Asp Gly Ile 1575 1580 1585 aat gtt aaa gat gtt gtt gtt gag tct tct aag tca ctt ggt aaa 5067 Asn Val Lys Asp Val Val Val Glu Ser Ser Lys Ser Leu Gly Lys 1590 1595 1600 caa ttg ggt gtt gtg agt gat ggt gtt gac tct ttt gaa ggt gtt 5112 Gln Leu Gly Val Val Ser Asp Gly Val Asp Ser Phe Glu Gly Val 1605 1610 1615 tta cct att aat act gat act gtc tta tct gta gct cca gaa gtt 5157 Leu Pro Ile Asn Thr Asp Thr Val Leu Ser Val Ala Pro Glu Val 1620 1625 1630 gac tgg gtt gct ttt tac ggt ttt gaa aag gca gca ctt ttt gct 5202 Asp Trp Val Ala Phe Tyr Gly Phe Glu Lys Ala Ala Leu Phe Ala 1635 1640 1645 tct ttg gat gta aag cca tat ggt tac cct aat gat ttt gtt ggt 5247 Ser Leu Asp Val Lys Pro Tyr Gly Tyr Pro Asn Asp Phe Val Gly 1650 1655 1660 ggt ttt aga gtt ctt ggg acc acc gac aat aat tgt tgg gtt aat 5292 Gly Phe Arg Val Leu Gly Thr Thr Asp Asn Asn Cys Trp Val Asn 1665 1670 1675 gca act tgt ata att tta cag tat ctt aag cct act ttt aaa tct 5337 Ala Thr Cys Ile Ile Leu Gln Tyr Leu Lys Pro Thr Phe Lys Ser 1680 1685 1690 aag ggt tta aat gtt ctt tgg aac aaa ttt gtt aca ggt gat gtt 5382 Lys Gly Leu Asn Val Leu Trp Asn Lys Phe Val Thr Gly Asp Val 1695 1700 1705 gga cct ttt gtt agt ttt att tat ttt ata act atg tct tca aag 5427 Gly Pro Phe Val Ser Phe Ile Tyr Phe Ile Thr Met Ser Ser Lys 1710 1715 1720 ggt caa aag ggt gat gct gaa gag gca tta tct aaa ttg tca gag 5472 Gly Gln Lys Gly Asp Ala Glu Glu Ala Leu Ser Lys Leu Ser Glu 1725 1730 1735 tat ttg att agt gat tct att gtt act ctt gaa caa tat tca act 5517 Tyr Leu Ile Ser Asp Ser Ile Val Thr Leu Glu Gln Tyr Ser Thr 1740 1745 1750 tgt gac att tgt aaa agt act gta gtt gaa gtt aaa agt gct gtt 5562 Cys Asp Ile Cys Lys Ser Thr Val Val Glu Val Lys Ser Ala Val 1755 1760 1765 gtc tgt gct agt gtg ctt aaa gat ggt tgt gat gtt ggt ttt tgt 5607 Val Cys Ala Ser Val Leu Lys Asp Gly Cys Asp Val Gly Phe Cys 1770 1775 1780 cca cac aga cat aaa ttg cgt tca cgt gtt aag ttt gtt aat gga 5652 Pro His Arg His Lys Leu Arg Ser Arg Val Lys Phe Val Asn Gly 1785 1790 1795 cgt gtt gtt att acc aat gtt ggt gaa cct ata att tca caa cct 5697 Arg Val Val Ile Thr Asn Val Gly Glu Pro Ile Ile Ser Gln Pro 1800 1805 1810 tct aag ttg ctt aat ggt att gct tat aca aca ttt tca ggt tct 5742 Ser Lys Leu Leu Asn Gly Ile Ala Tyr Thr Thr Phe Ser Gly Ser 1815 1820 1825 ttt gat aac ggt cac tat gta gtt tat gat gct gct aat aat gct 5787 Phe Asp Asn Gly His Tyr Val Val Tyr Asp Ala Ala Asn Asn Ala 1830 1835 1840 gtc tat gat ggt gct cgt tta ttt gct tca gat ttg tct act tta 5832 Val Tyr Asp Gly Ala Arg Leu Phe Ala Ser Asp Leu Ser Thr Leu 1845 1850 1855 gct gtt aca gct att gtt gta gta ggt ggt tgt gta aca tct aat 5877 Ala Val Thr Ala Ile Val Val Val Gly Gly Cys Val Thr Ser Asn 1860 1865 1870 gtt cca cca att gtt agt gag aaa att tct gtt atg gat aaa ctt 5922 Val Pro Pro Ile Val Ser Glu Lys Ile Ser Val Met Asp Lys Leu 1875 1880 1885 gat act ggt gca caa aaa ttt ttc caa ttt ggt gat ttt gtt atg 5967 Asp Thr Gly Ala Gln Lys Phe Phe Gln Phe Gly Asp Phe Val Met 1890 1895 1900 aat aac att gtt ctg ttt tta act tgg ttg ctt agt atg ttt agt 6012 Asn Asn Ile Val Leu Phe Leu Thr Trp Leu Leu Ser Met Phe Ser 1905 1910 1915 ctt tta cgt act tct att atg aag cat gat att aaa gtt att gcc 6057 Leu Leu Arg Thr Ser Ile Met Lys His Asp Ile Lys Val Ile Ala 1920 1925 1930 aag gct cct aaa cgt aca ggt gtt att ttg aca cgt agt ttt aag 6102 Lys Ala Pro Lys Arg Thr Gly Val Ile Leu Thr Arg Ser Phe Lys 1935 1940 1945 tat aac att aga tct gct ttg ttt gtt gta aag cag aag tgg tgt 6147 Tyr Asn Ile Arg Ser Ala Leu Phe Val Val Lys Gln Lys Trp Cys 1950 1955 1960 gtt att gtt act ttg ttt aag ttc tta ttg tta tta tat gct att 6192 Val Ile Val Thr Leu Phe Lys Phe Leu Leu Leu Leu Tyr Ala Ile 1965 1970 1975 tat gca ctt gtt ttt atg att gtg caa ttt agt cct ttt aat agt 6237 Tyr Ala Leu Val Phe Met Ile Val Gln Phe Ser Pro Phe Asn Ser 1980 1985 1990 ctt tta tgt ggt gac att gta agt ggt tat gaa aaa tcc act ttt 6282 Leu Leu Cys Gly Asp Ile Val Ser Gly Tyr Glu Lys Ser Thr Phe 1995 2000 2005 aat aag gat att tat tgt ggt aat tct atg gtt tgt aag atg tgt 6327 Asn Lys Asp Ile Tyr Cys Gly Asn Ser Met Val Cys Lys Met Cys 2010 2015 2020 ttg ttt agt tat caa gag ttt aat gat ttg gat cat act agt ctt 6372 Leu Phe Ser Tyr Gln Glu Phe Asn Asp Leu Asp His Thr Ser Leu 2025 2030 2035 gtt tgg aag cac att cgt gat cct ata tta atc agt tta caa cca 6417 Val Trp Lys His Ile Arg Asp Pro Ile Leu Ile Ser Leu Gln Pro 2040 2045 2050 ttt gtt ata ctt gtt att ttg tta att ttt ggt aat atg tat ttg 6462 Phe Val Ile Leu Val Ile Leu Leu Ile Phe Gly Asn Met Tyr Leu 2055 2060 2065 cgt ttt gga ctt tta tat ttt gtt gca caa ttt att agt act ttt 6507 Arg Phe Gly Leu Leu Tyr Phe Val Ala Gln Phe Ile Ser Thr Phe 2070 2075 2080 ggt tct ttc tta ggc ttt cat cag aaa cag tgg ttt tta cat ttt 6552 Gly Ser Phe Leu Gly Phe His Gln Lys Gln Trp Phe Leu His Phe 2085 2090 2095 gtg ccg ttt gat gtt tta tgt aat gag ttt tta gct aca ttt att 6597 Val Pro Phe Asp Val Leu Cys Asn Glu Phe Leu Ala Thr Phe Ile 2100 2105 2110 gtc tgc aaa att gtt tta ttt gtt aga cat att att gtt ggc tgt 6642 Val Cys Lys Ile Val Leu Phe Val Arg His Ile Ile Val Gly Cys 2115 2120 2125 aat aat gct gac tgt gta gct tgt tct aaa agt gct aga ctt aaa 6687 Asn Asn Ala Asp Cys Val Ala Cys Ser Lys Ser Ala Arg Leu Lys 2130 2135 2140 cgt gta cca ctt caa act att att aat ggt atg cat aaa tca ttc 6732 Arg Val Pro Leu Gln Thr Ile Ile Asn Gly Met His Lys Ser Phe 2145 2150 2155 tat gtt aat gct aat ggt ggt act tgt ttc tgt aat aaa cat aac 6777 Tyr Val Asn Ala Asn Gly Gly Thr Cys Phe Cys Asn Lys His Asn 2160 2165 2170 ttc ttt tgt gtt aat tgt gat tct ttt ggg cct ggt aat act ttt 6822 Phe Phe Cys Val Asn Cys Asp Ser Phe Gly Pro Gly Asn Thr Phe 2175 2180 2185 att aat ggt gat att gca aga gag ctt ggt aat gtt gtt aaa aca 6867 Ile Asn Gly Asp Ile Ala Arg Glu Leu Gly Asn Val Val Lys Thr 2190 2195 2200 gct gtt caa ccc aca gct cct gca tat gtt att att gat aag gta 6912 Ala Val Gln Pro Thr Ala Pro Ala Tyr Val Ile Ile Asp Lys Val 2205 2210 2215 gat ttt gtt aat gga ttt tat cgt ctt tat agt ggt gac act ttt 6957 Asp Phe Val Asn Gly Phe Tyr Arg Leu Tyr Ser Gly Asp Thr Phe 2220 2225 2230 tgg cgg tat gac ttt gac att act gaa tct aag tat agt tgt aaa 7002 Trp Arg Tyr Asp Phe Asp Ile Thr Glu Ser Lys Tyr Ser Cys Lys 2235 2240 2245 gag gtt ctg aag aat tgt aat gtt tta gaa aat ttt att gtt tac 7047 Glu Val Leu Lys Asn Cys Asn Val Leu Glu Asn Phe Ile Val Tyr 2250 2255 2260 aat aat agt ggt agt aac att aca cag att aaa aat gct tgt gtt 7092 Asn Asn Ser Gly Ser Asn Ile Thr Gln Ile Lys Asn Ala Cys Val 2265 2270 2275 tat ttt tct caa ttg ttg tgt gaa cct ata aag ttg gta aat tca 7137 Tyr Phe Ser Gln Leu Leu Cys Glu Pro Ile Lys Leu Val Asn Ser 2280 2285 2290 gag ttg ttg tca act tta tca gtt gat ttt aat ggt gtt ttg cat 7182 Glu Leu Leu Ser Thr Leu Ser Val Asp Phe Asn Gly Val Leu His 2295 2300 2305 aag gca tat gtt gat gtt ttg tgt aat agt ttt ttt aag gag cta 7227 Lys Ala Tyr Val Asp Val Leu Cys Asn Ser Phe Phe Lys Glu Leu 2310 2315 2320 act gct aac atg tcc atg gct gaa tgt aaa gct aca ctt ggt ttg 7272 Thr Ala Asn Met Ser Met Ala Glu Cys Lys Ala Thr Leu Gly Leu 2325 2330 2335 act gtt tct gat gat gat ttt gtt tca gct gtt gcc aat gca cat 7317 Thr Val Ser Asp Asp Asp Phe Val Ser Ala Val Ala Asn Ala His 2340 2345 2350 agg tat gac gtt ttg ctt tca gat ttg tca ttt aat aat ttt ttt 7362 Arg Tyr Asp Val Leu Leu Ser Asp Leu Ser Phe Asn Asn Phe Phe 2355 2360 2365 att tct tat gct aaa cct gaa gat aag ttg tcc gtt tat gac att 7407 Ile Ser Tyr Ala Lys Pro Glu Asp Lys Leu Ser Val Tyr Asp Ile 2370 2375 2380 gct tgt tgt atg cgt gcc ggt tct aag gtt gtt aac cat aat gtt 7452 Ala Cys Cys Met Arg Ala Gly Ser Lys Val Val Asn His Asn Val 2385 2390 2395 tta atc aaa gag tca ata cct att gtt tgg ggt gtc aag gac ttt 7497 Leu Ile Lys Glu Ser Ile Pro Ile Val Trp Gly Val Lys Asp Phe 2400 2405 2410 aat act ctt tct caa gaa ggt aag aag tac ctt gtt aaa aca act 7542 Asn Thr Leu Ser Gln Glu Gly Lys Lys Tyr Leu Val Lys Thr Thr 2415 2420 2425 aaa gca aag ggt ttg act ttt tta tta act ttt aat gat aac caa 7587 Lys Ala Lys Gly Leu Thr Phe Leu Leu Thr Phe Asn Asp Asn Gln 2430 2435 2440 gca att aca caa gtt cct gct act agt ata gtt gca aaa cag ggt 7632 Ala Ile Thr Gln Val Pro Ala Thr Ser Ile Val Ala Lys Gln Gly 2445 2450 2455 gct ggt ttt aaa cgt act tat aat ttt ctg tgg tat gta tgt tta 7677 Ala Gly Phe Lys Arg Thr Tyr Asn Phe Leu Trp Tyr Val Cys Leu 2460 2465 2470 ttt gtt gtt gca ttg ttt att ggt gtc tca ttt att gat tat aca 7722 Phe Val Val Ala Leu Phe Ile Gly Val Ser Phe Ile Asp Tyr Thr 2475 2480 2485 acc act gta act agc ttt cat ggt tat gat ttt aag tac att gag 7767 Thr Thr Val Thr Ser Phe His Gly Tyr Asp Phe Lys Tyr Ile Glu 2490 2495 2500 aat ggt cag ttg aag gtg ttt gaa gca cct tta cac tgt gtt cgt 7812 Asn Gly Gln Leu Lys Val Phe Glu Ala Pro Leu His Cys Val Arg 2505 2510 2515 aat gtt ttt gat aat ttt aat caa tgg cat gag gct aag ttt ggt 7857 Asn Val Phe Asp Asn Phe Asn Gln Trp His Glu Ala Lys Phe Gly 2520 2525 2530 gtt gtt act act aat agt gat aaa tgt cct ata gtt gtt ggt gtt 7902 Val Val Thr Thr Asn Ser Asp Lys Cys Pro Ile Val Val Gly Val 2535 2540 2545 tca gag cgt att aat gtt gtt cct ggt gtt cca aca aat gta tat 7947 Ser Glu Arg Ile Asn Val Val Pro Gly Val Pro Thr Asn Val Tyr 2550 2555 2560 ttg gta gga aag act ctt gtt ttt aca tta cag gct gct ttt gga 7992 Leu Val Gly Lys Thr Leu Val Phe Thr Leu Gln Ala Ala Phe Gly 2565 2570 2575 aac aca ggt gtt tgt tat gac ttt gat ggt gtt acc act agt gat 8037 Asn Thr Gly Val Cys Tyr Asp Phe Asp Gly Val Thr Thr Ser Asp 2580 2585 2590 aag tgt att ttt aat tct gct tgt act agg ttg gaa ggt ttg ggt 8082 Lys Cys Ile Phe Asn Ser Ala Cys Thr Arg Leu Glu Gly Leu Gly 2595 2600 2605 ggt gac aat gtt tat tgt tac aac act gat ctt att gaa ggt tct 8127 Gly Asp Asn Val Tyr Cys Tyr Asn Thr Asp Leu Ile Glu Gly Ser 2610 2615 2620 aaa cct tat agt att tta cag ccc aat gct tat tat aag tat gat 8172 Lys Pro Tyr Ser Ile Leu Gln Pro Asn Ala Tyr Tyr Lys Tyr Asp 2625 2630 2635 gtt aaa aat tat gta cgt ttt cca gaa att tta gct aga ggt ttt 8217 Val Lys Asn Tyr Val Arg Phe Pro Glu Ile Leu Ala Arg Gly Phe 2640 2645 2650 ggc tta cgt act att aga act ttg gct aca cgt tat tgt aga gtt 8262 Gly Leu Arg Thr Ile Arg Thr Leu Ala Thr Arg Tyr Cys Arg Val 2655 2660 2665 ggt gaa tgc cgt gac tca cat aaa ggt gtt tgt ttt ggt ttt gat 8307 Gly Glu Cys Arg Asp Ser His Lys Gly Val Cys Phe Gly Phe Asp 2670 2675 2680 aaa tgg tat gtt aat gat gga cgt gtt gat gac ggt tac att tgt 8352 Lys Trp Tyr Val Asn Asp Gly Arg Val Asp Asp Gly Tyr Ile Cys 2685 2690 2695 ggt gat ggt ctt ata gac ctt ctt gtt aat gta ctc tca atc ttt 8397 Gly Asp Gly Leu Ile Asp Leu Leu Val Asn Val Leu Ser Ile Phe 2700 2705 2710 agt tca tct ttt agc gtt gtg gct atg tct gga cat atg ttg ttt 8442 Ser Ser Ser Phe Ser Val Val Ala Met Ser Gly His Met Leu Phe 2715 2720 2725 aat ttt ctt ttt gca gca ttt att aca ttt ttg tgc ttt tta gtt 8487 Asn Phe Leu Phe Ala Ala Phe Ile Thr Phe Leu Cys Phe Leu Val 2730 2735 2740 act aaa ttt aaa cgt gtt ttt ggt gat ctt tct tat ggt gtt ttt 8532 Thr Lys Phe Lys Arg Val Phe Gly Asp Leu Ser Tyr Gly Val Phe 2745 2750 2755 act gtt gtt tgt gca act ttg att aat aac att tct tat gtt gtt 8577 Thr Val Val Cys Ala Thr Leu Ile Asn Asn Ile Ser Tyr Val Val 2760 2765 2770 act caa aat tta ttt ttt atg ttg ctt tat gct att ttg tat ttt 8622 Thr Gln Asn Leu Phe Phe Met Leu Leu Tyr Ala Ile Leu Tyr Phe 2775 2780 2785 gtt ttt act agg aca gtg cgt tat gct tgg att tgg cat att gca 8667 Val Phe Thr Arg Thr Val Arg Tyr Ala Trp Ile Trp His Ile Ala 2790 2795 2800 tac att gtt gca tac ttc ttg tta ata cca tgg tgg ctt ctc aca 8712 Tyr Ile Val Ala Tyr Phe Leu Leu Ile Pro Trp Trp Leu Leu Thr 2805 2810 2815 tgg ttt agt ttt gct gca ttt tta gag ctt tta cct aat gtt ttt 8757 Trp Phe Ser Phe Ala Ala Phe Leu Glu Leu Leu Pro Asn Val Phe 2820 2825 2830 aag tta aaa atc tct act caa ttg ttt gaa ggt gat aag ttt ata 8802 Lys Leu Lys Ile Ser Thr Gln Leu Phe Glu Gly Asp Lys Phe Ile 2835 2840 2845 ggt act ttt gag agt gct gct gca ggt aca ttt gtt ctt gac atg 8847 Gly Thr Phe Glu Ser Ala Ala Ala Gly Thr Phe Val Leu Asp Met 2850 2855 2860 cgt tct tat gaa agg ctg ata aat act att tca cct gag aaa ctt 8892 Arg Ser Tyr Glu Arg Leu Ile Asn Thr Ile Ser Pro Glu Lys Leu 2865 2870 2875 aag aat tat gct gca agt tat aat aaa tat aaa tat tat agt ggt 8937 Lys Asn Tyr Ala Ala Ser Tyr Asn Lys Tyr Lys Tyr Tyr Ser Gly 2880 2885 2890 agt gct agt gag gct gat tat cgt tgt gct tgt tat gct cat tta 8982 Ser Ala Ser Glu Ala Asp Tyr Arg Cys Ala Cys Tyr Ala His Leu 2895 2900 2905 gcc aag gct atg tta gat tac gca aaa gat cat aat gac atg tta 9027 Ala Lys Ala Met Leu Asp Tyr Ala Lys Asp His Asn Asp Met Leu 2910 2915 2920 tat tct cca cct acc att agc tac aat tcc acc tta caa tct ggt 9072 Tyr Ser Pro Pro Thr Ile Ser Tyr Asn Ser Thr Leu Gln Ser Gly 2925 2930 2935 ctt aag aag atg gca caa cca tct ggt tgt gtt gag aga tgt gtg 9117 Leu Lys Lys Met Ala Gln Pro Ser Gly Cys Val Glu Arg Cys Val 2940 2945 2950 gtt cgc gtc tgt tat ggt agt act gtg ctt aat gga gtt tgg tta 9162 Val Arg Val Cys Tyr Gly Ser Thr Val Leu Asn Gly Val Trp Leu 2955 2960 2965 ggt gac act gtt act tgt cct aga cat gtc ata gca cca tca acc 9207 Gly Asp Thr Val Thr Cys Pro Arg His Val Ile Ala Pro Ser Thr 2970 2975 2980 act gtt ctt att gat tat gat cat gca tat agt act atg cgt ttg 9252 Thr Val Leu Ile Asp Tyr Asp His Ala Tyr Ser Thr Met Arg Leu 2985 2990 2995 cat aat ttt tca gtg tct cat aat ggt gtc ttc ttg gga gtt gtt 9297 His Asn Phe Ser Val Ser His Asn Gly Val Phe Leu Gly Val Val 3000 3005 3010 ggt gtt aca atg cat ggt tct gtg ttg cgt att aag gtt tca caa 9342 Gly Val Thr Met His Gly Ser Val Leu Arg Ile Lys Val Ser Gln 3015 3020 3025 tct aat gta cat aca cct aaa cat gtt ttt aaa acg ttg aaa cct 9387 Ser Asn Val His Thr Pro Lys His Val Phe Lys Thr Leu Lys Pro 3030 3035 3040 ggt gct tct ttt aat att tta gca tgt tat gaa ggt att gca tct 9432 Gly Ala Ser Phe Asn Ile Leu Ala Cys Tyr Glu Gly Ile Ala Ser 3045 3050 3055 ggt gtt ttt ggt gtt aat tta cgt aca aac ttt act att aaa ggt 9477 Gly Val Phe Gly Val Asn Leu Arg Thr Asn Phe Thr Ile Lys Gly 3060 3065 3070 tct ttt ata aat gga gct tgt ggt tct cct ggt tat aat gtt aga 9522 Ser Phe Ile Asn Gly Ala Cys Gly Ser Pro Gly Tyr Asn Val Arg 3075 3080 3085 aat gat ggt act gtt gag ttt tgt tat tta cac caa att gag tta 9567 Asn Asp Gly Thr Val Glu Phe Cys Tyr Leu His Gln Ile Glu Leu 3090 3095 3100 ggt agt ggt gct cat gtt ggt tct gat ttt act ggt agt gtt tat 9612 Gly Ser Gly Ala His Val Gly Ser Asp Phe Thr Gly Ser Val Tyr 3105 3110 3115 ggt aat ttt gat gac caa cct agt ttg caa gtt gag agt gcc aac 9657 Gly Asn Phe Asp Asp Gln Pro Ser Leu Gln Val Glu Ser Ala Asn 3120 3125 3130 ctt atg cta tca gat aat gtt gtt gcc ttt ttg tat gct gct ttg 9702 Leu Met Leu Ser Asp Asn Val Val Ala Phe Leu Tyr Ala Ala Leu 3135 3140 3145 ttg aat ggt tgt agg tgg tgg ttg cgt tca act aga gtt aat gtt 9747 Leu Asn Gly Cys Arg Trp Trp Leu Arg Ser Thr Arg Val Asn Val 3150 3155 3160 gat ggt ttt aat gaa tgg gct atg gct aat ggt tat aca att gtt 9792 Asp Gly Phe Asn Glu Trp Ala Met Ala Asn Gly Tyr Thr Ile Val 3165 3170 3175 tct agt gtt gag tgc tat tct att ttg gca gca aaa act ggt gtt 9837 Ser Ser Val Glu Cys Tyr Ser Ile Leu Ala Ala Lys Thr Gly Val 3180 3185 3190 agt gtt gaa caa ttg tta gct tcc att caa cat ctt cat gaa ggt 9882 Ser Val Glu Gln Leu Leu Ala Ser Ile Gln His Leu His Glu Gly 3195 3200 3205 ttt ggt ggt aaa aac ata ctt ggt tat tct agt tta tgt gat gag 9927 Phe Gly Gly Lys Asn Ile Leu Gly Tyr Ser Ser Leu Cys Asp Glu 3210 3215 3220 ttc aca cta gct gaa gtt gtg aag cag atg tat ggt gtt aac ttg 9972 Phe Thr Leu Ala Glu Val Val Lys Gln Met Tyr Gly Val Asn Leu 3225 3230 3235 caa agt ggt aag gtt att ttt ggt tta aaa aca atg ttt tta ttt 10017 Gln Ser Gly Lys Val Ile Phe Gly Leu Lys Thr Met Phe Leu Phe 3240 3245 3250 agc gtt ttc ttc aca atg ttt tgg gca gaa ctc ttt att tat aca 10062 Ser Val Phe Phe Thr Met Phe Trp Ala Glu Leu Phe Ile Tyr Thr 3255 3260 3265 aac act ata tgg ata aac cct gtt ata ctt aca cct ata ttt tgt 10107 Asn Thr Ile Trp Ile Asn Pro Val Ile Leu Thr Pro Ile Phe Cys 3270 3275 3280 tta ctt ttg ttt ttg tca tta gtt tta act atg ttt ctt aaa cat 10152 Leu Leu Leu Phe Leu Ser Leu Val Leu Thr Met Phe Leu Lys His 3285 3290 3295 aag ttt ttg ttt ttg caa gta ttt tta tta cct act gtt att gca 10197 Lys Phe Leu Phe Leu Gln Val Phe Leu Leu Pro Thr Val Ile Ala 3300 3305 3310 act gct tta tat aat tgt gtt ttg gat tat tac ata gta aaa ttt 10242 Thr Ala Leu Tyr Asn Cys Val Leu Asp Tyr Tyr Ile Val Lys Phe 3315 3320 3325 ttg gct gac cat ttt aac tat aat gtt tca gta tta caa atg gat 10287 Leu Ala Asp His Phe Asn Tyr Asn Val Ser Val Leu Gln Met Asp 3330 3335 3340 gtt cag ggt tta gtt aat gtt ttg gtc tgt tta ttt gtt gta ttt 10332 Val Gln Gly Leu Val Asn Val Leu Val Cys Leu Phe Val Val Phe 3345 3350 3355 tta cac aca tgg cgt ttt tct aaa gaa cgt ttc aca cat tgg ttt 10377 Leu His Thr Trp Arg Phe Ser Lys Glu Arg Phe Thr His Trp Phe 3360 3365 3370 aca tat gtg tgt tct ctt ata gca gtt gct tac act tat ttt tat 10422 Thr Tyr Val Cys Ser Leu Ile Ala Val Ala Tyr Thr Tyr Phe Tyr 3375 3380 3385 agt ggt gac ttt ttg agt ttg ctt gtt atg ttt tta tgt gct ata 10467 Ser Gly Asp Phe Leu Ser Leu Leu Val Met Phe Leu Cys Ala Ile 3390 3395 3400 tct agt gat tgg tac att ggt gcc att gtt ttt agg ttg tca cgt 10512 Ser Ser Asp Trp Tyr Ile Gly Ala Ile Val Phe Arg Leu Ser Arg 3405 3410 3415 ttg att ata ttt ttt tca cct gaa agt gta ttt agt gtt ttt ggt 10557 Leu Ile Ile Phe Phe Ser Pro Glu Ser Val Phe Ser Val Phe Gly 3420 3425 3430 gat gtg aaa ctc act tta gtt gtt tat tta att tgt ggt tat tta 10602 Asp Val Lys Leu Thr Leu Val Val Tyr Leu Ile Cys Gly Tyr Leu 3435 3440 3445 gtt tgt act tat tgg ggc att ttg tat tgg ttc aat agg ttt ttt 10647 Val Cys Thr Tyr Trp Gly Ile Leu Tyr Trp Phe Asn Arg Phe Phe 3450 3455 3460 aaa tgt act atg ggt gtt tat gat ttt aag gtg agt gct gct gaa 10692 Lys Cys Thr Met Gly Val Tyr Asp Phe Lys Val Ser Ala Ala Glu 3465 3470 3475 ttt aaa tac atg gtt gct aat gga ctt cat gca cca tat gga cct 10737 Phe Lys Tyr Met Val Ala Asn Gly Leu His Ala Pro Tyr Gly Pro 3480 3485 3490 ttt gat gca ctt tgg tta tca ttc aaa tta ctt ggt att ggt ggt 10782 Phe Asp Ala Leu Trp Leu Ser Phe Lys Leu Leu Gly Ile Gly Gly 3495 3500 3505 gac cgt tgt ata aaa att tca act gtc caa tcc aaa ctg act gat 10827 Asp Arg Cys Ile Lys Ile Ser Thr Val Gln Ser Lys Leu Thr Asp 3510 3515 3520 ttg aag tgt act aat gtt gtg tta ttg ggt tgt ttg tct agt atg 10872 Leu Lys Cys Thr Asn Val Val Leu Leu Gly Cys Leu Ser Ser Met 3525 3530 3535 aac att gca gct aat tct agt gaa tgg gct tat tgt gtt gat tta 10917 Asn Ile Ala Ala Asn Ser Ser Glu Trp Ala Tyr Cys Val Asp Leu 3540 3545 3550 cac aat aag att aat ctt tgt gat gac cca gaa aaa gct caa ggt 10962 His Asn Lys Ile Asn Leu Cys Asp Asp Pro Glu Lys Ala Gln Gly 3555 3560 3565 atg ttg tta gca ctc ctt gcg ttc ttt cta agt aaa cat agt gat 11007 Met Leu Leu Ala Leu Leu Ala Phe Phe Leu Ser Lys His Ser Asp 3570 3575 3580 ttt ggt ctt gat ggc ctt att gat tct tat ttt gat aat agt agc 11052 Phe Gly Leu Asp Gly Leu Ile Asp Ser Tyr Phe Asp Asn Ser Ser 3585 3590 3595 acc ctg cag agt gtt gct tca tca ttt gtt agt atg cca tca tat 11097 Thr Leu Gln Ser Val Ala Ser Ser Phe Val Ser Met Pro Ser Tyr 3600 3605 3610 att gct tat gaa aat gct aga caa gct tat gag gat gct att gct 11142 Ile Ala Tyr Glu Asn Ala Arg Gln Ala Tyr Glu Asp Ala Ile Ala 3615 3620 3625 aat gga tct tct tct caa ctt att aaa caa ttg aag cgt gcc atg 11187 Asn Gly Ser Ser Ser Gln Leu Ile Lys Gln Leu Lys Arg Ala Met 3630 3635 3640 aat atc gca aag tct gaa ttt gat cat gag ata tct gtt cag aag 11232 Asn Ile Ala Lys Ser Glu Phe Asp His Glu Ile Ser Val Gln Lys 3645 3650 3655 aaa att aat aga atg gct gaa caa gct gct act cag atg tat aaa 11277 Lys Ile Asn Arg Met Ala Glu Gln Ala Ala Thr Gln Met Tyr Lys 3660 3665 3670 gaa gca cgc tct gtt aat aga aaa tct aaa gtt att agt gct atg 11322 Glu Ala Arg Ser Val Asn Arg Lys Ser Lys Val Ile Ser Ala Met 3675 3680 3685 cac tct tta ctt ttt gga atg tta aga cgt ttg gat atg tct agt 11367 His Ser Leu Leu Phe Gly Met Leu Arg Arg Leu Asp Met Ser Ser 3690 3695 3700 gtt gaa act gtt ttg aat tta gca cgt gat ggt gtt gtg cca ttg 11412 Val Glu Thr Val Leu Asn Leu Ala Arg Asp Gly Val Val Pro Leu 3705 3710 3715 tca gtt ata cct gca act tca gct tcc aaa cta act att gtt agt 11457 Ser Val Ile Pro Ala Thr Ser Ala Ser Lys Leu Thr Ile Val Ser 3720 3725 3730 cca gat ctt gaa tct tat tct aag att gtt tgt gat ggt tct gtt 11502 Pro Asp Leu Glu Ser Tyr Ser Lys Ile Val Cys Asp Gly Ser Val 3735 3740 3745 cat tat gct gga gtt gtt tgg aca ctt aat gat gtt aaa gac aat 11547 His Tyr Ala Gly Val Val Trp Thr Leu Asn Asp Val Lys Asp Asn 3750 3755 3760 gat ggt aga cct gtt cat gtt aaa gag att aca agg gag aat gtt 11592 Asp Gly Arg Pro Val His Val Lys Glu Ile Thr Arg Glu Asn Val 3765 3770 3775 gaa act ttg aca tgg cct ctt atc ctt aat tgt gaa cgt gtt gtt 11637 Glu Thr Leu Thr Trp Pro Leu Ile Leu Asn Cys Glu Arg Val Val 3780 3785 3790 aaa ctt caa aat aat gaa att atg cct ggt aaa ctt aag caa aaa 11682 Lys Leu Gln Asn Asn Glu Ile Met Pro Gly Lys Leu Lys Gln Lys 3795 3800 3805 cct atg aaa gct gag ggt gat ggt ggt gtt tta ggt gat ggt aat 11727 Pro Met Lys Ala Glu Gly Asp Gly Gly Val Leu Gly Asp Gly Asn 3810 3815 3820 gct ttg tat aat act gag ggt ggt aaa act ttt atg tat gct tat 11772 Ala Leu Tyr Asn Thr Glu Gly Gly Lys Thr Phe Met Tyr Ala Tyr 3825 3830 3835 att tct aat aaa gct gac ctt aaa ttt gtt aag tgg gag tat gag 11817 Ile Ser Asn Lys Ala Asp Leu Lys Phe Val Lys Trp Glu Tyr Glu 3840 3845 3850 ggt ggt tgc aac aca atc gag tta gac tct cct tgt cga ttt atg 11862 Gly Gly Cys Asn Thr Ile Glu Leu Asp Ser Pro Cys Arg Phe Met 3855 3860 3865 gtc gaa aca cct aat ggt cct caa gtg aag tat ttg tat ttt gtt 11907 Val Glu Thr Pro Asn Gly Pro Gln Val Lys Tyr Leu Tyr Phe Val 3870 3875 3880 aaa aat tta aat acc tta cgt aga ggt gcc gtt ctt ggt ttt ata 11952 Lys Asn Leu Asn Thr Leu Arg Arg Gly Ala Val Leu Gly Phe Ile 3885 3890 3895 ggt gcc aca att cgt cta caa gct ggt aaa caa act gaa ttg gct 11997 Gly Ala Thr Ile Arg Leu Gln Ala Gly Lys Gln Thr Glu Leu Ala 3900 3905 3910 gtt aat tct gga ctt tta act gct tgt gct ttt tct gtt gat cca 12042 Val Asn Ser Gly Leu Leu Thr Ala Cys Ala Phe Ser Val Asp Pro 3915 3920 3925 gca acc act tac ttg gaa gct gtt aaa cat ggt gca aaa cct gta 12087 Ala Thr Thr Tyr Leu Glu Ala Val Lys His Gly Ala Lys Pro Val 3930 3935 3940 agt aat tgt att aag atg tta tct aat ggt gct ggt aat ggt caa 12132 Ser Asn Cys Ile Lys Met Leu Ser Asn Gly Ala Gly Asn Gly Gln 3945 3950 3955 gct ata aca act agt gta gat gct aac acc aat caa gat tct tat 12177 Ala Ile Thr Thr Ser Val Asp Ala Asn Thr Asn Gln Asp Ser Tyr 3960 3965 3970 ggt gga gcg tct att tgt ttg tat tgt cgg gcc cac gtt cct cac 12222 Gly Gly Ala Ser Ile Cys Leu Tyr Cys Arg Ala His Val Pro His 3975 3980 3985 cct agt atg gat ggt tac tgt aag ttt aag ggt aaa tgt gtt cag 12267 Pro Ser Met Asp Gly Tyr Cys Lys Phe Lys Gly Lys Cys Val Gln 3990 3995 4000 gtt cct att ggt tgt ttg gat cct att agg ttt tgt tta gaa aat 12312 Val Pro Ile Gly Cys Leu Asp Pro Ile Arg Phe Cys Leu Glu Asn 4005 4010 4015 aat gtg tgt aat gtt tgt ggt tgt tgg ttg gga cac ggg tgt gct 12357 Asn Val Cys Asn Val Cys Gly Cys Trp Leu Gly His Gly Cys Ala 4020 4025 4030 tgt gat cgt aca acc att caa agt gtt gac att tct tat tta aac 12402 Cys Asp Arg Thr Thr Ile Gln Ser Val Asp Ile Ser Tyr Leu Asn 4035 4040 4045 gag caa ggg gtt cta gtg cag ctc gac tag aaccctgtaa tggcacggac 12452 Glu Gln Gly Val Leu Val Gln Leu Asp 4050 4055 atcgataagt gtgttcgtgc ttttgacatt tataataaaa atgtttcatt cttgggtaag 12512 tgtttgaaga tgaactgtgt tcgttttaaa aatgctgatc ttaaggatgg ttattttgtt 12572 ataaagaggt gtactaagtc ggttatggaa cacgagcaat ccatgtataa cctacttaac 12632 ttttctggtg ctttggctga gcatgatttc tttacttgga aagatggcag agtcatttat 12692 ggtaatgtta gtagacataa tcttactaaa tatactatga tggacttggt ttatgctatg 12752 cgtaactttg atgaacaaaa ttgtgatgtt ctaaaagaag tattagtttt aactggttgt 12812 tgtgacaatt cttattttga tagtaagggt tggtatgacc cagttgaaaa tgaagatata 12872 catagagttt atgcatctct tggcaaaatt gtagctagag ctatgcttaa atgcgttgct 12932 ctatgtgatg cgatggttgc taaaggtgtt gttggtgttt taacattaga taaccaagat 12992 cttaatggta acttttatga ttttggtgat tttgttgtta gcttacctaa tatgggtgtt 13052 ccctgttgta catcatatta ttcttatatg atgcctatta tgggtttaac taattgttta 13112 gctagtgagt gttttgtcaa gagtgatatt tttggtagtg attttaaaac ttttgatttg 13172 cttaagtatg atttcactga acataaagaa aatttattca ataagtactt taagcattgg 13232 agttttgatt atcatcctaa ttgtagtgac tgttatgatg atatgtgtgt tatacattgt 13292 gctaatttta atacactatt tgccacaact ataccaggta ctgcttttgg tccactatgt 13352 cgtaaagttt ttatagatgg tgttccactt gttacaactg ctggttatca ttttaagcaa 13412 ttaggtttgg tttggaataa agatgttaac acacactcag ttaggttgac aatcactgaa 13472 cttttgcaat ttgttactga cccttccttg ataatagctt cttctccagc actcgttgat 13532 caacgcacta tttgtttttc tgttgcagca ttgagtactg gtttgacaaa tcaagttgtt 13592 aagccaggtc attttaatga agagttttat aactttcttc gtttaagagg tttctttgat 13652 gaaggttctg aacttacatt aaaacatttc ttcttcgcac agaatggtga tgctgctgtt 13712 aaagattttg acttttaccg ttataataag cctaccattt tagatatttg tcaagctaga 13772 gttacatata agatagtctc tcgttatttt gacatttatg aaggtggctg tattaaggca 13832 tgtgaagttg ttgtaacaaa tcttaataag agtgctggtt ggccattaaa taagtttggt 13892 aaagctagtt tgtattacga atctatatct tatgaagaac aggatgcttt gtttgctttg 13952 acaaagcgta atgtcctccc tactatgaca cagctgaatc ttaagtatgc tattagtggt 14012 aaagaacgtg ctagaactgt tggtggtgtt tctctgttgt ccacaatgac cacaagacaa 14072 taccatcaaa aacatcttaa atccattgtt aatacacgca atgccactgt tgttattggt 14132 actaccaaat tttatggtgg ttggaataat atgttgcgta ctttaattga tggtgttgaa 14192 aaccctatgc tcatgggttg ggattatccc aaatgtgata gagctttgcc taacatgata 14252 cgtatgattt cagccatggt gttgggttct aagcatgtta attgttgtac tgtaacagat 14312 aggttttata ggcttggtaa cgagttggca caagttttaa cagaagttgt ttattctaat 14372 ggtggttttt attttaagcc aggtggtacg acttctggtg acgctagtac agcttatgct 14432 aattctattt ttaacatttt tcaagccgtg agttctaaca ttaacaggtt gcttagtgtc 14492 ccatcagatt catgtaataa tgttaatgtt agggatctac aacgacgtct gtatgataat 14552 tgctataggt taactagtgt tgaagagtca ttcattgatg attattatgg ttatcttagg 14612 aaacattttt caatgatgat tctctctgat gacggtgttg tctgttataa caaggattat 14672 gctgagttag gttatatagc agacattagt gcttttaaag ccactttgta ttaccagaat 14732 aatgtcttta tgagtacttc taaatgttgg gttgaagaag atttaactaa gggaccacat 14792 gagttttgtt cccagcatac tatgcaaata gttgataaag atggtaccta ttatttgcct 14852 tacccagatc ctagtaggat cttgtcagct ggtgtttttg ttgatgatgt tgttaagaca 14912 gatgctgttg ttttgttaka acgttatgtg tctttagcta ttgatgcata ccctctttca 14972 aaacacccta attctgaata tcgtaaggtt ttttacgtat tacttgattg ggttaagcat 15032 cttaacaaaa atttgaatga gggtgttctt gaatcttttt ctgttacact tcttgataat 15092 caagaagata agttttggtg tgaagatttt tatgctagta tgtatgaaaa ttctacaata 15152 ttgcaagctg ctggcttatg tgttgtttgt ggttcacaaa ctgttcttcg ttgtggtgat 15212 tgtctgcgta agcctatgtt gtgcactaaa tgtgcatatg atcatgtatt tggtaccgac 15272 cacaagttta ttttggctat aacaccgtat gtatgtaatg catcaggttg tggtgttagt 15332 gatgttaaaa aattgtatct tggtggtttg aattactatt gtacaaatca taaaccacag 15392 ttgtcttttc cattatgttc tgctggtaat atatttggtt tatataaaaa ttcagcaact 15452 ggttccttag atgttgaagt ttttaatagg cttgcaacgt ctgattggac tgatgttagg 15512 gactataaac ttgctaatga tgttaaagat acacttagac tctttgcggc tgaaactatt 15572 aaagctaaag aagagagtgt taagtcttct tatgcttttg caactcttaa agaggttgtt 15632 ggacctaaag aattgcttct tagttgggaa agtggtaaag ttaaaccacc tttgaatcgt 15692 aattctgttt tcacctgttt tcaaataagt aaggactcaa aattccaaat aggtgagttc 15752 atctttgaaa aggttgaata tggttctgat actgttacgt ataagtctac tgtaaccact 15812 aagttagttc ctggtatgat ttttgtctta acatctcaca atgttcaacc tttacgtgca 15872 ccaactattg caaaccaaga gaagtattct agcatttata aattgcaccc tgcttttaat 15932 gtcagtgatg catatgctaa tttggttcca tattaccaac ttattggtaa acaaaagata 15992 actacaatac agggtcctcc tggtagtggt aagtcacatt gttccattgg acttggattg 16052 tactatccag gtgcgcgtat tgtttttgtt gcttgtgccc atgctgctgt tgattcctta 16112 tgtgcaaaag ctatgactgt ttatagcatt gataagtgta ctaggattat acctgcaaga 16172 gctcgggttg agtgttatag tggctttaaa ccaaataaca ctagtgcaca atacatattt 16232 agcactgtta acgcattacc tgagtgtaat gctgatattg ttgttgtaga tgaagtttca 16292 atgtgtacaa attatgacct ttctgttatt aatcagcgtt tatcatataa acatattgtt 16352 tatgttggtg atccacaaca acttcctgca cctagagtaa tgattactaa aggtgttatg 16412 gagcctgttg attataacgt tgttactcaa cgtatgtgtg ctataggccc tgatgttttt 16472 cttcataaat gttatagatg tcctgctgaa atagttaata cagtttctga acttgtttat 16532 gagaacaagt ttgtccctgt taaacctgct agtaaacagt gttttaaaat cttttttaag 16592 ggtaatgtac aggttgacaa tggctctagt attaacagaa agcagcttga aatagttaag 16652 ctgtttttag ttaaaaatcc aagttggagt aaggctgtgt ttatttctcc ttataatagt 16712 cagaattatg ttgctagtag atttttagga cttcaaattc aaactgttga ttcttctcaa 16772 ggtagtgagt atgattatgt aatctatgca caaacttctg acactgcaca tgcttgcaat 16832 gtaaaccgtt ttaatgttgc tataacacgt gctaagaagg gtatattttg tgtaatgtgt 16892 gataaaactt tgtttgattc acttaagttt tttgagatta aacatgcaga tttacactct 16952 agccaggttt gtggcttgtt taaaaattgt acacgcactc ctcttaattt accaccaact 17012 catgcacaca ctttcttgtc gttgtcagat cagtttaaga ctacaggtga tttagctgtt 17072 caaataggtt caaataatgt ttgtacttat gaacatgtta tatcatttat gggttttagg 17132 tttgatatta gtattcctgg tagtcatagt ttgttttgta cacgtgactt tgctattcgt 17192 aatgtgcgtg gttggttggg tatggatgtt gaaagtgctc atgtttgtgg cgataacata 17252 ggtactaatg ttcctttaca ggttggtttt tcaaatggtg ttaattttgt tgtgcaaact 17312 gaaggttgtg tgtctaccaa ttttggtgat gttattaaac ctgtttgtgc aaaatctcca 17372 ccaggtgaac aatttagaca ccttgttcct tttttacgta aaggacaacc ttggttaatt 17432 gttcgtagac gcattgtgca aatgatatct gattatttgt ccaatttgtc tgacattctt 17492 gtctttgttt tgtgggcagg tagtttggaa ttaactacaa tgcgttactt tgtaaaaata 17552 gggccaatta aatattgtta ttgtggtaat tctgccactt gttataattc agttagtaat 17612 gaatattgtt gttttaaaca tgcattgggt tgtgattatg tttacaatcc gtatgctttt 17672 gatatacaac agtggggtta tgttggttcc ttgagccaga accaccacac gttctgtaac 17732 attcatagaa acgagcatga tgcttctggt gatgctgtta tgacacgttg tttggcagta 17792 catgattgtt ttgtcaaaaa tgttgattgg actgtaacgt acccctttat tgcaaatgag 17852 aaatttatca atggctgtgg gcgtaatgtc cagggacatg ttgttcgcgc agccttgaaa 17912 ttgtataaac ctagtgttat tcatgatatt ggtaatccta aaggtgtacg ttgtgctgtt 17972 actgatgcca aatggtactg ttatgacaag caacctgtta atagtaatgt caagttgttg 18032 gattatgatt atgcaaccca tggtcaactt gatggtcttt gtttattctg gaattgtaat 18092 gttgatatgt atccagaatt ttcaattgtg tgtcgctttg acacacgtac tcgttctgtt 18152 tttaatttag aaggtgttaa tggtggttct ctttatgtta acaaacatgc gtttcataca 18212 ccagcatatg ataaacgtgc ttttgttaaa ttaaaaccta tgcccttttt ttactttgat 18272 gacagtgatt gtgatgttgt gcaagaacaa gttaattatg taccccttcg cgctagtagt 18332 tgtgttaccc gttgtaatat aggtggtgct gtttgttcaa aacatgcaaa tttgtatcaa 18392 aaatatgttg aggcatataa tacatttaca caggctggtt ttaacatttg ggtaccacat 18452 agttttgatg tttataattt gtggcaaatt tttattgaaa ctaatttaca aagtcttgaa 18512 aatatagcat ttaatgttgt aaaaaaaggg tgttttactg gtgttgatgg tgagttacct 18572 gttgcagttg ttaacgacaa agtttttgtt cgctatggcg atgttgacaa cttggttttt 18632 acaaataaaa caacattgcc tactaatgtt gcttttgaat tgtttgcaaa acgaaaaatg 18692 ggtttaacac caccattgtc tattctcaaa aatcttggtg ttgttgctac atataaattt 18752 gttttatggg attatgaagc tgaaagacct tttacctcat atactaagag tgtatgtaaa 18812 tacactgatt ttaatgagga tgtttgtgtt tgttttgaca atagtattca gggttcgtat 18872 gagcgtttta cgcttactac gaacgctgtt ttattttcta ctgttgtcat taaaaattta 18932 acacctataa agttgaattt tggtatgttg aatggtatgc cagtttcttc tattaagagt 18992 gataaaggtg ttgaaaaatt agttaattgg tacacatatg ttcgtaaaaa tggtcaattt 19052 caagatcatt atgatggttt ttacactcaa ggtaggaatt tatcagactt tacaccaaga 19112 agtgatatgg agtatgattt tcttaacatg gatatgggtg tttttattaa taaatatggt 19172 cttgaggatt ttaattttga acatgttgta tatggtgatg tttcaaaaac tacattagga 19232 ggtcttcatt tgttgatatc acagtttagg cttagtaaaa tgggtgtttt gaaagctgat 19292 gattttgtca ctgcttctga cacaactttg aggtgctgta ctgttactta tcttaatgaa 19352 cttagttcaa aagttgtttg tacttatatg gatttgttgt tggacgactt tgttactata 19412 ctaaagagtt tagatcttgg tgtaatatct aaagttcatg aagttattat agataataaa 19472 ccttataggt ggatgttgtg gtgtaaagat aaccacttgt ccacttttta tccacagttg 19532 cagtctgctg aatggaagtg tggttatgct atgccacaaa tttataagct tcaacgtatg 19592 tgtttggaac cttgtaattt atataattat ggtgctggta ttaagttgcc tagtggtata 19652 atgttaaatg ttgttaaata cactcagctt tgtcaatacc taaatagcac tacaatgtgc 19712 gtacctcata atatgcgtgt tttgcactat ggtgctggtt ctgacaaagg tgtggcacct 19772 ggtacaactg ttttaaaacg ttggctacca cctgatgcaa taatcattga taatgatatc 19832 aatgattatg ttagtgatgc agattttagc attacaggtg attgtgctac tgtttacctt 19892 gaagataagt ttgacttact tatttctgat atgtatgatg gtagaattaa attttgtgat 19952 ggtgaaaacg tctctaaaga tggttttttt acttatctta atggtgttat tagagaaaaa 20012 ttagctattg gtggtagtgt tgccattaag attacagaat atagttggaa taagtatctt 20072 tatgaattaa tacaaagatt tgctttttgg actttgttct gcacgtctgt taatacatcc 20132 tcttcagaag cttttcttat tggtattaat tatttaggtg actttattca aggtcctttt 20192 atagctggta acactgttca tgctaattat atattttggc gtaattctac tattatgtct 20252 ttgtcataca attcagtttt agatttaagt aagtttgaat gtaaacataa ggccactgtt 20312 gttgttacac ttaaagatag tgatgtaaat gatatggttt tgagtttgat taagagtggt 20372 aggttgttgt tacgtaatag tggccgtttt ggtggtttta gtaatcattt agtctcaact 20432 aa atg aaa ctt ttc ttg att ttg ctt att ttg ccc ctg gtt tct tgc 20479 Met Lys Leu Phe Leu Ile Leu Leu Ile Leu Pro Leu Val Ser Cys 4060 4065 4070 ttt tct aca tgt aac agt aat gct agt att tct atg tta caa tta 20524 Phe Ser Thr Cys Asn Ser Asn Ala Ser Ile Ser Met Leu Gln Leu 4075 4080 4085 ggt gtt cct gat aac tct tca act att gtc aca ggt ttg ttg cca 20569 Gly Val Pro Asp Asn Ser Ser Thr Ile Val Thr Gly Leu Leu Pro 4090 4095 4100 gtc cat tgg att tgt gct aat cag agt aca tct agt tac cca gcc 20614 Val His Trp Ile Cys Ala Asn Gln Ser Thr Ser Ser Tyr Pro Ala 4105 4110 4115 aac ggc ttt ttc tat att gat gtt ggt aaa cac cgt agt gcc ttt 20659 Asn Gly Phe Phe Tyr Ile Asp Val Gly Lys His Arg Ser Ala Phe 4120 4125 4130 gca ctc cat agt ggt tat tat gat gct aac cag tat tat att tat 20704 Ala Leu His Ser Gly Tyr Tyr Asp Ala Asn Gln Tyr Tyr Ile Tyr 4135 4140 4145 ctc act aat aaa ata cat tta aat gct cct gtc act ctg aag att 20749 Leu Thr Asn Lys Ile His Leu Asn Ala Pro Val Thr Leu Lys Ile 4150 4155 4160 tgt aag ttt gga aac act tct ttt gat ttt tta agt aat gtt tct 20794 Cys Lys Phe Gly Asn Thr Ser Phe Asp Phe Leu Ser Asn Val Ser 4165 4170 4175 act tct cat gat tgt ata gtt aat ttg tca ttc aca gaa cag tta 20839 Thr Ser His Asp Cys Ile Val Asn Leu Ser Phe Thr Glu Gln Leu 4180 4185 4190 ggt gtg cct ttg ggc ata act ata tcg ggt gaa act gta cgt ttg 20884 Gly Val Pro Leu Gly Ile Thr Ile Ser Gly Glu Thr Val Arg Leu 4195 4200 4205 cat tta tat aat gca act cgt act ttt tat gtg ccg gcc gct tat 20929 His Leu Tyr Asn Ala Thr Arg Thr Phe Tyr Val Pro Ala Ala Tyr 4210 4215 4220 aaa ctt act aaa ctt agt gtt aaa tgt tac ttt agt gaa tcc tgt 20974 Lys Leu Thr Lys Leu Ser Val Lys Cys Tyr Phe Ser Glu Ser Cys 4225 4230 4235 gtt ttt agt gtt gtc aat gcc acc att act gtt aat gtc acc aca 21019 Val Phe Ser Val Val Asn Ala Thr Ile Thr Val Asn Val Thr Thr 4240 4245 4250 ctt aat ggc cgt ata gtt aac tac act gtt tgt gat gat tgt aat 21064 Leu Asn Gly Arg Ile Val Asn Tyr Thr Val Cys Asp Asp Cys Asn 4255 4260 4265 ggt tat act gat aac ata ttt tct gtt caa cag gat ggc cgc att 21109 Gly Tyr Thr Asp Asn Ile Phe Ser Val Gln Gln Asp Gly Arg Ile 4270 4275 4280 cct aat ggt ttc cct ttt aat aat tgg ttt ttg tta act aat ggt 21154 Pro Asn Gly Phe Pro Phe Asn Asn Trp Phe Leu Leu Thr Asn Gly 4285 4290 4295 tcc aca tta gtg gac ggg gtc tct aga ctt tat caa cca ctc cgt 21199 Ser Thr Leu Val Asp Gly Val Ser Arg Leu Tyr Gln Pro Leu Arg 4300 4305 4310 tta act tgt tta tgg cct gta cct ggt ctt aaa tct tca act ggt 21244 Leu Thr Cys Leu Trp Pro Val Pro Gly Leu Lys Ser Ser Thr Gly 4315 4320 4325 ttt gtt tat ttt aat gcc act ggt tct gat gtt aat tgt aac ggc 21289 Phe Val Tyr Phe Asn Ala Thr Gly Ser Asp Val Asn Cys Asn Gly 4330 4335 4340 tat caa cat aat tct gtt gct gat gtt atg cgt tac aat ctt aac 21334 Tyr Gln His Asn Ser Val Ala Asp Val Met Arg Tyr Asn Leu Asn 4345 4350 4355 ctc agt gct aat tct gtg gac aat ctt aag agt ggt gtt ata gtt 21379 Leu Ser Ala Asn Ser Val Asp Asn Leu Lys Ser Gly Val Ile Val 4360 4365 4370 ttt aaa act tta cag tac gat gtt ttg ttt tat tgt agt aat tct 21424 Phe Lys Thr Leu Gln Tyr Asp Val Leu Phe Tyr Cys Ser Asn Ser 4375 4380 4385 tct tca ggt gtt ctt gac acc aca ata cct ttt ggc cct tcc tct 21469 Ser Ser Gly Val Leu Asp Thr Thr Ile Pro Phe Gly Pro Ser Ser 4390 4395 4400 caa cct tat tac tgt ttt ata aac agt act atc aac act act cat 21514 Gln Pro Tyr Tyr Cys Phe Ile Asn Ser Thr Ile Asn Thr Thr His 4405 4410 4415 gtt agc act ttt gtg ggt att tta cca ccc act gtg cgt gaa att 21559 Val Ser Thr Phe Val Gly Ile Leu Pro Pro Thr Val Arg Glu Ile 4420 4425 4430 gtt gtt gct aga act ggt cag ttt tat att aat ggt ttt aag tat 21604 Val Val Ala Arg Thr Gly Gln Phe Tyr Ile Asn Gly Phe Lys Tyr 4435 4440 4445 ttc gat ttg ggt ttc ata gaa gct gtc aat ttt aat gtc acg act 21649 Phe Asp Leu Gly Phe Ile Glu Ala Val Asn Phe Asn Val Thr Thr 4450 4455 4460 gct agt gcc aca gat ttt tgg acg gtt gca ttt gct act ttt gtt 21694 Ala Ser Ala Thr Asp Phe Trp Thr Val Ala Phe Ala Thr Phe Val 4465 4470 4475 gat gtt ttg gtt aat gtt agt gca act aac att caa aac tta ctt 21739 Asp Val Leu Val Asn Val Ser Ala Thr Asn Ile Gln Asn Leu Leu 4480 4485 4490 tat tgc gat tct cca ttt gaa aag ttg cag tgt gag cac ttg cag 21784 Tyr Cys Asp Ser Pro Phe Glu Lys Leu Gln Cys Glu His Leu Gln 4495 4500 4505 ttt gga ttg caa gat ggt ttt tat tct gca aat ttt ctt gat gat 21829 Phe Gly Leu Gln Asp Gly Phe Tyr Ser Ala Asn Phe Leu Asp Asp 4510 4515 4520 aat gtt ttg cct gag act tat gtt gca ctc ccc att tat tat caa 21874 Asn Val Leu Pro Glu Thr Tyr Val Ala Leu Pro Ile Tyr Tyr Gln 4525 4530 4535 cat acg gac ata aat ttt act gca act gca tct ttt ggt ggt tct 21919 His Thr Asp Ile Asn Phe Thr Ala Thr Ala Ser Phe Gly Gly Ser 4540 4545 4550 tgt tat gtt tgt aaa cca cgc cag gtt aat ata tct ctt aat ggt 21964 Cys Tyr Val Cys Lys Pro Arg Gln Val Asn Ile Ser Leu Asn Gly 4555 4560 4565 aac act tca gtg tgt gtt aga aca tct cat ttt tca att agg tat 22009 Asn Thr Ser Val Cys Val Arg Thr Ser His Phe Ser Ile Arg Tyr 4570 4575 4580 att tat aac cgc gtt aag agt ggt tca cca ggt gac tct tca tgg 22054 Ile Tyr Asn Arg Val Lys Ser Gly Ser Pro Gly Asp Ser Ser Trp 4585 4590 4595 cat att tat tta aag agt ggc act tgt cca ttt tct ttt tct aag 22099 His Ile Tyr Leu Lys Ser Gly Thr Cys Pro Phe Ser Phe Ser Lys 4600 4605 4610 tta aat aat ttt caa aag ttt aag act att tgt ttc tca acc gtc 22144 Leu Asn Asn Phe Gln Lys Phe Lys Thr Ile Cys Phe Ser Thr Val 4615 4620 4625 gaa gtg cct ggt agt tgt aat ttt cca ctt gaa gcc acc tgg cat 22189 Glu Val Pro Gly Ser Cys Asn Phe Pro Leu Glu Ala Thr Trp His 4630 4635 4640 tac act tct tat act att gtt ggt gct ttg tat gtt act tgg tct 22234 Tyr Thr Ser Tyr Thr Ile Val Gly Ala Leu Tyr Val Thr Trp Ser 4645 4650 4655 gaa ggt aat tcc att act ggt gta cct tat cct gtc tct ggt att 22279 Glu Gly Asn Ser Ile Thr Gly Val Pro Tyr Pro Val Ser Gly Ile 4660 4665 4670 cgt gag ttt agt aat tta gtt tta aat aat tgt acc aaa tat aat 22324 Arg Glu Phe Ser Asn Leu Val Leu Asn Asn Cys Thr Lys Tyr Asn 4675 4680 4685 att tat gat tat gtt ggt act gga att ata cgt tct tca aac cag 22369 Ile Tyr Asp Tyr Val Gly Thr Gly Ile Ile Arg Ser Ser Asn Gln 4690 4695 4700 tca ctt gct ggt ggt att aca tat gtt tct aac tct ggt aat tta 22414 Ser Leu Ala Gly Gly Ile Thr Tyr Val Ser Asn Ser Gly Asn Leu 4705 4710 4715 ctt ggt ttt aaa aat gtt tcc act ggt aac att ttt att gtg aca 22459 Leu Gly Phe Lys Asn Val Ser Thr Gly Asn Ile Phe Ile Val Thr 4720 4725 4730 cca tgt aac caa cca gat caa gta gct gtt tat caa caa agc att 22504 Pro Cys Asn Gln Pro Asp Gln Val Ala Val Tyr Gln Gln Ser Ile 4735 4740 4745 att ggt gcc atg acc gct gtt aat gag tct aga tat ggc ttg caa 22549 Ile Gly Ala Met Thr Ala Val Asn Glu Ser Arg Tyr Gly Leu Gln 4750 4755 4760 aac tta cta cag tta cct aac ttt tat tat gtt agt aat ggt ggt 22594 Asn Leu Leu Gln Leu Pro Asn Phe Tyr Tyr Val Ser Asn Gly Gly 4765 4770 4775 aac aat tgc act acg gct gtt atg att tat tct aat ttt ggt att 22639 Asn Asn Cys Thr Thr Ala Val Met Ile Tyr Ser Asn Phe Gly Ile 4780 4785 4790 tgt gct gat ggt tct tta att cct gtt cgt ccg cgt aat tct agt 22684 Cys Ala Asp Gly Ser Leu Ile Pro Val Arg Pro Arg Asn Ser Ser 4795 4800 4805 gat aat ggt att tca gcc ata atc act gct aat tta tcc att ccc 22729 Asp Asn Gly Ile Ser Ala Ile Ile Thr Ala Asn Leu Ser Ile Pro 4810 4815 4820 tct aac tgg act act tca gtt caa gtt gag tac ctc caa att act 22774 Ser Asn Trp Thr Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr 4825 4830 4835 agt act cca ata gtt gtt gat tgt gct act tat gtg tgt aat ggt 22819 Ser Thr Pro Ile Val Val Asp Cys Ala Thr Tyr Val Cys Asn Gly 4840 4845 4850 aac cct cgt tgt aag aat cta ctt aag cag tat act tct gct tgt 22864 Asn Pro Arg Cys Lys Asn Leu Leu Lys Gln Tyr Thr Ser Ala Cys 4855 4860 4865 aaa act att gaa gat gcc tta cga ctt agt gct cat ttg gaa act 22909 Lys Thr Ile Glu Asp Ala Leu Arg Leu Ser Ala His Leu Glu Thr 4870 4875 4880 aat gat gtt agt agt atg cta act ttc gat agc aat gct ttt agt 22954 Asn Asp Val Ser Ser Met Leu Thr Phe Asp Ser Asn Ala Phe Ser 4885 4890 4895 ttg gct aat gtt act agt ttt gga gat tat aac ctt tct agt gtt 22999 Leu Ala Asn Val Thr Ser Phe Gly Asp Tyr Asn Leu Ser Ser Val 4900 4905 4910 tta cct cag aga aac att cat tca agc cgt ata gca gga cgt agt 23044 Leu Pro Gln Arg Asn Ile His Ser Ser Arg Ile Ala Gly Arg Ser 4915 4920 4925 gct ttg gaa gat ttg ttg ttt agc aaa gtt gtt aca tct ggt ttg 23089 Ala Leu Glu Asp Leu Leu Phe Ser Lys Val Val Thr Ser Gly Leu 4930 4935 4940 ggt act gtt gat gtt gac tat aag tct tgt act aaa ggt ctt tct 23134 Gly Thr Val Asp Val Asp Tyr Lys Ser Cys Thr Lys Gly Leu Ser 4945 4950 4955 att gct gac ctt gct tgt gct cag tac tac aat ggc ata atg gtt 23179 Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn Gly Ile Met Val 4960 4965 4970 ttg cca ggt gtt gct gat gct gaa cgt atg gcc atg tac aca ggt 23224 Leu Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met Tyr Thr Gly 4975 4980 4985 tct ctt ata ggt ggc atg gtg ctc gga ggt ctt aca tca gca gcc 23269 Ser Leu Ile Gly Gly Met Val Leu Gly Gly Leu Thr Ser Ala Ala 4990 4995 5000 gcc ata cct ttt tct ttg gca ctg caa gca cga ctt aac tat gtt 23314 Ala Ile Pro Phe Ser Leu Ala Leu Gln Ala Arg Leu Asn Tyr Val 5005 5010 5015 gct tta caa act gat gtg ctt caa gaa aat cag aaa att ttg gct 23359 Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala 5020 5025 5030 gca tca ttt aat aag gct att aat aat att gtt gct tct ttt agt 23404 Ala Ser Phe Asn Lys Ala Ile Asn Asn Ile Val Ala Ser Phe Ser 5035 5040 5045 agc gtt aat gat gct att aca cat act gca gag gct ata cat act 23449 Ser Val Asn Asp Ala Ile Thr His Thr Ala Glu Ala Ile His Thr 5050 5055 5060 gtt act att gca ctt aat aag att cag gat gtt gtt aat caa cag 23494 Val Thr Ile Ala Leu Asn Lys Ile Gln Asp Val Val Asn Gln Gln 5065 5070 5075 ggt agt gct ctt aac cat ctc act tca caa ttg aga cat aat ttt 23539 Gly Ser Ala Leu Asn His Leu Thr Ser Gln Leu Arg His Asn Phe 5080 5085 5090 cag gcc att tct aat tca att cat gct att tat gac cgg ctt gat 23584 Gln Ala Ile Ser Asn Ser Ile His Ala Ile Tyr Asp Arg Leu Asp 5095 5100 5105 tca att caa gcc gat caa caa gtt gac aga tta att act gga cgg 23629 Ser Ile Gln Ala Asp Gln Gln Val Asp Arg Leu Ile Thr Gly Arg 5110 5115 5120 ctt gca gct ttg aat gca ttt gtt tcc caa gtt ttg aat aaa tat 23674 Leu Ala Ala Leu Asn Ala Phe Val Ser Gln Val Leu Asn Lys Tyr 5125 5130 5135 act gaa gtt cgt ggt tcc aga cgc tta gca cag cag aag att aat 23719 Thr Glu Val Arg Gly Ser Arg Arg Leu Ala Gln Gln Lys Ile Asn 5140 5145 5150 gaa tgt gtc aag tca caa tct aat aga tat ggt ttt tgt ggc aat 23764 Glu Cys Val Lys Ser Gln Ser Asn Arg Tyr Gly Phe Cys Gly Asn 5155 5160 5165 ggc act cac atc ttt tca atc gtc aac tca gct cca gat ggt ttg 23809 Gly Thr His Ile Phe Ser Ile Val Asn Ser Ala Pro Asp Gly Leu 5170 5175 5180 ctt ttt ctt cat act gtt ttg ctg cca act gat tac aag aat gta 23854 Leu Phe Leu His Thr Val Leu Leu Pro Thr Asp Tyr Lys Asn Val 5185 5190 5195 aag gcg tgg tct ggt atc tgt gtt gat ggc att tat ggc tat gtt 23899 Lys Ala Trp Ser Gly Ile Cys Val Asp Gly Ile Tyr Gly Tyr Val 5200 5205 5210 ctg cgt caa cct aac ttg gtt ctt tat tct gat aat ggt gtc ttt 23944 Leu Arg Gln Pro Asn Leu Val Leu Tyr Ser Asp Asn Gly Val Phe 5215 5220 5225 cgt gta act tcc agg gtc atg ttt caa cct cgt tta cct gtt ttg 23989 Arg Val Thr Ser Arg Val Met Phe Gln Pro Arg Leu Pro Val Leu 5230 5235 5240 tct gat ttt gtg caa ata tat aat tgt aat gtt act ttt gtt aac 24034 Ser Asp Phe Val Gln Ile Tyr Asn Cys Asn Val Thr Phe Val Asn 5245 5250 5255 ata tct cgt gtc gag tta cat act gtc ata cct gac tac gtt gat 24079 Ile Ser Arg Val Glu Leu His Thr Val Ile Pro Asp Tyr Val Asp 5260 5265 5270 gtt aat aaa aca tta caa gag ttt gca caa aac tta cca aag tat 24124 Val Asn Lys Thr Leu Gln Glu Phe Ala Gln Asn Leu Pro Lys Tyr 5275 5280 5285 gtt aag cct aat ttt gac ttg act cct ttt aat tta aca tat ctt 24169 Val Lys Pro Asn Phe Asp Leu Thr Pro Phe Asn Leu Thr Tyr Leu 5290 5295 5300 aat ttg agt tct gag ttg aag caa ctc gaa gct aaa act gct agt 24214 Asn Leu Ser Ser Glu Leu Lys Gln Leu Glu Ala Lys Thr Ala Ser 5305 5310 5315 ctt ttc caa act act gtt gaa tta caa ggt ctt att gat cag att 24259 Leu Phe Gln Thr Thr Val Glu Leu Gln Gly Leu Ile Asp Gln Ile 5320 5325 5330 aac agt aca tat gtt gat ttg aag ttg ctt aat agg ttt gaa aat 24304 Asn Ser Thr Tyr Val Asp Leu Lys Leu Leu Asn Arg Phe Glu Asn 5335 5340 5345 tat atc aaa tgg cct tgg tgg gtt tgg ctc att att tct gtt gtt 24349 Tyr Ile Lys Trp Pro Trp Trp Val Trp Leu Ile Ile Ser Val Val 5350 5355 5360 ttt gtt gta ttg ttg agt ctt ctt gtg ttt tgt tgt ctt tct aca 24394 Phe Val Val Leu Leu Ser Leu Leu Val Phe Cys Cys Leu Ser Thr 5365 5370 5375 ggt tgt tgt ggt tgt tgc aat tgt tta act tca tca atg cga ggc 24439 Gly Cys Cys Gly Cys Cys Asn Cys Leu Thr Ser Ser Met Arg Gly 5380 5385 5390 tgt tgt gat tgt ggt tca act aaa ctt cct tat tat gaa ttt gaa 24484 Cys Cys Asp Cys Gly Ser Thr Lys Leu Pro Tyr Tyr Glu Phe Glu 5395 5400 5405 aag gtc cac gtt caa taa tgcctttcgg tggcctattt caacttactc 24532 Lys Val His Val Gln 5410 ttgaaagtac tattaataag agtgtggcta atctcaaatt accacctcat gatgttactg 24592 tcttgcgtga caatcttaaa cctgttacta cacttagtac tatcactgct tatttgttag 24652 ttagtttgtt tgtcacttat tttgctttat tcaaacctct tactgctaga ggtcgtgttg 24712 cttgttttgt tttaaaacta ttgacactat ctgtctatgt gcctttattg gttctttttg 24772 gtatgtatct tgacagtttt ataatttttt ttctacgctg ttgtttcgat tcatacatgt 24832 tggctattat gcctatctct aataaaaatt tttcatttgt tttgttcaat gttactaaac 24892 tatgcttcgt ttcaggcaag tgttggtatc ttgaacaatc attttatgaa aatcgttttg 24952 ctgctattta tggtggtgac cactatgtcg ttttaggtgg tgaaactatt acttttgttt 25012 cttttgatga cctttatgtt gctattagag gttcttgtga aaagaaccta caacttatgc 25072 gtaaggttga cttgtataat ggtgctgtca tttacatttt tgccgaagag cctgttgttg 25132 gtatagttta ctcctctcaa ctatacgaag atg ttc ctt cga tta att gat gac 25186 Met Phe Leu Arg Leu Ile Asp Asp 5415 aat ggc att gtc ctc aat tct att tta tgg ctc ctt gtt atg ata 25231 Asn Gly Ile Val Leu Asn Ser Ile Leu Trp Leu Leu Val Met Ile 5420 5425 5430 ttt ttc ttt gtg ttg gca atg acc ttt att aaa ctg att caa ttg 25276 Phe Phe Phe Val Leu Ala Met Thr Phe Ile Lys Leu Ile Gln Leu 5435 5440 5445 tgt ttt act tgt cat tat ttt ttt agt agg aca tta tat caa cca 25321 Cys Phe Thr Cys His Tyr Phe Phe Ser Arg Thr Leu Tyr Gln Pro 5450 5455 5460 gtt tat aaa att ttt ctt gct tac caa gat tat atg caa ata gca 25366 Val Tyr Lys Ile Phe Leu Ala Tyr Gln Asp Tyr Met Gln Ile Ala 5465 5470 5475 cct gtt cca gct gaa gta cta aat gtc taa actaaacg atg tct aat 25413 Pro Val Pro Ala Glu Val Leu Asn Val Met Ser Asn 5480 5485 5490 agt agt gtg cct ctt tca gag gtt tat gtc cat tta cgt aac tgg 25458 Ser Ser Val Pro Leu Ser Glu Val Tyr Val His Leu Arg Asn Trp 5495 5500 5505 aac ttt agt tgg aat tta att cta aca gtt ttt ata gtt gtg ttg 25503 Asn Phe Ser Trp Asn Leu Ile Leu Thr Val Phe Ile Val Val Leu 5510 5515 5520 cag tat ggg cat tat aag tat agc aga ctt ctt tat ggt tta aag 25548 Gln Tyr Gly His Tyr Lys Tyr Ser Arg Leu Leu Tyr Gly Leu Lys 5525 5530 5535 atg tct gtt tta tgg tgt tta tgg cca ctt gtt cta gct ttg tct 25593 Met Ser Val Leu Trp Cys Leu Trp Pro Leu Val Leu Ala Leu Ser 5540 5545 5550 att ttt gac tgt ttt gtc aat ttt aat gtg gac tgg gtc ttt ttt 25638 Ile Phe Asp Cys Phe Val Asn Phe Asn Val Asp Trp Val Phe Phe 5555 5560 5565 ggt ttt agt att ctt atg tct att att aca ctt tgt tta tgg gtt 25683 Gly Phe Ser Ile Leu Met Ser Ile Ile Thr Leu Cys Leu Trp Val 5570 5575 5580 atg tat ttt gtt aat agt ttc aga ctt tgg cgc cgt gtt aaa act 25728 Met Tyr Phe Val Asn Ser Phe Arg Leu Trp Arg Arg Val Lys Thr 5585 5590 5595 ttt tgg gct ttt aat cct gaa act aat gca atc atc tct ctc cag 25773 Phe Trp Ala Phe Asn Pro Glu Thr Asn Ala Ile Ile Ser Leu Gln 5600 5605 5610 gtt tat gga cat aat tat tac tta ccg gtg atg gct gca cct aca 25818 Val Tyr Gly His Asn Tyr Tyr Leu Pro Val Met Ala Ala Pro Thr 5615 5620 5625 ggt gtt aca tta aca ctt ctt agt ggt gta ctt ctt gtt gat ggc 25863 Gly Val Thr Leu Thr Leu Leu Ser Gly Val Leu Leu Val Asp Gly 5630 5635 5640 cat aag att gct act cgt gtt caa gtg ggt cag ttg cct aaa tat 25908 His Lys Ile Ala Thr Arg Val Gln Val Gly Gln Leu Pro Lys Tyr 5645 5650 5655 gta ata gtt gct aca cct agt acc aca att gtt tgt gac cgt gtt 25953 Val Ile Val Ala Thr Pro Ser Thr Thr Ile Val Cys Asp Arg Val 5660 5665 5670 ggt cgc tct gtt aat gaa aca agc cag act ggt tgg gca ttc tac 25998 Gly Arg Ser Val Asn Glu Thr Ser Gln Thr Gly Trp Ala Phe Tyr 5675 5680 5685 gtc cgt gct aaa cat ggt gat ttt tct ggt gtt gcc tct cag gag 26043 Val Arg Ala Lys His Gly Asp Phe Ser Gly Val Ala Ser Gln Glu 5690 5695 5700 ggt gtt ttg tca gaa aga gag aag ttg ctt cat tta atc taa 26085 Gly Val Leu Ser Glu Arg Glu Lys Leu Leu His Leu Ile 5705 5710 actaaacaaa atg gct agt gta aat tgg gcc gat gac aga gct gct agg 26134 Met Ala Ser Val Asn Trp Ala Asp Asp Arg Ala Ala Arg 5715 5720 5725 aag aaa ttt cct cct cct tca ttt tac atg cct ctt ttg gtt agt 26179 Lys Lys Phe Pro Pro Pro Ser Phe Tyr Met Pro Leu Leu Val Ser 5730 5735 5740 tct gat aag gca cca tat agg gtc att ccc agg aat ctt gtc cct 26224 Ser Asp Lys Ala Pro Tyr Arg Val Ile Pro Arg Asn Leu Val Pro 5745 5750 5755 att ggt aag ggt aat aaa gat gag cag att ggt tat tgg aat gtt 26269 Ile Gly Lys Gly Asn Lys Asp Glu Gln Ile Gly Tyr Trp Asn Val 5760 5765 5770 caa gag cgt tgg cgt atg cgc agg ggg caa cgt gtt gat ttg cct 26314 Gln Glu Arg Trp Arg Met Arg Arg Gly Gln Arg Val Asp Leu Pro 5775 5780 5785 cct aaa gtt cat ttt tat tac cta ggt act gga cct cat aag gac 26359 Pro Lys Val His Phe Tyr Tyr Leu Gly Thr Gly Pro His Lys Asp 5790 5795 5800 ctt aaa ttc aga caa cgt tct gat ggt gtt gtt tgg gtt gct aag 26404 Leu Lys Phe Arg Gln Arg Ser Asp Gly Val Val Trp Val Ala Lys 5805 5810 5815 gaa ggt gct aaa act gtt aat acc agt ctt ggt aat cgc aaa cgt 26449 Glu Gly Ala Lys Thr Val Asn Thr Ser Leu Gly Asn Arg Lys Arg 5820 5825 5830 aat cag aaa cct ttg gaa cca aag ttc tct att gct ttg cct cca 26494 Asn Gln Lys Pro Leu Glu Pro Lys Phe Ser Ile Ala Leu Pro Pro 5835 5840 5845 gag ctc tct gtt gtt gag ttt gag gat cgc tct aat aac tca tct 26539 Glu Leu Ser Val Val Glu Phe Glu Asp Arg Ser Asn Asn Ser Ser 5850 5855 5860 cgt gct agc agt cgt tct tca act cgt aac aac tca cga gac tct 26584 Arg Ala Ser Ser Arg Ser Ser Thr Arg Asn Asn Ser Arg Asp Ser 5865 5870 5875 tct cgt agt act tca aga caa cag tct cgc act cgt tct gat tct 26629 Ser Arg Ser Thr Ser Arg Gln Gln Ser Arg Thr Arg Ser Asp Ser 5880 5885 5890 aac cag tct tct tca gat ctt gtt gct gct gtt act ttg gct tta 26674 Asn Gln Ser Ser Ser Asp Leu Val Ala Ala Val Thr Leu Ala Leu 5895 5900 5905 aag aac tta ggt ttt gat aac cag tcg aag tca cct agt tct tct 26719 Lys Asn Leu Gly Phe Asp Asn Gln Ser Lys Ser Pro Ser Ser Ser 5910 5915 5920 ggt act tcc act cct aag aaa cct aat aag cct ctt tct caa ccc 26764 Gly Thr Ser Thr Pro Lys Lys Pro Asn Lys Pro Leu Ser Gln Pro 5925 5930 5935 agg gct gat aag cct tct cag ttg aag aaa cct cgt tgg aag cgt 26809 Arg Ala Asp Lys Pro Ser Gln Leu Lys Lys Pro Arg Trp Lys Arg 5940 5945 5950 gtt cct acc aga gag gaa aat gtt att cag tgc ttt ggt cct cgt 26854 Val Pro Thr Arg Glu Glu Asn Val Ile Gln Cys Phe Gly Pro Arg 5955 5960 5965 gat ttt aat cac aat atg ggg gat tca gat ctt gtt cag aat ggt 26899 Asp Phe Asn His Asn Met Gly Asp Ser Asp Leu Val Gln Asn Gly 5970 5975 5980 gtt gat gcc aag ggt ttt cca cag ctt gct gaa ttg att cct aat 26944 Val Asp Ala Lys Gly Phe Pro Gln Leu Ala Glu Leu Ile Pro Asn 5985 5990 5995 cag gct gcg tta ttc ttt gat agt gag gtt agc act gat gaa gtg 26989 Gln Ala Ala Leu Phe Phe Asp Ser Glu Val Ser Thr Asp Glu Val 6000 6005 6010 ggt gat aat gtt cag att acc tac acc tac aaa atg ctt gta gct 27034 Gly Asp Asn Val Gln Ile Thr Tyr Thr Tyr Lys Met Leu Val Ala 6015 6020 6025 aag gat aat aag aac ctt cct aag ttc att gag cag att agt gct 27079 Lys Asp Asn Lys Asn Leu Pro Lys Phe Ile Glu Gln Ile Ser Ala 6030 6035 6040 ttt act aaa ccc agt tct atc aaa gaa atg cag tca caa tca tct 27124 Phe Thr Lys Pro Ser Ser Ile Lys Glu Met Gln Ser Gln Ser Ser 6045 6050 6055 cat gtt gct cag aac aca gta ctt aat gct tct att cca gaa tct 27169 His Val Ala Gln Asn Thr Val Leu Asn Ala Ser Ile Pro Glu Ser 6060 6065 6070 aaa cca ttg gct gat gat gat tca gcc att ata gaa att gtc aac 27214 Lys Pro Leu Ala Asp Asp Asp Ser Ala Ile Ile Glu Ile Val Asn 6075 6080 6085 gag gtt ttg cat taa attgttttgt aattccagtt gaatgtttat tattattagt 27269 Glu Val Leu His 6090 tgcaacccca tgcgtttagc gcatgataag ggtttagtct tacacacaat ggtaggccag 27329 tgatagtaaa gtgtaagtaa tttgctatca tattaacatg tctagaggaa agtcagaact 27389 ttttctgttt gtgttgttgg agtacttaaa gatcgcatag gcgcgccaac aatggaagag 27449 ccaacaacat atctaaaaat gttttgtctg gtacttgtta atgatattgt ttttgatatg 27509 gatacacaaa aaaaaaaaaa a 27530 <210> 2 <211> 4055 <212> PRT <213> EMCR Coronavirus <400> 2 Met Phe Tyr Asn Gln Val Thr Leu Ala Val Ala Ser Asp Ser Glu Ile 1 5 10 15 Ser Gly Phe Gly Phe Ala Ile Pro Ser Val Ala Val Arg Ala Tyr Ser 20 25 30 Glu Ala Ala Ala Gln Gly Phe Gln Ala Cys Arg Phe Val Ala Phe Gly 35 40 45 Leu Gln Asp Cys Val Thr Gly Ile Asn Asp Asp Asp Tyr Val Ile Ala 50 55 60 Leu Thr Gly Thr Asn Gln Leu Cys Ala Lys Ile Leu Leu Phe Ser Asp 65 70 75 80 Arg Pro Leu Asn Leu Arg Gly Trp Leu Ile Phe Ser Asn Ser Asn Tyr 85 90 95 Val Leu Gln Asp Phe Asp Val Val Phe Gly His Gly Ala Gly Ser Val 100 105 110 Val Phe Val Asp Lys Tyr Met Cys Gly Phe Asp Gly Lys Pro Val Leu 115 120 125 Pro Lys Asn Met Trp Glu Phe Arg Asp Tyr Phe Asn Asp Asn Thr Asp 130 135 140 Ser Ile Val Ile Gly Gly Val Thr Tyr Gln Leu Ala Trp Asp Val Ile 145 150 155 160 Arg Lys Asp Leu Ser Tyr Glu Gln Gln Asn Val Leu Ala Ile Glu Ser 165 170 175 Ile His Tyr Leu Gly Thr Thr Gly His Thr Leu Lys Ser Gly Cys Lys 180 185 190 Leu Ile Asn Ala Lys Pro Pro Lys Tyr Ser Ser Lys Val Val Leu Ser 195 200 205 Gly Glu Trp Asn Ala Val Tyr Lys Ala Phe Gly Ser Pro Phe Ile Thr 210 215 220 Asn Gly Ile Ser Leu Leu Asp Ile Ile Val Lys Pro Val Phe Phe Asn 225 230 235 240 Ala Phe Val Lys Cys Asn Cys Gly Ser Glu Asn Trp Ser Val Gly Ala 245 250 255 Trp Asp Gly Tyr Leu Ser Ser Cys Cys Gly Thr Pro Ala Lys Lys Leu 260 265 270 Cys Val Val Pro Gly Asn Val Val Pro Gly Asp Val Ile Ile Thr Ser 275 280 285 Thr Asp Ala Gly Cys Gly Val Lys Tyr Tyr Ala Gly Leu Val Val Lys 290 295 300 His Ile Thr Asn Ile Thr Gly Val Ser Leu Trp Arg Val Thr Ala Val 305 310 315 320 His Ser Asp Gly Met Phe Val Ala Thr Ser Ser Tyr Asp Ala Leu Leu 325 330 335 His Arg Asn Ser Leu Asp Pro Phe Cys Phe Asp Val Asn Thr Leu Leu 340 345 350 Ser Asn Gln Leu Arg Leu Ala Phe Leu Gly Ala Ser Val Thr Glu Asp 355 360 365 Val Lys Phe Ala Ala Ser Thr Gly Val Ile Asp Ile Ser Ala Gly Met 370 375 380 Phe Gly Leu Tyr Asp Asp Ile Leu Thr Asn Asn Lys Pro Trp Phe Val 385 390 395 400 Arg Lys Ala Ser Gly Leu Phe Asp Ala Ile Trp Asp Ala Phe Val Ala 405 410 415 Ala Ile Lys Leu Val Pro Thr Thr Thr Gly Gly Leu Val Arg Phe Val 420 425 430 Lys Ser Ile Ala Ser Thr Val Leu Thr Val Ser Asn Gly Val Ile Ile 435 440 445 Met Cys Ala Asp Val Pro Asp Ala Phe Gln Pro Val Tyr Arg Thr Phe 450 455 460 Thr Gln Ala Ile Cys Ala Ala Phe Asp Phe Ser Leu Asp Val Phe Lys 465 470 475 480 Ile Gly Asp Val Lys Phe Lys Arg Leu Gly Asp Tyr Val Leu Thr Glu 485 490 495 Asn Ala Leu Val Arg Leu Thr Thr Glu Val Val Arg Gly Val Arg Asp 500 505 510 Ala Arg Ile Lys Lys Ala Met Phe Thr Lys Val Val Val Gly Pro Thr 515 520 525 Thr Glu Val Lys Phe Ser Val Ile Glu Leu Ala Thr Val Asn Leu Arg 530 535 540 Leu Val Asp Cys Ala Pro Val Val Cys Pro Lys Gly Lys Ile Val Val 545 550 555 560 Ile Ala Gly Gln Ala Phe Phe Tyr Ser Gly Gly Phe Tyr Arg Phe Met 565 570 575 Val Asp Ser Thr Thr Val Leu Asn Asp Pro Val Phe Thr Gly Glu Leu 580 585 590 Phe Tyr Thr Ile Lys Phe Ser Gly Phe Lys Leu Asp Gly Phe Asn His 595 600 605 Gln Phe Val Asn Ala Ser Ser Ala Thr Asp Ala Ile Ile Ala Val Glu 610 615 620 Leu Leu Leu Ser Asp Phe Lys Thr Ala Val Phe Val Tyr Thr Cys Val 625 630 635 640 Val Asp Gly Cys Ser Val Ile Val Arg Arg Asp Ala Thr Phe Ala Thr 645 650 655 His Val Cys Phe Lys Asp Cys Tyr Ser Ile Trp Glu Gln Phe Cys Ile 660 665 670 Asp Asn Cys Gly Glu Pro Trp Phe Leu Thr Asp Tyr Asn Ala Ile Leu 675 680 685 Gln Ser Asn Asn Pro Gln Cys Ala Ile Val Gln Ala Ser Glu Ser Lys 690 695 700 Val Leu Leu Glu Arg Phe Leu Pro Lys Cys Pro Glu Ile Leu Leu Ser 705 710 715 720 Ile Asp Asp Gly His Leu Trp Asn Leu Phe Val Glu Lys Phe Asn Phe 725 730 735 Val Thr Asp Trp Leu Lys Thr Leu Lys Leu Thr Leu Thr Ser Asn Gly 740 745 750 Leu Leu Gly Asn Cys Ala Lys Arg Phe Arg Arg Val Leu Val Lys Leu 755 760 765 Leu Asp Val Tyr Asn Gly Phe Leu Glu Thr Val Cys Ser Val Val His 770 775 780 Thr Ala Gly Val Cys Ile Lys Tyr Tyr Ala Val Asn Val Pro Tyr Val 785 790 795 800 Val Ile Ser Gly Phe Val Ser Arg Val Ile Arg Arg Glu Arg Cys Asp 805 810 815 Val Thr Phe Pro Cys Val Ser Cys Val Thr Phe Phe Tyr Glu Phe Leu 820 825 830 Asp Thr Cys Phe Gly Val Ser Lys Pro Asn Ala Ile Asp Val Glu His 835 840 845 Leu Glu Leu Lys Glu Thr Val Phe Val Glu Pro Lys Asp Gly Gly Gln 850 855 860 Phe Phe Val Ser Asp Asp Tyr Leu Trp Tyr Val Val Asp Asp Ile Tyr 865 870 875 880 Tyr Pro Ala Ser Cys Asn Gly Val Leu Pro Val Ala Phe Thr Lys Leu 885 890 895 Ala Gly Gly Lys Ile Ser Phe Ser Asp Asp Val Ile Val His Asp Val 900 905 910 Glu Pro Thr His Lys Val Lys Leu Ile Phe Glu Phe Glu Asp Asp Val 915 920 925 Val Thr Ser Leu Cys Lys Lys Ser Phe Gly Lys Ser Ile Ile Tyr Thr 930 935 940 Gly Asp Trp Glu Gly Leu His Glu Val Leu Thr Ser Ala Met Asn Val 945 950 955 960 Ile Gly Gln His Ile Lys Leu Pro Gln Phe Tyr Ile Tyr Asp Glu Glu 965 970 975 Gly Gly Tyr Asp Val Ser Lys Pro Val Met Ile Ser Gln Trp Pro Ile 980 985 990 Ser Asp Asp Ser Asp Gly Cys Val Val Glu Ala Ser Thr Asp Phe His 995 1000 1005 Gln Leu Glu Ser Val Arg Glu Glu Val Asp Ile Ile Glu Gln Pro 1010 1015 1020 Phe Gly Glu Val Glu His Ala Leu Ser Ile Arg Gln Pro Phe Ser 1025 1030 1035 Phe Ser Phe Arg Asp Glu Leu Gly Val Arg Val Leu Asp Gln Ser 1040 1045 1050 Asp Asn Asn Cys Trp Ile Ser Thr Thr Leu Ile Gln Leu Gln Leu 1055 1060 1065 Thr Lys Leu Leu Asp Asp Ser Ile Glu Met Gln Leu Phe Lys Val 1070 1075 1080 Gly Lys Val Asp Ser Ile Val Gln Lys Cys Tyr Glu Leu Ser His 1085 1090 1095 Leu Ile Ser Gly Ser Leu Gly Asp Ser Gly Lys Leu Leu Ser Glu 1100 1105 1110 Leu Leu Lys Asp Lys Tyr Thr Cys Ser Ile Thr Phe Glu Met Ser 1115 1120 1125 Cys Asp Cys Gly Lys Lys Phe Asp Glu Gln Val Gly Cys Leu Phe 1130 1135 1140 Trp Ile Met Pro Tyr Thr Lys Leu Phe Gln Lys Gly Glu Cys Cys 1145 1150 1155 Ile Cys His Lys Met Gln Thr Tyr Lys Leu Val Ser Met Lys Gly 1160 1165 1170 Thr Gly Val Phe Val Gln Asp Pro Ala Pro Ile Asp Ile Asp Ala 1175 1180 1185 Phe Pro Val Arg Pro Ile Cys Ser Ser Val Tyr Leu Gly Val Lys 1190 1195 1200 Gly Ser Gly His Tyr Gln Thr Asn Leu Tyr Ser Phe Asp Lys Ala 1205 1210 1215 Ile Asp Gly Phe Gly Val Phe Asp Ile Lys Asn Ser Ser Val Asn 1220 1225 1230 Thr Val Cys Phe Val Asp Val Asp Phe His Ser Val Glu Ile Glu 1235 1240 1245 Ala Gly Glu Val Lys Pro Phe Ala Val Tyr Lys Asn Val Lys Phe 1250 1255 1260 Tyr Leu Gly Asp Ile Ser His Leu Val Asn Cys Val Ser Phe Asp 1265 1270 1275 Phe Val Val Asn Ala Ala Asn Glu Asn Leu Met His Gly Gly Gly 1280 1285 1290 Val Ala Arg Ala Ile Asp Ile Leu Thr Glu Gly Gln Leu Gln Ser 1295 1300 1305 Leu Ser Lys Asp Tyr Ile Ser Ser Asn Gly Pro Leu Lys Val Gly 1310 1315 1320 Ala Gly Val Met Leu Glu Cys Glu Lys Phe Asn Val Phe Asn Val 1325 1330 1335 Val Gly Pro Arg Thr Gly Lys His Glu His Ser Leu Leu Val Glu 1340 1345 1350 Ala Tyr Asn Ser Ile Leu Phe Glu Asn Gly Ile Pro Leu Met Pro 1355 1360 1365 Leu Leu Ser Cys Gly Ile Phe Gly Val Arg Ile Glu Asn Ser Leu 1370 1375 1380 Lys Ala Leu Phe Ser Cys Asp Ile Asn Lys Pro Leu Gln Val Phe 1385 1390 1395 Val Tyr Ser Ser Asn Glu Glu Gln Ala Val Leu Lys Phe Leu Asp 1400 1405 1410 Gly Leu Asp Leu Thr Pro Val Ile Asp Asp Val Asp Val Val Lys 1415 1420 1425 Pro Phe Arg Val Glu Gly Asn Phe Ser Phe Phe Asp Cys Gly Val 1430 1435 1440 Asn Ala Leu Asp Gly Asp Ile Tyr Leu Leu Phe Thr Asn Ser Ile 1445 1450 1455 Leu Met Leu Asp Lys Gln Gly Gln Leu Leu Asp Thr Lys Leu Asn 1460 1465 1470 Gly Ile Leu Gln Gln Ala Val Leu Asp Tyr Leu Ala Thr Val Lys 1475 1480 1485 Thr Val Pro Ala Gly Asn Leu Val Lys Leu Val Val Glu Ser Cys 1490 1495 1500 Thr Ile Tyr Met Cys Val Val Pro Ser Ile Asn Asp Leu Ser Phe 1505 1510 1515 Asp Lys Asn Leu Gly Arg Cys Val Arg Lys Leu Asn Arg Leu Lys 1520 1525 1530 Thr Cys Val Ile Ala Asn Val Pro Ala Ile Asp Val Leu Lys Lys 1535 1540 1545 Leu Leu Ser Ser Leu Thr Leu Thr Val Lys Phe Val Val Glu Ser 1550 1555 1560 Asn Val Met Asp Val Asn Asp Cys Phe Lys Asn Asp Asn Val Val 1565 1570 1575 Leu Lys Ile Thr Glu Asp Gly Ile Asn Val Lys Asp Val Val Val 1580 1585 1590 Glu Ser Ser Lys Ser Leu Gly Lys Gln Leu Gly Val Val Ser Asp 1595 1600 1605 Gly Val Asp Ser Phe Glu Gly Val Leu Pro Ile Asn Thr Asp Thr 1610 1615 1620 Val Leu Ser Val Ala Pro Glu Val Asp Trp Val Ala Phe Tyr Gly 1625 1630 1635 Phe Glu Lys Ala Ala Leu Phe Ala Ser Leu Asp Val Lys Pro Tyr 1640 1645 1650 Gly Tyr Pro Asn Asp Phe Val Gly Gly Phe Arg Val Leu Gly Thr 1655 1660 1665 Thr Asp Asn Asn Cys Trp Val Asn Ala Thr Cys Ile Ile Leu Gln 1670 1675 1680 Tyr Leu Lys Pro Thr Phe Lys Ser Lys Gly Leu Asn Val Leu Trp 1685 1690 1695 Asn Lys Phe Val Thr Gly Asp Val Gly Pro Phe Val Ser Phe Ile 1700 1705 1710 Tyr Phe Ile Thr Met Ser Ser Lys Gly Gln Lys Gly Asp Ala Glu 1715 1720 1725 Glu Ala Leu Ser Lys Leu Ser Glu Tyr Leu Ile Ser Asp Ser Ile 1730 1735 1740 Val Thr Leu Glu Gln Tyr Ser Thr Cys Asp Ile Cys Lys Ser Thr 1745 1750 1755 Val Val Glu Val Lys Ser Ala Val Val Cys Ala Ser Val Leu Lys 1760 1765 1770 Asp Gly Cys Asp Val Gly Phe Cys Pro His Arg His Lys Leu Arg 1775 1780 1785 Ser Arg Val Lys Phe Val Asn Gly Arg Val Val Ile Thr Asn Val 1790 1795 1800 Gly Glu Pro Ile Ile Ser Gln Pro Ser Lys Leu Leu Asn Gly Ile 1805 1810 1815 Ala Tyr Thr Thr Phe Ser Gly Ser Phe Asp Asn Gly His Tyr Val 1820 1825 1830 Val Tyr Asp Ala Ala Asn Asn Ala Val Tyr Asp Gly Ala Arg Leu 1835 1840 1845 Phe Ala Ser Asp Leu Ser Thr Leu Ala Val Thr Ala Ile Val Val 1850 1855 1860 Val Gly Gly Cys Val Thr Ser Asn Val Pro Pro Ile Val Ser Glu 1865 1870 1875 Lys Ile Ser Val Met Asp Lys Leu Asp Thr Gly Ala Gln Lys Phe 1880 1885 1890 Phe Gln Phe Gly Asp Phe Val Met Asn Asn Ile Val Leu Phe Leu 1895 1900 1905 Thr Trp Leu Leu Ser Met Phe Ser Leu Leu Arg Thr Ser Ile Met 1910 1915 1920 Lys His Asp Ile Lys Val Ile Ala Lys Ala Pro Lys Arg Thr Gly 1925 1930 1935 Val Ile Leu Thr Arg Ser Phe Lys Tyr Asn Ile Arg Ser Ala Leu 1940 1945 1950 Phe Val Val Lys Gln Lys Trp Cys Val Ile Val Thr Leu Phe Lys 1955 1960 1965 Phe Leu Leu Leu Leu Tyr Ala Ile Tyr Ala Leu Val Phe Met Ile 1970 1975 1980 Val Gln Phe Ser Pro Phe Asn Ser Leu Leu Cys Gly Asp Ile Val 1985 1990 1995 Ser Gly Tyr Glu Lys Ser Thr Phe Asn Lys Asp Ile Tyr Cys Gly 2000 2005 2010 Asn Ser Met Val Cys Lys Met Cys Leu Phe Ser Tyr Gln Glu Phe 2015 2020 2025 Asn Asp Leu Asp His Thr Ser Leu Val Trp Lys His Ile Arg Asp 2030 2035 2040 Pro Ile Leu Ile Ser Leu Gln Pro Phe Val Ile Leu Val Ile Leu 2045 2050 2055 Leu Ile Phe Gly Asn Met Tyr Leu Arg Phe Gly Leu Leu Tyr Phe 2060 2065 2070 Val Ala Gln Phe Ile Ser Thr Phe Gly Ser Phe Leu Gly Phe His 2075 2080 2085 Gln Lys Gln Trp Phe Leu His Phe Val Pro Phe Asp Val Leu Cys 2090 2095 2100 Asn Glu Phe Leu Ala Thr Phe Ile Val Cys Lys Ile Val Leu Phe 2105 2110 2115 Val Arg His Ile Ile Val Gly Cys Asn Asn Ala Asp Cys Val Ala 2120 2125 2130 Cys Ser Lys Ser Ala Arg Leu Lys Arg Val Pro Leu Gln Thr Ile 2135 2140 2145 Ile Asn Gly Met His Lys Ser Phe Tyr Val Asn Ala Asn Gly Gly 2150 2155 2160 Thr Cys Phe Cys Asn Lys His Asn Phe Phe Cys Val Asn Cys Asp 2165 2170 2175 Ser Phe Gly Pro Gly Asn Thr Phe Ile Asn Gly Asp Ile Ala Arg 2180 2185 2190 Glu Leu Gly Asn Val Val Lys Thr Ala Val Gln Pro Thr Ala Pro 2195 2200 2205 Ala Tyr Val Ile Ile Asp Lys Val Asp Phe Val Asn Gly Phe Tyr 2210 2215 2220 Arg Leu Tyr Ser Gly Asp Thr Phe Trp Arg Tyr Asp Phe Asp Ile 2225 2230 2235 Thr Glu Ser Lys Tyr Ser Cys Lys Glu Val Leu Lys Asn Cys Asn 2240 2245 2250 Val Leu Glu Asn Phe Ile Val Tyr Asn Asn Ser Gly Ser Asn Ile 2255 2260 2265 Thr Gln Ile Lys Asn Ala Cys Val Tyr Phe Ser Gln Leu Leu Cys 2270 2275 2280 Glu Pro Ile Lys Leu Val Asn Ser Glu Leu Leu Ser Thr Leu Ser 2285 2290 2295 Val Asp Phe Asn Gly Val Leu His Lys Ala Tyr Val Asp Val Leu 2300 2305 2310 Cys Asn Ser Phe Phe Lys Glu Leu Thr Ala Asn Met Ser Met Ala 2315 2320 2325 Glu Cys Lys Ala Thr Leu Gly Leu Thr Val Ser Asp Asp Asp Phe 2330 2335 2340 Val Ser Ala Val Ala Asn Ala His Arg Tyr Asp Val Leu Leu Ser 2345 2350 2355 Asp Leu Ser Phe Asn Asn Phe Phe Ile Ser Tyr Ala Lys Pro Glu 2360 2365 2370 Asp Lys Leu Ser Val Tyr Asp Ile Ala Cys Cys Met Arg Ala Gly 2375 2380 2385 Ser Lys Val Val Asn His Asn Val Leu Ile Lys Glu Ser Ile Pro 2390 2395 2400 Ile Val Trp Gly Val Lys Asp Phe Asn Thr Leu Ser Gln Glu Gly 2405 2410 2415 Lys Lys Tyr Leu Val Lys Thr Thr Lys Ala Lys Gly Leu Thr Phe 2420 2425 2430 Leu Leu Thr Phe Asn Asp Asn Gln Ala Ile Thr Gln Val Pro Ala 2435 2440 2445 Thr Ser Ile Val Ala Lys Gln Gly Ala Gly Phe Lys Arg Thr Tyr 2450 2455 2460 Asn Phe Leu Trp Tyr Val Cys Leu Phe Val Val Ala Leu Phe Ile 2465 2470 2475 Gly Val Ser Phe Ile Asp Tyr Thr Thr Thr Val Thr Ser Phe His 2480 2485 2490 Gly Tyr Asp Phe Lys Tyr Ile Glu Asn Gly Gln Leu Lys Val Phe 2495 2500 2505 Glu Ala Pro Leu His Cys Val Arg Asn Val Phe Asp Asn Phe Asn 2510 2515 2520 Gln Trp His Glu Ala Lys Phe Gly Val Val Thr Thr Asn Ser Asp 2525 2530 2535 Lys Cys Pro Ile Val Val Gly Val Ser Glu Arg Ile Asn Val Val 2540 2545 2550 Pro Gly Val Pro Thr Asn Val Tyr Leu Val Gly Lys Thr Leu Val 2555 2560 2565 Phe Thr Leu Gln Ala Ala Phe Gly Asn Thr Gly Val Cys Tyr Asp 2570 2575 2580 Phe Asp Gly Val Thr Thr Ser Asp Lys Cys Ile Phe Asn Ser Ala 2585 2590 2595 Cys Thr Arg Leu Glu Gly Leu Gly Gly Asp Asn Val Tyr Cys Tyr 2600 2605 2610 Asn Thr Asp Leu Ile Glu Gly Ser Lys Pro Tyr Ser Ile Leu Gln 2615 2620 2625 Pro Asn Ala Tyr Tyr Lys Tyr Asp Val Lys Asn Tyr Val Arg Phe 2630 2635 2640 Pro Glu Ile Leu Ala Arg Gly Phe Gly Leu Arg Thr Ile Arg Thr 2645 2650 2655 Leu Ala Thr Arg Tyr Cys Arg Val Gly Glu Cys Arg Asp Ser His 2660 2665 2670 Lys Gly Val Cys Phe Gly Phe Asp Lys Trp Tyr Val Asn Asp Gly 2675 2680 2685 Arg Val Asp Asp Gly Tyr Ile Cys Gly Asp Gly Leu Ile Asp Leu 2690 2695 2700 Leu Val Asn Val Leu Ser Ile Phe Ser Ser Ser Phe Ser Val Val 2705 2710 2715 Ala Met Ser Gly His Met Leu Phe Asn Phe Leu Phe Ala Ala Phe 2720 2725 2730 Ile Thr Phe Leu Cys Phe Leu Val Thr Lys Phe Lys Arg Val Phe 2735 2740 2745 Gly Asp Leu Ser Tyr Gly Val Phe Thr Val Val Cys Ala Thr Leu 2750 2755 2760 Ile Asn Asn Ile Ser Tyr Val Val Thr Gln Asn Leu Phe Phe Met 2765 2770 2775 Leu Leu Tyr Ala Ile Leu Tyr Phe Val Phe Thr Arg Thr Val Arg 2780 2785 2790 Tyr Ala Trp Ile Trp His Ile Ala Tyr Ile Val Ala Tyr Phe Leu 2795 2800 2805 Leu Ile Pro Trp Trp Leu Leu Thr Trp Phe Ser Phe Ala Ala Phe 2810 2815 2820 Leu Glu Leu Leu Pro Asn Val Phe Lys Leu Lys Ile Ser Thr Gln 2825 2830 2835 Leu Phe Glu Gly Asp Lys Phe Ile Gly Thr Phe Glu Ser Ala Ala 2840 2845 2850 Ala Gly Thr Phe Val Leu Asp Met Arg Ser Tyr Glu Arg Leu Ile 2855 2860 2865 Asn Thr Ile Ser Pro Glu Lys Leu Lys Asn Tyr Ala Ala Ser Tyr 2870 2875 2880 Asn Lys Tyr Lys Tyr Tyr Ser Gly Ser Ala Ser Glu Ala Asp Tyr 2885 2890 2895 Arg Cys Ala Cys Tyr Ala His Leu Ala Lys Ala Met Leu Asp Tyr 2900 2905 2910 Ala Lys Asp His Asn Asp Met Leu Tyr Ser Pro Pro Thr Ile Ser 2915 2920 2925 Tyr Asn Ser Thr Leu Gln Ser Gly Leu Lys Lys Met Ala Gln Pro 2930 2935 2940 Ser Gly Cys Val Glu Arg Cys Val Val Arg Val Cys Tyr Gly Ser 2945 2950 2955 Thr Val Leu Asn Gly Val Trp Leu Gly Asp Thr Val Thr Cys Pro 2960 2965 2970 Arg His Val Ile Ala Pro Ser Thr Thr Val Leu Ile Asp Tyr Asp 2975 2980 2985 His Ala Tyr Ser Thr Met Arg Leu His Asn Phe Ser Val Ser His 2990 2995 3000 Asn Gly Val Phe Leu Gly Val Val Gly Val Thr Met His Gly Ser 3005 3010 3015 Val Leu Arg Ile Lys Val Ser Gln Ser Asn Val His Thr Pro Lys 3020 3025 3030 His Val Phe Lys Thr Leu Lys Pro Gly Ala Ser Phe Asn Ile Leu 3035 3040 3045 Ala Cys Tyr Glu Gly Ile Ala Ser Gly Val Phe Gly Val Asn Leu 3050 3055 3060 Arg Thr Asn Phe Thr Ile Lys Gly Ser Phe Ile Asn Gly Ala Cys 3065 3070 3075 Gly Ser Pro Gly Tyr Asn Val Arg Asn Asp Gly Thr Val Glu Phe 3080 3085 3090 Cys Tyr Leu His Gln Ile Glu Leu Gly Ser Gly Ala His Val Gly 3095 3100 3105 Ser Asp Phe Thr Gly Ser Val Tyr Gly Asn Phe Asp Asp Gln Pro 3110 3115 3120 Ser Leu Gln Val Glu Ser Ala Asn Leu Met Leu Ser Asp Asn Val 3125 3130 3135 Val Ala Phe Leu Tyr Ala Ala Leu Leu Asn Gly Cys Arg Trp Trp 3140 3145 3150 Leu Arg Ser Thr Arg Val Asn Val Asp Gly Phe Asn Glu Trp Ala 3155 3160 3165 Met Ala Asn Gly Tyr Thr Ile Val Ser Ser Val Glu Cys Tyr Ser 3170 3175 3180 Ile Leu Ala Ala Lys Thr Gly Val Ser Val Glu Gln Leu Leu Ala 3185 3190 3195 Ser Ile Gln His Leu His Glu Gly Phe Gly Gly Lys Asn Ile Leu 3200 3205 3210 Gly Tyr Ser Ser Leu Cys Asp Glu Phe Thr Leu Ala Glu Val Val 3215 3220 3225 Lys Gln Met Tyr Gly Val Asn Leu Gln Ser Gly Lys Val Ile Phe 3230 3235 3240 Gly Leu Lys Thr Met Phe Leu Phe Ser Val Phe Phe Thr Met Phe 3245 3250 3255 Trp Ala Glu Leu Phe Ile Tyr Thr Asn Thr Ile Trp Ile Asn Pro 3260 3265 3270 Val Ile Leu Thr Pro Ile Phe Cys Leu Leu Leu Phe Leu Ser Leu 3275 3280 3285 Val Leu Thr Met Phe Leu Lys His Lys Phe Leu Phe Leu Gln Val 3290 3295 3300 Phe Leu Leu Pro Thr Val Ile Ala Thr Ala Leu Tyr Asn Cys Val 3305 3310 3315 Leu Asp Tyr Tyr Ile Val Lys Phe Leu Ala Asp His Phe Asn Tyr 3320 3325 3330 Asn Val Ser Val Leu Gln Met Asp Val Gln Gly Leu Val Asn Val 3335 3340 3345 Leu Val Cys Leu Phe Val Val Phe Leu His Thr Trp Arg Phe Ser 3350 3355 3360 Lys Glu Arg Phe Thr His Trp Phe Thr Tyr Val Cys Ser Leu Ile 3365 3370 3375 Ala Val Ala Tyr Thr Tyr Phe Tyr Ser Gly Asp Phe Leu Ser Leu 3380 3385 3390 Leu Val Met Phe Leu Cys Ala Ile Ser Ser Asp Trp Tyr Ile Gly 3395 3400 3405 Ala Ile Val Phe Arg Leu Ser Arg Leu Ile Ile Phe Phe Ser Pro 3410 3415 3420 Glu Ser Val Phe Ser Val Phe Gly Asp Val Lys Leu Thr Leu Val 3425 3430 3435 Val Tyr Leu Ile Cys Gly Tyr Leu Val Cys Thr Tyr Trp Gly Ile 3440 3445 3450 Leu Tyr Trp Phe Asn Arg Phe Phe Lys Cys Thr Met Gly Val Tyr 3455 3460 3465 Asp Phe Lys Val Ser Ala Ala Glu Phe Lys Tyr Met Val Ala Asn 3470 3475 3480 Gly Leu His Ala Pro Tyr Gly Pro Phe Asp Ala Leu Trp Leu Ser 3485 3490 3495 Phe Lys Leu Leu Gly Ile Gly Gly Asp Arg Cys Ile Lys Ile Ser 3500 3505 3510 Thr Val Gln Ser Lys Leu Thr Asp Leu Lys Cys Thr Asn Val Val 3515 3520 3525 Leu Leu Gly Cys Leu Ser Ser Met Asn Ile Ala Ala Asn Ser Ser 3530 3535 3540 Glu Trp Ala Tyr Cys Val Asp Leu His Asn Lys Ile Asn Leu Cys 3545 3550 3555 Asp Asp Pro Glu Lys Ala Gln Gly Met Leu Leu Ala Leu Leu Ala 3560 3565 3570 Phe Phe Leu Ser Lys His Ser Asp Phe Gly Leu Asp Gly Leu Ile 3575 3580 3585 Asp Ser Tyr Phe Asp Asn Ser Ser Thr Leu Gln Ser Val Ala Ser 3590 3595 3600 Ser Phe Val Ser Met Pro Ser Tyr Ile Ala Tyr Glu Asn Ala Arg 3605 3610 3615 Gln Ala Tyr Glu Asp Ala Ile Ala Asn Gly Ser Ser Ser Gln Leu 3620 3625 3630 Ile Lys Gln Leu Lys Arg Ala Met Asn Ile Ala Lys Ser Glu Phe 3635 3640 3645 Asp His Glu Ile Ser Val Gln Lys Lys Ile Asn Arg Met Ala Glu 3650 3655 3660 Gln Ala Ala Thr Gln Met Tyr Lys Glu Ala Arg Ser Val Asn Arg 3665 3670 3675 Lys Ser Lys Val Ile Ser Ala Met His Ser Leu Leu Phe Gly Met 3680 3685 3690 Leu Arg Arg Leu Asp Met Ser Ser Val Glu Thr Val Leu Asn Leu 3695 3700 3705 Ala Arg Asp Gly Val Val Pro Leu Ser Val Ile Pro Ala Thr Ser 3710 3715 3720 Ala Ser Lys Leu Thr Ile Val Ser Pro Asp Leu Glu Ser Tyr Ser 3725 3730 3735 Lys Ile Val Cys Asp Gly Ser Val His Tyr Ala Gly Val Val Trp 3740 3745 3750 Thr Leu Asn Asp Val Lys Asp Asn Asp Gly Arg Pro Val His Val 3755 3760 3765 Lys Glu Ile Thr Arg Glu Asn Val Glu Thr Leu Thr Trp Pro Leu 3770 3775 3780 Ile Leu Asn Cys Glu Arg Val Val Lys Leu Gln Asn Asn Glu Ile 3785 3790 3795 Met Pro Gly Lys Leu Lys Gln Lys Pro Met Lys Ala Glu Gly Asp 3800 3805 3810 Gly Gly Val Leu Gly Asp Gly Asn Ala Leu Tyr Asn Thr Glu Gly 3815 3820 3825 Gly Lys Thr Phe Met Tyr Ala Tyr Ile Ser Asn Lys Ala Asp Leu 3830 3835 3840 Lys Phe Val Lys Trp Glu Tyr Glu Gly Gly Cys Asn Thr Ile Glu 3845 3850 3855 Leu Asp Ser Pro Cys Arg Phe Met Val Glu Thr Pro Asn Gly Pro 3860 3865 3870 Gln Val Lys Tyr Leu Tyr Phe Val Lys Asn Leu Asn Thr Leu Arg 3875 3880 3885 Arg Gly Ala Val Leu Gly Phe Ile Gly Ala Thr Ile Arg Leu Gln 3890 3895 3900 Ala Gly Lys Gln Thr Glu Leu Ala Val Asn Ser Gly Leu Leu Thr 3905 3910 3915 Ala Cys Ala Phe Ser Val Asp Pro Ala Thr Thr Tyr Leu Glu Ala 3920 3925 3930 Val Lys His Gly Ala Lys Pro Val Ser Asn Cys Ile Lys Met Leu 3935 3940 3945 Ser Asn Gly Ala Gly Asn Gly Gln Ala Ile Thr Thr Ser Val Asp 3950 3955 3960 Ala Asn Thr Asn Gln Asp Ser Tyr Gly Gly Ala Ser Ile Cys Leu 3965 3970 3975 Tyr Cys Arg Ala His Val Pro His Pro Ser Met Asp Gly Tyr Cys 3980 3985 3990 Lys Phe Lys Gly Lys Cys Val Gln Val Pro Ile Gly Cys Leu Asp 3995 4000 4005 Pro Ile Arg Phe Cys Leu Glu Asn Asn Val Cys Asn Val Cys Gly 4010 4015 4020 Cys Trp Leu Gly His Gly Cys Ala Cys Asp Arg Thr Thr Ile Gln 4025 4030 4035 Ser Val Asp Ile Ser Tyr Leu Asn Glu Gln Gly Val Leu Val Gln 4040 4045 4050 Leu Asp 4055 <210> 3 <211> 1355 <212> PRT <213> EMCR Coronavirus <400> 3 Met Lys Leu Phe Leu Ile Leu Leu Ile Leu Pro Leu Val Ser Cys Phe 1 5 10 15 Ser Thr Cys Asn Ser Asn Ala Ser Ile Ser Met Leu Gln Leu Gly Val 20 25 30 Pro Asp Asn Ser Ser Thr Ile Val Thr Gly Leu Leu Pro Val His Trp 35 40 45 Ile Cys Ala Asn Gln Ser Thr Ser Ser Tyr Pro Ala Asn Gly Phe Phe 50 55 60 Tyr Ile Asp Val Gly Lys His Arg Ser Ala Phe Ala Leu His Ser Gly 65 70 75 80 Tyr Tyr Asp Ala Asn Gln Tyr Tyr Ile Tyr Leu Thr Asn Lys Ile His 85 90 95 Leu Asn Ala Pro Val Thr Leu Lys Ile Cys Lys Phe Gly Asn Thr Ser 100 105 110 Phe Asp Phe Leu Ser Asn Val Ser Thr Ser His Asp Cys Ile Val Asn 115 120 125 Leu Ser Phe Thr Glu Gln Leu Gly Val Pro Leu Gly Ile Thr Ile Ser 130 135 140 Gly Glu Thr Val Arg Leu His Leu Tyr Asn Ala Thr Arg Thr Phe Tyr 145 150 155 160 Val Pro Ala Ala Tyr Lys Leu Thr Lys Leu Ser Val Lys Cys Tyr Phe 165 170 175 Ser Glu Ser Cys Val Phe Ser Val Val Asn Ala Thr Ile Thr Val Asn 180 185 190 Val Thr Thr Leu Asn Gly Arg Ile Val Asn Tyr Thr Val Cys Asp Asp 195 200 205 Cys Asn Gly Tyr Thr Asp Asn Ile Phe Ser Val Gln Gln Asp Gly Arg 210 215 220 Ile Pro Asn Gly Phe Pro Phe Asn Asn Trp Phe Leu Leu Thr Asn Gly 225 230 235 240 Ser Thr Leu Val Asp Gly Val Ser Arg Leu Tyr Gln Pro Leu Arg Leu 245 250 255 Thr Cys Leu Trp Pro Val Pro Gly Leu Lys Ser Ser Thr Gly Phe Val 260 265 270 Tyr Phe Asn Ala Thr Gly Ser Asp Val Asn Cys Asn Gly Tyr Gln His 275 280 285 Asn Ser Val Ala Asp Val Met Arg Tyr Asn Leu Asn Leu Ser Ala Asn 290 295 300 Ser Val Asp Asn Leu Lys Ser Gly Val Ile Val Phe Lys Thr Leu Gln 305 310 315 320 Tyr Asp Val Leu Phe Tyr Cys Ser Asn Ser Ser Ser Gly Val Leu Asp 325 330 335 Thr Thr Ile Pro Phe Gly Pro Ser Ser Gln Pro Tyr Tyr Cys Phe Ile 340 345 350 Asn Ser Thr Ile Asn Thr Thr His Val Ser Thr Phe Val Gly Ile Leu 355 360 365 Pro Pro Thr Val Arg Glu Ile Val Val Ala Arg Thr Gly Gln Phe Tyr 370 375 380 Ile Asn Gly Phe Lys Tyr Phe Asp Leu Gly Phe Ile Glu Ala Val Asn 385 390 395 400 Phe Asn Val Thr Thr Ala Ser Ala Thr Asp Phe Trp Thr Val Ala Phe 405 410 415 Ala Thr Phe Val Asp Val Leu Val Asn Val Ser Ala Thr Asn Ile Gln 420 425 430 Asn Leu Leu Tyr Cys Asp Ser Pro Phe Glu Lys Leu Gln Cys Glu His 435 440 445 Leu Gln Phe Gly Leu Gln Asp Gly Phe Tyr Ser Ala Asn Phe Leu Asp 450 455 460 Asp Asn Val Leu Pro Glu Thr Tyr Val Ala Leu Pro Ile Tyr Tyr Gln 465 470 475 480 His Thr Asp Ile Asn Phe Thr Ala Thr Ala Ser Phe Gly Gly Ser Cys 485 490 495 Tyr Val Cys Lys Pro Arg Gln Val Asn Ile Ser Leu Asn Gly Asn Thr 500 505 510 Ser Val Cys Val Arg Thr Ser His Phe Ser Ile Arg Tyr Ile Tyr Asn 515 520 525 Arg Val Lys Ser Gly Ser Pro Gly Asp Ser Ser Trp His Ile Tyr Leu 530 535 540 Lys Ser Gly Thr Cys Pro Phe Ser Phe Ser Lys Leu Asn Asn Phe Gln 545 550 555 560 Lys Phe Lys Thr Ile Cys Phe Ser Thr Val Glu Val Pro Gly Ser Cys 565 570 575 Asn Phe Pro Leu Glu Ala Thr Trp His Tyr Thr Ser Tyr Thr Ile Val 580 585 590 Gly Ala Leu Tyr Val Thr Trp Ser Glu Gly Asn Ser Ile Thr Gly Val 595 600 605 Pro Tyr Pro Val Ser Gly Ile Arg Glu Phe Ser Asn Leu Val Leu Asn 610 615 620 Asn Cys Thr Lys Tyr Asn Ile Tyr Asp Tyr Val Gly Thr Gly Ile Ile 625 630 635 640 Arg Ser Ser Asn Gln Ser Leu Ala Gly Gly Ile Thr Tyr Val Ser Asn 645 650 655 Ser Gly Asn Leu Leu Gly Phe Lys Asn Val Ser Thr Gly Asn Ile Phe 660 665 670 Ile Val Thr Pro Cys Asn Gln Pro Asp Gln Val Ala Val Tyr Gln Gln 675 680 685 Ser Ile Ile Gly Ala Met Thr Ala Val Asn Glu Ser Arg Tyr Gly Leu 690 695 700 Gln Asn Leu Leu Gln Leu Pro Asn Phe Tyr Tyr Val Ser Asn Gly Gly 705 710 715 720 Asn Asn Cys Thr Thr Ala Val Met Ile Tyr Ser Asn Phe Gly Ile Cys 725 730 735 Ala Asp Gly Ser Leu Ile Pro Val Arg Pro Arg Asn Ser Ser Asp Asn 740 745 750 Gly Ile Ser Ala Ile Ile Thr Ala Asn Leu Ser Ile Pro Ser Asn Trp 755 760 765 Thr Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro Ile 770 775 780 Val Val Asp Cys Ala Thr Tyr Val Cys Asn Gly Asn Pro Arg Cys Lys 785 790 795 800 Asn Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp Ala 805 810 815 Leu Arg Leu Ser Ala His Leu Glu Thr Asn Asp Val Ser Ser Met Leu 820 825 830 Thr Phe Asp Ser Asn Ala Phe Ser Leu Ala Asn Val Thr Ser Phe Gly 835 840 845 Asp Tyr Asn Leu Ser Ser Val Leu Pro Gln Arg Asn Ile His Ser Ser 850 855 860 Arg Ile Ala Gly Arg Ser Ala Leu Glu Asp Leu Leu Phe Ser Lys Val 865 870 875 880 Val Thr Ser Gly Leu Gly Thr Val Asp Val Asp Tyr Lys Ser Cys Thr 885 890 895 Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn Gly 900 905 910 Ile Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met Tyr 915 920 925 Thr Gly Ser Leu Ile Gly Gly Met Val Leu Gly Gly Leu Thr Ser Ala 930 935 940 Ala Ala Ile Pro Phe Ser Leu Ala Leu Gln Ala Arg Leu Asn Tyr Val 945 950 955 960 Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala Ala 965 970 975 Ser Phe Asn Lys Ala Ile Asn Asn Ile Val Ala Ser Phe Ser Ser Val 980 985 990 Asn Asp Ala Ile Thr His Thr Ala Glu Ala Ile His Thr Val Thr Ile 995 1000 1005 Ala Leu Asn Lys Ile Gln Asp Val Val Asn Gln Gln Gly Ser Ala 1010 1015 1020 Leu Asn His Leu Thr Ser Gln Leu Arg His Asn Phe Gln Ala Ile 1025 1030 1035 Ser Asn Ser Ile His Ala Ile Tyr Asp Arg Leu Asp Ser Ile Gln 1040 1045 1050 Ala Asp Gln Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ala Ala 1055 1060 1065 Leu Asn Ala Phe Val Ser Gln Val Leu Asn Lys Tyr Thr Glu Val 1070 1075 1080 Arg Gly Ser Arg Arg Leu Ala Gln Gln Lys Ile Asn Glu Cys Val 1085 1090 1095 Lys Ser Gln Ser Asn Arg Tyr Gly Phe Cys Gly Asn Gly Thr His 1100 1105 1110 Ile Phe Ser Ile Val Asn Ser Ala Pro Asp Gly Leu Leu Phe Leu 1115 1120 1125 His Thr Val Leu Leu Pro Thr Asp Tyr Lys Asn Val Lys Ala Trp 1130 1135 1140 Ser Gly Ile Cys Val Asp Gly Ile Tyr Gly Tyr Val Leu Arg Gln 1145 1150 1155 Pro Asn Leu Val Leu Tyr Ser Asp Asn Gly Val Phe Arg Val Thr 1160 1165 1170 Ser Arg Val Met Phe Gln Pro Arg Leu Pro Val Leu Ser Asp Phe 1175 1180 1185 Val Gln Ile Tyr Asn Cys Asn Val Thr Phe Val Asn Ile Ser Arg 1190 1195 1200 Val Glu Leu His Thr Val Ile Pro Asp Tyr Val Asp Val Asn Lys 1205 1210 1215 Thr Leu Gln Glu Phe Ala Gln Asn Leu Pro Lys Tyr Val Lys Pro 1220 1225 1230 Asn Phe Asp Leu Thr Pro Phe Asn Leu Thr Tyr Leu Asn Leu Ser 1235 1240 1245 Ser Glu Leu Lys Gln Leu Glu Ala Lys Thr Ala Ser Leu Phe Gln 1250 1255 1260 Thr Thr Val Glu Leu Gln Gly Leu Ile Asp Gln Ile Asn Ser Thr 1265 1270 1275 Tyr Val Asp Leu Lys Leu Leu Asn Arg Phe Glu Asn Tyr Ile Lys 1280 1285 1290 Trp Pro Trp Trp Val Trp Leu Ile Ile Ser Val Val Phe Val Val 1295 1300 1305 Leu Leu Ser Leu Leu Val Phe Cys Cys Leu Ser Thr Gly Cys Cys 1310 1315 1320 Gly Cys Cys Asn Cys Leu Thr Ser Ser Met Arg Gly Cys Cys Asp 1325 1330 1335 Cys Gly Ser Thr Lys Leu Pro Tyr Tyr Glu Phe Glu Lys Val His 1340 1345 1350 Val Gln 1355 <210> 4 <211> 77 <212> PRT <213> EMCR Coronavirus <400> 4 Met Phe Leu Arg Leu Ile Asp Asp Asn Gly Ile Val Leu Asn Ser Ile 1 5 10 15 Leu Trp Leu Leu Val Met Ile Phe Phe Phe Val Leu Ala Met Thr Phe 20 25 30 Ile Lys Leu Ile Gln Leu Cys Phe Thr Cys His Tyr Phe Phe Ser Arg 35 40 45 Thr Leu Tyr Gln Pro Val Tyr Lys Ile Phe Leu Ala Tyr Gln Asp Tyr 50 55 60 Met Gln Ile Ala Pro Val Pro Ala Glu Val Leu Asn Val 65 70 75 <210> 5 <211> 226 <212> PRT <213> EMCR Coronavirus <400> 5 Met Ser Asn Ser Ser Val Pro Leu Ser Glu Val Tyr Val His Leu Arg 1 5 10 15 Asn Trp Asn Phe Ser Trp Asn Leu Ile Leu Thr Val Phe Ile Val Val 20 25 30 Leu Gln Tyr Gly His Tyr Lys Tyr Ser Arg Leu Leu Tyr Gly Leu Lys 35 40 45 Met Ser Val Leu Trp Cys Leu Trp Pro Leu Val Leu Ala Leu Ser Ile 50 55 60 Phe Asp Cys Phe Val Asn Phe Asn Val Asp Trp Val Phe Phe Gly Phe 65 70 75 80 Ser Ile Leu Met Ser Ile Ile Thr Leu Cys Leu Trp Val Met Tyr Phe 85 90 95 Val Asn Ser Phe Arg Leu Trp Arg Arg Val Lys Thr Phe Trp Ala Phe 100 105 110 Asn Pro Glu Thr Asn Ala Ile Ile Ser Leu Gln Val Tyr Gly His Asn 115 120 125 Tyr Tyr Leu Pro Val Met Ala Ala Pro Thr Gly Val Thr Leu Thr Leu 130 135 140 Leu Ser Gly Val Leu Leu Val Asp Gly His Lys Ile Ala Thr Arg Val 145 150 155 160 Gln Val Gly Gln Leu Pro Lys Tyr Val Ile Val Ala Thr Pro Ser Thr 165 170 175 Thr Ile Val Cys Asp Arg Val Gly Arg Ser Val Asn Glu Thr Ser Gln 180 185 190 Thr Gly Trp Ala Phe Tyr Val Arg Ala Lys His Gly Asp Phe Ser Gly 195 200 205 Val Ala Ser Gln Glu Gly Val Leu Ser Glu Arg Glu Lys Leu Leu His 210 215 220 Leu Ile 225 <210> 6 <211> 377 <212> PRT <213> EMCR Coronavirus <400> 6 Met Ala Ser Val Asn Trp Ala Asp Asp Arg Ala Ala Arg Lys Lys Phe 1 5 10 15 Pro Pro Pro Ser Phe Tyr Met Pro Leu Leu Val Ser Ser Asp Lys Ala 20 25 30 Pro Tyr Arg Val Ile Pro Arg Asn Leu Val Pro Ile Gly Lys Gly Asn 35 40 45 Lys Asp Glu Gln Ile Gly Tyr Trp Asn Val Gln Glu Arg Trp Arg Met 50 55 60 Arg Arg Gly Gln Arg Val Asp Leu Pro Pro Lys Val His Phe Tyr Tyr 65 70 75 80 Leu Gly Thr Gly Pro His Lys Asp Leu Lys Phe Arg Gln Arg Ser Asp 85 90 95 Gly Val Val Trp Val Ala Lys Glu Gly Ala Lys Thr Val Asn Thr Ser 100 105 110 Leu Gly Asn Arg Lys Arg Asn Gln Lys Pro Leu Glu Pro Lys Phe Ser 115 120 125 Ile Ala Leu Pro Pro Glu Leu Ser Val Val Glu Phe Glu Asp Arg Ser 130 135 140 Asn Asn Ser Ser Arg Ala Ser Ser Arg Ser Ser Thr Arg Asn Asn Ser 145 150 155 160 Arg Asp Ser Ser Arg Ser Thr Ser Arg Gln Gln Ser Arg Thr Arg Ser 165 170 175 Asp Ser Asn Gln Ser Ser Ser Asp Leu Val Ala Ala Val Thr Leu Ala 180 185 190 Leu Lys Asn Leu Gly Phe Asp Asn Gln Ser Lys Ser Pro Ser Ser Ser 195 200 205 Gly Thr Ser Thr Pro Lys Lys Pro Asn Lys Pro Leu Ser Gln Pro Arg 210 215 220 Ala Asp Lys Pro Ser Gln Leu Lys Lys Pro Arg Trp Lys Arg Val Pro 225 230 235 240 Thr Arg Glu Glu Asn Val Ile Gln Cys Phe Gly Pro Arg Asp Phe Asn 245 250 255 His Asn Met Gly Asp Ser Asp Leu Val Gln Asn Gly Val Asp Ala Lys 260 265 270 Gly Phe Pro Gln Leu Ala Glu Leu Ile Pro Asn Gln Ala Ala Leu Phe 275 280 285 Phe Asp Ser Glu Val Ser Thr Asp Glu Val Gly Asp Asn Val Gln Ile 290 295 300 Thr Tyr Thr Tyr Lys Met Leu Val Ala Lys Asp Asn Lys Asn Leu Pro 305 310 315 320 Lys Phe Ile Glu Gln Ile Ser Ala Phe Thr Lys Pro Ser Ser Ile Lys 325 330 335 Glu Met Gln Ser Gln Ser Ser His Val Ala Gln Asn Thr Val Leu Asn 340 345 350 Ala Ser Ile Pro Glu Ser Lys Pro Leu Ala Asp Asp Asp Ser Ala Ile 355 360 365 Ile Glu Ile Val Asn Glu Val Leu His 370 375 <210> 7 <211> 27530 <212> DNA <213> EMCR Coronavirus <220> <221> CDS <222> (12402)..(20438) <223> Replicase 1b <220> <221> CDS <222> (24502)..(25182) <223> ORF 4ab <400> 7 agatagagaa ttttcttatt tagactttgt gtctactcct ctcaactaaa cgaaattttt 60 ctagtgctgt catttgttat ggcagtccta gtgtaattga aatttcgtca agtttgtaaa 120 ctggttaggc aagtgttgta ttttctgtgt ttaagcactg gtggttctgt ccactagtgc 180 acacattgat acttaagtgg tgttctgtca ctgcttattg tggaagcaac gttctgtcgt 240 tgtggaaacc aataactgct aaccatgttt tacaatcaag tgacacttgc tgttgcaagt 300 gattcggaaa tttcaggttt tggttttgcc attccttctg tagccgttcg cgcttatagc 360 gaagccgctg cacaaggttt tcaggcatgc cgctttgttg cttttggctt acaggattgt 420 gtaaccggta ttaatgatga cgattatgtc attgcattga ctggtactaa tcagctttgt 480 gccaaaattt tacttttttc tgatagacct cttaatttgc gaggttggct cattttttct 540 aacagcaatt atgttcttca ggactttgat gttgtttttg gccatggtgc aggaagtgtg 600 gtttttgtgg ataagtatat gtgtggtttt gatggtaaac ctgtgttacc taaaaacatg 660 tgggaattta gagattactt taatgataat actgatagta ttgttattgg tggtgtcact 720 tatcaattag catgggatgt tatacgtaaa gacctttctt atgaacagca aaatgtttta 780 gctattgaga gcattcatta tcttggcact acaggtcata ctttgaagtc tggttgcaaa 840 ctcattaatg ccaagccgcc taaatattct tctaaggttg ttttgagtgg tgaatggaat 900 gctgtgtata aggcgtttgg ttcaccattt attacaaatg gtatatcatt gctagatata 960 attgttaaac cagttttctt taatgctttt gttaaatgca attgtggttc tgagaattgg 1020 agtgttggtg catgggatgg ttatctatct tcttgttgtg gcacacctgc taagaaactt 1080 tgtgttgttc ctggtaatgt tgttcctggt gatgtgatca tcacctcaac tgatgctggt 1140 tgtggtgtta aatactatgc tggcttagtt gttaaacata ttactaacat tactggtgtg 1200 tctttatggc gtgttacagc tgttcattct gatggaatgt ttgtggcaac atcttcttat 1260 gatgcacttt tgcatagaaa ttcattagac cctttttgct ttgatgttaa cactttactt 1320 tctaatcaat tacgtctagc ttttcttggt gcttctgtta cagaagatgt taaatttgct 1380 gctagcactg gtgttattga cattagtgct ggtatgtttg gtctttacga tgacatattg 1440 acaaacaata aaccttggtt tgtacgcaaa gcttctgggc tttttgatgc aatctgggat 1500 gcttttgttg ccgctattaa gcttgtgcca actactactg gtggtttggt taggtttgtt 1560 aagtctatcg cttcaactgt tttaactgtt tctaatggtg ttattattat gtgtgcagat 1620 gttccagatg cttttcaacc agtttaccgc acatttacac aagctatttg tgctgcattt 1680 gatttttctt tagatgtatt taaaattggt gatgttaaat ttaaacgact tggtgattat 1740 gttcttactg aaaatgctct tgttcgtttg actactgaag ttgttcgtgg tgttcgtgat 1800 gctcgcataa agaaagccat gtttactaaa gtagttgtag gtcctacaac tgaagttaag 1860 ttttctgtta ttgaacttgc cactgttaat ttgcgtcttg ttgattgtgc acctgtagtt 1920 tgccctaaag gtaaaattgt tgttattgct ggacaagctt ttttctatag tggtggtttt 1980 tatcgtttta tggttgattc tacaactgta ttaaatgacc ctgtttttac tggtgagtta 2040 ttttatacta ttaagtttag tggttttaag cttgatggtt ttaaccatca gtttgttaat 2100 gctagttctg ctacagatgc cattattgct gttgagctgt tgttatcgga ttttaaaact 2160 gcagtttttg tgtacacatg tgtggttgat ggttgtagtg tcattgttag acgtgatgct 2220 acattcgcca cacatgtgtg ttttaaggac tgttatagta tttgggagca attctgcatt 2280 gataattgtg gtgagccatg gtttttgact gattataatg ctatcttgca gagtaataac 2340 cctcaatgtg ctattgttca agcatcggag tctaaagttt tgcttgagag gtttttacct 2400 aagtgtcctg aaatactgtt gagtattgat gatggccatt tatggaatct ttttgttgaa 2460 aagtttaatt ttgttacaga ttggttaaaa actcttaagc ttacacttac ttctaatggt 2520 cttttaggta attgtgccaa acgttttaga cgtgttttgg taaaattgct tgatgtctat 2580 aatggttttc ttgaaactgt ctgtagtgtc gtacacactg ctggtgtttg cattaaatat 2640 tatgctgtta atgttccata tgtagttatt agtggttttg taagtcgtgt aattcgtaga 2700 gaaaggtgtg acgtgacttt tccttgtgtt agttgtgtca cttttttcta tgaattttta 2760 gacacgtgtt ttggtgttag taaacctaat gccattgatg ttgaacattt agagcttaaa 2820 gaaactgttt ttgttgaacc taaggatggt ggtcaatttt ttgtttctga tgattatctt 2880 tggtatgttg tagatgacat ttattatcca gcttcatgta atggtgtatt gccagttgct 2940 tttacaaaat tggcaggtgg taaaatatct ttttctgatg atgttatagt tcatgatgtt 3000 gaacctaccc ataaagtcaa gctcatattt gagtttgaag atgatgttgt taccagtctt 3060 tgtaagaaga gttttggtaa gtctattatt tatacaggtg attgggaagg tttacatgaa 3120 gttcttacat ctgcaatgaa tgtcattggg caacatatta agttgccaca attttatatt 3180 tatgatgaag agggtggtta tgatgtttct aaaccagtta tgatttcaca atggcctatt 3240 agtgatgata gtgatggttg tgttgttgaa gcgagcactg attttcatca attagaatct 3300 gttagagaag aggttgatat aattgaacaa ccttttgggg aagttgaaca tgcgctctca 3360 attagacaac ctttttcttt ttcttttaga gatgaattgg gtgttcgtgt tttagatcaa 3420 tctgataata attgttggat tagtaccaca cttatacagt tgcaacttac aaagcttttg 3480 gatgattcta ttgagatgca attgtttaaa gttggtaaag ttgattcaat tgttcaaaag 3540 tgttatgagt tgtctcattt aattagtggt tcacttggtg atagtggtaa acttcttagt 3600 gaacttctta aagataaata tacatgttct ataacttttg agatgtcttg tgattgtggt 3660 aaaaagtttg atgagcaagt tggttgtttg ttttggatta tgccttacac aaaacttttt 3720 caaaaaggtg agtgttgtat ttgtcataaa atgcagactt ataagcttgt tagtatgaaa 3780 ggtactggtg tgtttgtaca ggatccagca cctattgaca ttgatgcttt ccctgttaga 3840 cctatatgtt catctgtata tttaggtgtt aagggttctg gtcattatca aacaaattta 3900 tacagttttg acaaagctat tgatggtttt ggtgtctttg acattaaaaa tagtagtgtt 3960 aatactgttt gttttgttga tgttgatttt catagtgtag aaatagaagc tggtgaagtt 4020 aaaccttttg ctgtatataa aaatgttaaa ttttatttag gtgatatttc acaccttgta 4080 aactgtgttt cttttgactt tgttgtcaat gctgctaatg aaaatctcat gcatggaggc 4140 ggtgtcgcac gtgctattga tattttgact gaaggtcaac ttcagtcatt atctaaagat 4200 tacattagta gtaatggtcc acttaaggtt ggagcaggtg ttatgttgga gtgtgaaaaa 4260 ttcaatgtat ttaatgttgt tggtccgcga actggtaaac atgagcattc attacttgtt 4320 gaagcttata attctatttt atttgaaaat ggtattccac ttatgcctct tcttagttgt 4380 ggtatttttg gtgtaaggat tgaaaattct cttaaagctt tgtttagttg tgacattaat 4440 aaaccattgc aagtttttgt ttattcttca aatgaagaac aagctgttct taagttttta 4500 gatggtttag atttaacacc agtcattgac gatgttgatg ttgttaaacc ttttagagtt 4560 gaaggtaatt tttcattctt tgattgtggt gtcaatgcct tggatggtga tatttactta 4620 ttatttacta actctatttt aatgttggat aaacaaggac aattattgga cacaaaactt 4680 aatggtattt tgcaacaggc agttcttgat tatcttgcta cagttaaaac tgtaccagct 4740 ggtaatttgg ttaaacttgt tgttgagagt tgtaccattt atatgtgtgt tgtaccatcg 4800 ataaatgatc tttcttttga taaaaatctt ggtcgttgtg tgcgtaaact taatagattg 4860 aaaacttgtg ttattgccaa tgttcctgct attgatgttt tgaaaaagct tctttcaagt 4920 ttgactttaa ctgttaaatt tgttgtagag agtaatgtta tggatgttaa cgactgtttt 4980 aagaatgata atgtagtttt gaaaattact gaagatggta ttaatgttaa agatgttgtt 5040 gttgagtctt ctaagtcact tggtaaacaa ttgggtgttg tgagtgatgg tgttgactct 5100 tttgaaggtg ttttacctat taatactgat actgtcttat ctgtagctcc agaagttgac 5160 tgggttgctt tttacggttt tgaaaaggca gcactttttg cttctttgga tgtaaagcca 5220 tatggttacc ctaatgattt tgttggtggt tttagagttc ttgggaccac cgacaataat 5280 tgttgggtta atgcaacttg tataatttta cagtatctta agcctacttt taaatctaag 5340 ggtttaaatg ttctttggaa caaatttgtt acaggtgatg ttggaccttt tgttagtttt 5400 atttatttta taactatgtc ttcaaagggt caaaagggtg atgctgaaga ggcattatct 5460 aaattgtcag agtatttgat tagtgattct attgttactc ttgaacaata ttcaacttgt 5520 gacatttgta aaagtactgt agttgaagtt aaaagtgctg ttgtctgtgc tagtgtgctt 5580 aaagatggtt gtgatgttgg tttttgtcca cacagacata aattgcgttc acgtgttaag 5640 tttgttaatg gacgtgttgt tattaccaat gttggtgaac ctataatttc acaaccttct 5700 aagttgctta atggtattgc ttatacaaca ttttcaggtt cttttgataa cggtcactat 5760 gtagtttatg atgctgctaa taatgctgtc tatgatggtg ctcgtttatt tgcttcagat 5820 ttgtctactt tagctgttac agctattgtt gtagtaggtg gttgtgtaac atctaatgtt 5880 ccaccaattg ttagtgagaa aatttctgtt atggataaac ttgatactgg tgcacaaaaa 5940 tttttccaat ttggtgattt tgttatgaat aacattgttc tgtttttaac ttggttgctt 6000 agtatgttta gtcttttacg tacttctatt atgaagcatg atattaaagt tattgccaag 6060 gctcctaaac gtacaggtgt tattttgaca cgtagtttta agtataacat tagatctgct 6120 ttgtttgttg taaagcagaa gtggtgtgtt attgttactt tgtttaagtt cttattgtta 6180 ttatatgcta tttatgcact tgtttttatg attgtgcaat ttagtccttt taatagtctt 6240 ttatgtggtg acattgtaag tggttatgaa aaatccactt ttaataagga tatttattgt 6300 ggtaattcta tggtttgtaa gatgtgtttg tttagttatc aagagtttaa tgatttggat 6360 catactagtc ttgtttggaa gcacattcgt gatcctatat taatcagttt acaaccattt 6420 gttatacttg ttattttgtt aatttttggt aatatgtatt tgcgttttgg acttttatat 6480 tttgttgcac aatttattag tacttttggt tctttcttag gctttcatca gaaacagtgg 6540 tttttacatt ttgtgccgtt tgatgtttta tgtaatgagt ttttagctac atttattgtc 6600 tgcaaaattg ttttatttgt tagacatatt attgttggct gtaataatgc tgactgtgta 6660 gcttgttcta aaagtgctag acttaaacgt gtaccacttc aaactattat taatggtatg 6720 cataaatcat tctatgttaa tgctaatggt ggtacttgtt tctgtaataa acataacttc 6780 ttttgtgtta attgtgattc ttttgggcct ggtaatactt ttattaatgg tgatattgca 6840 agagagcttg gtaatgttgt taaaacagct gttcaaccca cagctcctgc atatgttatt 6900 attgataagg tagattttgt taatggattt tatcgtcttt atagtggtga cactttttgg 6960 cggtatgact ttgacattac tgaatctaag tatagttgta aagaggttct gaagaattgt 7020 aatgttttag aaaattttat tgtttacaat aatagtggta gtaacattac acagattaaa 7080 aatgcttgtg tttatttttc tcaattgttg tgtgaaccta taaagttggt aaattcagag 7140 ttgttgtcaa ctttatcagt tgattttaat ggtgttttgc ataaggcata tgttgatgtt 7200 ttgtgtaata gtttttttaa ggagctaact gctaacatgt ccatggctga atgtaaagct 7260 acacttggtt tgactgtttc tgatgatgat tttgtttcag ctgttgccaa tgcacatagg 7320 tatgacgttt tgctttcaga tttgtcattt aataattttt ttatttctta tgctaaacct 7380 gaagataagt tgtccgttta tgacattgct tgttgtatgc gtgccggttc taaggttgtt 7440 aaccataatg ttttaatcaa agagtcaata cctattgttt ggggtgtcaa ggactttaat 7500 actctttctc aagaaggtaa gaagtacctt gttaaaacaa ctaaagcaaa gggtttgact 7560 tttttattaa cttttaatga taaccaagca attacacaag ttcctgctac tagtatagtt 7620 gcaaaacagg gtgctggttt taaacgtact tataattttc tgtggtatgt atgtttattt 7680 gttgttgcat tgtttattgg tgtctcattt attgattata caaccactgt aactagcttt 7740 catggttatg attttaagta cattgagaat ggtcagttga aggtgtttga agcaccttta 7800 cactgtgttc gtaatgtttt tgataatttt aatcaatggc atgaggctaa gtttggtgtt 7860 gttactacta atagtgataa atgtcctata gttgttggtg tttcagagcg tattaatgtt 7920 gttcctggtg ttccaacaaa tgtatatttg gtaggaaaga ctcttgtttt tacattacag 7980 gctgcttttg gaaacacagg tgtttgttat gactttgatg gtgttaccac tagtgataag 8040 tgtattttta attctgcttg tactaggttg gaaggtttgg gtggtgacaa tgtttattgt 8100 tacaacactg atcttattga aggttctaaa ccttatagta ttttacagcc caatgcttat 8160 tataagtatg atgttaaaaa ttatgtacgt tttccagaaa ttttagctag aggttttggc 8220 ttacgtacta ttagaacttt ggctacacgt tattgtagag ttggtgaatg ccgtgactca 8280 cataaaggtg tttgttttgg ttttgataaa tggtatgtta atgatggacg tgttgatgac 8340 ggttacattt gtggtgatgg tcttatagac cttcttgtta atgtactctc aatctttagt 8400 tcatctttta gcgttgtggc tatgtctgga catatgttgt ttaattttct ttttgcagca 8460 tttattacat ttttgtgctt tttagttact aaatttaaac gtgtttttgg tgatctttct 8520 tatggtgttt ttactgttgt ttgtgcaact ttgattaata acatttctta tgttgttact 8580 caaaatttat tttttatgtt gctttatgct attttgtatt ttgtttttac taggacagtg 8640 cgttatgctt ggatttggca tattgcatac attgttgcat acttcttgtt aataccatgg 8700 tggcttctca catggtttag ttttgctgca tttttagagc ttttacctaa tgtttttaag 8760 ttaaaaatct ctactcaatt gtttgaaggt gataagttta taggtacttt tgagagtgct 8820 gctgcaggta catttgttct tgacatgcgt tcttatgaaa ggctgataaa tactatttca 8880 cctgagaaac ttaagaatta tgctgcaagt tataataaat ataaatatta tagtggtagt 8940 gctagtgagg ctgattatcg ttgtgcttgt tatgctcatt tagccaaggc tatgttagat 9000 tacgcaaaag atcataatga catgttatat tctccaccta ccattagcta caattccacc 9060 ttacaatctg gtcttaagaa gatggcacaa ccatctggtt gtgttgagag atgtgtggtt 9120 cgcgtctgtt atggtagtac tgtgcttaat ggagtttggt taggtgacac tgttacttgt 9180 cctagacatg tcatagcacc atcaaccact gttcttattg attatgatca tgcatatagt 9240 actatgcgtt tgcataattt ttcagtgtct cataatggtg tcttcttggg agttgttggt 9300 gttacaatgc atggttctgt gttgcgtatt aaggtttcac aatctaatgt acatacacct 9360 aaacatgttt ttaaaacgtt gaaacctggt gcttctttta atattttagc atgttatgaa 9420 ggtattgcat ctggtgtttt tggtgttaat ttacgtacaa actttactat taaaggttct 9480 tttataaatg gagcttgtgg ttctcctggt tataatgtta gaaatgatgg tactgttgag 9540 ttttgttatt tacaccaaat tgagttaggt agtggtgctc atgttggttc tgattttact 9600 ggtagtgttt atggtaattt tgatgaccaa cctagtttgc aagttgagag tgccaacctt 9660 atgctatcag ataatgttgt tgcctttttg tatgctgctt tgttgaatgg ttgtaggtgg 9720 tggttgcgtt caactagagt taatgttgat ggttttaatg aatgggctat ggctaatggt 9780 tatacaattg tttctagtgt tgagtgctat tctattttgg cagcaaaaac tggtgttagt 9840 gttgaacaat tgttagcttc cattcaacat cttcatgaag gttttggtgg taaaaacata 9900 cttggttatt ctagtttatg tgatgagttc acactagctg aagttgtgaa gcagatgtat 9960 ggtgttaact tgcaaagtgg taaggttatt tttggtttaa aaacaatgtt tttatttagc 10020 gttttcttca caatgttttg ggcagaactc tttatttata caaacactat atggataaac 10080 cctgttatac ttacacctat attttgttta cttttgtttt tgtcattagt tttaactatg 10140 tttcttaaac ataagttttt gtttttgcaa gtatttttat tacctactgt tattgcaact 10200 gctttatata attgtgtttt ggattattac atagtaaaat ttttggctga ccattttaac 10260 tataatgttt cagtattaca aatggatgtt cagggtttag ttaatgtttt ggtctgttta 10320 tttgttgtat ttttacacac atggcgtttt tctaaagaac gtttcacaca ttggtttaca 10380 tatgtgtgtt ctcttatagc agttgcttac acttattttt atagtggtga ctttttgagt 10440 ttgcttgtta tgtttttatg tgctatatct agtgattggt acattggtgc cattgttttt 10500 aggttgtcac gtttgattat atttttttca cctgaaagtg tatttagtgt ttttggtgat 10560 gtgaaactca ctttagttgt ttatttaatt tgtggttatt tagtttgtac ttattggggc 10620 attttgtatt ggttcaatag gttttttaaa tgtactatgg gtgtttatga ttttaaggtg 10680 agtgctgctg aatttaaata catggttgct aatggacttc atgcaccata tggacctttt 10740 gatgcacttt ggttatcatt caaattactt ggtattggtg gtgaccgttg tataaaaatt 10800 tcaactgtcc aatccaaact gactgatttg aagtgtacta atgttgtgtt attgggttgt 10860 ttgtctagta tgaacattgc agctaattct agtgaatggg cttattgtgt tgatttacac 10920 aataagatta atctttgtga tgacccagaa aaagctcaag gtatgttgtt agcactcctt 10980 gcgttctttc taagtaaaca tagtgatttt ggtcttgatg gccttattga ttcttatttt 11040 gataatagta gcaccctgca gagtgttgct tcatcatttg ttagtatgcc atcatatatt 11100 gcttatgaaa atgctagaca agcttatgag gatgctattg ctaatggatc ttcttctcaa 11160 cttattaaac aattgaagcg tgccatgaat atcgcaaagt ctgaatttga tcatgagata 11220 tctgttcaga agaaaattaa tagaatggct gaacaagctg ctactcagat gtataaagaa 11280 gcacgctctg ttaatagaaa atctaaagtt attagtgcta tgcactcttt actttttgga 11340 atgttaagac gtttggatat gtctagtgtt gaaactgttt tgaatttagc acgtgatggt 11400 gttgtgccat tgtcagttat acctgcaact tcagcttcca aactaactat tgttagtcca 11460 gatcttgaat cttattctaa gattgtttgt gatggttctg ttcattatgc tggagttgtt 11520 tggacactta atgatgttaa agacaatgat ggtagacctg ttcatgttaa agagattaca 11580 agggagaatg ttgaaacttt gacatggcct cttatcctta attgtgaacg tgttgttaaa 11640 cttcaaaata atgaaattat gcctggtaaa cttaagcaaa aacctatgaa agctgagggt 11700 gatggtggtg ttttaggtga tggtaatgct ttgtataata ctgagggtgg taaaactttt 11760 atgtatgctt atatttctaa taaagctgac cttaaatttg ttaagtggga gtatgagggt 11820 ggttgcaaca caatcgagtt agactctcct tgtcgattta tggtcgaaac acctaatggt 11880 cctcaagtga agtatttgta ttttgttaaa aatttaaata ccttacgtag aggtgccgtt 11940 cttggtttta taggtgccac aattcgtcta caagctggta aacaaactga attggctgtt 12000 aattctggac ttttaactgc ttgtgctttt tctgttgatc cagcaaccac ttacttggaa 12060 gctgttaaac atggtgcaaa acctgtaagt aattgtatta agatgttatc taatggtgct 12120 ggtaatggtc aagctataac aactagtgta gatgctaaca ccaatcaaga ttcttatggt 12180 ggagcgtcta tttgtttgta ttgtcgggcc cacgttcctc accctagtat ggatggttac 12240 tgtaagttta agggtaaatg tgttcaggtt cctattggtt gtttggatcc tattaggttt 12300 tgtttagaaa ataatgtgtg taatgtttgt ggttgttggt tgggacacgg gtgtgcttgt 12360 gatcgtacaa ccattcaaag tgttgacatt tcttatttaa a cga gca agg ggt tct 12416 Arg Ala Arg Gly Ser 1 5 agt gca gct cga cta gaa ccc tgt aat ggc acg gac atc gat aag tgt 12464 Ser Ala Ala Arg Leu Glu Pro Cys Asn Gly Thr Asp Ile Asp Lys Cys 10 15 20 gtt cgt gct ttt gac att tat aat aaa aat gtt tca ttc ttg ggt aag 12512 Val Arg Ala Phe Asp Ile Tyr Asn Lys Asn Val Ser Phe Leu Gly Lys 25 30 35 tgt ttg aag atg aac tgt gtt cgt ttt aaa aat gct gat ctt aag gat 12560 Cys Leu Lys Met Asn Cys Val Arg Phe Lys Asn Ala Asp Leu Lys Asp 40 45 50 ggt tat ttt gtt ata aag agg tgt act aag tcg gtt atg gaa cac gag 12608 Gly Tyr Phe Val Ile Lys Arg Cys Thr Lys Ser Val Met Glu His Glu 55 60 65 caa tcc atg tat aac cta ctt aac ttt tct ggt gct ttg gct gag cat 12656 Gln Ser Met Tyr Asn Leu Leu Asn Phe Ser Gly Ala Leu Ala Glu His 70 75 80 85 gat ttc ttt act tgg aaa gat ggc aga gtc att tat ggt aat gtt agt 12704 Asp Phe Phe Thr Trp Lys Asp Gly Arg Val Ile Tyr Gly Asn Val Ser 90 95 100 aga cat aat ctt act aaa tat act atg atg gac ttg gtt tat gct atg 12752 Arg His Asn Leu Thr Lys Tyr Thr Met Met Asp Leu Val Tyr Ala Met 105 110 115 cgt aac ttt gat gaa caa aat tgt gat gtt cta aaa gaa gta tta gtt 12800 Arg Asn Phe Asp Glu Gln Asn Cys Asp Val Leu Lys Glu Val Leu Val 120 125 130 tta act ggt tgt tgt gac aat tct tat ttt gat agt aag ggt tgg tat 12848 Leu Thr Gly Cys Cys Asp Asn Ser Tyr Phe Asp Ser Lys Gly Trp Tyr 135 140 145 gac cca gtt gaa aat gaa gat ata cat aga gtt tat gca tct ctt ggc 12896 Asp Pro Val Glu Asn Glu Asp Ile His Arg Val Tyr Ala Ser Leu Gly 150 155 160 165 aaa att gta gct aga gct atg ctt aaa tgc gtt gct cta tgt gat gcg 12944 Lys Ile Val Ala Arg Ala Met Leu Lys Cys Val Ala Leu Cys Asp Ala 170 175 180 atg gtt gct aaa ggt gtt gtt ggt gtt tta aca tta gat aac caa gat 12992 Met Val Ala Lys Gly Val Val Gly Val Leu Thr Leu Asp Asn Gln Asp 185 190 195 ctt aat ggt aac ttt tat gat ttt ggt gat ttt gtt gtt agc tta cct 13040 Leu Asn Gly Asn Phe Tyr Asp Phe Gly Asp Phe Val Val Ser Leu Pro 200 205 210 aat atg ggt gtt ccc tgt tgt aca tca tat tat tct tat atg atg cct 13088 Asn Met Gly Val Pro Cys Cys Thr Ser Tyr Tyr Ser Tyr Met Met Pro 215 220 225 att atg ggt tta act aat tgt tta gct agt gag tgt ttt gtc aag agt 13136 Ile Met Gly Leu Thr Asn Cys Leu Ala Ser Glu Cys Phe Val Lys Ser 230 235 240 245 gat att ttt ggt agt gat ttt aaa act ttt gat ttg ctt aag tat gat 13184 Asp Ile Phe Gly Ser Asp Phe Lys Thr Phe Asp Leu Leu Lys Tyr Asp 250 255 260 ttc act gaa cat aaa gaa aat tta ttc aat aag tac ttt aag cat tgg 13232 Phe Thr Glu His Lys Glu Asn Leu Phe Asn Lys Tyr Phe Lys His Trp 265 270 275 agt ttt gat tat cat cct aat tgt agt gac tgt tat gat gat atg tgt 13280 Ser Phe Asp Tyr His Pro Asn Cys Ser Asp Cys Tyr Asp Asp Met Cys 280 285 290 gtt ata cat tgt gct aat ttt aat aca cta ttt gcc aca act ata cca 13328 Val Ile His Cys Ala Asn Phe Asn Thr Leu Phe Ala Thr Thr Ile Pro 295 300 305 ggt act gct ttt ggt cca cta tgt cgt aaa gtt ttt ata gat ggt gtt 13376 Gly Thr Ala Phe Gly Pro Leu Cys Arg Lys Val Phe Ile Asp Gly Val 310 315 320 325 cca ctt gtt aca act gct ggt tat cat ttt aag caa tta ggt ttg gtt 13424 Pro Leu Val Thr Thr Ala Gly Tyr His Phe Lys Gln Leu Gly Leu Val 330 335 340 tgg aat aaa gat gtt aac aca cac tca gtt agg ttg aca atc act gaa 13472 Trp Asn Lys Asp Val Asn Thr His Ser Val Arg Leu Thr Ile Thr Glu 345 350 355 ctt ttg caa ttt gtt act gac cct tcc ttg ata ata gct tct tct cca 13520 Leu Leu Gln Phe Val Thr Asp Pro Ser Leu Ile Ile Ala Ser Ser Pro 360 365 370 gca ctc gtt gat caa cgc act att tgt ttt tct gtt gca gca ttg agt 13568 Ala Leu Val Asp Gln Arg Thr Ile Cys Phe Ser Val Ala Ala Leu Ser 375 380 385 act ggt ttg aca aat caa gtt gtt aag cca ggt cat ttt aat gaa gag 13616 Thr Gly Leu Thr Asn Gln Val Val Lys Pro Gly His Phe Asn Glu Glu 390 395 400 405 ttt tat aac ttt ctt cgt tta aga ggt ttc ttt gat gaa ggt tct gaa 13664 Phe Tyr Asn Phe Leu Arg Leu Arg Gly Phe Phe Asp Glu Gly Ser Glu 410 415 420 ctt aca tta aaa cat ttc ttc ttc gca cag aat ggt gat gct gct gtt 13712 Leu Thr Leu Lys His Phe Phe Phe Ala Gln Asn Gly Asp Ala Ala Val 425 430 435 aaa gat ttt gac ttt tac cgt tat aat aag cct acc att tta gat att 13760 Lys Asp Phe Asp Phe Tyr Arg Tyr Asn Lys Pro Thr Ile Leu Asp Ile 440 445 450 tgt caa gct aga gtt aca tat aag ata gtc tct cgt tat ttt gac att 13808 Cys Gln Ala Arg Val Thr Tyr Lys Ile Val Ser Arg Tyr Phe Asp Ile 455 460 465 tat gaa ggt ggc tgt att aag gca tgt gaa gtt gtt gta aca aat ctt 13856 Tyr Glu Gly Gly Cys Ile Lys Ala Cys Glu Val Val Val Thr Asn Leu 470 475 480 485 aat aag agt gct ggt tgg cca tta aat aag ttt ggt aaa gct agt ttg 13904 Asn Lys Ser Ala Gly Trp Pro Leu Asn Lys Phe Gly Lys Ala Ser Leu 490 495 500 tat tac gaa tct ata tct tat gaa gaa cag gat gct ttg ttt gct ttg 13952 Tyr Tyr Glu Ser Ile Ser Tyr Glu Glu Gln Asp Ala Leu Phe Ala Leu 505 510 515 aca aag cgt aat gtc ctc cct act atg aca cag ctg aat ctt aag tat 14000 Thr Lys Arg Asn Val Leu Pro Thr Met Thr Gln Leu Asn Leu Lys Tyr 520 525 530 gct att agt ggt aaa gaa cgt gct aga act gtt ggt ggt gtt tct ctg 14048 Ala Ile Ser Gly Lys Glu Arg Ala Arg Thr Val Gly Gly Val Ser Leu 535 540 545 ttg tcc aca atg acc aca aga caa tac cat caa aaa cat ctt aaa tcc 14096 Leu Ser Thr Met Thr Thr Arg Gln Tyr His Gln Lys His Leu Lys Ser 550 555 560 565 att gtt aat aca cgc aat gcc act gtt gtt att ggt act acc aaa ttt 14144 Ile Val Asn Thr Arg Asn Ala Thr Val Val Ile Gly Thr Thr Lys Phe 570 575 580 tat ggt ggt tgg aat aat atg ttg cgt act tta att gat ggt gtt gaa 14192 Tyr Gly Gly Trp Asn Asn Met Leu Arg Thr Leu Ile Asp Gly Val Glu 585 590 595 aac cct atg ctc atg ggt tgg gat tat ccc aaa tgt gat aga gct ttg 14240 Asn Pro Met Leu Met Gly Trp Asp Tyr Pro Lys Cys Asp Arg Ala Leu 600 605 610 cct aac atg ata cgt atg att tca gcc atg gtg ttg ggt tct aag cat 14288 Pro Asn Met Ile Arg Met Ile Ser Ala Met Val Leu Gly Ser Lys His 615 620 625 gtt aat tgt tgt act gta aca gat agg ttt tat agg ctt ggt aac gag 14336 Val Asn Cys Cys Thr Val Thr Asp Arg Phe Tyr Arg Leu Gly Asn Glu 630 635 640 645 ttg gca caa gtt tta aca gaa gtt gtt tat tct aat ggt ggt ttt tat 14384 Leu Ala Gln Val Leu Thr Glu Val Val Tyr Ser Asn Gly Gly Phe Tyr 650 655 660 ttt aag cca ggt ggt acg act tct ggt gac gct agt aca gct tat gct 14432 Phe Lys Pro Gly Gly Thr Thr Ser Gly Asp Ala Ser Thr Ala Tyr Ala 665 670 675 aat tct att ttt aac att ttt caa gcc gtg agt tct aac att aac agg 14480 Asn Ser Ile Phe Asn Ile Phe Gln Ala Val Ser Ser Asn Ile Asn Arg 680 685 690 ttg ctt agt gtc cca tca gat tca tgt aat aat gtt aat gtt agg gat 14528 Leu Leu Ser Val Pro Ser Asp Ser Cys Asn Asn Val Asn Val Arg Asp 695 700 705 cta caa cga cgt ctg tat gat aat tgc tat agg tta act agt gtt gaa 14576 Leu Gln Arg Arg Leu Tyr Asp Asn Cys Tyr Arg Leu Thr Ser Val Glu 710 715 720 725 gag tca ttc att gat gat tat tat ggt tat ctt agg aaa cat ttt tca 14624 Glu Ser Phe Ile Asp Asp Tyr Tyr Gly Tyr Leu Arg Lys His Phe Ser 730 735 740 atg atg att ctc tct gat gac ggt gtt gtc tgt tat aac aag gat tat 14672 Met Met Ile Leu Ser Asp Asp Gly Val Val Cys Tyr Asn Lys Asp Tyr 745 750 755 gct gag tta ggt tat ata gca gac att agt gct ttt aaa gcc act ttg 14720 Ala Glu Leu Gly Tyr Ile Ala Asp Ile Ser Ala Phe Lys Ala Thr Leu 760 765 770 tat tac cag aat aat gtc ttt atg agt act tct aaa tgt tgg gtt gaa 14768 Tyr Tyr Gln Asn Asn Val Phe Met Ser Thr Ser Lys Cys Trp Val Glu 775 780 785 gaa gat tta act aag gga cca cat gag ttt tgt tcc cag cat act atg 14816 Glu Asp Leu Thr Lys Gly Pro His Glu Phe Cys Ser Gln His Thr Met 790 795 800 805 caa ata gtt gat aaa gat ggt acc tat tat ttg cct tac cca gat cct 14864 Gln Ile Val Asp Lys Asp Gly Thr Tyr Tyr Leu Pro Tyr Pro Asp Pro 810 815 820 agt agg atc ttg tca gct ggt gtt ttt gtt gat gat gtt gtt aag aca 14912 Ser Arg Ile Leu Ser Ala Gly Val Phe Val Asp Asp Val Val Lys Thr 825 830 835 gat gct gtt gtt ttg tta kaa cgt tat gtg tct tta gct att gat gca 14960 Asp Ala Val Val Leu Leu Xaa Arg Tyr Val Ser Leu Ala Ile Asp Ala 840 845 850 tac cct ctt tca aaa cac cct aat tct gaa tat cgt aag gtt ttt tac 15008 Tyr Pro Leu Ser Lys His Pro Asn Ser Glu Tyr Arg Lys Val Phe Tyr 855 860 865 gta tta ctt gat tgg gtt aag cat ctt aac aaa aat ttg aat gag ggt 15056 Val Leu Leu Asp Trp Val Lys His Leu Asn Lys Asn Leu Asn Glu Gly 870 875 880 885 gtt ctt gaa tct ttt tct gtt aca ctt ctt gat aat caa gaa gat aag 15104 Val Leu Glu Ser Phe Ser Val Thr Leu Leu Asp Asn Gln Glu Asp Lys 890 895 900 ttt tgg tgt gaa gat ttt tat gct agt atg tat gaa aat tct aca ata 15152 Phe Trp Cys Glu Asp Phe Tyr Ala Ser Met Tyr Glu Asn Ser Thr Ile 905 910 915 ttg caa gct gct ggc tta tgt gtt gtt tgt ggt tca caa act gtt ctt 15200 Leu Gln Ala Ala Gly Leu Cys Val Val Cys Gly Ser Gln Thr Val Leu 920 925 930 cgt tgt ggt gat tgt ctg cgt aag cct atg ttg tgc act aaa tgt gca 15248 Arg Cys Gly Asp Cys Leu Arg Lys Pro Met Leu Cys Thr Lys Cys Ala 935 940 945 tat gat cat gta ttt ggt acc gac cac aag ttt att ttg gct ata aca 15296 Tyr Asp His Val Phe Gly Thr Asp His Lys Phe Ile Leu Ala Ile Thr 950 955 960 965 ccg tat gta tgt aat gca tca ggt tgt ggt gtt agt gat gtt aaa aaa 15344 Pro Tyr Val Cys Asn Ala Ser Gly Cys Gly Val Ser Asp Val Lys Lys 970 975 980 ttg tat ctt ggt ggt ttg aat tac tat tgt aca aat cat aaa cca cag 15392 Leu Tyr Leu Gly Gly Leu Asn Tyr Tyr Cys Thr Asn His Lys Pro Gln 985 990 995 ttg tct ttt cca tta tgt tct gct ggt aat ata ttt ggt tta tat 15437 Leu Ser Phe Pro Leu Cys Ser Ala Gly Asn Ile Phe Gly Leu Tyr 1000 1005 1010 aaa aat tca gca act ggt tcc tta gat gtt gaa gtt ttt aat agg 15482 Lys Asn Ser Ala Thr Gly Ser Leu Asp Val Glu Val Phe Asn Arg 1015 1020 1025 ctt gca acg tct gat tgg act gat gtt agg gac tat aaa ctt gct 15527 Leu Ala Thr Ser Asp Trp Thr Asp Val Arg Asp Tyr Lys Leu Ala 1030 1035 1040 aat gat gtt aaa gat aca ctt aga ctc ttt gcg gct gaa act att 15572 Asn Asp Val Lys Asp Thr Leu Arg Leu Phe Ala Ala Glu Thr Ile 1045 1050 1055 aaa gct aaa gaa gag agt gtt aag tct tct tat gct ttt gca act 15617 Lys Ala Lys Glu Glu Ser Val Lys Ser Ser Tyr Ala Phe Ala Thr 1060 1065 1070 ctt aaa gag gtt gtt gga cct aaa gaa ttg ctt ctt agt tgg gaa 15662 Leu Lys Glu Val Val Gly Pro Lys Glu Leu Leu Leu Ser Trp Glu 1075 1080 1085 agt ggt aaa gtt aaa cca cct ttg aat cgt aat tct gtt ttc acc 15707 Ser Gly Lys Val Lys Pro Pro Leu Asn Arg Asn Ser Val Phe Thr 1090 1095 1100 tgt ttt caa ata agt aag gac tca aaa ttc caa ata ggt gag ttc 15752 Cys Phe Gln Ile Ser Lys Asp Ser Lys Phe Gln Ile Gly Glu Phe 1105 1110 1115 atc ttt gaa aag gtt gaa tat ggt tct gat act gtt acg tat aag 15797 Ile Phe Glu Lys Val Glu Tyr Gly Ser Asp Thr Val Thr Tyr Lys 1120 1125 1130 tct act gta acc act aag tta gtt cct ggt atg att ttt gtc tta 15842 Ser Thr Val Thr Thr Lys Leu Val Pro Gly Met Ile Phe Val Leu 1135 1140 1145 aca tct cac aat gtt caa cct tta cgt gca cca act att gca aac 15887 Thr Ser His Asn Val Gln Pro Leu Arg Ala Pro Thr Ile Ala Asn 1150 1155 1160 caa gag aag tat tct agc att tat aaa ttg cac cct gct ttt aat 15932 Gln Glu Lys Tyr Ser Ser Ile Tyr Lys Leu His Pro Ala Phe Asn 1165 1170 1175 gtc agt gat gca tat gct aat ttg gtt cca tat tac caa ctt att 15977 Val Ser Asp Ala Tyr Ala Asn Leu Val Pro Tyr Tyr Gln Leu Ile 1180 1185 1190 ggt aaa caa aag ata act aca ata cag ggt cct cct ggt agt ggt 16022 Gly Lys Gln Lys Ile Thr Thr Ile Gln Gly Pro Pro Gly Ser Gly 1195 1200 1205 aag tca cat tgt tcc att gga ctt gga ttg tac tat cca ggt gcg 16067 Lys Ser His Cys Ser Ile Gly Leu Gly Leu Tyr Tyr Pro Gly Ala 1210 1215 1220 cgt att gtt ttt gtt gct tgt gcc cat gct gct gtt gat tcc tta 16112 Arg Ile Val Phe Val Ala Cys Ala His Ala Ala Val Asp Ser Leu 1225 1230 1235 tgt gca aaa gct atg act gtt tat agc att gat aag tgt act agg 16157 Cys Ala Lys Ala Met Thr Val Tyr Ser Ile Asp Lys Cys Thr Arg 1240 1245 1250 att ata cct gca aga gct cgg gtt gag tgt tat agt ggc ttt aaa 16202 Ile Ile Pro Ala Arg Ala Arg Val Glu Cys Tyr Ser Gly Phe Lys 1255 1260 1265 cca aat aac act agt gca caa tac ata ttt agc act gtt aac gca 16247 Pro Asn Asn Thr Ser Ala Gln Tyr Ile Phe Ser Thr Val Asn Ala 1270 1275 1280 tta cct gag tgt aat gct gat att gtt gtt gta gat gaa gtt tca 16292 Leu Pro Glu Cys Asn Ala Asp Ile Val Val Val Asp Glu Val Ser 1285 1290 1295 atg tgt aca aat tat gac ctt tct gtt att aat cag cgt tta tca 16337 Met Cys Thr Asn Tyr Asp Leu Ser Val Ile Asn Gln Arg Leu Ser 1300 1305 1310 tat aaa cat att gtt tat gtt ggt gat cca caa caa ctt cct gca 16382 Tyr Lys His Ile Val Tyr Val Gly Asp Pro Gln Gln Leu Pro Ala 1315 1320 1325 cct aga gta atg att act aaa ggt gtt atg gag cct gtt gat tat 16427 Pro Arg Val Met Ile Thr Lys Gly Val Met Glu Pro Val Asp Tyr 1330 1335 1340 aac gtt gtt act caa cgt atg tgt gct ata ggc cct gat gtt ttt 16472 Asn Val Val Thr Gln Arg Met Cys Ala Ile Gly Pro Asp Val Phe 1345 1350 1355 ctt cat aaa tgt tat aga tgt cct gct gaa ata gtt aat aca gtt 16517 Leu His Lys Cys Tyr Arg Cys Pro Ala Glu Ile Val Asn Thr Val 1360 1365 1370 tct gaa ctt gtt tat gag aac aag ttt gtc cct gtt aaa cct gct 16562 Ser Glu Leu Val Tyr Glu Asn Lys Phe Val Pro Val Lys Pro Ala 1375 1380 1385 agt aaa cag tgt ttt aaa atc ttt ttt aag ggt aat gta cag gtt 16607 Ser Lys Gln Cys Phe Lys Ile Phe Phe Lys Gly Asn Val Gln Val 1390 1395 1400 gac aat ggc tct agt att aac aga aag cag ctt gaa ata gtt aag 16652 Asp Asn Gly Ser Ser Ile Asn Arg Lys Gln Leu Glu Ile Val Lys 1405 1410 1415 ctg ttt tta gtt aaa aat cca agt tgg agt aag gct gtg ttt att 16697 Leu Phe Leu Val Lys Asn Pro Ser Trp Ser Lys Ala Val Phe Ile 1420 1425 1430 tct cct tat aat agt cag aat tat gtt gct agt aga ttt tta gga 16742 Ser Pro Tyr Asn Ser Gln Asn Tyr Val Ala Ser Arg Phe Leu Gly 1435 1440 1445 ctt caa att caa act gtt gat tct tct caa ggt agt gag tat gat 16787 Leu Gln Ile Gln Thr Val Asp Ser Ser Gln Gly Ser Glu Tyr Asp 1450 1455 1460 tat gta atc tat gca caa act tct gac act gca cat gct tgc aat 16832 Tyr Val Ile Tyr Ala Gln Thr Ser Asp Thr Ala His Ala Cys Asn 1465 1470 1475 gta aac cgt ttt aat gtt gct ata aca cgt gct aag aag ggt ata 16877 Val Asn Arg Phe Asn Val Ala Ile Thr Arg Ala Lys Lys Gly Ile 1480 1485 1490 ttt tgt gta atg tgt gat aaa act ttg ttt gat tca ctt aag ttt 16922 Phe Cys Val Met Cys Asp Lys Thr Leu Phe Asp Ser Leu Lys Phe 1495 1500 1505 ttt gag att aaa cat gca gat tta cac tct agc cag gtt tgt ggc 16967 Phe Glu Ile Lys His Ala Asp Leu His Ser Ser Gln Val Cys Gly 1510 1515 1520 ttg ttt aaa aat tgt aca cgc act cct ctt aat tta cca cca act 17012 Leu Phe Lys Asn Cys Thr Arg Thr Pro Leu Asn Leu Pro Pro Thr 1525 1530 1535 cat gca cac act ttc ttg tcg ttg tca gat cag ttt aag act aca 17057 His Ala His Thr Phe Leu Ser Leu Ser Asp Gln Phe Lys Thr Thr 1540 1545 1550 ggt gat tta gct gtt caa ata ggt tca aat aat gtt tgt act tat 17102 Gly Asp Leu Ala Val Gln Ile Gly Ser Asn Asn Val Cys Thr Tyr 1555 1560 1565 gaa cat gtt ata tca ttt atg ggt ttt agg ttt gat att agt att 17147 Glu His Val Ile Ser Phe Met Gly Phe Arg Phe Asp Ile Ser Ile 1570 1575 1580 cct ggt agt cat agt ttg ttt tgt aca cgt gac ttt gct att cgt 17192 Pro Gly Ser His Ser Leu Phe Cys Thr Arg Asp Phe Ala Ile Arg 1585 1590 1595 aat gtg cgt ggt tgg ttg ggt atg gat gtt gaa agt gct cat gtt 17237 Asn Val Arg Gly Trp Leu Gly Met Asp Val Glu Ser Ala His Val 1600 1605 1610 tgt ggc gat aac ata ggt act aat gtt cct tta cag gtt ggt ttt 17282 Cys Gly Asp Asn Ile Gly Thr Asn Val Pro Leu Gln Val Gly Phe 1615 1620 1625 tca aat ggt gtt aat ttt gtt gtg caa act gaa ggt tgt gtg tct 17327 Ser Asn Gly Val Asn Phe Val Val Gln Thr Glu Gly Cys Val Ser 1630 1635 1640 acc aat ttt ggt gat gtt att aaa cct gtt tgt gca aaa tct cca 17372 Thr Asn Phe Gly Asp Val Ile Lys Pro Val Cys Ala Lys Ser Pro 1645 1650 1655 cca ggt gaa caa ttt aga cac ctt gtt cct ttt tta cgt aaa gga 17417 Pro Gly Glu Gln Phe Arg His Leu Val Pro Phe Leu Arg Lys Gly 1660 1665 1670 caa cct tgg tta att gtt cgt aga cgc att gtg caa atg ata tct 17462 Gln Pro Trp Leu Ile Val Arg Arg Arg Ile Val Gln Met Ile Ser 1675 1680 1685 gat tat ttg tcc aat ttg tct gac att ctt gtc ttt gtt ttg tgg 17507 Asp Tyr Leu Ser Asn Leu Ser Asp Ile Leu Val Phe Val Leu Trp 1690 1695 1700 gca ggt agt ttg gaa tta act aca atg cgt tac ttt gta aaa ata 17552 Ala Gly Ser Leu Glu Leu Thr Thr Met Arg Tyr Phe Val Lys Ile 1705 1710 1715 ggg cca att aaa tat tgt tat tgt ggt aat tct gcc act tgt tat 17597 Gly Pro Ile Lys Tyr Cys Tyr Cys Gly Asn Ser Ala Thr Cys Tyr 1720 1725 1730 aat tca gtt agt aat gaa tat tgt tgt ttt aaa cat gca ttg ggt 17642 Asn Ser Val Ser Asn Glu Tyr Cys Cys Phe Lys His Ala Leu Gly 1735 1740 1745 tgt gat tat gtt tac aat ccg tat gct ttt gat ata caa cag tgg 17687 Cys Asp Tyr Val Tyr Asn Pro Tyr Ala Phe Asp Ile Gln Gln Trp 1750 1755 1760 ggt tat gtt ggt tcc ttg agc cag aac cac cac acg ttc tgt aac 17732 Gly Tyr Val Gly Ser Leu Ser Gln Asn His His Thr Phe Cys Asn 1765 1770 1775 att cat aga aac gag cat gat gct tct ggt gat gct gtt atg aca 17777 Ile His Arg Asn Glu His Asp Ala Ser Gly Asp Ala Val Met Thr 1780 1785 1790 cgt tgt ttg gca gta cat gat tgt ttt gtc aaa aat gtt gat tgg 17822 Arg Cys Leu Ala Val His Asp Cys Phe Val Lys Asn Val Asp Trp 1795 1800 1805 act gta acg tac ccc ttt att gca aat gag aaa ttt atc aat ggc 17867 Thr Val Thr Tyr Pro Phe Ile Ala Asn Glu Lys Phe Ile Asn Gly 1810 1815 1820 tgt ggg cgt aat gtc cag gga cat gtt gtt cgc gca gcc ttg aaa 17912 Cys Gly Arg Asn Val Gln Gly His Val Val Arg Ala Ala Leu Lys 1825 1830 1835 ttg tat aaa cct agt gtt att cat gat att ggt aat cct aaa ggt 17957 Leu Tyr Lys Pro Ser Val Ile His Asp Ile Gly Asn Pro Lys Gly 1840 1845 1850 gta cgt tgt gct gtt act gat gcc aaa tgg tac tgt tat gac aag 18002 Val Arg Cys Ala Val Thr Asp Ala Lys Trp Tyr Cys Tyr Asp Lys 1855 1860 1865 caa cct gtt aat agt aat gtc aag ttg ttg gat tat gat tat gca 18047 Gln Pro Val Asn Ser Asn Val Lys Leu Leu Asp Tyr Asp Tyr Ala 1870 1875 1880 acc cat ggt caa ctt gat ggt ctt tgt tta ttc tgg aat tgt aat 18092 Thr His Gly Gln Leu Asp Gly Leu Cys Leu Phe Trp Asn Cys Asn 1885 1890 1895 gtt gat atg tat cca gaa ttt tca att gtg tgt cgc ttt gac aca 18137 Val Asp Met Tyr Pro Glu Phe Ser Ile Val Cys Arg Phe Asp Thr 1900 1905 1910 cgt act cgt tct gtt ttt aat tta gaa ggt gtt aat ggt ggt tct 18182 Arg Thr Arg Ser Val Phe Asn Leu Glu Gly Val Asn Gly Gly Ser 1915 1920 1925 ctt tat gtt aac aaa cat gcg ttt cat aca cca gca tat gat aaa 18227 Leu Tyr Val Asn Lys His Ala Phe His Thr Pro Ala Tyr Asp Lys 1930 1935 1940 cgt gct ttt gtt aaa tta aaa cct atg ccc ttt ttt tac ttt gat 18272 Arg Ala Phe Val Lys Leu Lys Pro Met Pro Phe Phe Tyr Phe Asp 1945 1950 1955 gac agt gat tgt gat gtt gtg caa gaa caa gtt aat tat gta ccc 18317 Asp Ser Asp Cys Asp Val Val Gln Glu Gln Val Asn Tyr Val Pro 1960 1965 1970 ctt cgc gct agt agt tgt gtt acc cgt tgt aat ata ggt ggt gct 18362 Leu Arg Ala Ser Ser Cys Val Thr Arg Cys Asn Ile Gly Gly Ala 1975 1980 1985 gtt tgt tca aaa cat gca aat ttg tat caa aaa tat gtt gag gca 18407 Val Cys Ser Lys His Ala Asn Leu Tyr Gln Lys Tyr Val Glu Ala 1990 1995 2000 tat aat aca ttt aca cag gct ggt ttt aac att tgg gta cca cat 18452 Tyr Asn Thr Phe Thr Gln Ala Gly Phe Asn Ile Trp Val Pro His 2005 2010 2015 agt ttt gat gtt tat aat ttg tgg caa att ttt att gaa act aat 18497 Ser Phe Asp Val Tyr Asn Leu Trp Gln Ile Phe Ile Glu Thr Asn 2020 2025 2030 tta caa agt ctt gaa aat ata gca ttt aat gtt gta aaa aaa ggg 18542 Leu Gln Ser Leu Glu Asn Ile Ala Phe Asn Val Val Lys Lys Gly 2035 2040 2045 tgt ttt act ggt gtt gat ggt gag tta cct gtt gca gtt gtt aac 18587 Cys Phe Thr Gly Val Asp Gly Glu Leu Pro Val Ala Val Val Asn 2050 2055 2060 gac aaa gtt ttt gtt cgc tat ggc gat gtt gac aac ttg gtt ttt 18632 Asp Lys Val Phe Val Arg Tyr Gly Asp Val Asp Asn Leu Val Phe 2065 2070 2075 aca aat aaa aca aca ttg cct act aat gtt gct ttt gaa ttg ttt 18677 Thr Asn Lys Thr Thr Leu Pro Thr Asn Val Ala Phe Glu Leu Phe 2080 2085 2090 gca aaa cga aaa atg ggt tta aca cca cca ttg tct att ctc aaa 18722 Ala Lys Arg Lys Met Gly Leu Thr Pro Pro Leu Ser Ile Leu Lys 2095 2100 2105 aat ctt ggt gtt gtt gct aca tat aaa ttt gtt tta tgg gat tat 18767 Asn Leu Gly Val Val Ala Thr Tyr Lys Phe Val Leu Trp Asp Tyr 2110 2115 2120 gaa gct gaa aga cct ttt acc tca tat act aag agt gta tgt aaa 18812 Glu Ala Glu Arg Pro Phe Thr Ser Tyr Thr Lys Ser Val Cys Lys 2125 2130 2135 tac act gat ttt aat gag gat gtt tgt gtt tgt ttt gac aat agt 18857 Tyr Thr Asp Phe Asn Glu Asp Val Cys Val Cys Phe Asp Asn Ser 2140 2145 2150 att cag ggt tcg tat gag cgt ttt acg ctt act acg aac gct gtt 18902 Ile Gln Gly Ser Tyr Glu Arg Phe Thr Leu Thr Thr Asn Ala Val 2155 2160 2165 tta ttt tct act gtt gtc att aaa aat tta aca cct ata aag ttg 18947 Leu Phe Ser Thr Val Val Ile Lys Asn Leu Thr Pro Ile Lys Leu 2170 2175 2180 aat ttt ggt atg ttg aat ggt atg cca gtt tct tct att aag agt 18992 Asn Phe Gly Met Leu Asn Gly Met Pro Val Ser Ser Ile Lys Ser 2185 2190 2195 gat aaa ggt gtt gaa aaa tta gtt aat tgg tac aca tat gtt cgt 19037 Asp Lys Gly Val Glu Lys Leu Val Asn Trp Tyr Thr Tyr Val Arg 2200 2205 2210 aaa aat ggt caa ttt caa gat cat tat gat ggt ttt tac act caa 19082 Lys Asn Gly Gln Phe Gln Asp His Tyr Asp Gly Phe Tyr Thr Gln 2215 2220 2225 ggt agg aat tta tca gac ttt aca cca aga agt gat atg gag tat 19127 Gly Arg Asn Leu Ser Asp Phe Thr Pro Arg Ser Asp Met Glu Tyr 2230 2235 2240 gat ttt ctt aac atg gat atg ggt gtt ttt att aat aaa tat ggt 19172 Asp Phe Leu Asn Met Asp Met Gly Val Phe Ile Asn Lys Tyr Gly 2245 2250 2255 ctt gag gat ttt aat ttt gaa cat gtt gta tat ggt gat gtt tca 19217 Leu Glu Asp Phe Asn Phe Glu His Val Val Tyr Gly Asp Val Ser 2260 2265 2270 aaa act aca tta gga ggt ctt cat ttg ttg ata tca cag ttt agg 19262 Lys Thr Thr Leu Gly Gly Leu His Leu Leu Ile Ser Gln Phe Arg 2275 2280 2285 ctt agt aaa atg ggt gtt ttg aaa gct gat gat ttt gtc act gct 19307 Leu Ser Lys Met Gly Val Leu Lys Ala Asp Asp Phe Val Thr Ala 2290 2295 2300 tct gac aca act ttg agg tgc tgt act gtt act tat ctt aat gaa 19352 Ser Asp Thr Thr Leu Arg Cys Cys Thr Val Thr Tyr Leu Asn Glu 2305 2310 2315 ctt agt tca aaa gtt gtt tgt act tat atg gat ttg ttg ttg gac 19397 Leu Ser Ser Lys Val Val Cys Thr Tyr Met Asp Leu Leu Leu Asp 2320 2325 2330 gac ttt gtt act ata cta aag agt tta gat ctt ggt gta ata tct 19442 Asp Phe Val Thr Ile Leu Lys Ser Leu Asp Leu Gly Val Ile Ser 2335 2340 2345 aaa gtt cat gaa gtt att ata gat aat aaa cct tat agg tgg atg 19487 Lys Val His Glu Val Ile Ile Asp Asn Lys Pro Tyr Arg Trp Met 2350 2355 2360 ttg tgg tgt aaa gat aac cac ttg tcc act ttt tat cca cag ttg 19532 Leu Trp Cys Lys Asp Asn His Leu Ser Thr Phe Tyr Pro Gln Leu 2365 2370 2375 cag tct gct gaa tgg aag tgt ggt tat gct atg cca caa att tat 19577 Gln Ser Ala Glu Trp Lys Cys Gly Tyr Ala Met Pro Gln Ile Tyr 2380 2385 2390 aag ctt caa cgt atg tgt ttg gaa cct tgt aat tta tat aat tat 19622 Lys Leu Gln Arg Met Cys Leu Glu Pro Cys Asn Leu Tyr Asn Tyr 2395 2400 2405 ggt gct ggt att aag ttg cct agt ggt ata atg tta aat gtt gtt 19667 Gly Ala Gly Ile Lys Leu Pro Ser Gly Ile Met Leu Asn Val Val 2410 2415 2420 aaa tac act cag ctt tgt caa tac cta aat agc act aca atg tgc 19712 Lys Tyr Thr Gln Leu Cys Gln Tyr Leu Asn Ser Thr Thr Met Cys 2425 2430 2435 gta cct cat aat atg cgt gtt ttg cac tat ggt gct ggt tct gac 19757 Val Pro His Asn Met Arg Val Leu His Tyr Gly Ala Gly Ser Asp 2440 2445 2450 aaa ggt gtg gca cct ggt aca act gtt tta aaa cgt tgg cta cca 19802 Lys Gly Val Ala Pro Gly Thr Thr Val Leu Lys Arg Trp Leu Pro 2455 2460 2465 cct gat gca ata atc att gat aat gat atc aat gat tat gtt agt 19847 Pro Asp Ala Ile Ile Ile Asp Asn Asp Ile Asn Asp Tyr Val Ser 2470 2475 2480 gat gca gat ttt agc att aca ggt gat tgt gct act gtt tac ctt 19892 Asp Ala Asp Phe Ser Ile Thr Gly Asp Cys Ala Thr Val Tyr Leu 2485 2490 2495 gaa gat aag ttt gac tta ctt att tct gat atg tat gat ggt aga 19937 Glu Asp Lys Phe Asp Leu Leu Ile Ser Asp Met Tyr Asp Gly Arg 2500 2505 2510 att aaa ttt tgt gat ggt gaa aac gtc tct aaa gat ggt ttt ttt 19982 Ile Lys Phe Cys Asp Gly Glu Asn Val Ser Lys Asp Gly Phe Phe 2515 2520 2525 act tat ctt aat ggt gtt att aga gaa aaa tta gct att ggt ggt 20027 Thr Tyr Leu Asn Gly Val Ile Arg Glu Lys Leu Ala Ile Gly Gly 2530 2535 2540 agt gtt gcc att aag att aca gaa tat agt tgg aat aag tat ctt 20072 Ser Val Ala Ile Lys Ile Thr Glu Tyr Ser Trp Asn Lys Tyr Leu 2545 2550 2555 tat gaa tta ata caa aga ttt gct ttt tgg act ttg ttc tgc acg 20117 Tyr Glu Leu Ile Gln Arg Phe Ala Phe Trp Thr Leu Phe Cys Thr 2560 2565 2570 tct gtt aat aca tcc tct tca gaa gct ttt ctt att ggt att aat 20162 Ser Val Asn Thr Ser Ser Ser Glu Ala Phe Leu Ile Gly Ile Asn 2575 2580 2585 tat tta ggt gac ttt att caa ggt cct ttt ata gct ggt aac act 20207 Tyr Leu Gly Asp Phe Ile Gln Gly Pro Phe Ile Ala Gly Asn Thr 2590 2595 2600 gtt cat gct aat tat ata ttt tgg cgt aat tct act att atg tct 20252 Val His Ala Asn Tyr Ile Phe Trp Arg Asn Ser Thr Ile Met Ser 2605 2610 2615 ttg tca tac aat tca gtt tta gat tta agt aag ttt gaa tgt aaa 20297 Leu Ser Tyr Asn Ser Val Leu Asp Leu Ser Lys Phe Glu Cys Lys 2620 2625 2630 cat aag gcc act gtt gtt gtt aca ctt aaa gat agt gat gta aat 20342 His Lys Ala Thr Val Val Val Thr Leu Lys Asp Ser Asp Val Asn 2635 2640 2645 gat atg gtt ttg agt ttg att aag agt ggt agg ttg ttg tta cgt 20387 Asp Met Val Leu Ser Leu Ile Lys Ser Gly Arg Leu Leu Leu Arg 2650 2655 2660 aat agt ggc cgt ttt ggt ggt ttt agt aat cat tta gtc tca act 20432 Asn Ser Gly Arg Phe Gly Gly Phe Ser Asn His Leu Val Ser Thr 2665 2670 2675 aaa tga aacttttctt gattttgctt attttgcccc tggtttcttg cttttctaca 20488 Lys tgtaacagta atgctagtat ttctatgtta caattaggtg ttcctgataa ctcttcaact 20548 attgtcacag gtttgttgcc agtccattgg atttgtgcta atcagagtac atctagttac 20608 ccagccaacg gctttttcta tattgatgtt ggtaaacacc gtagtgcctt tgcactccat 20668 agtggttatt atgatgctaa ccagtattat atttatctca ctaataaaat acatttaaat 20728 gctcctgtca ctctgaagat ttgtaagttt ggaaacactt cttttgattt tttaagtaat 20788 gtttctactt ctcatgattg tatagttaat ttgtcattca cagaacagtt aggtgtgcct 20848 ttgggcataa ctatatcggg tgaaactgta cgtttgcatt tatataatgc aactcgtact 20908 ttttatgtgc cggccgctta taaacttact aaacttagtg ttaaatgtta ctttagtgaa 20968 tcctgtgttt ttagtgttgt caatgccacc attactgtta atgtcaccac acttaatggc 21028 cgtatagtta actacactgt ttgtgatgat tgtaatggtt atactgataa catattttct 21088 gttcaacagg atggccgcat tcctaatggt ttccctttta ataattggtt tttgttaact 21148 aatggttcca cattagtgga cggggtctct agactttatc aaccactccg tttaacttgt 21208 ttatggcctg tacctggtct taaatcttca actggttttg tttattttaa tgccactggt 21268 tctgatgtta attgtaacgg ctatcaacat aattctgttg ctgatgttat gcgttacaat 21328 cttaacctca gtgctaattc tgtggacaat cttaagagtg gtgttatagt ttttaaaact 21388 ttacagtacg atgttttgtt ttattgtagt aattcttctt caggtgttct tgacaccaca 21448 ataccttttg gcccttcctc tcaaccttat tactgtttta taaacagtac tatcaacact 21508 actcatgtta gcacttttgt gggtatttta ccacccactg tgcgtgaaat tgttgttgct 21568 agaactggtc agttttatat taatggtttt aagtatttcg atttgggttt catagaagct 21628 gtcaatttta atgtcacgac tgctagtgcc acagattttt ggacggttgc atttgctact 21688 tttgttgatg ttttggttaa tgttagtgca actaacattc aaaacttact ttattgcgat 21748 tctccatttg aaaagttgca gtgtgagcac ttgcagtttg gattgcaaga tggtttttat 21808 tctgcaaatt ttcttgatga taatgttttg cctgagactt atgttgcact ccccatttat 21868 tatcaacata cggacataaa ttttactgca actgcatctt ttggtggttc ttgttatgtt 21928 tgtaaaccac gccaggttaa tatatctctt aatggtaaca cttcagtgtg tgttagaaca 21988 tctcattttt caattaggta tatttataac cgcgttaaga gtggttcacc aggtgactct 22048 tcatggcata tttatttaaa gagtggcact tgtccatttt ctttttctaa gttaaataat 22108 tttcaaaagt ttaagactat ttgtttctca accgtcgaag tgcctggtag ttgtaatttt 22168 ccacttgaag ccacctggca ttacacttct tatactattg ttggtgcttt gtatgttact 22228 tggtctgaag gtaattccat tactggtgta ccttatcctg tctctggtat tcgtgagttt 22288 agtaatttag ttttaaataa ttgtaccaaa tataatattt atgattatgt tggtactgga 22348 attatacgtt cttcaaacca gtcacttgct ggtggtatta catatgtttc taactctggt 22408 aatttacttg gttttaaaaa tgtttccact ggtaacattt ttattgtgac accatgtaac 22468 caaccagatc aagtagctgt ttatcaacaa agcattattg gtgccatgac cgctgttaat 22528 gagtctagat atggcttgca aaacttacta cagttaccta acttttatta tgttagtaat 22588 ggtggtaaca attgcactac ggctgttatg atttattcta attttggtat ttgtgctgat 22648 ggttctttaa ttcctgttcg tccgcgtaat tctagtgata atggtatttc agccataatc 22708 actgctaatt tatccattcc ctctaactgg actacttcag ttcaagttga gtacctccaa 22768 attactagta ctccaatagt tgttgattgt gctacttatg tgtgtaatgg taaccctcgt 22828 tgtaagaatc tacttaagca gtatacttct gcttgtaaaa ctattgaaga tgccttacga 22888 cttagtgctc atttggaaac taatgatgtt agtagtatgc taactttcga tagcaatgct 22948 tttagtttgg ctaatgttac tagttttgga gattataacc tttctagtgt tttacctcag 23008 agaaacattc attcaagccg tatagcagga cgtagtgctt tggaagattt gttgtttagc 23068 aaagttgtta catctggttt gggtactgtt gatgttgact ataagtcttg tactaaaggt 23128 ctttctattg ctgaccttgc ttgtgctcag tactacaatg gcataatggt tttgccaggt 23188 gttgctgatg ctgaacgtat ggccatgtac acaggttctc ttataggtgg catggtgctc 23248 ggaggtctta catcagcagc cgccatacct ttttctttgg cactgcaagc acgacttaac 23308 tatgttgctt tacaaactga tgtgcttcaa gaaaatcaga aaattttggc tgcatcattt 23368 aataaggcta ttaataatat tgttgcttct tttagtagcg ttaatgatgc tattacacat 23428 actgcagagg ctatacatac tgttactatt gcacttaata agattcagga tgttgttaat 23488 caacagggta gtgctcttaa ccatctcact tcacaattga gacataattt tcaggccatt 23548 tctaattcaa ttcatgctat ttatgaccgg cttgattcaa ttcaagccga tcaacaagtt 23608 gacagattaa ttactggacg gcttgcagct ttgaatgcat ttgtttccca agttttgaat 23668 aaatatactg aagttcgtgg ttccagacgc ttagcacagc agaagattaa tgaatgtgtc 23728 aagtcacaat ctaatagata tggtttttgt ggcaatggca ctcacatctt ttcaatcgtc 23788 aactcagctc cagatggttt gctttttctt catactgttt tgctgccaac tgattacaag 23848 aatgtaaagg cgtggtctgg tatctgtgtt gatggcattt atggctatgt tctgcgtcaa 23908 cctaacttgg ttctttattc tgataatggt gtctttcgtg taacttccag ggtcatgttt 23968 caacctcgtt tacctgtttt gtctgatttt gtgcaaatat ataattgtaa tgttactttt 24028 gttaacatat ctcgtgtcga gttacatact gtcatacctg actacgttga tgttaataaa 24088 acattacaag agtttgcaca aaacttacca aagtatgtta agcctaattt tgacttgact 24148 ccttttaatt taacatatct taatttgagt tctgagttga agcaactcga agctaaaact 24208 gctagtcttt tccaaactac tgttgaatta caaggtctta ttgatcagat taacagtaca 24268 tatgttgatt tgaagttgct taataggttt gaaaattata tcaaatggcc ttggtgggtt 24328 tggctcatta tttctgttgt ttttgttgta ttgttgagtc ttcttgtgtt ttgttgtctt 24388 tctacaggtt gttgtggttg ttgcaattgt ttaacttcat caatgcgagg ctgttgtgat 24448 tgtggttcaa ctaaacttcc ttattatgaa tttgaaaagg tccacgttca ata atg 24504 Met cct ttc ggt ggc cta ttt caa ctt act ctt gaa agt act att aat 24549 Pro Phe Gly Gly Leu Phe Gln Leu Thr Leu Glu Ser Thr Ile Asn 2680 2685 2690 aag agt gtg gct aat ctc aaa tta cca cct cat gat gtt act gtc 24594 Lys Ser Val Ala Asn Leu Lys Leu Pro Pro His Asp Val Thr Val 2695 2700 2705 ttg cgt gac aat ctt aaa cct gtt act aca ctt agt act atc act 24639 Leu Arg Asp Asn Leu Lys Pro Val Thr Thr Leu Ser Thr Ile Thr 2710 2715 2720 gct tat ttg tta gtt agt ttg ttt gtc act tat ttt gct tta ttc 24684 Ala Tyr Leu Leu Val Ser Leu Phe Val Thr Tyr Phe Ala Leu Phe 2725 2730 2735 aaa cct ctt act gct aga ggt cgt gtt gct tgt ttt gtt tta aaa 24729 Lys Pro Leu Thr Ala Arg Gly Arg Val Ala Cys Phe Val Leu Lys 2740 2745 2750 cta ttg aca cta tct gtc tat gtg cct tta ttg gtt ctt ttt ggt 24774 Leu Leu Thr Leu Ser Val Tyr Val Pro Leu Leu Val Leu Phe Gly 2755 2760 2765 atg tat ctt gac agt ttt ata att ttt ttt cta cgc tgt tgt ttc 24819 Met Tyr Leu Asp Ser Phe Ile Ile Phe Phe Leu Arg Cys Cys Phe 2770 2775 2780 gat tca tac atg ttg gct att atg cct atc tct aat aaa aat ttt 24864 Asp Ser Tyr Met Leu Ala Ile Met Pro Ile Ser Asn Lys Asn Phe 2785 2790 2795 tca ttt gtt ttg ttc aat gtt act aaa cta tgc ttc gtt tca ggc 24909 Ser Phe Val Leu Phe Asn Val Thr Lys Leu Cys Phe Val Ser Gly 2800 2805 2810 aag tgt tgg tat ctt gaa caa tca ttt tat gaa aat cgt ttt gct 24954 Lys Cys Trp Tyr Leu Glu Gln Ser Phe Tyr Glu Asn Arg Phe Ala 2815 2820 2825 gct att tat ggt ggt gac cac tat gtc gtt tta ggt ggt gaa act 24999 Ala Ile Tyr Gly Gly Asp His Tyr Val Val Leu Gly Gly Glu Thr 2830 2835 2840 att act ttt gtt tct ttt gat gac ctt tat gtt gct att aga ggt 25044 Ile Thr Phe Val Ser Phe Asp Asp Leu Tyr Val Ala Ile Arg Gly 2845 2850 2855 tct tgt gaa aag aac cta caa ctt atg cgt aag gtt gac ttg tat 25089 Ser Cys Glu Lys Asn Leu Gln Leu Met Arg Lys Val Asp Leu Tyr 2860 2865 2870 aat ggt gct gtc att tac att ttt gcc gaa gag cct gtt gtt ggt 25134 Asn Gly Ala Val Ile Tyr Ile Phe Ala Glu Glu Pro Val Val Gly 2875 2880 2885 ata gtt tac tcc tct caa cta tac gaa gat gtt cct tcg att aat 25179 Ile Val Tyr Ser Ser Gln Leu Tyr Glu Asp Val Pro Ser Ile Asn 2890 2895 2900 tga tgacaatggc attgtcctca attctatttt atggctcctt gttatgatat 25232 ttttctttgt gttggcaatg acctttatta aactgattca attgtgtttt acttgtcatt 25292 atttttttag taggacatta tatcaaccag tttataaaat ttttcttgct taccaagatt 25352 atatgcaaat agcacctgtt ccagctgaag tactaaatgt ctaaactaaa cgatgtctaa 25412 tagtagtgtg cctctttcag aggtttatgt ccatttacgt aactggaact ttagttggaa 25472 tttaattcta acagttttta tagttgtgtt gcagtatggg cattataagt atagcagact 25532 tctttatggt ttaaagatgt ctgttttatg gtgtttatgg ccacttgttc tagctttgtc 25592 tatttttgac tgttttgtca attttaatgt ggactgggtc ttttttggtt ttagtattct 25652 tatgtctatt attacacttt gtttatgggt tatgtatttt gttaatagtt tcagactttg 25712 gcgccgtgtt aaaacttttt gggcttttaa tcctgaaact aatgcaatca tctctctcca 25772 ggtttatgga cataattatt acttaccggt gatggctgca cctacaggtg ttacattaac 25832 acttcttagt ggtgtacttc ttgttgatgg ccataagatt gctactcgtg ttcaagtggg 25892 tcagttgcct aaatatgtaa tagttgctac acctagtacc acaattgttt gtgaccgtgt 25952 tggtcgctct gttaatgaaa caagccagac tggttgggca ttctacgtcc gtgctaaaca 26012 tggtgatttt tctggtgttg cctctcagga gggtgttttg tcagaaagag agaagttgct 26072 tcatttaatc taaactaaac aaaatggcta gtgtaaattg ggccgatgac agagctgcta 26132 ggaagaaatt tcctcctcct tcattttaca tgcctctttt ggttagttct gataaggcac 26192 catatagggt cattcccagg aatcttgtcc ctattggtaa gggtaataaa gatgagcaga 26252 ttggttattg gaatgttcaa gagcgttggc gtatgcgcag ggggcaacgt gttgatttgc 26312 ctcctaaagt tcatttttat tacctaggta ctggacctca taaggacctt aaattcagac 26372 aacgttctga tggtgttgtt tgggttgcta aggaaggtgc taaaactgtt aataccagtc 26432 ttggtaatcg caaacgtaat cagaaacctt tggaaccaaa gttctctatt gctttgcctc 26492 cagagctctc tgttgttgag tttgaggatc gctctaataa ctcatctcgt gctagcagtc 26552 gttcttcaac tcgtaacaac tcacgagact cttctcgtag tacttcaaga caacagtctc 26612 gcactcgttc tgattctaac cagtcttctt cagatcttgt tgctgctgtt actttggctt 26672 taaagaactt aggttttgat aaccagtcga agtcacctag ttcttctggt acttccactc 26732 ctaagaaacc taataagcct ctttctcaac ccagggctga taagccttct cagttgaaga 26792 aacctcgttg gaagcgtgtt cctaccagag aggaaaatgt tattcagtgc tttggtcctc 26852 gtgattttaa tcacaatatg ggggattcag atcttgttca gaatggtgtt gatgccaagg 26912 gttttccaca gcttgctgaa ttgattccta atcaggctgc gttattcttt gatagtgagg 26972 ttagcactga tgaagtgggt gataatgttc agattaccta cacctacaaa atgcttgtag 27032 ctaaggataa taagaacctt cctaagttca ttgagcagat tagtgctttt actaaaccca 27092 gttctatcaa agaaatgcag tcacaatcat ctcatgttgc tcagaacaca gtacttaatg 27152 cttctattcc agaatctaaa ccattggctg atgatgattc agccattata gaaattgtca 27212 acgaggtttt gcattaaatt gttttgtaat tccagttgaa tgtttattat tattagttgc 27272 aaccccatgc gtttagcgca tgataagggt ttagtcttac acacaatggt aggccagtga 27332 tagtaaagtg taagtaattt gctatcatat taacatgtct agaggaaagt cagaactttt 27392 tctgtttgtg ttgttggagt acttaaagat cgcataggcg cgccaacaat ggaagagcca 27452 acaacatatc taaaaatgtt ttgtctggta cttgttaatg atattgtttt tgatatggat 27512 acacaaaaaa aaaaaaaa 27530 <210> 8 <211> 2678 <212> PRT <213> EMCR Coronavirus <220> <221> misc_feature <222> (844)..(844) <223> The 'Xaa' at location 844 stands for Glu. <400> 8 Arg Ala Arg Gly Ser Ser Ala Ala Arg Leu Glu Pro Cys Asn Gly Thr 1 5 10 15 Asp Ile Asp Lys Cys Val Arg Ala Phe Asp Ile Tyr Asn Lys Asn Val 20 25 30 Ser Phe Leu Gly Lys Cys Leu Lys Met Asn Cys Val Arg Phe Lys Asn 35 40 45 Ala Asp Leu Lys Asp Gly Tyr Phe Val Ile Lys Arg Cys Thr Lys Ser 50 55 60 Val Met Glu His Glu Gln Ser Met Tyr Asn Leu Leu Asn Phe Ser Gly 65 70 75 80 Ala Leu Ala Glu His Asp Phe Phe Thr Trp Lys Asp Gly Arg Val Ile 85 90 95 Tyr Gly Asn Val Ser Arg His Asn Leu Thr Lys Tyr Thr Met Met Asp 100 105 110 Leu Val Tyr Ala Met Arg Asn Phe Asp Glu Gln Asn Cys Asp Val Leu 115 120 125 Lys Glu Val Leu Val Leu Thr Gly Cys Cys Asp Asn Ser Tyr Phe Asp 130 135 140 Ser Lys Gly Trp Tyr Asp Pro Val Glu Asn Glu Asp Ile His Arg Val 145 150 155 160 Tyr Ala Ser Leu Gly Lys Ile Val Ala Arg Ala Met Leu Lys Cys Val 165 170 175 Ala Leu Cys Asp Ala Met Val Ala Lys Gly Val Val Gly Val Leu Thr 180 185 190 Leu Asp Asn Gln Asp Leu Asn Gly Asn Phe Tyr Asp Phe Gly Asp Phe 195 200 205 Val Val Ser Leu Pro Asn Met Gly Val Pro Cys Cys Thr Ser Tyr Tyr 210 215 220 Ser Tyr Met Met Pro Ile Met Gly Leu Thr Asn Cys Leu Ala Ser Glu 225 230 235 240 Cys Phe Val Lys Ser Asp Ile Phe Gly Ser Asp Phe Lys Thr Phe Asp 245 250 255 Leu Leu Lys Tyr Asp Phe Thr Glu His Lys Glu Asn Leu Phe Asn Lys 260 265 270 Tyr Phe Lys His Trp Ser Phe Asp Tyr His Pro Asn Cys Ser Asp Cys 275 280 285 Tyr Asp Asp Met Cys Val Ile His Cys Ala Asn Phe Asn Thr Leu Phe 290 295 300 Ala Thr Thr Ile Pro Gly Thr Ala Phe Gly Pro Leu Cys Arg Lys Val 305 310 315 320 Phe Ile Asp Gly Val Pro Leu Val Thr Thr Ala Gly Tyr His Phe Lys 325 330 335 Gln Leu Gly Leu Val Trp Asn Lys Asp Val Asn Thr His Ser Val Arg 340 345 350 Leu Thr Ile Thr Glu Leu Leu Gln Phe Val Thr Asp Pro Ser Leu Ile 355 360 365 Ile Ala Ser Ser Pro Ala Leu Val Asp Gln Arg Thr Ile Cys Phe Ser 370 375 380 Val Ala Ala Leu Ser Thr Gly Leu Thr Asn Gln Val Val Lys Pro Gly 385 390 395 400 His Phe Asn Glu Glu Phe Tyr Asn Phe Leu Arg Leu Arg Gly Phe Phe 405 410 415 Asp Glu Gly Ser Glu Leu Thr Leu Lys His Phe Phe Phe Ala Gln Asn 420 425 430 Gly Asp Ala Ala Val Lys Asp Phe Asp Phe Tyr Arg Tyr Asn Lys Pro 435 440 445 Thr Ile Leu Asp Ile Cys Gln Ala Arg Val Thr Tyr Lys Ile Val Ser 450 455 460 Arg Tyr Phe Asp Ile Tyr Glu Gly Gly Cys Ile Lys Ala Cys Glu Val 465 470 475 480 Val Val Thr Asn Leu Asn Lys Ser Ala Gly Trp Pro Leu Asn Lys Phe 485 490 495 Gly Lys Ala Ser Leu Tyr Tyr Glu Ser Ile Ser Tyr Glu Glu Gln Asp 500 505 510 Ala Leu Phe Ala Leu Thr Lys Arg Asn Val Leu Pro Thr Met Thr Gln 515 520 525 Leu Asn Leu Lys Tyr Ala Ile Ser Gly Lys Glu Arg Ala Arg Thr Val 530 535 540 Gly Gly Val Ser Leu Leu Ser Thr Met Thr Thr Arg Gln Tyr His Gln 545 550 555 560 Lys His Leu Lys Ser Ile Val Asn Thr Arg Asn Ala Thr Val Val Ile 565 570 575 Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asn Asn Met Leu Arg Thr Leu 580 585 590 Ile Asp Gly Val Glu Asn Pro Met Leu Met Gly Trp Asp Tyr Pro Lys 595 600 605 Cys Asp Arg Ala Leu Pro Asn Met Ile Arg Met Ile Ser Ala Met Val 610 615 620 Leu Gly Ser Lys His Val Asn Cys Cys Thr Val Thr Asp Arg Phe Tyr 625 630 635 640 Arg Leu Gly Asn Glu Leu Ala Gln Val Leu Thr Glu Val Val Tyr Ser 645 650 655 Asn Gly Gly Phe Tyr Phe Lys Pro Gly Gly Thr Thr Ser Gly Asp Ala 660 665 670 Ser Thr Ala Tyr Ala Asn Ser Ile Phe Asn Ile Phe Gln Ala Val Ser 675 680 685 Ser Asn Ile Asn Arg Leu Leu Ser Val Pro Ser Asp Ser Cys Asn Asn 690 695 700 Val Asn Val Arg Asp Leu Gln Arg Arg Leu Tyr Asp Asn Cys Tyr Arg 705 710 715 720 Leu Thr Ser Val Glu Glu Ser Phe Ile Asp Asp Tyr Tyr Gly Tyr Leu 725 730 735 Arg Lys His Phe Ser Met Met Ile Leu Ser Asp Asp Gly Val Val Cys 740 745 750 Tyr Asn Lys Asp Tyr Ala Glu Leu Gly Tyr Ile Ala Asp Ile Ser Ala 755 760 765 Phe Lys Ala Thr Leu Tyr Tyr Gln Asn Asn Val Phe Met Ser Thr Ser 770 775 780 Lys Cys Trp Val Glu Glu Asp Leu Thr Lys Gly Pro His Glu Phe Cys 785 790 795 800 Ser Gln His Thr Met Gln Ile Val Asp Lys Asp Gly Thr Tyr Tyr Leu 805 810 815 Pro Tyr Pro Asp Pro Ser Arg Ile Leu Ser Ala Gly Val Phe Val Asp 820 825 830 Asp Val Val Lys Thr Asp Ala Val Val Leu Leu Xaa Arg Tyr Val Ser 835 840 845 Leu Ala Ile Asp Ala Tyr Pro Leu Ser Lys His Pro Asn Ser Glu Tyr 850 855 860 Arg Lys Val Phe Tyr Val Leu Leu Asp Trp Val Lys His Leu Asn Lys 865 870 875 880 Asn Leu Asn Glu Gly Val Leu Glu Ser Phe Ser Val Thr Leu Leu Asp 885 890 895 Asn Gln Glu Asp Lys Phe Trp Cys Glu Asp Phe Tyr Ala Ser Met Tyr 900 905 910 Glu Asn Ser Thr Ile Leu Gln Ala Ala Gly Leu Cys Val Val Cys Gly 915 920 925 Ser Gln Thr Val Leu Arg Cys Gly Asp Cys Leu Arg Lys Pro Met Leu 930 935 940 Cys Thr Lys Cys Ala Tyr Asp His Val Phe Gly Thr Asp His Lys Phe 945 950 955 960 Ile Leu Ala Ile Thr Pro Tyr Val Cys Asn Ala Ser Gly Cys Gly Val 965 970 975 Ser Asp Val Lys Lys Leu Tyr Leu Gly Gly Leu Asn Tyr Tyr Cys Thr 980 985 990 Asn His Lys Pro Gln Leu Ser Phe Pro Leu Cys Ser Ala Gly Asn Ile 995 1000 1005 Phe Gly Leu Tyr Lys Asn Ser Ala Thr Gly Ser Leu Asp Val Glu 1010 1015 1020 Val Phe Asn Arg Leu Ala Thr Ser Asp Trp Thr Asp Val Arg Asp 1025 1030 1035 Tyr Lys Leu Ala Asn Asp Val Lys Asp Thr Leu Arg Leu Phe Ala 1040 1045 1050 Ala Glu Thr Ile Lys Ala Lys Glu Glu Ser Val Lys Ser Ser Tyr 1055 1060 1065 Ala Phe Ala Thr Leu Lys Glu Val Val Gly Pro Lys Glu Leu Leu 1070 1075 1080 Leu Ser Trp Glu Ser Gly Lys Val Lys Pro Pro Leu Asn Arg Asn 1085 1090 1095 Ser Val Phe Thr Cys Phe Gln Ile Ser Lys Asp Ser Lys Phe Gln 1100 1105 1110 Ile Gly Glu Phe Ile Phe Glu Lys Val Glu Tyr Gly Ser Asp Thr 1115 1120 1125 Val Thr Tyr Lys Ser Thr Val Thr Thr Lys Leu Val Pro Gly Met 1130 1135 1140 Ile Phe Val Leu Thr Ser His Asn Val Gln Pro Leu Arg Ala Pro 1145 1150 1155 Thr Ile Ala Asn Gln Glu Lys Tyr Ser Ser Ile Tyr Lys Leu His 1160 1165 1170 Pro Ala Phe Asn Val Ser Asp Ala Tyr Ala Asn Leu Val Pro Tyr 1175 1180 1185 Tyr Gln Leu Ile Gly Lys Gln Lys Ile Thr Thr Ile Gln Gly Pro 1190 1195 1200 Pro Gly Ser Gly Lys Ser His Cys Ser Ile Gly Leu Gly Leu Tyr 1205 1210 1215 Tyr Pro Gly Ala Arg Ile Val Phe Val Ala Cys Ala His Ala Ala 1220 1225 1230 Val Asp Ser Leu Cys Ala Lys Ala Met Thr Val Tyr Ser Ile Asp 1235 1240 1245 Lys Cys Thr Arg Ile Ile Pro Ala Arg Ala Arg Val Glu Cys Tyr 1250 1255 1260 Ser Gly Phe Lys Pro Asn Asn Thr Ser Ala Gln Tyr Ile Phe Ser 1265 1270 1275 Thr Val Asn Ala Leu Pro Glu Cys Asn Ala Asp Ile Val Val Val 1280 1285 1290 Asp Glu Val Ser Met Cys Thr Asn Tyr Asp Leu Ser Val Ile Asn 1295 1300 1305 Gln Arg Leu Ser Tyr Lys His Ile Val Tyr Val Gly Asp Pro Gln 1310 1315 1320 Gln Leu Pro Ala Pro Arg Val Met Ile Thr Lys Gly Val Met Glu 1325 1330 1335 Pro Val Asp Tyr Asn Val Val Thr Gln Arg Met Cys Ala Ile Gly 1340 1345 1350 Pro Asp Val Phe Leu His Lys Cys Tyr Arg Cys Pro Ala Glu Ile 1355 1360 1365 Val Asn Thr Val Ser Glu Leu Val Tyr Glu Asn Lys Phe Val Pro 1370 1375 1380 Val Lys Pro Ala Ser Lys Gln Cys Phe Lys Ile Phe Phe Lys Gly 1385 1390 1395 Asn Val Gln Val Asp Asn Gly Ser Ser Ile Asn Arg Lys Gln Leu 1400 1405 1410 Glu Ile Val Lys Leu Phe Leu Val Lys Asn Pro Ser Trp Ser Lys 1415 1420 1425 Ala Val Phe Ile Ser Pro Tyr Asn Ser Gln Asn Tyr Val Ala Ser 1430 1435 1440 Arg Phe Leu Gly Leu Gln Ile Gln Thr Val Asp Ser Ser Gln Gly 1445 1450 1455 Ser Glu Tyr Asp Tyr Val Ile Tyr Ala Gln Thr Ser Asp Thr Ala 1460 1465 1470 His Ala Cys Asn Val Asn Arg Phe Asn Val Ala Ile Thr Arg Ala 1475 1480 1485 Lys Lys Gly Ile Phe Cys Val Met Cys Asp Lys Thr Leu Phe Asp 1490 1495 1500 Ser Leu Lys Phe Phe Glu Ile Lys His Ala Asp Leu His Ser Ser 1505 1510 1515 Gln Val Cys Gly Leu Phe Lys Asn Cys Thr Arg Thr Pro Leu Asn 1520 1525 1530 Leu Pro Pro Thr His Ala His Thr Phe Leu Ser Leu Ser Asp Gln 1535 1540 1545 Phe Lys Thr Thr Gly Asp Leu Ala Val Gln Ile Gly Ser Asn Asn 1550 1555 1560 Val Cys Thr Tyr Glu His Val Ile Ser Phe Met Gly Phe Arg Phe 1565 1570 1575 Asp Ile Ser Ile Pro Gly Ser His Ser Leu Phe Cys Thr Arg Asp 1580 1585 1590 Phe Ala Ile Arg Asn Val Arg Gly Trp Leu Gly Met Asp Val Glu 1595 1600 1605 Ser Ala His Val Cys Gly Asp Asn Ile Gly Thr Asn Val Pro Leu 1610 1615 1620 Gln Val Gly Phe Ser Asn Gly Val Asn Phe Val Val Gln Thr Glu 1625 1630 1635 Gly Cys Val Ser Thr Asn Phe Gly Asp Val Ile Lys Pro Val Cys 1640 1645 1650 Ala Lys Ser Pro Pro Gly Glu Gln Phe Arg His Leu Val Pro Phe 1655 1660 1665 Leu Arg Lys Gly Gln Pro Trp Leu Ile Val Arg Arg Arg Ile Val 1670 1675 1680 Gln Met Ile Ser Asp Tyr Leu Ser Asn Leu Ser Asp Ile Leu Val 1685 1690 1695 Phe Val Leu Trp Ala Gly Ser Leu Glu Leu Thr Thr Met Arg Tyr 1700 1705 1710 Phe Val Lys Ile Gly Pro Ile Lys Tyr Cys Tyr Cys Gly Asn Ser 1715 1720 1725 Ala Thr Cys Tyr Asn Ser Val Ser Asn Glu Tyr Cys Cys Phe Lys 1730 1735 1740 His Ala Leu Gly Cys Asp Tyr Val Tyr Asn Pro Tyr Ala Phe Asp 1745 1750 1755 Ile Gln Gln Trp Gly Tyr Val Gly Ser Leu Ser Gln Asn His His 1760 1765 1770 Thr Phe Cys Asn Ile His Arg Asn Glu His Asp Ala Ser Gly Asp 1775 1780 1785 Ala Val Met Thr Arg Cys Leu Ala Val His Asp Cys Phe Val Lys 1790 1795 1800 Asn Val Asp Trp Thr Val Thr Tyr Pro Phe Ile Ala Asn Glu Lys 1805 1810 1815 Phe Ile Asn Gly Cys Gly Arg Asn Val Gln Gly His Val Val Arg 1820 1825 1830 Ala Ala Leu Lys Leu Tyr Lys Pro Ser Val Ile His Asp Ile Gly 1835 1840 1845 Asn Pro Lys Gly Val Arg Cys Ala Val Thr Asp Ala Lys Trp Tyr 1850 1855 1860 Cys Tyr Asp Lys Gln Pro Val Asn Ser Asn Val Lys Leu Leu Asp 1865 1870 1875 Tyr Asp Tyr Ala Thr His Gly Gln Leu Asp Gly Leu Cys Leu Phe 1880 1885 1890 Trp Asn Cys Asn Val Asp Met Tyr Pro Glu Phe Ser Ile Val Cys 1895 1900 1905 Arg Phe Asp Thr Arg Thr Arg Ser Val Phe Asn Leu Glu Gly Val 1910 1915 1920 Asn Gly Gly Ser Leu Tyr Val Asn Lys His Ala Phe His Thr Pro 1925 1930 1935 Ala Tyr Asp Lys Arg Ala Phe Val Lys Leu Lys Pro Met Pro Phe 1940 1945 1950 Phe Tyr Phe Asp Asp Ser Asp Cys Asp Val Val Gln Glu Gln Val 1955 1960 1965 Asn Tyr Val Pro Leu Arg Ala Ser Ser Cys Val Thr Arg Cys Asn 1970 1975 1980 Ile Gly Gly Ala Val Cys Ser Lys His Ala Asn Leu Tyr Gln Lys 1985 1990 1995 Tyr Val Glu Ala Tyr Asn Thr Phe Thr Gln Ala Gly Phe Asn Ile 2000 2005 2010 Trp Val Pro His Ser Phe Asp Val Tyr Asn Leu Trp Gln Ile Phe 2015 2020 2025 Ile Glu Thr Asn Leu Gln Ser Leu Glu Asn Ile Ala Phe Asn Val 2030 2035 2040 Val Lys Lys Gly Cys Phe Thr Gly Val Asp Gly Glu Leu Pro Val 2045 2050 2055 Ala Val Val Asn Asp Lys Val Phe Val Arg Tyr Gly Asp Val Asp 2060 2065 2070 Asn Leu Val Phe Thr Asn Lys Thr Thr Leu Pro Thr Asn Val Ala 2075 2080 2085 Phe Glu Leu Phe Ala Lys Arg Lys Met Gly Leu Thr Pro Pro Leu 2090 2095 2100 Ser Ile Leu Lys Asn Leu Gly Val Val Ala Thr Tyr Lys Phe Val 2105 2110 2115 Leu Trp Asp Tyr Glu Ala Glu Arg Pro Phe Thr Ser Tyr Thr Lys 2120 2125 2130 Ser Val Cys Lys Tyr Thr Asp Phe Asn Glu Asp Val Cys Val Cys 2135 2140 2145 Phe Asp Asn Ser Ile Gln Gly Ser Tyr Glu Arg Phe Thr Leu Thr 2150 2155 2160 Thr Asn Ala Val Leu Phe Ser Thr Val Val Ile Lys Asn Leu Thr 2165 2170 2175 Pro Ile Lys Leu Asn Phe Gly Met Leu Asn Gly Met Pro Val Ser 2180 2185 2190 Ser Ile Lys Ser Asp Lys Gly Val Glu Lys Leu Val Asn Trp Tyr 2195 2200 2205 Thr Tyr Val Arg Lys Asn Gly Gln Phe Gln Asp His Tyr Asp Gly 2210 2215 2220 Phe Tyr Thr Gln Gly Arg Asn Leu Ser Asp Phe Thr Pro Arg Ser 2225 2230 2235 Asp Met Glu Tyr Asp Phe Leu Asn Met Asp Met Gly Val Phe Ile 2240 2245 2250 Asn Lys Tyr Gly Leu Glu Asp Phe Asn Phe Glu His Val Val Tyr 2255 2260 2265 Gly Asp Val Ser Lys Thr Thr Leu Gly Gly Leu His Leu Leu Ile 2270 2275 2280 Ser Gln Phe Arg Leu Ser Lys Met Gly Val Leu Lys Ala Asp Asp 2285 2290 2295 Phe Val Thr Ala Ser Asp Thr Thr Leu Arg Cys Cys Thr Val Thr 2300 2305 2310 Tyr Leu Asn Glu Leu Ser Ser Lys Val Val Cys Thr Tyr Met Asp 2315 2320 2325 Leu Leu Leu Asp Asp Phe Val Thr Ile Leu Lys Ser Leu Asp Leu 2330 2335 2340 Gly Val Ile Ser Lys Val His Glu Val Ile Ile Asp Asn Lys Pro 2345 2350 2355 Tyr Arg Trp Met Leu Trp Cys Lys Asp Asn His Leu Ser Thr Phe 2360 2365 2370 Tyr Pro Gln Leu Gln Ser Ala Glu Trp Lys Cys Gly Tyr Ala Met 2375 2380 2385 Pro Gln Ile Tyr Lys Leu Gln Arg Met Cys Leu Glu Pro Cys Asn 2390 2395 2400 Leu Tyr Asn Tyr Gly Ala Gly Ile Lys Leu Pro Ser Gly Ile Met 2405 2410 2415 Leu Asn Val Val Lys Tyr Thr Gln Leu Cys Gln Tyr Leu Asn Ser 2420 2425 2430 Thr Thr Met Cys Val Pro His Asn Met Arg Val Leu His Tyr Gly 2435 2440 2445 Ala Gly Ser Asp Lys Gly Val Ala Pro Gly Thr Thr Val Leu Lys 2450 2455 2460 Arg Trp Leu Pro Pro Asp Ala Ile Ile Ile Asp Asn Asp Ile Asn 2465 2470 2475 Asp Tyr Val Ser Asp Ala Asp Phe Ser Ile Thr Gly Asp Cys Ala 2480 2485 2490 Thr Val Tyr Leu Glu Asp Lys Phe Asp Leu Leu Ile Ser Asp Met 2495 2500 2505 Tyr Asp Gly Arg Ile Lys Phe Cys Asp Gly Glu Asn Val Ser Lys 2510 2515 2520 Asp Gly Phe Phe Thr Tyr Leu Asn Gly Val Ile Arg Glu Lys Leu 2525 2530 2535 Ala Ile Gly Gly Ser Val Ala Ile Lys Ile Thr Glu Tyr Ser Trp 2540 2545 2550 Asn Lys Tyr Leu Tyr Glu Leu Ile Gln Arg Phe Ala Phe Trp Thr 2555 2560 2565 Leu Phe Cys Thr Ser Val Asn Thr Ser Ser Ser Glu Ala Phe Leu 2570 2575 2580 Ile Gly Ile Asn Tyr Leu Gly Asp Phe Ile Gln Gly Pro Phe Ile 2585 2590 2595 Ala Gly Asn Thr Val His Ala Asn Tyr Ile Phe Trp Arg Asn Ser 2600 2605 2610 Thr Ile Met Ser Leu Ser Tyr Asn Ser Val Leu Asp Leu Ser Lys 2615 2620 2625 Phe Glu Cys Lys His Lys Ala Thr Val Val Val Thr Leu Lys Asp 2630 2635 2640 Ser Asp Val Asn Asp Met Val Leu Ser Leu Ile Lys Ser Gly Arg 2645 2650 2655 Leu Leu Leu Arg Asn Ser Gly Arg Phe Gly Gly Phe Ser Asn His 2660 2665 2670 Leu Val Ser Thr Lys 2675 <210> 9 <211> 226 <212> PRT <213> EMCR Coronavirus <400> 9 Met Pro Phe Gly Gly Leu Phe Gln Leu Thr Leu Glu Ser Thr Ile Asn 1 5 10 15 Lys Ser Val Ala Asn Leu Lys Leu Pro Pro His Asp Val Thr Val Leu 20 25 30 Arg Asp Asn Leu Lys Pro Val Thr Thr Leu Ser Thr Ile Thr Ala Tyr 35 40 45 Leu Leu Val Ser Leu Phe Val Thr Tyr Phe Ala Leu Phe Lys Pro Leu 50 55 60 Thr Ala Arg Gly Arg Val Ala Cys Phe Val Leu Lys Leu Leu Thr Leu 65 70 75 80 Ser Val Tyr Val Pro Leu Leu Val Leu Phe Gly Met Tyr Leu Asp Ser 85 90 95 Phe Ile Ile Phe Phe Leu Arg Cys Cys Phe Asp Ser Tyr Met Leu Ala 100 105 110 Ile Met Pro Ile Ser Asn Lys Asn Phe Ser Phe Val Leu Phe Asn Val 115 120 125 Thr Lys Leu Cys Phe Val Ser Gly Lys Cys Trp Tyr Leu Glu Gln Ser 130 135 140 Phe Tyr Glu Asn Arg Phe Ala Ala Ile Tyr Gly Gly Asp His Tyr Val 145 150 155 160 Val Leu Gly Gly Glu Thr Ile Thr Phe Val Ser Phe Asp Asp Leu Tyr 165 170 175 Val Ala Ile Arg Gly Ser Cys Glu Lys Asn Leu Gln Leu Met Arg Lys 180 185 190 Val Asp Leu Tyr Asn Gly Ala Val Ile Tyr Ile Phe Ala Glu Glu Pro 195 200 205 Val Val Gly Ile Val Tyr Ser Ser Gln Leu Tyr Glu Asp Val Pro Ser 210 215 220 Ile Asn 225 <210> 10 <211> 292 <212> DNA <213> Coronavirus 229E <220> <221> 5'UTR <222> (1)..(292) <400> 10 acttaagtac cttatctatc tacagataga aaagttgctt tttagacttt gtgtctactt 60 ttctcaacta aacgaaattt ttgctatggc cggcatcttt gatgctggag tcgtagtgta 120 attgaaattt catttgggtt gcaacagttt ggaagcaagt gctgtgtgtc ctagtctaag 180 ggtttcgtgt tccgtcacga gattccattc tacaaacgcc ttactcgagg ttccgtctcg 240 tgtttgtgtg gaagcaaagt tctgtctttg tggaaaccag taactgttcc ta 292 <210> 11 <211> 3951 <212> PRT <213> avian infectious bronchitis virus <220> <221> MISC_FEATURE <223> ORF1A <400> 11 Met Ala Ser Ser Leu Lys Gln Gly Val Ser Pro Lys Pro Arg Asp Val 1 5 10 15 Ile Leu Val Ser Lys Asp Ile Pro Glu Gln Leu Cys Asp Ala Leu Phe 20 25 30 Phe Tyr Thr Ser His Asn Pro Lys Asp Tyr Ala Asp Ala Phe Ala Val 35 40 45 Arg Gln Lys Phe Asp Arg Ser Leu Gln Thr Gly Lys Gln Phe Lys Phe 50 55 60 Glu Thr Val Cys Gly Leu Phe Leu Leu Lys Gly Val Asp Lys Ile Thr 65 70 75 80 Pro Gly Val Pro Ala Lys Val Leu Lys Ala Thr Ser Lys Leu Ala Asp 85 90 95 Leu Glu Asp Ile Phe Gly Val Ser Pro Leu Ala Arg Lys Tyr Arg Glu 100 105 110 Leu Leu Lys Thr Ala Cys Gln Trp Ser Leu Thr Val Glu Ala Leu Asp 115 120 125 Val Arg Ala Gln Thr Leu Asp Glu Ile Phe Asp Pro Thr Glu Ile Leu 130 135 140 Trp Leu Gln Val Ala Ala Lys Ile His Val Ser Ser Met Ala Met Arg 145 150 155 160 Arg Leu Val Gly Glu Val Thr Ala Lys Val Met Asp Ala Leu Gly Ser 165 170 175 Asn Leu Ser Ala Leu Phe Gln Ile Val Lys Gln Gln Ile Ala Arg Ile 180 185 190 Phe Gln Lys Ala Leu Ala Ile Phe Glu Asn Val Asn Glu Leu Pro Gln 195 200 205 Arg Ile Ala Ala Leu Lys Met Ala Phe Ala Lys Cys Ala Arg Ser Ile 210 215 220 Thr Val Val Val Val Glu Arg Thr Leu Val Val Lys Glu Phe Ala Gly 225 230 235 240 Thr Cys Leu Ala Ser Ile Asn Gly Ala Val Ala Lys Phe Phe Glu Glu 245 250 255 Leu Pro Asn Gly Phe Met Gly Ser Lys Ile Phe Thr Thr Leu Ala Phe 260 265 270 Phe Lys Glu Ala Ala Val Arg Val Val Glu Asn Ile Pro Asn Ala Pro 275 280 285 Arg Gly Thr Lys Gly Phe Glu Val Val Gly Asn Ala Lys Gly Thr Gln 290 295 300 Val Val Val Arg Gly Met Arg Asn Asp Leu Thr Leu Leu Asp Gln Lys 305 310 315 320 Ala Asp Ile Pro Val Glu Pro Glu Gly Trp Ser Ala Ile Leu Asp Gly 325 330 335 His Leu Cys Tyr Val Phe Arg Ser Gly Asp Arg Phe Tyr Ala Ala Pro 340 345 350 Leu Ser Gly Asn Phe Ala Leu Ser Asp Val His Cys Cys Glu Arg Val 355 360 365 Val Cys Leu Ser Asp Gly Val Thr Pro Glu Ile Asn Asp Gly Leu Ile 370 375 380 Leu Ala Ala Ile Tyr Ser Ser Phe Ser Val Ser Glu Leu Val Thr Ala 385 390 395 400 Leu Lys Lys Gly Glu Pro Phe Lys Phe Leu Gly His Lys Phe Val Tyr 405 410 415 Ala Lys Asp Ala Ala Val Ser Phe Thr Leu Ala Lys Ala Ala Thr Ile 420 425 430 Ala Asp Val Leu Arg Leu Phe Gln Ser Ala Arg Val Ile Ala Glu Asp 435 440 445 Val Trp Ser Ser Phe Thr Glu Lys Ser Phe Glu Phe Trp Lys Leu Ala 450 455 460 Tyr Gly Lys Val Arg Asn Leu Glu Glu Phe Val Lys Thr Tyr Val Cys 465 470 475 480 Lys Ala Gln Met Ser Ile Val Ile Leu Ala Ala Val Leu Gly Glu Asp 485 490 495 Ile Trp His Leu Val Ser Gln Val Ile Tyr Lys Leu Gly Val Leu Phe 500 505 510 Thr Lys Val Val Asp Phe Cys Asp Lys His Trp Lys Gly Phe Cys Val 515 520 525 Gln Leu Lys Arg Ala Lys Leu Ile Val Thr Glu Thr Phe Cys Val Leu 530 535 540 Lys Gly Val Ala Gln His Cys Phe Gln Leu Leu Leu Asp Ala Ile His 545 550 555 560 Ser Leu Tyr Lys Ser Phe Lys Lys Cys Ala Leu Gly Arg Ile His Gly 565 570 575 Asp Leu Leu Phe Trp Lys Gly Gly Val His Lys Ile Val Gln Asp Gly 580 585 590 Asp Glu Ile Trp Phe Asp Ala Ile Asp Ser Val Asp Val Glu Asp Leu 595 600 605 Gly Val Val Gln Glu Lys Ser Ile Asp Phe Glu Val Cys Asp Asp Val 610 615 620 Thr Leu Pro Glu Asn Gln Pro Gly His Met Val Gln Ile Glu Asp Asp 625 630 635 640 Gly Lys Asn Tyr Met Phe Phe Arg Phe Lys Lys Asp Glu Asn Ile Tyr 645 650 655 Tyr Thr Pro Met Ser Gln Leu Gly Ala Ile Asn Val Val Cys Lys Ala 660 665 670 Gly Gly Lys Thr Val Thr Phe Gly Glu Thr Thr Val Gln Glu Ile Pro 675 680 685 Pro Pro Asp Val Val Pro Ile Lys Val Ser Ile Glu Cys Cys Gly Glu 690 695 700 Pro Trp Asn Thr Ile Phe Lys Lys Ala Tyr Lys Glu Pro Ile Glu Val 705 710 715 720 Asp Thr Asp Leu Thr Val Glu Gln Leu Leu Ser Val Ile Tyr Glu Lys 725 730 735 Met Cys Asp Asp Leu Lys Leu Phe Pro Glu Ala Pro Glu Pro Pro Pro 740 745 750 Phe Glu Asn Val Ala Leu Val Asp Lys Asn Gly Lys Asp Leu Asp Cys 755 760 765 Ile Lys Ser Cys His Leu Ile Tyr Arg Asp Tyr Glu Ser Asp Asp Asp 770 775 780 Ile Glu Glu Glu Asp Ala Glu Glu Cys Asp Thr Asp Ser Gly Glu Ala 785 790 795 800 Glu Glu Cys Asp Thr Asn Ser Glu Cys Glu Glu Glu Asp Glu Asp Thr 805 810 815 Lys Val Leu Ala Leu Ile Gln Asp Pro Ala Ser Ile Lys Tyr Pro Leu 820 825 830 Pro Leu Asp Glu Asp Tyr Ser Val Tyr Asn Gly Cys Ile Val His Lys 835 840 845 Asp Ala Leu Asp Val Val Asn Leu Pro Ser Gly Glu Glu Thr Phe Val 850 855 860 Val Asn Asn Cys Phe Glu Gly Ala Val Lys Pro Leu Pro Gln Lys Val 865 870 875 880 Val Asp Val Leu Gly Asp Trp Gly Glu Ala Val Asp Ala Gln Glu Gln 885 890 895 Leu Cys Gln Gln Glu Pro Leu Gln His Thr Phe Glu Glu Pro Val Glu 900 905 910 Asn Ser Thr Gly Ser Ser Lys Thr Met Thr Glu Gln Val Val Val Glu 915 920 925 Asp Gln Glu Leu Pro Val Val Glu Gln Asp Gln Asp Val Val Val Tyr 930 935 940 Thr Pro Thr Asp Leu Glu Val Ala Lys Glu Thr Ala Glu Glu Val Asp 945 950 955 960 Glu Phe Ile Leu Ile Phe Ala Val Pro Lys Glu Glu Val Val Ser Gln 965 970 975 Lys Asp Gly Ala Gln Ile Lys Gln Glu Pro Ile Gln Val Val Lys Pro 980 985 990 Gln Arg Glu Lys Lys Ala Lys Lys Phe Lys Val Lys Pro Ala Thr Cys 995 1000 1005 Glu Lys Pro Lys Phe Leu Glu Tyr Lys Thr Cys Val Gly Asp Leu 1010 1015 1020 Thr Val Val Ile Ala Lys Ala Leu Asp Glu Phe Lys Glu Phe Cys 1025 1030 1035 Ile Val Asn Ala Ala Asn Glu His Met Thr His Gly Ser Gly Val 1040 1045 1050 Ala Lys Ala Ile Ala Asp Phe Cys Gly Leu Asp Phe Val Glu Tyr 1055 1060 1065 Cys Glu Asp Tyr Val Lys Lys His Gly Pro Gln Gln Arg Leu Val 1070 1075 1080 Thr Pro Ser Phe Val Lys Gly Ile Gln Cys Val Asn Asn Val Val 1085 1090 1095 Gly Pro Arg His Gly Asp Asn Asn Leu His Glu Lys Leu Val Ala 1100 1105 1110 Ala Tyr Lys Asn Val Leu Val Asp Gly Val Val Asn Tyr Val Val 1115 1120 1125 Pro Val Leu Ser Leu Gly Ile Phe Gly Val Asp Phe Lys Met Ser 1130 1135 1140 Ile Asp Ala Met Arg Glu Ala Phe Glu Gly Cys Thr Ile Arg Val 1145 1150 1155 Leu Leu Phe Ser Leu Ser Gln Glu His Ile Asp Tyr Phe Asp Val 1160 1165 1170 Thr Cys Lys Gln Lys Thr Ile Tyr Leu Thr Glu Asp Gly Val Lys 1175 1180 1185 Tyr Arg Ser Ile Val Leu Lys Pro Gly Asp Ser Leu Gly Gln Phe 1190 1195 1200 Gly Gln Val Tyr Ala Lys Asn Lys Ile Val Phe Thr Ala Asp Asp 1205 1210 1215 Val Glu Asp Lys Glu Ile Leu Tyr Val Pro Thr Thr Asp Lys Ser 1220 1225 1230 Ile Leu Glu Tyr Tyr Gly Leu Asp Ala Gln Lys Tyr Val Ile Tyr 1235 1240 1245 Leu Gln Thr Leu Ala Gln Lys Trp Asn Val Gln Tyr Arg Asp Asn 1250 1255 1260 Phe Leu Ile Leu Glu Trp Arg Asp Gly Asn Cys Trp Ile Ser Ser 1265 1270 1275 Ala Ile Val Leu Leu Gln Ala Ala Lys Ile Arg Phe Lys Gly Phe 1280 1285 1290 Leu Thr Glu Ala Trp Ala Lys Leu Leu Gly Gly Asp Pro Thr Asp 1295 1300 1305 Phe Val Ala Trp Cys Tyr Ala Ser Cys Thr Ala Lys Val Gly Asp 1310 1315 1320 Phe Ser Asp Ala Asn Trp Leu Leu Ala Asn Leu Ala Glu His Phe 1325 1330 1335 Asp Ala Asp Tyr Thr Asn Ala Phe Leu Lys Lys Arg Val Ser Cys 1340 1345 1350 Asn Cys Gly Ile Lys Ser Tyr Glu Leu Arg Gly Leu Glu Ala Cys 1355 1360 1365 Ile Gln Pro Val Arg Ala Thr Asn Leu Leu His Phe Lys Thr Gln 1370 1375 1380 Tyr Ser Asn Cys Pro Thr Cys Gly Ala Asn Asn Thr Asp Glu Val 1385 1390 1395 Ile Glu Ala Ser Leu Pro Tyr Leu Leu Leu Phe Ala Thr Asp Gly 1400 1405 1410 Pro Ala Thr Val Asp Cys Asp Glu Asp Ala Val Gly Thr Val Val 1415 1420 1425 Phe Val Gly Ser Thr Asn Ser Gly His Cys Tyr Thr Gln Ala Ala 1430 1435 1440 Gly Gln Ala Phe Asp Asn Leu Ala Lys Asp Arg Lys Phe Gly Lys 1445 1450 1455 Lys Ser Pro Tyr Ile Thr Ala Met Tyr Thr Arg Phe Ala Phe Lys 1460 1465 1470 Asn Glu Thr Ser Leu Pro Val Ala Lys Gln Ser Lys Gly Lys Ser 1475 1480 1485 Lys Ser Val Lys Glu Asp Val Ser Asn Leu Ala Thr Ser Ser Lys 1490 1495 1500 Ala Ser Phe Asp Asn Leu Thr Asp Phe Glu Gln Trp Tyr Asp Ser 1505 1510 1515 Asn Ile Tyr Glu Ser Leu Lys Val Gln Glu Ser Pro Asp Asn Phe 1520 1525 1530 Asp Lys Tyr Val Ser Phe Thr Thr Lys Glu Asp Ser Lys Leu Pro 1535 1540 1545 Leu Thr Leu Lys Val Arg Gly Ile Lys Ser Val Val Asp Phe Arg 1550 1555 1560 Ser Lys Asp Gly Phe Ile Tyr Lys Leu Thr Pro Asp Thr Asp Glu 1565 1570 1575 Asn Ser Lys Ala Pro Val Tyr Tyr Pro Val Leu Asp Ala Ile Ser 1580 1585 1590 Leu Lys Ala Ile Trp Val Glu Gly Asn Ala Asn Phe Val Val Gly 1595 1600 1605 His Pro Asn Tyr Tyr Ser Lys Ser Leu His Ile Pro Thr Phe Trp 1610 1615 1620 Glu Asn Ala Glu Asn Phe Val Lys Met Gly Asp Lys Ile Gly Gly 1625 1630 1635 Val Thr Met Gly Leu Trp Arg Ala Glu His Leu Asn Lys Pro Asn 1640 1645 1650 Leu Glu Arg Ile Phe Asn Ile Ala Lys Lys Ala Ile Val Gly Ser 1655 1660 1665 Ser Val Val Thr Thr Gln Cys Gly Lys Leu Ile Gly Lys Ala Ala 1670 1675 1680 Thr Phe Ile Ala Asp Lys Val Gly Gly Gly Val Val Arg Asn Ile 1685 1690 1695 Thr Asp Ser Ile Lys Gly Leu Cys Gly Ile Thr Arg Gly His Phe 1700 1705 1710 Glu Arg Lys Met Ser Pro Gln Phe Leu Lys Thr Leu Met Phe Phe 1715 1720 1725 Leu Phe Tyr Phe Leu Lys Ala Ser Val Lys Ser Val Val Ala Ser 1730 1735 1740 Tyr Lys Thr Val Leu Cys Lys Val Val Leu Ala Thr Leu Leu Ile 1745 1750 1755 Val Trp Phe Val Tyr Thr Ser Asn Pro Val Met Phe Thr Gly Ile 1760 1765 1770 Arg Val Leu Asp Phe Leu Phe Glu Gly Ser Leu Cys Gly Pro Tyr 1775 1780 1785 Lys Asp Tyr Gly Lys Asp Ser Phe Asp Val Leu Arg Tyr Cys Ala 1790 1795 1800 Asp Asp Phe Ile Cys Arg Val Cys Leu His Asp Lys Asp Ser Leu 1805 1810 1815 His Leu Tyr Lys His Ala Tyr Ser Val Glu Gln Val Tyr Lys Asp 1820 1825 1830 Ala Ala Ser Gly Phe Ile Phe Asn Trp Asn Trp Leu Tyr Leu Val 1835 1840 1845 Phe Leu Ile Leu Phe Val Lys Pro Val Ala Gly Phe Val Ile Ile 1850 1855 1860 Cys Tyr Cys Val Lys Tyr Leu Val Leu Asn Ser Thr Val Leu Gln 1865 1870 1875 Thr Gly Val Cys Phe Leu Asp Trp Phe Val Gln Thr Val Phe Ser 1880 1885 1890 His Phe Asn Phe Met Gly Ala Gly Phe Tyr Phe Trp Leu Phe Tyr 1895 1900 1905 Lys Ile Tyr Ile Gln Val His His Ile Leu Tyr Cys Lys Asp Val 1910 1915 1920 Thr Cys Glu Val Cys Lys Arg Val Ala Arg Ser Asn Arg Gln Glu 1925 1930 1935 Val Ser Val Val Val Gly Gly Arg Lys Gln Ile Val His Val Tyr 1940 1945 1950 Thr Asn Ser Gly Tyr Asn Phe Cys Lys Arg His Asn Trp Tyr Cys 1955 1960 1965 Arg Asn Cys Asp Asp Tyr Gly His Gln Asn Thr Phe Met Ser Pro 1970 1975 1980 Glu Val Ala Gly Glu Leu Ser Glu Lys Leu Lys Arg His Val Lys 1985 1990 1995 Pro Thr Ala Tyr Ala Tyr His Val Val Asp Glu Ala Cys Leu Val 2000 2005 2010 Asp Asp Phe Val Asn Leu Lys Tyr Lys Ala Ala Thr Pro Gly Lys 2015 2020 2025 Asp Ser Ala Ser Ser Ala Val Lys Cys Phe Ser Val Thr Asp Phe 2030 2035 2040 Leu Lys Lys Ala Val Phe Leu Lys Glu Ala Leu Lys Cys Glu Gln 2045 2050 2055 Ile Ser Asn Asp Gly Phe Ile Val Cys Asn Thr Gln Ser Ala His 2060 2065 2070 Ala Leu Glu Glu Ala Lys Asn Ala Ala Ile Tyr Tyr Ala Gln Tyr 2075 2080 2085 Leu Cys Lys Pro Ile Leu Ile Leu Asp Gln Ala Leu Tyr Glu Gln 2090 2095 2100 Leu Val Val Glu Pro Val Ser Lys Ser Val Ile Asp Lys Val Cys 2105 2110 2115 Ser Ile Leu Ser Ser Ile Ile Ser Val Asp Thr Ala Ala Leu Asn 2120 2125 2130 Tyr Lys Ala Gly Thr Leu Arg Asp Ala Leu Leu Ser Ile Thr Lys 2135 2140 2145 Asp Glu Glu Ala Val Asp Met Ala Ile Phe Cys His Asn His Asp 2150 2155 2160 Val Asp Tyr Thr Gly Asp Gly Phe Thr Asn Val Ile Pro Ser Tyr 2165 2170 2175 Gly Ile Asp Thr Gly Lys Leu Thr Pro Arg Asp Arg Gly Phe Leu 2180 2185 2190 Ile Asn Ala Asp Ala Ser Ile Ala Asn Leu Arg Val Lys Asn Ala 2195 2200 2205 Pro Pro Val Val Trp Lys Phe Ser Glu Leu Ile Lys Leu Ser Asp 2210 2215 2220 Ser Cys Leu Lys Tyr Leu Ile Ser Ala Thr Val Lys Ser Gly Val 2225 2230 2235 Arg Phe Phe Ile Thr Lys Ser Gly Ala Lys Gln Val Ile Ala Cys 2240 2245 2250 His Thr Gln Lys Leu Leu Val Glu Lys Lys Ala Gly Gly Ile Val 2255 2260 2265 Ser Gly Thr Phe Lys Cys Phe Lys Ser Tyr Phe Lys Trp Leu Leu 2270 2275 2280 Ile Phe Tyr Ile Leu Phe Thr Ala Cys Cys Ser Gly Tyr Tyr Tyr 2285 2290 2295 Met Glu Val Ser Lys Ser Phe Val His Pro Met Tyr Asp Val Asn 2300 2305 2310 Ser Thr Leu His Val Glu Gly Phe Lys Val Ile Asp Lys Gly Val 2315 2320 2325 Leu Arg Glu Ile Val Pro Glu Asp Thr Cys Phe Ser Asn Lys Phe 2330 2335 2340 Val Asn Phe Asp Ala Phe Trp Gly Arg Pro Tyr Asp Asn Ser Arg 2345 2350 2355 Asn Cys Pro Ile Val Thr Ala Val Ile Asp Gly Asp Gly Thr Val 2360 2365 2370 Ala Thr Gly Val Pro Gly Phe Val Ser Trp Val Met Asp Gly Val 2375 2380 2385 Met Phe Ile His Met Thr Gln Thr Glu Arg Lys Pro Trp Tyr Ile 2390 2395 2400 Pro Thr Trp Phe Asn Arg Glu Ile Val Gly Tyr Thr Gln Asp Ser 2405 2410 2415 Ile Ile Thr Glu Gly Ser Phe Tyr Thr Ser Ile Ala Leu Phe Ser 2420 2425 2430 Ala Arg Cys Leu Tyr Leu Thr Ala Ser Asn Thr Pro Gln Leu Tyr 2435 2440 2445 Cys Phe Asn Gly Asp Asn Asp Ala Pro Gly Ala Leu Pro Phe Gly 2450 2455 2460 Ser Ile Ile Pro His Arg Val Tyr Phe Gln Pro Asn Gly Val Arg 2465 2470 2475 Leu Ile Val Pro Gln Gln Ile Leu His Thr Pro Tyr Val Val Lys 2480 2485 2490 Phe Val Ser Asp Ser Tyr Cys Arg Gly Ser Val Cys Glu Tyr Thr 2495 2500 2505 Arg Pro Gly Tyr Cys Val Ser Leu Asn Pro Gln Trp Val Leu Phe 2510 2515 2520 Asn Asp Glu Tyr Thr Ser Lys Pro Gly Val Phe Cys Gly Ser Thr 2525 2530 2535 Val Arg Glu Leu Met Phe Ser Met Val Ser Thr Phe Phe Thr Gly 2540 2545 2550 Val Asn Pro Asn Ile Tyr Met Gln Leu Ala Thr Met Phe Leu Ile 2555 2560 2565 Leu Val Val Val Val Leu Ile Phe Ala Met Val Ile Lys Phe Gln 2570 2575 2580 Gly Val Phe Lys Ala Tyr Ala Thr Thr Val Phe Ile Thr Met Leu 2585 2590 2595 Val Trp Val Ile Asn Ala Phe Ile Leu Cys Val His Ser Tyr Asn 2600 2605 2610 Ser Val Leu Ala Val Ile Leu Leu Val Leu Tyr Cys Tyr Ala Ser 2615 2620 2625 Leu Val Thr Ser Arg Asn Thr Val Ile Ile Met His Cys Trp Leu 2630 2635 2640 Val Phe Thr Phe Gly Leu Ile Val Pro Thr Trp Leu Ala Cys Cys 2645 2650 2655 Tyr Leu Gly Phe Ile Ile Tyr Met Tyr Thr Pro Leu Phe Leu Trp 2660 2665 2670 Cys Tyr Gly Thr Thr Lys Asn Thr Arg Lys Leu Tyr Asp Gly Asn 2675 2680 2685 Glu Phe Val Gly Asn Tyr Asp Leu Ala Ala Lys Ser Thr Phe Val 2690 2695 2700 Ile Arg Gly Ser Glu Phe Val Lys Leu Thr Asn Glu Ile Gly Asp 2705 2710 2715 Lys Phe Glu Ala Tyr Leu Ser Ala Tyr Ala Arg Leu Lys Tyr Tyr 2720 2725 2730 Ser Gly Thr Gly Ser Glu Gln Asp Tyr Leu Gln Ala Cys Arg Ala 2735 2740 2745 Trp Leu Ala Tyr Ala Leu Asp Gln Tyr Arg Asn Ser Gly Val Glu 2750 2755 2760 Ile Val Tyr Thr Pro Pro Arg Tyr Ser Ile Gly Val Ser Arg Leu 2765 2770 2775 Gln Ser Gly Phe Lys Lys Leu Val Ser Pro Ser Ser Ala Val Glu 2780 2785 2790 Lys Cys Ile Val Ser Val Ser Tyr Arg Gly Asn Asn Leu Asn Gly 2795 2800 2805 Leu Trp Leu Gly Asp Thr Ile Tyr Cys Pro Arg His Val Leu Gly 2810 2815 2820 Lys Phe Ser Gly Asp Gln Trp Asn Asp Val Leu Asn Leu Ala Asn 2825 2830 2835 Asn His Glu Phe Glu Val Thr Thr Gln His Gly Val Thr Leu Asn 2840 2845 2850 Val Val Ser Arg Arg Leu Lys Gly Ala Val Leu Ile Leu Gln Thr 2855 2860 2865 Ala Val Ala Asn Ala Glu Thr Pro Lys Tyr Lys Phe Ile Lys Ala 2870 2875 2880 Asn Cys Gly Asp Ser Phe Thr Ile Ala Cys Ala Tyr Gly Gly Thr 2885 2890 2895 Val Val Gly Leu Tyr Pro Val Thr Met Arg Ser Asn Gly Thr Ile 2900 2905 2910 Arg Ala Ser Phe Leu Ala Gly Ala Cys Gly Ser Val Gly Phe Asn 2915 2920 2925 Ile Glu Lys Gly Val Val Asn Phe Phe Tyr Met His His Leu Glu 2930 2935 2940 Leu Pro Asn Ala Leu His Thr Gly Thr Asp Leu Met Gly Glu Phe 2945 2950 2955 Tyr Gly Gly Tyr Val Asp Glu Glu Val Ala Gln Arg Val Pro Pro 2960 2965 2970 Asp Asn Leu Val Thr Asn Asn Ile Val Ala Trp Leu Tyr Ala Ala 2975 2980 2985 Ile Ile Ser Val Lys Glu Ser Ser Phe Ser Leu Pro Lys Trp Leu 2990 2995 3000 Glu Ser Thr Thr Val Ser Val Asp Asp Tyr Asn Lys Trp Ala Gly 3005 3010 3015 Asp Asn Gly Phe Thr Pro Phe Ser Thr Ser Thr Ala Ile Thr Lys 3020 3025 3030 Leu Ser Ala Ile Thr Gly Val Asp Val Cys Lys Leu Leu Arg Thr 3035 3040 3045 Ile Met Val Lys Asn Ser Gln Trp Gly Gly Asp Pro Ile Leu Gly 3050 3055 3060 Gln Tyr Asn Phe Glu Asp Glu Leu Thr Pro Glu Ser Val Phe Asn 3065 3070 3075 Gln Ile Gly Gly Val Arg Leu Gln Ser Ser Phe Val Arg Lys Ala 3080 3085 3090 Thr Ser Trp Phe Trp Ser Arg Cys Val Leu Ala Cys Phe Leu Phe 3095 3100 3105 Val Leu Cys Ala Ile Val Leu Phe Thr Ala Val Pro Leu Lys Phe 3110 3115 3120 Tyr Val Tyr Ala Ala Val Ile Leu Leu Met Ala Val Leu Phe Ile 3125 3130 3135 Ser Phe Thr Val Lys His Val Met Ala Tyr Met Asp Thr Phe Leu 3140 3145 3150 Leu Pro Thr Leu Ile Thr Val Ile Ile Gly Val Cys Ala Glu Val 3155 3160 3165 Pro Phe Ile Tyr Asn Thr Leu Ile Ser Gln Val Val Ile Phe Leu 3170 3175 3180 Ser Gln Trp Tyr Asp Pro Val Val Phe Asp Thr Met Val Pro Trp 3185 3190 3195 Met Phe Leu Pro Leu Val Leu Tyr Thr Ala Phe Lys Cys Val Gln 3200 3205 3210 Gly Cys Tyr Met Asn Ser Phe Asn Thr Ser Leu Leu Met Leu Tyr 3215 3220 3225 Gln Phe Val Lys Leu Gly Phe Val Ile Tyr Thr Ser Ser Asn Thr 3230 3235 3240 Leu Thr Ala Tyr Thr Glu Gly Asn Trp Glu Leu Phe Phe Glu Leu 3245 3250 3255 Val His Thr Thr Val Leu Ala Asn Val Ser Ser Asn Ser Leu Ile 3260 3265 3270 Gly Leu Phe Val Phe Lys Cys Ala Lys Trp Met Leu Tyr Tyr Cys 3275 3280 3285 Asn Ala Thr Tyr Leu Asn Asn Tyr Val Leu Met Ala Val Met Val 3290 3295 3300 Asn Cys Ile Gly Trp Leu Cys Thr Cys Tyr Phe Gly Leu Tyr Trp 3305 3310 3315 Trp Val Asn Lys Val Phe Gly Leu Thr Leu Gly Lys Tyr Asn Phe 3320 3325 3330 Lys Val Ser Val Asp Gln Tyr Arg Tyr Met Cys Leu His Lys Ile 3335 3340 3345 Asn Pro Pro Lys Thr Val Trp Glu Val Phe Ser Thr Asn Ile Leu 3350 3355 3360 Ile Gln Gly Ile Gly Gly Asp Arg Val Leu Pro Ile Ala Thr Val 3365 3370 3375 Gln Ala Lys Leu Ser Asp Val Lys Cys Thr Thr Val Val Leu Met 3380 3385 3390 Gln Leu Leu Thr Lys Leu Asn Val Glu Ala Asn Ser Lys Met His 3395 3400 3405 Val Tyr Leu Val Glu Leu His Asn Lys Ile Leu Ala Ser Asp Asp 3410 3415 3420 Val Gly Glu Cys Met Asp Asn Leu Leu Gly Met Leu Ile Thr Leu 3425 3430 3435 Phe Cys Ile Asp Ser Thr Ile Asp Leu Ser Glu Tyr Cys Asp Asp 3440 3445 3450 Ile Leu Lys Arg Ser Thr Val Leu Gln Ser Val Thr Gln Glu Phe 3455 3460 3465 Ser His Ile Pro Ser Tyr Ala Glu Tyr Glu Arg Ala Lys Asn Leu 3470 3475 3480 Tyr Glu Lys Val Leu Val Asp Ser Lys Asn Gly Gly Val Thr Gln 3485 3490 3495 Gln Glu Leu Ala Ala Tyr Arg Lys Ala Ala Asn Ile Ala Lys Ser 3500 3505 3510 Val Phe Asp Arg Asp Leu Ala Val Gln Lys Lys Leu Asp Ser Met 3515 3520 3525 Ala Glu Arg Ala Met Thr Thr Met Tyr Lys Glu Ala Arg Val Thr 3530 3535 3540 Asp Arg Arg Ala Lys Leu Val Ser Ser Leu His Ala Leu Leu Phe 3545 3550 3555 Ser Met Leu Lys Lys Ile Asp Ser Glu Lys Leu Asn Val Leu Phe 3560 3565 3570 Asp Gln Ala Ser Ser Gly Val Val Pro Leu Ala Thr Val Pro Ile 3575 3580 3585 Val Cys Ser Asn Lys Leu Thr Leu Val Ile Pro Asp Pro Glu Thr 3590 3595 3600 Trp Val Lys Cys Val Glu Gly Val His Val Thr Tyr Ser Thr Val 3605 3610 3615 Val Trp Asn Ile Asp Thr Val Ile Asp Ala Asp Gly Thr Glu Leu 3620 3625 3630 His Pro Thr Ser Thr Gly Ser Gly Leu Thr Tyr Cys Ile Ser Gly 3635 3640 3645 Ala Asn Ile Ala Trp Pro Leu Lys Val Asn Leu Thr Arg Asn Gly 3650 3655 3660 His Asn Lys Val Asp Val Val Leu Gln Asn Asn Glu Leu Met Pro 3665 3670 3675 His Gly Val Lys Thr Lys Ala Cys Val Ala Gly Val Asp Gln Ala 3680 3685 3690 His Cys Ser Val Glu Ser Lys Cys Tyr Tyr Thr Asn Ile Ser Gly 3695 3700 3705 Asn Ser Val Val Ala Ala Ile Thr Ser Ser Asn Pro Asn Leu Lys 3710 3715 3720 Val Ala Ser Phe Leu Asn Glu Ala Gly Asn Gln Ile Tyr Val Asp 3725 3730 3735 Leu Asp Pro Pro Cys Lys Phe Gly Met Lys Val Gly Val Lys Val 3740 3745 3750 Glu Val Val Tyr Leu Tyr Phe Ile Lys Asn Thr Arg Ser Ile Val 3755 3760 3765 Arg Gly Met Val Leu Gly Ala Ile Ser Asn Val Val Val Leu Gln 3770 3775 3780 Ser Lys Gly His Glu Thr Glu Glu Val Asp Ala Val Gly Ile Leu 3785 3790 3795 Ser Leu Cys Ser Phe Ala Val Asp Pro Ala Asp Thr Tyr Cys Lys 3800 3805 3810 Tyr Val Ala Ala Gly Asn Gln Pro Leu Gly Asn Cys Val Lys Met 3815 3820 3825 Leu Thr Val His Asn Gly Ser Gly Phe Ala Ile Thr Ser Lys Pro 3830 3835 3840 Ser Pro Thr Pro Asp Gln Asp Ser Tyr Gly Gly Ala Ser Val Cys 3845 3850 3855 Leu Tyr Cys Arg Ala His Ile Ala His Pro Gly Ser Val Gly Asn 3860 3865 3870 Leu Asp Gly Arg Cys Gln Phe Lys Gly Ser Phe Val Gln Ile Pro 3875 3880 3885 Thr Thr Glu Lys Asp Pro Val Gly Phe Cys Leu Arg Asn Lys Val 3890 3895 3900 Cys Thr Val Cys Gln Cys Trp Ile Gly Tyr Gly Cys Gln Cys Asp 3905 3910 3915 Ser Leu Arg Gln Pro Lys Ser Ser Val Gln Ser Val Ala Gly Ala 3920 3925 3930 Ser Asp Phe Asp Lys Asn Tyr Leu Asn Gly Tyr Gly Val Ala Val 3935 3940 3945 Arg Leu Gly 3950 <210> 12 <211> 4085 <212> PRT <213> human coronavirsu 229E <220> <221> MISC_FEATURE <223> ORF 1A <400> 12 Met Ala Cys Asn Arg Val Thr Leu Ala Val Ala Ser Asp Ser Glu Ile 1 5 10 15 Ser Ala Asn Gly Cys Ser Thr Ile Ala Gln Ala Val Arg Arg Tyr Ser 20 25 30 Glu Ala Ala Ser Asn Gly Phe Arg Ala Cys Arg Phe Val Ser Leu Asp 35 40 45 Leu Gln Asp Cys Ile Val Gly Ile Ala Asp Asp Thr Tyr Val Met Gly 50 55 60 Leu His Gly Asn Gln Thr Leu Phe Cys Asn Ile Met Lys Phe Ser Asp 65 70 75 80 Arg Pro Phe Met Leu His Gly Trp Leu Val Phe Ser Asn Ser Asn Tyr 85 90 95 Leu Leu Glu Glu Phe Asp Val Val Phe Gly Lys Arg Gly Gly Gly Asn 100 105 110 Val Thr Tyr Thr Asp Gln Tyr Leu Cys Gly Ala Asp Gly Lys Pro Val 115 120 125 Met Ser Glu Asp Leu Trp Gln Phe Val Asp His Phe Gly Glu Asn Glu 130 135 140 Glu Ile Ile Ile Asn Gly His Thr Tyr Val Cys Ala Trp Leu Thr Lys 145 150 155 160 Arg Lys Pro Leu Asp Tyr Lys Arg Gln Asn Asn Leu Ala Ile Glu Glu 165 170 175 Ile Glu Tyr Val His Gly Asp Ala Leu His Thr Leu Arg Asn Gly Ser 180 185 190 Val Leu Glu Met Ala Lys Glu Val Lys Thr Ser Ser Lys Val Val Leu 195 200 205 Ser Asp Ala Leu Asp Lys Leu Tyr Lys Val Phe Gly Ser Pro Val Met 210 215 220 Thr Asn Gly Ser Asn Ile Leu Glu Ala Phe Thr Lys Pro Val Phe Ile 225 230 235 240 Ser Ala Leu Val Gln Cys Thr Cys Gly Thr Lys Ser Trp Ser Val Gly 245 250 255 Asp Trp Thr Gly Phe Lys Ser Ser Cys Cys Asn Val Ile Ser Asn Lys 260 265 270 Leu Cys Val Val Pro Gly Asn Val Lys Pro Gly Asp Ala Val Ile Thr 275 280 285 Thr Gln Gln Ala Gly Ala Gly Ile Lys Tyr Phe Cys Gly Met Thr Leu 290 295 300 Lys Phe Val Ala Asn Ile Glu Gly Val Ser Val Trp Arg Val Ile Ala 305 310 315 320 Leu Gln Ser Val Asp Cys Phe Val Ala Ser Ser Thr Phe Val Glu Glu 325 330 335 Glu His Val Asn Arg Met Asp Thr Phe Cys Phe Asn Val Arg Asn Ser 340 345 350 Val Thr Asp Glu Cys Arg Leu Ala Met Leu Gly Ala Glu Met Thr Ser 355 360 365 Asn Val Arg Arg Gln Val Ala Ser Gly Val Ile Asp Ile Ser Thr Gly 370 375 380 Trp Phe Asp Val Tyr Asp Asp Ile Phe Ala Glu Ser Lys Pro Trp Phe 385 390 395 400 Val Arg Lys Ala Glu Asp Ile Phe Gly Pro Cys Trp Ser Ala Leu Ala 405 410 415 Ser Ala Leu Lys Gln Leu Lys Val Thr Thr Gly Glu Leu Val Arg Phe 420 425 430 Val Lys Ser Ile Cys Asn Ser Ala Val Ala Val Val Gly Gly Thr Ile 435 440 445 Gln Ile Leu Ala Ser Val Pro Glu Lys Phe Leu Asn Ala Phe Asp Val 450 455 460 Phe Val Thr Ala Ile Gln Thr Val Phe Asp Cys Ala Val Glu Thr Cys 465 470 475 480 Thr Ile Ala Gly Lys Ala Phe Asp Lys Val Phe Asp Tyr Val Leu Leu 485 490 495 Asp Asn Ala Leu Val Lys Leu Val Thr Thr Lys Leu Lys Gly Val Arg 500 505 510 Glu Arg Gly Leu Asn Lys Val Lys Tyr Ala Thr Val Val Val Gly Ser 515 520 525 Thr Glu Glu Val Lys Ser Ser Arg Val Glu Arg Ser Thr Ala Val Leu 530 535 540 Thr Ile Ala Asn Asn Tyr Ser Lys Leu Phe Asp Glu Gly Tyr Thr Val 545 550 555 560 Val Ile Gly Asp Val Ala Tyr Phe Val Ser Asp Gly Tyr Phe Arg Leu 565 570 575 Met Ala Ser Pro Asn Ser Val Leu Thr Thr Ala Val Tyr Lys Pro Leu 580 585 590 Phe Ala Phe Asn Val Asn Val Met Gly Thr Arg Pro Glu Lys Phe Pro 595 600 605 Thr Thr Val Thr Cys Glu Asn Leu Glu Ser Ala Val Leu Phe Val Asn 610 615 620 Asp Lys Ile Thr Glu Phe Gln Leu Asp Tyr Ser Ile Asp Val Ile Asp 625 630 635 640 Asn Glu Ile Ile Val Lys Pro Asn Ile Ser Leu Cys Val Pro Leu Tyr 645 650 655 Val Arg Asp Tyr Val Asp Lys Trp Asp Asp Phe Cys Arg Gln Tyr Ser 660 665 670 Asn Glu Ser Trp Phe Glu Asp Asp Tyr Arg Ala Phe Ile Ser Val Leu 675 680 685 Asp Ile Thr Asp Ala Ala Val Lys Ala Ala Glu Ser Lys Ala Phe Val 690 695 700 Asp Thr Ile Val Pro Pro Cys Pro Ser Ile Leu Lys Val Ile Asp Gly 705 710 715 720 Gly Lys Ile Trp Asn Gly Val Ile Lys Asn Val Asn Ser Val Arg Asp 725 730 735 Trp Leu Lys Ser Leu Lys Leu Asn Leu Thr Gln Gln Gly Leu Leu Gly 740 745 750 Thr Cys Ala Lys Arg Phe Lys Arg Trp Leu Gly Ile Leu Leu Glu Ala 755 760 765 Tyr Asn Ala Phe Leu Asp Thr Val Val Ser Thr Val Lys Ile Gly Gly 770 775 780 Leu Thr Phe Lys Thr Tyr Ala Phe Asp Lys Pro Tyr Ile Val Ile Arg 785 790 795 800 Asp Ile Val Cys Lys Val Glu Asn Lys Thr Glu Ala Glu Trp Ile Glu 805 810 815 Leu Phe Pro His Asn Asp Arg Ile Lys Ser Phe Ser Thr Phe Glu Ser 820 825 830 Ala Tyr Met Pro Ile Ala Asp Pro Thr His Phe Asp Ile Glu Glu Val 835 840 845 Glu Leu Leu Asp Ala Glu Phe Val Glu Pro Gly Cys Gly Gly Ile Leu 850 855 860 Ala Val Ile Asp Glu His Val Phe Tyr Lys Lys Asp Gly Val Tyr Tyr 865 870 875 880 Pro Ser Asn Gly Thr Asn Ile Leu Pro Val Ala Phe Thr Lys Ala Ala 885 890 895 Gly Gly Lys Val Ser Phe Ser Asp Asp Val Glu Val Lys Asp Ile Glu 900 905 910 Pro Val Tyr Arg Val Lys Leu Cys Phe Glu Phe Glu Asp Glu Lys Leu 915 920 925 Val Asp Val Cys Glu Lys Ala Ile Gly Lys Lys Ile Lys His Glu Gly 930 935 940 Asp Trp Asp Ser Phe Cys Lys Thr Ile Gln Ser Ala Leu Ser Val Val 945 950 955 960 Ser Cys Tyr Val Asn Leu Pro Thr Tyr Tyr Ile Tyr Asp Glu Glu Gly 965 970 975 Gly Asn Asp Leu Ser Leu Pro Val Met Ile Ser Glu Trp Pro Leu Ser 980 985 990 Val Gln Gln Ala Gln Gln Glu Ala Thr Leu Pro Asp Ile Ala Glu Asp 995 1000 1005 Val Val Asp Gln Val Glu Glu Val Asn Ser Ile Phe Asp Ile Glu 1010 1015 1020 Thr Val Asp Val Lys His Asp Val Ser Pro Phe Glu Met Pro Phe 1025 1030 1035 Glu Glu Leu Asn Gly Leu Lys Ile Leu Lys Gln Leu Asp Asn Asn 1040 1045 1050 Cys Trp Val Asn Ser Val Met Leu Gln Ile Gln Leu Thr Gly Ile 1055 1060 1065 Leu Asp Gly Asp Tyr Ala Met Gln Phe Phe Lys Met Gly Arg Val 1070 1075 1080 Ala Lys Met Ile Glu Arg Cys Tyr Thr Ala Glu Gln Cys Ile Arg 1085 1090 1095 Gly Ala Met Gly Asp Val Gly Leu Cys Met Tyr Arg Leu Leu Lys 1100 1105 1110 Asp Leu His Thr Gly Phe Met Val Met Asp Tyr Lys Cys Ser Cys 1115 1120 1125 Thr Ser Gly Arg Leu Glu Glu Ser Gly Ala Val Leu Phe Cys Thr 1130 1135 1140 Pro Thr Lys Lys Ala Phe Pro Tyr Gly Thr Cys Leu Asn Cys Asn 1145 1150 1155 Ala Pro Arg Met Cys Thr Ile Arg Gln Leu Gln Gly Thr Ile Ile 1160 1165 1170 Phe Val Gln Gln Lys Pro Glu Pro Val Asn Pro Val Ser Phe Val 1175 1180 1185 Val Lys Pro Val Cys Ser Ser Ile Phe Arg Gly Ala Val Ser Cys 1190 1195 1200 Gly His Tyr Gln Thr Asn Ile Tyr Ser Gln Asn Leu Cys Val Asp 1205 1210 1215 Gly Phe Gly Val Asn Lys Ile Gln Pro Trp Thr Asn Asp Ala Leu 1220 1225 1230 Asn Thr Ile Cys Ile Lys Asp Ala Asp Tyr Asn Ala Lys Val Glu 1235 1240 1245 Ile Ser Val Thr Pro Ile Lys Asn Thr Val Asp Thr Thr Pro Lys 1250 1255 1260 Glu Glu Phe Val Val Lys Glu Lys Leu Asn Ala Phe Leu Val His 1265 1270 1275 Asp Asn Val Ala Phe Tyr Gln Gly Asp Val Asp Thr Val Val Asn 1280 1285 1290 Gly Val Asp Phe Asp Phe Ile Val Asn Ala Ala Asn Glu Asn Leu 1295 1300 1305 Ala His Gly Gly Gly Leu Ala Lys Ala Leu Asp Val Tyr Thr Lys 1310 1315 1320 Gly Lys Leu Gln Arg Leu Ser Lys Glu His Ile Gly Leu Ala Gly 1325 1330 1335 Lys Val Lys Val Gly Thr Gly Val Met Val Glu Cys Asp Ser Leu 1340 1345 1350 Arg Ile Phe Asn Val Val Gly Pro Arg Lys Gly Lys His Glu Arg 1355 1360 1365 Asp Leu Leu Ile Lys Ala Tyr Asn Thr Ile Asn Asn Glu Gln Gly 1370 1375 1380 Thr Pro Leu Thr Pro Ile Leu Ser Cys Gly Ile Phe Gly Ile Lys 1385 1390 1395 Leu Glu Thr Ser Leu Glu Val Leu Leu Asp Val Cys Asn Thr Lys 1400 1405 1410 Glu Val Lys Val Phe Val Tyr Thr Asp Thr Glu Val Cys Lys Val 1415 1420 1425 Lys Asp Phe Val Ser Gly Leu Val Asn Val Gln Lys Val Glu Gln 1430 1435 1440 Pro Lys Ile Glu Pro Lys Pro Val Ser Val Ile Lys Val Ala Pro 1445 1450 1455 Lys Pro Tyr Arg Val Asp Gly Lys Phe Ser Tyr Phe Thr Glu Asp 1460 1465 1470 Leu Leu Cys Val Ala Asp Asp Lys Pro Ile Val Leu Phe Thr Asp 1475 1480 1485 Ser Met Leu Thr Leu Asp Asp Arg Gly Leu Ala Leu Asp Asn Ala 1490 1495 1500 Leu Ser Gly Val Leu Ser Ala Ala Ile Lys Asp Cys Val Asp Ile 1505 1510 1515 Asn Lys Ala Ile Pro Ser Gly Asn Leu Ile Lys Phe Asp Ile Gly 1520 1525 1530 Ser Val Val Val Tyr Met Cys Val Val Pro Ser Glu Lys Asp Lys 1535 1540 1545 His Leu Asp Asn Asn Val Gln Arg Cys Thr Arg Lys Leu Asn Arg 1550 1555 1560 Leu Met Cys Asp Ile Val Cys Thr Ile Pro Ala Asp Tyr Ile Leu 1565 1570 1575 Pro Leu Val Leu Ser Ser Leu Thr Cys Asn Val Ser Phe Val Gly 1580 1585 1590 Glu Leu Lys Ala Ala Glu Ala Lys Val Ile Thr Ile Lys Val Thr 1595 1600 1605 Glu Asp Gly Val Asn Val His Asp Val Thr Val Thr Thr Asp Lys 1610 1615 1620 Ser Phe Glu Gln Gln Val Gly Val Ile Ala Asp Lys Asp Lys Asp 1625 1630 1635 Leu Ser Gly Ala Val Pro Ser Asp Leu Asn Thr Ser Glu Leu Leu 1640 1645 1650 Thr Lys Ala Ile Asp Val Asp Trp Val Glu Phe Tyr Gly Phe Lys 1655 1660 1665 Asp Ala Val Thr Phe Ala Thr Val Asp His Ser Ala Phe Ala Tyr 1670 1675 1680 Glu Ser Ala Val Val Asn Gly Ile Arg Val Leu Lys Thr Ser Asp 1685 1690 1695 Asn Asn Cys Trp Val Asn Ala Val Cys Ile Ala Leu Gln Tyr Ser 1700 1705 1710 Lys Pro His Phe Ile Ser Gln Gly Leu Asp Ala Ala Trp Asn Lys 1715 1720 1725 Phe Val Leu Gly Asp Val Glu Ile Phe Val Ala Phe Val Tyr Tyr 1730 1735 1740 Val Ala Arg Leu Met Lys Gly Asp Lys Gly Asp Ala Glu Asp Thr 1745 1750 1755 Leu Thr Lys Leu Ser Lys Tyr Leu Ala Asn Glu Ala Gln Val Gln 1760 1765 1770 Leu Glu His Tyr Ser Ser Cys Val Glu Cys Asp Ala Lys Phe Lys 1775 1780 1785 Asn Ser Val Ala Ser Ile Asn Ser Ala Ile Val Cys Ala Ser Val 1790 1795 1800 Lys Arg Asp Gly Val Gln Val Gly Tyr Cys Val His Gly Ile Lys 1805 1810 1815 Tyr Tyr Ser Arg Val Arg Ser Val Arg Gly Arg Ala Ile Ile Val 1820 1825 1830 Ser Val Glu Gln Leu Glu Pro Cys Ala Gln Ser Arg Leu Leu Ser 1835 1840 1845 Gly Val Ala Tyr Thr Ala Phe Ser Gly Pro Val Asp Lys Gly His 1850 1855 1860 Tyr Thr Val Tyr Asp Thr Ala Lys Lys Ser Met Tyr Asp Gly Asp 1865 1870 1875 Arg Phe Val Lys His Asp Leu Ser Leu Leu Ser Val Thr Ser Val 1880 1885 1890 Val Met Val Gly Gly Tyr Val Ala Pro Val Asn Thr Val Lys Pro 1895 1900 1905 Lys Pro Val Ile Asn Gln Leu Asp Glu Lys Ala Gln Lys Phe Phe 1910 1915 1920 Asp Phe Gly Asp Phe Leu Ile His Asn Phe Val Ile Phe Phe Thr 1925 1930 1935 Trp Leu Leu Ser Met Phe Thr Leu Cys Lys Thr Ala Val Thr Thr 1940 1945 1950 Gly Asp Val Lys Ile Met Ala Lys Ala Pro Gln Arg Thr Gly Val 1955 1960 1965 Val Leu Lys Arg Ser Leu Lys Tyr Asn Leu Lys Ala Ser Ala Ala 1970 1975 1980 Val Leu Lys Ser Lys Trp Trp Leu Leu Ala Lys Phe Thr Lys Leu 1985 1990 1995 Leu Leu Leu Ile Tyr Thr Leu Tyr Ser Val Val Leu Leu Cys Val 2000 2005 2010 Arg Phe Gly Pro Phe Asn Phe Cys Ser Glu Thr Val Asn Gly Tyr 2015 2020 2025 Ala Lys Ser Asn Phe Val Lys Asp Asp Tyr Cys Asp Gly Ser Leu 2030 2035 2040 Gly Cys Lys Met Cys Leu Phe Gly Tyr Gln Glu Leu Ser Gln Phe 2045 2050 2055 Ser His Leu Asp Val Val Trp Lys His Ile Thr Asp Pro Leu Phe 2060 2065 2070 Ser Asn Met Gln Pro Phe Ile Val Met Val Leu Leu Leu Ile Phe 2075 2080 2085 Gly Asp Asn Tyr Leu Arg Cys Phe Leu Leu Tyr Phe Val Ala Gln 2090 2095 2100 Met Ile Ser Thr Val Gly Val Phe Leu Gly Tyr Lys Glu Thr Asn 2105 2110 2115 Trp Phe Leu His Phe Ile Pro Phe Asp Val Ile Cys Asp Glu Leu 2120 2125 2130 Leu Val Thr Val Ile Val Ile Lys Val Ile Ser Phe Val Arg His 2135 2140 2145 Val Leu Phe Gly Cys Glu Asn Pro Asp Cys Ile Ala Cys Ser Lys 2150 2155 2160 Ser Ala Arg Leu Lys Arg Phe Pro Val Asn Thr Ile Val Asn Gly 2165 2170 2175 Val Gln Arg Ser Phe Tyr Val Asn Ala Asn Gly Gly Ser Lys Phe 2180 2185 2190 Cys Lys Lys His Arg Phe Phe Cys Val Asp Cys Asp Ser Tyr Gly 2195 2200 2205 Tyr Gly Ser Thr Phe Ile Thr Pro Glu Val Ser Arg Glu Leu Gly 2210 2215 2220 Asn Ile Thr Lys Thr Asn Val Gln Pro Thr Gly Pro Ala Tyr Val 2225 2230 2235 Met Ile Asp Lys Val Glu Phe Glu Asn Gly Phe Tyr Arg Leu Tyr 2240 2245 2250 Ser Cys Glu Thr Phe Trp Arg Tyr Asn Phe Asp Ile Thr Glu Ser 2255 2260 2265 Lys Tyr Ser Cys Lys Glu Val Phe Lys Asn Cys Asn Val Leu Asp 2270 2275 2280 Asp Phe Ile Val Phe Asn Asn Asn Gly Thr Asn Val Thr Gln Val 2285 2290 2295 Lys Asn Ala Ser Val Tyr Phe Ser Gln Leu Leu Cys Arg Pro Ile 2300 2305 2310 Lys Leu Val Asp Ser Glu Leu Leu Ser Thr Leu Ser Val Asp Phe 2315 2320 2325 Asn Gly Val Leu His Lys Ala Tyr Ile Asp Val Leu Arg Asn Ser 2330 2335 2340 Phe Gly Lys Asp Leu Asn Ala Asn Met Ser Leu Ala Glu Cys Lys 2345 2350 2355 Arg Ala Leu Gly Leu Ser Ile Ser Asp His Glu Phe Thr Ser Ala 2360 2365 2370 Ile Ser Asn Ala His Arg Cys Asp Val Leu Leu Ser Asp Leu Ser 2375 2380 2385 Phe Asn Asn Phe Val Ser Ser Tyr Ala Lys Pro Glu Glu Lys Leu 2390 2395 2400 Ser Ala Tyr Asp Leu Ala Cys Cys Met Arg Ala Gly Ala Lys Val 2405 2410 2415 Val Asn Ala Asn Val Leu Thr Lys Asp Gln Thr Pro Ile Val Trp 2420 2425 2430 His Ala Lys Asp Phe Asn Ser Leu Ser Ala Glu Gly Arg Lys Tyr 2435 2440 2445 Ile Val Lys Thr Ser Lys Ala Lys Gly Leu Thr Phe Leu Leu Thr 2450 2455 2460 Ile Asn Glu Asn Gln Ala Val Thr Gln Ile Pro Ala Thr Ser Ile 2465 2470 2475 Val Ala Lys Gln Gly Ala Gly Asp Ala Gly His Ser Leu Thr Trp 2480 2485 2490 Leu Trp Leu Leu Cys Gly Leu Val Cys Leu Ile Gln Phe Tyr Leu 2495 2500 2505 Cys Phe Phe Met Pro Tyr Phe Met Tyr Asp Ile Val Ser Ser Phe 2510 2515 2520 Glu Gly Tyr Asp Phe Lys Tyr Ile Glu Asn Gly Gln Leu Lys Asn 2525 2530 2535 Phe Glu Ala Pro Leu Lys Cys Val Arg Asn Val Phe Glu Asn Phe 2540 2545 2550 Glu Asp Trp His Tyr Ala Lys Phe Gly Phe Thr Pro Leu Asn Lys 2555 2560 2565 Gln Ser Cys Pro Ile Val Val Gly Val Ser Glu Ile Val Asn Thr 2570 2575 2580 Val Ala Gly Ile Pro Ser Asn Val Tyr Leu Val Gly Lys Thr Leu 2585 2590 2595 Ile Phe Thr Leu Gln Ala Ala Phe Gly Asn Ala Gly Val Cys Tyr 2600 2605 2610 Asp Ile Phe Gly Val Thr Thr Pro Glu Lys Cys Ile Phe Thr Ser 2615 2620 2625 Ala Cys Thr Arg Leu Glu Gly Leu Gly Gly Asn Asn Val Tyr Cys 2630 2635 2640 Tyr Asn Thr Ala Leu Met Glu Gly Ser Leu Pro Tyr Ser Ser Ile 2645 2650 2655 Gln Ala Asn Ala Tyr Tyr Lys Tyr Asp Asn Gly Asn Phe Ile Lys 2660 2665 2670 Leu Pro Glu Val Ile Ala Gln Gly Phe Gly Phe Arg Thr Val Arg 2675 2680 2685 Thr Ile Ala Thr Lys Tyr Cys Arg Val Gly Glu Cys Val Glu Ser 2690 2695 2700 Asn Ala Gly Val Cys Phe Gly Phe Asp Lys Trp Phe Val Asn Asp 2705 2710 2715 Gly Arg Val Ala Asn Gly Tyr Val Cys Gly Thr Gly Leu Trp Asn 2720 2725 2730 Leu Val Phe Asn Ile Leu Ser Met Phe Ser Ser Ser Phe Ser Val 2735 2740 2745 Ala Ala Met Ser Gly Gln Ile Leu Leu Asn Cys Ala Leu Gly Ala 2750 2755 2760 Phe Ala Ile Phe Cys Cys Phe Leu Val Thr Lys Phe Arg Arg Met 2765 2770 2775 Phe Gly Asp Leu Ser Val Gly Val Cys Thr Val Val Val Ala Val 2780 2785 2790 Leu Leu Asn Asn Val Ser Tyr Ile Val Thr Gln Asn Leu Val Thr 2795 2800 2805 Met Ile Ala Tyr Ala Ile Leu Tyr Phe Phe Ala Thr Arg Ser Leu 2810 2815 2820 Arg Tyr Ala Trp Ile Trp Cys Ala Ala Tyr Leu Ile Ala Tyr Ile 2825 2830 2835 Ser Phe Ala Pro Trp Trp Leu Cys Ala Trp Tyr Phe Leu Ala Met 2840 2845 2850 Leu Thr Gly Leu Leu Pro Ser Leu Leu Lys Leu Lys Val Ser Thr 2855 2860 2865 Asn Leu Phe Glu Gly Asp Lys Phe Val Gly Thr Phe Glu Ser Ala 2870 2875 2880 Ala Ala Gly Thr Phe Val Ile Asp Met Arg Ser Tyr Glu Lys Leu 2885 2890 2895 Ala Asn Ser Ile Ser Pro Glu Lys Leu Lys Ser Tyr Ala Ala Ser 2900 2905 2910 Tyr Asn Arg Tyr Lys Tyr Tyr Ser Gly Asn Ala Asn Glu Ala Asp 2915 2920 2925 Tyr Arg Cys Ala Cys Tyr Ala Tyr Leu Ala Lys Ala Met Leu Asp 2930 2935 2940 Phe Ser Arg Asp His Asn Asp Ile Leu Tyr Thr Pro Pro Thr Val 2945 2950 2955 Ser Tyr Gly Ser Thr Leu Gln Ala Gly Leu Arg Lys Met Ala Gln 2960 2965 2970 Pro Ser Gly Phe Val Glu Lys Cys Val Val Arg Val Cys Tyr Gly 2975 2980 2985 Asn Thr Val Leu Asn Gly Leu Trp Leu Gly Asp Ile Val Tyr Cys 2990 2995 3000 Pro Arg His Val Ile Ala Ser Asn Thr Thr Ser Ala Ile Asp Tyr 3005 3010 3015 Asp His Glu Tyr Ser Ile Met Arg Leu His Asn Phe Ser Ile Ile 3020 3025 3030 Ser Gly Thr Ala Phe Leu Gly Val Val Gly Ala Thr Met His Gly 3035 3040 3045 Val Thr Leu Lys Ile Lys Val Ser Gln Thr Asn Met His Thr Pro 3050 3055 3060 Arg His Ser Phe Arg Thr Leu Lys Ser Gly Glu Gly Phe Asn Ile 3065 3070 3075 Leu Ala Cys Tyr Asp Gly Cys Ala Gln Gly Val Phe Gly Val Asn 3080 3085 3090 Met Arg Thr Asn Trp Thr Ile Arg Gly Ser Phe Ile Asn Gly Ala 3095 3100 3105 Cys Gly Ser Pro Gly Tyr Asn Leu Lys Asn Gly Glu Val Glu Phe 3110 3115 3120 Val Tyr Met His Gln Ile Glu Leu Gly Ser Gly Ser His Val Gly 3125 3130 3135 Ser Ser Phe Asp Gly Val Met Tyr Gly Gly Phe Glu Asp Gln Pro 3140 3145 3150 Asn Leu Gln Val Glu Ser Ala Asn Gln Met Leu Thr Val Asn Val 3155 3160 3165 Val Ala Phe Leu Tyr Ala Ala Ile Leu Asn Gly Cys Thr Trp Trp 3170 3175 3180 Leu Lys Gly Glu Lys Leu Phe Val Glu His Tyr Asn Glu Trp Ala 3185 3190 3195 Gln Ala Asn Gly Phe Thr Ala Met Asn Gly Glu Asp Ala Phe Ser 3200 3205 3210 Ile Leu Ala Ala Lys Thr Gly Val Cys Val Glu Arg Leu Leu His 3215 3220 3225 Ala Ile Gln Val Leu Asn Asn Gly Phe Gly Gly Lys Gln Ile Leu 3230 3235 3240 Gly Tyr Ser Ser Leu Asn Asp Glu Phe Ser Ile Asn Glu Val Val 3245 3250 3255 Lys Gln Met Phe Gly Val Asn Leu Gln Ser Gly Lys Thr Thr Ser 3260 3265 3270 Met Phe Lys Ser Ile Ser Leu Phe Ala Gly Phe Phe Val Met Phe 3275 3280 3285 Trp Ala Glu Leu Phe Val Tyr Thr Thr Thr Ile Trp Val Asn Pro 3290 3295 3300 Gly Phe Leu Thr Pro Phe Met Ile Leu Leu Val Ala Leu Ser Leu 3305 3310 3315 Cys Leu Thr Phe Val Val Lys His Lys Val Leu Phe Leu Gln Val 3320 3325 3330 Phe Leu Leu Pro Ser Ile Ile Val Ala Ala Ile Gln Asn Cys Ala 3335 3340 3345 Trp Asp Tyr His Val Thr Lys Val Leu Ala Glu Lys Phe Asp Tyr 3350 3355 3360 Asn Val Ser Val Met Gln Met Asp Ile Gln Gly Phe Val Asn Ile 3365 3370 3375 Phe Ile Cys Leu Phe Val Ala Leu Leu His Thr Trp Arg Phe Ala 3380 3385 3390 Lys Glu Arg Cys Thr His Trp Cys Thr Tyr Leu Phe Ser Leu Ile 3395 3400 3405 Ala Val Leu Tyr Thr Ala Leu Tyr Ser Tyr Asp Tyr Val Ser Leu 3410 3415 3420 Leu Val Met Leu Leu Cys Ala Ile Ser Asn Glu Trp Tyr Ile Gly 3425 3430 3435 Ala Ile Ile Phe Arg Ile Cys Arg Phe Gly Val Ala Phe Leu Pro 3440 3445 3450 Val Glu Tyr Val Ser Tyr Phe Asp Gly Val Lys Thr Val Leu Leu 3455 3460 3465 Phe Tyr Met Leu Leu Gly Phe Val Ser Cys Met Tyr Tyr Gly Leu 3470 3475 3480 Leu Tyr Trp Ile Asn Arg Phe Cys Lys Cys Thr Leu Gly Val Tyr 3485 3490 3495 Asp Phe Cys Val Ser Pro Ala Glu Phe Lys Tyr Met Val Ala Asn 3500 3505 3510 Gly Leu Asn Ala Pro Asn Gly Pro Phe Asp Ala Leu Phe Leu Ser 3515 3520 3525 Phe Lys Leu Met Gly Ile Gly Gly Pro Arg Thr Ile Lys Val Ser 3530 3535 3540 Thr Val Gln Ser Lys Leu Thr Asp Leu Lys Cys Thr Asn Val Val 3545 3550 3555 Leu Met Gly Ile Leu Ser Asn Met Asn Ile Ala Ser Asn Ser Lys 3560 3565 3570 Glu Trp Ala Tyr Cys Val Glu Met His Asn Lys Ile Asn Leu Cys 3575 3580 3585 Asp Asp Pro Glu Thr Ala Gln Glu Leu Leu Leu Ala Leu Leu Ala 3590 3595 3600 Phe Phe Leu Ser Lys His Ser Asp Phe Gly Leu Gly Asp Leu Val 3605 3610 3615 Asp Ser Tyr Phe Glu Asn Asp Ser Ile Leu Gln Ser Val Ala Ser 3620 3625 3630 Ser Phe Val Gly Met Pro Ser Phe Val Ala Tyr Glu Thr Ala Arg 3635 3640 3645 Gln Glu Tyr Glu Asn Ala Val Ala Asn Gly Ser Ser Pro Gln Ile 3650 3655 3660 Ile Lys Gln Leu Lys Lys Ala Met Asn Val Ala Lys Ala Glu Phe 3665 3670 3675 Asp Arg Glu Ser Ser Val Gln Lys Lys Ile Asn Arg Met Ala Glu 3680 3685 3690 Gln Ala Ala Ala Ala Met Tyr Lys Glu Ala Arg Ala Val Asn Arg 3695 3700 3705 Lys Ser Lys Val Val Ser Ala Met His Ser Leu Leu Phe Gly Met 3710 3715 3720 Leu Arg Arg Leu Asp Met Ser Ser Val Asp Thr Ile Leu Asn Met 3725 3730 3735 Ala Arg Asn Gly Val Val Pro Leu Ser Val Ile Pro Ala Thr Ser 3740 3745 3750 Ala Ala Arg Leu Val Val Val Val Pro Asp His Asp Ser Phe Val 3755 3760 3765 Lys Met Met Val Asp Gly Phe Val His Tyr Ala Gly Val Val Trp 3770 3775 3780 Thr Leu Gln Glu Val Lys Asp Asn Asp Gly Lys Asn Val His Leu 3785 3790 3795 Lys Asp Val Thr Lys Glu Asn Gln Glu Ile Leu Val Trp Pro Leu 3800 3805 3810 Ile Leu Thr Cys Glu Arg Val Val Lys Leu Gln Asn Asn Glu Ile 3815 3820 3825 Met Pro Gly Lys Met Lys Val Lys Ala Thr Lys Gly Glu Gly Asp 3830 3835 3840 Gly Gly Ile Thr Ser Glu Gly Asn Ala Leu Tyr Asn Asn Glu Gly 3845 3850 3855 Gly Arg Ala Phe Met Tyr Ala Tyr Val Thr Thr Lys Pro Gly Met 3860 3865 3870 Lys Tyr Val Lys Trp Glu His Asp Ser Gly Val Val Thr Val Glu 3875 3880 3885 Leu Glu Pro Pro Cys Arg Phe Val Ile Asp Thr Pro Thr Gly Pro 3890 3895 3900 Gln Ile Lys Tyr Leu Tyr Phe Val Lys Asn Leu Asn Asn Leu Arg 3905 3910 3915 Arg Gly Ala Val Leu Gly Tyr Ile Gly Ala Thr Val Arg Leu Gln 3920 3925 3930 Ala Gly Lys Gln Thr Glu Phe Val Ser Asn Ser His Leu Leu Thr 3935 3940 3945 His Cys Ser Phe Ala Val Asp Pro Ala Ala Ala Tyr Leu Asp Ala 3950 3955 3960 Val Lys Gln Gly Ala Lys Pro Val Gly Asn Cys Val Lys Met Leu 3965 3970 3975 Thr Asn Gly Ser Gly Ser Gly Gln Ala Ile Thr Cys Thr Ile Asp 3980 3985 3990 Ser Asn Thr Thr Gln Asp Thr Tyr Gly Gly Ala Ser Val Cys Ile 3995 4000 4005 Tyr Cys Arg Ala His Val Ala His Pro Thr Met Asp Gly Phe Cys 4010 4015 4020 Gln Tyr Lys Gly Lys Trp Val Gln Val Pro Ile Gly Thr Asn Asp 4025 4030 4035 Pro Ile Arg Phe Cys Leu Glu Asn Thr Val Cys Lys Val Cys Gly 4040 4045 4050 Cys Trp Leu Asn His Gly Cys Thr Cys Asp Arg Thr Ala Ile Gln 4055 4060 4065 Ser Phe Asp Asn Ser Tyr Leu Asn Glu Ser Gly Ala Leu Val Pro 4070 4075 4080 Leu Asp 4085 <210> 13 <211> 4017 <212> PRT <213> transmissible gastroeneteritis virus <220> <221> MISC_FEATURE <223> ORF 1A <400> 13 Met Ser Ser Lys Gln Phe Lys Ile Leu Val Asn Glu Asp Tyr Gln Val 1 5 10 15 Asn Val Pro Ser Leu Pro Ile Arg Asp Val Leu Gln Glu Ile Lys Tyr 20 25 30 Cys Tyr Arg Asn Gly Phe Glu Gly Tyr Val Phe Val Pro Glu Tyr Cys 35 40 45 Arg Asp Leu Val Asp Cys Asp Arg Lys Asp His Tyr Val Ile Gly Val 50 55 60 Leu Gly Asn Gly Val Ser Asp Leu Lys Pro Val Leu Leu Thr Glu Pro 65 70 75 80 Ser Val Met Leu Gln Gly Phe Ile Val Arg Ala Asn Cys Asn Gly Val 85 90 95 Leu Glu Asp Phe Asp Leu Lys Ile Ala Arg Thr Gly Arg Gly Ala Ile 100 105 110 Tyr Val Asp Gln Tyr Met Cys Gly Ala Asp Gly Lys Pro Val Ile Glu 115 120 125 Gly Asp Phe Lys Asp Tyr Phe Gly Asp Glu Asp Ile Ile Glu Phe Glu 130 135 140 Gly Glu Glu Tyr His Cys Ala Trp Thr Thr Val Arg Asp Glu Lys Pro 145 150 155 160 Leu Asn Gln Gln Thr Leu Phe Thr Ile Gln Glu Ile Gln Tyr Asn Leu 165 170 175 Asp Ile Pro His Lys Leu Pro Asn Cys Ala Thr Arg His Val Ala Pro 180 185 190 Pro Val Lys Lys Asn Ser Lys Ile Val Leu Ser Glu Asp Tyr Lys Lys 195 200 205 Leu Tyr Asp Ile Phe Gly Ser Pro Phe Met Gly Asn Gly Asp Cys Leu 210 215 220 Ser Lys Cys Phe Asp Thr Leu His Phe Ile Ala Ala Thr Leu Arg Cys 225 230 235 240 Pro Cys Gly Ser Glu Ser Ser Gly Val Gly Asp Trp Thr Gly Phe Lys 245 250 255 Thr Ala Cys Cys Gly Leu Ser Gly Lys Val Lys Gly Val Thr Leu Gly 260 265 270 Asp Ile Lys Pro Gly Asp Ala Val Val Thr Ser Met Ser Ala Gly Lys 275 280 285 Gly Val Lys Phe Phe Ala Asn Cys Val Leu Gln Tyr Ala Gly Asp Val 290 295 300 Glu Gly Val Ser Ile Trp Lys Val Ile Lys Thr Phe Thr Val Asp Glu 305 310 315 320 Thr Val Cys Thr Pro Gly Phe Glu Gly Glu Leu Asn Asp Phe Ile Lys 325 330 335 Pro Glu Ser Lys Ser Leu Val Ala Cys Ser Val Lys Arg Ala Phe Ile 340 345 350 Thr Gly Asp Ile Asp Asp Ala Val His Asp Cys Ile Ile Thr Gly Lys 355 360 365 Leu Asp Leu Ser Thr Asn Leu Phe Gly Asn Val Gly Leu Leu Phe Lys 370 375 380 Lys Thr Pro Trp Phe Val Gln Lys Cys Gly Ala Leu Phe Val Asp Ala 385 390 395 400 Trp Lys Val Val Glu Glu Leu Cys Gly Ser Leu Thr Leu Thr Tyr Lys 405 410 415 Gln Ile Tyr Glu Val Val Ala Ser Leu Cys Thr Ser Ala Phe Thr Ile 420 425 430 Val Asn Tyr Lys Pro Thr Phe Val Val Pro Asp Asn Arg Val Lys Asp 435 440 445 Leu Val Asp Lys Cys Val Lys Val Leu Val Lys Ala Phe Asp Val Phe 450 455 460 Thr Gln Ile Ile Thr Ile Ala Gly Ile Glu Ala Lys Cys Phe Val Leu 465 470 475 480 Gly Ala Lys Tyr Leu Leu Phe Asn Asn Ala Leu Val Lys Leu Val Ser 485 490 495 Val Lys Ile Leu Gly Lys Lys Gln Lys Gly Leu Glu Cys Ala Phe Phe 500 505 510 Ala Thr Ser Leu Val Gly Ala Thr Val Asn Val Thr Pro Lys Arg Thr 515 520 525 Glu Thr Ala Thr Ile Ser Leu Asn Lys Val Asp Asp Val Val Ala Pro 530 535 540 Gly Glu Gly Tyr Ile Val Ile Val Gly Asp Met Ala Phe Tyr Lys Ser 545 550 555 560 Gly Glu Tyr Tyr Phe Met Met Ser Ser Pro Asn Phe Val Leu Thr Asn 565 570 575 Asn Val Phe Lys Ala Val Lys Val Pro Ser Tyr Asp Ile Val Tyr Asp 580 585 590 Val Asp Asn Asp Thr Lys Ser Lys Met Ile Ala Lys Leu Gly Ser Ser 595 600 605 Phe Glu Tyr Asp Gly Asp Ile Asp Ala Ala Ile Val Lys Val Asn Glu 610 615 620 Leu Leu Ile Glu Phe Arg Gln Gln Ser Leu Cys Phe Arg Ala Phe Lys 625 630 635 640 Asp Asp Lys Ser Ile Phe Val Glu Ala Tyr Phe Lys Lys Tyr Lys Met 645 650 655 Pro Ala Cys Leu Ala Lys His Ile Gly Leu Trp Asn Ile Ile Lys Lys 660 665 670 Asp Ser Cys Lys Arg Gly Phe Leu Asn Leu Phe Asn His Leu Asn Glu 675 680 685 Leu Glu Asp Ile Lys Glu Thr Asn Ile Gln Ala Ile Lys Asn Ile Leu 690 695 700 Cys Pro Asp Pro Leu Leu Asp Leu Asp Tyr Gly Ala Ile Trp Tyr Asn 705 710 715 720 Cys Met Pro Gly Cys Ser Asp Pro Ser Val Leu Gly Ser Val Gln Leu 725 730 735 Leu Ile Gly Asn Gly Val Lys Val Val Cys Asp Gly Cys Lys Gly Phe 740 745 750 Ala Asn Gln Leu Ser Lys Gly Tyr Asn Lys Leu Cys Asn Ala Ala Arg 755 760 765 Asn Asp Ile Glu Ile Gly Gly Ile Pro Phe Ser Thr Phe Lys Thr Pro 770 775 780 Thr Asn Thr Phe Ile Glu Met Thr Asp Ala Ile Tyr Ser Val Ile Glu 785 790 795 800 Gln Gly Lys Ala Leu Ser Phe Arg Asp Ala Asp Val Pro Val Val Asp 805 810 815 Asn Gly Thr Ile Ser Thr Ala Asp Trp Ser Glu Pro Ile Leu Leu Glu 820 825 830 Pro Ala Glu Tyr Val Lys Pro Lys Asn Asn Gly Asn Val Ile Val Ile 835 840 845 Ala Gly Tyr Thr Phe Tyr Lys Asp Glu Asp Glu His Phe Tyr Pro Tyr 850 855 860 Gly Phe Gly Lys Ile Val Gln Arg Met Tyr Asn Lys Met Gly Gly Gly 865 870 875 880 Asp Lys Thr Val Ser Phe Ser Glu Glu Val Asp Val Gln Glu Ile Ala 885 890 895 Pro Val Thr Arg Val Lys Leu Glu Phe Glu Phe Asp Asn Glu Ile Val 900 905 910 Thr Gly Val Leu Glu Arg Ala Ile Gly Thr Arg Tyr Lys Phe Thr Gly 915 920 925 Thr Thr Trp Glu Glu Phe Glu Glu Ser Ile Ser Glu Glu Leu Asp Ala 930 935 940 Ile Phe Asp Thr Leu Ala Asn Gln Gly Val Glu Leu Glu Gly Tyr Phe 945 950 955 960 Ile Tyr Asp Thr Cys Gly Gly Phe Asp Ile Lys Asn Pro Asp Gly Ile 965 970 975 Met Ile Ser Gln Tyr Asp Ile Asn Ile Thr Ala Asp Glu Lys Ser Glu 980 985 990 Val Ser Ala Ser Ser Glu Glu Glu Glu Val Glu Ser Val Glu Glu Asp 995 1000 1005 Pro Glu Asn Glu Ile Val Glu Ala Ser Glu Gly Ala Glu Gly Thr 1010 1015 1020 Ser Ser Gln Glu Glu Val Glu Thr Val Glu Val Ala Asp Ile Thr 1025 1030 1035 Ser Thr Glu Glu Asp Val Asp Ile Val Glu Val Ser Ala Lys Asp 1040 1045 1050 Asp Pro Trp Ala Ala Ala Val Asp Val Gln Glu Ala Glu Gln Phe 1055 1060 1065 Asn Pro Ser Leu Pro Pro Phe Lys Thr Thr Asn Leu Asn Gly Lys 1070 1075 1080 Ile Ile Leu Lys Gln Gly Asp Asn Asn Cys Trp Ile Asn Ala Cys 1085 1090 1095 Cys Tyr Gln Leu Gln Ala Phe Asp Phe Phe Asn Asn Glu Ala Trp 1100 1105 1110 Glu Lys Phe Lys Lys Gly Asp Val Met Asp Phe Val Asn Leu Cys 1115 1120 1125 Tyr Ala Ala Thr Thr Leu Ala Arg Gly His Ser Gly Asp Ala Glu 1130 1135 1140 Tyr Leu Leu Glu Leu Met Leu Asn Asp Tyr Ser Thr Ala Lys Ile 1145 1150 1155 Val Leu Ala Ala Lys Cys Gly Cys Gly Glu Lys Glu Ile Val Leu 1160 1165 1170 Glu Arg Ala Val Phe Lys Leu Thr Pro Leu Lys Glu Ser Phe Asn 1175 1180 1185 Tyr Gly Val Cys Gly Asp Cys Met Gln Val Asn Thr Cys Arg Phe 1190 1195 1200 Leu Ser Val Glu Gly Ser Gly Val Phe Val His Asp Ile Leu Ser 1205 1210 1215 Lys Gln Thr Pro Glu Ala Met Phe Val Val Lys Pro Val Met His 1220 1225 1230 Ala Val Tyr Thr Gly Thr Thr Gln Asn Gly His Tyr Met Val Asp 1235 1240 1245 Asp Ile Glu His Gly Tyr Cys Val Asp Gly Met Gly Ile Lys Pro 1250 1255 1260 Leu Lys Lys Arg Cys Tyr Thr Ser Thr Leu Phe Ile Asn Ala Asn 1265 1270 1275 Val Met Thr Arg Ala Glu Lys Pro Lys Gln Glu Phe Lys Val Glu 1280 1285 1290 Lys Val Glu Gln Gln Pro Ile Val Glu Glu Asn Lys Ser Ser Ile 1295 1300 1305 Glu Lys Glu Glu Ile Gln Ser Pro Lys Asn Asp Asp Leu Ile Leu 1310 1315 1320 Pro Phe Tyr Lys Ala Gly Lys Leu Ser Phe Tyr Gln Gly Ala Leu 1325 1330 1335 Asp Val Leu Ile Asn Phe Leu Glu Pro Asp Val Ile Val Asn Ala 1340 1345 1350 Ala Asn Gly Asp Leu Lys His Met Gly Gly Val Ala Arg Ala Ile 1355 1360 1365 Asp Val Phe Thr Gly Gly Lys Leu Thr Glu Arg Ser Lys Asp Tyr 1370 1375 1380 Leu Lys Lys Asn Lys Ser Ile Ala Pro Gly Asn Ala Val Phe Phe 1385 1390 1395 Glu Asn Val Ile Glu His Leu Ser Val Leu Asn Ala Val Gly Pro 1400 1405 1410 Arg Asn Gly Asp Ser Arg Val Glu Ala Lys Leu Cys Asn Val Tyr 1415 1420 1425 Lys Ala Ile Ala Lys Cys Glu Gly Lys Ile Leu Thr Pro Leu Ile 1430 1435 1440 Ser Val Gly Ile Phe Asn Val Arg Leu Glu Thr Ser Leu Gln Cys 1445 1450 1455 Leu Leu Lys Thr Val Asn Asp Arg Gly Leu Asn Val Phe Val Tyr 1460 1465 1470 Thr Asp Gln Glu Arg Gln Thr Ile Glu Asn Phe Phe Ser Cys Ser 1475 1480 1485 Ile Pro Val Asn Val Thr Glu Asp Asn Val Asn His Glu Arg Val 1490 1495 1500 Ser Val Ser Phe Asp Lys Thr Tyr Gly Glu Gln Leu Lys Gly Thr 1505 1510 1515 Val Val Ile Lys Asp Lys Asp Val Thr Asn Gln Leu Pro Ser Ala 1520 1525 1530 Phe Asp Val Gly Gln Lys Val Ile Lys Ala Ile Asp Ile Asp Trp 1535 1540 1545 Gln Ala His Tyr Gly Phe Arg Asp Ala Ala Ala Phe Ser Ala Ser 1550 1555 1560 Ser His Asp Ala Tyr Lys Phe Glu Val Val Thr His Ser Asn Phe 1565 1570 1575 Ile Val His Lys Gln Thr Asp Asn Asn Cys Trp Ile Asn Ala Ile 1580 1585 1590 Cys Leu Ala Leu Gln Arg Leu Lys Pro Gln Trp Lys Phe Pro Gly 1595 1600 1605 Val Arg Gly Leu Trp Asn Glu Phe Leu Glu Arg Lys Thr Gln Gly 1610 1615 1620 Phe Val His Met Leu Tyr His Ile Ser Gly Val Lys Lys Gly Glu 1625 1630 1635 Pro Gly Asp Ala Glu Leu Met Leu His Lys Leu Gly Asp Leu Met 1640 1645 1650 Asp Asn Asp Cys Glu Ile Ile Val Thr His Thr Thr Ala Cys Asp 1655 1660 1665 Lys Cys Ala Lys Val Glu Lys Phe Val Gly Pro Val Val Ala Ala 1670 1675 1680 Pro Leu Ala Ile His Gly Thr Asp Glu Thr Cys Val His Gly Val 1685 1690 1695 Ser Val Asn Val Lys Val Thr Gln Ile Lys Gly Thr Val Ala Ile 1700 1705 1710 Thr Ser Leu Ile Gly Pro Ile Ile Gly Glu Val Leu Glu Ala Thr 1715 1720 1725 Gly Tyr Ile Cys Tyr Ser Gly Ser Asn Arg Asn Gly His Tyr Thr 1730 1735 1740 Tyr Tyr Asp Asn Arg Asn Gly Leu Val Val Asp Ala Glu Lys Ala 1745 1750 1755 Tyr His Phe Asn Arg Asp Leu Leu Gln Val Thr Thr Ala Ile Ala 1760 1765 1770 Ser Asn Phe Val Val Lys Lys Pro Gln Ala Glu Glu Arg Pro Lys 1775 1780 1785 Asn Cys Ala Phe Asn Lys Val Ala Ala Ser Pro Lys Ile Val Gln 1790 1795 1800 Glu Gln Lys Leu Leu Ala Ile Glu Ser Gly Ala Asn Tyr Ala Leu 1805 1810 1815 Thr Glu Phe Gly Arg Tyr Ala Asp Met Phe Phe Met Ala Gly Asp 1820 1825 1830 Lys Ile Leu Arg Leu Leu Leu Glu Val Phe Lys Tyr Leu Leu Val 1835 1840 1845 Leu Phe Met Cys Leu Arg Ser Thr Lys Met Pro Lys Val Lys Val 1850 1855 1860 Lys Pro Pro Leu Ala Phe Lys Asp Phe Gly Ala Lys Val Arg Thr 1865 1870 1875 Leu Asn Tyr Met Arg Gln Leu Asn Lys Pro Ser Val Trp Arg Tyr 1880 1885 1890 Ala Lys Leu Val Leu Leu Leu Ile Ala Ile Tyr Asn Phe Phe Tyr 1895 1900 1905 Leu Phe Val Ser Ile Pro Val Val His Lys Leu Thr Cys Asn Gly 1910 1915 1920 Ala Val Gln Ala Tyr Lys Asn Ser Ser Phe Ile Lys Ser Ala Val 1925 1930 1935 Cys Gly Asn Ser Ile Leu Cys Lys Ala Cys Leu Ala Ser Tyr Asp 1940 1945 1950 Glu Leu Ala Asp Phe Gln His Leu Gln Val Thr Trp Asp Phe Lys 1955 1960 1965 Ser Asp Pro Leu Trp Asn Arg Leu Val Gln Leu Ser Tyr Phe Ala 1970 1975 1980 Phe Leu Ala Val Phe Gly Asn Asn Tyr Val Arg Cys Phe Leu Met 1985 1990 1995 Tyr Phe Val Ser Gln Tyr Leu Asn Leu Trp Leu Ser Tyr Phe Gly 2000 2005 2010 Tyr Val Glu Tyr Ser Trp Phe Leu His Val Val Asn Phe Glu Ser 2015 2020 2025 Ile Ser Ala Glu Phe Val Ile Val Val Ile Val Val Lys Ala Val 2030 2035 2040 Leu Ala Leu Lys His Ile Val Phe Ala Cys Ser Asn Pro Ser Cys 2045 2050 2055 Lys Thr Cys Ser Arg Thr Ala Arg Gln Thr Arg Ile Pro Ile Gln 2060 2065 2070 Val Val Val Asn Gly Ser Met Lys Thr Val Tyr Val His Ala Asn 2075 2080 2085 Gly Thr Gly Lys Phe Cys Lys Lys His Asn Phe Tyr Cys Lys Asn 2090 2095 2100 Cys Asp Ser Tyr Gly Phe Glu Asn Thr Phe Ile Cys Asp Glu Ile 2105 2110 2115 Val Arg Asp Leu Ser Asn Ser Val Lys Gln Thr Val Tyr Ala Thr 2120 2125 2130 Asp Arg Ser His Gln Glu Val Thr Lys Val Glu Cys Ser Asp Gly 2135 2140 2145 Phe Tyr Arg Phe Tyr Val Gly Asp Glu Phe Thr Ser Tyr Asp Tyr 2150 2155 2160 Asp Val Lys His Lys Lys Tyr Ser Ser Gln Glu Val Leu Lys Ser 2165 2170 2175 Met Leu Leu Leu Asp Asp Phe Ile Val Tyr Ser Pro Ser Gly Ser 2180 2185 2190 Ala Leu Ala Asn Val Arg Asn Ala Cys Val Tyr Phe Ser Gln Leu 2195 2200 2205 Ile Gly Lys Pro Ile Lys Ile Val Asn Ser Asp Leu Leu Glu Asp 2210 2215 2220 Leu Ser Val Asp Phe Lys Gly Ala Leu Phe Asn Ala Lys Lys Asn 2225 2230 2235 Val Ile Lys Asn Ser Phe Asn Val Asp Val Ser Glu Cys Lys Asn 2240 2245 2250 Leu Asp Glu Cys Tyr Arg Ala Cys Asn Leu Asn Val Ser Phe Ser 2255 2260 2265 Thr Phe Glu Met Ala Val Asn Asn Ala His Arg Phe Gly Ile Leu 2270 2275 2280 Ile Thr Asp Arg Ser Phe Asn Asn Phe Trp Pro Ser Lys Val Lys 2285 2290 2295 Pro Gly Ser Ser Gly Val Ser Ala Met Asp Ile Gly Lys Cys Met 2300 2305 2310 Thr Ser Asp Ala Lys Ile Val Asn Ala Lys Val Leu Thr Gln Arg 2315 2320 2325 Gly Lys Ser Val Val Trp Leu Ser Gln Asp Phe Ala Ala Leu Ser 2330 2335 2340 Ser Thr Ala Gln Lys Val Leu Val Lys Thr Phe Val Glu Glu Gly 2345 2350 2355 Val Asn Phe Ser Leu Thr Phe Asn Ala Val Gly Ser Asp Asp Asp 2360 2365 2370 Leu Pro Tyr Glu Arg Phe Thr Glu Ser Val Ser Pro Lys Ser Gly 2375 2380 2385 Ser Gly Phe Phe Asp Val Ile Thr Gln Leu Lys Gln Ile Val Ile 2390 2395 2400 Leu Val Phe Val Phe Ile Phe Ile Cys Gly Leu Cys Ser Val Tyr 2405 2410 2415 Ser Val Ala Thr Gln Ser Tyr Ile Glu Ser Ala Glu Gly Tyr Asp 2420 2425 2430 Tyr Met Val Ile Lys Asn Gly Ile Val Gln Pro Phe Asp Asp Thr 2435 2440 2445 Ile Ser Cys Val His Asn Thr Tyr Lys Gly Phe Gly Asp Trp Phe 2450 2455 2460 Lys Ala Lys Tyr Gly Phe Ile Pro Thr Phe Gly Lys Ser Cys Pro 2465 2470 2475 Ile Val Val Gly Thr Val Phe Asp Leu Glu Asn Met Arg Pro Ile 2480 2485 2490 Pro Asp Val Pro Ala Tyr Val Ser Ile Val Gly Arg Ser Leu Val 2495 2500 2505 Phe Ala Ile Asn Ala Ala Phe Gly Val Thr Asn Met Cys Tyr Asp 2510 2515 2520 His Thr Gly Asn Ala Val Ser Lys Asp Ser Tyr Phe Asp Thr Cys 2525 2530 2535 Val Phe Asn Thr Ala Cys Thr Thr Leu Thr Gly Leu Gly Gly Thr 2540 2545 2550 Ile Val Tyr Cys Ala Lys Gln Gly Leu Val Glu Gly Ala Lys Leu 2555 2560 2565 Tyr Ser Asp Leu Met Pro Asp Tyr Tyr Tyr Glu His Ala Ser Gly 2570 2575 2580 Asn Met Val Lys Leu Pro Ala Ile Ile Arg Gly Leu Gly Leu Arg 2585 2590 2595 Phe Val Lys Thr Gln Ala Thr Thr Tyr Cys Arg Val Gly Glu Cys 2600 2605 2610 Ile Asp Ser Lys Ala Gly Phe Cys Phe Gly Gly Asp Asn Trp Phe 2615 2620 2625 Val Tyr Asp Asn Glu Phe Gly Asn Gly Tyr Ile Cys Gly Asn Ser 2630 2635 2640 Val Leu Gly Phe Phe Lys Asn Val Phe Lys Leu Phe Asn Ser Asn 2645 2650 2655 Met Ser Val Val Ala Thr Ser Gly Ala Met Leu Val Asn Ile Ile 2660 2665 2670 Ile Ala Cys Leu Ala Ile Ala Met Cys Tyr Gly Val Leu Lys Phe 2675 2680 2685 Lys Lys Ile Phe Gly Asp Cys Thr Phe Leu Ile Val Met Ile Ile 2690 2695 2700 Val Thr Leu Val Val Asn Asn Val Ser Tyr Phe Val Thr Gln Asn 2705 2710 2715 Thr Phe Phe Met Ile Ile Tyr Ala Ile Val Tyr Tyr Phe Ile Thr 2720 2725 2730 Arg Lys Leu Ala Tyr Pro Gly Ile Leu Asp Ala Gly Phe Ile Ile 2735 2740 2745 Ala Tyr Ile Asn Met Ala Pro Trp Tyr Val Ile Thr Ala Tyr Ile 2750 2755 2760 Leu Val Phe Leu Tyr Asp Ser Leu Pro Ser Leu Phe Lys Leu Lys 2765 2770 2775 Val Ser Thr Asn Leu Phe Glu Gly Asp Lys Phe Val Gly Asn Phe 2780 2785 2790 Glu Ser Ala Ala Met Gly Thr Phe Val Ile Asp Met Arg Ser Tyr 2795 2800 2805 Glu Thr Ile Val Asn Ser Thr Ser Ile Ala Arg Ile Lys Ser Tyr 2810 2815 2820 Ala Asn Ser Phe Asn Lys Tyr Lys Tyr Tyr Thr Gly Ser Met Gly 2825 2830 2835 Glu Ala Asp Tyr Arg Met Ala Cys Tyr Ala His Leu Gly Lys Ala 2840 2845 2850 Leu Met Asp Tyr Ser Val Asn Arg Thr Asp Met Leu Tyr Thr Pro 2855 2860 2865 Pro Thr Val Ser Val Asn Ser Thr Leu Gln Ser Gly Leu Arg Lys 2870 2875 2880 Met Ala Gln Pro Ser Gly Leu Val Glu Pro Cys Ile Val Arg Val 2885 2890 2895 Ser Tyr Gly Asn Asn Val Leu Asn Gly Leu Trp Leu Gly Asp Glu 2900 2905 2910 Val Ile Cys Pro Arg His Val Ile Ala Ser Asp Thr Thr Arg Val 2915 2920 2925 Ile Asn Tyr Glu Asn Glu Met Ser Ser Val Arg Leu His Asn Phe 2930 2935 2940 Ser Val Ser Lys Asn Asn Val Phe Leu Gly Val Val Ser Ala Arg 2945 2950 2955 Tyr Lys Gly Val Asn Leu Val Leu Lys Val Asn Gln Val Asn Pro 2960 2965 2970 Asn Thr Pro Glu His Lys Phe Lys Ser Ile Lys Ala Gly Glu Ser 2975 2980 2985 Phe Asn Ile Leu Ala Cys Tyr Glu Gly Cys Pro Gly Ser Val Tyr 2990 2995 3000 Gly Val Asn Met Arg Ser Gln Gly Thr Ile Lys Gly Ser Phe Ile 3005 3010 3015 Ala Gly Thr Cys Gly Ser Val Gly Tyr Val Leu Glu Asn Gly Ile 3020 3025 3030 Leu Tyr Phe Val Tyr Met His His Leu Glu Leu Gly Asn Gly Ser 3035 3040 3045 His Val Gly Ser Asn Phe Glu Gly Glu Met Tyr Gly Gly Tyr Glu 3050 3055 3060 Asp Gln Pro Ser Met Gln Leu Glu Gly Thr Asn Val Met Ser Ser 3065 3070 3075 Asp Asn Val Val Ala Phe Leu Tyr Ala Ala Leu Ile Asn Gly Glu 3080 3085 3090 Arg Trp Phe Val Thr Asn Thr Ser Met Ser Leu Glu Ser Tyr Asn 3095 3100 3105 Thr Trp Ala Lys Thr Asn Ser Phe Thr Glu Leu Ser Ser Thr Asp 3110 3115 3120 Ala Phe Ser Met Leu Ala Ala Lys Thr Gly Gln Ser Val Glu Lys 3125 3130 3135 Leu Leu Asp Ser Ile Val Arg Leu Asn Lys Gly Phe Gly Gly Arg 3140 3145 3150 Thr Ile Leu Ser Tyr Gly Ser Leu Cys Asp Glu Phe Thr Pro Thr 3155 3160 3165 Glu Val Ile Arg Gln Met Tyr Gly Val Asn Leu Gln Ala Gly Lys 3170 3175 3180 Val Lys Ser Phe Phe Tyr Pro Ile Met Thr Ala Met Thr Ile Leu 3185 3190 3195 Phe Ala Phe Trp Leu Glu Phe Phe Met Tyr Thr Pro Phe Thr Trp 3200 3205 3210 Ile Asn Pro Thr Phe Val Ser Ile Val Leu Ala Val Thr Thr Leu 3215 3220 3225 Ile Ser Thr Val Phe Val Ser Gly Ile Lys His Lys Met Leu Phe 3230 3235 3240 Phe Met Ser Phe Val Leu Pro Ser Val Ile Leu Val Thr Ala His 3245 3250 3255 Asn Leu Phe Trp Asp Phe Ser Tyr Tyr Glu Ser Leu Gln Ser Ile 3260 3265 3270 Val Glu Asn Thr Asn Thr Met Phe Leu Pro Val Asp Met Gln Gly 3275 3280 3285 Val Met Leu Thr Val Phe Cys Phe Ile Val Phe Val Thr Tyr Ser 3290 3295 3300 Val Arg Phe Phe Thr Cys Lys Gln Ser Trp Phe Ser Leu Ala Val 3305 3310 3315 Thr Thr Ile Leu Val Ile Phe Asn Met Val Lys Ile Phe Gly Thr 3320 3325 3330 Ser Asp Glu Pro Trp Thr Glu Asn Gln Ile Ala Phe Cys Phe Val 3335 3340 3345 Asn Met Leu Thr Met Ile Val Ser Leu Thr Thr Lys Asp Trp Met 3350 3355 3360 Val Val Ile Ala Ser Tyr Arg Ile Ala Tyr Tyr Ile Val Val Cys 3365 3370 3375 Val Met Pro Ser Ala Phe Val Ser Asp Phe Gly Phe Met Lys Cys 3380 3385 3390 Ile Ser Ile Val Tyr Met Ala Cys Gly Tyr Leu Phe Cys Cys Tyr 3395 3400 3405 Tyr Gly Ile Leu Tyr Trp Val Asn Arg Phe Thr Cys Met Thr Cys 3410 3415 3420 Gly Val Tyr Gln Phe Thr Val Ser Ala Ala Glu Leu Lys Tyr Met 3425 3430 3435 Thr Ala Asn Asn Leu Ser Ala Pro Lys Asn Ala Tyr Asp Ala Met 3440 3445 3450 Ile Leu Ser Ala Lys Leu Ile Gly Val Gly Gly Lys Arg Asn Ile 3455 3460 3465 Lys Ile Ser Thr Val Gln Ser Lys Leu Thr Glu Met Lys Cys Thr 3470 3475 3480 Asn Val Val Leu Leu Gly Leu Leu Ser Lys Met His Val Glu Ser 3485 3490 3495 Asn Ser Lys Glu Trp Asn Tyr Cys Val Gly Leu His Asn Glu Ile 3500 3505 3510 Asn Leu Cys Asp Asp Pro Glu Ile Val Leu Glu Lys Leu Leu Ala 3515 3520 3525 Leu Ile Ala Phe Phe Leu Ser Lys His Asn Thr Cys Asp Leu Ser 3530 3535 3540 Glu Leu Ile Glu Ser Tyr Phe Glu Asn Thr Thr Ile Leu Gln Ser 3545 3550 3555 Val Ala Ser Ala Tyr Ala Ala Leu Pro Ser Trp Ile Ala Leu Glu 3560 3565 3570 Lys Ala Arg Ala Asp Leu Glu Glu Ala Lys Lys Asn Asp Val Ser 3575 3580 3585 Pro Gln Ile Leu Lys Gln Leu Thr Lys Ala Phe Asn Ile Ala Lys 3590 3595 3600 Ser Asp Phe Glu Arg Glu Ala Ser Val Gln Lys Lys Leu Asp Lys 3605 3610 3615 Met Ala Glu Gln Ala Ala Ala Ser Met Tyr Lys Glu Ala Arg Ala 3620 3625 3630 Val Asp Arg Lys Ser Lys Ile Val Ser Ala Met His Ser Leu Leu 3635 3640 3645 Phe Gly Met Leu Lys Lys Leu Asp Met Ser Ser Val Asn Thr Ile 3650 3655 3660 Ile Asp Gln Ala Arg Asn Gly Val Leu Pro Leu Ser Ile Ile Pro 3665 3670 3675 Ala Ala Ser Ala Thr Arg Leu Val Val Ile Thr Pro Ser Leu Glu 3680 3685 3690 Val Phe Ser Lys Ile Arg Gln Glu Asn Asn Val His Tyr Ala Gly 3695 3700 3705 Ala Ile Trp Thr Ile Val Glu Val Lys Asp Ala Asn Gly Ser His 3710 3715 3720 Val His Leu Lys Glu Val Thr Ala Ala Asn Glu Leu Asn Leu Thr 3725 3730 3735 Trp Pro Leu Ser Ile Thr Cys Glu Arg Thr Thr Lys Leu Gln Asn 3740 3745 3750 Asn Glu Ile Met Pro Gly Lys Leu Lys Glu Arg Ala Val Arg Ala 3755 3760 3765 Ser Ala Thr Leu Asp Gly Glu Ala Phe Gly Ser Gly Lys Ala Leu 3770 3775 3780 Met Ala Ser Glu Ser Gly Lys Ser Phe Met Tyr Ala Phe Ile Ala 3785 3790 3795 Ser Asp Asn Asn Leu Lys Tyr Val Lys Trp Glu Ser Asn Asn Asp 3800 3805 3810 Ile Ile Pro Ile Glu Leu Glu Ala Pro Leu Arg Phe Tyr Val Asp 3815 3820 3825 Gly Ala Asn Gly Pro Glu Val Lys Tyr Leu Tyr Phe Val Lys Asn 3830 3835 3840 Leu Asn Thr Leu Arg Arg Gly Ala Val Leu Gly Tyr Ile Gly Ala 3845 3850 3855 Thr Val Arg Leu Gln Ala Gly Lys Pro Thr Glu His Pro Ser Asn 3860 3865 3870 Ser Ser Leu Leu Thr Leu Cys Ala Phe Ser Pro Asp Pro Ala Lys 3875 3880 3885 Ala Tyr Val Asp Ala Val Lys Arg Gly Met Gln Pro Val Asn Asn 3890 3895 3900 Cys Val Lys Met Leu Ser Asn Gly Ala Gly Asn Gly Met Ala Val 3905 3910 3915 Thr Asn Gly Val Glu Ala Asn Thr Gln Gln Asp Ser Tyr Gly Gly 3920 3925 3930 Ala Ser Val Cys Ile Tyr Cys Arg Cys His Val Glu His Pro Ala 3935 3940 3945 Ile Asp Gly Leu Cys Arg Tyr Lys Gly Lys Phe Val Gln Ile Pro 3950 3955 3960 Thr Gly Thr Gln Asp Pro Ile Arg Phe Cys Ile Glu Asn Glu Val 3965 3970 3975 Cys Val Val Cys Gly Cys Trp Leu Asn Asn Gly Cys Met Cys Asp 3980 3985 3990 Arg Thr Ser Met Gln Ser Phe Thr Val Asp Gln Ser Tyr Leu Asn 3995 4000 4005 Glu Cys Gly Val Leu Val Gln Leu Asp 4010 4015 <210> 14 <211> 4055 <212> PRT <213> EMCR Coronavirus <220> <221> MISC_FEATURE <223> ORF 1A <400> 14 Met Phe Tyr Asn Gln Val Thr Leu Ala Val Ala Ser Asp Ser Glu Ile 1 5 10 15 Ser Gly Phe Gly Phe Ala Ile Pro Ser Val Ala Val Arg Ala Tyr Ser 20 25 30 Glu Ala Ala Ala Gln Gly Phe Gln Ala Cys Arg Phe Val Ala Phe Gly 35 40 45 Leu Gln Asp Cys Val Thr Gly Ile Asn Asp Asp Asp Tyr Val Ile Ala 50 55 60 Leu Thr Gly Thr Asn Gln Leu Cys Ala Lys Ile Leu Leu Phe Ser Asp 65 70 75 80 Arg Pro Leu Asn Leu Arg Gly Trp Leu Ile Phe Ser Asn Ser Asn Tyr 85 90 95 Val Leu Gln Asp Phe Asp Val Val Phe Gly His Gly Ala Gly Ser Val 100 105 110 Val Phe Val Asp Lys Tyr Met Cys Gly Phe Asp Gly Lys Pro Val Leu 115 120 125 Pro Lys Asn Met Trp Glu Phe Arg Asp Tyr Phe Asn Asp Asn Thr Asp 130 135 140 Ser Ile Val Ile Gly Gly Val Thr Tyr Gln Leu Ala Trp Asp Val Ile 145 150 155 160 Arg Lys Asp Leu Ser Tyr Glu Gln Gln Asn Val Leu Ala Ile Glu Ser 165 170 175 Ile His Tyr Leu Gly Thr Thr Gly His Thr Leu Lys Ser Gly Cys Lys 180 185 190 Leu Ile Asn Ala Lys Pro Pro Lys Tyr Ser Ser Lys Val Val Leu Ser 195 200 205 Gly Glu Trp Asn Ala Val Tyr Lys Ala Phe Gly Ser Pro Phe Ile Thr 210 215 220 Asn Gly Ile Ser Leu Leu Asp Ile Ile Val Lys Pro Val Phe Phe Asn 225 230 235 240 Ala Phe Val Lys Cys Asn Cys Gly Ser Glu Asn Trp Ser Val Gly Ala 245 250 255 Trp Asp Gly Tyr Leu Ser Ser Cys Cys Gly Thr Pro Ala Lys Lys Leu 260 265 270 Cys Val Val Pro Gly Asn Val Val Pro Gly Asp Val Ile Ile Thr Ser 275 280 285 Thr Asp Ala Gly Cys Gly Val Lys Tyr Tyr Ala Gly Leu Val Val Lys 290 295 300 His Ile Thr Asn Ile Thr Gly Val Ser Leu Trp Arg Val Thr Ala Val 305 310 315 320 His Ser Asp Gly Met Phe Val Ala Thr Ser Ser Tyr Asp Ala Leu Leu 325 330 335 His Arg Asn Ser Leu Asp Pro Phe Cys Phe Asp Val Asn Thr Leu Leu 340 345 350 Ser Asn Gln Leu Arg Leu Ala Phe Leu Gly Ala Ser Val Thr Glu Asp 355 360 365 Val Lys Phe Ala Ala Ser Thr Gly Val Ile Asp Ile Ser Ala Gly Met 370 375 380 Phe Gly Leu Tyr Asp Asp Ile Leu Thr Asn Asn Lys Pro Trp Phe Val 385 390 395 400 Arg Lys Ala Ser Gly Leu Phe Asp Ala Ile Trp Asp Ala Phe Val Ala 405 410 415 Ala Ile Lys Leu Val Pro Thr Thr Thr Gly Gly Leu Val Arg Phe Val 420 425 430 Lys Ser Ile Ala Ser Thr Val Leu Thr Val Ser Asn Gly Val Ile Ile 435 440 445 Met Cys Ala Asp Val Pro Asp Ala Phe Gln Pro Val Tyr Arg Thr Phe 450 455 460 Thr Gln Ala Ile Cys Ala Ala Phe Asp Phe Ser Leu Asp Val Phe Lys 465 470 475 480 Ile Gly Asp Val Lys Phe Lys Arg Leu Gly Asp Tyr Val Leu Thr Glu 485 490 495 Asn Ala Leu Val Arg Leu Thr Thr Glu Val Val Arg Gly Val Arg Asp 500 505 510 Ala Arg Ile Lys Lys Ala Met Phe Thr Lys Val Val Val Gly Pro Thr 515 520 525 Thr Glu Val Lys Phe Ser Val Ile Glu Leu Ala Thr Val Asn Leu Arg 530 535 540 Leu Val Asp Cys Ala Pro Val Val Cys Pro Lys Gly Lys Ile Val Val 545 550 555 560 Ile Ala Gly Gln Ala Phe Phe Tyr Ser Gly Gly Phe Tyr Arg Phe Met 565 570 575 Val Asp Ser Thr Thr Val Leu Asn Asp Pro Val Phe Thr Gly Glu Leu 580 585 590 Phe Tyr Thr Ile Lys Phe Ser Gly Phe Lys Leu Asp Gly Phe Asn His 595 600 605 Gln Phe Val Asn Ala Ser Ser Ala Thr Asp Ala Ile Ile Ala Val Glu 610 615 620 Leu Leu Leu Ser Asp Phe Lys Thr Ala Val Phe Val Tyr Thr Cys Val 625 630 635 640 Val Asp Gly Cys Ser Val Ile Val Arg Arg Asp Ala Thr Phe Ala Thr 645 650 655 His Val Cys Phe Lys Asp Cys Tyr Ser Ile Trp Glu Gln Phe Cys Ile 660 665 670 Asp Asn Cys Gly Glu Pro Trp Phe Leu Thr Asp Tyr Asn Ala Ile Leu 675 680 685 Gln Ser Asn Asn Pro Gln Cys Ala Ile Val Gln Ala Ser Glu Ser Lys 690 695 700 Val Leu Leu Glu Arg Phe Leu Pro Lys Cys Pro Glu Ile Leu Leu Ser 705 710 715 720 Ile Asp Asp Gly His Leu Trp Asn Leu Phe Val Glu Lys Phe Asn Phe 725 730 735 Val Thr Asp Trp Leu Lys Thr Leu Lys Leu Thr Leu Thr Ser Asn Gly 740 745 750 Leu Leu Gly Asn Cys Ala Lys Arg Phe Arg Arg Val Leu Val Lys Leu 755 760 765 Leu Asp Val Tyr Asn Gly Phe Leu Glu Thr Val Cys Ser Val Val His 770 775 780 Thr Ala Gly Val Cys Ile Lys Tyr Tyr Ala Val Asn Val Pro Tyr Val 785 790 795 800 Val Ile Ser Gly Phe Val Ser Arg Val Ile Arg Arg Glu Arg Cys Asp 805 810 815 Val Thr Phe Pro Cys Val Ser Cys Val Thr Phe Phe Tyr Glu Phe Leu 820 825 830 Asp Thr Cys Phe Gly Val Ser Lys Pro Asn Ala Ile Asp Val Glu His 835 840 845 Leu Glu Leu Lys Glu Thr Val Phe Val Glu Pro Lys Asp Gly Gly Gln 850 855 860 Phe Phe Val Ser Asp Asp Tyr Leu Trp Tyr Val Val Asp Asp Ile Tyr 865 870 875 880 Tyr Pro Ala Ser Cys Asn Gly Val Leu Pro Val Ala Phe Thr Lys Leu 885 890 895 Ala Gly Gly Lys Ile Ser Phe Ser Asp Asp Val Ile Val His Asp Val 900 905 910 Glu Pro Thr His Lys Val Lys Leu Ile Phe Glu Phe Glu Asp Asp Val 915 920 925 Val Thr Ser Leu Cys Lys Lys Ser Phe Gly Lys Ser Ile Ile Tyr Thr 930 935 940 Gly Asp Trp Glu Gly Leu His Glu Val Leu Thr Ser Ala Met Asn Val 945 950 955 960 Ile Gly Gln His Ile Lys Leu Pro Gln Phe Tyr Ile Tyr Asp Glu Glu 965 970 975 Gly Gly Tyr Asp Val Ser Lys Pro Val Met Ile Ser Gln Trp Pro Ile 980 985 990 Ser Asp Asp Ser Asp Gly Cys Val Val Glu Ala Ser Thr Asp Phe His 995 1000 1005 Gln Leu Glu Ser Val Arg Glu Glu Val Asp Ile Ile Glu Gln Pro 1010 1015 1020 Phe Gly Glu Val Glu His Ala Leu Ser Ile Arg Gln Pro Phe Ser 1025 1030 1035 Phe Ser Phe Arg Asp Glu Leu Gly Val Arg Val Leu Asp Gln Ser 1040 1045 1050 Asp Asn Asn Cys Trp Ile Ser Thr Thr Leu Ile Gln Leu Gln Leu 1055 1060 1065 Thr Lys Leu Leu Asp Asp Ser Ile Glu Met Gln Leu Phe Lys Val 1070 1075 1080 Gly Lys Val Asp Ser Ile Val Gln Lys Cys Tyr Glu Leu Ser His 1085 1090 1095 Leu Ile Ser Gly Ser Leu Gly Asp Ser Gly Lys Leu Leu Ser Glu 1100 1105 1110 Leu Leu Lys Asp Lys Tyr Thr Cys Ser Ile Thr Phe Glu Met Ser 1115 1120 1125 Cys Asp Cys Gly Lys Lys Phe Asp Glu Gln Val Gly Cys Leu Phe 1130 1135 1140 Trp Ile Met Pro Tyr Thr Lys Leu Phe Gln Lys Gly Glu Cys Cys 1145 1150 1155 Ile Cys His Lys Met Gln Thr Tyr Lys Leu Val Ser Met Lys Gly 1160 1165 1170 Thr Gly Val Phe Val Gln Asp Pro Ala Pro Ile Asp Ile Asp Ala 1175 1180 1185 Phe Pro Val Arg Pro Ile Cys Ser Ser Val Tyr Leu Gly Val Lys 1190 1195 1200 Gly Ser Gly His Tyr Gln Thr Asn Leu Tyr Ser Phe Asp Lys Ala 1205 1210 1215 Ile Asp Gly Phe Gly Val Phe Asp Ile Lys Asn Ser Ser Val Asn 1220 1225 1230 Thr Val Cys Phe Val Asp Val Asp Phe His Ser Val Glu Ile Glu 1235 1240 1245 Ala Gly Glu Val Lys Pro Phe Ala Val Tyr Lys Asn Val Lys Phe 1250 1255 1260 Tyr Leu Gly Asp Ile Ser His Leu Val Asn Cys Val Ser Phe Asp 1265 1270 1275 Phe Val Val Asn Ala Ala Asn Glu Asn Leu Met His Gly Gly Gly 1280 1285 1290 Val Ala Arg Ala Ile Asp Ile Leu Thr Glu Gly Gln Leu Gln Ser 1295 1300 1305 Leu Ser Lys Asp Tyr Ile Ser Ser Asn Gly Pro Leu Lys Val Gly 1310 1315 1320 Ala Gly Val Met Leu Glu Cys Glu Lys Phe Asn Val Phe Asn Val 1325 1330 1335 Val Gly Pro Arg Thr Gly Lys His Glu His Ser Leu Leu Val Glu 1340 1345 1350 Ala Tyr Asn Ser Ile Leu Phe Glu Asn Gly Ile Pro Leu Met Pro 1355 1360 1365 Leu Leu Ser Cys Gly Ile Phe Gly Val Arg Ile Glu Asn Ser Leu 1370 1375 1380 Lys Ala Leu Phe Ser Cys Asp Ile Asn Lys Pro Leu Gln Val Phe 1385 1390 1395 Val Tyr Ser Ser Asn Glu Glu Gln Ala Val Leu Lys Phe Leu Asp 1400 1405 1410 Gly Leu Asp Leu Thr Pro Val Ile Asp Asp Val Asp Val Val Lys 1415 1420 1425 Pro Phe Arg Val Glu Gly Asn Phe Ser Phe Phe Asp Cys Gly Val 1430 1435 1440 Asn Ala Leu Asp Gly Asp Ile Tyr Leu Leu Phe Thr Asn Ser Ile 1445 1450 1455 Leu Met Leu Asp Lys Gln Gly Gln Leu Leu Asp Thr Lys Leu Asn 1460 1465 1470 Gly Ile Leu Gln Gln Ala Val Leu Asp Tyr Leu Ala Thr Val Lys 1475 1480 1485 Thr Val Pro Ala Gly Asn Leu Val Lys Leu Val Val Glu Ser Cys 1490 1495 1500 Thr Ile Tyr Met Cys Val Val Pro Ser Ile Asn Asp Leu Ser Phe 1505 1510 1515 Asp Lys Asn Leu Gly Arg Cys Val Arg Lys Leu Asn Arg Leu Lys 1520 1525 1530 Thr Cys Val Ile Ala Asn Val Pro Ala Ile Asp Val Leu Lys Lys 1535 1540 1545 Leu Leu Ser Ser Leu Thr Leu Thr Val Lys Phe Val Val Glu Ser 1550 1555 1560 Asn Val Met Asp Val Asn Asp Cys Phe Lys Asn Asp Asn Val Val 1565 1570 1575 Leu Lys Ile Thr Glu Asp Gly Ile Asn Val Lys Asp Val Val Val 1580 1585 1590 Glu Ser Ser Lys Ser Leu Gly Lys Gln Leu Gly Val Val Ser Asp 1595 1600 1605 Gly Val Asp Ser Phe Glu Gly Val Leu Pro Ile Asn Thr Asp Thr 1610 1615 1620 Val Leu Ser Val Ala Pro Glu Val Asp Trp Val Ala Phe Tyr Gly 1625 1630 1635 Phe Glu Lys Ala Ala Leu Phe Ala Ser Leu Asp Val Lys Pro Tyr 1640 1645 1650 Gly Tyr Pro Asn Asp Phe Val Gly Gly Phe Arg Val Leu Gly Thr 1655 1660 1665 Thr Asp Asn Asn Cys Trp Val Asn Ala Thr Cys Ile Ile Leu Gln 1670 1675 1680 Tyr Leu Lys Pro Thr Phe Lys Ser Lys Gly Leu Asn Val Leu Trp 1685 1690 1695 Asn Lys Phe Val Thr Gly Asp Val Gly Pro Phe Val Ser Phe Ile 1700 1705 1710 Tyr Phe Ile Thr Met Ser Ser Lys Gly Gln Lys Gly Asp Ala Glu 1715 1720 1725 Glu Ala Leu Ser Lys Leu Ser Glu Tyr Leu Ile Ser Asp Ser Ile 1730 1735 1740 Val Thr Leu Glu Gln Tyr Ser Thr Cys Asp Ile Cys Lys Ser Thr 1745 1750 1755 Val Val Glu Val Lys Ser Ala Val Val Cys Ala Ser Val Leu Lys 1760 1765 1770 Asp Gly Cys Asp Val Gly Phe Cys Pro His Arg His Lys Leu Arg 1775 1780 1785 Ser Arg Val Lys Phe Val Asn Gly Arg Val Val Ile Thr Asn Val 1790 1795 1800 Gly Glu Pro Ile Ile Ser Gln Pro Ser Lys Leu Leu Asn Gly Ile 1805 1810 1815 Ala Tyr Thr Thr Phe Ser Gly Ser Phe Asp Asn Gly His Tyr Val 1820 1825 1830 Val Tyr Asp Ala Ala Asn Asn Ala Val Tyr Asp Gly Ala Arg Leu 1835 1840 1845 Phe Ala Ser Asp Leu Ser Thr Leu Ala Val Thr Ala Ile Val Val 1850 1855 1860 Val Gly Gly Cys Val Thr Ser Asn Val Pro Pro Ile Val Ser Glu 1865 1870 1875 Lys Ile Ser Val Met Asp Lys Leu Asp Thr Gly Ala Gln Lys Phe 1880 1885 1890 Phe Gln Phe Gly Asp Phe Val Met Asn Asn Ile Val Leu Phe Leu 1895 1900 1905 Thr Trp Leu Leu Ser Met Phe Ser Leu Leu Arg Thr Ser Ile Met 1910 1915 1920 Lys His Asp Ile Lys Val Ile Ala Lys Ala Pro Lys Arg Thr Gly 1925 1930 1935 Val Ile Leu Thr Arg Ser Phe Lys Tyr Asn Ile Arg Ser Ala Leu 1940 1945 1950 Phe Val Val Lys Gln Lys Trp Cys Val Ile Val Thr Leu Phe Lys 1955 1960 1965 Phe Leu Leu Leu Leu Tyr Ala Ile Tyr Ala Leu Val Phe Met Ile 1970 1975 1980 Val Gln Phe Ser Pro Phe Asn Ser Leu Leu Cys Gly Asp Ile Val 1985 1990 1995 Ser Gly Tyr Glu Lys Ser Thr Phe Asn Lys Asp Ile Tyr Cys Gly 2000 2005 2010 Asn Ser Met Val Cys Lys Met Cys Leu Phe Ser Tyr Gln Glu Phe 2015 2020 2025 Asn Asp Leu Asp His Thr Ser Leu Val Trp Lys His Ile Arg Asp 2030 2035 2040 Pro Ile Leu Ile Ser Leu Gln Pro Phe Val Ile Leu Val Ile Leu 2045 2050 2055 Leu Ile Phe Gly Asn Met Tyr Leu Arg Phe Gly Leu Leu Tyr Phe 2060 2065 2070 Val Ala Gln Phe Ile Ser Thr Phe Gly Ser Phe Leu Gly Phe His 2075 2080 2085 Gln Lys Gln Trp Phe Leu His Phe Val Pro Phe Asp Val Leu Cys 2090 2095 2100 Asn Glu Phe Leu Ala Thr Phe Ile Val Cys Lys Ile Val Leu Phe 2105 2110 2115 Val Arg His Ile Ile Val Gly Cys Asn Asn Ala Asp Cys Val Ala 2120 2125 2130 Cys Ser Lys Ser Ala Arg Leu Lys Arg Val Pro Leu Gln Thr Ile 2135 2140 2145 Ile Asn Gly Met His Lys Ser Phe Tyr Val Asn Ala Asn Gly Gly 2150 2155 2160 Thr Cys Phe Cys Asn Lys His Asn Phe Phe Cys Val Asn Cys Asp 2165 2170 2175 Ser Phe Gly Pro Gly Asn Thr Phe Ile Asn Gly Asp Ile Ala Arg 2180 2185 2190 Glu Leu Gly Asn Val Val Lys Thr Ala Val Gln Pro Thr Ala Pro 2195 2200 2205 Ala Tyr Val Ile Ile Asp Lys Val Asp Phe Val Asn Gly Phe Tyr 2210 2215 2220 Arg Leu Tyr Ser Gly Asp Thr Phe Trp Arg Tyr Asp Phe Asp Ile 2225 2230 2235 Thr Glu Ser Lys Tyr Ser Cys Lys Glu Val Leu Lys Asn Cys Asn 2240 2245 2250 Val Leu Glu Asn Phe Ile Val Tyr Asn Asn Ser Gly Ser Asn Ile 2255 2260 2265 Thr Gln Ile Lys Asn Ala Cys Val Tyr Phe Ser Gln Leu Leu Cys 2270 2275 2280 Glu Pro Ile Lys Leu Val Asn Ser Glu Leu Leu Ser Thr Leu Ser 2285 2290 2295 Val Asp Phe Asn Gly Val Leu His Lys Ala Tyr Val Asp Val Leu 2300 2305 2310 Cys Asn Ser Phe Phe Lys Glu Leu Thr Ala Asn Met Ser Met Ala 2315 2320 2325 Glu Cys Lys Ala Thr Leu Gly Leu Thr Val Ser Asp Asp Asp Phe 2330 2335 2340 Val Ser Ala Val Ala Asn Ala His Arg Tyr Asp Val Leu Leu Ser 2345 2350 2355 Asp Leu Ser Phe Asn Asn Phe Phe Ile Ser Tyr Ala Lys Pro Glu 2360 2365 2370 Asp Lys Leu Ser Val Tyr Asp Ile Ala Cys Cys Met Arg Ala Gly 2375 2380 2385 Ser Lys Val Val Asn His Asn Val Leu Ile Lys Glu Ser Ile Pro 2390 2395 2400 Ile Val Trp Gly Val Lys Asp Phe Asn Thr Leu Ser Gln Glu Gly 2405 2410 2415 Lys Lys Tyr Leu Val Lys Thr Thr Lys Ala Lys Gly Leu Thr Phe 2420 2425 2430 Leu Leu Thr Phe Asn Asp Asn Gln Ala Ile Thr Gln Val Pro Ala 2435 2440 2445 Thr Ser Ile Val Ala Lys Gln Gly Ala Gly Phe Lys Arg Thr Tyr 2450 2455 2460 Asn Phe Leu Trp Tyr Val Cys Leu Phe Val Val Ala Leu Phe Ile 2465 2470 2475 Gly Val Ser Phe Ile Asp Tyr Thr Thr Thr Val Thr Ser Phe His 2480 2485 2490 Gly Tyr Asp Phe Lys Tyr Ile Glu Asn Gly Gln Leu Lys Val Phe 2495 2500 2505 Glu Ala Pro Leu His Cys Val Arg Asn Val Phe Asp Asn Phe Asn 2510 2515 2520 Gln Trp His Glu Ala Lys Phe Gly Val Val Thr Thr Asn Ser Asp 2525 2530 2535 Lys Cys Pro Ile Val Val Gly Val Ser Glu Arg Ile Asn Val Val 2540 2545 2550 Pro Gly Val Pro Thr Asn Val Tyr Leu Val Gly Lys Thr Leu Val 2555 2560 2565 Phe Thr Leu Gln Ala Ala Phe Gly Asn Thr Gly Val Cys Tyr Asp 2570 2575 2580 Phe Asp Gly Val Thr Thr Ser Asp Lys Cys Ile Phe Asn Ser Ala 2585 2590 2595 Cys Thr Arg Leu Glu Gly Leu Gly Gly Asp Asn Val Tyr Cys Tyr 2600 2605 2610 Asn Thr Asp Leu Ile Glu Gly Ser Lys Pro Tyr Ser Ile Leu Gln 2615 2620 2625 Pro Asn Ala Tyr Tyr Lys Tyr Asp Val Lys Asn Tyr Val Arg Phe 2630 2635 2640 Pro Glu Ile Leu Ala Arg Gly Phe Gly Leu Arg Thr Ile Arg Thr 2645 2650 2655 Leu Ala Thr Arg Tyr Cys Arg Val Gly Glu Cys Arg Asp Ser His 2660 2665 2670 Lys Gly Val Cys Phe Gly Phe Asp Lys Trp Tyr Val Asn Asp Gly 2675 2680 2685 Arg Val Asp Asp Gly Tyr Ile Cys Gly Asp Gly Leu Ile Asp Leu 2690 2695 2700 Leu Val Asn Val Leu Ser Ile Phe Ser Ser Ser Phe Ser Val Val 2705 2710 2715 Ala Met Ser Gly His Met Leu Phe Asn Phe Leu Phe Ala Ala Phe 2720 2725 2730 Ile Thr Phe Leu Cys Phe Leu Val Thr Lys Phe Lys Arg Val Phe 2735 2740 2745 Gly Asp Leu Ser Tyr Gly Val Phe Thr Val Val Cys Ala Thr Leu 2750 2755 2760 Ile Asn Asn Ile Ser Tyr Val Val Thr Gln Asn Leu Phe Phe Met 2765 2770 2775 Leu Leu Tyr Ala Ile Leu Tyr Phe Val Phe Thr Arg Thr Val Arg 2780 2785 2790 Tyr Ala Trp Ile Trp His Ile Ala Tyr Ile Val Ala Tyr Phe Leu 2795 2800 2805 Leu Ile Pro Trp Trp Leu Leu Thr Trp Phe Ser Phe Ala Ala Phe 2810 2815 2820 Leu Glu Leu Leu Pro Asn Val Phe Lys Leu Lys Ile Ser Thr Gln 2825 2830 2835 Leu Phe Glu Gly Asp Lys Phe Ile Gly Thr Phe Glu Ser Ala Ala 2840 2845 2850 Ala Gly Thr Phe Val Leu Asp Met Arg Ser Tyr Glu Arg Leu Ile 2855 2860 2865 Asn Thr Ile Ser Pro Glu Lys Leu Lys Asn Tyr Ala Ala Ser Tyr 2870 2875 2880 Asn Lys Tyr Lys Tyr Tyr Ser Gly Ser Ala Ser Glu Ala Asp Tyr 2885 2890 2895 Arg Cys Ala Cys Tyr Ala His Leu Ala Lys Ala Met Leu Asp Tyr 2900 2905 2910 Ala Lys Asp His Asn Asp Met Leu Tyr Ser Pro Pro Thr Ile Ser 2915 2920 2925 Tyr Asn Ser Thr Leu Gln Ser Gly Leu Lys Lys Met Ala Gln Pro 2930 2935 2940 Ser Gly Cys Val Glu Arg Cys Val Val Arg Val Cys Tyr Gly Ser 2945 2950 2955 Thr Val Leu Asn Gly Val Trp Leu Gly Asp Thr Val Thr Cys Pro 2960 2965 2970 Arg His Val Ile Ala Pro Ser Thr Thr Val Leu Ile Asp Tyr Asp 2975 2980 2985 His Ala Tyr Ser Thr Met Arg Leu His Asn Phe Ser Val Ser His 2990 2995 3000 Asn Gly Val Phe Leu Gly Val Val Gly Val Thr Met His Gly Ser 3005 3010 3015 Val Leu Arg Ile Lys Val Ser Gln Ser Asn Val His Thr Pro Lys 3020 3025 3030 His Val Phe Lys Thr Leu Lys Pro Gly Ala Ser Phe Asn Ile Leu 3035 3040 3045 Ala Cys Tyr Glu Gly Ile Ala Ser Gly Val Phe Gly Val Asn Leu 3050 3055 3060 Arg Thr Asn Phe Thr Ile Lys Gly Ser Phe Ile Asn Gly Ala Cys 3065 3070 3075 Gly Ser Pro Gly Tyr Asn Val Arg Asn Asp Gly Thr Val Glu Phe 3080 3085 3090 Cys Tyr Leu His Gln Ile Glu Leu Gly Ser Gly Ala His Val Gly 3095 3100 3105 Ser Asp Phe Thr Gly Ser Val Tyr Gly Asn Phe Asp Asp Gln Pro 3110 3115 3120 Ser Leu Gln Val Glu Ser Ala Asn Leu Met Leu Ser Asp Asn Val 3125 3130 3135 Val Ala Phe Leu Tyr Ala Ala Leu Leu Asn Gly Cys Arg Trp Trp 3140 3145 3150 Leu Arg Ser Thr Arg Val Asn Val Asp Gly Phe Asn Glu Trp Ala 3155 3160 3165 Met Ala Asn Gly Tyr Thr Ile Val Ser Ser Val Glu Cys Tyr Ser 3170 3175 3180 Ile Leu Ala Ala Lys Thr Gly Val Ser Val Glu Gln Leu Leu Ala 3185 3190 3195 Ser Ile Gln His Leu His Glu Gly Phe Gly Gly Lys Asn Ile Leu 3200 3205 3210 Gly Tyr Ser Ser Leu Cys Asp Glu Phe Thr Leu Ala Glu Val Val 3215 3220 3225 Lys Gln Met Tyr Gly Val Asn Leu Gln Ser Gly Lys Val Ile Phe 3230 3235 3240 Gly Leu Lys Thr Met Phe Leu Phe Ser Val Phe Phe Thr Met Phe 3245 3250 3255 Trp Ala Glu Leu Phe Ile Tyr Thr Asn Thr Ile Trp Ile Asn Pro 3260 3265 3270 Val Ile Leu Thr Pro Ile Phe Cys Leu Leu Leu Phe Leu Ser Leu 3275 3280 3285 Val Leu Thr Met Phe Leu Lys His Lys Phe Leu Phe Leu Gln Val 3290 3295 3300 Phe Leu Leu Pro Thr Val Ile Ala Thr Ala Leu Tyr Asn Cys Val 3305 3310 3315 Leu Asp Tyr Tyr Ile Val Lys Phe Leu Ala Asp His Phe Asn Tyr 3320 3325 3330 Asn Val Ser Val Leu Gln Met Asp Val Gln Gly Leu Val Asn Val 3335 3340 3345 Leu Val Cys Leu Phe Val Val Phe Leu His Thr Trp Arg Phe Ser 3350 3355 3360 Lys Glu Arg Phe Thr His Trp Phe Thr Tyr Val Cys Ser Leu Ile 3365 3370 3375 Ala Val Ala Tyr Thr Tyr Phe Tyr Ser Gly Asp Phe Leu Ser Leu 3380 3385 3390 Leu Val Met Phe Leu Cys Ala Ile Ser Ser Asp Trp Tyr Ile Gly 3395 3400 3405 Ala Ile Val Phe Arg Leu Ser Arg Leu Ile Ile Phe Phe Ser Pro 3410 3415 3420 Glu Ser Val Phe Ser Val Phe Gly Asp Val Lys Leu Thr Leu Val 3425 3430 3435 Val Tyr Leu Ile Cys Gly Tyr Leu Val Cys Thr Tyr Trp Gly Ile 3440 3445 3450 Leu Tyr Trp Phe Asn Arg Phe Phe Lys Cys Thr Met Gly Val Tyr 3455 3460 3465 Asp Phe Lys Val Ser Ala Ala Glu Phe Lys Tyr Met Val Ala Asn 3470 3475 3480 Gly Leu His Ala Pro Tyr Gly Pro Phe Asp Ala Leu Trp Leu Ser 3485 3490 3495 Phe Lys Leu Leu Gly Ile Gly Gly Asp Arg Cys Ile Lys Ile Ser 3500 3505 3510 Thr Val Gln Ser Lys Leu Thr Asp Leu Lys Cys Thr Asn Val Val 3515 3520 3525 Leu Leu Gly Cys Leu Ser Ser Met Asn Ile Ala Ala Asn Ser Ser 3530 3535 3540 Glu Trp Ala Tyr Cys Val Asp Leu His Asn Lys Ile Asn Leu Cys 3545 3550 3555 Asp Asp Pro Glu Lys Ala Gln Gly Met Leu Leu Ala Leu Leu Ala 3560 3565 3570 Phe Phe Leu Ser Lys His Ser Asp Phe Gly Leu Asp Gly Leu Ile 3575 3580 3585 Asp Ser Tyr Phe Asp Asn Ser Ser Thr Leu Gln Ser Val Ala Ser 3590 3595 3600 Ser Phe Val Ser Met Pro Ser Tyr Ile Ala Tyr Glu Asn Ala Arg 3605 3610 3615 Gln Ala Tyr Glu Asp Ala Ile Ala Asn Gly Ser Ser Ser Gln Leu 3620 3625 3630 Ile Lys Gln Leu Lys Arg Ala Met Asn Ile Ala Lys Ser Glu Phe 3635 3640 3645 Asp His Glu Ile Ser Val Gln Lys Lys Ile Asn Arg Met Ala Glu 3650 3655 3660 Gln Ala Ala Thr Gln Met Tyr Lys Glu Ala Arg Ser Val Asn Arg 3665 3670 3675 Lys Ser Lys Val Ile Ser Ala Met His Ser Leu Leu Phe Gly Met 3680 3685 3690 Leu Arg Arg Leu Asp Met Ser Ser Val Glu Thr Val Leu Asn Leu 3695 3700 3705 Ala Arg Asp Gly Val Val Pro Leu Ser Val Ile Pro Ala Thr Ser 3710 3715 3720 Ala Ser Lys Leu Thr Ile Val Ser Pro Asp Leu Glu Ser Tyr Ser 3725 3730 3735 Lys Ile Val Cys Asp Gly Ser Val His Tyr Ala Gly Val Val Trp 3740 3745 3750 Thr Leu Asn Asp Val Lys Asp Asn Asp Gly Arg Pro Val His Val 3755 3760 3765 Lys Glu Ile Thr Arg Glu Asn Val Glu Thr Leu Thr Trp Pro Leu 3770 3775 3780 Ile Leu Asn Cys Glu Arg Val Val Lys Leu Gln Asn Asn Glu Ile 3785 3790 3795 Met Pro Gly Lys Leu Lys Gln Lys Pro Met Lys Ala Glu Gly Asp 3800 3805 3810 Gly Gly Val Leu Gly Asp Gly Asn Ala Leu Tyr Asn Thr Glu Gly 3815 3820 3825 Gly Lys Thr Phe Met Tyr Ala Tyr Ile Ser Asn Lys Ala Asp Leu 3830 3835 3840 Lys Phe Val Lys Trp Glu Tyr Glu Gly Gly Cys Asn Thr Ile Glu 3845 3850 3855 Leu Asp Ser Pro Cys Arg Phe Met Val Glu Thr Pro Asn Gly Pro 3860 3865 3870 Gln Val Lys Tyr Leu Tyr Phe Val Lys Asn Leu Asn Thr Leu Arg 3875 3880 3885 Arg Gly Ala Val Leu Gly Phe Ile Gly Ala Thr Ile Arg Leu Gln 3890 3895 3900 Ala Gly Lys Gln Thr Glu Leu Ala Val Asn Ser Gly Leu Leu Thr 3905 3910 3915 Ala Cys Ala Phe Ser Val Asp Pro Ala Thr Thr Tyr Leu Glu Ala 3920 3925 3930 Val Lys His Gly Ala Lys Pro Val Ser Asn Cys Ile Lys Met Leu 3935 3940 3945 Ser Asn Gly Ala Gly Asn Gly Gln Ala Ile Thr Thr Ser Val Asp 3950 3955 3960 Ala Asn Thr Asn Gln Asp Ser Tyr Gly Gly Ala Ser Ile Cys Leu 3965 3970 3975 Tyr Cys Arg Ala His Val Pro His Pro Ser Met Asp Gly Tyr Cys 3980 3985 3990 Lys Phe Lys Gly Lys Cys Val Gln Val Pro Ile Gly Cys Leu Asp 3995 4000 4005 Pro Ile Arg Phe Cys Leu Glu Asn Asn Val Cys Asn Val Cys Gly 4010 4015 4020 Cys Trp Leu Gly His Gly Cys Ala Cys Asp Arg Thr Thr Ile Gln 4025 4030 4035 Ser Val Asp Ile Ser Tyr Leu Asn Glu Gln Gly Val Leu Val Gln 4040 4045 4050 Leu Asp 4055 <210> 15 <211> 4416 <212> PRT <213> murine hepatitis virus <220> <221> MISC_FEATURE <223> ORF 1A <400> 15 Met Ala Lys Met Gly Lys Tyr Gly Leu Gly Phe Lys Trp Ala Pro Glu 1 5 10 15 Phe Pro Trp Met Leu Pro Asn Ala Ser Glu Lys Leu Gly Ser Pro Glu 20 25 30 Arg Ser Glu Glu Asp Gly Phe Cys Pro Ser Ala Ala Gln Glu Pro Lys 35 40 45 Thr Lys Gly Lys Thr Leu Ile Asn His Val Arg Val Asp Cys Ser Arg 50 55 60 Leu Pro Ala Leu Glu Cys Cys Val Gln Ser Ala Ile Ile Arg Asp Ile 65 70 75 80 Phe Val Asp Glu Asp Pro Leu Asn Val Glu Ala Ser Thr Met Met Ala 85 90 95 Leu Gln Phe Gly Ser Ala Val Leu Val Lys Pro Ser Lys Arg Leu Ser 100 105 110 Ile Gln Ala Trp Ala Lys Leu Gly Val Leu Pro Lys Thr Pro Ala Met 115 120 125 Gly Leu Phe Lys Arg Phe Cys Leu Cys Asn Thr Arg Glu Cys Val Cys 130 135 140 Asp Ala His Val Ala Phe Gln Leu Phe Thr Val Gln Pro Asp Gly Val 145 150 155 160 Cys Leu Gly Asn Gly Arg Phe Ile Gly Trp Phe Val Pro Val Thr Ala 165 170 175 Ile Pro Ala Tyr Ala Lys Gln Trp Leu Gln Pro Trp Ser Ile Leu Leu 180 185 190 Arg Lys Gly Gly Asn Lys Gly Ser Val Thr Ser Gly His Phe Arg Arg 195 200 205 Ala Val Thr Met Pro Val Tyr Asp Phe Asn Val Glu Asp Ala Cys Glu 210 215 220 Glu Val His Leu Asn Pro Lys Gly Lys Tyr Ser Arg Lys Ala Tyr Ala 225 230 235 240 Leu Leu Lys Gly Tyr Arg Gly Val Lys Ser Ile Leu Phe Leu Asp Gln 245 250 255 Tyr Gly Cys Asp Tyr Thr Gly Arg Leu Ala Lys Gly Leu Glu Asp Tyr 260 265 270 Gly Asp Cys Thr Leu Glu Glu Met Lys Glu Leu Phe Pro Val Trp Cys 275 280 285 Asp Ser Leu Asp Asn Glu Val Val Val Ala Trp His Val Asp Arg Asp 290 295 300 Pro Arg Ala Val Met Arg Leu Gln Thr Leu Ala Thr Ile Arg Ser Ile 305 310 315 320 Gly Tyr Val Gly Gln Pro Thr Glu Asp Leu Val Asp Gly Asp Val Val 325 330 335 Val Arg Glu Pro Ala His Leu Leu Ala Ala Asn Ala Ile Val Lys Arg 340 345 350 Leu Pro Arg Leu Val Glu Thr Met Leu Tyr Thr Asp Ser Ser Val Thr 355 360 365 Glu Phe Cys Tyr Lys Thr Lys Leu Cys Asp Cys Gly Phe Ile Thr Gln 370 375 380 Phe Gly Tyr Val Asp Cys Cys Gly Asp Ala Cys Asp Phe Arg Gly Trp 385 390 395 400 Val Pro Gly Asn Met Met Asp Gly Phe Leu Cys Pro Gly Cys Ser Lys 405 410 415 Ser Tyr Met Pro Trp Glu Leu Glu Ala Gln Ser Ser Gly Val Ile Pro 420 425 430 Lys Gly Gly Val Leu Phe Thr Gln Ser Thr Asp Thr Val Asn Arg Glu 435 440 445 Ser Phe Lys Leu Tyr Gly His Ala Val Val Pro Phe Gly Ser Ala Val 450 455 460 Tyr Trp Ser Pro Tyr Pro Gly Met Trp Leu Pro Val Ile Trp Ser Ser 465 470 475 480 Val Lys Ser Tyr Ala Asp Leu Thr Tyr Thr Gly Val Val Gly Cys Lys 485 490 495 Ala Ile Val Gln Glu Thr Asp Ala Ile Cys Arg Ser Leu Tyr Met Asp 500 505 510 Tyr Val Gln His Lys Cys Gly Asn Leu Glu Gln Arg Ala Ile Leu Gly 515 520 525 Leu Asp Asp Val Tyr His Arg Gln Leu Leu Val Asn Arg Gly Asp Tyr 530 535 540 Ser Leu Leu Leu Glu Asn Val Asp Leu Phe Val Lys Arg Arg Ala Glu 545 550 555 560 Phe Ala Cys Lys Phe Ala Thr Cys Gly Asp Gly Leu Val Pro Leu Leu 565 570 575 Leu Asp Gly Leu Val Pro Arg Ser Tyr Tyr Leu Ile Lys Ser Gly Gln 580 585 590 Ala Phe Thr Ser Met Met Val Asn Phe Ser His Glu Val Thr Asp Met 595 600 605 Cys Met Asp Met Ala Leu Leu Phe Met His Asp Val Lys Val Ala Thr 610 615 620 Lys Tyr Val Lys Lys Val Thr Gly Lys Leu Ala Val Arg Phe Lys Ala 625 630 635 640 Leu Gly Val Ala Val Val Arg Lys Ile Thr Glu Trp Phe Asp Leu Ala 645 650 655 Val Asp Thr Ala Ala Ser Ala Ala Gly Trp Leu Cys Tyr Gln Leu Val 660 665 670 Asn Gly Leu Phe Ala Val Ala Asn Gly Gly Ile Thr Phe Leu Ser Asp 675 680 685 Val Pro Glu Leu Val Lys Asn Phe Val Asp Lys Phe Lys Val Phe Phe 690 695 700 Lys Val Leu Ile Asp Ser Met Ser Val Ser Val Leu Ser Gly Leu Thr 705 710 715 720 Val Val Lys Thr Ala Ser Asn Arg Val Cys Leu Ala Gly Cys Lys Val 725 730 735 Tyr Glu Val Val Gln Lys Arg Leu Ser Ala Tyr Val Met Pro Val Gly 740 745 750 Cys Asn Glu Ala Thr Cys Leu Val Gly Glu Ile Glu Pro Ala Val Val 755 760 765 Glu Asp Asp Val Val Asp Val Val Lys Ala Pro Leu Thr Tyr Gln Gly 770 775 780 Cys Cys Lys Pro Pro Thr Ser Phe Glu Lys Ile Cys Val Val Asp Lys 785 790 795 800 Leu Tyr Met Ala Lys Cys Gly Asp Gln Phe Tyr Pro Val Val Val Asp 805 810 815 Asn Asp Thr Ile Gly Val Leu Asp Gln Cys Trp Arg Phe Pro Cys Ala 820 825 830 Gly Lys Lys Val Glu Phe Asn Asp Lys Pro Lys Val Lys Glu Ile Pro 835 840 845 Ser Thr Arg Lys Ile Lys Ile Asn Phe Ala Leu Asp Ala Thr Phe Asp 850 855 860 Ser Val Leu Ser Lys Ala Cys Ser Glu Phe Glu Val Asp Lys Asp Val 865 870 875 880 Thr Leu Asp Glu Leu Leu Asp Val Val Leu Asp Ala Val Glu Ser Thr 885 890 895 Leu Ser Pro Cys Lys Glu His Asp Val Ile Gly Thr Lys Val Cys Ala 900 905 910 Leu Leu Asn Arg Leu Ala Glu Asp Tyr Val Tyr Leu Phe Asp Glu Gly 915 920 925 Gly Glu Glu Val Ile Ala Pro Lys Met Tyr Cys Ser Phe Ser Ala Pro 930 935 940 Asp Asp Glu Asp Cys Val Ala Ala Asp Val Val Asp Ala Asp Glu Asn 945 950 955 960 Gln Gly Asp Asp Ala Asp Asp Ser Ala Ala Leu Val Thr Asp Thr Gln 965 970 975 Glu Glu Asp Gly Val Ala Lys Gly Gln Val Gly Val Ala Glu Ser Asp 980 985 990 Ala Arg Leu Asp Gln Val Glu Ala Phe Asp Ile Glu Lys Val Glu Asp 995 1000 1005 Pro Ile Leu Asn Glu Leu Ser Ala Glu Leu Asn Ala Pro Ala Asp 1010 1015 1020 Lys Thr Tyr Glu Asp Val Leu Ala Phe Asp Ala Ile Tyr Ser Glu 1025 1030 1035 Ala Leu Ser Ala Phe Tyr Ala Val Pro Gly Asp Glu Thr His Phe 1040 1045 1050 Lys Val Cys Gly Phe Tyr Ser Pro Ala Ile Glu Arg Thr Asn Cys 1055 1060 1065 Trp Leu Arg Ser Thr Leu Ile Val Met Gln Ser Leu Pro Leu Glu 1070 1075 1080 Phe Lys Asp Leu Glu Met Gln Lys Leu Trp Leu Ser Tyr Lys Ser 1085 1090 1095 Ser Tyr Asn Lys Glu Phe Val Asp Lys Leu Val Lys Ser Val Pro 1100 1105 1110 Lys Ser Ile Ile Leu Pro Gln Gly Gly Tyr Val Ala Asp Phe Ala 1115 1120 1125 Tyr Phe Phe Leu Ser Gln Cys Ser Phe Lys Ala Tyr Ala Asn Trp 1130 1135 1140 Arg Cys Leu Lys Cys Asp Met Asp Leu Lys Leu Gln Gly Leu Asp 1145 1150 1155 Ala Met Phe Phe Tyr Gly Asp Val Val Ser His Val Cys Lys Cys 1160 1165 1170 Gly Thr Gly Met Thr Leu Leu Ser Ala Asp Ile Pro Tyr Thr Leu 1175 1180 1185 His Phe Gly Leu Arg Asp Asp Lys Phe Cys Ala Phe Tyr Thr Pro 1190 1195 1200 Arg Lys Val Phe Arg Ala Ala Cys Val Val Asp Val Asn Asp Cys 1205 1210 1215 His Ser Met Ala Val Val Asp Gly Lys Gln Ile Asp Gly Lys Val 1220 1225 1230 Val Thr Lys Phe Asn Gly Asp Lys Tyr Asp Phe Met Val Gly His 1235 1240 1245 Gly Met Ala Phe Ser Met Ser Ala Phe Glu Ile Ala Gln Leu Tyr 1250 1255 1260 Gly Ser Cys Ile Thr Pro Asn Val Cys Phe Val Lys Gly Asp Val 1265 1270 1275 Ile Lys Val Leu Arg Arg Val Gly Ala Glu Val Ile Val Asn Pro 1280 1285 1290 Ala Asn Gly Arg Met Ala His Gly Ala Gly Val Ala Gly Ala Ile 1295 1300 1305 Ala Lys Ala Ala Gly Lys Ser Phe Ile Lys Glu Thr Ala Asp Met 1310 1315 1320 Val Lys Asn Gln Gly Val Cys Gln Val Gly Glu Cys Tyr Glu Ser 1325 1330 1335 Thr Gly Gly Asn Leu Cys Lys Thr Val Leu Asn Ile Val Gly Pro 1340 1345 1350 Asp Ala Arg Gly His Gly Lys Gln Cys Tyr Ser Phe Leu Glu Arg 1355 1360 1365 Ala Tyr Gln His Ile Asn Lys Cys Asp Asp Val Val Thr Thr Leu 1370 1375 1380 Ile Ser Ala Gly Ile Phe Ser Val Pro Thr Asp Val Ser Leu Thr 1385 1390 1395 Tyr Leu Ile Gly Val Val Thr Lys Asn Val Ile Leu Val Ser Asn 1400 1405 1410 Asn Lys Asp Asp Phe Asp Val Ile Glu Lys Cys Gln Val Thr Ser 1415 1420 1425 Ile Ala Gly Thr Lys Ala Leu Ser Leu Gln Leu Ala Lys Asn Leu 1430 1435 1440 Cys Arg Asp Val Lys Phe Glu Thr Asn Ala Cys Asp Ser Leu Phe 1445 1450 1455 Ser Asp Ser Cys Phe Val Ser Ser Tyr Asp Val Leu Gln Glu Val 1460 1465 1470 Glu Leu Leu Arg His Asp Ile Gln Leu Asp Asp Asp Ala Arg Val 1475 1480 1485 Phe Val Gln Ala His Met Asp Asn Leu Pro Ala Asp Trp Arg Leu 1490 1495 1500 Val Asn Lys Phe Asp Ser Val Asp Gly Val Arg Thr Val Lys Tyr 1505 1510 1515 Phe Glu Cys Pro Gly Glu Ile Phe Val Ser Ser Gln Gly Lys Lys 1520 1525 1530 Phe Gly Tyr Val Gln Asn Gly Ser Phe Lys Val Ala Ser Val Ser 1535 1540 1545 Gln Ile Arg Ala Leu Leu Ala Asn Lys Val Asp Val Leu Cys Thr 1550 1555 1560 Val Asp Gly Val Asn Phe Arg Ser Cys Cys Val Ala Glu Gly Glu 1565 1570 1575 Val Phe Gly Lys Thr Leu Gly Ser Val Phe Cys Asp Gly Ile Asn 1580 1585 1590 Val Thr Lys Val Arg Cys Ser Ala Ile His Lys Gly Lys Val Phe 1595 1600 1605 Phe Gln Tyr Ser Gly Leu Ser Ala Ala Asp Leu Val Ala Val Thr 1610 1615 1620 Asp Ala Phe Gly Phe Asp Glu Pro Gln Leu Leu Lys Tyr Tyr Asn 1625 1630 1635 Met Leu Gly Met Cys Lys Trp Pro Val Val Val Cys Gly Asn Tyr 1640 1645 1650 Phe Ala Phe Lys Gln Ser Asn Asn Asn Cys Tyr Ile Asn Val Ala 1655 1660 1665 Cys Leu Met Leu Gln His Leu Ser Leu Lys Phe His Lys Trp Gln 1670 1675 1680 Trp Gln Glu Ala Trp Asn Glu Phe Arg Ser Gly Lys Pro Leu Arg 1685 1690 1695 Phe Val Ser Leu Val Leu Ala Lys Gly Ser Phe Lys Phe Asn Glu 1700 1705 1710 Pro Ser Asp Ser Thr Asp Phe Met Arg Val Val Leu Arg Glu Ala 1715 1720 1725 Asp Leu Ser Gly Ala Thr Cys Asp Phe Glu Phe Val Cys Lys Cys 1730 1735 1740 Gly Val Lys Gln Glu Gln Arg Lys Gly Val Asp Ala Val Met His 1745 1750 1755 Phe Gly Thr Leu Asp Lys Gly Asp Leu Ala Lys Gly Tyr Thr Ile 1760 1765 1770 Ala Cys Thr Cys Gly Asn Lys Leu Val His Cys Thr Gln Leu Asn 1775 1780 1785 Val Pro Phe Leu Ile Cys Ser Asn Lys Pro Glu Gly Lys Lys Leu 1790 1795 1800 Pro Asp Asp Val Val Ala Ala Asn Ile Phe Thr Gly Gly Ser Leu 1805 1810 1815 Gly His Tyr Thr His Val Lys Cys Lys Pro Lys Tyr Gln Leu Tyr 1820 1825 1830 Asp Ala Cys Asn Val Ser Lys Val Ser Glu Ala Lys Gly Asn Phe 1835 1840 1845 Thr Asp Cys Leu Tyr Leu Lys Asn Leu Lys Gln Thr Phe Ser Ser 1850 1855 1860 Lys Leu Thr Thr Phe Tyr Leu Asp Asp Val Lys Cys Val Glu Tyr 1865 1870 1875 Asn Pro Asp Leu Ser Gln Tyr Tyr Cys Glu Ser Gly Lys Tyr Tyr 1880 1885 1890 Thr Lys Pro Ile Ile Lys Ala Gln Phe Arg Thr Phe Glu Lys Val 1895 1900 1905 Glu Gly Val Tyr Thr Asn Phe Lys Leu Val Gly His Ser Ile Ala 1910 1915 1920 Glu Lys Phe Asn Ala Lys Leu Gly Phe Asp Cys Asn Ser Pro Phe 1925 1930 1935 Thr Glu Tyr Lys Ile Thr Glu Trp Pro Thr Ala Thr Gly Asp Val 1940 1945 1950 Val Leu Ala Ser Asp Asp Leu Tyr Val Ser Arg Tyr Ser Gly Gly 1955 1960 1965 Cys Val Thr Phe Gly Lys Pro Val Ile Trp Leu Gly His Glu Glu 1970 1975 1980 Ala Ser Leu Lys Ser Leu Thr Tyr Phe Asn Arg Pro Ser Val Val 1985 1990 1995 Cys Glu Asn Lys Phe Asn Val Leu Pro Val Asp Val Ser Glu Pro 2000 2005 2010 Thr Asp Lys Gly Pro Val Pro Ala Ala Val Leu Val Thr Gly Ala 2015 2020 2025 Leu Ser Gly Ala Ala Thr Ala Pro Gly Thr Ala Lys Glu Gln Lys 2030 2035 2040 Val Cys Ala Ser Asp Ser Val Val Asp Gln Val Val Ser Gly Phe 2045 2050 2055 Leu Ser Asp Leu Ser Gly Ala Thr Val Asp Val Lys Glu Val Lys 2060 2065 2070 Leu Asn Gly Val Lys Lys Pro Ile Lys Val Glu Asp Ser Val Val 2075 2080 2085 Val Asn Asp Pro Thr Ser Glu Thr Lys Val Val Lys Ser Leu Ser 2090 2095 2100 Ile Val Asp Val Tyr Asp Met Phe Leu Thr Gly Cys Arg Tyr Val 2105 2110 2115 Val Trp Met Ala Asn Glu Leu Ser Arg Leu Val Asn Ser Pro Thr 2120 2125 2130 Val Arg Glu Tyr Val Lys Trp Gly Met Thr Lys Ile Val Ile Pro 2135 2140 2145 Ala Lys Leu Val Leu Leu Arg Asp Glu Lys Gln Glu Phe Val Ala 2150 2155 2160 Pro Lys Val Val Lys Ala Lys Val Ile Ala Cys Tyr Ser Ala Val 2165 2170 2175 Lys Trp Phe Phe Leu Tyr Cys Phe Ser Trp Ile Lys Phe Asn Thr 2180 2185 2190 Asp Asn Lys Val Ile Tyr Thr Thr Glu Val Ala Ser Lys Leu Thr 2195 2200 2205 Phe Asn Leu Cys Cys Leu Ala Phe Lys Asn Ala Leu Gln Thr Phe 2210 2215 2220 Asn Trp Asn Val Val Ser Arg Gly Phe Phe Leu Val Ala Thr Val 2225 2230 2235 Phe Leu Leu Trp Phe Asn Phe Leu Tyr Ala Asn Val Ile Leu Ser 2240 2245 2250 Asp Phe Tyr Leu Pro Asn Ile Gly Phe Phe Pro Thr Phe Val Gly 2255 2260 2265 Gln Ile Val Ala Trp Val Lys Thr Thr Phe Gly Ile Phe Thr Leu 2270 2275 2280 Cys Asp Leu Tyr Gln Val Ser Asp Val Gly Tyr Arg Ser Ser Phe 2285 2290 2295 Cys Asn Gly Ser Met Val Cys Glu Leu Cys Phe Ser Gly Phe Asp 2300 2305 2310 Met Leu Asp Asn Tyr Asp Ala Ile Asn Val Val Gln His Val Val 2315 2320 2325 Asp Arg Arg Val Ser Phe Asp Tyr Ile Ser Leu Phe Lys Leu Val 2330 2335 2340 Val Glu Leu Val Ile Gly Tyr Ser Leu Tyr Thr Val Cys Phe Tyr 2345 2350 2355 Pro Leu Phe Gly Leu Ile Gly Met Gln Leu Leu Thr Thr Trp Leu 2360 2365 2370 Pro Glu Phe Phe Met Leu Glu Thr Met His Trp Ser Ala Arg Phe 2375 2380 2385 Phe Val Phe Val Ala Asn Met Leu Pro Ala Phe Thr Leu Leu Arg 2390 2395 2400 Phe Tyr Ile Val Val Thr Ala Met Tyr Lys Ile Phe Cys Leu Cys 2405 2410 2415 Arg His Val Met Tyr Gly Cys Ser Arg Pro Gly Cys Leu Phe Cys 2420 2425 2430 Tyr Lys Arg Asn Arg Ser Val Arg Val Lys Cys Ser Thr Val Val 2435 2440 2445 Gly Gly Thr Leu Arg Tyr Tyr Asp Val Met Ala Asn Gly Gly Thr 2450 2455 2460 Gly Phe Cys Ala Lys His Gln Trp Asn Cys Leu Asn Cys Ser Ala 2465 2470 2475 Phe Gly Pro Gly Asn Thr Phe Ile Thr His Glu Ala Ala Ala Asp 2480 2485 2490 Leu Ser Lys Glu Leu Lys Arg Pro Val Asn Pro Thr Asp Ser Ala 2495 2500 2505 Tyr Tyr Leu Val Thr Glu Val Lys Gln Val Gly Cys Ser Met Arg 2510 2515 2520 Leu Phe Tyr Glu Arg Asp Gly Gln Arg Val Tyr Asp Asp Val Ser 2525 2530 2535 Ala Ser Leu Phe Val Asp Met Asn Gly Leu Leu His Ser Lys Val 2540 2545 2550 Lys Gly Val Pro Glu Thr His Val Val Val Val Glu Asn Glu Ala 2555 2560 2565 Asp Lys Ala Gly Phe Leu Asn Ala Ala Val Phe Tyr Ala Gln Ser 2570 2575 2580 Leu Tyr Arg Pro Met Leu Leu Val Glu Lys Lys Leu Ile Thr Thr 2585 2590 2595 Ala Asn Thr Gly Leu Ser Val Ser Gln Thr Met Phe Asp Leu Tyr 2600 2605 2610 Val Asp Ser Leu Leu Gly Val Leu Asp Val Asp Arg Lys Ser Leu 2615 2620 2625 Thr Ser Phe Val Asn Ala Ala His Asn Ser Leu Lys Glu Gly Val 2630 2635 2640 Gln Leu Glu Gln Val Met Asp Thr Phe Ile Gly Cys Ala Arg Arg 2645 2650 2655 Lys Cys Ala Ile Asp Ser Asp Val Glu Thr Lys Ser Ile Thr Lys 2660 2665 2670 Ser Ile Met Ser Ala Val Asn Ala Gly Val Asp Phe Thr Asp Glu 2675 2680 2685 Ser Cys Asn Asn Leu Val Pro Thr Tyr Val Lys Ser Asp Thr Ile 2690 2695 2700 Val Ala Ala Asp Leu Gly Val Leu Ile Gln Asn Asn Ala Lys His 2705 2710 2715 Val Gln Ala Asn Val Ala Lys Ala Ala Asn Val Ala Cys Ile Trp 2720 2725 2730 Ser Val Asp Ala Phe Asn Gln Leu Ser Ala Asp Leu Gln His Arg 2735 2740 2745 Leu Arg Lys Ala Cys Ser Lys Thr Gly Leu Lys Ile Lys Leu Thr 2750 2755 2760 Tyr Asn Lys Gln Glu Ala Asn Val Pro Ile Leu Thr Thr Pro Phe 2765 2770 2775 Ser Leu Lys Gly Gly Ala Val Phe Ser Lys Val Leu Gln Trp Leu 2780 2785 2790 Phe Val Val Asn Leu Ile Cys Phe Ile Val Leu Trp Ala Leu Met 2795 2800 2805 Pro Thr Tyr Ala Val His Lys Ser Asp Met Gln Leu Pro Leu Tyr 2810 2815 2820 Ala Ser Phe Lys Val Ile Asp Asn Gly Val Leu Arg Asp Val Thr 2825 2830 2835 Val Thr Asp Ala Cys Phe Ala Asn Lys Phe Ile Gln Phe Asp Gln 2840 2845 2850 Trp Tyr Glu Ser Thr Phe Gly Leu Val Tyr Tyr Arg Asn Ser Arg 2855 2860 2865 Ala Cys Pro Val Val Val Ala Val Ile Asp Gln Asp Ile Gly Tyr 2870 2875 2880 Thr Leu Phe Asn Val Pro Thr Lys Val Leu Arg Tyr Gly Phe His 2885 2890 2895 Val Leu His Phe Ile Thr His Ala Phe Ala Thr Asp Ser Val Gln 2900 2905 2910 Cys Tyr Thr Pro His Met Gln Ile Pro Tyr Asp Asn Phe Tyr Ala 2915 2920 2925 Ser Gly Cys Val Leu Ser Ser Leu Cys Thr Met Leu Ala His Ala 2930 2935 2940 Asp Gly Thr Pro His Pro Tyr Cys Tyr Thr Glu Gly Ile Met His 2945 2950 2955 Asn Ala Ser Leu Tyr Asp Ser Leu Ala Pro His Val Arg Tyr Asn 2960 2965 2970 Leu Ala Asn Ser Asn Gly Tyr Ile Arg Phe Pro Glu Val Val Ser 2975 2980 2985 Glu Gly Ile Val Arg Ile Val Arg Thr Arg Ser Met Thr Tyr Cys 2990 2995 3000 Arg Val Gly Leu Cys Glu Asp Ala Glu Glu Gly Val Cys Phe Asn 3005 3010 3015 Phe Asn Ser Ser Trp Val Leu Asn Asn Pro Tyr Tyr Arg Ala Met 3020 3025 3030 Pro Gly Thr Phe Cys Gly Arg Asn Ala Phe Asp Leu Ile His Gln 3035 3040 3045 Val Leu Gly Gly Leu Val Arg Pro Ile Asp Phe Phe Ala Leu Thr 3050 3055 3060 Ala Ser Ser Val Ala Gly Ala Ile Leu Ala Ile Ile Val Val Leu 3065 3070 3075 Ala Phe Tyr Tyr Leu Ile Lys Leu Lys Arg Ala Phe Gly Asp Tyr 3080 3085 3090 Thr Ser Val Val Val Ile Asn Val Ile Val Trp Cys Ile Asn Phe 3095 3100 3105 Leu Met Leu Phe Val Phe Gln Val Tyr Pro Thr Leu Ser Cys Leu 3110 3115 3120 Tyr Ala Cys Phe Tyr Phe Tyr Thr Thr Leu Tyr Phe Pro Ser Glu 3125 3130 3135 Ile Ser Val Val Met His Leu Gln Trp Leu Val Met Tyr Gly Ala 3140 3145 3150 Ile Met Pro Leu Trp Phe Cys Ile Ile Tyr Val Ala Val Val Val 3155 3160 3165 Ser Asn His Ala Leu Trp Leu Phe Ser Tyr Cys Arg Lys Leu Gly 3170 3175 3180 Thr Glu Val Arg Ser Asp Gly Thr Phe Glu Glu Met Ser Leu Thr 3185 3190 3195 Thr Phe Met Ile Thr Lys Glu Ser Tyr Cys Lys Leu Lys Asn Ser 3200 3205 3210 Val Ser Asp Val Ala Phe Asn Arg Tyr Leu Ser Leu Tyr Asn Lys 3215 3220 3225 Tyr Arg Tyr Phe Ser Gly Lys Met Asp Thr Ala Ala Tyr Arg Glu 3230 3235 3240 Ala Ala Cys Ser Gln Leu Ala Lys Ala Met Glu Thr Phe Asn His 3245 3250 3255 Asn Asn Gly Asn Asp Val Leu Tyr Gln Pro Pro Thr Ala Ser Val 3260 3265 3270 Thr Thr Ser Phe Leu Gln Ser Gly Ile Val Lys Met Val Phe Pro 3275 3280 3285 Thr Ser Lys Val Glu Pro Cys Val Val Ser Val Thr Tyr Gly Asn 3290 3295 3300 Met Thr Leu Asn Gly Leu Trp Leu Asp Asp Lys Val Tyr Cys Pro 3305 3310 3315 Arg His Val Ile Cys Ser Ser Ala Asp Met Thr Asp Pro Asp Tyr 3320 3325 3330 Ser Asn Leu Leu Cys Arg Val Ile Ser Ser Asp Phe Cys Val Met 3335 3340 3345 Ser Gly Arg Met Ser Leu Thr Val Met Ser Tyr Gln Met Gln Gly 3350 3355 3360 Ser Leu Leu Val Leu Thr Val Thr Leu Gln Asn Pro Asn Thr Pro 3365 3370 3375 Lys Tyr Ser Phe Gly Val Val Lys Pro Gly Glu Thr Phe Thr Val 3380 3385 3390 Leu Ala Ala Tyr Asn Gly Lys Ser Gln Gly Ala Phe His Val Thr 3395 3400 3405 Met Arg Ser Ser Tyr Thr Ile Lys Gly Ser Phe Leu Cys Gly Ser 3410 3415 3420 Cys Gly Ser Val Gly Tyr Val Leu Thr Gly Asp Ser Val Arg Phe 3425 3430 3435 Val Tyr Met His Gln Leu Glu Leu Ser Thr Gly Cys His Thr Gly 3440 3445 3450 Thr Asp Phe Ser Gly Asn Phe Tyr Gly Pro Tyr Arg Asp Ala Gln 3455 3460 3465 Val Val Gln Leu Pro Val Gln Asp Tyr Thr Gln Thr Val Asn Val 3470 3475 3480 Val Ala Trp Leu Tyr Ala Ala Ile Leu Asn Arg Cys Asn Trp Phe 3485 3490 3495 Val Gln Ser Asp Ser Cys Ser Leu Glu Glu Phe Asn Val Trp Ala 3500 3505 3510 Met Thr Asn Gly Phe Ser Ser Ile Lys Ala Asp Leu Val Leu Asp 3515 3520 3525 Ala Leu Ala Ser Met Thr Gly Val Thr Val Glu Gln Ile Leu Ala 3530 3535 3540 Ala Ile Lys Arg Leu Tyr Ser Gly Phe Gln Gly Lys Gln Ile Leu 3545 3550 3555 Gly Ser Cys Val Leu Glu Asp Glu Leu Thr Pro Ser Asp Val Tyr 3560 3565 3570 Gln Gln Leu Ala Gly Val Lys Leu Gln Ser Lys Arg Thr Arg Val 3575 3580 3585 Val Lys Gly Thr Cys Cys Trp Ile Leu Ala Ser Thr Leu Leu Phe 3590 3595 3600 Cys Ser Ile Ile Ser Ala Phe Val Lys Trp Thr Met Phe Met Tyr 3605 3610 3615 Val Thr Thr His Met Leu Gly Val Thr Leu Cys Ala Leu Cys Phe 3620 3625 3630 Val Ser Phe Ala Met Leu Leu Val Lys His Lys His Leu Tyr Leu 3635 3640 3645 Thr Met Phe Ile Met Pro Val Leu Cys Thr Leu Phe Tyr Thr Asn 3650 3655 3660 Tyr Leu Val Val Tyr Lys Gln Ser Phe Arg Gly Leu Ala Tyr Ala 3665 3670 3675 Trp Leu Ser His Phe Val Pro Ala Val Asp Tyr Thr Tyr Met Asp 3680 3685 3690 Glu Val Leu Tyr Gly Val Val Leu Leu Val Ala Met Val Phe Val 3695 3700 3705 Thr Met Arg Ser Ile Asn His Asp Val Phe Ser Val Met Phe Leu 3710 3715 3720 Val Gly Arg Leu Val Ser Leu Val Ser Met Trp Tyr Phe Gly Ala 3725 3730 3735 Asn Leu Glu Glu Glu Val Leu Leu Phe Leu Thr Ser Leu Phe Gly 3740 3745 3750 Thr Tyr Thr Trp Thr Thr Met Leu Ser Leu Ala Thr Ala Lys Val 3755 3760 3765 Ile Ala Lys Trp Leu Ala Val Asn Val Leu Tyr Phe Thr Asp Val 3770 3775 3780 Pro Gln Val Lys Leu Val Leu Leu Ser Tyr Leu Cys Ile Gly Tyr 3785 3790 3795 Val Cys Cys Cys Tyr Trp Gly Val Leu Ser Leu Leu Asn Ser Ile 3800 3805 3810 Phe Arg Met Pro Leu Gly Val Tyr Asn Tyr Lys Ile Ser Val Gln 3815 3820 3825 Glu Leu Arg Tyr Met Asn Ala Asn Gly Leu Arg Pro Pro Arg Asn 3830 3835 3840 Ser Phe Glu Ala Leu Val Leu Asn Phe Lys Leu Leu Gly Ile Gly 3845 3850 3855 Gly Val Pro Val Ile Glu Val Ser Gln Ile Gln Ser Arg Leu Thr 3860 3865 3870 Asp Val Lys Cys Val Asn Val Val Leu Leu Asn Cys Leu Gln His 3875 3880 3885 Leu His Ile Ala Ser Ser Ser Lys Leu Trp Gln Tyr Cys Ser Thr 3890 3895 3900 Leu His Asn Glu Ile Leu Ala Thr Ser Asp Leu Ser Val Ala Phe 3905 3910 3915 Asp Lys Leu Ala Gln Leu Leu Val Val Leu Phe Ala Asn Pro Ala 3920 3925 3930 Ala Val Asp Ser Lys Cys Leu Ala Ser Ile Glu Glu Val Ser Asp 3935 3940 3945 Asp Tyr Val Arg Asp Ser Thr Val Leu Gln Ala Leu Gln Ser Glu 3950 3955 3960 Phe Val Asn Met Ala Ser Phe Val Glu Tyr Glu Leu Ala Lys Lys 3965 3970 3975 Asn Leu Asp Glu Ala Lys Ala Ser Gly Ser Ala Asn Gln Gln Gln 3980 3985 3990 Ile Lys Gln Leu Glu Lys Ala Cys Asn Ile Ala Lys Ser Ala Tyr 3995 4000 4005 Glu Arg Asp Arg Ala Val Ala Arg Lys Leu Glu Arg Met Ala Asp 4010 4015 4020 Leu Ala Leu Thr Asn Met Tyr Lys Glu Ala Arg Ile Asn Asp Lys 4025 4030 4035 Lys Ser Lys Val Val Ser Ala Leu Gln Thr Met Leu Phe Ser Met 4040 4045 4050 Ile Arg Lys Leu Asp Asn Gln Ala Leu Asn Ser Ile Leu Asp Asn 4055 4060 4065 Ala Val Lys Gly Cys Val Pro Leu Asn Ala Ile Pro Ser Leu Thr 4070 4075 4080 Ser Asn Thr Leu Thr Ile Ile Val Pro Asp Lys Gln Val Phe Asp 4085 4090 4095 Gln Val Val Asp Asn Val Tyr Val Thr Tyr Ala Gly Asn Val Trp 4100 4105 4110 His Ile Gln Ser Ile Gln Asp Ala Asp Gly Ala Val Lys Gln Leu 4115 4120 4125 Asn Glu Ile Asp Val Asn Ile Thr Trp Pro Leu Val Ile Ala Ala 4130 4135 4140 Asn Arg His Asn Glu Val Ser Ser Val Val Leu Gln Asn Asn Glu 4145 4150 4155 Leu Met Pro Gln Lys Leu Arg Thr Gln Val Val Asn Ser Gly Ser 4160 4165 4170 Asp Met Asn Cys Asn Thr Pro Thr Gln Cys Tyr Tyr Asn Thr Thr 4175 4180 4185 Gly Met Gly Lys Ile Val Tyr Ala Ile Leu Ser Asp Cys Asp Gly 4190 4195 4200 Leu Lys Tyr Thr Lys Ile Val Lys Glu Asp Gly Asn Cys Val Val 4205 4210 4215 Leu Glu Leu Asp Pro Pro Cys Lys Phe Ser Val Gln Asp Val Lys 4220 4225 4230 Gly Leu Lys Ile Lys Tyr Leu Tyr Phe Val Lys Gly Cys Asn Thr 4235 4240 4245 Leu Ala Arg Gly Trp Val Val Gly Thr Leu Ser Ser Thr Val Arg 4250 4255 4260 Leu Gln Ala Gly Thr Ala Thr Glu Tyr Ala Ser Asn Ser Ala Ile 4265 4270 4275 Arg Ser Leu Cys Ala Phe Ser Val Asp Pro Lys Lys Thr Tyr Leu 4280 4285 4290 Asp Tyr Ile Gln Gln Gly Gly Ala Pro Val Thr Asn Cys Val Lys 4295 4300 4305 Met Leu Cys Asp His Ala Gly Thr Gly Met Ala Ile Thr Ile Lys 4310 4315 4320 Pro Glu Ala Thr Thr Asn Gln Asp Ser Tyr Gly Gly Ala Ser Val 4325 4330 4335 Cys Ile Tyr Cys Arg Ser Arg Val Glu His Pro Asp Val Asp Gly 4340 4345 4350 Leu Cys Lys Leu Arg Gly Lys Phe Val Gln Val Pro Leu Gly Ile 4355 4360 4365 Lys Asp Pro Val Ser Tyr Val Leu Thr His Asp Val Cys Gln Val 4370 4375 4380 Cys Gly Phe Trp Arg Asp Gly Ser Cys Ser Cys Val Gly Thr Gly 4385 4390 4395 Ser Gln Phe Gln Ser Lys Asp Thr Asn Phe Leu Asn Gly Phe Gly 4400 4405 4410 Val Gln Val 4415 <210> 16 <211> 4373 <212> PRT <213> human coronavirus OC43 <220> <221> MISC_FEATURE <223> ORF 1A <400> 16 Met Ser Lys Ile Asn Lys Tyr Gly Leu Glu Leu His Trp Ala Pro Glu 1 5 10 15 Phe Pro Trp Met Phe Glu Asp Ala Glu Glu Lys Leu Asp Asn Pro Ser 20 25 30 Ser Ser Glu Val Asp Met Ile Cys Ser Thr Thr Ala Gln Lys Leu Glu 35 40 45 Thr Asp Gly Ile Cys Pro Glu Asn His Val Met Val Asp Cys Arg Arg 50 55 60 Leu Leu Lys Gln Glu Cys Cys Val Gln Ser Ser Leu Ile Arg Glu Ile 65 70 75 80 Val Met Asn Ala Ser Pro Tyr Asp Leu Glu Val Leu Leu Gln Asp Ala 85 90 95 Leu Gln Ser Arg Glu Ala Val Leu Val Thr Thr Pro Leu Gly Met Ser 100 105 110 Leu Glu Ala Cys Tyr Val Arg Gly Cys Asn Pro Lys Gly Trp Thr Met 115 120 125 Gly Leu Phe Arg Arg Arg Ser Val Cys Asn Thr Gly Arg Cys Thr Val 130 135 140 Asn Lys His Val Ala Tyr Gln Leu Tyr Met Ile Asp Pro Ala Gly Val 145 150 155 160 Cys Leu Gly Ala Gly Gln Phe Val Gly Trp Val Ile Pro Leu Ala Phe 165 170 175 Met Pro Val Gln Ser Arg Lys Phe Ile Val Pro Trp Val Met Tyr Leu 180 185 190 Arg Lys Arg Gly Glu Lys Gly Ala Tyr Asn Lys Asp His Gly Arg Gly 195 200 205 Gly Phe Gly His Val Tyr Asp Phe Lys Val Glu Asp Ala Tyr Asp Gln 210 215 220 Val His Asp Glu Pro Lys Gly Lys Phe Ser Lys Lys Ala Tyr Ala Leu 225 230 235 240 Ile Arg Gly Tyr Arg Gly Val Lys Pro Leu Leu Tyr Val Asp Gln Tyr 245 250 255 Gly Cys Asp Tyr Thr Gly Ser Leu Ala Asp Gly Leu Glu Ala Tyr Ala 260 265 270 Asp Lys Thr Leu Gln Glu Met Lys Ala Leu Phe Pro Thr Trp Ser Gln 275 280 285 Glu Leu Leu Phe Asp Val Ile Val Ala Trp His Val Val Arg Asp Pro 290 295 300 Arg Tyr Val Met Arg Leu Gln Ser Ala Ala Thr Ile Arg Ser Val Ala 305 310 315 320 Tyr Val Ala Asn Pro Thr Glu Asp Leu Cys Asp Gly Ser Val Val Ile 325 330 335 Lys Glu Pro Val His Val Tyr Ala Asp Asp Ser Ile Ile Leu Arg Gln 340 345 350 Tyr Asn Leu Val Asp Ile Met Ser His Phe Tyr Met Glu Ala Asp Thr 355 360 365 Val Val Asn Ala Phe Tyr Gly Val Ala Leu Lys Asp Cys Gly Phe Val 370 375 380 Met Gln Phe Gly Tyr Ile Asp Cys Glu Gln Asp Ser Cys Asp Phe Lys 385 390 395 400 Gly Trp Ile Pro Gly Asn Met Ile Asp Gly Phe Ala Cys Thr Thr Cys 405 410 415 Gly His Val Tyr Glu Val Gly Asp Leu Ile Ala Gln Ser Ser Gly Val 420 425 430 Leu Pro Val Asn Pro Val Leu His Thr Lys Ser Ala Ala Gly Tyr Gly 435 440 445 Gly Phe Gly Cys Lys Asp Ser Phe Thr Leu Tyr Gly Gln Thr Val Val 450 455 460 Tyr Phe Gly Gly Cys Val Tyr Trp Ser Pro Ala Arg Asn Ile Trp Ile 465 470 475 480 Pro Ile Leu Lys Ser Ser Val Lys Ser Tyr Asp Ser Leu Val Tyr Thr 485 490 495 Gly Val Leu Gly Cys Lys Ala Ile Val Lys Glu Thr Asn Leu Ile Cys 500 505 510 Lys Ala Leu Tyr Leu Asp Tyr Val Gln His Lys Cys Gly Asn Leu His 515 520 525 Gln Arg Glu Leu Leu Gly Val Ser Asp Val Trp His Lys Gln Leu Leu 530 535 540 Leu Asn Arg Gly Val Tyr Lys Pro Leu Leu Glu Asn Ile Asp Tyr Phe 545 550 555 560 Asn Met Arg Arg Ala Lys Phe Ser Leu Glu Thr Phe Thr Val Cys Ala 565 570 575 Asp Gly Phe Met Pro Phe Leu Leu Asp Asp Leu Val Pro Arg Ala Tyr 580 585 590 Tyr Leu Ala Val Ser Gly Gln Ala Phe Cys Asp Tyr Ala Asp Lys Leu 595 600 605 Cys His Ala Val Val Ser Lys Ser Lys Glu Leu Leu Asp Val Ser Leu 610 615 620 Asp Ser Leu Gly Ala Ala Ile His Tyr Leu Asn Ser Lys Ile Val Asp 625 630 635 640 Leu Ala Gln His Phe Ser Asp Phe Gly Thr Ser Phe Val Ser Lys Ile 645 650 655 Val His Phe Phe Lys Thr Phe Thr Thr Ser Thr Ala Leu Ala Phe Ala 660 665 670 Trp Val Leu Phe His Val Leu His Gly Ala Tyr Ile Val Val Glu Ser 675 680 685 Asp Ile Tyr Phe Val Lys Asn Ile Pro Arg Tyr Ala Ser Ala Val Ala 690 695 700 Gln Ala Phe Gln Ser Val Ala Lys Val Val Leu Asp Ser Leu Arg Val 705 710 715 720 Thr Phe Ile Asp Gly Leu Ser Cys Phe Lys Ile Gly Arg Arg Arg Ile 725 730 735 Cys Leu Ser Gly Arg Lys Ile Tyr Glu Val Glu Arg Gly Leu Leu His 740 745 750 Ser Ser Gln Leu Pro Leu Asp Val Tyr Asp Leu Thr Met Pro Ser Gln 755 760 765 Val Gln Lys Ala Lys Gln Lys Pro Ile Tyr Leu Lys Gly Ser Gly Ser 770 775 780 Asp Phe Ser Leu Ala Asp Ser Val Val Glu Val Val Thr Thr Ser Leu 785 790 795 800 Thr Pro Cys Gly Tyr Ser Glu Pro Pro Lys Val Ala Asp Lys Ile Cys 805 810 815 Ile Val Asp Asn Val Tyr Met Ala Lys Ala Gly Asp Lys Tyr Tyr Pro 820 825 830 Val Val Val Asp Asp His Val Gly Leu Leu Asp Gln Ala Trp Arg Val 835 840 845 Pro Cys Ala Gly Arg Arg Val Thr Phe Lys Glu Gln Pro Thr Val Lys 850 855 860 Glu Ile Ile Ser Met Pro Lys Ile Ile Lys Val Phe Tyr Glu Leu Asp 865 870 875 880 Asn Asp Phe Asn Thr Ile Leu Asn Thr Ala Cys Gly Val Phe Glu Val 885 890 895 Asp Asp Thr Val Asp Met Glu Glu Phe Tyr Ala Val Val Ile Asp Ala 900 905 910 Ile Glu Glu Lys Leu Ser Pro Cys Lys Glu Leu Glu Gly Val Gly Ala 915 920 925 Lys Val Ser Ala Phe Leu Gln Lys Leu Glu Asp Asn Pro Leu Phe Leu 930 935 940 Phe Asp Glu Ala Gly Glu Glu Val Leu Ala Pro Lys Leu Tyr Cys Ala 945 950 955 960 Phe Thr Ala Pro Glu Asp Asp Asp Phe Leu Glu Glu Ser Asp Val Glu 965 970 975 Glu Asp Asp Val Glu Gly Glu Glu Thr Asp Leu Thr Val Thr Ser Ala 980 985 990 Gly Gln Pro Cys Val Ala Ser Glu Gln Glu Glu Ser Ser Glu Val Leu 995 1000 1005 Glu Asp Thr Leu Asp Asp Gly Pro Ser Val Glu Thr Ser Asp Ser 1010 1015 1020 Gln Val Glu Glu Asp Val Glu Met Ser Asp Phe Val Asp Leu Glu 1025 1030 1035 Ser Val Ile Gln Asp Tyr Glu Asn Val Cys Phe Glu Phe Tyr Thr 1040 1045 1050 Thr Glu Pro Glu Phe Val Lys Val Leu Gly Leu Tyr Val Pro Lys 1055 1060 1065 Ala Thr Arg Asn Asn Cys Trp Leu Arg Ser Val Leu Ala Val Met 1070 1075 1080 Gln Lys Leu Pro Cys Gln Phe Lys Asp Lys Asn Leu Gln Asp Leu 1085 1090 1095 Trp Val Leu Tyr Lys Gln Gln Tyr Ser Gln Leu Phe Val Asp Thr 1100 1105 1110 Leu Val Asn Lys Ile Pro Ala Asn Ile Val Leu Pro Gln Gly Gly 1115 1120 1125 Tyr Val Ala Asp Phe Ala Tyr Trp Phe Leu Thr Leu Cys Asp Trp 1130 1135 1140 Gln Cys Val Ala Tyr Trp Lys Cys Ile Lys Cys Asp Leu Ala Leu 1145 1150 1155 Lys Leu Lys Gly Leu Asp Ala Met Phe Phe Tyr Gly Asp Val Val 1160 1165 1170 Ser His Ile Cys Lys Cys Gly Glu Ser Met Val Leu Ile Asp Val 1175 1180 1185 Asp Val Pro Phe Thr Ala His Phe Ala Leu Lys Asp Lys Leu Phe 1190 1195 1200 Cys Ala Phe Ile Thr Lys Arg Ile Val Tyr Lys Ala Ala Cys Val 1205 1210 1215 Val Asp Val Asn Asp Ser His Ser Met Ala Val Val Asp Gly Lys 1220 1225 1230 Gln Ile Asp Asp His Arg Ile Thr Ser Ile Thr Ser Asp Lys Phe 1235 1240 1245 Asp Phe Ile Ile Gly His Gly Met Ser Phe Ser Met Thr Thr Phe 1250 1255 1260 Glu Ile Ala Gln Leu Tyr Gly Ser Cys Ile Thr Pro Asn Val Cys 1265 1270 1275 Phe Val Lys Gly Asp Ile Ile Lys Val Ser Lys Leu Val Lys Ala 1280 1285 1290 Glu Val Val Val Asn Pro Ala Asn Gly His Met Ala His Gly Gly 1295 1300 1305 Gly Val Ala Lys Ala Ile Ala Val Ala Ala Gly Gln Gln Phe Val 1310 1315 1320 Lys Glu Thr Thr Asp Met Val Lys Ser Lys Gly Val Cys Ala Thr 1325 1330 1335 Gly Asp Cys Tyr Val Ser Thr Gly Gly Lys Leu Cys Lys Thr Val 1340 1345 1350 Leu Asn Val Val Gly Pro Asp Ala Arg Thr Gln Gly Lys Gln Ser 1355 1360 1365 Tyr Val Leu Leu Glu Arg Val Tyr Lys His Leu Asn Asn Tyr Asp 1370 1375 1380 Cys Val Val Thr Thr Leu Ile Ser Ala Gly Ile Phe Ser Val Pro 1385 1390 1395 Ser Asp Val Ser Leu Thr Tyr Leu Leu Gly Thr Ala Lys Lys Gln 1400 1405 1410 Val Val Leu Val Ser Asn Asn Gln Glu Asp Phe Asp Leu Ile Ser 1415 1420 1425 Lys Cys Gln Ile Thr Ala Val Glu Gly Thr Lys Lys Leu Ala Ala 1430 1435 1440 Arg Leu Ser Phe Asn Val Gly Arg Ser Ile Val Tyr Glu Thr Asp 1445 1450 1455 Ala Asn Lys Leu Ile Leu Ile Asn Asp Val Ala Phe Val Ser Thr 1460 1465 1470 Phe Asn Val Leu Gln Asp Val Leu Ser Leu Arg His Asp Ile Ala 1475 1480 1485 Leu Asp Asp Asp Ala Arg Thr Phe Val Gln Ser Asn Val Asp Val 1490 1495 1500 Val Pro Glu Gly Trp Arg Val Val Asn Lys Phe Tyr Gln Ile Asn 1505 1510 1515 Gly Val Arg Thr Val Lys Tyr Phe Glu Cys Thr Gly Gly Ile Asp 1520 1525 1530 Ile Cys Ser Gln Asp Lys Val Phe Gly Tyr Val Gln Gln Gly Ile 1535 1540 1545 Phe Asn Lys Ala Thr Val Ala Gln Ile Lys Ala Leu Phe Leu Asp 1550 1555 1560 Lys Val Asp Ile Leu Leu Thr Val Asp Gly Val Asn Phe Thr Asn 1565 1570 1575 Arg Phe Val Pro Val Gly Glu Ser Phe Gly Lys Ser Leu Gly Asn 1580 1585 1590 Val Phe Cys Asp Gly Val Asn Val Thr Lys His Lys Cys Asp Ile 1595 1600 1605 Asn Tyr Lys Gly Lys Val Phe Phe Gln Phe Asp Asn Leu Ser Ser 1610 1615 1620 Glu Asp Leu Lys Ala Val Arg Ser Ser Phe Asn Phe Asp Gln Lys 1625 1630 1635 Glu Leu Leu Ala Tyr Tyr Asn Met Leu Val Asn Cys Phe Lys Trp 1640 1645 1650 Gln Val Val Val Asn Gly Lys Tyr Phe Thr Phe Lys Gln Ala Asn 1655 1660 1665 Asn Asn Cys Phe Val Asn Val Ser Cys Leu Met Leu Gln Ser Leu 1670 1675 1680 His Leu Thr Phe Lys Ile Val Gln Trp Gln Glu Ala Trp Leu Glu 1685 1690 1695 Phe Arg Ser Gly Arg Pro Ala Arg Phe Val Ala Leu Val Leu Ala 1700 1705 1710 Lys Gly Gly Phe Lys Phe Gly Asp Pro Ala Asp Ser Arg Asp Phe 1715 1720 1725 Leu Arg Val Val Phe Ser Gln Val Asp Leu Thr Gly Ala Ile Cys 1730 1735 1740 Asp Phe Glu Ile Ala Cys Lys Cys Gly Val Lys Gln Glu Gln Arg 1745 1750 1755 Thr Gly Leu Asp Ala Val Met His Phe Gly Thr Leu Ser Arg Glu 1760 1765 1770 Asp Leu Glu Ile Gly Tyr Thr Val Asp Cys Ser Cys Gly Lys Lys 1775 1780 1785 Leu Ile His Cys Val Arg Phe Asp Val Pro Phe Leu Ile Cys Ser 1790 1795 1800 Asn Thr Pro Ala Ser Val Lys Leu Pro Lys Gly Val Gly Ser Ala 1805 1810 1815 Asn Ile Phe Ile Gly Asp Lys Val Gly His Tyr Val His Val Lys 1820 1825 1830 Cys Glu Gln Ser Tyr Gln Leu Tyr Asp Ala Ser Asn Val Lys Lys 1835 1840 1845 Val Thr Asp Val Thr Gly Lys Leu Ser Asp Cys Leu Tyr Leu Lys 1850 1855 1860 Asn Leu Lys Gln Thr Phe Lys Ser Val Leu Thr Thr Tyr Tyr Leu 1865 1870 1875 Asp Asp Val Lys Lys Ile Glu Tyr Lys Pro Asp Leu Ser Gln Tyr 1880 1885 1890 Tyr Cys Asp Gly Gly Lys Tyr Tyr Thr Gln Arg Ile Ile Lys Ala 1895 1900 1905 Gln Phe Lys Thr Phe Glu Lys Val Asp Gly Val Tyr Thr Asn Phe 1910 1915 1920 Lys Leu Ile Gly His Thr Val Cys Asp Ser Leu Asn Ala Lys Leu 1925 1930 1935 Gly Phe Asp Ser Ser Lys Glu Phe Val Glu Tyr Lys Ile Thr Glu 1940 1945 1950 Trp Pro Thr Ala Thr Gly Asp Val Val Leu Ala Thr Asp Asp Leu 1955 1960 1965 Tyr Val Lys Arg Tyr Glu Arg Gly Cys Ile Thr Phe Gly Lys Pro 1970 1975 1980 Val Ile Trp Leu Ser His Glu Lys Ala Ser Leu Asn Ser Leu Thr 1985 1990 1995 Tyr Phe Asn Arg Pro Ser Leu Val Asp Asp Asn Lys Phe Asp Val 2000 2005 2010 Leu Lys Val Asp Asp Val Asp Asp Gly Gly Asp Ser Ser Glu Ser 2015 2020 2025 Gly Ala Lys Glu Thr Lys Glu Ile Asn Ile Ile Lys Leu Ser Gly 2030 2035 2040 Val Lys Lys Pro Phe Lys Val Glu Asp Ser Val Ile Val Asn Asp 2045 2050 2055 Asp Thr Ser Glu Thr Lys Tyr Val Lys Ser Leu Ser Ile Val Asp 2060 2065 2070 Val Tyr Asp Met Trp Leu Thr Gly Cys Lys Tyr Val Val Arg Thr 2075 2080 2085 Ala Asn Ala Leu Ser Arg Ala Val Asn Val Pro Thr Ile Arg Lys 2090 2095 2100 Phe Ile Lys Phe Gly Met Thr Leu Val Ser Ile Pro Ile Asp Leu 2105 2110 2115 Leu Asn Leu Arg Glu Ile Lys Pro Ala Val Asn Val Val Lys Ala 2120 2125 2130 Val Arg Asn Lys Ile Ser Val Cys Phe Asn Phe Ile Lys Trp Leu 2135 2140 2145 Phe Val Leu Leu Phe Gly Trp Ile Lys Ile Ser Ala Asp Asn Lys 2150 2155 2160 Val Ile Tyr Thr Thr Glu Ile Ala Ser Lys Leu Thr Cys Lys Leu 2165 2170 2175 Val Ala Leu Ala Phe Lys Asn Ala Phe Leu Thr Phe Lys Trp Ser 2180 2185 2190 Met Val Ala Arg Gly Ala Cys Ile Ile Ala Thr Ile Phe Leu Leu 2195 2200 2205 Trp Phe Asn Phe Ile Tyr Ala Asn Val Ile Phe Ser Asp Phe Tyr 2210 2215 2220 Leu Pro Lys Ile Gly Phe Leu Pro Thr Phe Val Gly Lys Ile Ala 2225 2230 2235 Gln Trp Ile Lys Asn Thr Phe Ser Leu Val Thr Ile Cys Asp Leu 2240 2245 2250 Tyr Ser Met Gln Asp Val Gly Phe Lys Asn Gln Tyr Cys Asn Gly 2255 2260 2265 Ser Ile Ala Cys Gln Phe Cys Leu Ala Gly Phe Asp Met Leu Asp 2270 2275 2280 Asn Tyr Lys Ala Ile Asp Val Val Gln Tyr Glu Ala Asp Arg Arg 2285 2290 2295 Ala Phe Val Asp Tyr Thr Gly Val Leu Lys Ile Val Ile Glu Leu 2300 2305 2310 Ile Val Ser Tyr Ala Leu Tyr Thr Ala Trp Phe Tyr Pro Leu Phe 2315 2320 2325 Ala Leu Ile Ser Ile Gln Ile Leu Thr Thr Trp Leu Pro Glu Leu 2330 2335 2340 Phe Met Leu Ser Thr Leu His Trp Ser Phe Arg Leu Leu Val Ala 2345 2350 2355 Leu Ala Asn Met Leu Pro Ala His Val Phe Met Arg Phe Tyr Ile 2360 2365 2370 Ile Ile Ala Ser Phe Ile Lys Leu Phe Ser Leu Phe Arg His Val 2375 2380 2385 Ala Tyr Gly Cys Ser Lys Ser Gly Cys Leu Phe Cys Tyr Lys Arg 2390 2395 2400 Asn Arg Ser Leu Arg Val Lys Cys Ser Thr Ile Val Gly Gly Met 2405 2410 2415 Ile Arg Tyr Tyr Asp Val Met Ala Asn Gly Gly Thr Gly Phe Cys 2420 2425 2430 Ser Lys His Gln Trp Asn Cys Ile Asp Cys Asp Ser Tyr Lys Pro 2435 2440 2445 Gly Asn Thr Phe Ile Thr Val Glu Ala Ala Leu Asp Leu Ser Lys 2450 2455 2460 Glu Leu Lys Arg Pro Ile Gln Pro Thr Asp Val Ala Tyr His Thr 2465 2470 2475 Val Thr Asp Val Lys Gln Val Gly Cys Ser Met Arg Leu Phe Tyr 2480 2485 2490 Asp Arg Asp Gly Gln Arg Thr Tyr Asp Asp Val Asn Ala Ser Leu 2495 2500 2505 Phe Val Asp Tyr Ser Asn Leu Leu His Ser Lys Val Lys Ser Val 2510 2515 2520 Pro Asn Met His Val Val Val Val Glu Asn Asp Ala Asp Lys Ala 2525 2530 2535 Asn Phe Leu Asn Ala Ala Val Phe Tyr Ala Gln Ser Leu Phe Arg 2540 2545 2550 Pro Ile Leu Met Val Asp Lys Asn Leu Ile Thr Thr Ala Asn Thr 2555 2560 2565 Gly Thr Ser Val Thr Glu Thr Met Phe Asp Val Tyr Val Asp Thr 2570 2575 2580 Phe Leu Ser Met Phe Asp Val Asp Lys Lys Ser Leu Asn Ala Leu 2585 2590 2595 Ile Ala Thr Ala His Ser Ser Ile Lys Gln Gly Thr Gln Ile Tyr 2600 2605 2610 Lys Val Leu Asp Thr Phe Leu Ser Cys Ala Arg Lys Ser Cys Ser 2615 2620 2625 Ile Asp Ser Asp Val Asp Thr Lys Cys Leu Ala Asp Ser Val Met 2630 2635 2640 Ser Ala Val Ser Ala Gly Leu Glu Leu Thr Asp Glu Ser Cys Asn 2645 2650 2655 Asn Leu Val Pro Thr Tyr Leu Lys Ser Asp Asn Ile Val Ala Ala 2660 2665 2670 Asp Leu Gly Val Leu Ile Gln Asn Ser Ala Lys His Val Gln Gly 2675 2680 2685 Asn Val Ala Lys Ile Ala Gly Val Ser Cys Ile Trp Ser Val Asp 2690 2695 2700 Ala Phe Asn Gln Phe Ser Ser Asp Phe Gln His Lys Leu Lys Lys 2705 2710 2715 Ala Cys Cys Lys Thr Gly Leu Lys Leu Lys Leu Thr Tyr Asn Lys 2720 2725 2730 Gln Met Ala Asn Val Ser Val Leu Thr Thr Pro Phe Ser Leu Lys 2735 2740 2745 Gly Gly Ala Val Phe Ser Tyr Phe Val Tyr Val Cys Phe Val Leu 2750 2755 2760 Ser Leu Val Cys Phe Ile Gly Leu Trp Cys Leu Met Pro Thr Tyr 2765 2770 2775 Thr Val His Lys Ser Asp Phe Gln Leu Pro Val Tyr Ala Ser Tyr 2780 2785 2790 Lys Val Leu Asp Asn Gly Val Ile Arg Asp Val Ser Val Glu Asp 2795 2800 2805 Val Cys Phe Ala Asn Lys Phe Glu Gln Phe Asp Gln Trp Tyr Glu 2810 2815 2820 Ser Thr Phe Gly Leu Ser Tyr Tyr Ser Asn Ser Met Ala Cys Pro 2825 2830 2835 Ile Val Val Ala Val Ile Asp Gln Asp Phe Gly Ser Thr Val Phe 2840 2845 2850 Asn Val Pro Thr Lys Val Leu Arg Tyr Gly Tyr His Val Leu His 2855 2860 2865 Phe Ile Thr His Ala Leu Ser Ala Asp Gly Val Gln Cys Tyr Thr 2870 2875 2880 Pro His Ser Gln Ile Ser Tyr Ser Asn Phe Tyr Ala Ser Gly Cys 2885 2890 2895 Val Leu Ser Ser Ala Cys Thr Met Phe Thr Met Ala Asp Gly Ser 2900 2905 2910 Pro Gln Pro Tyr Cys Tyr Thr Glu Gly Leu Met Gln Asn Ala Ser 2915 2920 2925 Leu Tyr Ser Ser Leu Val Pro His Val Arg Tyr Asn Leu Ala Asn 2930 2935 2940 Ala Lys Gly Phe Ile Arg Phe Pro Glu Val Leu Arg Glu Gly Leu 2945 2950 2955 Val Arg Ile Val Arg Thr Arg Ser Met Ser Tyr Cys Arg Val Gly 2960 2965 2970 Leu Cys Glu Glu Ala Asp Glu Gly Ile Cys Phe Asn Phe Asn Gly 2975 2980 2985 Ser Trp Val Leu Asn Asn Asp Tyr Tyr Arg Ser Leu Pro Gly Thr 2990 2995 3000 Phe Cys Gly Arg Asp Val Phe Asp Leu Ile Tyr Gln Leu Phe Lys 3005 3010 3015 Gly Leu Ala Gln Pro Val Asp Phe Leu Ala Leu Thr Ala Ser Ser 3020 3025 3030 Ile Ala Gly Ala Ile Leu Ala Val Ile Val Val Leu Val Phe Tyr 3035 3040 3045 Tyr Leu Ile Lys Leu Lys Arg Ala Phe Gly Asp Tyr Thr Ser Val 3050 3055 3060 Val Phe Val Asn Val Ile Val Trp Cys Val Asn Phe Met Met Leu 3065 3070 3075 Phe Val Phe Gln Val Tyr Pro Ile Leu Ser Cys Val Tyr Ala Ile 3080 3085 3090 Cys Tyr Phe Tyr Ala Thr Leu Tyr Phe Pro Ser Glu Ile Ser Val 3095 3100 3105 Ile Met His Leu Gln Trp Leu Val Met Tyr Gly Thr Ile Met Pro 3110 3115 3120 Leu Trp Phe Cys Leu Leu Tyr Ile Ala Val Val Val Ser Asn His 3125 3130 3135 Ala Phe Trp Val Phe Ser Tyr Cys Arg Lys Leu Gly Thr Ser Val 3140 3145 3150 Arg Ser Asp Gly Thr Phe Glu Glu Met Ala Leu Thr Thr Phe Met 3155 3160 3165 Ile Thr Lys Asp Ser Tyr Cys Lys Leu Lys Asn Ser Leu Ser Asp 3170 3175 3180 Val Ala Phe Asn Arg Tyr Leu Ser Leu Tyr Asn Lys Tyr Arg Tyr 3185 3190 3195 Tyr Ser Gly Lys Met Asp Thr Ala Ala Tyr Arg Glu Ala Ala Cys 3200 3205 3210 Ser Gln Leu Ala Lys Ala Met Asp Thr Phe Thr Asn Asn Asn Gly 3215 3220 3225 Ser Asp Val Leu Tyr Gln Pro Pro Thr Ala Ser Val Ser Thr Ser 3230 3235 3240 Phe Leu Gln Ser Gly Ile Val Lys Met Val Asn Pro Thr Ser Lys 3245 3250 3255 Val Glu Pro Cys Val Val Ser Val Thr Tyr Gly Asn Met Thr Leu 3260 3265 3270 Asn Gly Leu Trp Leu Asp Asp Lys Val Tyr Cys Pro Arg His Val 3275 3280 3285 Ile Cys Ser Ala Ser Asp Met Thr Asn Pro Asp Tyr Thr Asn Leu 3290 3295 3300 Leu Cys Arg Val Thr Ser Ser Asp Phe Thr Val Leu Phe Asp Arg 3305 3310 3315 Leu Ser Leu Thr Val Met Ser Tyr Gln Met Arg Gly Cys Met Leu 3320 3325 3330 Val Leu Thr Val Thr Leu Gln Asn Ser Arg Thr Pro Lys Tyr Thr 3335 3340 3345 Phe Gly Val Val Lys Pro Gly Glu Thr Phe Thr Val Leu Ala Ala 3350 3355 3360 Tyr Asn Gly Lys Pro Gln Gly Ala Phe His Val Thr Met Arg Ser 3365 3370 3375 Ser Tyr Thr Ile Lys Gly Ser Phe Leu Cys Gly Ser Cys Gly Ser 3380 3385 3390 Val Gly Tyr Val Ile Met Gly Asp Cys Val Lys Phe Val Tyr Met 3395 3400 3405 His Gln Leu Glu Leu Ser Thr Gly Cys His Thr Gly Thr Asp Phe 3410 3415 3420 Asn Gly Asp Phe Tyr Gly Pro Tyr Lys Asp Ala Gln Val Val Gln 3425 3430 3435 Leu Leu Ile Gln Asp Tyr Ile Gln Ser Val Asn Phe Val Ala Trp 3440 3445 3450 Leu Tyr Ala Ala Ile Leu Asn Asn Cys Asn Trp Phe Val Gln Ser 3455 3460 3465 Asp Lys Cys Ser Val Glu Asp Phe Asn Val Trp Ala Leu Ser Asn 3470 3475 3480 Gly Phe Ser Gln Val Lys Ser Asp Leu Val Ile Asp Ala Leu Ala 3485 3490 3495 Ser Met Thr Gly Val Ser Leu Glu Thr Leu Leu Ala Ala Ile Lys 3500 3505 3510 Arg Leu Lys Asn Gly Phe Gln Gly Arg Gln Ile Met Gly Ser Cys 3515 3520 3525 Ser Phe Glu Asp Glu Leu Thr Pro Ser Asp Val Tyr Gln Gln Leu 3530 3535 3540 Ala Gly Ile Lys Leu Gln Ser Lys Arg Thr Arg Leu Phe Lys Gly 3545 3550 3555 Thr Val Cys Trp Ile Met Ala Ser Thr Phe Leu Phe Ser Cys Ile 3560 3565 3570 Ile Thr Ala Phe Val Lys Trp Thr Met Phe Met Tyr Val Thr Thr 3575 3580 3585 Asn Met Phe Ser Ile Thr Phe Cys Ala Leu Cys Val Ile Ser Leu 3590 3595 3600 Ala Met Leu Leu Val Lys His Lys His Leu Tyr Leu Thr Met Tyr 3605 3610 3615 Ile Thr Pro Val Leu Phe Thr Leu Leu Tyr Asn Asn Tyr Leu Val 3620 3625 3630 Val Tyr Lys His Thr Phe Arg Gly Tyr Val Tyr Ala Trp Leu Ser 3635 3640 3645 Tyr Tyr Val Pro Ser Val Glu Tyr Thr Tyr Thr Asp Glu Val Ile 3650 3655 3660 Tyr Gly Met Leu Leu Leu Val Gly Met Val Phe Val Thr Leu Arg 3665 3670 3675 Ser Ile Asn His Asp Leu Phe Ser Phe Ile Met Phe Val Gly Arg 3680 3685 3690 Leu Ile Ser Val Phe Ser Leu Trp Tyr Lys Gly Ser Asn Leu Glu 3695 3700 3705 Glu Glu Ile Leu Leu Met Leu Ala Ser Leu Phe Gly Thr Tyr Thr 3710 3715 3720 Trp Thr Thr Val Leu Ser Met Ala Val Ala Lys Val Ile Ala Lys 3725 3730 3735 Trp Val Ala Val Asn Val Leu Tyr Phe Thr Asp Ile Pro Gln Ile 3740 3745 3750 Lys Ile Val Leu Leu Cys Tyr Leu Phe Ile Gly Tyr Ile Ile Ser 3755 3760 3765 Cys Tyr Trp Gly Leu Phe Ser Leu Met Asn Ser Leu Phe Arg Met 3770 3775 3780 Pro Leu Gly Val Tyr Asn Tyr Lys Ile Ser Val Gln Glu Leu Arg 3785 3790 3795 Tyr Met Asn Ala Asn Gly Leu Arg Pro Pro Lys Asn Ser Phe Glu 3800 3805 3810 Ala Leu Met Leu Asn Phe Lys Leu Leu Gly Ile Gly Gly Val Pro 3815 3820 3825 Ile Ile Glu Val Ser Gln Phe Gln Ser Lys Leu Thr Asp Val Lys 3830 3835 3840 Cys Ala Asn Val Val Leu Leu Asn Cys Leu Gln His Leu His Val 3845 3850 3855 Ala Ser Asn Ser Lys Leu Trp His Tyr Cys Ser Thr Leu His Asn 3860 3865 3870 Glu Ile Leu Ala Thr Ser Asp Leu Ser Val Ala Phe Glu Lys Leu 3875 3880 3885 Ala Gln Leu Leu Ile Val Leu Phe Ala Asn Pro Ala Ala Val Asp 3890 3895 3900 Ser Lys Cys Leu Thr Ser Ile Glu Glu Val Cys Asp Asp Tyr Ala 3905 3910 3915 Lys Asp Asn Thr Val Leu Gln Ala Leu Gln Ser Glu Phe Val Asn 3920 3925 3930 Met Ala Ser Phe Val Glu Tyr Glu Val Ala Lys Lys Asn Leu Asp 3935 3940 3945 Glu Ala Arg Phe Ser Gly Ser Ala Asn Gln Gln Gln Leu Lys Gln 3950 3955 3960 Leu Glu Lys Ala Cys Asn Ile Ala Lys Ser Ala Tyr Glu Arg Asp 3965 3970 3975 Arg Ala Val Ala Lys Lys Leu Glu Arg Met Ala Asp Leu Ala Leu 3980 3985 3990 Thr Asn Met Tyr Lys Glu Ala Arg Ile Asn Asp Lys Lys Ser Lys 3995 4000 4005 Val Val Ser Ala Leu Gln Thr Met Leu Phe Ser Met Val Arg Lys 4010 4015 4020 Leu Asp Asn Gln Ala Leu Asn Ser Ile Leu Asp Asn Ala Val Lys 4025 4030 4035 Gly Cys Val Pro Leu Asn Ala Ile Pro Ser Leu Ala Ala Asn Thr 4040 4045 4050 Leu Asn Ile Ile Val Pro Asp Lys Ser Val Tyr Asp Gln Val Val 4055 4060 4065 Asp Asn Val Tyr Val Thr Tyr Ala Gly Asn Val Trp Gln Ile Gln 4070 4075 4080 Thr Ile Gln Asp Ser Asp Gly Thr Asn Lys Gln Leu Asn Glu Ile 4085 4090 4095 Ser Asp Asp Cys Asn Trp Pro Leu Val Ile Ile Ala Asn Arg Tyr 4100 4105 4110 Asn Glu Val Ser Ala Thr Val Leu Gln Asn Asn Glu Leu Met Pro 4115 4120 4125 Ala Lys Leu Lys Ile Gln Val Val Asn Ser Gly Pro Asp Gln Thr 4130 4135 4140 Cys Asn Thr Pro Thr Gln Cys Tyr Tyr Asn Asn Ser Asn Asn Gly 4145 4150 4155 Lys Ile Val Tyr Ala Ile Leu Ser Asp Val Asp Gly Leu Lys Tyr 4160 4165 4170 Thr Lys Ile Leu Lys Asp Asp Gly Asn Phe Val Val Leu Glu Leu 4175 4180 4185 Asp Pro Pro Cys Lys Phe Thr Val Gln Asp Ala Lys Gly Leu Lys 4190 4195 4200 Ile Lys Tyr Leu Tyr Phe Val Lys Gly Cys Asn Thr Leu Ala Arg 4205 4210 4215 Gly Trp Val Val Gly Thr Ile Ser Ser Thr Val Arg Leu Gln Ala 4220 4225 4230 Gly Thr Ala Thr Glu Tyr Ala Ser Asn Ser Ser Ile Leu Ser Leu 4235 4240 4245 Cys Ala Phe Ser Val Asp Pro Lys Lys Thr Tyr Leu Asp Phe Ile 4250 4255 4260 Gln Gln Gly Gly Thr Pro Ile Ala Asn Cys Val Lys Met Leu Cys 4265 4270 4275 Asp His Ala Gly Thr Gly Met Ala Ile Thr Val Lys Pro Asp Ala 4280 4285 4290 Thr Thr Ser Gln Asp Ser Tyr Gly Gly Ala Ser Val Cys Ile Tyr 4295 4300 4305 Cys Arg Ala Arg Val Glu His Pro Asp Val Asp Gly Leu Cys Lys 4310 4315 4320 Leu Arg Gly Lys Phe Val Gln Val Pro Val Gly Ile Lys Asp Pro 4325 4330 4335 Val Ser Tyr Val Leu Thr His Asp Val Cys Arg Val Cys Gly Phe 4340 4345 4350 Trp Arg Asp Gly Ser Cys Ser Cys Val Ser Thr Asp Thr Thr Val 4355 4360 4365 Gln Ser Lys Asp Thr 4370 <210> 17 <211> 4102 <212> PRT <213> porcine epidemic diarrhea virus <220> <221> MISC_FEATURE <223> ORF 1A <400> 17 Met Ala Ser Asn His Val Thr Leu Ala Phe Ala Asn Asp Ala Glu Ile 1 5 10 15 Ser Ala Phe Gly Phe Cys Thr Ala Ser Glu Ala Val Ser Tyr Tyr Ser 20 25 30 Glu Ala Ala Ala Ser Gly Phe Met Gln Cys Arg Phe Val Ser Leu Asp 35 40 45 Leu Ala Asp Thr Val Glu Gly Leu Leu Pro Glu Asp Tyr Val Met Val 50 55 60 Val Ile Gly Thr Thr Lys Leu Ser Ala Tyr Val Asp Thr Phe Gly Ser 65 70 75 80 Arg Pro Arg Asn Ile Cys Gly Trp Leu Leu Phe Ser Asn Cys Asn Tyr 85 90 95 Phe Leu Glu Glu Leu Glu Leu Thr Phe Gly Arg Arg Gly Gly Asn Ile 100 105 110 Val Pro Val Asp Gln Tyr Met Cys Gly Ala Asp Gly Lys Pro Val Leu 115 120 125 Gln Glu Ser Glu Trp Glu Tyr Thr Asp Phe Phe Ala Asp Ser Glu Asp 130 135 140 Gly Gln Leu Asn Ile Ala Gly Ile Thr Tyr Val Lys Ala Trp Ile Val 145 150 155 160 Glu Arg Ser Asp Val Ser Tyr Ala Ser Gln Asn Leu Thr Ser Ile Lys 165 170 175 Ser Ile Thr Tyr Cys Ser Thr Tyr Glu His Thr Phe Leu Asp Gly Thr 180 185 190 Ala Met Lys Val Ala Arg Thr Pro Lys Ile Lys Lys Asn Val Val Leu 195 200 205 Ser Glu Pro Leu Ala Thr Ile Tyr Arg Glu Ile Gly Ser Pro Phe Val 210 215 220 Asp Asn Gly Ser Asp Ala Arg Ser Ile Ile Arg Arg Pro Val Phe Leu 225 230 235 240 His Ala Phe Val Lys Cys Lys Cys Gly Ser Tyr His Trp Thr Val Gly 245 250 255 Asp Trp Thr Ser Tyr Val Ser Thr Cys Cys Gly Phe Lys Cys Lys Pro 260 265 270 Val Leu Val Ala Ser Cys Ser Ala Met Pro Gly Ser Val Val Val Thr 275 280 285 Arg Ala Gly Ala Gly Thr Gly Val Lys Tyr Tyr Asn Asn Met Phe Leu 290 295 300 Arg His Val Ala Asp Ile Asp Gly Leu Ala Phe Trp Arg Ile Leu Lys 305 310 315 320 Val Gln Ser Lys Asp Asp Leu Ala Cys Ser Gly Lys Phe Leu Glu His 325 330 335 His Glu Glu Gly Phe Thr Asp Pro Cys Tyr Phe Leu Asn Asp Ser Ser 340 345 350 Leu Ala Thr Lys Leu Lys Phe Asp Ile Leu Ser Gly Lys Phe Ser Asp 355 360 365 Glu Val Lys Gln Ala Ile Ile Ala Gly His Val Val Val Gly Ser Ala 370 375 380 Leu Val Asp Ile Val Asp Asp Ala Leu Gly Gln Pro Trp Phe Ile Arg 385 390 395 400 Lys Leu Gly Asp Leu Ala Ser Ala Pro Trp Glu Gln Leu Lys Ala Val 405 410 415 Val Arg Gly Leu Gly Leu Leu Ser Asp Glu Val Val Leu Phe Gly Lys 420 425 430 Arg Leu Ser Cys Ala Thr Leu Ser Ile Val Asn Gly Val Phe Glu Phe 435 440 445 Leu Ala Asp Val Pro Glu Lys Leu Ala Ala Ala Val Thr Val Phe Val 450 455 460 Asn Phe Leu Asn Glu Phe Phe Glu Ser Ala Cys Asp Cys Leu Lys Val 465 470 475 480 Gly Gly Lys Thr Phe Asn Lys Val Gly Ser Tyr Val Leu Phe Asp Asn 485 490 495 Ala Leu Val Lys Leu Val Lys Ala Lys Ala Arg Gly Pro Arg Gln Ala 500 505 510 Gly Ile Cys Glu Val Arg Tyr Thr Ser Leu Val Val Gly Ser Thr Thr 515 520 525 Lys Val Val Ser Lys Arg Val Glu Asn Ala Asn Val Asn Leu Val Val 530 535 540 Val Asp Glu Asp Val Thr Leu Asn Thr Thr Gly Arg Thr Val Val Val 545 550 555 560 Asp Gly Leu Ala Phe Phe Glu Ser Asp Gly Phe Tyr Arg His Leu Ala 565 570 575 Asp Ala Asp Val Val Ile Glu His Pro Val Tyr Lys Ser Ala Cys Glu 580 585 590 Leu Lys Pro Val Phe Glu Cys Asp Pro Ile Pro Asp Phe Pro Leu Pro 595 600 605 Val Ala Ala Ser Val Ala Glu Leu Cys Val Gln Thr Asp Leu Leu Leu 610 615 620 Lys Asn Tyr Asn Thr Pro Tyr Lys Thr Tyr Ser Cys Val Val Arg Gly 625 630 635 640 Asp Lys Cys Cys Ile Thr Cys Thr Leu Gln Phe Lys Ala Pro Ser Tyr 645 650 655 Val Glu Asp Ala Val Asn Phe Val Asp Leu Cys Thr Lys Asn Ile Gly 660 665 670 Thr Ala Gly Phe His Glu Phe Tyr Ile Thr Ala His Glu Gln Gln Asp 675 680 685 Leu Gln Gly Phe Leu Thr Thr Cys Cys Thr Met Ser Gly Phe Glu Cys 690 695 700 Phe Met Pro Thr Ile Pro Gln Cys Pro Ala Val Leu Glu Glu Ile Asp 705 710 715 720 Gly Gly Ser Ile Trp Arg Ser Phe Ile Thr Gly Leu Asn Thr Met Trp 725 730 735 Asp Phe Cys Lys Arg Leu Lys Val Ser Phe Gly Leu Asp Gly Ile Val 740 745 750 Val Thr Val Ala Arg Lys Phe Lys Arg Leu Gly Ala Leu Leu Ala Glu 755 760 765 Met Tyr Asn Thr Tyr Leu Ser Thr Val Val Glu Asn Leu Val Leu Ala 770 775 780 Gly Val Ser Phe Lys Tyr Tyr Ala Thr Ser Val Pro Lys Ile Val Leu 785 790 795 800 Gly Gly Cys Phe His Ser Val Lys Ser Val Phe Ala Ser Val Phe Gln 805 810 815 Ile Pro Val Gln Ala Gly Ile Glu Lys Phe Lys Val Phe Leu Asn Cys 820 825 830 Val His Pro Val Val Pro Arg Val Ile Glu Thr Ser Phe Val Glu Leu 835 840 845 Glu Glu Thr Thr Phe Lys Pro Pro Ala Leu Asn Gly Gly Ile Ala Ile 850 855 860 Val Asp Gly Phe Ala Phe Tyr Tyr Asp Gly Thr Leu Tyr Tyr Pro Thr 865 870 875 880 Asp Gly Asn Ser Val Val Pro Ile Cys Phe Lys Lys Lys Gly Gly Gly 885 890 895 Asp Val Lys Phe Ser Asp Glu Val Ser Val Lys Thr Ile Asp Pro Val 900 905 910 Tyr Lys Val Ser Leu Glu Phe Glu Phe Glu Ser Glu Thr Ile Met Ala 915 920 925 Val Leu Asn Lys Ala Val Gly Asn Arg Ile Lys Val Thr Gly Gly Trp 930 935 940 Asp Asp Val Val Glu Tyr Ile Asn Val Ala Ile Glu Val Leu Lys Asp 945 950 955 960 His Val Glu Val Pro Lys Tyr Tyr Ile Tyr Asp Glu Glu Gly Gly Thr 965 970 975 Asp Pro Asn Leu Pro Val Met Val Ser Gln Trp Pro Leu Asn Asp Asp 980 985 990 Thr Ile Ser Gln Asp Leu Leu Asp Val Glu Val Val Thr Asp Ala Pro 995 1000 1005 Ile Asp Ser Glu Gly Asp Glu Val Asp Ser Ser Ala Pro Glu Lys 1010 1015 1020 Val Ala Asp Val Ala Asn Ser Glu Pro Gly Asp Asp Gly Leu Pro 1025 1030 1035 Val Ala Pro Glu Thr Asn Val Glu Ser Glu Val Glu Glu Val Ala 1040 1045 1050 Ala Thr Leu Ser Phe Ile Lys Asp Thr Pro Ser Thr Val Thr Lys 1055 1060 1065 Asp Pro Phe Ala Phe Asp Phe Val Ser Tyr Gly Gly Leu Lys Val 1070 1075 1080 Leu Arg Gln Ser His Asn Asn Cys Trp Val Thr Ser Thr Leu Val 1085 1090 1095 Gln Leu Gln Leu Leu Gly Ile Val Asp Asp Pro Ala Met Glu Leu 1100 1105 1110 Phe Ser Ala Gly Arg Val Gly Pro Met Val Arg Lys Cys Tyr Glu 1115 1120 1125 Ser Gln Lys Ala Ile Leu Gly Ser Leu Gly Asp Val Ser Ala Cys 1130 1135 1140 Leu Glu Ser Leu Thr Lys Asp Leu His Thr Leu Lys Ile Thr Cys 1145 1150 1155 Ser Val Val Cys Gly Cys Gly Thr Gly Glu Arg Ile Tyr Glu Gly 1160 1165 1170 Cys Ala Phe Arg Met Thr Pro Thr Leu Glu Pro Phe Pro Tyr Gly 1175 1180 1185 Ala Cys Ala Gln Cys Ala Gln Val Leu Met His Thr Phe Lys Ser 1190 1195 1200 Ile Val Gly Thr Gly Ile Phe Cys Arg Asp Thr Thr Ala Leu Ser 1205 1210 1215 Leu Asp Ser Leu Val Val Lys Pro Leu Cys Ala Ala Ala Phe Ile 1220 1225 1230 Gly Lys Asp Ser Gly His Tyr Val Thr Asn Phe Tyr Asp Ala Ala 1235 1240 1245 Met Ala Ile Asp Gly Tyr Gly Arg His Gln Ile Lys Tyr Asp Thr 1250 1255 1260 Leu Asn Thr Ile Cys Val Lys Asp Val Asn Trp Thr Ala Pro Leu 1265 1270 1275 Val Pro Ala Val Asp Ser Val Val Glu Pro Val Val Lys Pro Phe 1280 1285 1290 Tyr Ser Tyr Lys Asn Val Asp Phe Tyr Gln Gly Asp Phe Ser Asp 1295 1300 1305 Leu Val Lys Leu Pro Cys Asp Phe Val Val Asn Ala Ala Asn Glu 1310 1315 1320 Lys Leu Ser His Gly Gly Gly Ile Ala Lys Ala Ile Asp Val Tyr 1325 1330 1335 Thr Lys Gly Met Leu Gln Lys Cys Ser Asn Asp Tyr Ile Lys Ala 1340 1345 1350 His Gly Pro Ile Lys Val Gly Arg Gly Val Met Leu Glu Ala Leu 1355 1360 1365 Gly Leu Lys Val Phe Asn Val Val Gly Pro Arg Lys Gly Lys His 1370 1375 1380 Ala Pro Glu Leu Leu Val Lys Ala Tyr Lys Ser Val Phe Ala Asn 1385 1390 1395 Ser Gly Val Ala Leu Thr Pro Leu Ile Ser Val Gly Ile Phe Ser 1400 1405 1410 Val Pro Leu Glu Glu Ser Leu Ser Ala Phe Leu Ala Cys Val Gly 1415 1420 1425 Asp Arg His Cys Lys Cys Phe Cys Tyr Gly Asp Lys Glu Arg Glu 1430 1435 1440 Ala Ile Ile Lys Tyr Met Asp Gly Leu Val Asp Ala Ile Phe Lys 1445 1450 1455 Glu Ala Leu Val Asp Thr Thr Pro Val Gln Glu Asp Val Gln Gln 1460 1465 1470 Val Ser Gln Lys Pro Val Leu Pro Asn Phe Glu Pro Phe Arg Ile 1475 1480 1485 Glu Gly Ala His Ala Phe Tyr Glu Cys Asn Pro Glu Gly Leu Met 1490 1495 1500 Ser Leu Gly Ala Asp Lys Leu Val Leu Phe Thr Asn Ser Asn Leu 1505 1510 1515 Asp Phe Cys Ser Val Gly Lys Cys Leu Asn Asp Val Thr Ser Gly 1520 1525 1530 Ala Leu Leu Glu Ala Ile Asn Val Phe Lys Lys Ser Asn Lys Thr 1535 1540 1545 Val Pro Ala Gly Asn Cys Val Thr Leu Asp Cys Ala Asn Met Ile 1550 1555 1560 Ser Ile Thr Met Val Val Leu Pro Phe Asp Gly Asp Ala Asn Tyr 1565 1570 1575 Asp Lys Asn Tyr Ala Arg Ala Val Val Lys Val Ser Lys Leu Lys 1580 1585 1590 Gly Lys Leu Val Leu Ala Val Asp Asp Ala Thr Leu Tyr Ser Lys 1595 1600 1605 Leu Ser His Leu Ser Val Leu Gly Phe Val Ser Thr Pro Asp Asp 1610 1615 1620 Val Glu Arg Phe Tyr Ala Asn Lys Ser Val Val Ile Lys Val Thr 1625 1630 1635 Glu Asp Thr Arg Ser Val Lys Ala Val Lys Val Glu Ser Thr Ala 1640 1645 1650 Thr Tyr Gly Gln Gln Ile Gly Pro Cys Leu Val Asn Asp Thr Val 1655 1660 1665 Val Thr Asp Asn Lys Pro Val Val Ala Asp Val Val Ala Lys Val 1670 1675 1680 Val Pro Asn Ala Asn Trp Asp Ser His Tyr Gly Phe Asp Lys Ala 1685 1690 1695 Gly Glu Phe His Met Leu Asp His Thr Gly Phe Thr Phe Pro Ser 1700 1705 1710 Glu Val Val Asn Gly Arg Arg Val Ile Lys Thr Thr Asp Asn Asn 1715 1720 1725 Cys Trp Val Asn Val Thr Cys Leu Gln Leu Gln Phe Ala Arg Phe 1730 1735 1740 Arg Phe Lys Ser Ala Gly Leu Gln Ala Met Trp Glu Ser Tyr Cys 1745 1750 1755 Thr Gly Asp Val Ala Met Phe Val His Trp Leu Tyr Trp Leu Thr 1760 1765 1770 Gly Val Asp Lys Gly Gln Pro Ser Asp Ser Glu Asn Ala Leu Asn 1775 1780 1785 Met Leu Ser Lys Tyr Ile Val Pro Ala Gly Ser Val Thr Ile Glu 1790 1795 1800 Arg Val Thr His Asp Gly Cys Cys Cys Ser Lys Arg Val Val Thr 1805 1810 1815 Ala Pro Val Val Asn Ala Ser Val Leu Lys Leu Gly Val Glu Asp 1820 1825 1830 Gly Leu Cys Pro His Gly Leu Asn Tyr Ile Gly Lys Val Val Val 1835 1840 1845 Val Lys Gly Thr Thr Ile Val Val Asn Val Gly Lys Pro Val Val 1850 1855 1860 Ala Pro Ser His Leu Phe Leu Lys Gly Val Ser Tyr Thr Thr Phe 1865 1870 1875 Leu Asp Asn Gly Asn Gly Val Val Gly His Tyr Thr Val Phe Asp 1880 1885 1890 His Gly Thr Gly Met Val His Asp Gly Asp Ala Phe Val Pro Gly 1895 1900 1905 Asp Leu Asn Val Ser Pro Val Thr Asn Val Val Val Ser Glu Gln 1910 1915 1920 Thr Ala Val Val Ile Lys Asp Pro Val Lys Lys Ala Glu Leu Asp 1925 1930 1935 Ala Thr Lys Leu Leu Asp Thr Met Asn Tyr Ala Ser Glu Arg Phe 1940 1945 1950 Phe Ser Phe Gly Asp Phe Met Ser Arg Asn Leu Ile Thr Val Phe 1955 1960 1965 Leu Tyr Ile Leu Ser Ile Leu Gly Leu Cys Phe Arg Ala Phe Arg 1970 1975 1980 Lys Arg Asp Val Lys Val Leu Ala Gly Val Pro Gln Arg Thr Gly 1985 1990 1995 Ile Ile Leu Arg Lys Ser Met Arg Tyr Asn Ala Lys Ala Leu Gly 2000 2005 2010 Val Phe Phe Lys Leu Lys Leu Tyr Trp Phe Lys Val Leu Gly Lys 2015 2020 2025 Phe Ser Leu Gly Ile Tyr Ala Leu Tyr Ala Leu Leu Phe Met Thr 2030 2035 2040 Ile Arg Phe Thr Pro Ile Gly Ser Pro Val Cys Asp Asp Val Val 2045 2050 2055 Ala Gly Tyr Ala Asn Ser Ser Phe Asp Lys Asn Glu Tyr Cys Asn 2060 2065 2070 Ser Val Ile Cys Lys Val Cys Leu Tyr Gly Tyr Gln Glu Leu Ser 2075 2080 2085 Asp Phe Ser His Thr Gln Val Val Trp Gln His Leu Arg Asp Pro 2090 2095 2100 Leu Ile Gly Asn Val Met Pro Phe Phe Tyr Leu Ala Phe Leu Ala 2105 2110 2115 Ile Phe Gly Gly Val Tyr Val Lys Ala Ile Thr Leu Tyr Phe Ile 2120 2125 2130 Phe Gln Tyr Leu Asn Ser Leu Gly Val Phe Leu Gly Leu Gln Gln 2135 2140 2145 Ser Ile Trp Phe Leu Gln Leu Val Pro Phe Asp Val Phe Gly Asp 2150 2155 2160 Glu Ile Val Val Phe Phe Ile Val Thr Arg Val Leu Met Phe Ile 2165 2170 2175 Lys His Val Cys Leu Gly Cys Asp Lys Ala Ser Cys Val Ala Cys 2180 2185 2190 Ser Lys Ser Ala Arg Leu Lys Arg Val Pro Val Gln Thr Ile Phe 2195 2200 2205 Gln Gly Thr Ser Lys Ser Phe Tyr Val His Ala Asn Gly Gly Ser 2210 2215 2220 Lys Phe Cys Lys Lys His Asn Phe Phe Cys Leu Asn Cys Asp Ser 2225 2230 2235 Tyr Gly Pro Gly Cys Thr Phe Ile Asn Asp Val Ile Ala Thr Glu 2240 2245 2250 Val Gly Asn Val Val Lys Leu Asn Val Gln Pro Thr Gly Pro Ala 2255 2260 2265 Thr Ile Leu Ile Asp Lys Val Glu Phe Ser Asn Gly Phe Tyr Tyr 2270 2275 2280 Leu Tyr Ser Gly Asp Thr Phe Trp Lys Tyr Asn Phe Asp Ile Thr 2285 2290 2295 Asp Ser Lys Tyr Thr Cys Lys Glu Ala Leu Lys Asn Cys Ser Ile 2300 2305 2310 Ile Thr Asp Phe Ile Val Phe Asn Asn Asn Gly Ser Asn Val Asn 2315 2320 2325 Gln Val Lys Asn Ala Cys Val Tyr Phe Ser Gln Met Leu Cys Lys 2330 2335 2340 Pro Val Lys Leu Val Asp Ser Ala Leu Leu Ala Ser Leu Ser Val 2345 2350 2355 Asp Phe Gly Ala Ser Leu His Ser Ala Phe Val Ser Val Leu Ser 2360 2365 2370 Asn Ser Phe Gly Lys Asp Leu Ser Ser Cys Asn Asp Met Gln Asp 2375 2380 2385 Cys Lys Ser Thr Leu Gly Phe Asp Asp Val Pro Leu Asp Thr Phe 2390 2395 2400 Asn Ala Ala Val Ala Glu Ala His Arg Tyr Asp Val Leu Leu Thr 2405 2410 2415 Asp Met Ser Phe Asn Asn Phe Thr Thr Ser Tyr Ala Lys Pro Glu 2420 2425 2430 Glu Lys Phe Pro Val His Asp Ile Ala Thr Cys Met Arg Val Gly 2435 2440 2445 Ala Lys Ile Val Asn His Asn Val Leu Val Lys Asp Ser Ile Pro 2450 2455 2460 Val Val Trp Leu Val Arg Asp Phe Ile Ala Leu Ser Glu Glu Thr 2465 2470 2475 Arg Lys Tyr Ile Ile Arg Thr Thr Lys Val Lys Gly Ile Thr Phe 2480 2485 2490 Met Leu Thr Phe Asn Asp Cys Arg Met His Thr Thr Ile Pro Thr 2495 2500 2505 Val Cys Ile Ala Asn Lys Lys Gly Ala Gly Leu Pro Ser Phe Ser 2510 2515 2520 Lys Val Lys Lys Phe Phe Trp Phe Leu Cys Leu Phe Ile Val Ala 2525 2530 2535 Ala Phe Phe Ala Leu Ser Phe Leu Asp Phe Ser Thr Gln Val Ser 2540 2545 2550 Ser Asp Ser Asp Tyr Asp Phe Lys Tyr Ile Glu Ser Gly Gln Leu 2555 2560 2565 Lys Thr Phe Asp Asn Pro Leu Ser Cys Val His Asn Val Phe Ile 2570 2575 2580 Asn Phe Asp Gln Trp His Asp Ala Lys Phe Gly Phe Thr Pro Val 2585 2590 2595 Asn Asn Pro Ser Cys Pro Ile Val Val Gly Val Ser Asp Glu Ala 2600 2605 2610 Arg Thr Val Pro Gly Ile Pro Ala Gly Val Tyr Leu Ala Gly Lys 2615 2620 2625 Thr Leu Val Phe Ala Ile Asn Thr Ile Phe Gly Thr Ser Gly Leu 2630 2635 2640 Cys Phe Asp Ala Ser Gly Val Ala Asp Lys Gly Ala Cys Ile Phe 2645 2650 2655 Asn Ser Ala Cys Thr Thr Leu Ser Gly Leu Gly Gly Thr Ala Val 2660 2665 2670 Tyr Cys Tyr Lys Asn Gly Leu Val Glu Gly Ala Lys Leu Tyr Ser 2675 2680 2685 Glu Leu Ala Pro His Ser Tyr Tyr Lys Met Val Asp Gly Asn Ala 2690 2695 2700 Val Ser Leu Pro Glu Ile Ile Ser Arg Gly Phe Gly Ile Arg Thr 2705 2710 2715 Ile Arg Thr Lys Ala Met Thr Tyr Cys Arg Val Gly Gln Cys Val 2720 2725 2730 Gln Ser Ala Glu Gly Val Cys Phe Gly Ala Asp Arg Phe Phe Val 2735 2740 2745 Tyr Asn Ala Glu Ser Gly Ser Asp Phe Val Cys Gly Thr Gly Leu 2750 2755 2760 Phe Thr Leu Leu Met Asn Val Ile Ser Val Phe Ser Lys Thr Val 2765 2770 2775 Pro Val Thr Val Leu Ser Gly Gln Ile Leu Phe Asn Cys Ile Ile 2780 2785 2790 Ala Phe Val Ala Val Ala Val Cys Phe Leu Phe Thr Lys Phe Lys 2795 2800 2805 Arg Met Phe Gly Asp Met Ser Val Gly Val Phe Thr Val Gly Ala 2810 2815 2820 Cys Thr Leu Leu Asn Asn Val Ser Tyr Ile Val Thr Gln Asn Thr 2825 2830 2835 Leu Gly Met Leu Gly Tyr Ala Thr Leu Tyr Phe Leu Cys Thr Lys 2840 2845 2850 Gly Val Arg Tyr Met Trp Ile Trp His Leu Gly Phe Leu Ile Ser 2855 2860 2865 Tyr Ile Leu Ile Ala Pro Trp Trp Val Leu Met Val Tyr Ala Phe 2870 2875 2880 Ser Ala Ile Phe Glu Phe Met Pro Asn Leu Phe Lys Leu Lys Val 2885 2890 2895 Ser Thr Gln Leu Phe Glu Gly Asp Lys Phe Val Gly Ser Phe Glu 2900 2905 2910 Asn Ala Ala Ala Gly Thr Phe Val Leu Asp Met His Ala Tyr Glu 2915 2920 2925 Arg Leu Ala Asn Ser Ile Ser Thr Glu Lys Leu Arg Gln Tyr Ala 2930 2935 2940 Ser Thr Tyr Asn Lys Tyr Lys Tyr Tyr Ser Gly Ser Ala Ser Glu 2945 2950 2955 Ala Asp Tyr Arg Leu Ala Cys Phe Ala His Leu Ala Lys Ala Met 2960 2965 2970 Met Asp Tyr Ala Ser Asn His Asn Asp Thr Leu Tyr Thr Pro Pro 2975 2980 2985 Thr Val Ser Tyr Asn Ser Thr Leu Gln Ala Gly Leu Arg Lys Met 2990 2995 3000 Ala Gln Pro Ser Gly Val Val Glu Lys Cys Ile Val Arg Val Cys 3005 3010 3015 Tyr Gly Asn Met Ala Leu Asn Gly Leu Trp Leu Gly Asp Ile Val 3020 3025 3030 Met Cys Pro Arg His Val Ile Ala Ser Ser Thr Thr Ser Thr Ile 3035 3040 3045 Asp Tyr Asp Tyr Ala Leu Ser Val Leu Arg Leu His Asn Phe Ser 3050 3055 3060 Ile Ser Ser Gly Asn Val Phe Leu Gly Val Val Ser Ala Thr Met 3065 3070 3075 Arg Gly Ala Leu Leu Gln Ile Lys Val Asn Gln Asn Asn Val His 3080 3085 3090 Thr Pro Lys Tyr Thr Tyr Arg Thr Val Arg Pro Gly Glu Ser Phe 3095 3100 3105 Asn Ile Leu Ala Cys Tyr Asp Gly Ala Ala Ala Gly Val Tyr Gly 3110 3115 3120 Val Asn Met Arg Ser Asn Tyr Thr Ile Arg Gly Ser Phe Ile Asn 3125 3130 3135 Gly Ala Cys Gly Ser Pro Gly Tyr Asn Ile Asn Asn Gly Thr Val 3140 3145 3150 Glu Phe Cys Tyr Leu His Gln Leu Glu Leu Gly Ser Gly Cys His 3155 3160 3165 Val Gly Ser Asp Leu Asp Gly Val Met Tyr Gly Gly Tyr Glu Asp 3170 3175 3180 Gln Pro Thr Leu Gln Val Glu Gly Ala Ser Ser Leu Phe Thr Glu 3185 3190 3195 Asn Val Leu Ala Phe Leu Tyr Ala Ala Leu Ile Asn Gly Ser Thr 3200 3205 3210 Trp Trp Leu Ser Ser Ser Arg Ile Ala Val Asp Arg Phe Asn Glu 3215 3220 3225 Trp Ala Val His Asn Gly Met Thr Thr Val Gly Asn Thr Asp Cys 3230 3235 3240 Phe Ser Ile Leu Ala Ala Lys Thr Gly Val Asp Val Gln Arg Leu 3245 3250 3255 Leu Ala Ser Ile Gln Ser Leu His Lys Asn Phe Gly Gly Lys Gln 3260 3265 3270 Ile Leu Gly His Thr Ser Leu Thr Asp Glu Phe Thr Thr Gly Glu 3275 3280 3285 Val Val Arg Gln Met Tyr Gly Val Asn Leu Gln Gly Gly Tyr Val 3290 3295 3300 Ser Arg Ala Cys Arg Asn Val Leu Leu Val Gly Ser Phe Leu Thr 3305 3310 3315 Phe Phe Trp Ser Glu Leu Val Ser Tyr Thr Lys Phe Phe Trp Val 3320 3325 3330 Asn Pro Gly Tyr Val Thr Pro Met Phe Ala Cys Leu Ser Leu Leu 3335 3340 3345 Ser Ser Leu Leu Met Phe Thr Leu Lys His Lys Thr Leu Phe Phe 3350 3355 3360 Gln Val Phe Leu Ile Pro Ala Leu Ile Val Thr Ser Cys Ile Asn 3365 3370 3375 Leu Ala Phe Asp Val Glu Val Tyr Asn Tyr Leu Ala Glu His Phe 3380 3385 3390 Asp Tyr His Val Ser Leu Met Gly Phe Asn Ala Gln Gly Leu Val 3395 3400 3405 Asn Ile Phe Val Cys Phe Val Val Thr Ile Leu His Gly Thr Tyr 3410 3415 3420 Thr Trp Arg Phe Phe Asn Thr Pro Ala Ser Ser Val Thr Tyr Val 3425 3430 3435 Val Ala Leu Leu Thr Ala Ala Tyr Asn Tyr Phe Tyr Ala Ser Asp 3440 3445 3450 Ile Leu Ser Cys Ala Met Thr Leu Phe Ala Ser Val Thr Gly Asn 3455 3460 3465 Trp Phe Val Gly Ala Val Cys Tyr Lys Val Ala Val Tyr Met Ala 3470 3475 3480 Leu Arg Phe Pro Thr Phe Val Ala Ile Phe Gly Asp Ile Lys Ser 3485 3490 3495 Val Met Phe Cys Tyr Leu Val Leu Gly Tyr Phe Thr Cys Cys Phe 3500 3505 3510 Tyr Gly Ile Leu Tyr Trp Phe Asn Arg Phe Phe Lys Val Ser Val 3515 3520 3525 Gly Val Tyr Asp Tyr Thr Val Ser Ala Ala Glu Phe Lys Tyr Met 3530 3535 3540 Val Ala Asn Gly Leu Arg Ala Pro Thr Gly Thr Leu Asp Ser Leu 3545 3550 3555 Leu Leu Ser Ala Lys Leu Ile Gly Ile Gly Gly Glu Arg Asn Ile 3560 3565 3570 Lys Ile Ser Ser Val Gln Ser Lys Leu Thr Asp Ile Lys Cys Ser 3575 3580 3585 Asn Val Val Leu Leu Gly Cys Leu Ser Ser Met Asn Val Ser Ala 3590 3595 3600 Asn Ser Thr Glu Trp Ala Tyr Cys Val Asp Leu His Asn Lys Ile 3605 3610 3615 Asn Leu Cys Asn Asp Pro Glu Lys Ala Gln Glu Met Leu Leu Ala 3620 3625 3630 Leu Leu Ala Phe Phe Leu Ser Lys Asn Ser Ala Phe Gly Leu Asp 3635 3640 3645 Asp Leu Leu Glu Ser Tyr Phe Asn Asp Asn Ser Met Leu Gln Ser 3650 3655 3660 Val Ala Ser Thr Tyr Val Gly Leu Pro Ser Tyr Val Ile Tyr Glu 3665 3670 3675 Asn Ala Arg Gln Gln Tyr Glu Asp Ala Val Asn Asn Gly Ser Pro 3680 3685 3690 Pro Gln Leu Val Lys Gln Leu Arg His Ala Met Asn Val Ala Lys 3695 3700 3705 Ser Glu Phe Asp Arg Glu Ala Ser Thr Gln Arg Lys Leu Asp Arg 3710 3715 3720 Met Ala Glu Gln Ala Ala Ala Gln Met Tyr Lys Glu Ala Arg Ala 3725 3730 3735 Val Asn Arg Lys Ser Lys Val Val Ser Ala Met His Ser Leu Leu 3740 3745 3750 Phe Gly Met Leu Arg Arg Leu Asp Met Ser Ser Val Asp Thr Ile 3755 3760 3765 Leu Asn Leu Ala Lys Asp Gly Val Val Pro Leu Ser Val Ile Pro 3770 3775 3780 Ala Val Ser Ala Thr Lys Leu Asn Ile Val Thr Ser Asp Ile Asp 3785 3790 3795 Ser Tyr Asn Arg Ile Gln Arg Glu Gly Cys Val His Tyr Ala Gly 3800 3805 3810 Thr Ile Trp Asn Ile Ile Asp Ile Lys Asp Asn Asp Gly Lys Val 3815 3820 3825 Val His Val Lys Glu Val Thr Ala Gln Asn Ala Glu Ser Leu Ser 3830 3835 3840 Trp Pro Leu Val Leu Gly Cys Glu Arg Ile Val Lys Leu Gln Asn 3845 3850 3855 Asn Glu Ile Ile Pro Gly Lys Leu Lys Gln Arg Ser Ile Lys Ala 3860 3865 3870 Glu Gly Asp Gly Ile Val Gly Glu Gly Lys Ala Leu Tyr Asn Asn 3875 3880 3885 Glu Gly Gly Arg Thr Phe Met Tyr Ala Phe Ile Ser Asp Lys Pro 3890 3895 3900 Asp Leu Arg Val Val Lys Trp Glu Phe Asp Gly Gly Cys Asn Thr 3905 3910 3915 Ile Glu Leu Glu Pro Pro Arg Lys Phe Leu Val Asp Ser Pro Asn 3920 3925 3930 Gly Ala Gln Ile Lys Tyr Leu Tyr Phe Val Arg Asn Leu Asn Thr 3935 3940 3945 Leu Arg Arg Gly Ala Val Leu Gly Tyr Ile Gly Ala Thr Val Arg 3950 3955 3960 Leu Gln Ala Gly Lys Gln Thr Glu Gln Ala Ile Asn Ser Ser Leu 3965 3970 3975 Leu Thr Leu Cys Ala Phe Ala Val Asp Pro Ala Lys Thr Tyr Ile 3980 3985 3990 Asp Ala Val Lys Ser Gly His Lys Pro Val Gly Asn Cys Val Lys 3995 4000 4005 Met Leu Ala Asn Gly Ser Gly Asn Gly Gln Ala Val Thr Asn Gly 4010 4015 4020 Val Glu Ala Ser Thr Asn Gln Asp Ser Tyr Gly Gly Ala Ser Val 4025 4030 4035 Cys Leu Tyr Cys Arg Ala His Val Glu His Pro Ser Met Asp Gly 4040 4045 4050 Phe Cys Arg Leu Lys Gly Lys Tyr Val Gln Val Pro Leu Gly Thr 4055 4060 4065 Val Asp Pro Ile Arg Phe Val Leu Glu Asn Asp Val Cys Lys Val 4070 4075 4080 Cys Gly Cys Trp Leu Ser Asn Gly Cys Thr Cys Asp Arg Ser Ile 4085 4090 4095 Met Gln Ser Thr 4100 <210> 18 <211> 4382 <212> PRT <213> human SARS virus <220> <221> MISC_FEATURE <223> ORF 1A <400> 18 Met Glu Ser Leu Val Leu Gly Val Asn Glu Lys Thr His Val Gln Leu 1 5 10 15 Ser Leu Pro Val Leu Gln Val Arg Asp Val Leu Val Arg Gly Phe Gly 20 25 30 Asp Ser Val Glu Glu Ala Leu Ser Glu Ala Arg Glu His Leu Lys Asn 35 40 45 Gly Thr Cys Gly Leu Val Glu Leu Glu Lys Gly Val Leu Pro Gln Leu 50 55 60 Glu Gln Pro Tyr Val Phe Ile Lys Arg Ser Asp Ala Leu Ser Thr Asn 65 70 75 80 His Gly His Lys Val Val Glu Leu Val Ala Glu Met Asp Gly Ile Gln 85 90 95 Tyr Gly Arg Ser Gly Ile Thr Leu Gly Val Leu Val Pro His Val Gly 100 105 110 Glu Thr Pro Ile Ala Tyr Arg Asn Val Leu Leu Arg Lys Asn Gly Asn 115 120 125 Lys Gly Ala Gly Gly His Ser Tyr Gly Ile Asp Leu Lys Ser Tyr Asp 130 135 140 Leu Gly Asp Glu Leu Gly Thr Asp Pro Ile Glu Asp Tyr Glu Gln Asn 145 150 155 160 Trp Asn Thr Lys His Gly Ser Gly Ala Leu Arg Glu Leu Thr Arg Glu 165 170 175 Leu Asn Gly Gly Ala Val Thr Arg Tyr Val Asp Asn Asn Phe Cys Gly 180 185 190 Pro Asp Gly Tyr Pro Leu Asp Cys Ile Lys Asp Phe Leu Ala Arg Ala 195 200 205 Gly Lys Ser Met Cys Thr Leu Ser Glu Gln Leu Asp Tyr Ile Glu Ser 210 215 220 Lys Arg Gly Val Tyr Cys Cys Arg Asp His Glu His Glu Ile Ala Trp 225 230 235 240 Phe Thr Glu Arg Ser Asp Lys Ser Tyr Glu His Gln Thr Pro Phe Glu 245 250 255 Ile Lys Ser Ala Lys Lys Phe Asp Thr Phe Lys Gly Glu Cys Pro Lys 260 265 270 Phe Val Phe Pro Leu Asn Ser Lys Val Lys Val Ile Gln Pro Arg Val 275 280 285 Glu Lys Lys Lys Thr Glu Gly Phe Met Gly Arg Ile Arg Ser Val Tyr 290 295 300 Pro Val Ala Ser Pro Gln Glu Cys Asn Asn Met His Leu Ser Thr Leu 305 310 315 320 Met Lys Cys Asn His Cys Asp Glu Val Ser Trp Gln Thr Cys Asp Phe 325 330 335 Leu Lys Ala Thr Cys Glu His Cys Gly Thr Glu Asn Leu Val Ile Glu 340 345 350 Gly Pro Thr Thr Cys Gly Tyr Leu Pro Thr Asn Ala Val Val Lys Met 355 360 365 Pro Cys Pro Ala Cys Gln Asp Pro Glu Ile Gly Pro Glu His Ser Val 370 375 380 Ala Asp Tyr His Asn His Ser Asn Ile Glu Thr Arg Leu Arg Lys Gly 385 390 395 400 Gly Arg Thr Arg Cys Phe Gly Gly Cys Val Phe Ala Tyr Val Gly Cys 405 410 415 Tyr Asn Lys Arg Ala Tyr Trp Val Pro Arg Ala Ser Ala Asp Ile Gly 420 425 430 Ser Gly His Thr Gly Ile Thr Gly Asp Asn Val Glu Thr Leu Asn Glu 435 440 445 Asp Leu Leu Glu Ile Leu Ser Arg Glu Arg Val Asn Ile Asn Ile Val 450 455 460 Gly Asp Phe His Leu Asn Glu Glu Val Ala Ile Ile Leu Ala Ser Phe 465 470 475 480 Ser Ala Ser Thr Ser Ala Phe Ile Asp Thr Ile Lys Ser Leu Asp Tyr 485 490 495 Lys Ser Phe Lys Thr Ile Val Glu Ser Cys Gly Asn Tyr Lys Val Thr 500 505 510 Lys Gly Lys Pro Val Lys Gly Ala Trp Asn Ile Gly Gln Gln Arg Ser 515 520 525 Val Leu Thr Pro Leu Cys Gly Phe Pro Ser Gln Ala Ala Gly Val Ile 530 535 540 Arg Ser Ile Phe Ala Arg Thr Leu Asp Ala Ala Asn His Ser Ile Pro 545 550 555 560 Asp Leu Gln Arg Ala Ala Val Thr Ile Leu Asp Gly Ile Ser Glu Gln 565 570 575 Ser Leu Arg Leu Val Asp Ala Met Val Tyr Thr Ser Asp Leu Leu Thr 580 585 590 Asn Ser Val Ile Ile Met Ala Tyr Val Thr Gly Gly Leu Val Gln Gln 595 600 605 Thr Ser Gln Trp Leu Ser Asn Leu Leu Gly Thr Thr Val Glu Lys Leu 610 615 620 Arg Pro Ile Phe Glu Trp Ile Glu Ala Lys Leu Ser Ala Gly Val Glu 625 630 635 640 Phe Leu Lys Asp Ala Trp Glu Ile Leu Lys Phe Leu Ile Thr Gly Val 645 650 655 Phe Asp Ile Val Lys Gly Gln Ile Gln Val Ala Ser Asp Asn Ile Lys 660 665 670 Asp Cys Val Lys Cys Phe Ile Asp Val Val Asn Lys Ala Leu Glu Met 675 680 685 Cys Ile Asp Gln Val Thr Ile Ala Gly Ala Lys Leu Arg Ser Leu Asn 690 695 700 Leu Gly Glu Val Phe Ile Ala Gln Ser Lys Gly Leu Tyr Arg Gln Cys 705 710 715 720 Ile Arg Gly Lys Glu Gln Leu Gln Leu Leu Met Pro Leu Lys Ala Pro 725 730 735 Lys Glu Val Thr Phe Leu Glu Gly Asp Ser His Asp Thr Val Leu Thr 740 745 750 Ser Glu Glu Val Val Leu Lys Asn Gly Glu Leu Glu Ala Leu Glu Thr 755 760 765 Pro Val Asp Ser Phe Thr Asn Gly Ala Ile Val Gly Thr Pro Val Cys 770 775 780 Val Asn Gly Leu Met Leu Leu Glu Ile Lys Asp Lys Glu Gln Tyr Cys 785 790 795 800 Ala Leu Ser Pro Gly Leu Leu Ala Thr Asn Asn Val Phe Arg Leu Lys 805 810 815 Gly Gly Ala Pro Ile Lys Gly Val Thr Phe Gly Glu Asp Thr Val Trp 820 825 830 Glu Val Gln Gly Tyr Lys Asn Val Arg Ile Thr Phe Glu Leu Asp Glu 835 840 845 Arg Val Asp Lys Val Leu Asn Glu Lys Cys Ser Val Tyr Thr Val Glu 850 855 860 Ser Gly Thr Glu Val Thr Glu Phe Ala Cys Val Val Ala Glu Ala Val 865 870 875 880 Val Lys Thr Leu Gln Pro Val Ser Asp Leu Leu Thr Asn Met Gly Ile 885 890 895 Asp Leu Asp Glu Trp Ser Val Ala Thr Phe Tyr Leu Phe Asp Asp Ala 900 905 910 Gly Glu Glu Asn Phe Ser Ser Arg Met Tyr Cys Ser Phe Tyr Pro Pro 915 920 925 Asp Glu Glu Glu Glu Asp Asp Ala Glu Cys Glu Glu Glu Glu Ile Asp 930 935 940 Glu Thr Cys Glu His Glu Tyr Gly Thr Glu Asp Asp Tyr Gln Gly Leu 945 950 955 960 Pro Leu Glu Phe Gly Ala Ser Ala Glu Thr Val Arg Val Glu Glu Glu 965 970 975 Glu Glu Glu Asp Trp Leu Asp Asp Thr Thr Glu Gln Ser Glu Ile Glu 980 985 990 Pro Glu Pro Glu Pro Thr Pro Glu Glu Pro Val Asn Gln Phe Thr Gly 995 1000 1005 Tyr Leu Lys Leu Thr Asp Asn Val Ala Ile Lys Cys Val Asp Ile 1010 1015 1020 Val Lys Glu Ala Gln Ser Ala Asn Pro Met Val Ile Val Asn Ala 1025 1030 1035 Ala Asn Ile His Leu Lys His Gly Gly Gly Val Ala Gly Ala Leu 1040 1045 1050 Asn Lys Ala Thr Asn Gly Ala Met Gln Lys Glu Ser Asp Asp Tyr 1055 1060 1065 Ile Lys Leu Asn Gly Pro Leu Thr Val Gly Gly Ser Cys Leu Leu 1070 1075 1080 Ser Gly His Asn Leu Ala Lys Lys Cys Leu His Val Val Gly Pro 1085 1090 1095 Asn Leu Asn Ala Gly Glu Asp Ile Gln Leu Leu Lys Ala Ala Tyr 1100 1105 1110 Glu Asn Phe Asn Ser Gln Asp Ile Leu Leu Ala Pro Leu Leu Ser 1115 1120 1125 Ala Gly Ile Phe Gly Ala Lys Pro Leu Gln Ser Leu Gln Val Cys 1130 1135 1140 Val Gln Thr Val Arg Thr Gln Val Tyr Ile Ala Val Asn Asp Lys 1145 1150 1155 Ala Leu Tyr Glu Gln Val Val Met Asp Tyr Leu Asp Asn Leu Lys 1160 1165 1170 Pro Arg Val Glu Ala Pro Lys Gln Glu Glu Pro Pro Asn Thr Glu 1175 1180 1185 Asp Ser Lys Thr Glu Glu Lys Ser Val Val Gln Lys Pro Val Asp 1190 1195 1200 Val Lys Pro Lys Ile Lys Ala Cys Ile Asp Glu Val Thr Thr Thr 1205 1210 1215 Leu Glu Glu Thr Lys Phe Leu Thr Asn Lys Leu Leu Leu Phe Ala 1220 1225 1230 Asp Ile Asn Gly Lys Leu Tyr His Asp Ser Gln Asn Met Leu Arg 1235 1240 1245 Gly Glu Asp Met Ser Phe Leu Glu Lys Asp Ala Pro Tyr Met Val 1250 1255 1260 Gly Asp Val Ile Thr Ser Gly Asp Ile Thr Cys Val Val Ile Pro 1265 1270 1275 Ser Lys Lys Ala Gly Gly Thr Thr Glu Met Leu Ser Arg Ala Leu 1280 1285 1290 Lys Lys Val Pro Val Asp Glu Tyr Ile Thr Thr Tyr Pro Gly Gln 1295 1300 1305 Gly Cys Ala Gly Tyr Thr Leu Glu Glu Ala Lys Thr Ala Leu Lys 1310 1315 1320 Lys Cys Lys Ser Ala Phe Tyr Val Leu Pro Ser Glu Ala Pro Asn 1325 1330 1335 Ala Lys Glu Glu Ile Leu Gly Thr Val Ser Trp Asn Leu Arg Glu 1340 1345 1350 Met Leu Ala His Ala Glu Glu Thr Arg Lys Leu Met Pro Ile Cys 1355 1360 1365 Met Asp Val Arg Ala Ile Met Ala Thr Ile Gln Arg Lys Tyr Lys 1370 1375 1380 Gly Ile Lys Ile Gln Glu Gly Ile Val Asp Tyr Gly Val Arg Phe 1385 1390 1395 Phe Phe Tyr Thr Ser Lys Glu Pro Val Ala Ser Ile Ile Thr Lys 1400 1405 1410 Leu Asn Ser Leu Asn Glu Pro Leu Val Thr Met Pro Ile Gly Tyr 1415 1420 1425 Val Thr His Gly Phe Asn Leu Glu Glu Ala Ala Arg Cys Met Arg 1430 1435 1440 Ser Leu Lys Ala Pro Ala Val Val Ser Val Ser Ser Pro Asp Ala 1445 1450 1455 Val Thr Thr Tyr Asn Gly Tyr Leu Thr Ser Ser Ser Lys Thr Ser 1460 1465 1470 Glu Glu His Phe Val Glu Thr Val Ser Leu Ala Gly Ser Tyr Arg 1475 1480 1485 Asp Trp Ser Tyr Ser Gly Gln Arg Thr Glu Leu Gly Val Glu Phe 1490 1495 1500 Leu Lys Arg Gly Asp Lys Ile Val Tyr His Thr Leu Glu Ser Pro 1505 1510 1515 Val Glu Phe His Leu Asp Gly Glu Val Leu Ser Leu Asp Lys Leu 1520 1525 1530 Lys Ser Leu Leu Ser Leu Arg Glu Val Lys Thr Ile Lys Val Phe 1535 1540 1545 Thr Thr Val Asp Asn Thr Asn Leu His Thr Gln Leu Val Asp Met 1550 1555 1560 Ser Met Thr Tyr Gly Gln Gln Phe Gly Pro Thr Tyr Leu Asp Gly 1565 1570 1575 Ala Asp Val Thr Lys Ile Lys Pro His Val Asn His Glu Gly Lys 1580 1585 1590 Thr Phe Phe Val Leu Pro Ser Asp Asp Thr Leu Arg Ser Glu Ala 1595 1600 1605 Phe Glu Tyr Tyr His Thr Leu Asp Glu Ser Phe Leu Gly Arg Tyr 1610 1615 1620 Met Ser Ala Leu Asn His Thr Lys Lys Trp Lys Phe Pro Gln Val 1625 1630 1635 Gly Gly Leu Thr Ser Ile Lys Trp Ala Asp Asn Asn Cys Tyr Leu 1640 1645 1650 Ser Ser Val Leu Leu Ala Leu Gln Gln Leu Glu Val Lys Phe Asn 1655 1660 1665 Ala Pro Ala Leu Gln Glu Ala Tyr Tyr Arg Ala Arg Ala Gly Asp 1670 1675 1680 Ala Ala Asn Phe Cys Ala Leu Ile Leu Ala Tyr Ser Asn Lys Thr 1685 1690 1695 Val Gly Glu Leu Gly Asp Val Arg Glu Thr Met Thr His Leu Leu 1700 1705 1710 Gln His Ala Asn Leu Glu Ser Ala Lys Arg Val Leu Asn Val Val 1715 1720 1725 Cys Lys His Cys Gly Gln Lys Thr Thr Thr Leu Thr Gly Val Glu 1730 1735 1740 Ala Val Met Tyr Met Gly Thr Leu Ser Tyr Asp Asn Leu Lys Thr 1745 1750 1755 Gly Val Ser Ile Pro Cys Val Cys Gly Arg Asp Ala Thr Gln Tyr 1760 1765 1770 Leu Val Gln Gln Glu Ser Ser Phe Val Met Met Ser Ala Pro Pro 1775 1780 1785 Ala Glu Tyr Lys Leu Gln Gln Gly Thr Phe Leu Cys Ala Asn Glu 1790 1795 1800 Tyr Thr Gly Asn Tyr Gln Cys Gly His Tyr Thr His Ile Thr Ala 1805 1810 1815 Lys Glu Thr Leu Tyr Arg Ile Asp Gly Ala His Leu Thr Lys Met 1820 1825 1830 Ser Glu Tyr Lys Gly Pro Val Thr Asp Val Phe Tyr Lys Glu Thr 1835 1840 1845 Ser Tyr Thr Thr Thr Ile Lys Pro Val Ser Tyr Lys Leu Asp Gly 1850 1855 1860 Val Thr Tyr Thr Glu Ile Glu Pro Lys Leu Asp Gly Tyr Tyr Lys 1865 1870 1875 Lys Asp Asn Ala Tyr Tyr Thr Glu Gln Pro Ile Asp Leu Val Pro 1880 1885 1890 Thr Gln Pro Leu Pro Asn Ala Ser Phe Asp Asn Phe Lys Leu Thr 1895 1900 1905 Cys Ser Asn Thr Lys Phe Ala Asp Asp Leu Asn Gln Met Thr Gly 1910 1915 1920 Phe Thr Lys Pro Ala Ser Arg Glu Leu Ser Val Thr Phe Phe Pro 1925 1930 1935 Asp Leu Asn Gly Asp Val Val Ala Ile Asp Tyr Arg His Tyr Ser 1940 1945 1950 Ala Ser Phe Lys Lys Gly Ala Lys Leu Leu His Lys Pro Ile Val 1955 1960 1965 Trp His Ile Asn Gln Ala Thr Thr Lys Thr Thr Phe Lys Pro Asn 1970 1975 1980 Thr Trp Cys Leu Arg Cys Leu Trp Ser Thr Lys Pro Val Asp Thr 1985 1990 1995 Ser Asn Ser Phe Glu Val Leu Ala Val Glu Asp Thr Gln Gly Met 2000 2005 2010 Asp Asn Leu Ala Cys Glu Ser Gln Gln Pro Thr Ser Glu Glu Val 2015 2020 2025 Val Glu Asn Pro Thr Ile Gln Lys Glu Val Ile Glu Cys Asp Val 2030 2035 2040 Lys Thr Thr Glu Val Val Gly Asn Val Ile Leu Lys Pro Ser Asp 2045 2050 2055 Glu Gly Val Lys Val Thr Gln Glu Leu Gly His Glu Asp Leu Met 2060 2065 2070 Ala Ala Tyr Val Glu Asn Thr Ser Ile Thr Ile Lys Lys Pro Asn 2075 2080 2085 Glu Leu Ser Leu Ala Leu Gly Leu Lys Thr Ile Ala Thr His Gly 2090 2095 2100 Ile Ala Ala Ile Asn Ser Val Pro Trp Ser Lys Ile Leu Ala Tyr 2105 2110 2115 Val Lys Pro Phe Leu Gly Gln Ala Ala Ile Thr Thr Ser Asn Cys 2120 2125 2130 Ala Lys Arg Leu Ala Gln Arg Val Phe Asn Asn Tyr Met Pro Tyr 2135 2140 2145 Val Phe Thr Leu Leu Phe Gln Leu Cys Thr Phe Thr Lys Ser Thr 2150 2155 2160 Asn Ser Arg Ile Arg Ala Ser Leu Pro Thr Thr Ile Ala Lys Asn 2165 2170 2175 Ser Val Lys Ser Val Ala Lys Leu Cys Leu Asp Ala Gly Ile Asn 2180 2185 2190 Tyr Val Lys Ser Pro Lys Phe Ser Lys Leu Phe Thr Ile Ala Met 2195 2200 2205 Trp Leu Leu Leu Leu Ser Ile Cys Leu Gly Ser Leu Ile Cys Val 2210 2215 2220 Thr Ala Ala Phe Gly Val Leu Leu Ser Asn Phe Gly Ala Pro Ser 2225 2230 2235 Tyr Cys Asn Gly Val Arg Glu Leu Tyr Leu Asn Ser Ser Asn Val 2240 2245 2250 Thr Thr Met Asp Phe Cys Glu Gly Ser Phe Pro Cys Ser Ile Cys 2255 2260 2265 Leu Ser Gly Leu Asp Ser Leu Asp Ser Tyr Pro Ala Leu Glu Thr 2270 2275 2280 Ile Gln Val Thr Ile Ser Ser Tyr Lys Leu Asp Leu Thr Ile Leu 2285 2290 2295 Gly Leu Ala Ala Glu Trp Val Leu Ala Tyr Met Leu Phe Thr Lys 2300 2305 2310 Phe Phe Tyr Leu Leu Gly Leu Ser Ala Ile Met Gln Val Phe Phe 2315 2320 2325 Gly Tyr Phe Ala Ser His Phe Ile Ser Asn Ser Trp Leu Met Trp 2330 2335 2340 Phe Ile Ile Ser Ile Val Gln Met Ala Pro Val Ser Ala Met Val 2345 2350 2355 Arg Met Tyr Ile Phe Phe Ala Ser Phe Tyr Tyr Ile Trp Lys Ser 2360 2365 2370 Tyr Val His Ile Met Asp Gly Cys Thr Ser Ser Thr Cys Met Met 2375 2380 2385 Cys Tyr Lys Arg Asn Arg Ala Thr Arg Val Glu Cys Thr Thr Ile 2390 2395 2400 Val Asn Gly Met Lys Arg Ser Phe Tyr Val Tyr Ala Asn Gly Gly 2405 2410 2415 Arg Gly Phe Cys Lys Thr His Asn Trp Asn Cys Leu Asn Cys Asp 2420 2425 2430 Thr Phe Cys Thr Gly Ser Thr Phe Ile Ser Asp Glu Val Ala Arg 2435 2440 2445 Asp Leu Ser Leu Gln Phe Lys Arg Pro Ile Asn Pro Thr Asp Gln 2450 2455 2460 Ser Ser Tyr Ile Val Asp Ser Val Ala Val Lys Asn Gly Ala Leu 2465 2470 2475 His Leu Tyr Phe Asp Lys Ala Gly Gln Lys Thr Tyr Glu Arg His 2480 2485 2490 Pro Leu Ser His Phe Val Asn Leu Asp Asn Leu Arg Ala Asn Asn 2495 2500 2505 Thr Lys Gly Ser Leu Pro Ile Asn Val Ile Val Phe Asp Gly Lys 2510 2515 2520 Ser Lys Cys Asp Glu Ser Ala Ser Lys Ser Ala Ser Val Tyr Tyr 2525 2530 2535 Ser Gln Leu Met Cys Gln Pro Ile Leu Leu Leu Asp Gln Val Leu 2540 2545 2550 Val Ser Asp Val Gly Asp Ser Thr Glu Val Ser Val Lys Met Phe 2555 2560 2565 Asp Ala Tyr Val Asp Thr Phe Ser Ala Thr Phe Ser Val Pro Met 2570 2575 2580 Glu Lys Leu Lys Ala Leu Val Ala Thr Ala His Ser Glu Leu Ala 2585 2590 2595 Lys Gly Val Ala Leu Asp Gly Val Leu Ser Thr Phe Val Ser Ala 2600 2605 2610 Ala Arg Gln Gly Val Val Asp Thr Asp Val Asp Thr Lys Asp Val 2615 2620 2625 Ile Glu Cys Leu Lys Leu Ser His His Ser Asp Leu Glu Val Thr 2630 2635 2640 Gly Asp Ser Cys Asn Asn Phe Met Leu Thr Tyr Asn Lys Val Glu 2645 2650 2655 Asn Met Thr Pro Arg Asp Leu Gly Ala Cys Ile Asp Cys Asn Ala 2660 2665 2670 Arg His Ile Asn Ala Gln Val Ala Lys Ser His Asn Val Ser Leu 2675 2680 2685 Ile Trp Asn Val Lys Asp Tyr Met Ser Leu Ser Glu Gln Leu Arg 2690 2695 2700 Lys Gln Ile Arg Ser Ala Ala Lys Lys Asn Asn Ile Pro Phe Arg 2705 2710 2715 Leu Thr Cys Ala Thr Thr Arg Gln Val Val Asn Val Ile Thr Thr 2720 2725 2730 Lys Ile Ser Leu Lys Gly Gly Lys Ile Val Ser Thr Cys Phe Lys 2735 2740 2745 Leu Met Leu Lys Ala Thr Leu Leu Cys Val Leu Ala Ala Leu Val 2750 2755 2760 Cys Tyr Ile Val Met Pro Val His Thr Leu Ser Ile His Asp Gly 2765 2770 2775 Tyr Thr Asn Glu Ile Ile Gly Tyr Lys Ala Ile Gln Asp Gly Val 2780 2785 2790 Thr Arg Asp Ile Ile Ser Thr Asp Asp Cys Phe Ala Asn Lys His 2795 2800 2805 Ala Gly Phe Asp Ala Trp Phe Ser Gln Arg Gly Gly Ser Tyr Lys 2810 2815 2820 Asn Asp Lys Ser Cys Pro Val Val Ala Ala Ile Ile Thr Arg Glu 2825 2830 2835 Ile Gly Phe Ile Val Pro Gly Leu Pro Gly Thr Val Leu Arg Ala 2840 2845 2850 Ile Asn Gly Asp Phe Leu His Phe Leu Pro Arg Val Phe Ser Ala 2855 2860 2865 Val Gly Asn Ile Cys Tyr Thr Pro Ser Lys Leu Ile Glu Tyr Ser 2870 2875 2880 Asp Phe Ala Thr Ser Ala Cys Val Leu Ala Ala Glu Cys Thr Ile 2885 2890 2895 Phe Lys Asp Ala Met Gly Lys Pro Val Pro Tyr Cys Tyr Asp Thr 2900 2905 2910 Asn Leu Leu Glu Gly Ser Ile Ser Tyr Ser Glu Leu Arg Pro Asp 2915 2920 2925 Thr Arg Tyr Val Leu Met Asp Gly Ser Ile Ile Gln Phe Pro Asn 2930 2935 2940 Thr Tyr Leu Glu Gly Ser Val Arg Val Val Thr Thr Phe Asp Ala 2945 2950 2955 Glu Tyr Cys Arg His Gly Thr Cys Glu Arg Ser Glu Val Gly Ile 2960 2965 2970 Cys Leu Ser Thr Ser Gly Arg Trp Val Leu Asn Asn Glu His Tyr 2975 2980 2985 Arg Ala Leu Ser Gly Val Phe Cys Gly Val Asp Ala Met Asn Leu 2990 2995 3000 Ile Ala Asn Ile Phe Thr Pro Leu Val Gln Pro Val Gly Ala Leu 3005 3010 3015 Asp Val Ser Ala Ser Val Val Ala Gly Gly Ile Ile Ala Ile Leu 3020 3025 3030 Val Thr Cys Ala Ala Tyr Tyr Phe Met Lys Phe Arg Arg Val Phe 3035 3040 3045 Gly Glu Tyr Asn His Val Val Ala Ala Asn Ala Leu Leu Phe Leu 3050 3055 3060 Met Ser Phe Thr Ile Leu Cys Leu Val Pro Ala Tyr Ser Phe Leu 3065 3070 3075 Pro Gly Val Tyr Ser Val Phe Tyr Leu Tyr Leu Thr Phe Tyr Phe 3080 3085 3090 Thr Asn Asp Val Ser Phe Leu Ala His Leu Gln Trp Phe Ala Met 3095 3100 3105 Phe Ser Pro Ile Val Pro Phe Trp Ile Thr Ala Ile Tyr Val Phe 3110 3115 3120 Cys Ile Ser Leu Lys His Cys His Trp Phe Phe Asn Asn Tyr Leu 3125 3130 3135 Arg Lys Arg Val Met Phe Asn Gly Val Thr Phe Ser Thr Phe Glu 3140 3145 3150 Glu Ala Ala Leu Cys Thr Phe Leu Leu Asn Lys Glu Met Tyr Leu 3155 3160 3165 Lys Leu Arg Ser Glu Thr Leu Leu Pro Leu Thr Gln Tyr Asn Arg 3170 3175 3180 Tyr Leu Ala Leu Tyr Asn Lys Tyr Lys Tyr Phe Ser Gly Ala Leu 3185 3190 3195 Asp Thr Thr Ser Tyr Arg Glu Ala Ala Cys Cys His Leu Ala Lys 3200 3205 3210 Ala Leu Asn Asp Phe Ser Asn Ser Gly Ala Asp Val Leu Tyr Gln 3215 3220 3225 Pro Pro Gln Thr Ser Ile Thr Ser Ala Val Leu Gln Ser Gly Phe 3230 3235 3240 Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys Met Val 3245 3250 3255 Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu Asp 3260 3265 3270 Asp Thr Val Tyr Cys Pro Arg His Val Ile Cys Thr Ala Glu Asp 3275 3280 3285 Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn 3290 3295 3300 His Ser Phe Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile 3305 3310 3315 Gly His Ser Met Gln Asn Cys Leu Leu Arg Leu Lys Val Asp Thr 3320 3325 3330 Ser Asn Pro Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro 3335 3340 3345 Gly Gln Thr Phe Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser 3350 3355 3360 Gly Val Tyr Gln Cys Ala Met Arg Pro Asn His Thr Ile Lys Gly 3365 3370 3375 Ser Phe Leu Asn Gly Ser Cys Gly Ser Val Gly Phe Asn Ile Asp 3380 3385 3390 Tyr Asp Cys Val Ser Phe Cys Tyr Met His His Met Glu Leu Pro 3395 3400 3405 Thr Gly Val His Ala Gly Thr Asp Leu Glu Gly Lys Phe Tyr Gly 3410 3415 3420 Pro Phe Val Asp Arg Gln Thr Ala Gln Ala Ala Gly Thr Asp Thr 3425 3430 3435 Thr Ile Thr Leu Asn Val Leu Ala Trp Leu Tyr Ala Ala Val Ile 3440 3445 3450 Asn Gly Asp Arg Trp Phe Leu Asn Arg Phe Thr Thr Thr Leu Asn 3455 3460 3465 Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu Pro Leu Thr 3470 3475 3480 Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln Thr Gly 3485 3490 3495 Ile Ala Val Leu Asp Met Cys Ala Ala Leu Lys Glu Leu Leu Gln 3500 3505 3510 Asn Gly Met Asn Gly Arg Thr Ile Leu Gly Ser Thr Ile Leu Glu 3515 3520 3525 Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val 3530 3535 3540 Thr Phe Gln Gly Lys Phe Lys Lys Ile Val Lys Gly Thr His His 3545 3550 3555 Trp Met Leu Leu Thr Phe Leu Thr Ser Leu Leu Ile Leu Val Gln 3560 3565 3570 Ser Thr Gln Trp Ser Leu Phe Phe Phe Val Tyr Glu Asn Ala Phe 3575 3580 3585 Leu Pro Phe Thr Leu Gly Ile Met Ala Ile Ala Ala Cys Ala Met 3590 3595 3600 Leu Leu Val Lys His Lys His Ala Phe Leu Cys Leu Phe Leu Leu 3605 3610 3615 Pro Ser Leu Ala Thr Val Ala Tyr Phe Asn Met Val Tyr Met Pro 3620 3625 3630 Ala Ser Trp Val Met Arg Ile Met Thr Trp Leu Glu Leu Ala Asp 3635 3640 3645 Thr Ser Leu Ser Gly Tyr Arg Leu Lys Asp Cys Val Met Tyr Ala 3650 3655 3660 Ser Ala Leu Val Leu Leu Ile Leu Met Thr Ala Arg Thr Val Tyr 3665 3670 3675 Asp Asp Ala Ala Arg Arg Val Trp Thr Leu Met Asn Val Ile Thr 3680 3685 3690 Leu Val Tyr Lys Val Tyr Tyr Gly Asn Ala Leu Asp Gln Ala Ile 3695 3700 3705 Ser Met Trp Ala Leu Val Ile Ser Val Thr Ser Asn Tyr Ser Gly 3710 3715 3720 Val Val Thr Thr Ile Met Phe Leu Ala Arg Ala Ile Val Phe Val 3725 3730 3735 Cys Val Glu Tyr Tyr Pro Leu Leu Phe Ile Thr Gly Asn Thr Leu 3740 3745 3750 Gln Cys Ile Met Leu Val Tyr Cys Phe Leu Gly Tyr Cys Cys Cys 3755 3760 3765 Cys Tyr Phe Gly Leu Phe Cys Leu Leu Asn Arg Tyr Phe Arg Leu 3770 3775 3780 Thr Leu Gly Val Tyr Asp Tyr Leu Val Ser Thr Gln Glu Phe Arg 3785 3790 3795 Tyr Met Asn Ser Gln Gly Leu Leu Pro Pro Lys Ser Ser Ile Asp 3800 3805 3810 Ala Phe Lys Leu Asn Ile Lys Leu Leu Gly Ile Gly Gly Lys Pro 3815 3820 3825 Cys Ile Lys Val Ala Thr Val Gln Ser Lys Met Ser Asp Val Lys 3830 3835 3840 Cys Thr Ser Val Val Leu Leu Ser Val Leu Gln Gln Leu Arg Val 3845 3850 3855 Glu Ser Ser Ser Lys Leu Trp Ala Gln Cys Val Gln Leu His Asn 3860 3865 3870 Asp Ile Leu Leu Ala Lys Asp Thr Thr Glu Ala Phe Glu Lys Met 3875 3880 3885 Val Ser Leu Leu Ser Val Leu Leu Ser Met Gln Gly Ala Val Asp 3890 3895 3900 Ile Asn Arg Leu Cys Glu Glu Met Leu Asp Asn Arg Ala Thr Leu 3905 3910 3915 Gln Ala Ile Ala Ser Glu Phe Ser Ser Leu Pro Ser Tyr Ala Ala 3920 3925 3930 Tyr Ala Thr Ala Gln Glu Ala Tyr Glu Gln Ala Val Ala Asn Gly 3935 3940 3945 Asp Ser Glu Val Val Leu Lys Lys Leu Lys Lys Ser Leu Asn Val 3950 3955 3960 Ala Lys Ser Glu Phe Asp Arg Asp Ala Ala Met Gln Arg Lys Leu 3965 3970 3975 Glu Lys Met Ala Asp Gln Ala Met Thr Gln Met Tyr Lys Gln Ala 3980 3985 3990 Arg Ser Glu Asp Lys Arg Ala Lys Val Thr Ser Ala Met Gln Thr 3995 4000 4005 Met Leu Phe Thr Met Leu Arg Lys Leu Asp Asn Asp Ala Leu Asn 4010 4015 4020 Asn Ile Ile Asn Asn Ala Arg Asp Gly Cys Val Pro Leu Asn Ile 4025 4030 4035 Ile Pro Leu Thr Thr Ala Ala Lys Leu Met Val Val Val Pro Asp 4040 4045 4050 Tyr Gly Thr Tyr Lys Asn Thr Cys Asp Gly Asn Thr Phe Thr Tyr 4055 4060 4065 Ala Ser Ala Leu Trp Glu Ile Gln Gln Val Val Asp Ala Asp Ser 4070 4075 4080 Lys Ile Val Gln Leu Ser Glu Ile Asn Met Asp Asn Ser Pro Asn 4085 4090 4095 Leu Ala Trp Pro Leu Ile Val Thr Ala Leu Arg Ala Asn Ser Ala 4100 4105 4110 Val Lys Leu Gln Asn Asn Glu Leu Ser Pro Val Ala Leu Arg Gln 4115 4120 4125 Met Ser Cys Ala Ala Gly Thr Thr Gln Thr Ala Cys Thr Asp Asp 4130 4135 4140 Asn Ala Leu Ala Tyr Tyr Asn Asn Ser Lys Gly Gly Arg Phe Val 4145 4150 4155 Leu Ala Leu Leu Ser Asp His Gln Asp Leu Lys Trp Ala Arg Phe 4160 4165 4170 Pro Lys Ser Asp Gly Thr Gly Thr Ile Tyr Thr Glu Leu Glu Pro 4175 4180 4185 Pro Cys Arg Phe Val Thr Asp Thr Pro Lys Gly Pro Lys Val Lys 4190 4195 4200 Tyr Leu Tyr Phe Ile Lys Gly Leu Asn Asn Leu Asn Arg Gly Met 4205 4210 4215 Val Leu Gly Ser Leu Ala Ala Thr Val Arg Leu Gln Ala Gly Asn 4220 4225 4230 Ala Thr Glu Val Pro Ala Asn Ser Thr Val Leu Ser Phe Cys Ala 4235 4240 4245 Phe Ala Val Asp Pro Ala Lys Ala Tyr Lys Asp Tyr Leu Ala Ser 4250 4255 4260 Gly Gly Gln Pro Ile Thr Asn Cys Val Lys Met Leu Cys Thr His 4265 4270 4275 Thr Gly Thr Gly Gln Ala Ile Thr Val Thr Pro Glu Ala Asn Met 4280 4285 4290 Asp Gln Glu Ser Phe Gly Gly Ala Ser Cys Cys Leu Tyr Cys Arg 4295 4300 4305 Cys His Ile Asp His Pro Asn Pro Lys Gly Phe Cys Asp Leu Lys 4310 4315 4320 Gly Lys Tyr Val Gln Ile Pro Thr Thr Cys Ala Asn Asp Pro Val 4325 4330 4335 Gly Phe Thr Leu Arg Asn Thr Val Cys Thr Val Cys Gly Met Trp 4340 4345 4350 Lys Gly Tyr Gly Cys Ser Cys Asp Gln Leu Arg Glu Pro Leu Met 4355 4360 4365 Gln Ser Ala Asp Ala Ser Thr Phe Leu Asn Gly Phe Ala Val 4370 4375 4380 <210> 19 <211> 4383 <212> PRT <213> Bovine coronavirus <220> <221> MISC_FEATURE <223> ORF 1A <400> 19 Met Ser Lys Ile Asn Lys Tyr Gly Leu Glu Leu His Trp Ala Pro Glu 1 5 10 15 Phe Pro Trp Met Phe Glu Asp Ala Glu Glu Lys Leu Asp Asn Pro Ser 20 25 30 Ser Ser Glu Val Asp Ile Val Cys Ser Thr Thr Ala Gln Lys Leu Glu 35 40 45 Thr Gly Gly Ile Cys Pro Glu Asn His Val Met Val Asp Cys Arg Arg 50 55 60 Leu Leu Lys Gln Glu Cys Cys Val Gln Ser Ser Leu Ile Arg Glu Ile 65 70 75 80 Val Met Asn Thr Arg Pro Tyr Asp Leu Glu Val Leu Leu Gln Asp Ala 85 90 95 Leu Gln Ser Arg Glu Ala Val Leu Val Thr Pro Pro Leu Gly Met Ser 100 105 110 Leu Glu Ala Cys Tyr Val Arg Gly Cys Asn Pro Asn Gly Trp Thr Met 115 120 125 Gly Leu Phe Arg Arg Arg Ser Val Cys Asn Thr Gly Arg Cys Ala Val 130 135 140 Asn Lys His Val Ala Tyr Gln Leu Tyr Met Ile Asp Pro Ala Gly Val 145 150 155 160 Cys Phe Gly Ala Gly Gln Phe Val Gly Trp Val Ile Pro Leu Ala Phe 165 170 175 Met Pro Val Gln Ser Arg Lys Phe Ile Ala Pro Trp Val Met Tyr Leu 180 185 190 Arg Lys Cys Gly Glu Lys Gly Ala Tyr Ile Lys Asp Tyr Lys Arg Gly 195 200 205 Gly Phe Glu His Val Tyr Asn Phe Lys Val Glu Asp Ala Tyr Asp Leu 210 215 220 Val His Asp Glu Pro Lys Gly Lys Phe Ser Lys Lys Ala Tyr Ala Leu 225 230 235 240 Ile Arg Gly Tyr Arg Gly Val Lys Pro Leu Leu Tyr Val Asp Gln Tyr 245 250 255 Gly Cys Asp Tyr Thr Gly Gly Leu Ala Asp Gly Leu Glu Ala Tyr Ala 260 265 270 Asp Lys Thr Leu Gln Glu Met Lys Ala Leu Phe Pro Ile Trp Ser Gln 275 280 285 Glu Leu Pro Phe Asp Val Thr Val Ala Trp His Val Val Arg Asp Pro 290 295 300 Arg Tyr Val Met Arg Leu Gln Ser Ala Ser Thr Ile Arg Ser Val Ala 305 310 315 320 Tyr Val Ala Asn Pro Thr Glu Asp Leu Cys Asp Gly Ser Val Val Ile 325 330 335 Lys Glu Pro Val His Val Tyr Ala Asp Asp Ser Ile Ile Leu Arg Gln 340 345 350 His Asn Leu Val Asp Ile Met Ser Cys Phe Tyr Met Glu Ala Asp Ala 355 360 365 Val Val Asn Ala Phe Tyr Gly Val Asp Leu Lys Asp Cys Gly Phe Val 370 375 380 Met Gln Phe Gly Tyr Ile Asp Cys Glu Gln Asp Leu Cys Asp Phe Lys 385 390 395 400 Gly Trp Val Pro Gly Asn Met Ile Asp Gly Phe Ala Cys Thr Thr Cys 405 410 415 Gly His Val Tyr Glu Thr Gly Asp Leu Leu Ala Gln Ser Ser Gly Val 420 425 430 Leu Pro Val Asn Pro Val Leu His Thr Lys Ser Ala Ala Gly Tyr Gly 435 440 445 Gly Phe Gly Cys Lys Asp Ser Phe Thr Leu Tyr Gly Gln Thr Val Val 450 455 460 Tyr Phe Gly Gly Cys Val Tyr Trp Ser Pro Ala Arg Asn Ile Trp Ile 465 470 475 480 Pro Ile Leu Lys Ser Ser Val Lys Ser Tyr Asp Gly Leu Val Tyr Thr 485 490 495 Gly Val Val Gly Cys Lys Ala Ile Val Lys Glu Thr Asn Leu Ile Cys 500 505 510 Lys Ala Leu Tyr Leu Asp Tyr Val Gln His Lys Cys Gly Asn Leu His 515 520 525 Gln Arg Glu Leu Leu Gly Val Ser Asp Val Trp His Lys Gln Leu Leu 530 535 540 Leu Asn Arg Gly Val Tyr Lys Pro Leu Leu Glu Asn Ile Asp Tyr Phe 545 550 555 560 Asn Met Arg Arg Ala Lys Phe Ser Leu Glu Thr Phe Thr Val Cys Ala 565 570 575 Asp Gly Phe Met Pro Phe Leu Leu Asp Asp Leu Val Pro Arg Ala Tyr 580 585 590 Tyr Leu Ala Val Ser Gly Gln Ala Phe Cys Asp Tyr Ala Gly Lys Ile 595 600 605 Cys His Ala Val Val Ser Lys Ser Lys Glu Leu Leu Asp Val Ser Val 610 615 620 Asp Ser Leu Gly Ala Ala Ile His Tyr Leu Asn Ser Lys Ile Val Asp 625 630 635 640 Leu Ala Gln His Phe Ser Asp Phe Gly Thr Ser Phe Val Ser Lys Ile 645 650 655 Val His Phe Phe Lys Thr Phe Thr Thr Ser Thr Ala Leu Ala Phe Ala 660 665 670 Trp Val Leu Phe His Val Leu His Gly Ala Tyr Ile Val Val Glu Ser 675 680 685 Asp Ile Tyr Phe Gly Lys Asn Ile Pro Arg Tyr Ala Ser Ala Val Ala 690 695 700 Gln Ala Phe Arg Ser Gly Ala Lys Val Gly Leu Asp Ser Leu Arg Val 705 710 715 720 Thr Phe Ile Asp Gly Leu Ser Cys Phe Lys Ile Gly Arg Arg Arg Ile 725 730 735 Cys Leu Ser Gly Ser Lys Ile Tyr Glu Val Glu Arg Gly Leu Leu His 740 745 750 Ser Ser Gln Leu Pro Leu Asp Val Tyr Asp Leu Thr Met Pro Ser Gln 755 760 765 Val Gln Lys Thr Lys Gln Lys Gly Ile Tyr Leu Lys Gly Ser Gly Ser 770 775 780 Asp Phe Ser Leu Ala Asp Ser Val Val Glu Val Val Thr Thr Ser Leu 785 790 795 800 Thr Pro Cys Gly Tyr Ser Glu Pro Pro Lys Val Ala Asp Lys Ile Cys 805 810 815 Ile Val Asp Asn Val Tyr Met Ala Lys Ala Gly Asp Lys Tyr Tyr Pro 820 825 830 Val Val Val Asp Gly His Val Gly Leu Leu Asp Gln Ala Trp Arg Val 835 840 845 Pro Cys Ala Gly Arg Cys Val Thr Phe Lys Glu Gln Pro Thr Val Asn 850 855 860 Glu Ile Ala Ser Thr Pro Lys Thr Ile Lys Val Phe Tyr Glu Leu Asp 865 870 875 880 Lys Asp Phe Asn Thr Ile Leu Asn Thr Ala Cys Gly Glu Phe Glu Val 885 890 895 Asp Asp Thr Val Asp Met Glu Glu Phe Tyr Ala Val Val Ile Asp Ala 900 905 910 Ile Glu Glu Lys Leu Ser Pro Cys Lys Glu Leu Glu Gly Val Gly Ala 915 920 925 Lys Val Ser Ala Phe Leu Gln Lys Leu Glu Asp Asn Ser Leu Phe Leu 930 935 940 Phe Asp Glu Ala Gly Glu Glu Val Leu Ala Pro Lys Leu Tyr Cys Ala 945 950 955 960 Phe Thr Ala Pro Glu Asp Asp Asp Phe Leu Glu Glu Ser Gly Val Glu 965 970 975 Glu Asp Asp Val Glu Gly Glu Glu Thr Asp Leu Thr Val Thr Ser Ala 980 985 990 Gly Glu Pro Cys Val Ala Ser Glu Gln Glu Glu Ser Ser Glu Ile Leu 995 1000 1005 Glu Asp Thr Leu Asp Asp Gly Pro Cys Val Glu Thr Ser Asp Ser 1010 1015 1020 Gln Val Glu Glu Asp Val Gln Met Ser Asp Phe Gly Asp Leu Glu 1025 1030 1035 Ser Val Ile Gln Asp Tyr Glu Asn Val Cys Phe Glu Phe Tyr Thr 1040 1045 1050 Thr Glu Pro Glu Phe Val Lys Val Leu Asp Leu Tyr Val Pro Lys 1055 1060 1065 Ala Thr Arg Asn Asn Cys Trp Leu Arg Ser Val Leu Ala Val Met 1070 1075 1080 Gln Lys Leu Pro Cys Gln Phe Lys Asp Lys Asn Leu Gln Asp Leu 1085 1090 1095 Trp Val Leu Tyr Lys Gln Gln Tyr Ser Gln Leu Phe Val Asp Thr 1100 1105 1110 Leu Val Asn Lys Ile Pro Ala Asn Ile Val Val Pro Gln Gly Gly 1115 1120 1125 Tyr Val Ala Asp Phe Ala Tyr Trp Phe Leu Thr Leu Cys Asp Trp 1130 1135 1140 Gln Cys Val Ala Tyr Trp Lys Cys Ile Lys Cys Asp Leu Ala Leu 1145 1150 1155 Lys Leu Lys Gly Leu Asp Ala Met Phe Phe Tyr Gly Asp Val Val 1160 1165 1170 Ser His Val Cys Lys Cys Gly Glu Ser Met Val Leu Ile Asp Val 1175 1180 1185 Asp Val Pro Phe Thr Ala His Phe Ala Leu Lys Asp Lys Leu Phe 1190 1195 1200 Cys Ala Phe Ile Thr Lys Arg Ser Val Tyr Lys Ala Ala Cys Val 1205 1210 1215 Val Asp Val Asn Asp Ser His Ser Met Ala Val Val Asp Gly Lys 1220 1225 1230 Gln Ile Asp Asp His Arg Ile Thr Ser Ile Thr Ser Asp Lys Phe 1235 1240 1245 Asp Phe Ile Ile Gly His Gly Thr Ser Phe Ser Met Thr Thr Phe 1250 1255 1260 Glu Ile Ala Gln Leu Tyr Gly Ser Cys Ile Thr Pro Asn Val Cys 1265 1270 1275 Phe Val Lys Gly Asp Ile Ile Lys Val Ser Lys Arg Val Lys Ala 1280 1285 1290 Glu Val Val Val Asn Pro Ala Asn Gly His Met Ala His Gly Gly 1295 1300 1305 Gly Val Ala Lys Ala Ile Ala Val Ala Ala Gly Gln Gln Phe Val 1310 1315 1320 Lys Glu Thr Thr Asp Met Val Lys Ser Lys Gly Val Cys Ala Thr 1325 1330 1335 Gly Asp Cys Tyr Val Ser Thr Gly Gly Lys Leu Cys Lys Thr Val 1340 1345 1350 Leu Asn Val Val Gly Pro Asp Ala Arg Thr Gln Gly Lys Gln Ser 1355 1360 1365 Tyr Ala Leu Leu Glu Arg Val Tyr Lys His Leu Asn Lys Tyr Asp 1370 1375 1380 Cys Val Val Thr Thr Leu Ile Ser Ala Gly Ile Phe Ser Val Pro 1385 1390 1395 Ser Asp Val Ser Leu Thr Tyr Leu Leu Gly Thr Ala Lys Lys Gln 1400 1405 1410 Val Val Leu Val Ser Asn Asn Gln Glu Asp Phe Asp Leu Ile Ser 1415 1420 1425 Lys Cys Gln Ile Thr Ala Val Glu Gly Thr Lys Lys Leu Ala Glu 1430 1435 1440 Arg Leu Ser Phe Asn Val Gly Arg Ser Ile Val Tyr Glu Thr Asp 1445 1450 1455 Ala Asn Lys Leu Ile Leu Ser Asn Asp Val Ala Phe Val Ser Thr 1460 1465 1470 Phe Asn Val Leu Gln Asp Val Leu Ser Leu Arg His Asp Ile Ala 1475 1480 1485 Leu Asp Asp Asp Ala Arg Thr Phe Val Gln Ser Asn Val Asp Val 1490 1495 1500 Val Pro Glu Gly Trp Arg Val Val Asn Lys Phe Tyr Gln Ile Asn 1505 1510 1515 Gly Val Arg Pro Val Lys Tyr Phe Glu Cys Pro Gly Gly Ile Asp 1520 1525 1530 Ile Cys Ser Gln Asp Lys Val Phe Gly Tyr Val Gln Gln Gly Ser 1535 1540 1545 Phe Asn Lys Ala Thr Val Ala Gln Ile Lys Ala Leu Phe Leu Asp 1550 1555 1560 Lys Val Asp Ile Leu Leu Thr Val Asp Gly Val Asn Phe Thr Asn 1565 1570 1575 Arg Phe Val Pro Val Gly Glu Ser Phe Gly Lys Ser Leu Gly Asn 1580 1585 1590 Val Phe Cys Asp Gly Val Asn Val Thr Lys His Lys Cys Asp Ile 1595 1600 1605 Asn Tyr Lys Gly Lys Val Phe Phe Gln Phe Asp Asn Leu Ser Ser 1610 1615 1620 Glu Asp Leu Lys Ala Val Arg Ser Ser Phe Asn Phe Asp Gln Lys 1625 1630 1635 Glu Leu Leu Ala Tyr Tyr Asn Met Leu Val Asn Cys Ser Lys Trp 1640 1645 1650 Gln Val Val Phe Asn Gly Lys Tyr Phe Thr Phe Lys Gln Ala Asn 1655 1660 1665 Asn Asn Cys Phe Val Asn Val Ser Cys Leu Met Leu Gln Ser Leu 1670 1675 1680 Asn Leu Lys Phe Lys Ile Val Gln Trp Gln Glu Ala Trp Leu Glu 1685 1690 1695 Phe Arg Ser Gly Arg Pro Ala Arg Phe Val Ser Leu Val Leu Ala 1700 1705 1710 Lys Gly Gly Phe Lys Phe Gly Asp Pro Ala Asp Ser Arg Asp Phe 1715 1720 1725 Leu Arg Val Val Phe Ser Gln Val Asp Leu Thr Gly Ala Ile Cys 1730 1735 1740 Asp Phe Glu Ile Ala Cys Lys Cys Gly Val Lys Gln Glu Gln Arg 1745 1750 1755 Thr Gly Val Asp Ala Val Met His Phe Gly Thr Leu Ser Arg Glu 1760 1765 1770 Asp Leu Glu Ile Gly Tyr Thr Val Asp Cys Ser Cys Gly Lys Lys 1775 1780 1785 Leu Ile His Cys Val Arg Phe Asp Val Pro Phe Leu Ile Cys Ser 1790 1795 1800 Asn Thr Pro Ala Ser Val Lys Leu Pro Lys Gly Val Gly Ser Ala 1805 1810 1815 Asn Ile Phe Lys Gly Asp Lys Val Gly His Tyr Val His Val Lys 1820 1825 1830 Cys Glu Gln Ser Tyr Gln Leu Tyr Asp Ala Ser Asn Val Lys Lys 1835 1840 1845 Val Thr Asp Val Thr Gly Asn Leu Ser Asp Cys Leu Tyr Leu Lys 1850 1855 1860 Asn Leu Lys Gln Thr Phe Lys Ser Val Leu Thr Thr Tyr Tyr Leu 1865 1870 1875 Asp Asp Val Lys Lys Ile Glu Tyr Lys Pro Asp Leu Ser Gln Tyr 1880 1885 1890 Tyr Cys Asp Gly Gly Lys Tyr Tyr Thr Gln Arg Ile Ile Lys Ala 1895 1900 1905 Gln Phe Lys Thr Phe Glu Lys Val Asp Gly Val Tyr Thr Asn Phe 1910 1915 1920 Lys Leu Ile Gly His Thr Val Cys Asp Ile Leu Asn Ala Lys Leu 1925 1930 1935 Gly Phe Asp Ser Ser Lys Glu Phe Val Glu Tyr Lys Val Thr Glu 1940 1945 1950 Trp Pro Thr Ala Thr Gly Asp Val Val Leu Ala Thr Asp Asp Leu 1955 1960 1965 Tyr Val Lys Arg Tyr Glu Arg Gly Cys Ile Thr Phe Gly Lys Pro 1970 1975 1980 Val Ile Trp Leu Ser His Glu Gln Ala Ser Leu Asn Ser Leu Thr 1985 1990 1995 Tyr Phe Asn Arg Pro Leu Leu Val Asp Glu Asn Lys Phe Asp Val 2000 2005 2010 Leu Lys Val Asp Asp Val Asp Asp Gly Gly Asp Ile Ser Glu Ser 2015 2020 2025 Asp Ala Lys Glu Pro Lys Glu Ile Asn Ile Ile Lys Leu Ser Gly 2030 2035 2040 Val Lys Lys Pro Phe Lys Val Glu Asp Ser Val Ile Val Asn Asp 2045 2050 2055 Asp Thr Ser Glu Ile Lys Tyr Val Lys Ser Leu Ser Ile Val Asp 2060 2065 2070 Val Tyr Asp Met Trp Leu Thr Gly Cys Arg Cys Val Val Arg Thr 2075 2080 2085 Ala Asn Ala Leu Ser Arg Ala Val Asn Val Pro Thr Ile Arg Lys 2090 2095 2100 Phe Ile Lys Phe Gly Met Thr Leu Val Ser Ile Pro Ile Asp Leu 2105 2110 2115 Leu Asn Leu Arg Glu Ile Lys Pro Val Phe Asn Val Val Lys Ala 2120 2125 2130 Val Arg Asn Lys Ile Ser Ala Cys Phe Asn Phe Ile Lys Trp Leu 2135 2140 2145 Phe Val Leu Leu Phe Gly Trp Ile Lys Ile Ser Ala Asp Asn Lys 2150 2155 2160 Val Ile Tyr Thr Thr Glu Val Ala Ser Lys Leu Thr Cys Lys Leu 2165 2170 2175 Val Ala Leu Ala Phe Lys Asn Ala Phe Leu Thr Phe Lys Trp Ser 2180 2185 2190 Val Val Ala Arg Gly Ala Cys Ile Ile Ala Thr Ile Phe Leu Leu 2195 2200 2205 Trp Phe Asn Phe Ile Tyr Ala Asn Val Ile Phe Ser Asp Phe Tyr 2210 2215 2220 Leu Pro Lys Ile Gly Phe Leu Pro Thr Phe Val Gly Lys Ile Val 2225 2230 2235 Gln Trp Ile Lys Asn Thr Phe Ser Leu Val Thr Ile Cys Asp Leu 2240 2245 2250 Tyr Ser Ile Gln Asp Val Gly Phe Lys Asn Gln Tyr Cys Asn Gly 2255 2260 2265 Ser Ile Ala Cys Gln Phe Cys Leu Ala Gly Phe Asp Met Leu Asp 2270 2275 2280 Asn Tyr Lys Ala Ile Asp Val Val Gln Tyr Glu Ala Asp Arg Arg 2285 2290 2295 Ala Phe Val Asp Tyr Thr Gly Val Leu Lys Ile Val Ile Glu Leu 2300 2305 2310 Ile Val Ser Tyr Ala Leu Tyr Thr Ala Trp Phe Tyr Pro Leu Phe 2315 2320 2325 Ala Leu Ile Ser Ile Gln Ile Leu Thr Thr Trp Leu Pro Glu Leu 2330 2335 2340 Leu Met Leu Ser Thr Leu His Trp Ser Val Arg Leu Leu Val Ser 2345 2350 2355 Leu Ala Asn Met Leu Pro Ala His Val Phe Met Arg Phe Tyr Ile 2360 2365 2370 Ile Ile Ala Ser Phe Ile Lys Leu Phe Ser Leu Phe Arg His Val 2375 2380 2385 Ala Tyr Gly Cys Ser Lys Ser Gly Cys Leu Phe Cys Tyr Lys Arg 2390 2395 2400 Asn Arg Ser Leu Arg Val Lys Cys Ser Thr Ile Val Gly Gly Met 2405 2410 2415 Ile Arg Tyr Tyr Asp Val Met Ala Asn Gly Gly Thr Gly Phe Cys 2420 2425 2430 Ser Lys His Gln Trp Asn Cys Ile Asp Cys Asp Ser Tyr Lys Pro 2435 2440 2445 Gly Asn Thr Phe Ile Thr Val Glu Ala Ala Leu Asp Leu Ser Lys 2450 2455 2460 Glu Leu Lys Arg Pro Ile Gln Pro Thr Asp Val Ala Tyr His Thr 2465 2470 2475 Val Thr Asp Val Lys Gln Val Gly Cys Tyr Met Arg Leu Phe Tyr 2480 2485 2490 Asp Arg Asp Gly Gln Arg Thr Tyr Asp Asp Val Asn Ala Ser Leu 2495 2500 2505 Phe Val Asp Tyr Ser Asn Leu Leu His Ser Lys Val Lys Ser Val 2510 2515 2520 Pro Asn Met His Val Val Val Val Glu Asn Asp Ala Asp Lys Ala 2525 2530 2535 Asn Phe Leu Asn Ala Ala Val Phe Tyr Ala Gln Ser Leu Phe Arg 2540 2545 2550 Pro Ile Leu Met Val Asp Lys Ile Leu Ile Thr Thr Ala Asn Thr 2555 2560 2565 Gly Thr Ser Val Thr Glu Thr Met Phe Asp Val Tyr Val Asp Thr 2570 2575 2580 Phe Leu Ser Met Phe Asp Val Asp Lys Lys Ser Leu Asn Ala Leu 2585 2590 2595 Ile Ala Thr Ala His Ser Ser Ile Lys Gln Gly Thr Gln Ile Cys 2600 2605 2610 Lys Val Leu Asp Thr Phe Leu Ser Cys Ala Arg Lys Ser Cys Ser 2615 2620 2625 Ile Asp Ser Asp Val Asp Thr Lys Cys Leu Ala Asp Ser Val Met 2630 2635 2640 Ser Ala Val Ser Ala Gly Leu Glu Leu Thr Asp Glu Ser Cys Asn 2645 2650 2655 Asn Leu Val Pro Thr Tyr Leu Lys Gly Asp Asn Ile Val Ala Ala 2660 2665 2670 Asp Leu Gly Val Leu Ile Gln Asn Ser Ala Lys His Val Gln Gly 2675 2680 2685 Asn Val Ala Lys Ile Ala Gly Val Ser Cys Ile Trp Ser Val Asp 2690 2695 2700 Ala Phe Asn Gln Leu Ser Ser Asp Phe Gln His Lys Leu Lys Lys 2705 2710 2715 Ala Cys Cys Lys Thr Gly Leu Lys Leu Glu Leu Thr Tyr Asn Lys 2720 2725 2730 Gln Met Ala Asn Val Ser Val Leu Thr Thr Pro Phe Ser Leu Lys 2735 2740 2745 Gly Gly Ala Val Phe Ser Tyr Phe Val Tyr Val Cys Phe Val Leu 2750 2755 2760 Ser Leu Val Cys Phe Ile Gly Leu Trp Cys Leu Met Pro Thr Tyr 2765 2770 2775 Thr Val His Lys Ser Asp Phe Gln Leu Pro Val Tyr Ala Ser Tyr 2780 2785 2790 Lys Val Leu Asp Asn Gly Val Ile Arg Asp Val Ser Val Glu Asp 2795 2800 2805 Val Cys Phe Ala Asn Lys Phe Glu Gln Phe Asp Gln Trp Tyr Glu 2810 2815 2820 Ser Thr Phe Gly Leu Ser Tyr Tyr Ser Asn Ser Met Ala Cys Pro 2825 2830 2835 Ile Val Val Ala Val Val Asp Gln Asp Phe Gly Ser Thr Val Phe 2840 2845 2850 Asn Val Pro Thr Lys Val Leu Arg Tyr Gly Tyr His Val Leu His 2855 2860 2865 Phe Ile Thr His Ala Leu Ser Ala Asp Gly Val Gln Cys Tyr Thr 2870 2875 2880 Pro His Ser Gln Ile Ser Tyr Ser Asn Phe Tyr Ala Ser Gly Cys 2885 2890 2895 Val Leu Ser Ser Ala Cys Thr Met Phe Ala Met Ala Asp Gly Ser 2900 2905 2910 Pro Gln Pro Tyr Cys Tyr Thr Asp Gly Leu Met Gln Asn Ala Ser 2915 2920 2925 Leu Tyr Ser Ser Leu Val Pro His Val Arg Tyr Asn Leu Ala Asn 2930 2935 2940 Ala Lys Gly Phe Ile Arg Leu Pro Glu Val Leu Arg Glu Gly Leu 2945 2950 2955 Val Arg Ile Val Arg Thr Arg Ser Met Ser Tyr Cys Arg Val Gly 2960 2965 2970 Leu Cys Glu Glu Ala Asp Glu Gly Ile Cys Phe Asn Phe Asn Gly 2975 2980 2985 Ser Trp Val Leu Asn Asn Asp Tyr Tyr Arg Ser Leu Pro Gly Thr 2990 2995 3000 Phe Cys Gly Arg Asp Val Phe Asp Leu Ile Tyr Gln Leu Phe Lys 3005 3010 3015 Gly Leu Ala Gln Pro Val Asp Phe Leu Ala Leu Thr Ala Ser Ser 3020 3025 3030 Ile Ala Gly Ala Ile Leu Ala Val Ile Val Val Leu Gly Phe Tyr 3035 3040 3045 Tyr Leu Ile Lys Leu Lys Arg Ala Phe Gly Asp Tyr Thr Ser Ile 3050 3055 3060 Val Phe Val Asn Val Ile Val Trp Cys Val Asn Phe Met Met Leu 3065 3070 3075 Phe Val Phe Gln Val Tyr Pro Thr Leu Ser Cys Val Tyr Ala Ile 3080 3085 3090 Cys Tyr Phe Tyr Ala Thr Leu Tyr Phe Pro Ser Glu Ile Ser Val 3095 3100 3105 Ile Met His Leu Gln Trp Leu Val Met Tyr Gly Thr Ile Met Pro 3110 3115 3120 Leu Trp Phe Cys Leu Leu Tyr Ile Ser Val Val Val Ser Asn His 3125 3130 3135 Ala Phe Trp Val Phe Ser Tyr Cys Arg Gln Leu Gly Thr Ser Val 3140 3145 3150 Arg Ser Asp Gly Thr Phe Glu Glu Met Ala Leu Thr Thr Phe Met 3155 3160 3165 Ile Thr Lys Asp Ser Tyr Cys Lys Leu Lys Asn Ser Leu Ser Asp 3170 3175 3180 Val Ala Phe Asn Arg Tyr Leu Ser Leu Tyr Asn Lys Tyr Arg Tyr 3185 3190 3195 Tyr Ser Gly Lys Met Asp Thr Ala Ala Tyr Arg Glu Ala Ala Cys 3200 3205 3210 Ser Gln Leu Ala Lys Ala Met Asp Thr Phe Thr Asn Asn Asn Gly 3215 3220 3225 Ser Asp Val Leu Tyr Gln Pro Pro Thr Ala Ser Val Ser Thr Ser 3230 3235 3240 Phe Leu Gln Ser Gly Ile Val Lys Met Val Asn Pro Thr Ser Lys 3245 3250 3255 Val Glu Pro Cys Ile Val Ser Val Thr Tyr Gly Asn Met Thr Leu 3260 3265 3270 Asn Gly Leu Trp Leu Asp Asp Lys Val Tyr Cys Pro Arg His Val 3275 3280 3285 Ile Cys Ser Ala Ser Asp Met Thr Asn Pro Asp Tyr Thr Asn Leu 3290 3295 3300 Leu Cys Arg Val Thr Ser Ser Asp Phe Thr Val Leu Phe Asp Arg 3305 3310 3315 Leu Ser Leu Thr Val Met Ser Tyr Gln Met Gln Gly Cys Met Leu 3320 3325 3330 Val Leu Thr Val Thr Leu Gln Asn Ser Arg Thr Pro Lys Tyr Thr 3335 3340 3345 Phe Gly Val Val Lys Pro Gly Glu Thr Phe Thr Val Leu Ala Ala 3350 3355 3360 Tyr Asn Gly Lys Pro Gln Gly Ala Phe His Val Thr Met Arg Ser 3365 3370 3375 Ser Tyr Thr Ile Lys Gly Ser Phe Leu Cys Gly Ser Cys Gly Ser 3380 3385 3390 Val Gly Tyr Val Ile Met Gly Asp Cys Val Lys Phe Val Tyr Met 3395 3400 3405 His Gln Leu Glu Leu Ser Thr Gly Cys His Thr Gly Thr Asp Phe 3410 3415 3420 Asn Gly Asp Phe Tyr Gly Pro Tyr Lys Asp Ala Gln Val Val Gln 3425 3430 3435 Leu Pro Val Gln Asp Tyr Ile Gln Ser Val Asn Phe Val Ala Trp 3440 3445 3450 Leu Tyr Ala Ala Ile Leu Asn Asn Cys Asn Trp Phe Val Gln Ser 3455 3460 3465 Asp Lys Cys Ser Val Glu Asp Phe Asn Val Trp Ala Leu Ser Asn 3470 3475 3480 Gly Phe Ser Gln Val Lys Ser Asp Leu Val Ile Asp Ala Leu Ala 3485 3490 3495 Ser Met Thr Gly Val Ser Leu Glu Thr Leu Leu Ala Ala Ile Lys 3500 3505 3510 Arg Leu Lys Asn Gly Phe Gln Gly Arg Gln Ile Met Gly Ser Cys 3515 3520 3525 Ser Phe Glu Asp Glu Leu Thr Pro Ser Asp Val Tyr Gln Gln Leu 3530 3535 3540 Ala Gly Ile Lys Leu Gln Ser Lys Arg Thr Arg Leu Val Lys Gly 3545 3550 3555 Ile Val Cys Trp Ile Met Ala Ser Thr Phe Leu Phe Ser Cys Ile 3560 3565 3570 Ile Thr Ala Phe Val Lys Trp Thr Met Phe Met Tyr Val Thr Thr 3575 3580 3585 Asn Met Leu Ser Ile Thr Phe Cys Ala Leu Cys Val Ile Ser Leu 3590 3595 3600 Ala Met Leu Leu Val Lys His Lys His Leu Tyr Leu Thr Met Tyr 3605 3610 3615 Ile Ile Pro Val Leu Phe Thr Leu Leu Tyr Asn Asn Tyr Leu Val 3620 3625 3630 Val Tyr Lys Gln Thr Phe Arg Gly Tyr Val Tyr Ala Trp Leu Ser 3635 3640 3645 Tyr Tyr Val Pro Ser Val Glu Tyr Thr Tyr Thr Asp Glu Val Ile 3650 3655 3660 Tyr Gly Met Leu Leu Leu Ile Gly Met Val Phe Val Thr Leu Arg 3665 3670 3675 Ser Ile Asn His Asp Leu Phe Ser Phe Ile Met Phe Val Gly Arg 3680 3685 3690 Val Ile Ser Val Val Ser Leu Trp Tyr Met Gly Ser Asn Leu Glu 3695 3700 3705 Glu Glu Ile Leu Leu Met Leu Ala Ser Leu Phe Gly Thr Tyr Thr 3710 3715 3720 Trp Thr Thr Ala Leu Ser Met Ala Ala Ala Lys Val Ile Ala Lys 3725 3730 3735 Trp Val Ala Val Asn Val Leu Tyr Phe Thr Asp Ile Pro Gln Ile 3740 3745 3750 Lys Ile Val Leu Val Cys Tyr Leu Phe Ile Gly Tyr Ile Ile Ser 3755 3760 3765 Cys Tyr Trp Gly Leu Phe Ser Leu Met Asn Ser Leu Phe Arg Met 3770 3775 3780 Pro Leu Gly Val Tyr Asn Tyr Lys Ile Ser Val Gln Glu Leu Arg 3785 3790 3795 Tyr Met Asn Ala Asn Gly Leu Arg Pro Pro Lys Asn Ser Phe Glu 3800 3805 3810 Ala Leu Met Leu Asn Phe Lys Leu Leu Gly Ile Gly Gly Val Pro 3815 3820 3825 Ile Ile Glu Val Ser Gln Phe Gln Ser Lys Leu Thr Asp Val Lys 3830 3835 3840 Cys Ala Asn Gly Gly Leu Leu Asn Cys Leu Gln His Leu His Val 3845 3850 3855 Ala Ser Asn Ser Lys Leu Trp Gln Tyr Cys Ser Thr Leu His Asn 3860 3865 3870 Glu Ile Leu Ala Thr Ser Asp Leu Gly Val Ala Phe Glu Lys Leu 3875 3880 3885 Ala Gln Leu Leu Ile Val Leu Phe Ala Asn Pro Ala Ala Val Asp 3890 3895 3900 Ser Lys Cys Leu Thr Ser Ile Glu Glu Val Cys Asp Asp Tyr Ala 3905 3910 3915 Lys Asp Asn Thr Val Leu Gln Ala Leu Gln Ser Glu Phe Val Asn 3920 3925 3930 Met Ala Ser Phe Val Glu Tyr Glu Val Ala Lys Lys Asn Leu Asp 3935 3940 3945 Glu Ala Cys Ser Ser Gly Ser Ala Asn Gln Gln Gln Leu Lys Gln 3950 3955 3960 Leu Glu Lys Ala Cys Asn Ile Ala Lys Ser Ala Tyr Glu Arg Asp 3965 3970 3975 Arg Ala Val Ala Arg Lys Leu Glu Arg Met Ala Asp Leu Ala Leu 3980 3985 3990 Thr Asn Met Tyr Lys Glu Ala Arg Ile Asn Asp Lys Lys Ser Lys 3995 4000 4005 Val Val Ser Ala Leu Gln Thr Met Leu Phe Ser Met Val Arg Lys 4010 4015 4020 Leu Asp Asn Gln Ala Leu Asn Ser Ile Leu Asp Asn Ala Val Lys 4025 4030 4035 Gly Cys Val Pro Leu Asn Ala Ile Pro Ser Leu Ala Ala Asn Thr 4040 4045 4050 Leu Thr Ile Ile Val Pro Asp Lys Ser Val Tyr Asp Gln Val Val 4055 4060 4065 Asp Asn Val Tyr Val Thr Tyr Ala Gly Asn Val Trp Gln Ile Gln 4070 4075 4080 Thr Ile Gln Asp Ser Asp Gly Thr Asn Lys Gln Leu His Glu Ile 4085 4090 4095 Ser Asp Asp Cys Asn Trp Pro Leu Val Ile Ile Ala Asn Arg His 4100 4105 4110 Asn Glu Val Ser Ala Thr Val Leu Gln Asn Asn Glu Leu Met Pro 4115 4120 4125 Ala Lys Leu Lys Thr Gln Val Val Asn Ser Gly Pro Asp Gln Thr 4130 4135 4140 Cys Asn Thr Pro Thr Gln Cys Tyr Tyr Asn Asn Ser Tyr Asn Gly 4145 4150 4155 Lys Ile Val Tyr Ala Ile Leu Ser Asp Val Asp Gly Leu Lys Tyr 4160 4165 4170 Thr Lys Ile Leu Lys Asp Asp Gly Asn Phe Val Val Leu Glu Leu 4175 4180 4185 Asp Pro Pro Cys Lys Phe Thr Val Gln Asp Val Lys Gly Leu Lys 4190 4195 4200 Ile Lys Tyr Leu Tyr Phe Val Lys Gly Cys Asn Thr Leu Ala Arg 4205 4210 4215 Gly Trp Val Val Gly Thr Ile Ser Ser Thr Val Arg Leu Gln Ala 4220 4225 4230 Gly Thr Ala Thr Glu Tyr Ala Ser Asn Ser Ser Ile Leu Ser Leu 4235 4240 4245 Cys Ala Phe Ser Val Asp Pro Lys Lys Thr Tyr Leu Asp Phe Ile 4250 4255 4260 Gln Gln Gly Gly Thr Pro Ile Ala Asn Cys Val Lys Met Leu Cys 4265 4270 4275 Asp His Ala Gly Thr Gly Met Ala Ile Thr Val Lys Pro Asp Ala 4280 4285 4290 Thr Thr Ser Gln Asp Ser Tyr Gly Gly Ala Ser Val Cys Ile Tyr 4295 4300 4305 Cys Arg Ala Arg Val Glu His Pro Asp Val Asp Gly Leu Cys Lys 4310 4315 4320 Leu Arg Gly Lys Phe Val Gln Val Pro Val Gly Ile Lys Asp Pro 4325 4330 4335 Val Ser Tyr Val Leu Thr His Asp Val Cys Gln Val Cys Gly Phe 4340 4345 4350 Trp Arg Asp Gly Ser Cys Ser Cys Val Ser Thr Asp Thr Thr Val 4355 4360 4365 Gln Ser Lys Asp Thr Asn Phe Leu Asn Gly Phe Gly Val Arg Val 4370 4375 4380 <210> 20 <211> 6685 <212> PRT <213> transmissable gastroenteritus virus <220> <221> MISC_FEATURE <223> ORF 1AB <400> 20 Met Ser Ser Lys Gln Phe Lys Ile Leu Val Asn Glu Asp Tyr Gln Val 1 5 10 15 Asn Val Pro Ser Leu Pro Ile Arg Asp Val Leu Gln Glu Ile Lys Tyr 20 25 30 Cys Tyr Arg Asn Gly Phe Glu Gly Tyr Val Phe Val Pro Glu Tyr Cys 35 40 45 Arg Asp Leu Val Asp Cys Asp Arg Lys Asp His Tyr Val Ile Gly Val 50 55 60 Leu Gly Asn Gly Val Ser Asp Leu Lys Pro Val Leu Leu Thr Glu Pro 65 70 75 80 Ser Val Met Leu Gln Gly Phe Ile Val Arg Ala Asn Cys Asn Gly Val 85 90 95 Leu Glu Asp Phe Asp Leu Lys Ile Ala Arg Thr Gly Arg Gly Ala Ile 100 105 110 Tyr Val Asp Gln Tyr Met Cys Gly Ala Asp Gly Lys Pro Val Ile Glu 115 120 125 Gly Asp Phe Lys Asp Tyr Phe Gly Asp Glu Asp Ile Ile Glu Phe Glu 130 135 140 Gly Glu Glu Tyr His Cys Ala Trp Thr Thr Val Arg Asp Glu Lys Pro 145 150 155 160 Leu Asn Gln Gln Thr Leu Phe Thr Ile Gln Glu Ile Gln Tyr Asn Leu 165 170 175 Asp Ile Pro His Lys Leu Pro Asn Cys Ala Thr Arg His Val Ala Pro 180 185 190 Pro Val Lys Lys Asn Ser Lys Ile Val Leu Ser Glu Asp Tyr Lys Lys 195 200 205 Leu Tyr Asp Ile Phe Gly Ser Pro Phe Met Gly Asn Gly Asp Cys Leu 210 215 220 Ser Lys Cys Phe Asp Thr Leu His Phe Ile Ala Ala Thr Leu Arg Cys 225 230 235 240 Pro Cys Gly Ser Glu Ser Ser Gly Val Gly Asp Trp Thr Gly Phe Lys 245 250 255 Thr Ala Cys Cys Gly Leu Ser Gly Lys Val Lys Gly Val Thr Leu Gly 260 265 270 Asp Ile Lys Pro Gly Asp Ala Val Val Thr Ser Met Ser Ala Gly Lys 275 280 285 Gly Val Lys Phe Phe Ala Asn Cys Val Leu Gln Tyr Ala Gly Asp Val 290 295 300 Glu Gly Val Ser Ile Trp Lys Val Ile Lys Thr Phe Thr Val Asp Glu 305 310 315 320 Thr Val Cys Thr Pro Gly Phe Glu Gly Glu Leu Asn Asp Phe Ile Lys 325 330 335 Pro Glu Ser Lys Ser Leu Val Ala Cys Ser Val Lys Arg Ala Phe Ile 340 345 350 Thr Gly Asp Ile Asp Asp Ala Val His Asp Cys Ile Ile Thr Gly Lys 355 360 365 Leu Asp Leu Ser Thr Asn Leu Phe Gly Asn Val Gly Leu Leu Phe Lys 370 375 380 Lys Thr Pro Trp Phe Val Gln Lys Cys Gly Ala Leu Phe Val Asp Ala 385 390 395 400 Trp Lys Val Val Glu Glu Leu Cys Gly Ser Leu Thr Leu Thr Tyr Lys 405 410 415 Gln Ile Tyr Glu Val Val Ala Ser Leu Cys Thr Ser Ala Phe Thr Ile 420 425 430 Val Asn Tyr Lys Pro Thr Phe Val Val Pro Asp Asn Arg Val Lys Asp 435 440 445 Leu Val Asp Lys Cys Val Lys Val Leu Val Lys Ala Phe Asp Val Phe 450 455 460 Thr Gln Ile Ile Thr Ile Ala Gly Ile Glu Ala Lys Cys Phe Val Leu 465 470 475 480 Gly Ala Lys Tyr Leu Leu Phe Asn Asn Ala Leu Val Lys Leu Val Ser 485 490 495 Val Lys Ile Leu Gly Lys Lys Gln Lys Gly Leu Glu Cys Ala Phe Phe 500 505 510 Ala Thr Ser Leu Val Gly Ala Thr Val Asn Val Thr Pro Lys Arg Thr 515 520 525 Glu Thr Ala Thr Ile Ser Leu Asn Lys Val Asp Asp Val Val Ala Pro 530 535 540 Gly Glu Gly Tyr Ile Val Ile Val Gly Asp Met Ala Phe Tyr Lys Ser 545 550 555 560 Gly Glu Tyr Tyr Phe Met Met Ser Ser Pro Asn Phe Val Leu Thr Asn 565 570 575 Asn Val Phe Lys Ala Val Lys Val Pro Ser Tyr Asp Ile Val Tyr Asp 580 585 590 Val Asp Asn Asp Thr Lys Ser Lys Met Ile Ala Lys Leu Gly Ser Ser 595 600 605 Phe Glu Tyr Asp Gly Asp Ile Asp Ala Ala Ile Val Lys Val Asn Glu 610 615 620 Leu Leu Ile Glu Phe Arg Gln Gln Ser Leu Cys Phe Arg Ala Phe Lys 625 630 635 640 Asp Asp Lys Ser Ile Phe Val Glu Ala Tyr Phe Lys Lys Tyr Lys Met 645 650 655 Pro Ala Cys Leu Ala Lys His Ile Gly Leu Trp Asn Ile Ile Lys Lys 660 665 670 Asp Ser Cys Lys Arg Gly Phe Leu Asn Leu Phe Asn His Leu Asn Glu 675 680 685 Leu Glu Asp Ile Lys Glu Thr Asn Ile Gln Ala Ile Lys Asn Ile Leu 690 695 700 Cys Pro Asp Pro Leu Leu Asp Leu Asp Tyr Gly Ala Ile Trp Tyr Asn 705 710 715 720 Cys Met Pro Gly Cys Ser Asp Pro Ser Val Leu Gly Ser Val Gln Leu 725 730 735 Leu Ile Gly Asn Gly Val Lys Val Val Cys Asp Gly Cys Lys Gly Phe 740 745 750 Ala Asn Gln Leu Ser Lys Gly Tyr Asn Lys Leu Cys Asn Ala Ala Arg 755 760 765 Asn Asp Ile Glu Ile Gly Gly Ile Pro Phe Ser Thr Phe Lys Thr Pro 770 775 780 Thr Asn Thr Phe Ile Glu Met Thr Asp Ala Ile Tyr Ser Val Ile Glu 785 790 795 800 Gln Gly Lys Ala Leu Ser Phe Arg Asp Ala Asp Val Pro Val Val Asp 805 810 815 Asn Gly Thr Ile Ser Thr Ala Asp Trp Ser Glu Pro Ile Leu Leu Glu 820 825 830 Pro Ala Glu Tyr Val Lys Pro Lys Asn Asn Gly Asn Val Ile Val Ile 835 840 845 Ala Gly Tyr Thr Phe Tyr Lys Asp Glu Asp Glu His Phe Tyr Pro Tyr 850 855 860 Gly Phe Gly Lys Ile Val Gln Arg Met Tyr Asn Lys Met Gly Gly Gly 865 870 875 880 Asp Lys Thr Val Ser Phe Ser Glu Glu Val Asp Val Gln Glu Ile Ala 885 890 895 Pro Val Thr Arg Val Lys Leu Glu Phe Glu Phe Asp Asn Glu Ile Val 900 905 910 Thr Gly Val Leu Glu Arg Ala Ile Gly Thr Arg Tyr Lys Phe Thr Gly 915 920 925 Thr Thr Trp Glu Glu Phe Glu Glu Ser Ile Ser Glu Glu Leu Asp Ala 930 935 940 Ile Phe Asp Thr Leu Ala Asn Gln Gly Val Glu Leu Glu Gly Tyr Phe 945 950 955 960 Ile Tyr Asp Thr Cys Gly Gly Phe Asp Ile Lys Asn Pro Asp Gly Ile 965 970 975 Met Ile Ser Gln Tyr Asp Ile Asn Ile Thr Ala Asp Glu Lys Ser Glu 980 985 990 Val Ser Ala Ser Ser Glu Glu Glu Glu Val Glu Ser Val Glu Glu Asp 995 1000 1005 Pro Glu Asn Glu Ile Val Glu Ala Ser Glu Gly Ala Glu Gly Thr 1010 1015 1020 Ser Ser Gln Glu Glu Val Glu Thr Val Glu Val Ala Asp Ile Thr 1025 1030 1035 Ser Thr Glu Glu Asp Val Asp Ile Val Glu Val Ser Ala Lys Asp 1040 1045 1050 Asp Pro Trp Ala Ala Ala Val Asp Val Gln Glu Ala Glu Gln Phe 1055 1060 1065 Asn Pro Ser Leu Pro Pro Phe Lys Thr Thr Asn Leu Asn Gly Lys 1070 1075 1080 Ile Ile Leu Lys Gln Gly Asp Asn Asn Cys Trp Ile Asn Ala Cys 1085 1090 1095 Cys Tyr Gln Leu Gln Ala Phe Asp Phe Phe Asn Asn Glu Ala Trp 1100 1105 1110 Glu Lys Phe Lys Lys Gly Asp Val Met Asp Phe Val Asn Leu Cys 1115 1120 1125 Tyr Ala Ala Thr Thr Leu Ala Arg Gly His Ser Gly Asp Ala Glu 1130 1135 1140 Tyr Leu Leu Glu Leu Met Leu Asn Asp Tyr Ser Thr Ala Lys Ile 1145 1150 1155 Val Leu Ala Ala Lys Cys Gly Cys Gly Glu Lys Glu Ile Val Leu 1160 1165 1170 Glu Arg Ala Val Phe Lys Leu Thr Pro Leu Lys Glu Ser Phe Asn 1175 1180 1185 Tyr Gly Val Cys Gly Asp Cys Met Gln Val Asn Thr Cys Arg Phe 1190 1195 1200 Leu Ser Val Glu Gly Ser Gly Val Phe Val His Asp Ile Leu Ser 1205 1210 1215 Lys Gln Thr Pro Glu Ala Met Phe Val Val Lys Pro Val Met His 1220 1225 1230 Ala Val Tyr Thr Gly Thr Thr Gln Asn Gly His Tyr Met Val Asp 1235 1240 1245 Asp Ile Glu His Gly Tyr Cys Val Asp Gly Met Gly Ile Lys Pro 1250 1255 1260 Leu Lys Lys Arg Cys Tyr Thr Ser Thr Leu Phe Ile Asn Ala Asn 1265 1270 1275 Val Met Thr Arg Ala Glu Lys Pro Lys Gln Glu Phe Lys Val Glu 1280 1285 1290 Lys Val Glu Gln Gln Pro Ile Val Glu Glu Asn Lys Ser Ser Ile 1295 1300 1305 Glu Lys Glu Glu Ile Gln Ser Pro Lys Asn Asp Asp Leu Ile Leu 1310 1315 1320 Pro Phe Tyr Lys Ala Gly Lys Leu Ser Phe Tyr Gln Gly Ala Leu 1325 1330 1335 Asp Val Leu Ile Asn Phe Leu Glu Pro Asp Val Ile Val Asn Ala 1340 1345 1350 Ala Asn Gly Asp Leu Lys His Met Gly Gly Val Ala Arg Ala Ile 1355 1360 1365 Asp Val Phe Thr Gly Gly Lys Leu Thr Glu Arg Ser Lys Asp Tyr 1370 1375 1380 Leu Lys Lys Asn Lys Ser Ile Ala Pro Gly Asn Ala Val Phe Phe 1385 1390 1395 Glu Asn Val Ile Glu His Leu Ser Val Leu Asn Ala Val Gly Pro 1400 1405 1410 Arg Asn Gly Asp Ser Arg Val Glu Ala Lys Leu Cys Asn Val Tyr 1415 1420 1425 Lys Ala Ile Ala Lys Cys Glu Gly Lys Ile Leu Thr Pro Leu Ile 1430 1435 1440 Ser Val Gly Ile Phe Asn Val Arg Leu Glu Thr Ser Leu Gln Cys 1445 1450 1455 Leu Leu Lys Thr Val Asn Asp Arg Gly Leu Asn Val Phe Val Tyr 1460 1465 1470 Thr Asp Gln Glu Arg Gln Thr Ile Glu Asn Phe Phe Ser Cys Ser 1475 1480 1485 Ile Pro Val Asn Val Thr Glu Asp Asn Val Asn His Glu Arg Val 1490 1495 1500 Ser Val Ser Phe Asp Lys Thr Tyr Gly Glu Gln Leu Lys Gly Thr 1505 1510 1515 Val Val Ile Lys Asp Lys Asp Val Thr Asn Gln Leu Pro Ser Ala 1520 1525 1530 Phe Asp Val Gly Gln Lys Val Ile Lys Ala Ile Asp Ile Asp Trp 1535 1540 1545 Gln Ala His Tyr Gly Phe Arg Asp Ala Ala Ala Phe Ser Ala Ser 1550 1555 1560 Ser His Asp Ala Tyr Lys Phe Glu Val Val Thr His Ser Asn Phe 1565 1570 1575 Ile Val His Lys Gln Thr Asp Asn Asn Cys Trp Ile Asn Ala Ile 1580 1585 1590 Cys Leu Ala Leu Gln Arg Leu Lys Pro Gln Trp Lys Phe Pro Gly 1595 1600 1605 Val Arg Gly Leu Trp Asn Glu Phe Leu Glu Arg Lys Thr Gln Gly 1610 1615 1620 Phe Val His Met Leu Tyr His Ile Ser Gly Val Lys Lys Gly Glu 1625 1630 1635 Pro Gly Asp Ala Glu Leu Met Leu His Lys Leu Gly Asp Leu Met 1640 1645 1650 Asp Asn Asp Cys Glu Ile Ile Val Thr His Thr Thr Ala Cys Asp 1655 1660 1665 Lys Cys Ala Lys Val Glu Lys Phe Val Gly Pro Val Val Ala Ala 1670 1675 1680 Pro Leu Ala Ile His Gly Thr Asp Glu Thr Cys Val His Gly Val 1685 1690 1695 Ser Val Asn Val Lys Val Thr Gln Ile Lys Gly Thr Val Ala Ile 1700 1705 1710 Thr Ser Leu Ile Gly Pro Ile Ile Gly Glu Val Leu Glu Ala Thr 1715 1720 1725 Gly Tyr Ile Cys Tyr Ser Gly Ser Asn Arg Asn Gly His Tyr Thr 1730 1735 1740 Tyr Tyr Asp Asn Arg Asn Gly Leu Val Val Asp Ala Glu Lys Ala 1745 1750 1755 Tyr His Phe Asn Arg Asp Leu Leu Gln Val Thr Thr Ala Ile Ala 1760 1765 1770 Ser Asn Phe Val Val Lys Lys Pro Gln Ala Glu Glu Arg Pro Lys 1775 1780 1785 Asn Cys Ala Phe Asn Lys Val Ala Ala Ser Pro Lys Ile Val Gln 1790 1795 1800 Glu Gln Lys Leu Leu Ala Ile Glu Ser Gly Ala Asn Tyr Ala Leu 1805 1810 1815 Thr Glu Phe Gly Arg Tyr Ala Asp Met Phe Phe Met Ala Gly Asp 1820 1825 1830 Lys Ile Leu Arg Leu Leu Leu Glu Val Phe Lys Tyr Leu Leu Val 1835 1840 1845 Leu Phe Met Cys Leu Arg Ser Thr Lys Met Pro Lys Val Lys Val 1850 1855 1860 Lys Pro Pro Leu Ala Phe Lys Asp Phe Gly Ala Lys Val Arg Thr 1865 1870 1875 Leu Asn Tyr Met Arg Gln Leu Asn Lys Pro Ser Val Trp Arg Tyr 1880 1885 1890 Ala Lys Leu Val Leu Leu Leu Ile Ala Ile Tyr Asn Phe Phe Tyr 1895 1900 1905 Leu Phe Val Ser Ile Pro Val Val His Lys Leu Thr Cys Asn Gly 1910 1915 1920 Ala Val Gln Ala Tyr Lys Asn Ser Ser Phe Ile Lys Ser Ala Val 1925 1930 1935 Cys Gly Asn Ser Ile Leu Cys Lys Ala Cys Leu Ala Ser Tyr Asp 1940 1945 1950 Glu Leu Ala Asp Phe Gln His Leu Gln Val Thr Trp Asp Phe Lys 1955 1960 1965 Ser Asp Pro Leu Trp Asn Arg Leu Val Gln Leu Ser Tyr Phe Ala 1970 1975 1980 Phe Leu Ala Val Phe Gly Asn Asn Tyr Val Arg Cys Phe Leu Met 1985 1990 1995 Tyr Phe Val Ser Gln Tyr Leu Asn Leu Trp Leu Ser Tyr Phe Gly 2000 2005 2010 Tyr Val Glu Tyr Ser Trp Phe Leu His Val Val Asn Phe Glu Ser 2015 2020 2025 Ile Ser Ala Glu Phe Val Ile Val Val Ile Val Val Lys Ala Val 2030 2035 2040 Leu Ala Leu Lys His Ile Val Phe Ala Cys Ser Asn Pro Ser Cys 2045 2050 2055 Lys Thr Cys Ser Arg Thr Ala Arg Gln Thr Arg Ile Pro Ile Gln 2060 2065 2070 Val Val Val Asn Gly Ser Met Lys Thr Val Tyr Val His Ala Asn 2075 2080 2085 Gly Thr Gly Lys Phe Cys Lys Lys His Asn Phe Tyr Cys Lys Asn 2090 2095 2100 Cys Asp Ser Tyr Gly Phe Glu Asn Thr Phe Ile Cys Asp Glu Ile 2105 2110 2115 Val Arg Asp Leu Ser Asn Ser Val Lys Gln Thr Val Tyr Ala Thr 2120 2125 2130 Asp Arg Ser His Gln Glu Val Thr Lys Val Glu Cys Ser Asp Gly 2135 2140 2145 Phe Tyr Arg Phe Tyr Val Gly Asp Glu Phe Thr Ser Tyr Asp Tyr 2150 2155 2160 Asp Val Lys His Lys Lys Tyr Ser Ser Gln Glu Val Leu Lys Ser 2165 2170 2175 Met Leu Leu Leu Asp Asp Phe Ile Val Tyr Ser Pro Ser Gly Ser 2180 2185 2190 Ala Leu Ala Asn Val Arg Asn Ala Cys Val Tyr Phe Ser Gln Leu 2195 2200 2205 Ile Gly Lys Pro Ile Lys Ile Val Asn Ser Asp Leu Leu Glu Asp 2210 2215 2220 Leu Ser Val Asp Phe Lys Gly Ala Leu Phe Asn Ala Lys Lys Asn 2225 2230 2235 Val Ile Lys Asn Ser Phe Asn Val Asp Val Ser Glu Cys Lys Asn 2240 2245 2250 Leu Asp Glu Cys Tyr Arg Ala Cys Asn Leu Asn Val Ser Phe Ser 2255 2260 2265 Thr Phe Glu Met Ala Val Asn Asn Ala His Arg Phe Gly Ile Leu 2270 2275 2280 Ile Thr Asp Arg Ser Phe Asn Asn Phe Trp Pro Ser Lys Val Lys 2285 2290 2295 Pro Gly Ser Ser Gly Val Ser Ala Met Asp Ile Gly Lys Cys Met 2300 2305 2310 Thr Ser Asp Ala Lys Ile Val Asn Ala Lys Val Leu Thr Gln Arg 2315 2320 2325 Gly Lys Ser Val Val Trp Leu Ser Gln Asp Phe Ala Ala Leu Ser 2330 2335 2340 Ser Thr Ala Gln Lys Val Leu Val Lys Thr Phe Val Glu Glu Gly 2345 2350 2355 Val Asn Phe Ser Leu Thr Phe Asn Ala Val Gly Ser Asp Asp Asp 2360 2365 2370 Leu Pro Tyr Glu Arg Phe Thr Glu Ser Val Ser Pro Lys Ser Gly 2375 2380 2385 Ser Gly Phe Phe Asp Val Ile Thr Gln Leu Lys Gln Ile Val Ile 2390 2395 2400 Leu Val Phe Val Phe Ile Phe Ile Cys Gly Leu Cys Ser Val Tyr 2405 2410 2415 Ser Val Ala Thr Gln Ser Tyr Ile Glu Ser Ala Glu Gly Tyr Asp 2420 2425 2430 Tyr Met Val Ile Lys Asn Gly Ile Val Gln Pro Phe Asp Asp Thr 2435 2440 2445 Ile Ser Cys Val His Asn Thr Tyr Lys Gly Phe Gly Asp Trp Phe 2450 2455 2460 Lys Ala Lys Tyr Gly Phe Ile Pro Thr Phe Gly Lys Ser Cys Pro 2465 2470 2475 Ile Val Val Gly Thr Val Phe Asp Leu Glu Asn Met Arg Pro Ile 2480 2485 2490 Pro Asp Val Pro Ala Tyr Val Ser Ile Val Gly Arg Ser Leu Val 2495 2500 2505 Phe Ala Ile Asn Ala Ala Phe Gly Val Thr Asn Met Cys Tyr Asp 2510 2515 2520 His Thr Gly Asn Ala Val Ser Lys Asp Ser Tyr Phe Asp Thr Cys 2525 2530 2535 Val Phe Asn Thr Ala Cys Thr Thr Leu Thr Gly Leu Gly Gly Thr 2540 2545 2550 Ile Val Tyr Cys Ala Lys Gln Gly Leu Val Glu Gly Ala Lys Leu 2555 2560 2565 Tyr Ser Asp Leu Met Pro Asp Tyr Tyr Tyr Glu His Ala Ser Gly 2570 2575 2580 Asn Met Val Lys Leu Pro Ala Ile Ile Arg Gly Leu Gly Leu Arg 2585 2590 2595 Phe Val Lys Thr Gln Ala Thr Thr Tyr Cys Arg Val Gly Glu Cys 2600 2605 2610 Ile Asp Ser Lys Ala Gly Phe Cys Phe Gly Gly Asp Asn Trp Phe 2615 2620 2625 Val Tyr Asp Asn Glu Phe Gly Asn Gly Tyr Ile Cys Gly Asn Ser 2630 2635 2640 Val Leu Gly Phe Phe Lys Asn Val Phe Lys Leu Phe Asn Ser Asn 2645 2650 2655 Met Ser Val Val Ala Thr Ser Gly Ala Met Leu Val Asn Ile Ile 2660 2665 2670 Ile Ala Cys Leu Ala Ile Ala Met Cys Tyr Gly Val Leu Lys Phe 2675 2680 2685 Lys Lys Ile Phe Gly Asp Cys Thr Phe Leu Ile Val Met Ile Ile 2690 2695 2700 Val Thr Leu Val Val Asn Asn Val Ser Tyr Phe Val Thr Gln Asn 2705 2710 2715 Thr Phe Phe Met Ile Ile Tyr Ala Ile Val Tyr Tyr Phe Ile Thr 2720 2725 2730 Arg Lys Leu Ala Tyr Pro Gly Ile Leu Asp Ala Gly Phe Ile Ile 2735 2740 2745 Ala Tyr Ile Asn Met Ala Pro Trp Tyr Val Ile Thr Ala Tyr Ile 2750 2755 2760 Leu Val Phe Leu Tyr Asp Ser Leu Pro Ser Leu Phe Lys Leu Lys 2765 2770 2775 Val Ser Thr Asn Leu Phe Glu Gly Asp Lys Phe Val Gly Asn Phe 2780 2785 2790 Glu Ser Ala Ala Met Gly Thr Phe Val Ile Asp Met Arg Ser Tyr 2795 2800 2805 Glu Thr Ile Val Asn Ser Thr Ser Ile Ala Arg Ile Lys Ser Tyr 2810 2815 2820 Ala Asn Ser Phe Asn Lys Tyr Lys Tyr Tyr Thr Gly Ser Met Gly 2825 2830 2835 Glu Ala Asp Tyr Arg Met Ala Cys Tyr Ala His Leu Gly Lys Ala 2840 2845 2850 Leu Met Asp Tyr Ser Val Asn Arg Thr Asp Met Leu Tyr Thr Pro 2855 2860 2865 Pro Thr Val Ser Val Asn Ser Thr Leu Gln Ser Gly Leu Arg Lys 2870 2875 2880 Met Ala Gln Pro Ser Gly Leu Val Glu Pro Cys Ile Val Arg Val 2885 2890 2895 Ser Tyr Gly Asn Asn Val Leu Asn Gly Leu Trp Leu Gly Asp Glu 2900 2905 2910 Val Ile Cys Pro Arg His Val Ile Ala Ser Asp Thr Thr Arg Val 2915 2920 2925 Ile Asn Tyr Glu Asn Glu Met Ser Ser Val Arg Leu His Asn Phe 2930 2935 2940 Ser Val Ser Lys Asn Asn Val Phe Leu Gly Val Val Ser Ala Arg 2945 2950 2955 Tyr Lys Gly Val Asn Leu Val Leu Lys Val Asn Gln Val Asn Pro 2960 2965 2970 Asn Thr Pro Glu His Lys Phe Lys Ser Ile Lys Ala Gly Glu Ser 2975 2980 2985 Phe Asn Ile Leu Ala Cys Tyr Glu Gly Cys Pro Gly Ser Val Tyr 2990 2995 3000 Gly Val Asn Met Arg Ser Gln Gly Thr Ile Lys Gly Ser Phe Ile 3005 3010 3015 Ala Gly Thr Cys Gly Ser Val Gly Tyr Val Leu Glu Asn Gly Ile 3020 3025 3030 Leu Tyr Phe Val Tyr Met His His Leu Glu Leu Gly Asn Gly Ser 3035 3040 3045 His Val Gly Ser Asn Phe Glu Gly Glu Met Tyr Gly Gly Tyr Glu 3050 3055 3060 Asp Gln Pro Ser Met Gln Leu Glu Gly Thr Asn Val Met Ser Ser 3065 3070 3075 Asp Asn Val Val Ala Phe Leu Tyr Ala Ala Leu Ile Asn Gly Glu 3080 3085 3090 Arg Trp Phe Val Thr Asn Thr Ser Met Ser Leu Glu Ser Tyr Asn 3095 3100 3105 Thr Trp Ala Lys Thr Asn Ser Phe Thr Glu Leu Ser Ser Thr Asp 3110 3115 3120 Ala Phe Ser Met Leu Ala Ala Lys Thr Gly Gln Ser Val Glu Lys 3125 3130 3135 Leu Leu Asp Ser Ile Val Arg Leu Asn Lys Gly Phe Gly Gly Arg 3140 3145 3150 Thr Ile Leu Ser Tyr Gly Ser Leu Cys Asp Glu Phe Thr Pro Thr 3155 3160 3165 Glu Val Ile Arg Gln Met Tyr Gly Val Asn Leu Gln Ala Gly Lys 3170 3175 3180 Val Lys Ser Phe Phe Tyr Pro Ile Met Thr Ala Met Thr Ile Leu 3185 3190 3195 Phe Ala Phe Trp Leu Glu Phe Phe Met Tyr Thr Pro Phe Thr Trp 3200 3205 3210 Ile Asn Pro Thr Phe Val Ser Ile Val Leu Ala Val Thr Thr Leu 3215 3220 3225 Ile Ser Thr Val Phe Val Ser Gly Ile Lys His Lys Met Leu Phe 3230 3235 3240 Phe Met Ser Phe Val Leu Pro Ser Val Ile Leu Val Thr Ala His 3245 3250 3255 Asn Leu Phe Trp Asp Phe Ser Tyr Tyr Glu Ser Leu Gln Ser Ile 3260 3265 3270 Val Glu Asn Thr Asn Thr Met Phe Leu Pro Val Asp Met Gln Gly 3275 3280 3285 Val Met Leu Thr Val Phe Cys Phe Ile Val Phe Val Thr Tyr Ser 3290 3295 3300 Val Arg Phe Phe Thr Cys Lys Gln Ser Trp Phe Ser Leu Ala Val 3305 3310 3315 Thr Thr Ile Leu Val Ile Phe Asn Met Val Lys Ile Phe Gly Thr 3320 3325 3330 Ser Asp Glu Pro Trp Thr Glu Asn Gln Ile Ala Phe Cys Phe Val 3335 3340 3345 Asn Met Leu Thr Met Ile Val Ser Leu Thr Thr Lys Asp Trp Met 3350 3355 3360 Val Val Ile Ala Ser Tyr Arg Ile Ala Tyr Tyr Ile Val Val Cys 3365 3370 3375 Val Met Pro Ser Ala Phe Val Ser Asp Phe Gly Phe Met Lys Cys 3380 3385 3390 Ile Ser Ile Val Tyr Met Ala Cys Gly Tyr Leu Phe Cys Cys Tyr 3395 3400 3405 Tyr Gly Ile Leu Tyr Trp Val Asn Arg Phe Thr Cys Met Thr Cys 3410 3415 3420 Gly Val Tyr Gln Phe Thr Val Ser Ala Ala Glu Leu Lys Tyr Met 3425 3430 3435 Thr Ala Asn Asn Leu Ser Ala Pro Lys Asn Ala Tyr Asp Ala Met 3440 3445 3450 Ile Leu Ser Ala Lys Leu Ile Gly Val Gly Gly Lys Arg Asn Ile 3455 3460 3465 Lys Ile Ser Thr Val Gln Ser Lys Leu Thr Glu Met Lys Cys Thr 3470 3475 3480 Asn Val Val Leu Leu Gly Leu Leu Ser Lys Met His Val Glu Ser 3485 3490 3495 Asn Ser Lys Glu Trp Asn Tyr Cys Val Gly Leu His Asn Glu Ile 3500 3505 3510 Asn Leu Cys Asp Asp Pro Glu Ile Val Leu Glu Lys Leu Leu Ala 3515 3520 3525 Leu Ile Ala Phe Phe Leu Ser Lys His Asn Thr Cys Asp Leu Ser 3530 3535 3540 Glu Leu Ile Glu Ser Tyr Phe Glu Asn Thr Thr Ile Leu Gln Ser 3545 3550 3555 Val Ala Ser Ala Tyr Ala Ala Leu Pro Ser Trp Ile Ala Leu Glu 3560 3565 3570 Lys Ala Arg Ala Asp Leu Glu Glu Ala Lys Lys Asn Asp Val Ser 3575 3580 3585 Pro Gln Ile Leu Lys Gln Leu Thr Lys Ala Phe Asn Ile Ala Lys 3590 3595 3600 Ser Asp Phe Glu Arg Glu Ala Ser Val Gln Lys Lys Leu Asp Lys 3605 3610 3615 Met Ala Glu Gln Ala Ala Ala Ser Met Tyr Lys Glu Ala Arg Ala 3620 3625 3630 Val Asp Arg Lys Ser Lys Ile Val Ser Ala Met His Ser Leu Leu 3635 3640 3645 Phe Gly Met Leu Lys Lys Leu Asp Met Ser Ser Val Asn Thr Ile 3650 3655 3660 Ile Asp Gln Ala Arg Asn Gly Val Leu Pro Leu Ser Ile Ile Pro 3665 3670 3675 Ala Ala Ser Ala Thr Arg Leu Val Val Ile Thr Pro Ser Leu Glu 3680 3685 3690 Val Phe Ser Lys Ile Arg Gln Glu Asn Asn Val His Tyr Ala Gly 3695 3700 3705 Ala Ile Trp Thr Ile Val Glu Val Lys Asp Ala Asn Gly Ser His 3710 3715 3720 Val His Leu Lys Glu Val Thr Ala Ala Asn Glu Leu Asn Leu Thr 3725 3730 3735 Trp Pro Leu Ser Ile Thr Cys Glu Arg Thr Thr Lys Leu Gln Asn 3740 3745 3750 Asn Glu Ile Met Pro Gly Lys Leu Lys Glu Arg Ala Val Arg Ala 3755 3760 3765 Ser Ala Thr Leu Asp Gly Glu Ala Phe Gly Ser Gly Lys Ala Leu 3770 3775 3780 Met Ala Ser Glu Ser Gly Lys Ser Phe Met Tyr Ala Phe Ile Ala 3785 3790 3795 Ser Asp Asn Asn Leu Lys Tyr Val Lys Trp Glu Ser Asn Asn Asp 3800 3805 3810 Ile Ile Pro Ile Glu Leu Glu Ala Pro Leu Arg Phe Tyr Val Asp 3815 3820 3825 Gly Ala Asn Gly Pro Glu Val Lys Tyr Leu Tyr Phe Val Lys Asn 3830 3835 3840 Leu Asn Thr Leu Arg Arg Gly Ala Val Leu Gly Tyr Ile Gly Ala 3845 3850 3855 Thr Val Arg Leu Gln Ala Gly Lys Pro Thr Glu His Pro Ser Asn 3860 3865 3870 Ser Ser Leu Leu Thr Leu Cys Ala Phe Ser Pro Asp Pro Ala Lys 3875 3880 3885 Ala Tyr Val Asp Ala Val Lys Arg Gly Met Gln Pro Val Asn Asn 3890 3895 3900 Cys Val Lys Met Leu Ser Asn Gly Ala Gly Asn Gly Met Ala Val 3905 3910 3915 Thr Asn Gly Val Glu Ala Asn Thr Gln Gln Asp Ser Tyr Gly Gly 3920 3925 3930 Ala Ser Val Cys Ile Tyr Cys Arg Cys His Val Glu His Pro Ala 3935 3940 3945 Ile Asp Gly Leu Cys Arg Tyr Lys Gly Lys Phe Val Gln Ile Pro 3950 3955 3960 Thr Gly Thr Gln Asp Pro Ile Arg Phe Cys Ile Glu Asn Glu Val 3965 3970 3975 Cys Val Val Cys Gly Cys Trp Leu Asn Asn Gly Cys Met Cys Asp 3980 3985 3990 Arg Thr Ser Met Gln Ser Phe Thr Val Asp Gln Ser Tyr Leu Phe 3995 4000 4005 Lys Arg Val Arg Gly Ser Ser Ala Ala Arg Leu Glu Pro Cys Asn 4010 4015 4020 Gly Thr Asp Pro Asp His Val Ser Arg Ala Phe Asp Ile Tyr Asn 4025 4030 4035 Lys Asp Val Ala Cys Ile Gly Lys Phe Leu Lys Thr Asn Cys Ser 4040 4045 4050 Arg Phe Arg Asn Leu Asp Lys His Asp Ala Tyr Tyr Ile Val Lys 4055 4060 4065 Arg Cys Thr Lys Thr Val Met Asp His Glu Gln Val Cys Tyr Asn 4070 4075 4080 Asp Leu Lys Asp Ser Gly Ala Val Ala Glu His Asp Phe Phe Thr 4085 4090 4095 Tyr Lys Glu Gly Arg Cys Glu Phe Gly Asn Val Ala Arg Arg Asn 4100 4105 4110 Leu Thr Lys Tyr Thr Met Met Asp Leu Cys Tyr Ala Ile Arg Asn 4115 4120 4125 Phe Asp Glu Lys Asn Cys Glu Val Leu Lys Glu Ile Leu Val Thr 4130 4135 4140 Val Gly Ala Cys Thr Glu Glu Phe Phe Glu Asn Lys Asp Trp Phe 4145 4150 4155 Asp Pro Val Glu Asn Glu Ala Ile His Glu Val Tyr Ala Lys Leu 4160 4165 4170 Gly Pro Ile Val Ala Asn Ala Met Leu Lys Cys Val Ala Phe Cys 4175 4180 4185 Asp Ala Ile Val Glu Lys Gly Tyr Ile Gly Val Ile Thr Leu Asp 4190 4195 4200 Asn Gln Asp Leu Asn Gly Asn Phe Tyr Asp Phe Gly Asp Phe Val 4205 4210 4215 Lys Thr Ala Pro Gly Phe Gly Cys Ala Cys Val Thr Ser Tyr Tyr 4220 4225 4230 Ser Tyr Met Met Pro Leu Met Gly Met Thr Ser Cys Leu Glu Ser 4235 4240 4245 Glu Asn Phe Val Lys Ser Asp Ile Tyr Gly Ser Asp Tyr Lys Gln 4250 4255 4260 Tyr Asp Leu Leu Ala Tyr Asp Phe Thr Glu His Lys Glu Tyr Leu 4265 4270 4275 Phe Gln Lys Tyr Phe Lys Tyr Trp Asp Arg Thr Tyr His Pro Asn 4280 4285 4290 Cys Ser Asp Cys Thr Ser Asp Glu Cys Ile Ile His Cys Ala Asn 4295 4300 4305 Phe Asn Thr Leu Phe Ser Met Thr Ile Pro Met Thr Ala Phe Gly 4310 4315 4320 Pro Leu Val Arg Lys Val His Ile Asp Gly Val Pro Val Val Val 4325 4330 4335 Thr Ala Gly Tyr His Phe Lys Gln Leu Gly Ile Val Trp Asn Leu 4340 4345 4350 Asp Val Lys Leu Asp Thr Met Lys Leu Ser Met Thr Asp Leu Leu 4355 4360 4365 Arg Phe Val Thr Asp Pro Thr Leu Leu Val Ala Ser Ser Pro Ala 4370 4375 4380 Leu Leu Asp Gln Arg Thr Val Cys Phe Ser Ile Ala Ala Leu Ser 4385 4390 4395 Thr Gly Ile Thr Tyr Gln Thr Val Lys Pro Gly His Phe Asn Lys 4400 4405 4410 Asp Phe Tyr Asp Phe Ile Thr Glu Arg Gly Phe Phe Glu Glu Gly 4415 4420 4425 Ser Glu Leu Thr Leu Lys His Phe Phe Phe Ala Gln Gly Gly Glu 4430 4435 4440 Ala Ala Met Thr Asp Phe Asn Tyr Tyr Arg Tyr Asn Arg Val Thr 4445 4450 4455 Val Leu Asp Ile Cys Gln Ala Gln Phe Val Tyr Lys Ile Val Gly 4460 4465 4470 Lys Tyr Phe Glu Cys Tyr Asp Gly Gly Cys Ile Asn Ala Arg Glu 4475 4480 4485 Val Val Val Thr Asn Tyr Asp Lys Ser Ala Gly Tyr Pro Leu Asn 4490 4495 4500 Lys Phe Gly Lys Ala Arg Leu Tyr Tyr Glu Thr Leu Ser Tyr Glu 4505 4510 4515 Glu Gln Asp Ala Leu Phe Ala Leu Thr Lys Arg Asn Val Leu Pro 4520 4525 4530 Thr Met Thr Gln Met Asn Leu Lys Tyr Ala Ile Ser Gly Lys Ala 4535 4540 4545 Arg Ala Arg Thr Val Gly Gly Val Ser Leu Leu Ser Thr Met Thr 4550 4555 4560 Thr Arg Gln Tyr His Gln Lys His Leu Lys Ser Ile Ala Ala Thr 4565 4570 4575 Arg Asn Ala Thr Val Val Ile Gly Ser Thr Lys Phe Tyr Gly Gly 4580 4585 4590 Trp Asp Asn Met Leu Lys Asn Leu Met Arg Asp Val Asp Asn Gly 4595 4600 4605 Cys Leu Met Gly Trp Asp Tyr Pro Lys Cys Asp Arg Ala Leu Pro 4610 4615 4620 Asn Met Ile Arg Met Ala Ser Ala Met Ile Leu Gly Ser Lys His 4625 4630 4635 Val Gly Cys Cys Thr His Asn Asp Arg Phe Tyr Arg Leu Ser Asn 4640 4645 4650 Glu Leu Ala Gln Val Leu Thr Glu Val Val His Cys Thr Gly Gly 4655 4660 4665 Phe Tyr Phe Lys Pro Gly Gly Thr Thr Ser Gly Asp Gly Thr Thr 4670 4675 4680 Ala Tyr Ala Asn Ser Ala Phe Asn Ile Phe Gln Ala Val Ser Ala 4685 4690 4695 Asn Val Asn Lys Leu Leu Gly Val Asp Ser Asn Ala Cys Asn Asn 4700 4705 4710 Val Thr Val Lys Ser Ile Gln Arg Lys Ile Tyr Asp Asn Cys Tyr 4715 4720 4725 Arg Ser Ser Ser Ile Asp Glu Glu Phe Val Val Glu Tyr Phe Ser 4730 4735 4740 Tyr Leu Arg Lys His Phe Ser Met Met Ile Leu Ser Asp Asp Gly 4745 4750 4755 Val Val Cys Tyr Asn Lys Asp Tyr Ala Asp Leu Gly Tyr Val Ala 4760 4765 4770 Asp Ile Asn Ala Phe Lys Ala Thr Leu Tyr Tyr Gln Asn Asn Val 4775 4780 4785 Phe Met Ser Thr Ser Lys Cys Trp Val Glu Pro Asp Leu Ser Val 4790 4795 4800 Gly Pro His Glu Phe Cys Ser Gln His Thr Leu Gln Ile Val Gly 4805 4810 4815 Pro Asp Gly Asp Tyr Tyr Leu Pro Tyr Pro Asp Pro Ser Arg Ile 4820 4825 4830 Leu Ser Ala Gly Val Phe Val Asp Asp Ile Val Lys Thr Asp Asn 4835 4840 4845 Val Ile Met Leu Glu Arg Tyr Val Ser Leu Ala Ile Asp Ala Tyr 4850 4855 4860 Pro Leu Thr Lys His Pro Lys Pro Ala Tyr Gln Lys Val Phe Tyr 4865 4870 4875 Thr Leu Leu Asp Trp Val Lys His Leu Gln Lys Asn Leu Asn Ala 4880 4885 4890 Gly Val Leu Asp Ser Phe Ser Val Thr Met Leu Glu Glu Gly Gln 4895 4900 4905 Asp Lys Phe Trp Ser Glu Glu Phe Tyr Ala Ser Leu Tyr Glu Lys 4910 4915 4920 Ser Thr Val Leu Gln Ala Ala Gly Met Cys Val Val Cys Gly Ser 4925 4930 4935 Gln Thr Val Leu Arg Cys Gly Asp Cys Leu Arg Arg Pro Leu Leu 4940 4945 4950 Cys Thr Lys Cys Ala Tyr Asp His Val Met Gly Thr Lys His Lys 4955 4960 4965 Phe Ile Met Ser Ile Thr Pro Tyr Val Cys Ser Phe Asn Gly Cys 4970 4975 4980 Asn Val Asn Asp Val Thr Lys Leu Phe Leu Gly Gly Leu Ser Tyr 4985 4990 4995 Tyr Cys Met Asn His Lys Pro Gln Leu Ser Phe Pro Leu Cys Ala 5000 5005 5010 Asn Gly Asn Val Phe Gly Leu Tyr Lys Ser Ser Ala Val Gly Ser 5015 5020 5025 Glu Ala Val Glu Asp Phe Asn Lys Leu Ala Val Ser Asp Trp Thr 5030 5035 5040 Asn Val Glu Asp Tyr Lys Leu Ala Asn Asn Val Lys Glu Ser Leu 5045 5050 5055 Lys Ile Phe Ala Ala Glu Thr Val Lys Ala Lys Glu Glu Ser Val 5060 5065 5070 Lys Ser Glu Tyr Ala Tyr Ala Val Leu Lys Glu Val Ile Gly Pro 5075 5080 5085 Lys Glu Ile Val Leu Gln Trp Glu Ala Ser Lys Thr Lys Pro Pro 5090 5095 5100 Leu Asn Arg Asn Ser Val Phe Thr Cys Phe Gln Ile Ser Lys Asp 5105 5110 5115 Thr Lys Ile Gln Leu Gly Glu Phe Val Phe Glu Gln Ser Glu Tyr 5120 5125 5130 Gly Ser Asp Ser Val Tyr Tyr Lys Ser Thr Ser Thr Tyr Lys Leu 5135 5140 5145 Thr Pro Gly Met Ile Phe Val Leu Thr Ser His Asn Val Ser Pro 5150 5155 5160 Leu Lys Ala Pro Ile Leu Val Asn Gln Glu Lys Tyr Asn Thr Ile 5165 5170 5175 Ser Lys Leu Tyr Pro Val Phe Asn Ile Ala Glu Ala Tyr Asn Thr 5180 5185 5190 Leu Val Pro Tyr Tyr Gln Met Ile Gly Lys Gln Lys Phe Thr Thr 5195 5200 5205 Ile Gln Gly Pro Pro Gly Ser Gly Lys Ser His Cys Val Ile Gly 5210 5215 5220 Leu Gly Leu Tyr Tyr Pro Gln Ala Arg Ile Val Tyr Thr Ala Cys 5225 5230 5235 Ser His Ala Ala Val Asp Ala Leu Cys Glu Lys Ala Ala Lys Asn 5240 5245 5250 Phe Asn Val Asp Arg Cys Ser Arg Ile Ile Pro Gln Arg Ile Arg 5255 5260 5265 Val Asp Cys Tyr Thr Gly Phe Lys Pro Asn Asn Thr Asn Ala Gln 5270 5275 5280 Tyr Leu Phe Cys Thr Val Asn Ala Leu Pro Glu Ala Ser Cys Asp 5285 5290 5295 Ile Val Val Val Asp Glu Val Ser Met Cys Thr Asn Tyr Asp Leu 5300 5305 5310 Ser Val Ile Asn Ser Arg Leu Ser Tyr Lys His Ile Val Tyr Val 5315 5320 5325 Gly Asp Pro Gln Gln Leu Pro Ala Pro Arg Thr Leu Ile Asn Lys 5330 5335 5340 Gly Val Leu Gln Pro Gln Asp Tyr Asn Val Val Thr Lys Arg Met 5345 5350 5355 Cys Thr Leu Gly Pro Asp Val Phe Leu His Lys Cys Tyr Arg Cys 5360 5365 5370 Pro Ala Glu Ile Val Lys Thr Val Ser Ala Leu Val Tyr Glu Asn 5375 5380 5385 Lys Phe Val Pro Val Asn Pro Glu Ser Lys Gln Cys Phe Lys Met 5390 5395 5400 Phe Val Lys Gly Gln Val Gln Ile Glu Ser Asn Ser Ser Ile Asn 5405 5410 5415 Asn Lys Gln Leu Glu Val Val Lys Ala Phe Leu Ala His Asn Pro 5420 5425 5430 Lys Trp Arg Lys Ala Val Phe Ile Ser Pro Tyr Asn Ser Gln Asn 5435 5440 5445 Tyr Val Ala Arg Arg Leu Leu Gly Leu Gln Thr Gln Thr Val Asp 5450 5455 5460 Ser Ala Gln Gly Ser Glu Tyr Asp Tyr Val Ile Tyr Thr Gln Thr 5465 5470 5475 Ser Asp Thr Gln His Ala Thr Asn Val Asn Arg Phe Asn Val Ala 5480 5485 5490 Ile Thr Arg Ala Lys Val Gly Ile Leu Cys Ile Met Cys Asp Arg 5495 5500 5505 Thr Met Tyr Glu Asn Leu Asp Phe Tyr Glu Leu Lys Asp Ser Lys 5510 5515 5520 Ile Gly Leu Gln Ala Lys Pro Glu Thr Cys Gly Leu Phe Lys Asp 5525 5530 5535 Cys Ser Lys Ser Glu Gln Tyr Ile Pro Pro Ala Tyr Ala Thr Thr 5540 5545 5550 Tyr Met Ser Leu Ser Asp Asn Phe Lys Thr Ser Asp Gly Leu Ala 5555 5560 5565 Val Asn Ile Gly Thr Lys Asp Val Lys Tyr Ala Asn Val Ile Ser 5570 5575 5580 Tyr Met Gly Phe Arg Phe Glu Ala Asn Ile Pro Gly Tyr His Thr 5585 5590 5595 Leu Phe Cys Thr Arg Asp Phe Ala Met Arg Asn Val Arg Ala Trp 5600 5605 5610 Leu Gly Phe Asp Val Glu Gly Ala His Val Cys Gly Asp Asn Val 5615 5620 5625 Gly Thr Asn Val Pro Leu Gln Leu Gly Phe Ser Asn Gly Val Asp 5630 5635 5640 Phe Val Val Gln Thr Glu Gly Cys Val Ile Thr Glu Lys Gly Asn 5645 5650 5655 Ser Ile Glu Val Val Lys Ala Arg Ala Pro Pro Gly Glu Gln Phe 5660 5665 5670 Ala His Leu Ile Pro Leu Met Arg Lys Gly Gln Pro Trp His Ile 5675 5680 5685 Val Arg Arg Arg Ile Val Gln Met Val Cys Asp Tyr Phe Asp Gly 5690 5695 5700 Leu Ser Asp Ile Leu Ile Phe Val Leu Trp Ala Gly Gly Leu Glu 5705 5710 5715 Leu Thr Thr Met Arg Tyr Phe Val Lys Ile Gly Arg Pro Gln Lys 5720 5725 5730 Cys Glu Cys Gly Lys Ser Ala Thr Cys Tyr Ser Ser Ser Gln Ser 5735 5740 5745 Val Tyr Ala Cys Phe Lys His Ala Leu Gly Cys Asp Tyr Leu Tyr 5750 5755 5760 Asn Pro Tyr Cys Ile Asp Ile Gln Gln Trp Gly Tyr Thr Gly Ser 5765 5770 5775 Leu Ser Met Asn His His Glu Val Cys Asn Ile His Arg Asn Glu 5780 5785 5790 His Val Ala Ser Gly Asp Ala Ile Met Thr Arg Cys Leu Ala Ile 5795 5800 5805 His Asp Cys Phe Val Lys Arg Val Asp Trp Ser Ile Val Tyr Pro 5810 5815 5820 Phe Ile Asp Asn Glu Glu Lys Ile Asn Lys Ala Gly Arg Ile Val 5825 5830 5835 Gln Ser His Val Met Lys Ala Ala Leu Lys Ile Phe Asn Pro Ala 5840 5845 5850 Ala Ile His Asp Val Gly Asn Pro Lys Gly Ile Arg Cys Ala Thr 5855 5860 5865 Thr Pro Ile Pro Trp Phe Cys Tyr Asp Arg Asp Pro Ile Asn Asn 5870 5875 5880 Asn Val Arg Cys Leu Asp Tyr Asp Tyr Met Val His Gly Gln Met 5885 5890 5895 Asn Gly Leu Met Leu Phe Trp Asn Cys Asn Val Asp Met Tyr Pro 5900 5905 5910 Glu Phe Ser Ile Val Cys Arg Phe Asp Thr Arg Thr Arg Ser Lys 5915 5920 5925 Leu Ser Leu Glu Gly Cys Asn Gly Gly Ala Leu Tyr Val Asn Asn 5930 5935 5940 His Ala Phe His Thr Pro Ala Tyr Asp Arg Arg Ala Phe Ala Lys 5945 5950 5955 Leu Lys Pro Met Pro Phe Phe Tyr Tyr Asp Asp Ser Asn Cys Glu 5960 5965 5970 Leu Val Asp Gly Gln Pro Asn Tyr Val Pro Leu Lys Ser Asn Val 5975 5980 5985 Cys Ile Thr Lys Cys Asn Ile Gly Gly Ala Val Cys Lys Lys His 5990 5995 6000 Ala Ala Leu Tyr Arg Ala Tyr Val Glu Asp Tyr Asn Ile Phe Met 6005 6010 6015 Gln Ala Gly Phe Thr Ile Trp Cys Pro Gln Asn Phe Asp Thr Tyr 6020 6025 6030 Met Leu Trp His Gly Phe Val Asn Ser Lys Ala Leu Gln Ser Leu 6035 6040 6045 Glu Asn Val Ala Phe Asn Val Val Lys Lys Gly Ala Phe Thr Gly 6050 6055 6060 Leu Lys Gly Asp Leu Pro Thr Ala Val Ile Ala Asp Lys Ile Met 6065 6070 6075 Val Arg Asp Gly Pro Thr Asp Lys Cys Ile Phe Thr Asn Lys Thr 6080 6085 6090 Ser Leu Pro Thr Asn Val Ala Phe Glu Leu Tyr Ala Lys Arg Lys 6095 6100 6105 Leu Gly Leu Thr Pro Pro Leu Thr Ile Leu Arg Asn Leu Gly Val 6110 6115 6120 Val Ala Thr Tyr Lys Phe Val Leu Trp Asp Tyr Glu Ala Glu Arg 6125 6130 6135 Pro Phe Ser Asn Phe Thr Lys Gln Val Cys Ser Tyr Thr Asp Leu 6140 6145 6150 Asp Ser Glu Val Val Thr Cys Phe Asp Asn Ser Ile Ala Gly Ser 6155 6160 6165 Phe Glu Arg Phe Thr Thr Thr Arg Asp Ala Val Leu Ile Ser Asn 6170 6175 6180 Asn Ala Val Lys Gly Leu Ser Ala Ile Lys Leu Gln Tyr Gly Leu 6185 6190 6195 Leu Asn Asp Leu Pro Val Ser Thr Val Gly Asn Lys Pro Val Thr 6200 6205 6210 Trp Tyr Ile Tyr Val Arg Lys Asn Gly Glu Tyr Val Glu Gln Ile 6215 6220 6225 Asp Ser Tyr Tyr Thr Gln Gly Arg Thr Phe Glu Thr Phe Lys Pro 6230 6235 6240 Arg Ser Thr Met Glu Glu Asp Phe Leu Ser Met Asp Thr Thr Leu 6245 6250 6255 Phe Ile Gln Lys Tyr Gly Leu Glu Asp Tyr Gly Phe Glu His Val 6260 6265 6270 Val Phe Gly Asp Val Ser Lys Thr Thr Ile Gly Gly Met His Leu 6275 6280 6285 Leu Ile Ser Gln Val Arg Leu Ala Lys Met Gly Leu Phe Ser Val 6290 6295 6300 Gln Glu Phe Met Asn Asn Ser Asp Ser Thr Leu Lys Ser Cys Cys 6305 6310 6315 Ile Thr Tyr Ala Asp Asp Pro Ser Ser Lys Asn Val Cys Thr Tyr 6320 6325 6330 Met Asp Ile Leu Leu Asp Asp Phe Val Thr Ile Ile Lys Ser Leu 6335 6340 6345 Asp Leu Asn Val Val Ser Lys Val Val Asp Val Ile Val Asp Cys 6350 6355 6360 Lys Ala Trp Arg Trp Met Leu Trp Cys Glu Asn Ser His Ile Lys 6365 6370 6375 Thr Phe Tyr Pro Gln Leu Gln Ser Ala Glu Trp Asn Pro Gly Tyr 6380 6385 6390 Ser Met Pro Thr Leu Tyr Lys Ile Gln Arg Met Cys Leu Glu Arg 6395 6400 6405 Cys Asn Leu Tyr Asn Tyr Gly Ala Gln Val Lys Leu Pro Asp Gly 6410 6415 6420 Ile Thr Thr Asn Val Val Lys Tyr Thr Gln Leu Cys Gln Tyr Leu 6425 6430 6435 Asn Thr Thr Thr Leu Cys Val Pro His Lys Met Arg Val Leu His 6440 6445 6450 Leu Gly Ala Ala Gly Ala Ser Gly Val Ala Pro Gly Ser Thr Val 6455 6460 6465 Leu Arg Arg Trp Leu Pro Asp Asp Ala Ile Leu Val Asp Asn Asp 6470 6475 6480 Leu Arg Asp Tyr Val Ser Asp Ala Asp Phe Ser Val Thr Gly Asp 6485 6490 6495 Cys Thr Ser Leu Tyr Ile Glu Asp Lys Phe Asp Leu Leu Val Ser 6500 6505 6510 Asp Leu Tyr Asp Gly Ser Thr Lys Ser Ile Asp Gly Glu Asn Thr 6515 6520 6525 Ser Lys Asp Gly Phe Phe Thr Tyr Ile Asn Gly Phe Ile Lys Glu 6530 6535 6540 Lys Leu Ser Leu Gly Gly Ser Val Ala Ile Lys Ile Thr Glu Phe 6545 6550 6555 Ser Trp Asn Lys Asp Leu Tyr Glu Leu Ile Gln Arg Phe Glu Tyr 6560 6565 6570 Trp Thr Val Phe Cys Thr Ser Val Asn Thr Ser Ser Ser Glu Gly 6575 6580 6585 Phe Leu Ile Gly Ile Asn Tyr Leu Gly Pro Tyr Cys Asp Lys Ala 6590 6595 6600 Ile Val Asp Gly Asn Ile Met His Ala Asn Tyr Ile Phe Trp Arg 6605 6610 6615 Asn Ser Thr Ile Met Ala Leu Ser His Asn Ser Val Leu Asp Thr 6620 6625 6630 Pro Lys Phe Lys Cys Arg Cys Asn Asn Ala Leu Ile Val Asn Leu 6635 6640 6645 Lys Glu Lys Glu Leu Asn Glu Met Val Ile Gly Leu Leu Arg Lys 6650 6655 6660 Gly Lys Leu Leu Ile Arg Asn Asn Gly Lys Leu Leu Asn Phe Gly 6665 6670 6675 Asn His Phe Val Asn Thr Pro 6680 6685 <210> 21 <211> 6603 <212> PRT <213> avian infectious bronchitis virus <220> <221> MISC_FEATURE <223> ORF 1AB <400> 21 Met Ala Ser Ser Leu Lys Gln Gly Val Ser Pro Lys Pro Arg Asp Val 1 5 10 15 Ile Leu Val Ser Lys Asp Ile Pro Glu Gln Leu Cys Asp Ala Leu Phe 20 25 30 Phe Tyr Thr Ser His Asn Pro Lys Asp Tyr Ala Asp Ala Phe Ala Val 35 40 45 Arg Gln Lys Phe Asp Arg Ser Leu Gln Thr Gly Lys Gln Phe Lys Phe 50 55 60 Glu Thr Val Cys Gly Leu Phe Leu Leu Lys Gly Val Asp Lys Ile Thr 65 70 75 80 Pro Gly Val Pro Ala Lys Val Leu Lys Ala Thr Ser Lys Leu Ala Asp 85 90 95 Leu Glu Asp Ile Phe Gly Val Ser Pro Leu Ala Arg Lys Tyr Arg Glu 100 105 110 Leu Leu Lys Thr Ala Cys Gln Trp Ser Leu Thr Val Glu Ala Leu Asp 115 120 125 Val Arg Ala Gln Thr Leu Asp Glu Ile Phe Asp Pro Thr Glu Ile Leu 130 135 140 Trp Leu Gln Val Ala Ala Lys Ile His Val Ser Ser Met Ala Met Arg 145 150 155 160 Arg Leu Val Gly Glu Val Thr Ala Lys Val Met Asp Ala Leu Gly Ser 165 170 175 Asn Leu Ser Ala Leu Phe Gln Ile Val Lys Gln Gln Ile Ala Arg Ile 180 185 190 Phe Gln Lys Ala Leu Ala Ile Phe Glu Asn Val Asn Glu Leu Pro Gln 195 200 205 Arg Ile Ala Ala Leu Lys Met Ala Phe Ala Lys Cys Ala Arg Ser Ile 210 215 220 Thr Val Val Val Val Glu Arg Thr Leu Val Val Lys Glu Phe Ala Gly 225 230 235 240 Thr Cys Leu Ala Ser Ile Asn Gly Ala Val Ala Lys Phe Phe Glu Glu 245 250 255 Leu Pro Asn Gly Phe Met Gly Ser Lys Ile Phe Thr Thr Leu Ala Phe 260 265 270 Phe Lys Glu Ala Ala Val Arg Val Val Glu Asn Ile Pro Asn Ala Pro 275 280 285 Arg Gly Thr Lys Gly Phe Glu Val Val Gly Asn Ala Lys Gly Thr Gln 290 295 300 Val Val Val Arg Gly Met Arg Asn Asp Leu Thr Leu Leu Asp Gln Lys 305 310 315 320 Ala Asp Ile Pro Val Glu Pro Glu Gly Trp Ser Ala Ile Leu Asp Gly 325 330 335 His Leu Cys Tyr Val Phe Arg Ser Gly Asp Arg Phe Tyr Ala Ala Pro 340 345 350 Leu Ser Gly Asn Phe Ala Leu Ser Asp Val His Cys Cys Glu Arg Val 355 360 365 Val Cys Leu Ser Asp Gly Val Thr Pro Glu Ile Asn Asp Gly Leu Ile 370 375 380 Leu Ala Ala Ile Tyr Ser Ser Phe Ser Val Ser Glu Leu Val Thr Ala 385 390 395 400 Leu Lys Lys Gly Glu Pro Phe Lys Phe Leu Gly His Lys Phe Val Tyr 405 410 415 Ala Lys Asp Ala Ala Val Ser Phe Thr Leu Ala Lys Ala Ala Thr Ile 420 425 430 Ala Asp Val Leu Arg Leu Phe Gln Ser Ala Arg Val Ile Ala Glu Asp 435 440 445 Val Trp Ser Ser Phe Thr Glu Lys Ser Phe Glu Phe Trp Lys Leu Ala 450 455 460 Tyr Gly Lys Val Arg Asn Leu Glu Glu Phe Val Lys Thr Tyr Val Cys 465 470 475 480 Lys Ala Gln Met Ser Ile Val Ile Leu Ala Ala Val Leu Gly Glu Asp 485 490 495 Ile Trp His Leu Val Ser Gln Val Ile Tyr Lys Leu Gly Val Leu Phe 500 505 510 Thr Lys Val Val Asp Phe Cys Asp Lys His Trp Lys Gly Phe Cys Val 515 520 525 Gln Leu Lys Arg Ala Lys Leu Ile Val Thr Glu Thr Phe Cys Val Leu 530 535 540 Lys Gly Val Ala Gln His Cys Phe Gln Leu Leu Leu Asp Ala Ile His 545 550 555 560 Ser Leu Tyr Lys Ser Phe Lys Lys Cys Ala Leu Gly Arg Ile His Gly 565 570 575 Asp Leu Leu Phe Trp Lys Gly Gly Val His Lys Ile Val Gln Asp Gly 580 585 590 Asp Glu Ile Trp Phe Asp Ala Ile Asp Ser Val Asp Val Glu Asp Leu 595 600 605 Gly Val Val Gln Glu Lys Ser Ile Asp Phe Glu Val Cys Asp Asp Val 610 615 620 Thr Leu Pro Glu Asn Gln Pro Gly His Met Val Gln Ile Glu Asp Asp 625 630 635 640 Gly Lys Asn Tyr Met Phe Phe Arg Phe Lys Lys Asp Glu Asn Ile Tyr 645 650 655 Tyr Thr Pro Met Ser Gln Leu Gly Ala Ile Asn Val Val Cys Lys Ala 660 665 670 Gly Gly Lys Thr Val Thr Phe Gly Glu Thr Thr Val Gln Glu Ile Pro 675 680 685 Pro Pro Asp Val Val Pro Ile Lys Val Ser Ile Glu Cys Cys Gly Glu 690 695 700 Pro Trp Asn Thr Ile Phe Lys Lys Ala Tyr Lys Glu Pro Ile Glu Val 705 710 715 720 Asp Thr Asp Leu Thr Val Glu Gln Leu Leu Ser Val Ile Tyr Glu Lys 725 730 735 Met Cys Asp Asp Leu Lys Leu Phe Pro Glu Ala Pro Glu Pro Pro Pro 740 745 750 Phe Glu Asn Val Ala Leu Val Asp Lys Asn Gly Lys Asp Leu Asp Cys 755 760 765 Ile Lys Ser Cys His Leu Ile Tyr Arg Asp Tyr Glu Ser Asp Asp Asp 770 775 780 Ile Glu Glu Glu Asp Ala Glu Glu Cys Asp Thr Asp Ser Gly Glu Ala 785 790 795 800 Glu Glu Cys Asp Thr Asn Ser Glu Cys Glu Glu Glu Asp Glu Asp Thr 805 810 815 Lys Val Leu Ala Leu Ile Gln Asp Pro Ala Ser Ile Lys Tyr Pro Leu 820 825 830 Pro Leu Asp Glu Asp Tyr Ser Val Tyr Asn Gly Cys Ile Val His Lys 835 840 845 Asp Ala Leu Asp Val Val Asn Leu Pro Ser Gly Glu Glu Thr Phe Val 850 855 860 Val Asn Asn Cys Phe Glu Gly Ala Val Lys Pro Leu Pro Gln Lys Val 865 870 875 880 Val Asp Val Leu Gly Asp Trp Gly Glu Ala Val Asp Ala Gln Glu Gln 885 890 895 Leu Cys Gln Gln Glu Pro Leu Gln His Thr Phe Glu Glu Pro Val Glu 900 905 910 Asn Ser Thr Gly Ser Ser Lys Thr Met Thr Glu Gln Val Val Val Glu 915 920 925 Asp Gln Glu Leu Pro Val Val Glu Gln Asp Gln Asp Val Val Val Tyr 930 935 940 Thr Pro Thr Asp Leu Glu Val Ala Lys Glu Thr Ala Glu Glu Val Asp 945 950 955 960 Glu Phe Ile Leu Ile Phe Ala Val Pro Lys Glu Glu Val Val Ser Gln 965 970 975 Lys Asp Gly Ala Gln Ile Lys Gln Glu Pro Ile Gln Val Val Lys Pro 980 985 990 Gln Arg Glu Lys Lys Ala Lys Lys Phe Lys Val Lys Pro Ala Thr Cys 995 1000 1005 Glu Lys Pro Lys Phe Leu Glu Tyr Lys Thr Cys Val Gly Asp Leu 1010 1015 1020 Thr Val Val Ile Ala Lys Ala Leu Asp Glu Phe Lys Glu Phe Cys 1025 1030 1035 Ile Val Asn Ala Ala Asn Glu His Met Thr His Gly Ser Gly Val 1040 1045 1050 Ala Lys Ala Ile Ala Asp Phe Cys Gly Leu Asp Phe Val Glu Tyr 1055 1060 1065 Cys Glu Asp Tyr Val Lys Lys His Gly Pro Gln Gln Arg Leu Val 1070 1075 1080 Thr Pro Ser Phe Val Lys Gly Ile Gln Cys Val Asn Asn Val Val 1085 1090 1095 Gly Pro Arg His Gly Asp Asn Asn Leu His Glu Lys Leu Val Ala 1100 1105 1110 Ala Tyr Lys Asn Val Leu Val Asp Gly Val Val Asn Tyr Val Val 1115 1120 1125 Pro Val Leu Ser Leu Gly Ile Phe Gly Val Asp Phe Lys Met Ser 1130 1135 1140 Ile Asp Ala Met Arg Glu Ala Phe Glu Gly Cys Thr Ile Arg Val 1145 1150 1155 Leu Leu Phe Ser Leu Ser Gln Glu His Ile Asp Tyr Phe Asp Val 1160 1165 1170 Thr Cys Lys Gln Lys Thr Ile Tyr Leu Thr Glu Asp Gly Val Lys 1175 1180 1185 Tyr Arg Ser Ile Val Leu Lys Pro Gly Asp Ser Leu Gly Gln Phe 1190 1195 1200 Gly Gln Val Tyr Ala Lys Asn Lys Ile Val Phe Thr Ala Asp Asp 1205 1210 1215 Val Glu Asp Lys Glu Ile Leu Tyr Val Pro Thr Thr Asp Lys Ser 1220 1225 1230 Ile Leu Glu Tyr Tyr Gly Leu Asp Ala Gln Lys Tyr Val Ile Tyr 1235 1240 1245 Leu Gln Thr Leu Ala Gln Lys Trp Asn Val Gln Tyr Arg Asp Asn 1250 1255 1260 Phe Leu Ile Leu Glu Trp Arg Asp Gly Asn Cys Trp Ile Ser Ser 1265 1270 1275 Ala Ile Val Leu Leu Gln Ala Ala Lys Ile Arg Phe Lys Gly Phe 1280 1285 1290 Leu Thr Glu Ala Trp Ala Lys Leu Leu Gly Gly Asp Pro Thr Asp 1295 1300 1305 Phe Val Ala Trp Cys Tyr Ala Ser Cys Thr Ala Lys Val Gly Asp 1310 1315 1320 Phe Ser Asp Ala Asn Trp Leu Leu Ala Asn Leu Ala Glu His Phe 1325 1330 1335 Asp Ala Asp Tyr Thr Asn Ala Phe Leu Lys Lys Arg Val Ser Cys 1340 1345 1350 Asn Cys Gly Ile Lys Ser Tyr Glu Leu Arg Gly Leu Glu Ala Cys 1355 1360 1365 Ile Gln Pro Val Arg Ala Thr Asn Leu Leu His Phe Lys Thr Gln 1370 1375 1380 Tyr Ser Asn Cys Pro Thr Cys Gly Ala Asn Asn Thr Asp Glu Val 1385 1390 1395 Ile Glu Ala Ser Leu Pro Tyr Leu Leu Leu Phe Ala Thr Asp Gly 1400 1405 1410 Pro Ala Thr Val Asp Cys Asp Glu Asp Ala Val Gly Thr Val Val 1415 1420 1425 Phe Val Gly Ser Thr Asn Ser Gly His Cys Tyr Thr Gln Ala Ala 1430 1435 1440 Gly Gln Ala Phe Asp Asn Leu Ala Lys Asp Arg Lys Phe Gly Lys 1445 1450 1455 Lys Ser Pro Tyr Ile Thr Ala Met Tyr Thr Arg Phe Ala Phe Lys 1460 1465 1470 Asn Glu Thr Ser Leu Pro Val Ala Lys Gln Ser Lys Gly Lys Ser 1475 1480 1485 Lys Ser Val Lys Glu Asp Val Ser Asn Leu Ala Thr Ser Ser Lys 1490 1495 1500 Ala Ser Phe Asp Asn Leu Thr Asp Phe Glu Gln Trp Tyr Asp Ser 1505 1510 1515 Asn Ile Tyr Glu Ser Leu Lys Val Gln Glu Ser Pro Asp Asn Phe 1520 1525 1530 Asp Lys Tyr Val Ser Phe Thr Thr Lys Glu Asp Ser Lys Leu Pro 1535 1540 1545 Leu Thr Leu Lys Val Arg Gly Ile Lys Ser Val Val Asp Phe Arg 1550 1555 1560 Ser Lys Asp Gly Phe Ile Tyr Lys Leu Thr Pro Asp Thr Asp Glu 1565 1570 1575 Asn Ser Lys Ala Pro Val Tyr Tyr Pro Val Leu Asp Ala Ile Ser 1580 1585 1590 Leu Lys Ala Ile Trp Val Glu Gly Asn Ala Asn Phe Val Val Gly 1595 1600 1605 His Pro Asn Tyr Tyr Ser Lys Ser Leu His Ile Pro Thr Phe Trp 1610 1615 1620 Glu Asn Ala Glu Asn Phe Val Lys Met Gly Asp Lys Ile Gly Gly 1625 1630 1635 Val Thr Met Gly Leu Trp Arg Ala Glu His Leu Asn Lys Pro Asn 1640 1645 1650 Leu Glu Arg Ile Phe Asn Ile Ala Lys Lys Ala Ile Val Gly Ser 1655 1660 1665 Ser Val Val Thr Thr Gln Cys Gly Lys Leu Ile Gly Lys Ala Ala 1670 1675 1680 Thr Phe Ile Ala Asp Lys Val Gly Gly Gly Val Val Arg Asn Ile 1685 1690 1695 Thr Asp Ser Ile Lys Gly Leu Cys Gly Ile Thr Arg Gly His Phe 1700 1705 1710 Glu Arg Lys Met Ser Pro Gln Phe Leu Lys Thr Leu Met Phe Phe 1715 1720 1725 Leu Phe Tyr Phe Leu Lys Ala Ser Val Lys Ser Val Val Ala Ser 1730 1735 1740 Tyr Lys Thr Val Leu Cys Lys Val Val Leu Ala Thr Leu Leu Ile 1745 1750 1755 Val Trp Phe Val Tyr Thr Ser Asn Pro Val Met Phe Thr Gly Ile 1760 1765 1770 Arg Val Leu Asp Phe Leu Phe Glu Gly Ser Leu Cys Gly Pro Tyr 1775 1780 1785 Lys Asp Tyr Gly Lys Asp Ser Phe Asp Val Leu Arg Tyr Cys Ala 1790 1795 1800 Asp Asp Phe Ile Cys Arg Val Cys Leu His Asp Lys Asp Ser Leu 1805 1810 1815 His Leu Tyr Lys His Ala Tyr Ser Val Glu Gln Val Tyr Lys Asp 1820 1825 1830 Ala Ala Ser Gly Phe Ile Phe Asn Trp Asn Trp Leu Tyr Leu Val 1835 1840 1845 Phe Leu Ile Leu Phe Val Lys Pro Val Ala Gly Phe Val Ile Ile 1850 1855 1860 Cys Tyr Cys Val Lys Tyr Leu Val Leu Asn Ser Thr Val Leu Gln 1865 1870 1875 Thr Gly Val Cys Phe Leu Asp Trp Phe Val Gln Thr Val Phe Ser 1880 1885 1890 His Phe Asn Phe Met Gly Ala Gly Phe Tyr Phe Trp Leu Phe Tyr 1895 1900 1905 Lys Ile Tyr Ile Gln Val His His Ile Leu Tyr Cys Lys Asp Val 1910 1915 1920 Thr Cys Glu Val Cys Lys Arg Val Ala Arg Ser Asn Arg Gln Glu 1925 1930 1935 Val Ser Val Val Val Gly Gly Arg Lys Gln Ile Val His Val Tyr 1940 1945 1950 Thr Asn Ser Gly Tyr Asn Phe Cys Lys Arg His Asn Trp Tyr Cys 1955 1960 1965 Arg Asn Cys Asp Asp Tyr Gly His Gln Asn Thr Phe Met Ser Pro 1970 1975 1980 Glu Val Ala Gly Glu Leu Ser Glu Lys Leu Lys Arg His Val Lys 1985 1990 1995 Pro Thr Ala Tyr Ala Tyr His Val Val Asp Glu Ala Cys Leu Val 2000 2005 2010 Asp Asp Phe Val Asn Leu Lys Tyr Lys Ala Ala Thr Pro Gly Lys 2015 2020 2025 Asp Ser Ala Ser Ser Ala Val Lys Cys Phe Ser Val Thr Asp Phe 2030 2035 2040 Leu Lys Lys Ala Val Phe Leu Lys Glu Ala Leu Lys Cys Glu Gln 2045 2050 2055 Ile Ser Asn Asp Gly Phe Ile Val Cys Asn Thr Gln Ser Ala His 2060 2065 2070 Ala Leu Glu Glu Ala Lys Asn Ala Ala Ile Tyr Tyr Ala Gln Tyr 2075 2080 2085 Leu Cys Lys Pro Ile Leu Ile Leu Asp Gln Ala Leu Tyr Glu Gln 2090 2095 2100 Leu Val Val Glu Pro Val Ser Lys Ser Val Ile Asp Lys Val Cys 2105 2110 2115 Ser Ile Leu Ser Ser Ile Ile Ser Val Asp Thr Ala Ala Leu Asn 2120 2125 2130 Tyr Lys Ala Gly Thr Leu Arg Asp Ala Leu Leu Ser Ile Thr Lys 2135 2140 2145 Asp Glu Glu Ala Val Asp Met Ala Ile Phe Cys His Asn His Asp 2150 2155 2160 Val Asp Tyr Thr Gly Asp Gly Phe Thr Asn Val Ile Pro Ser Tyr 2165 2170 2175 Gly Ile Asp Thr Gly Lys Leu Thr Pro Arg Asp Arg Gly Phe Leu 2180 2185 2190 Ile Asn Ala Asp Ala Ser Ile Ala Asn Leu Arg Val Lys Asn Ala 2195 2200 2205 Pro Pro Val Val Trp Lys Phe Ser Glu Leu Ile Lys Leu Ser Asp 2210 2215 2220 Ser Cys Leu Lys Tyr Leu Ile Ser Ala Thr Val Lys Ser Gly Val 2225 2230 2235 Arg Phe Phe Ile Thr Lys Ser Gly Ala Lys Gln Val Ile Ala Cys 2240 2245 2250 His Thr Gln Lys Leu Leu Val Glu Lys Lys Ala Gly Gly Ile Val 2255 2260 2265 Ser Gly Thr Phe Lys Cys Phe Lys Ser Tyr Phe Lys Trp Leu Leu 2270 2275 2280 Ile Phe Tyr Ile Leu Phe Thr Ala Cys Cys Ser Gly Tyr Tyr Tyr 2285 2290 2295 Met Glu Val Ser Lys Ser Phe Val His Pro Met Tyr Asp Val Asn 2300 2305 2310 Ser Thr Leu His Val Glu Gly Phe Lys Val Ile Asp Lys Gly Val 2315 2320 2325 Leu Arg Glu Ile Val Pro Glu Asp Thr Cys Phe Ser Asn Lys Phe 2330 2335 2340 Val Asn Phe Asp Ala Phe Trp Gly Arg Pro Tyr Asp Asn Ser Arg 2345 2350 2355 Asn Cys Pro Ile Val Thr Ala Val Ile Asp Gly Asp Gly Thr Val 2360 2365 2370 Ala Thr Gly Val Pro Gly Phe Val Ser Trp Val Met Asp Gly Val 2375 2380 2385 Met Phe Ile His Met Thr Gln Thr Glu Arg Lys Pro Trp Tyr Ile 2390 2395 2400 Pro Thr Trp Phe Asn Arg Glu Ile Val Gly Tyr Thr Gln Asp Ser 2405 2410 2415 Ile Ile Thr Glu Gly Ser Phe Tyr Thr Ser Ile Ala Leu Phe Ser 2420 2425 2430 Ala Arg Cys Leu Tyr Leu Thr Ala Ser Asn Thr Pro Gln Leu Tyr 2435 2440 2445 Cys Phe Asn Gly Asp Asn Asp Ala Pro Gly Ala Leu Pro Phe Gly 2450 2455 2460 Ser Ile Ile Pro His Arg Val Tyr Phe Gln Pro Asn Gly Val Arg 2465 2470 2475 Leu Ile Val Pro Gln Gln Ile Leu His Thr Pro Tyr Val Val Lys 2480 2485 2490 Phe Val Ser Asp Ser Tyr Cys Arg Gly Ser Val Cys Glu Tyr Thr 2495 2500 2505 Arg Pro Gly Tyr Cys Val Ser Leu Asn Pro Gln Trp Val Leu Phe 2510 2515 2520 Asn Asp Glu Tyr Thr Ser Lys Pro Gly Val Phe Cys Gly Ser Thr 2525 2530 2535 Val Arg Glu Leu Met Phe Ser Met Val Ser Thr Phe Phe Thr Gly 2540 2545 2550 Val Asn Pro Asn Ile Tyr Met Gln Leu Ala Thr Met Phe Leu Ile 2555 2560 2565 Leu Val Val Val Val Leu Ile Phe Ala Met Val Ile Lys Phe Gln 2570 2575 2580 Gly Val Phe Lys Ala Tyr Ala Thr Thr Val Phe Ile Thr Met Leu 2585 2590 2595 Val Trp Val Ile Asn Ala Phe Ile Leu Cys Val His Ser Tyr Asn 2600 2605 2610 Ser Val Leu Ala Val Ile Leu Leu Val Leu Tyr Cys Tyr Ala Ser 2615 2620 2625 Leu Val Thr Ser Arg Asn Thr Val Ile Ile Met His Cys Trp Leu 2630 2635 2640 Val Phe Thr Phe Gly Leu Ile Val Pro Thr Trp Leu Ala Cys Cys 2645 2650 2655 Tyr Leu Gly Phe Ile Ile Tyr Met Tyr Thr Pro Leu Phe Leu Trp 2660 2665 2670 Cys Tyr Gly Thr Thr Lys Asn Thr Arg Lys Leu Tyr Asp Gly Asn 2675 2680 2685 Glu Phe Val Gly Asn Tyr Asp Leu Ala Ala Lys Ser Thr Phe Val 2690 2695 2700 Ile Arg Gly Ser Glu Phe Val Lys Leu Thr Asn Glu Ile Gly Asp 2705 2710 2715 Lys Phe Glu Ala Tyr Leu Ser Ala Tyr Ala Arg Leu Lys Tyr Tyr 2720 2725 2730 Ser Gly Thr Gly Ser Glu Gln Asp Tyr Leu Gln Ala Cys Arg Ala 2735 2740 2745 Trp Leu Ala Tyr Ala Leu Asp Gln Tyr Arg Asn Ser Gly Val Glu 2750 2755 2760 Ile Val Tyr Thr Pro Pro Arg Tyr Ser Ile Gly Val Ser Arg Leu 2765 2770 2775 Gln Ser Gly Phe Lys Lys Leu Val Ser Pro Ser Ser Ala Val Glu 2780 2785 2790 Lys Cys Ile Val Ser Val Ser Tyr Arg Gly Asn Asn Leu Asn Gly 2795 2800 2805 Leu Trp Leu Gly Asp Thr Ile Tyr Cys Pro Arg His Val Leu Gly 2810 2815 2820 Lys Phe Ser Gly Asp Gln Trp Asn Asp Val Leu Asn Leu Ala Asn 2825 2830 2835 Asn His Glu Phe Glu Val Thr Thr Gln His Gly Val Thr Leu Asn 2840 2845 2850 Val Val Ser Arg Arg Leu Lys Gly Ala Val Leu Ile Leu Gln Thr 2855 2860 2865 Ala Val Ala Asn Ala Glu Thr Pro Lys Tyr Lys Phe Ile Lys Ala 2870 2875 2880 Asn Cys Gly Asp Ser Phe Thr Ile Ala Cys Ala Tyr Gly Gly Thr 2885 2890 2895 Val Val Gly Leu Tyr Pro Val Thr Met Arg Ser Asn Gly Thr Ile 2900 2905 2910 Arg Ala Ser Phe Leu Ala Gly Ala Cys Gly Ser Val Gly Phe Asn 2915 2920 2925 Ile Glu Lys Gly Val Val Asn Phe Phe Tyr Met His His Leu Glu 2930 2935 2940 Leu Pro Asn Ala Leu His Thr Gly Thr Asp Leu Met Gly Glu Phe 2945 2950 2955 Tyr Gly Gly Tyr Val Asp Glu Glu Val Ala Gln Arg Val Pro Pro 2960 2965 2970 Asp Asn Leu Val Thr Asn Asn Ile Val Ala Trp Leu Tyr Ala Ala 2975 2980 2985 Ile Ile Ser Val Lys Glu Ser Ser Phe Ser Leu Pro Lys Trp Leu 2990 2995 3000 Glu Ser Thr Thr Val Ser Val Asp Asp Tyr Asn Lys Trp Ala Gly 3005 3010 3015 Asp Asn Gly Phe Thr Pro Phe Ser Thr Ser Thr Ala Ile Thr Lys 3020 3025 3030 Leu Ser Ala Ile Thr Gly Val Asp Val Cys Lys Leu Leu Arg Thr 3035 3040 3045 Ile Met Val Lys Asn Ser Gln Trp Gly Gly Asp Pro Ile Leu Gly 3050 3055 3060 Gln Tyr Asn Phe Glu Asp Glu Leu Thr Pro Glu Ser Val Phe Asn 3065 3070 3075 Gln Ile Gly Gly Val Arg Leu Gln Ser Ser Phe Val Arg Lys Ala 3080 3085 3090 Thr Ser Trp Phe Trp Ser Arg Cys Val Leu Ala Cys Phe Leu Phe 3095 3100 3105 Val Leu Cys Ala Ile Val Leu Phe Thr Ala Val Pro Leu Lys Phe 3110 3115 3120 Tyr Val Tyr Ala Ala Val Ile Leu Leu Met Ala Val Leu Phe Ile 3125 3130 3135 Ser Phe Thr Val Lys His Val Met Ala Tyr Met Asp Thr Phe Leu 3140 3145 3150 Leu Pro Thr Leu Ile Thr Val Ile Ile Gly Val Cys Ala Glu Val 3155 3160 3165 Pro Phe Ile Tyr Asn Thr Leu Ile Ser Gln Val Val Ile Phe Leu 3170 3175 3180 Ser Gln Trp Tyr Asp Pro Val Val Phe Asp Thr Met Val Pro Trp 3185 3190 3195 Met Phe Leu Pro Leu Val Leu Tyr Thr Ala Phe Lys Cys Val Gln 3200 3205 3210 Gly Cys Tyr Met Asn Ser Phe Asn Thr Ser Leu Leu Met Leu Tyr 3215 3220 3225 Gln Phe Val Lys Leu Gly Phe Val Ile Tyr Thr Ser Ser Asn Thr 3230 3235 3240 Leu Thr Ala Tyr Thr Glu Gly Asn Trp Glu Leu Phe Phe Glu Leu 3245 3250 3255 Val His Thr Thr Val Leu Ala Asn Val Ser Ser Asn Ser Leu Ile 3260 3265 3270 Gly Leu Phe Val Phe Lys Cys Ala Lys Trp Met Leu Tyr Tyr Cys 3275 3280 3285 Asn Ala Thr Tyr Leu Asn Asn Tyr Val Leu Met Ala Val Met Val 3290 3295 3300 Asn Cys Ile Gly Trp Leu Cys Thr Cys Tyr Phe Gly Leu Tyr Trp 3305 3310 3315 Trp Val Asn Lys Val Phe Gly Leu Thr Leu Gly Lys Tyr Asn Phe 3320 3325 3330 Lys Val Ser Val Asp Gln Tyr Arg Tyr Met Cys Leu His Lys Ile 3335 3340 3345 Asn Pro Pro Lys Thr Val Trp Glu Val Phe Ser Thr Asn Ile Leu 3350 3355 3360 Ile Gln Gly Ile Gly Gly Asp Arg Val Leu Pro Ile Ala Thr Val 3365 3370 3375 Gln Ala Lys Leu Ser Asp Val Lys Cys Thr Thr Val Val Leu Met 3380 3385 3390 Gln Leu Leu Thr Lys Leu Asn Val Glu Ala Asn Ser Lys Met His 3395 3400 3405 Val Tyr Leu Val Glu Leu His Asn Lys Ile Leu Ala Ser Asp Asp 3410 3415 3420 Val Gly Glu Cys Met Asp Asn Leu Leu Gly Met Leu Ile Thr Leu 3425 3430 3435 Phe Cys Ile Asp Ser Thr Ile Asp Leu Ser Glu Tyr Cys Asp Asp 3440 3445 3450 Ile Leu Lys Arg Ser Thr Val Leu Gln Ser Val Thr Gln Glu Phe 3455 3460 3465 Ser His Ile Pro Ser Tyr Ala Glu Tyr Glu Arg Ala Lys Asn Leu 3470 3475 3480 Tyr Glu Lys Val Leu Val Asp Ser Lys Asn Gly Gly Val Thr Gln 3485 3490 3495 Gln Glu Leu Ala Ala Tyr Arg Lys Ala Ala Asn Ile Ala Lys Ser 3500 3505 3510 Val Phe Asp Arg Asp Leu Ala Val Gln Lys Lys Leu Asp Ser Met 3515 3520 3525 Ala Glu Arg Ala Met Thr Thr Met Tyr Lys Glu Ala Arg Val Thr 3530 3535 3540 Asp Arg Arg Ala Lys Leu Val Ser Ser Leu His Ala Leu Leu Phe 3545 3550 3555 Ser Met Leu Lys Lys Ile Asp Ser Glu Lys Leu Asn Val Leu Phe 3560 3565 3570 Asp Gln Ala Ser Ser Gly Val Val Pro Leu Ala Thr Val Pro Ile 3575 3580 3585 Val Cys Ser Asn Lys Leu Thr Leu Val Ile Pro Asp Pro Glu Thr 3590 3595 3600 Trp Val Lys Cys Val Glu Gly Val His Val Thr Tyr Ser Thr Val 3605 3610 3615 Val Trp Asn Ile Asp Thr Val Ile Asp Ala Asp Gly Thr Glu Leu 3620 3625 3630 His Pro Thr Ser Thr Gly Ser Gly Leu Thr Tyr Cys Ile Ser Gly 3635 3640 3645 Ala Asn Ile Ala Trp Pro Leu Lys Val Asn Leu Thr Arg Asn Gly 3650 3655 3660 His Asn Lys Val Asp Val Val Leu Gln Asn Asn Glu Leu Met Pro 3665 3670 3675 His Gly Val Lys Thr Lys Ala Cys Val Ala Gly Val Asp Gln Ala 3680 3685 3690 His Cys Ser Val Glu Ser Lys Cys Tyr Tyr Thr Asn Ile Ser Gly 3695 3700 3705 Asn Ser Val Val Ala Ala Ile Thr Ser Ser Asn Pro Asn Leu Lys 3710 3715 3720 Val Ala Ser Phe Leu Asn Glu Ala Gly Asn Gln Ile Tyr Val Asp 3725 3730 3735 Leu Asp Pro Pro Cys Lys Phe Gly Met Lys Val Gly Val Lys Val 3740 3745 3750 Glu Val Val Tyr Leu Tyr Phe Ile Lys Asn Thr Arg Ser Ile Val 3755 3760 3765 Arg Gly Met Val Leu Gly Ala Ile Ser Asn Val Val Val Leu Gln 3770 3775 3780 Ser Lys Gly His Glu Thr Glu Glu Val Asp Ala Val Gly Ile Leu 3785 3790 3795 Ser Leu Cys Ser Phe Ala Val Asp Pro Ala Asp Thr Tyr Cys Lys 3800 3805 3810 Tyr Val Ala Ala Gly Asn Gln Pro Leu Gly Asn Cys Val Lys Met 3815 3820 3825 Leu Thr Val His Asn Gly Ser Gly Phe Ala Ile Thr Ser Lys Pro 3830 3835 3840 Ser Pro Thr Pro Asp Gln Asp Ser Tyr Gly Gly Ala Ser Val Cys 3845 3850 3855 Leu Tyr Cys Arg Ala His Ile Ala His Pro Gly Ser Val Gly Asn 3860 3865 3870 Leu Asp Gly Arg Cys Gln Phe Lys Gly Ser Phe Val Gln Ile Pro 3875 3880 3885 Thr Thr Glu Lys Asp Pro Val Gly Phe Cys Leu Arg Asn Lys Val 3890 3895 3900 Cys Thr Val Cys Gln Cys Trp Ile Gly Tyr Gly Cys Gln Cys Asp 3905 3910 3915 Ser Leu Arg Gln Pro Lys Ser Ser Val Gln Ser Val Ala Gly Ala 3920 3925 3930 Ser Asp Phe Asp Lys Asn Tyr Leu Asn Gly Tyr Gly Val Ala Val 3935 3940 3945 Arg Leu Gly Met Phe Gln Asn Leu Lys Arg Asn Cys Ala Arg Phe 3950 3955 3960 Gln Glu Leu Arg Asp Thr Glu Asp Gly Asn Leu Glu Tyr Leu Asp 3965 3970 3975 Ser Tyr Phe Val Val Lys Gln Thr Thr Pro Ser Asn Tyr Glu His 3980 3985 3990 Glu Lys Ser Cys Tyr Glu Asp Leu Lys Ser Glu Val Thr Ala Asp 3995 4000 4005 His Asp Phe Phe Val Phe Asn Lys Asn Ile Tyr Asn Ile Ser Arg 4010 4015 4020 Gln Arg Leu Thr Lys Tyr Thr Met Met Asp Phe Cys Tyr Ala Leu 4025 4030 4035 Arg His Phe Asp Pro Lys Asp Cys Glu Val Leu Lys Glu Ile Leu 4040 4045 4050 Val Thr Tyr Gly Cys Ile Glu Asp Tyr His Pro Lys Trp Phe Glu 4055 4060 4065 Glu Asn Lys Asp Trp Tyr Asp Pro Ile Glu Asn Ser Lys Tyr Tyr 4070 4075 4080 Val Met Leu Ala Lys Met Gly Pro Ile Val Arg Arg Ala Leu Leu 4085 4090 4095 Asn Ala Ile Glu Phe Gly Asn Leu Met Val Glu Lys Gly Tyr Val 4100 4105 4110 Gly Val Ile Thr Leu Asp Asn Gln Asp Leu Asn Gly Lys Phe Tyr 4115 4120 4125 Asp Phe Gly Asp Phe Gln Lys Thr Ala Pro Gly Ala Gly Val Pro 4130 4135 4140 Val Phe Asp Thr Tyr Tyr Ser Tyr Met Met Pro Ile Ile Ala Met 4145 4150 4155 Thr Asp Ala Leu Ala Pro Glu Arg Tyr Phe Glu Tyr Asp Val His 4160 4165 4170 Lys Gly Tyr Lys Ser Tyr Asp Leu Leu Lys Tyr Asp Tyr Thr Glu 4175 4180 4185 Glu Lys Gln Glu Leu Phe Gln Lys Tyr Phe Lys Tyr Trp Asp Gln 4190 4195 4200 Glu Tyr His Pro Asn Cys Arg Asp Cys Ser Asp Asp Arg Cys Leu 4205 4210 4215 Ile His Cys Ala Asn Phe Asn Ile Leu Phe Ser Thr Leu Ile Pro 4220 4225 4230 Gln Thr Ser Phe Gly Asn Leu Cys Arg Lys Val Phe Val Asp Gly 4235 4240 4245 Val Pro Phe Ile Ala Thr Cys Gly Tyr His Ser Lys Glu Leu Gly 4250 4255 4260 Val Ile Met Asn Gln Asp Asn Thr Met Ser Phe Ser Lys Met Gly 4265 4270 4275 Leu Ser Gln Leu Met Gln Phe Val Gly Asp Pro Ala Leu Leu Val 4280 4285 4290 Gly Thr Ser Asn Asn Leu Val Asp Leu Arg Thr Ser Cys Phe Ser 4295 4300 4305 Val Cys Ala Leu Thr Ser Gly Ile Thr His Gln Thr Val Lys Pro 4310 4315 4320 Gly His Phe Asn Lys Asp Phe Tyr Asp Phe Ala Glu Lys Ala Gly 4325 4330 4335 Met Phe Lys Glu Gly Ser Ser Ile Pro Leu Lys His Phe Phe Tyr 4340 4345 4350 Pro Gln Thr Gly Asn Ala Ala Ile Asn Asp Tyr Asp Tyr Tyr Arg 4355 4360 4365 Tyr Asn Arg Pro Thr Met Phe Asp Ile Cys Gln Leu Leu Phe Cys 4370 4375 4380 Leu Glu Val Thr Ser Lys Tyr Phe Glu Cys Tyr Glu Gly Gly Cys 4385 4390 4395 Ile Pro Ala Ser Gln Val Val Val Asn Asn Leu Asp Lys Ser Ala 4400 4405 4410 Gly Tyr Pro Phe Asn Lys Phe Gly Lys Ala Arg Leu Tyr Tyr Glu 4415 4420 4425 Met Ser Leu Glu Glu Gln Asp Gln Leu Phe Glu Ile Thr Lys Lys 4430 4435 4440 Asn Val Leu Pro Thr Ile Thr Gln Met Asn Leu Lys Tyr Ala Ile 4445 4450 4455 Ser Ala Lys Asn Arg Ala Arg Thr Val Ala Gly Val Ser Ile Leu 4460 4465 4470 Ser Thr Met Thr Asn Arg Gln Phe His Gln Lys Ile Leu Lys Ser 4475 4480 4485 Ile Val Asn Thr Arg Asn Ala Ser Val Val Ile Gly Thr Thr Lys 4490 4495 4500 Phe Tyr Gly Gly Trp Asp Asn Met Leu Arg Asn Leu Ile Gln Gly 4505 4510 4515 Val Glu Asp Pro Ile Leu Met Gly Trp Asp Tyr Pro Lys Cys Asp 4520 4525 4530 Arg Ala Met Pro Asn Leu Leu Arg Ile Ala Ala Ser Leu Val Leu 4535 4540 4545 Ala Arg Lys His Thr Asn Cys Cys Ser Trp Ser Glu Arg Ile Tyr 4550 4555 4560 Arg Leu Tyr Asn Glu Cys Ala Gln Val Leu Ser Glu Thr Val Leu 4565 4570 4575 Ala Thr Gly Gly Ile Tyr Val Lys Pro Gly Gly Thr Ser Ser Gly 4580 4585 4590 Asp Ala Thr Thr Ala Tyr Ala Asn Ser Val Phe Asn Ile Ile Gln 4595 4600 4605 Ala Thr Ser Ala Asn Val Ala Arg Leu Leu Ser Val Ile Thr Arg 4610 4615 4620 Asp Ile Val Tyr Asp Asn Ile Lys Ser Leu Gln Tyr Glu Leu Tyr 4625 4630 4635 Gln Gln Val Tyr Arg Arg Val Asn Phe Asp Pro Ala Phe Val Glu 4640 4645 4650 Lys Phe Tyr Ser Tyr Leu Cys Lys Asn Phe Ser Leu Met Ile Leu 4655 4660 4665 Ser Asp Asp Gly Val Val Cys Tyr Asn Asn Thr Leu Ala Lys Gln 4670 4675 4680 Gly Leu Val Ala Asp Ile Ser Gly Phe Arg Glu Val Leu Tyr Tyr 4685 4690 4695 Gln Asn Asn Val Phe Met Ala Asp Ser Lys Cys Trp Val Glu Pro 4700 4705 4710 Asp Leu Glu Lys Gly Pro His Glu Phe Cys Ser Gln His Thr Met 4715 4720 4725 Leu Val Glu Val Asp Gly Glu Pro Lys Tyr Leu Pro Tyr Pro Asp 4730 4735 4740 Pro Ser Arg Ile Leu Gly Ala Cys Val Phe Val Asp Asp Val Asp 4745 4750 4755 Lys Thr Glu Pro Val Ala Val Met Glu Arg Tyr Ile Ala Leu Ala 4760 4765 4770 Ile Asp Ala Tyr Pro Leu Val His His Glu Asn Glu Glu Tyr Lys 4775 4780 4785 Lys Val Phe Phe Val Leu Leu Ala Tyr Ile Arg Lys Leu Tyr Gln 4790 4795 4800 Glu Leu Ser Gln Asn Met Leu Met Asp Tyr Ser Phe Val Met Asp 4805 4810 4815 Ile Asp Lys Gly Ser Lys Phe Trp Glu Gln Glu Phe Tyr Glu Asn 4820 4825 4830 Met Tyr Arg Ala Pro Thr Thr Leu Gln Ser Cys Gly Val Cys Val 4835 4840 4845 Val Cys Asn Ser Gln Thr Ile Leu Arg Cys Gly Asn Cys Ile Arg 4850 4855 4860 Lys Pro Phe Leu Cys Cys Lys Cys Cys Tyr Asp His Val Met His 4865 4870 4875 Thr Asp His Lys Asn Val Leu Ser Ile Asn Pro Tyr Ile Cys Ser 4880 4885 4890 Gln Leu Gly Cys Gly Glu Ala Asp Val Thr Lys Leu Tyr Leu Gly 4895 4900 4905 Gly Met Ser Tyr Phe Cys Gly Asn His Lys Pro Lys Leu Ser Ile 4910 4915 4920 Pro Leu Val Ser Asn Gly Thr Val Phe Gly Ile Tyr Arg Ala Asn 4925 4930 4935 Cys Ala Gly Ser Glu Asn Val Asp Asp Phe Asn Gln Leu Ala Thr 4940 4945 4950 Thr Asn Trp Ser Ile Val Glu Pro Tyr Ile Leu Ala Asn Arg Cys 4955 4960 4965 Ser Asp Ser Leu Arg Arg Phe Ala Ala Glu Thr Val Lys Ala Thr 4970 4975 4980 Glu Glu Leu His Lys Gln Gln Phe Ala Ser Ala Glu Val Arg Glu 4985 4990 4995 Val Phe Ser Asp Arg Glu Leu Ile Leu Ser Trp Glu Pro Gly Lys 5000 5005 5010 Thr Arg Pro Pro Leu Asn Arg Asn Tyr Val Phe Thr Gly Tyr His 5015 5020 5025 Phe Thr Arg Thr Ser Lys Val Gln Leu Gly Asp Phe Thr Phe Glu 5030 5035 5040 Lys Gly Glu Gly Lys Asp Val Val Tyr Tyr Lys Ala Thr Ser Thr 5045 5050 5055 Ala Lys Leu Ser Val Gly Asp Ile Phe Val Leu Thr Ser His Asn 5060 5065 5070 Val Val Ser Leu Val Ala Pro Thr Leu Cys Pro Gln Gln Thr Phe 5075 5080 5085 Ser Arg Phe Val Asn Leu Arg Pro Asn Val Met Val Pro Glu Cys 5090 5095 5100 Phe Val Asn Asn Ile Pro Leu Tyr His Leu Val Gly Lys Gln Lys 5105 5110 5115 Arg Thr Thr Val Gln Gly Pro Pro Gly Ser Gly Lys Ser His Phe 5120 5125 5130 Ala Ile Gly Leu Ala Val Tyr Phe Ser Ser Ala Arg Val Val Phe 5135 5140 5145 Thr Ala Cys Ser His Ala Ala Val Asp Ala Leu Cys Glu Lys Ala 5150 5155 5160 Phe Lys Phe Leu Lys Val Asp Asp Cys Thr Arg Ile Val Pro Gln 5165 5170 5175 Arg Thr Thr Val Asp Cys Phe Ser Lys Phe Lys Ala Asn Asp Thr 5180 5185 5190 Gly Lys Lys Tyr Ile Phe Ser Thr Ile Asn Ala Leu Pro Glu Val 5195 5200 5205 Ser Cys Asp Ile Leu Leu Val Asp Glu Val Ser Met Leu Thr Asn 5210 5215 5220 Tyr Glu Leu Ser Phe Ile Asn Gly Lys Ile Asn Tyr Gln Tyr Val 5225 5230 5235 Val Tyr Val Gly Asp Pro Ala Gln Leu Pro Ala Pro Arg Thr Leu 5240 5245 5250 Leu Asn Gly Ser Leu Ser Pro Lys Asp Tyr Asn Val Val Thr Asn 5255 5260 5265 Leu Met Val Cys Val Lys Pro Asp Ile Phe Leu Ala Lys Cys Tyr 5270 5275 5280 Arg Cys Pro Lys Glu Ile Val Asp Thr Val Ser Thr Leu Val Tyr 5285 5290 5295 Asp Gly Lys Phe Ile Ala Asn Asn Pro Glu Ser Arg Glu Cys Phe 5300 5305 5310 Lys Val Ile Val Asn Asn Gly Asn Ser Asp Val Gly His Glu Ser 5315 5320 5325 Gly Ser Ala Tyr Asn Thr Thr Gln Leu Glu Phe Val Lys Asp Phe 5330 5335 5340 Val Cys Arg Asn Lys Gln Trp Arg Glu Ala Ile Phe Ile Ser Pro 5345 5350 5355 Tyr Asn Ala Met Asn Gln Arg Ala Tyr Arg Met Leu Gly Leu Asn 5360 5365 5370 Val Gln Thr Val Asp Ser Ser Gln Gly Ser Glu Tyr Asp Tyr Val 5375 5380 5385 Ile Phe Cys Val Thr Ala Asp Ser Gln His Ala Leu Asn Ile Asn 5390 5395 5400 Arg Phe Asn Val Ala Leu Thr Arg Ala Lys Arg Gly Ile Leu Val 5405 5410 5415 Val Met Arg Gln Arg Asp Glu Leu Tyr Ser Ala Leu Lys Phe Thr 5420 5425 5430 Glu Leu Asp Ser Glu Thr Ser Leu Gln Gly Thr Gly Leu Phe Lys 5435 5440 5445 Ile Cys Asn Lys Glu Phe Ser Gly Val His Pro Ala Tyr Ala Val 5450 5455 5460 Thr Thr Lys Ala Leu Ala Ala Thr Tyr Lys Val Asn Asp Glu Leu 5465 5470 5475 Ala Ala Leu Val Asn Val Glu Ala Gly Ser Glu Ile Thr Tyr Lys 5480 5485 5490 His Leu Ile Ser Leu Leu Gly Phe Lys Met Ser Val Asn Val Glu 5495 5500 5505 Gly Cys His Asn Met Phe Ile Thr Arg Asp Glu Ala Ile Arg Asn 5510 5515 5520 Val Arg Gly Trp Val Gly Phe Asp Val Glu Ala Thr His Ala Cys 5525 5530 5535 Gly Thr Asn Ile Gly Thr Asn Leu Pro Phe Gln Val Gly Phe Ser 5540 5545 5550 Thr Gly Ala Asp Phe Val Val Thr Pro Glu Gly Leu Val Asp Thr 5555 5560 5565 Ser Ile Gly Asn Asn Phe Glu Pro Val Asn Ser Lys Ala Pro Pro 5570 5575 5580 Gly Glu Gln Phe Asn His Leu Arg Val Leu Phe Lys Ser Ala Lys 5585 5590 5595 Pro Trp His Val Ile Arg Pro Arg Ile Val Gln Met Leu Ala Asp 5600 5605 5610 Asn Leu Cys Asn Val Ser Asp Cys Val Val Phe Val Thr Trp Cys 5615 5620 5625 His Gly Leu Glu Leu Thr Thr Leu Arg Tyr Phe Val Lys Ile Gly 5630 5635 5640 Lys Glu Gln Val Cys Ser Cys Gly Ser Arg Ala Thr Thr Phe Asn 5645 5650 5655 Ser His Thr Gln Ala Tyr Ala Cys Trp Lys His Cys Leu Gly Phe 5660 5665 5670 Asp Phe Val Tyr Asn Pro Leu Leu Val Asp Ile Gln Gln Trp Gly 5675 5680 5685 Tyr Ser Gly Asn Leu Gln Phe Asn His Asp Leu His Cys Asn Val 5690 5695 5700 His Gly His Ala His Val Ala Ser Val Asp Ala Ile Met Thr Arg 5705 5710 5715 Cys Leu Ala Ile Asn Asn Ala Phe Cys Gln Asp Val Asn Trp Asp 5720 5725 5730 Leu Thr Tyr Pro His Ile Ala Asn Glu Asp Glu Val Asn Ser Ser 5735 5740 5745 Cys Arg Tyr Leu Gln Arg Met Tyr Leu Asn Ala Cys Val Asp Ala 5750 5755 5760 Leu Lys Val Asn Val Val Tyr Asp Ile Gly Asn Pro Lys Gly Ile 5765 5770 5775 Lys Cys Val Arg Arg Gly Asp Val Asn Phe Arg Phe Tyr Asp Lys 5780 5785 5790 Asn Pro Ile Val Arg Asn Val Lys Gln Phe Glu Tyr Asp Tyr Asn 5795 5800 5805 Gln His Lys Asp Lys Phe Ala Asp Gly Leu Cys Met Phe Trp Asn 5810 5815 5820 Cys Asn Val Asp Cys Tyr Pro Asp Asn Ser Leu Val Cys Arg Tyr 5825 5830 5835 Asp Thr Arg Asn Leu Ser Val Phe Asn Leu Pro Gly Cys Asn Gly 5840 5845 5850 Gly Ser Leu Tyr Val Asn Lys His Ala Phe Tyr Thr Pro Lys Phe 5855 5860 5865 Asp Arg Ile Ser Phe Arg Asn Leu Lys Ala Met Pro Phe Phe Phe 5870 5875 5880 Tyr Asp Ser Ser Pro Cys Glu Thr Ile Gln Val Asp Gly Val Ala 5885 5890 5895 Gln Asp Leu Val Ser Leu Ala Thr Lys Asp Cys Ile Thr Lys Cys 5900 5905 5910 Asn Ile Gly Gly Ala Val Cys Lys Lys His Ala Gln Met Tyr Ala 5915 5920 5925 Glu Phe Val Thr Ser Tyr Asn Ala Ala Val Thr Ala Gly Phe Thr 5930 5935 5940 Phe Trp Val Thr Asn Lys Leu Asn Pro Tyr Asn Leu Trp Lys Ser 5945 5950 5955 Phe Ser Ala Leu Gln Ser Ile Asp Asn Ile Ala Tyr Asn Met Tyr 5960 5965 5970 Lys Gly Gly His Tyr Asp Ala Ile Ala Gly Glu Met Pro Thr Val 5975 5980 5985 Ile Thr Gly Asp Lys Val Phe Val Ile Asp Gln Gly Val Glu Lys 5990 5995 6000 Ala Val Phe Val Asn Gln Thr Thr Leu Pro Thr Ser Val Ala Phe 6005 6010 6015 Glu Leu Tyr Ala Lys Arg Asn Ile Arg Thr Leu Pro Asn Asn Arg 6020 6025 6030 Ile Leu Lys Gly Leu Gly Val Asp Val Thr Asn Gly Phe Val Ile 6035 6040 6045 Trp Asp Tyr Ala Asn Gln Thr Pro Leu Tyr Arg Asn Thr Val Lys 6050 6055 6060 Val Cys Ala Tyr Thr Asp Ile Glu Pro Asn Gly Leu Val Val Leu 6065 6070 6075 Tyr Asp Asp Arg Tyr Gly Asp Tyr Gln Ser Phe Leu Ala Ala Asp 6080 6085 6090 Asn Ala Val Leu Val Ser Thr Gln Cys Tyr Lys Arg Tyr Ser Tyr 6095 6100 6105 Val Glu Ile Pro Ser Asn Leu Leu Val Gln Asn Gly Met Pro Leu 6110 6115 6120 Lys Asp Gly Ala Asn Leu Tyr Val Tyr Lys Arg Val Asn Gly Ala 6125 6130 6135 Phe Val Thr Leu Pro Asn Thr Ile Asn Thr Gln Gly Arg Ser Tyr 6140 6145 6150 Glu Thr Phe Glu Pro Arg Ser Asp Ile Glu Arg Asp Phe Leu Ala 6155 6160 6165 Met Ser Glu Glu Ser Phe Val Glu Arg Tyr Gly Lys Asp Leu Gly 6170 6175 6180 Leu Gln His Ile Leu Tyr Gly Glu Val Asp Lys Pro Gln Leu Gly 6185 6190 6195 Gly Leu His Thr Val Ile Gly Met Tyr Arg Leu Leu Arg Ala Asn 6200 6205 6210 Lys Leu Asn Ala Lys Ser Val Thr Asn Ser Asp Ser Asp Val Met 6215 6220 6225 Gln Asn Tyr Phe Val Leu Ser Asp Asn Gly Ser Tyr Lys Gln Val 6230 6235 6240 Cys Thr Val Val Asp Leu Leu Leu Asp Asp Phe Leu Glu Leu Leu 6245 6250 6255 Arg Asn Ile Leu Lys Glu Tyr Gly Thr Asn Lys Ser Lys Val Val 6260 6265 6270 Thr Val Ser Ile Asp Tyr His Ser Ile Asn Phe Met Thr Trp Phe 6275 6280 6285 Glu Asp Gly Ser Ile Lys Thr Cys Tyr Pro Gln Leu Gln Ser Ala 6290 6295 6300 Trp Thr Cys Gly Tyr Asn Met Pro Glu Leu Tyr Lys Val Gln Asn 6305 6310 6315 Cys Val Met Glu Pro Cys Asn Ile Pro Asn Tyr Gly Val Gly Ile 6320 6325 6330 Thr Leu Pro Ser Gly Ile Leu Met Asn Val Ala Lys Tyr Thr Gln 6335 6340 6345 Leu Cys Gln Tyr Leu Ser Lys Thr Thr Ile Cys Val Pro His Asn 6350 6355 6360 Met Arg Val Met His Phe Gly Ala Gly Ser Asp Lys Gly Val Ala 6365 6370 6375 Pro Gly Ser Thr Val Leu Lys Gln Trp Leu Pro Glu Gly Thr Leu 6380 6385 6390 Leu Val Asp Asn Asp Ile Val Asp Tyr Val Ser Asp Ala His Val 6395 6400 6405 Ser Val Leu Ser Asp Cys Asn Lys Tyr Asn Thr Glu His Lys Phe 6410 6415 6420 Asp Leu Val Ile Ser Asp Met Tyr Thr Asp Asn Asp Ser Lys Arg 6425 6430 6435 Lys His Glu Gly Val Ile Ala Asn Asn Gly Asn Asp Asp Val Phe 6440 6445 6450 Ile Tyr Leu Ser Ser Phe Leu Arg Asn Asn Leu Ala Leu Gly Gly 6455 6460 6465 Ser Phe Ala Val Lys Val Thr Glu Thr Ser Trp His Glu Val Leu 6470 6475 6480 Tyr Asp Ile Ala Gln Asp Cys Ala Trp Trp Thr Met Phe Cys Thr 6485 6490 6495 Ala Val Asn Ala Ser Ser Ser Glu Ala Phe Leu Ile Gly Val Asn 6500 6505 6510 Tyr Leu Gly Ala Ser Glu Lys Val Lys Val Ser Gly Lys Thr Leu 6515 6520 6525 His Ala Asn Tyr Ile Phe Trp Arg Asn Cys Asn Tyr Leu Gln Thr 6530 6535 6540 Ser Ala Tyr Ser Ile Phe Asp Val Ala Lys Phe Asp Leu Arg Leu 6545 6550 6555 Lys Ala Thr Pro Val Val Asn Leu Lys Thr Glu Gln Lys Thr Asp 6560 6565 6570 Leu Val Phe Asn Leu Ile Lys Cys Gly Lys Leu Leu Val Arg Asp 6575 6580 6585 Val Gly Asn Thr Ser Phe Thr Ser Asp Ser Phe Val Cys Thr Met 6590 6595 6600 <210> 22 <211> 7058 <212> PRT <213> Bovine Coronavirus <220> <221> MISC_FEATURE <223> ORF 1AB <400> 22 Met Ser Lys Ile Asn Lys Tyr Gly Leu Glu Leu His Trp Ala Pro Glu 1 5 10 15 Phe Pro Trp Met Phe Glu Asp Ala Glu Glu Lys Leu Asp Asn Pro Ser 20 25 30 Ser Ser Glu Val Asp Ile Val Cys Ser Thr Thr Ala Gln Lys Leu Glu 35 40 45 Thr Gly Gly Ile Cys Pro Glu Asn His Val Met Val Asp Cys Arg Arg 50 55 60 Leu Leu Lys Gln Glu Cys Cys Val Gln Ser Ser Leu Ile Arg Glu Ile 65 70 75 80 Val Met Asn Thr Arg Pro Tyr Asp Leu Glu Val Leu Leu Gln Asp Ala 85 90 95 Leu Gln Ser Arg Glu Ala Val Leu Val Thr Pro Pro Leu Gly Met Ser 100 105 110 Leu Glu Ala Cys Tyr Val Arg Gly Cys Asn Pro Asn Gly Trp Thr Met 115 120 125 Gly Leu Phe Arg Arg Arg Ser Val Cys Asn Thr Gly Arg Cys Ala Val 130 135 140 Asn Lys His Val Ala Tyr Gln Leu Tyr Met Ile Asp Pro Ala Gly Val 145 150 155 160 Cys Phe Gly Ala Gly Gln Phe Val Gly Trp Val Ile Pro Leu Ala Phe 165 170 175 Met Pro Val Gln Ser Arg Lys Phe Ile Ala Pro Trp Val Met Tyr Leu 180 185 190 Arg Lys Cys Gly Glu Lys Gly Ala Tyr Ile Lys Asp Tyr Lys Arg Gly 195 200 205 Gly Phe Glu His Val Tyr Asn Phe Lys Val Glu Asp Ala Tyr Asp Leu 210 215 220 Val His Asp Glu Pro Lys Gly Lys Phe Ser Lys Lys Ala Tyr Ala Leu 225 230 235 240 Ile Arg Gly Tyr Arg Gly Val Lys Pro Leu Leu Tyr Val Asp Gln Tyr 245 250 255 Gly Cys Asp Tyr Thr Gly Gly Leu Ala Asp Gly Leu Glu Ala Tyr Ala 260 265 270 Asp Lys Thr Leu Gln Glu Met Lys Ala Leu Phe Pro Ile Trp Ser Gln 275 280 285 Glu Leu Pro Phe Asp Val Thr Val Ala Trp His Val Val Arg Asp Pro 290 295 300 Arg Tyr Val Met Arg Leu Gln Ser Ala Ser Thr Ile Arg Ser Val Ala 305 310 315 320 Tyr Val Ala Asn Pro Thr Glu Asp Leu Cys Asp Gly Ser Val Val Ile 325 330 335 Lys Glu Pro Val His Val Tyr Ala Asp Asp Ser Ile Ile Leu Arg Gln 340 345 350 His Asn Leu Val Asp Ile Met Ser Cys Phe Tyr Met Glu Ala Asp Ala 355 360 365 Val Val Asn Ala Phe Tyr Gly Val Asp Leu Lys Asp Cys Gly Phe Val 370 375 380 Met Gln Phe Gly Tyr Ile Asp Cys Glu Gln Asp Leu Cys Asp Phe Lys 385 390 395 400 Gly Trp Val Pro Gly Asn Met Ile Asp Gly Phe Ala Cys Thr Thr Cys 405 410 415 Gly His Val Tyr Glu Thr Gly Asp Leu Leu Ala Gln Ser Ser Gly Val 420 425 430 Leu Pro Val Asn Pro Val Leu His Thr Lys Ser Ala Ala Gly Tyr Gly 435 440 445 Gly Phe Gly Cys Lys Asp Ser Phe Thr Leu Tyr Gly Gln Thr Val Val 450 455 460 Tyr Phe Gly Gly Cys Val Tyr Trp Ser Pro Ala Arg Asn Ile Trp Ile 465 470 475 480 Pro Ile Leu Lys Ser Ser Val Lys Ser Tyr Asp Gly Leu Val Tyr Thr 485 490 495 Gly Val Val Gly Cys Lys Ala Ile Val Lys Glu Thr Asn Leu Ile Cys 500 505 510 Lys Ala Leu Tyr Leu Asp Tyr Val Gln His Lys Cys Gly Asn Leu His 515 520 525 Gln Arg Glu Leu Leu Gly Val Ser Asp Val Trp His Lys Gln Leu Leu 530 535 540 Leu Asn Arg Gly Val Tyr Lys Pro Leu Leu Glu Asn Ile Asp Tyr Phe 545 550 555 560 Asn Met Arg Arg Ala Lys Phe Ser Leu Glu Thr Phe Thr Val Cys Ala 565 570 575 Asp Gly Phe Met Pro Phe Leu Leu Asp Asp Leu Val Pro Arg Ala Tyr 580 585 590 Tyr Leu Ala Val Ser Gly Gln Ala Phe Cys Asp Tyr Ala Gly Lys Ile 595 600 605 Cys His Ala Val Val Ser Lys Ser Lys Glu Leu Leu Asp Val Ser Val 610 615 620 Asp Ser Leu Gly Ala Ala Ile His Tyr Leu Asn Ser Lys Ile Val Asp 625 630 635 640 Leu Ala Gln His Phe Ser Asp Phe Gly Thr Ser Phe Val Ser Lys Ile 645 650 655 Val His Phe Phe Lys Thr Phe Thr Thr Ser Thr Ala Leu Ala Phe Ala 660 665 670 Trp Val Leu Phe His Val Leu His Gly Ala Tyr Ile Val Val Glu Ser 675 680 685 Asp Ile Tyr Phe Gly Lys Asn Ile Pro Arg Tyr Ala Ser Ala Val Ala 690 695 700 Gln Ala Phe Arg Ser Gly Ala Lys Val Gly Leu Asp Ser Leu Arg Val 705 710 715 720 Thr Phe Ile Asp Gly Leu Ser Cys Phe Lys Ile Gly Arg Arg Arg Ile 725 730 735 Cys Leu Ser Gly Ser Lys Ile Tyr Glu Val Glu Arg Gly Leu Leu His 740 745 750 Ser Ser Gln Leu Pro Leu Asp Val Tyr Asp Leu Thr Met Pro Ser Gln 755 760 765 Val Gln Lys Thr Lys Gln Lys Gly Ile Tyr Leu Lys Gly Ser Gly Ser 770 775 780 Asp Phe Ser Leu Ala Asp Ser Val Val Glu Val Val Thr Thr Ser Leu 785 790 795 800 Thr Pro Cys Gly Tyr Ser Glu Pro Pro Lys Val Ala Asp Lys Ile Cys 805 810 815 Ile Val Asp Asn Val Tyr Met Ala Lys Ala Gly Asp Lys Tyr Tyr Pro 820 825 830 Val Val Val Asp Gly His Val Gly Leu Leu Asp Gln Ala Trp Arg Val 835 840 845 Pro Cys Ala Gly Arg Cys Val Thr Phe Lys Glu Gln Pro Thr Val Asn 850 855 860 Glu Ile Ala Ser Thr Pro Lys Thr Ile Lys Val Phe Tyr Glu Leu Asp 865 870 875 880 Lys Asp Phe Asn Thr Ile Leu Asn Thr Ala Cys Gly Glu Phe Glu Val 885 890 895 Asp Asp Thr Val Asp Met Glu Glu Phe Tyr Ala Val Val Ile Asp Ala 900 905 910 Ile Glu Glu Lys Leu Ser Pro Cys Lys Glu Leu Glu Gly Val Gly Ala 915 920 925 Lys Val Ser Ala Phe Leu Gln Lys Leu Glu Asp Asn Ser Leu Phe Leu 930 935 940 Phe Asp Glu Ala Gly Glu Glu Val Leu Ala Pro Lys Leu Tyr Cys Ala 945 950 955 960 Phe Thr Ala Pro Glu Asp Asp Asp Phe Leu Glu Glu Ser Gly Val Glu 965 970 975 Glu Asp Asp Val Glu Gly Glu Glu Thr Asp Leu Thr Val Thr Ser Ala 980 985 990 Gly Glu Pro Cys Val Ala Ser Glu Gln Glu Glu Ser Ser Glu Ile Leu 995 1000 1005 Glu Asp Thr Leu Asp Asp Gly Pro Cys Val Glu Thr Ser Asp Ser 1010 1015 1020 Gln Val Glu Glu Asp Val Gln Met Ser Asp Phe Gly Asp Leu Glu 1025 1030 1035 Ser Val Ile Gln Asp Tyr Glu Asn Val Cys Phe Glu Phe Tyr Thr 1040 1045 1050 Thr Glu Pro Glu Phe Val Lys Val Leu Asp Leu Tyr Val Pro Lys 1055 1060 1065 Ala Thr Arg Asn Asn Cys Trp Leu Arg Ser Val Leu Ala Val Met 1070 1075 1080 Gln Lys Leu Pro Cys Gln Phe Lys Asp Lys Asn Leu Gln Asp Leu 1085 1090 1095 Trp Val Leu Tyr Lys Gln Gln Tyr Ser Gln Leu Phe Val Asp Thr 1100 1105 1110 Leu Val Asn Lys Ile Pro Ala Asn Ile Val Val Pro Gln Gly Gly 1115 1120 1125 Tyr Val Ala Asp Phe Ala Tyr Trp Phe Leu Thr Leu Cys Asp Trp 1130 1135 1140 Gln Cys Val Ala Tyr Trp Lys Cys Ile Lys Cys Asp Leu Ala Leu 1145 1150 1155 Lys Leu Lys Gly Leu Asp Ala Met Phe Phe Tyr Gly Asp Val Val 1160 1165 1170 Ser His Val Cys Lys Cys Gly Glu Ser Met Val Leu Ile Asp Val 1175 1180 1185 Asp Val Pro Phe Thr Ala His Phe Ala Leu Lys Asp Lys Leu Phe 1190 1195 1200 Cys Ala Phe Ile Thr Lys Arg Ser Val Tyr Lys Ala Ala Cys Val 1205 1210 1215 Val Asp Val Asn Asp Ser His Ser Met Ala Val Val Asp Gly Lys 1220 1225 1230 Gln Ile Asp Asp His Arg Ile Thr Ser Ile Thr Ser Asp Lys Phe 1235 1240 1245 Asp Phe Ile Ile Gly His Gly Thr Ser Phe Ser Met Thr Thr Phe 1250 1255 1260 Glu Ile Ala Gln Leu Tyr Gly Ser Cys Ile Thr Pro Asn Val Cys 1265 1270 1275 Phe Val Lys Gly Asp Ile Ile Lys Val Ser Lys Arg Val Lys Ala 1280 1285 1290 Glu Val Val Val Asn Pro Ala Asn Gly His Met Ala His Gly Gly 1295 1300 1305 Gly Val Ala Lys Ala Ile Ala Val Ala Ala Gly Gln Gln Phe Val 1310 1315 1320 Lys Glu Thr Thr Asp Met Val Lys Ser Lys Gly Val Cys Ala Thr 1325 1330 1335 Gly Asp Cys Tyr Val Ser Thr Gly Gly Lys Leu Cys Lys Thr Val 1340 1345 1350 Leu Asn Val Val Gly Pro Asp Ala Arg Thr Gln Gly Lys Gln Ser 1355 1360 1365 Tyr Ala Leu Leu Glu Arg Val Tyr Lys His Leu Asn Lys Tyr Asp 1370 1375 1380 Cys Val Val Thr Thr Leu Ile Ser Ala Gly Ile Phe Ser Val Pro 1385 1390 1395 Ser Asp Val Ser Leu Thr Tyr Leu Leu Gly Thr Ala Lys Lys Gln 1400 1405 1410 Val Val Leu Val Ser Asn Asn Gln Glu Asp Phe Asp Leu Ile Ser 1415 1420 1425 Lys Cys Gln Ile Thr Ala Val Glu Gly Thr Lys Lys Leu Ala Glu 1430 1435 1440 Arg Leu Ser Phe Asn Val Gly Arg Ser Ile Val Tyr Glu Thr Asp 1445 1450 1455 Ala Asn Lys Leu Ile Leu Ser Asn Asp Val Ala Phe Val Ser Thr 1460 1465 1470 Phe Asn Val Leu Gln Asp Val Leu Ser Leu Arg His Asp Ile Ala 1475 1480 1485 Leu Asp Asp Asp Ala Arg Thr Phe Val Gln Ser Asn Val Asp Val 1490 1495 1500 Val Pro Glu Gly Trp Arg Val Val Asn Lys Phe Tyr Gln Ile Asn 1505 1510 1515 Gly Val Arg Pro Val Lys Tyr Phe Glu Cys Pro Gly Gly Ile Asp 1520 1525 1530 Ile Cys Ser Gln Asp Lys Val Phe Gly Tyr Val Gln Gln Gly Ser 1535 1540 1545 Phe Asn Lys Ala Thr Val Ala Gln Ile Lys Ala Leu Phe Leu Asp 1550 1555 1560 Lys Val Asp Ile Leu Leu Thr Val Asp Gly Val Asn Phe Thr Asn 1565 1570 1575 Arg Phe Val Pro Val Gly Glu Ser Phe Gly Lys Ser Leu Gly Asn 1580 1585 1590 Val Phe Cys Asp Gly Val Asn Val Thr Lys His Lys Cys Asp Ile 1595 1600 1605 Asn Tyr Lys Gly Lys Val Phe Phe Gln Phe Asp Asn Leu Ser Ser 1610 1615 1620 Glu Asp Leu Lys Ala Val Arg Ser Ser Phe Asn Phe Asp Gln Lys 1625 1630 1635 Glu Leu Leu Ala Tyr Tyr Asn Met Leu Val Asn Cys Ser Lys Trp 1640 1645 1650 Gln Val Val Phe Asn Gly Lys Tyr Phe Thr Phe Lys Gln Ala Asn 1655 1660 1665 Asn Asn Cys Phe Val Asn Val Ser Cys Leu Met Leu Gln Ser Leu 1670 1675 1680 Asn Leu Lys Phe Lys Ile Val Gln Trp Gln Glu Ala Trp Leu Glu 1685 1690 1695 Phe Arg Ser Gly Arg Pro Ala Arg Phe Val Ser Leu Val Leu Ala 1700 1705 1710 Lys Gly Gly Phe Lys Phe Gly Asp Pro Ala Asp Ser Arg Asp Phe 1715 1720 1725 Leu Arg Val Val Phe Ser Gln Val Asp Leu Thr Gly Ala Ile Cys 1730 1735 1740 Asp Phe Glu Ile Ala Cys Lys Cys Gly Val Lys Gln Glu Gln Arg 1745 1750 1755 Thr Gly Val Asp Ala Val Met His Phe Gly Thr Leu Ser Arg Glu 1760 1765 1770 Asp Leu Glu Ile Gly Tyr Thr Val Asp Cys Ser Cys Gly Lys Lys 1775 1780 1785 Leu Ile His Cys Val Arg Phe Asp Val Pro Phe Leu Ile Cys Ser 1790 1795 1800 Asn Thr Pro Ala Ser Val Lys Leu Pro Lys Gly Val Gly Ser Ala 1805 1810 1815 Asn Ile Phe Lys Gly Asp Lys Val Gly His Tyr Val His Val Lys 1820 1825 1830 Cys Glu Gln Ser Tyr Gln Leu Tyr Asp Ala Ser Asn Val Lys Lys 1835 1840 1845 Val Thr Asp Val Thr Gly Asn Leu Ser Asp Cys Leu Tyr Leu Lys 1850 1855 1860 Asn Leu Lys Gln Thr Phe Lys Ser Val Leu Thr Thr Tyr Tyr Leu 1865 1870 1875 Asp Asp Val Lys Lys Ile Glu Tyr Lys Pro Asp Leu Ser Gln Tyr 1880 1885 1890 Tyr Cys Asp Gly Gly Lys Tyr Tyr Thr Gln Arg Ile Ile Lys Ala 1895 1900 1905 Gln Phe Lys Thr Phe Glu Lys Val Asp Gly Val Tyr Thr Asn Phe 1910 1915 1920 Lys Leu Ile Gly His Thr Val Cys Asp Ile Leu Asn Ala Lys Leu 1925 1930 1935 Gly Phe Asp Ser Ser Lys Glu Phe Val Glu Tyr Lys Val Thr Glu 1940 1945 1950 Trp Pro Thr Ala Thr Gly Asp Val Val Leu Ala Thr Asp Asp Leu 1955 1960 1965 Tyr Val Lys Arg Tyr Glu Arg Gly Cys Ile Thr Phe Gly Lys Pro 1970 1975 1980 Val Ile Trp Leu Ser His Glu Gln Ala Ser Leu Asn Ser Leu Thr 1985 1990 1995 Tyr Phe Asn Arg Pro Leu Leu Val Asp Glu Asn Lys Phe Asp Val 2000 2005 2010 Leu Lys Val Asp Asp Val Asp Asp Gly Gly Asp Ile Ser Glu Ser 2015 2020 2025 Asp Ala Lys Glu Pro Lys Glu Ile Asn Ile Ile Lys Leu Ser Gly 2030 2035 2040 Val Lys Lys Pro Phe Lys Val Glu Asp Ser Val Ile Val Asn Asp 2045 2050 2055 Asp Thr Ser Glu Ile Lys Tyr Val Lys Ser Leu Ser Ile Val Asp 2060 2065 2070 Val Tyr Asp Met Trp Leu Thr Gly Cys Arg Cys Val Val Arg Thr 2075 2080 2085 Ala Asn Ala Leu Ser Arg Ala Val Asn Val Pro Thr Ile Arg Lys 2090 2095 2100 Phe Ile Lys Phe Gly Met Thr Leu Val Ser Ile Pro Ile Asp Leu 2105 2110 2115 Leu Asn Leu Arg Glu Ile Lys Pro Val Phe Asn Val Val Lys Ala 2120 2125 2130 Val Arg Asn Lys Ile Ser Ala Cys Phe Asn Phe Ile Lys Trp Leu 2135 2140 2145 Phe Val Leu Leu Phe Gly Trp Ile Lys Ile Ser Ala Asp Asn Lys 2150 2155 2160 Val Ile Tyr Thr Thr Glu Val Ala Ser Lys Leu Thr Cys Lys Leu 2165 2170 2175 Val Ala Leu Ala Phe Lys Asn Ala Phe Leu Thr Phe Lys Trp Ser 2180 2185 2190 Val Val Ala Arg Gly Ala Cys Ile Ile Ala Thr Ile Phe Leu Leu 2195 2200 2205 Trp Phe Asn Phe Ile Tyr Ala Asn Val Ile Phe Ser Asp Phe Tyr 2210 2215 2220 Leu Pro Lys Ile Gly Phe Leu Pro Thr Phe Val Gly Lys Ile Val 2225 2230 2235 Gln Trp Ile Lys Asn Thr Phe Ser Leu Val Thr Ile Cys Asp Leu 2240 2245 2250 Tyr Ser Ile Gln Asp Val Gly Phe Lys Asn Gln Tyr Cys Asn Gly 2255 2260 2265 Ser Ile Ala Cys Gln Phe Cys Leu Ala Gly Phe Asp Met Leu Asp 2270 2275 2280 Asn Tyr Lys Ala Ile Asp Val Val Gln Tyr Glu Ala Asp Arg Arg 2285 2290 2295 Ala Phe Val Asp Tyr Thr Gly Val Leu Lys Ile Val Ile Glu Leu 2300 2305 2310 Ile Val Ser Tyr Ala Leu Tyr Thr Ala Trp Phe Tyr Pro Leu Phe 2315 2320 2325 Ala Leu Ile Ser Ile Gln Ile Leu Thr Thr Trp Leu Pro Glu Leu 2330 2335 2340 Leu Met Leu Ser Thr Leu His Trp Ser Val Arg Leu Leu Val Ser 2345 2350 2355 Leu Ala Asn Met Leu Pro Ala His Val Phe Met Arg Phe Tyr Ile 2360 2365 2370 Ile Ile Ala Ser Phe Ile Lys Leu Phe Ser Leu Phe Arg His Val 2375 2380 2385 Ala Tyr Gly Cys Ser Lys Ser Gly Cys Leu Phe Cys Tyr Lys Arg 2390 2395 2400 Asn Arg Ser Leu Arg Val Lys Cys Ser Thr Ile Val Gly Gly Met 2405 2410 2415 Ile Arg Tyr Tyr Asp Val Met Ala Asn Gly Gly Thr Gly Phe Cys 2420 2425 2430 Ser Lys His Gln Trp Asn Cys Ile Asp Cys Asp Ser Tyr Lys Pro 2435 2440 2445 Gly Asn Thr Phe Ile Thr Val Glu Ala Ala Leu Asp Leu Ser Lys 2450 2455 2460 Glu Leu Lys Arg Pro Ile Gln Pro Thr Asp Val Ala Tyr His Thr 2465 2470 2475 Val Thr Asp Val Lys Gln Val Gly Cys Tyr Met Arg Leu Phe Tyr 2480 2485 2490 Asp Arg Asp Gly Gln Arg Thr Tyr Asp Asp Val Asn Ala Ser Leu 2495 2500 2505 Phe Val Asp Tyr Ser Asn Leu Leu His Ser Lys Val Lys Ser Val 2510 2515 2520 Pro Asn Met His Val Val Val Val Glu Asn Asp Ala Asp Lys Ala 2525 2530 2535 Asn Phe Leu Asn Ala Ala Val Phe Tyr Ala Gln Ser Leu Phe Arg 2540 2545 2550 Pro Ile Leu Met Val Asp Lys Ile Leu Ile Thr Thr Ala Asn Thr 2555 2560 2565 Gly Thr Ser Val Thr Glu Thr Met Phe Asp Val Tyr Val Asp Thr 2570 2575 2580 Phe Leu Ser Met Phe Asp Val Asp Lys Lys Ser Leu Asn Ala Leu 2585 2590 2595 Ile Ala Thr Ala His Ser Ser Ile Lys Gln Gly Thr Gln Ile Cys 2600 2605 2610 Lys Val Leu Asp Thr Phe Leu Ser Cys Ala Arg Lys Ser Cys Ser 2615 2620 2625 Ile Asp Ser Asp Val Asp Thr Lys Cys Leu Ala Asp Ser Val Met 2630 2635 2640 Ser Ala Val Ser Ala Gly Leu Glu Leu Thr Asp Glu Ser Cys Asn 2645 2650 2655 Asn Leu Val Pro Thr Tyr Leu Lys Gly Asp Asn Ile Val Ala Ala 2660 2665 2670 Asp Leu Gly Val Leu Ile Gln Asn Ser Ala Lys His Val Gln Gly 2675 2680 2685 Asn Val Ala Lys Ile Ala Gly Val Ser Cys Ile Trp Ser Val Asp 2690 2695 2700 Ala Phe Asn Gln Leu Ser Ser Asp Phe Gln His Lys Leu Lys Lys 2705 2710 2715 Ala Cys Cys Lys Thr Gly Leu Lys Leu Glu Leu Thr Tyr Asn Lys 2720 2725 2730 Gln Met Ala Asn Val Ser Val Leu Thr Thr Pro Phe Ser Leu Lys 2735 2740 2745 Gly Gly Ala Val Phe Ser Tyr Phe Val Tyr Val Cys Phe Val Leu 2750 2755 2760 Ser Leu Val Cys Phe Ile Gly Leu Trp Cys Leu Met Pro Thr Tyr 2765 2770 2775 Thr Val His Lys Ser Asp Phe Gln Leu Pro Val Tyr Ala Ser Tyr 2780 2785 2790 Lys Val Leu Asp Asn Gly Val Ile Arg Asp Val Ser Val Glu Asp 2795 2800 2805 Val Cys Phe Ala Asn Lys Phe Glu Gln Phe Asp Gln Trp Tyr Glu 2810 2815 2820 Ser Thr Phe Gly Leu Ser Tyr Tyr Ser Asn Ser Met Ala Cys Pro 2825 2830 2835 Ile Val Val Ala Val Val Asp Gln Asp Phe Gly Ser Thr Val Phe 2840 2845 2850 Asn Val Pro Thr Lys Val Leu Arg Tyr Gly Tyr His Val Leu His 2855 2860 2865 Phe Ile Thr His Ala Leu Ser Ala Asp Gly Val Gln Cys Tyr Thr 2870 2875 2880 Pro His Ser Gln Ile Ser Tyr Ser Asn Phe Tyr Ala Ser Gly Cys 2885 2890 2895 Val Leu Ser Ser Ala Cys Thr Met Phe Ala Met Ala Asp Gly Ser 2900 2905 2910 Pro Gln Pro Tyr Cys Tyr Thr Asp Gly Leu Met Gln Asn Ala Ser 2915 2920 2925 Leu Tyr Ser Ser Leu Val Pro His Val Arg Tyr Asn Leu Ala Asn 2930 2935 2940 Ala Lys Gly Phe Ile Arg Leu Pro Glu Val Leu Arg Glu Gly Leu 2945 2950 2955 Val Arg Ile Val Arg Thr Arg Ser Met Ser Tyr Cys Arg Val Gly 2960 2965 2970 Leu Cys Glu Glu Ala Asp Glu Gly Ile Cys Phe Asn Phe Asn Gly 2975 2980 2985 Ser Trp Val Leu Asn Asn Asp Tyr Tyr Arg Ser Leu Pro Gly Thr 2990 2995 3000 Phe Cys Gly Arg Asp Val Phe Asp Leu Ile Tyr Gln Leu Phe Lys 3005 3010 3015 Gly Leu Ala Gln Pro Val Asp Phe Leu Ala Leu Thr Ala Ser Ser 3020 3025 3030 Ile Ala Gly Ala Ile Leu Ala Val Ile Val Val Leu Gly Phe Tyr 3035 3040 3045 Tyr Leu Ile Lys Leu Lys Arg Ala Phe Gly Asp Tyr Thr Ser Ile 3050 3055 3060 Val Phe Val Asn Val Ile Val Trp Cys Val Asn Phe Met Met Leu 3065 3070 3075 Phe Val Phe Gln Val Tyr Pro Thr Leu Ser Cys Val Tyr Ala Ile 3080 3085 3090 Cys Tyr Phe Tyr Ala Thr Leu Tyr Phe Pro Ser Glu Ile Ser Val 3095 3100 3105 Ile Met His Leu Gln Trp Leu Val Met Tyr Gly Thr Ile Met Pro 3110 3115 3120 Leu Trp Phe Cys Leu Leu Tyr Ile Ser Val Val Val Ser Asn His 3125 3130 3135 Ala Phe Trp Val Phe Ser Tyr Cys Arg Gln Leu Gly Thr Ser Val 3140 3145 3150 Arg Ser Asp Gly Thr Phe Glu Glu Met Ala Leu Thr Thr Phe Met 3155 3160 3165 Ile Thr Lys Asp Ser Tyr Cys Lys Leu Lys Asn Ser Leu Ser Asp 3170 3175 3180 Val Ala Phe Asn Arg Tyr Leu Ser Leu Tyr Asn Lys Tyr Arg Tyr 3185 3190 3195 Tyr Ser Gly Lys Met Asp Thr Ala Ala Tyr Arg Glu Ala Ala Cys 3200 3205 3210 Ser Gln Leu Ala Lys Ala Met Asp Thr Phe Thr Asn Asn Asn Gly 3215 3220 3225 Ser Asp Val Leu Tyr Gln Pro Pro Thr Ala Ser Val Ser Thr Ser 3230 3235 3240 Phe Leu Gln Ser Gly Ile Val Lys Met Val Asn Pro Thr Ser Lys 3245 3250 3255 Val Glu Pro Cys Ile Val Ser Val Thr Tyr Gly Asn Met Thr Leu 3260 3265 3270 Asn Gly Leu Trp Leu Asp Asp Lys Val Tyr Cys Pro Arg His Val 3275 3280 3285 Ile Cys Ser Ala Ser Asp Met Thr Asn Pro Asp Tyr Thr Asn Leu 3290 3295 3300 Leu Cys Arg Val Thr Ser Ser Asp Phe Thr Val Leu Phe Asp Arg 3305 3310 3315 Leu Ser Leu Thr Val Met Ser Tyr Gln Met Gln Gly Cys Met Leu 3320 3325 3330 Val Leu Thr Val Thr Leu Gln Asn Ser Arg Thr Pro Lys Tyr Thr 3335 3340 3345 Phe Gly Val Val Lys Pro Gly Glu Thr Phe Thr Val Leu Ala Ala 3350 3355 3360 Tyr Asn Gly Lys Pro Gln Gly Ala Phe His Val Thr Met Arg Ser 3365 3370 3375 Ser Tyr Thr Ile Lys Gly Ser Phe Leu Cys Gly Ser Cys Gly Ser 3380 3385 3390 Val Gly Tyr Val Ile Met Gly Asp Cys Val Lys Phe Val Tyr Met 3395 3400 3405 His Gln Leu Glu Leu Ser Thr Gly Cys His Thr Gly Thr Asp Phe 3410 3415 3420 Asn Gly Asp Phe Tyr Gly Pro Tyr Lys Asp Ala Gln Val Val Gln 3425 3430 3435 Leu Pro Val Gln Asp Tyr Ile Gln Ser Val Asn Phe Val Ala Trp 3440 3445 3450 Leu Tyr Ala Ala Ile Leu Asn Asn Cys Asn Trp Phe Val Gln Ser 3455 3460 3465 Asp Lys Cys Ser Val Glu Asp Phe Asn Val Trp Ala Leu Ser Asn 3470 3475 3480 Gly Phe Ser Gln Val Lys Ser Asp Leu Val Ile Asp Ala Leu Ala 3485 3490 3495 Ser Met Thr Gly Val Ser Leu Glu Thr Leu Leu Ala Ala Ile Lys 3500 3505 3510 Arg Leu Lys Asn Gly Phe Gln Gly Arg Gln Ile Met Gly Ser Cys 3515 3520 3525 Ser Phe Glu Asp Glu Leu Thr Pro Ser Asp Val Tyr Gln Gln Leu 3530 3535 3540 Ala Gly Ile Lys Leu Gln Ser Lys Arg Thr Arg Leu Val Lys Gly 3545 3550 3555 Ile Val Cys Trp Ile Met Ala Ser Thr Phe Leu Phe Ser Cys Ile 3560 3565 3570 Ile Thr Ala Phe Val Lys Trp Thr Met Phe Met Tyr Val Thr Thr 3575 3580 3585 Asn Met Leu Ser Ile Thr Phe Cys Ala Leu Cys Val Ile Ser Leu 3590 3595 3600 Ala Met Leu Leu Val Lys His Lys His Leu Tyr Leu Thr Met Tyr 3605 3610 3615 Ile Ile Pro Val Leu Phe Thr Leu Leu Tyr Asn Asn Tyr Leu Val 3620 3625 3630 Val Tyr Lys Gln Thr Phe Arg Gly Tyr Val Tyr Ala Trp Leu Ser 3635 3640 3645 Tyr Tyr Val Pro Ser Val Glu Tyr Thr Tyr Thr Asp Glu Val Ile 3650 3655 3660 Tyr Gly Met Leu Leu Leu Ile Gly Met Val Phe Val Thr Leu Arg 3665 3670 3675 Ser Ile Asn His Asp Leu Phe Ser Phe Ile Met Phe Val Gly Arg 3680 3685 3690 Val Ile Ser Val Val Ser Leu Trp Tyr Met Gly Ser Asn Leu Glu 3695 3700 3705 Glu Glu Ile Leu Leu Met Leu Ala Ser Leu Phe Gly Thr Tyr Thr 3710 3715 3720 Trp Thr Thr Ala Leu Ser Met Ala Ala Ala Lys Val Ile Ala Lys 3725 3730 3735 Trp Val Ala Val Asn Val Leu Tyr Phe Thr Asp Ile Pro Gln Ile 3740 3745 3750 Lys Ile Val Leu Val Cys Tyr Leu Phe Ile Gly Tyr Ile Ile Ser 3755 3760 3765 Cys Tyr Trp Gly Leu Phe Ser Leu Met Asn Ser Leu Phe Arg Met 3770 3775 3780 Pro Leu Gly Val Tyr Asn Tyr Lys Ile Ser Val Gln Glu Leu Arg 3785 3790 3795 Tyr Met Asn Ala Asn Gly Leu Arg Pro Pro Lys Asn Ser Phe Glu 3800 3805 3810 Ala Leu Met Leu Asn Phe Lys Leu Leu Gly Ile Gly Gly Val Pro 3815 3820 3825 Ile Ile Glu Val Ser Gln Phe Gln Ser Lys Leu Thr Asp Val Lys 3830 3835 3840 Cys Ala Asn Gly Gly Leu Leu Asn Cys Leu Gln His Leu His Val 3845 3850 3855 Ala Ser Asn Ser Lys Leu Trp Gln Tyr Cys Ser Thr Leu His Asn 3860 3865 3870 Glu Ile Leu Ala Thr Ser Asp Leu Gly Val Ala Phe Glu Lys Leu 3875 3880 3885 Ala Gln Leu Leu Ile Val Leu Phe Ala Asn Pro Ala Ala Val Asp 3890 3895 3900 Ser Lys Cys Leu Thr Ser Ile Glu Glu Val Cys Asp Asp Tyr Ala 3905 3910 3915 Lys Asp Asn Thr Val Leu Gln Ala Leu Gln Ser Glu Phe Val Asn 3920 3925 3930 Met Ala Ser Phe Val Glu Tyr Glu Val Ala Lys Lys Asn Leu Asp 3935 3940 3945 Glu Ala Cys Ser Ser Gly Ser Ala Asn Gln Gln Gln Leu Lys Gln 3950 3955 3960 Leu Glu Lys Ala Cys Asn Ile Ala Lys Ser Ala Tyr Glu Arg Asp 3965 3970 3975 Arg Ala Val Ala Arg Lys Leu Glu Arg Met Ala Asp Leu Ala Leu 3980 3985 3990 Thr Asn Met Tyr Lys Glu Ala Arg Ile Asn Asp Lys Lys Ser Lys 3995 4000 4005 Val Val Ser Ala Leu Gln Thr Met Leu Phe Ser Met Val Arg Lys 4010 4015 4020 Leu Asp Asn Gln Ala Leu Asn Ser Ile Leu Asp Asn Ala Val Lys 4025 4030 4035 Gly Cys Val Pro Leu Asn Ala Ile Pro Ser Leu Ala Ala Asn Thr 4040 4045 4050 Leu Thr Ile Ile Val Pro Asp Lys Ser Val Tyr Asp Gln Val Val 4055 4060 4065 Asp Asn Val Tyr Val Thr Tyr Ala Gly Asn Val Trp Gln Ile Gln 4070 4075 4080 Thr Ile Gln Asp Ser Asp Gly Thr Asn Lys Gln Leu His Glu Ile 4085 4090 4095 Ser Asp Asp Cys Asn Trp Pro Leu Val Ile Ile Ala Asn Arg His 4100 4105 4110 Asn Glu Val Ser Ala Thr Val Leu Gln Asn Asn Glu Leu Met Pro 4115 4120 4125 Ala Lys Leu Lys Thr Gln Val Val Asn Ser Gly Pro Asp Gln Thr 4130 4135 4140 Cys Asn Thr Pro Thr Gln Cys Tyr Tyr Asn Asn Ser Tyr Asn Gly 4145 4150 4155 Lys Ile Val Tyr Ala Ile Leu Ser Asp Val Asp Gly Leu Lys Tyr 4160 4165 4170 Thr Lys Ile Leu Lys Asp Asp Gly Asn Phe Val Val Leu Glu Leu 4175 4180 4185 Asp Pro Pro Cys Lys Phe Thr Val Gln Asp Val Lys Gly Leu Lys 4190 4195 4200 Ile Lys Tyr Leu Tyr Phe Val Lys Gly Cys Asn Thr Leu Ala Arg 4205 4210 4215 Gly Trp Val Val Gly Thr Ile Ser Ser Thr Val Arg Leu Gln Ala 4220 4225 4230 Gly Thr Ala Thr Glu Tyr Ala Ser Asn Ser Ser Ile Leu Ser Leu 4235 4240 4245 Cys Ala Phe Ser Val Asp Pro Lys Lys Thr Tyr Leu Asp Phe Ile 4250 4255 4260 Gln Gln Gly Gly Thr Pro Ile Ala Asn Cys Val Lys Met Leu Cys 4265 4270 4275 Asp His Ala Gly Thr Gly Met Ala Ile Thr Val Lys Pro Asp Ala 4280 4285 4290 Thr Thr Ser Gln Asp Ser Tyr Gly Gly Ala Ser Val Cys Ile Tyr 4295 4300 4305 Cys Arg Ala Arg Val Glu His Pro Asp Val Asp Gly Leu Cys Lys 4310 4315 4320 Leu Arg Gly Lys Phe Val Gln Val Pro Val Gly Ile Lys Asp Pro 4325 4330 4335 Val Ser Tyr Val Leu Thr His Asp Val Cys Gln Val Cys Gly Phe 4340 4345 4350 Trp Arg Asp Gly Ser Cys Ser Cys Val Ser Thr Asp Thr Thr Val 4355 4360 4365 Gln Ser Lys Asp Thr Phe Phe Lys Arg Val Arg Gly Thr Ser Val 4370 4375 4380 Asp Ala Arg Leu Val Pro Cys Ala Ser Gly Leu Ser Thr Asp Val 4385 4390 4395 Gln Leu Arg Ala Phe Asp Ile Cys Asn Ala Ser Val Ala Gly Ile 4400 4405 4410 Gly Leu His Leu Lys Val Asn Cys Cys Arg Phe Gln Arg Val Asp 4415 4420 4425 Glu Asn Gly Asp Lys Leu Asp Gln Phe Phe Val Val Lys Arg Thr 4430 4435 4440 Asp Leu Thr Ile Tyr Asn Arg Glu Met Glu Cys Tyr Glu Arg Val 4445 4450 4455 Lys Asp Cys Lys Phe Val Ala Glu His Asp Phe Phe Thr Phe Asp 4460 4465 4470 Val Glu Gly Ser Arg Val Pro His Ile Val Arg Lys Asp Leu Thr 4475 4480 4485 Lys Tyr Thr Met Leu Asp Leu Cys Tyr Ala Leu Arg His Phe Asp 4490 4495 4500 Arg Asn Asp Cys Met Leu Leu Cys Asp Ile Leu Ser Ile Tyr Ala 4505 4510 4515 Gly Cys Glu Gln Ser Tyr Phe Thr Lys Lys Asp Trp Tyr Asp Phe 4520 4525 4530 Val Glu Asn Pro Asp Ile Ile Asn Val Tyr Lys Lys Leu Gly Pro 4535 4540 4545 Ile Phe Asn Arg Ala Leu Val Ser Ala Thr Glu Phe Ala Asp Lys 4550 4555 4560 Leu Val Glu Val Gly Leu Val Gly Ile Leu Thr Leu Asp Asn Gln 4565 4570 4575 Asp Leu Asn Gly Lys Trp Tyr Asp Phe Gly Asp Tyr Val Ile Ala 4580 4585 4590 Ala Pro Gly Cys Gly Val Ala Ile Ala Asp Ser Tyr Tyr Ser Tyr 4595 4600 4605 Met Met Pro Met Leu Thr Met Cys His Ala Leu Asp Cys Glu Leu 4610 4615 4620 Tyr Val Asn Asn Ala Tyr Arg Leu Phe Asp Leu Val Gln Tyr Asp 4625 4630 4635 Phe Thr Asp Tyr Lys Leu Glu Leu Phe Asn Lys Tyr Phe Lys His 4640 4645 4650 Trp Ser Met Pro Tyr His Pro Asn Thr Val Asp Cys Gln Asp Asp 4655 4660 4665 Arg Cys Ile Ile His Cys Ala Asn Phe Asn Ile Leu Phe Ser Met 4670 4675 4680 Val Leu Pro Asn Thr Cys Phe Gly Pro Leu Val Arg Gln Ile Phe 4685 4690 4695 Val Asp Gly Val Pro Phe Val Val Ser Ile Gly Tyr His Tyr Lys 4700 4705 4710 Glu Leu Gly Ile Val Met Asn Met Asp Val Asp Thr His Arg Tyr 4715 4720 4725 Arg Leu Ser Leu Lys Asp Leu Leu Leu Tyr Ala Ala Asp Pro Ala 4730 4735 4740 Leu His Val Ala Ser Ala Ser Ala Leu Tyr Asp Leu Arg Thr Cys 4745 4750 4755 Cys Phe Ser Val Ala Ala Ile Thr Ser Gly Val Lys Phe Gln Thr 4760 4765 4770 Val Lys Pro Gly Asn Phe Asn Gln Asp Phe Tyr Asp Phe Ile Leu 4775 4780 4785 Ser Lys Gly Leu Leu Lys Glu Gly Ser Ser Val Asp Leu Lys His 4790 4795 4800 Phe Phe Phe Thr Gln Asp Gly Asn Ala Ala Ile Thr Asp Tyr Asn 4805 4810 4815 Tyr Tyr Lys Tyr Asn Leu Pro Thr Met Val Asp Ile Lys Gln Leu 4820 4825 4830 Leu Phe Val Leu Glu Val Val Tyr Lys Tyr Phe Glu Ile Tyr Asp 4835 4840 4845 Gly Gly Cys Ile Pro Ala Ala Gln Val Ile Val Asn Asn Tyr Asp 4850 4855 4860 Lys Ser Ala Gly Tyr Pro Phe Asn Lys Phe Gly Lys Ala Arg Leu 4865 4870 4875 Tyr Tyr Glu Ala Leu Ser Phe Glu Glu Gln Asp Glu Ile Tyr Ala 4880 4885 4890 Tyr Thr Lys Arg Asn Val Leu Pro Thr Leu Thr Gln Met Asn Leu 4895 4900 4905 Lys Tyr Ala Ile Ser Ala Lys Asn Arg Ala Arg Thr Val Ala Gly 4910 4915 4920 Val Ser Ile Leu Ser Thr Met Thr Gly Arg Met Phe His Gln Lys 4925 4930 4935 Cys Leu Lys Ser Ile Ala Ala Thr Arg Gly Val Pro Val Val Ile 4940 4945 4950 Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asp Asp Met Leu Arg Arg 4955 4960 4965 Leu Ile Lys Asp Val Asp Asn Pro Val Leu Met Gly Trp Asp Tyr 4970 4975 4980 Pro Lys Cys Asp Arg Ala Met Pro Asn Ile Leu Arg Ile Val Ser 4985 4990 4995 Ser Leu Val Leu Ala Arg Lys His Glu Ala Cys Cys Ser Gln Ser 5000 5005 5010 Asp Arg Phe Tyr Arg Leu Ala Asn Glu Cys Ala Gln Val Leu Ser 5015 5020 5025 Glu Ile Val Met Cys Gly Gly Cys Tyr Tyr Val Lys Pro Gly Gly 5030 5035 5040 Thr Ser Ser Gly Asp Ala Thr Thr Ala Phe Ala Asn Ser Val Phe 5045 5050 5055 Asn Ile Cys Gln Ala Val Ser Ala Asn Val Cys Ala Leu Met Ser 5060 5065 5070 Cys Asn Gly Asn Lys Ile Glu Asp Leu Ser Ile Arg Ala Leu Gln 5075 5080 5085 Lys Arg Leu Tyr Ser His Val Tyr Arg Ser Asp Met Val Asp Ser 5090 5095 5100 Thr Phe Val Thr Glu Tyr Tyr Glu Phe Leu Asn Lys His Phe Ser 5105 5110 5115 Met Met Ile Leu Ser Asp Asp Gly Val Val Cys Tyr Asn Ser Asp 5120 5125 5130 Tyr Ala Ser Lys Gly Tyr Ile Ala Asn Ile Ser Ala Phe Gln Gln 5135 5140 5145 Val Leu Tyr Tyr Gln Asn Asn Val Phe Met Ser Glu Ser Lys Cys 5150 5155 5160 Trp Val Glu Asn Asp Ile Asn Asn Gly Pro His Glu Phe Cys Ser 5165 5170 5175 Gln His Thr Met Leu Val Lys Met Asp Gly Asp Asp Val Tyr Leu 5180 5185 5190 Pro Tyr Pro Val Pro Ser Arg Ile Leu Gly Ala Gly Cys Phe Val 5195 5200 5205 Asp Asp Leu Leu Lys Thr Asp Ser Val Leu Leu Ile Glu Arg Phe 5210 5215 5220 Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu Val Tyr His Glu Asn 5225 5230 5235 Glu Glu Tyr Gln Lys Val Phe Arg Val Tyr Leu Glu Tyr Ile Lys 5240 5245 5250 Lys Leu Tyr Asn Glu Leu Gly Asn Gln Ile Leu Asp Ser Tyr Ser 5255 5260 5265 Val Ile Leu Ser Thr Cys Asp Gly Gln Lys Phe Thr Asp Glu Ser 5270 5275 5280 Phe Tyr Lys Asn Met Tyr Leu Arg Ser Ala Val Met Gln Ser Val 5285 5290 5295 Gly Ala Cys Val Val Cys Ser Ser Gln Thr Ser Leu Arg Cys Gly 5300 5305 5310 Ser Cys Ile Arg Lys Pro Leu Leu Cys Cys Lys Cys Cys Tyr Asp 5315 5320 5325 His Val Met Ala Thr Asp His Lys Tyr Val Leu Ser Val Ser Pro 5330 5335 5340 Tyr Val Cys Asn Ala Pro Gly Cys Asp Val Asn Asp Val Thr Lys 5345 5350 5355 Leu Tyr Leu Gly Gly Met Ser Tyr Tyr Cys Glu Asp His Lys Pro 5360 5365 5370 Gln Tyr Ser Phe Lys Leu Val Met Asn Gly Met Val Phe Gly Leu 5375 5380 5385 Tyr Lys Gln Ser Cys Thr Gly Ser Pro Tyr Ile Asp Asp Phe Asn 5390 5395 5400 Arg Ile Ala Ser Cys Lys Trp Thr Asp Val Asp Asp Tyr Ile Leu 5405 5410 5415 Ala Asn Glu Cys Thr Glu Arg Leu Lys Leu Phe Ala Ala Glu Thr 5420 5425 5430 Gln Lys Ala Thr Glu Glu Ala Phe Lys Gln Ser Tyr Ala Ser Ala 5435 5440 5445 Thr Ile Gln Glu Ile Val Ser Glu Arg Glu Leu Ile Leu Ser Trp 5450 5455 5460 Glu Ile Gly Lys Val Lys Pro Pro Leu Asn Lys Asn Tyr Val Phe 5465 5470 5475 Thr Gly Tyr His Phe Thr Lys Asn Gly Lys Thr Val Leu Gly Glu 5480 5485 5490 Tyr Val Phe Asp Lys Ser Glu Leu Thr Asn Gly Val Tyr Tyr Arg 5495 5500 5505 Ala Thr Thr Thr Tyr Lys Leu Ser Val Gly Asp Val Phe Val Leu 5510 5515 5520 Thr Ser His Ser Val Ala Asn Leu Ser Ala Pro Thr Leu Val Pro 5525 5530 5535 Gln Glu Asn Tyr Ser Ser Ile Arg Phe Ala Ser Val Tyr Ser Val 5540 5545 5550 Leu Glu Thr Phe Gln Asn Asn Val Val Asn Tyr Gln His Ile Gly 5555 5560 5565 Met Lys Arg Tyr Cys Thr Val Gln Gly Pro Pro Gly Thr Gly Lys 5570 5575 5580 Ser His Leu Ala Ile Gly Leu Ala Val Tyr Tyr Cys Thr Ala Arg 5585 5590 5595 Val Val Tyr Thr Ala Ala Ser His Ala Ala Val Asp Ala Leu Cys 5600 5605 5610 Glu Lys Ala Tyr Lys Phe Leu Asn Ile Asn Asp Cys Thr Arg Ile 5615 5620 5625 Val Pro Ala Lys Val Arg Val Glu Cys Tyr Asp Lys Phe Lys Ile 5630 5635 5640 Asn Asp Thr Thr Arg Lys Tyr Val Phe Thr Thr Ile Asn Ala Leu 5645 5650 5655 Pro Glu Met Val Thr Asp Ile Val Val Val Asp Glu Val Ser Met 5660 5665 5670 Leu Thr Asn Tyr Glu Leu Ser Val Ile Asn Ala Arg Ile Arg Ala 5675 5680 5685 Lys His Tyr Val Tyr Ile Gly Asp Pro Ala Gln Leu Pro Ala Pro 5690 5695 5700 Arg Val Leu Leu Ser Lys Gly Thr Leu Glu Pro Lys Tyr Phe Asn 5705 5710 5715 Thr Val Thr Lys Leu Met Cys Cys Leu Gly Pro Asp Ile Phe Leu 5720 5725 5730 Gly Thr Cys Tyr Arg Cys Pro Lys Glu Ile Val Asp Thr Val Ser 5735 5740 5745 Ala Leu Val Tyr Glu Asn Lys Leu Lys Ala Lys Asn Glu Ser Ser 5750 5755 5760 Ser Leu Cys Phe Lys Val Tyr Tyr Lys Gly Val Thr Thr His Glu 5765 5770 5775 Ser Ser Ser Ala Val Asn Met Gln Gln Ile Tyr Leu Ile Asn Lys 5780 5785 5790 Phe Leu Lys Ala Asn Pro Leu Trp His Lys Ala Val Phe Ile Ser 5795 5800 5805 Pro Tyr Asn Ser Gln Asn Phe Ala Ala Lys Arg Val Leu Gly Leu 5810 5815 5820 Gln Thr Gln Thr Val Asp Ser Ala Gln Gly Ser Glu Tyr Asp Tyr 5825 5830 5835 Val Ile Tyr Ser Gln Thr Ala Glu Thr Ala His Ser Val Asn Val 5840 5845 5850 Asn Arg Phe Asn Val Ala Ile Thr Arg Ala Lys Lys Gly Ile Leu 5855 5860 5865 Cys Val Met Ser Asn Met Gln Leu Phe Glu Ala Leu Gln Phe Thr 5870 5875 5880 Thr Leu Thr Val Asp Lys Val Pro Gln Ala Val Glu Thr Arg Val 5885 5890 5895 Gln Cys Ser Thr Asn Leu Phe Lys Asp Cys Ser Lys Ser Tyr Ser 5900 5905 5910 Gly Tyr His Pro Ala His Ala Pro Ser Phe Leu Ala Val Asp Asp 5915 5920 5925 Lys Tyr Lys Ala Thr Gly Asp Leu Ala Val Cys Leu Gly Ile Gly 5930 5935 5940 Asp Ser Ala Val Thr Tyr Ser Arg Leu Ile Ser Leu Met Gly Phe 5945 5950 5955 Lys Leu Asp Val Thr Leu Asp Gly Tyr Cys Lys Leu Phe Ile Thr 5960 5965 5970 Lys Glu Glu Ala Val Lys Arg Val Arg Ala Trp Val Gly Phe Asp 5975 5980 5985 Ala Glu Gly Ala His Ala Thr Arg Asp Ser Ile Gly Thr Asn Phe 5990 5995 6000 Pro Leu Gln Leu Gly Phe Ser Thr Gly Ile Asp Phe Val Val Glu 6005 6010 6015 Ala Thr Gly Leu Phe Ala Asp Arg Asp Gly Tyr Ser Phe Lys Lys 6020 6025 6030 Ala Val Ala Lys Ala Pro Pro Gly Glu Gln Phe Lys His Leu Ile 6035 6040 6045 Pro Leu Met Thr Arg Gly Gln Arg Trp Asp Val Val Arg Pro Arg 6050 6055 6060 Ile Val Gln Met Phe Ala Asp His Leu Ile Asp Leu Ser Asp Cys 6065 6070 6075 Val Val Leu Val Thr Trp Ala Ala Asn Phe Glu Leu Thr Cys Leu 6080 6085 6090 Arg Tyr Phe Ala Lys Val Gly Arg Glu Ile Ser Cys Asn Val Ser 6095 6100 6105 Thr Lys Arg Ala Thr Ala Tyr Asn Ser Arg Thr Gly Tyr Tyr Gly 6110 6115 6120 Cys Trp Arg His Ser Val Thr Cys Asp Tyr Leu Tyr Asn Pro Leu 6125 6130 6135 Ile Val Asp Ile Gln Gln Trp Gly Tyr Ile Gly Ser Leu Ser Ser 6140 6145 6150 Asn His Asp Leu Tyr Cys Ser Val His Lys Gly Ala His Val Ala 6155 6160 6165 Ser Ser Asp Ala Ile Met Thr Arg Cys Leu Ala Val Tyr Asp Cys 6170 6175 6180 Phe Cys Asn Asn Ile Asn Trp Asn Val Glu Tyr Pro Ile Ile Ser 6185 6190 6195 Asn Glu Leu Ser Ile Asn Thr Ser Cys Arg Val Leu Gln Arg Val 6200 6205 6210 Met Leu Lys Ala Ala Met Leu Cys Asn Arg Tyr Thr Leu Cys Tyr 6215 6220 6225 Asp Ile Gly Asn Pro Lys Ala Ile Ala Cys Val Lys Asp Phe Asp 6230 6235 6240 Phe Lys Phe Tyr Asp Ala Gln Pro Ile Val Lys Ser Val Lys Thr 6245 6250 6255 Leu Leu Tyr Phe Phe Glu Ala His Lys Asp Ser Phe Lys Asp Gly 6260 6265 6270 Leu Cys Met Phe Trp Asn Cys Asn Val Asp Lys Tyr Pro Pro Asn 6275 6280 6285 Ala Val Val Cys Arg Phe Asp Thr Arg Val Leu Asn Asn Leu Asn 6290 6295 6300 Leu Pro Gly Cys Asn Gly Gly Ser Leu Tyr Val Asn Lys His Ala 6305 6310 6315 Phe His Thr Lys Pro Phe Ser Arg Ala Ala Phe Glu His Leu Lys 6320 6325 6330 Pro Met Pro Phe Phe Tyr Tyr Ser Asp Thr Pro Cys Val Tyr Met 6335 6340 6345 Asp Gly Met Asp Ala Lys Gln Val Asp Tyr Val Pro Leu Lys Ser 6350 6355 6360 Ala Thr Cys Ile Thr Arg Cys Asn Leu Gly Gly Ala Val Cys Leu 6365 6370 6375 Lys His Ala Glu Glu Tyr Arg Glu Tyr Leu Glu Ser Tyr Asn Thr 6380 6385 6390 Ala Thr Thr Ala Gly Phe Thr Phe Trp Val Tyr Lys Thr Phe Asp 6395 6400 6405 Phe Tyr Asn Leu Trp Asn Thr Phe Thr Lys Leu Gln Ser Leu Glu 6410 6415 6420 Asn Val Val Tyr Asn Leu Val Lys Thr Gly His Tyr Thr Gly Gln 6425 6430 6435 Ala Gly Glu Met Pro Cys Ala Ile Ile Asn Asp Lys Val Val Ala 6440 6445 6450 Lys Ile Asp Lys Glu Asp Val Val Ile Phe Ile Asn Asn Thr Thr 6455 6460 6465 Tyr Pro Thr Asn Val Ala Val Glu Leu Phe Ala Lys Arg Ser Ile 6470 6475 6480 Arg His His Pro Glu Leu Lys Leu Phe Arg Asn Leu Asn Ile Asp 6485 6490 6495 Val Cys Trp Lys His Val Ile Trp Asp Tyr Ala Arg Glu Ser Ile 6500 6505 6510 Phe Cys Ser Asn Thr Tyr Gly Val Cys Met Tyr Thr Asp Leu Lys 6515 6520 6525 Leu Ile Asp Lys Leu Asn Val Leu Phe Asp Gly Arg Asp Asn Gly 6530 6535 6540 Ala Leu Glu Ala Phe Lys Arg Ser Asn Asn Gly Val Tyr Ile Ser 6545 6550 6555 Thr Thr Lys Val Lys Ser Leu Ser Met Ile Arg Gly Pro Pro Arg 6560 6565 6570 Ala Glu Leu Asn Gly Val Val Val Asp Lys Val Gly Asp Thr Asp 6575 6580 6585 Cys Val Phe Tyr Phe Ala Val Arg Lys Glu Gly Gln Asp Val Ile 6590 6595 6600 Phe Ser Gln Phe Asp Ser Leu Arg Val Ser Ser Asn Gln Ser Pro 6605 6610 6615 Gln Gly Asn Leu Gly Ser Asn Glu Pro Gly Asn Val Gly Gly Asn 6620 6625 6630 Asp Ala Leu Ala Thr Ser Thr Ile Phe Thr Gln Ser Arg Val Ile 6635 6640 6645 Ser Ser Phe Thr Cys Arg Thr Asp Met Glu Lys Asp Phe Ile Ala 6650 6655 6660 Leu Asp Gln Asp Val Phe Ile Gln Lys Tyr Gly Leu Glu Asp Tyr 6665 6670 6675 Ala Phe Glu His Ile Val Tyr Gly Asn Phe Asn Gln Lys Ile Ile 6680 6685 6690 Gly Gly Leu His Leu Leu Ile Gly Leu Tyr Arg Arg Gln Gln Thr 6695 6700 6705 Ser Asn Leu Val Ile Gln Glu Phe Val Ser Tyr Asp Ser Ser Ile 6710 6715 6720 His Ser Tyr Phe Ile Thr Asp Glu Lys Ser Gly Gly Ser Lys Ser 6725 6730 6735 Val Cys Thr Val Ile Asp Ile Leu Leu Asp Asp Phe Val Ala Leu 6740 6745 6750 Val Lys Ser Leu Asn Leu Asn Cys Val Ser Lys Val Val Asn Val 6755 6760 6765 Asn Val Asp Phe Lys Asp Phe Gln Phe Met Leu Trp Cys Asn Asp 6770 6775 6780 Glu Lys Val Met Thr Phe Tyr Pro Arg Leu Gln Ala Ala Ser Asp 6785 6790 6795 Trp Lys Pro Gly Tyr Ser Met Pro Val Leu Tyr Lys Tyr Leu Asn 6800 6805 6810 Ser Pro Met Glu Arg Val Ser Leu Trp Asn Tyr Gly Lys Pro Val 6815 6820 6825 Thr Leu Pro Thr Gly Cys Met Met Asn Val Ala Lys Tyr Thr Gln 6830 6835 6840 Leu Cys Gln Tyr Leu Asn Thr Thr Thr Leu Ala Val Pro Val Asn 6845 6850 6855 Thr Arg Val Leu His Leu Gly Ala Gly Ser Glu Lys Gly Val Ala 6860 6865 6870 Pro Gly Ser Ala Val Leu Arg Gln Trp Leu Pro Ala Gly Thr Ile 6875 6880 6885 Leu Arg Gln Trp Leu Pro Ala Gly Thr Ile Leu Val His Asn Asp 6890 6895 6900 Leu Tyr Pro Phe Val Ser Asp Ser Val Ala Thr Tyr Phe Gly Asp 6905 6910 6915 Cys Ile Thr Leu Pro Phe Asp Cys Gln Trp Asp Leu Ile Ile Ser 6920 6925 6930 Asp Met Tyr Asp Leu Leu Leu Asp Ile Gly Val His Val Val Arg 6935 6940 6945 Cys Ser Tyr Ile His Cys His Met Ile Arg Asp Lys Leu Ala Leu 6950 6955 6960 Gly Gly Ser Val Ala Ile Lys Ile Thr Glu Phe Ser Trp Asn Ala 6965 6970 6975 Glu Leu Tyr Lys Leu Met Gly Tyr Phe Ala Phe Trp Thr Val Phe 6980 6985 6990 Cys Thr Asn Ala Asn Ala Ser Ser Ser Glu Gly Phe Leu Ile Gly 6995 7000 7005 Ile Asn Tyr Leu Gly Lys Pro Lys Val Glu Ile Asp Gly Asn Val 7010 7015 7020 Met His Ala Ile Ile Cys Phe Gly Glu Ile Pro Gln Phe Gly Thr 7025 7030 7035 Gly Val Leu Ile Ala Cys Leu Ile Trp Leu Asn Ser Arg Leu Ser 7040 7045 7050 Trp Leu Val Met Pro 7055 <210> 23 <211> 6724 <212> PRT <213> EMCR Coronavirus <220> <221> MISC_FEATURE <223> ORF 1AB <220> <221> MISC_FEATURE <222> (4890)..(4890) <223> Unknown amino acid <400> 23 Met Phe Tyr Asn Gln Val Thr Leu Ala Val Ala Ser Asp Ser Glu Ile 1 5 10 15 Ser Gly Phe Gly Phe Ala Ile Pro Ser Val Ala Val Arg Ala Tyr Ser 20 25 30 Glu Ala Ala Ala Gln Gly Phe Gln Ala Cys Arg Phe Val Ala Phe Gly 35 40 45 Leu Gln Asp Cys Val Thr Gly Ile Asn Asp Asp Asp Tyr Val Ile Ala 50 55 60 Leu Thr Gly Thr Asn Gln Leu Cys Ala Lys Ile Leu Leu Phe Ser Asp 65 70 75 80 Arg Pro Leu Asn Leu Arg Gly Trp Leu Ile Phe Ser Asn Ser Asn Tyr 85 90 95 Val Leu Gln Asp Phe Asp Val Val Phe Gly His Gly Ala Gly Ser Val 100 105 110 Val Phe Val Asp Lys Tyr Met Cys Gly Phe Asp Gly Lys Pro Val Leu 115 120 125 Pro Lys Asn Met Trp Glu Phe Arg Asp Tyr Phe Asn Asp Asn Thr Asp 130 135 140 Ser Ile Val Ile Gly Gly Val Thr Tyr Gln Leu Ala Trp Asp Val Ile 145 150 155 160 Arg Lys Asp Leu Ser Tyr Glu Gln Gln Asn Val Leu Ala Ile Glu Ser 165 170 175 Ile His Tyr Leu Gly Thr Thr Gly His Thr Leu Lys Ser Gly Cys Lys 180 185 190 Leu Ile Asn Ala Lys Pro Pro Lys Tyr Ser Ser Lys Val Val Leu Ser 195 200 205 Gly Glu Trp Asn Ala Val Tyr Lys Ala Phe Gly Ser Pro Phe Ile Thr 210 215 220 Asn Gly Ile Ser Leu Leu Asp Ile Ile Val Lys Pro Val Phe Phe Asn 225 230 235 240 Ala Phe Val Lys Cys Asn Cys Gly Ser Glu Asn Trp Ser Val Gly Ala 245 250 255 Trp Asp Gly Tyr Leu Ser Ser Cys Cys Gly Thr Pro Ala Lys Lys Leu 260 265 270 Cys Val Val Pro Gly Asn Val Val Pro Gly Asp Val Ile Ile Thr Ser 275 280 285 Thr Asp Ala Gly Cys Gly Val Lys Tyr Tyr Ala Gly Leu Val Val Lys 290 295 300 His Ile Thr Asn Ile Thr Gly Val Ser Leu Trp Arg Val Thr Ala Val 305 310 315 320 His Ser Asp Gly Met Phe Val Ala Thr Ser Ser Tyr Asp Ala Leu Leu 325 330 335 His Arg Asn Ser Leu Asp Pro Phe Cys Phe Asp Val Asn Thr Leu Leu 340 345 350 Ser Asn Gln Leu Arg Leu Ala Phe Leu Gly Ala Ser Val Thr Glu Asp 355 360 365 Val Lys Phe Ala Ala Ser Thr Gly Val Ile Asp Ile Ser Ala Gly Met 370 375 380 Phe Gly Leu Tyr Asp Asp Ile Leu Thr Asn Asn Lys Pro Trp Phe Val 385 390 395 400 Arg Lys Ala Ser Gly Leu Phe Asp Ala Ile Trp Asp Ala Phe Val Ala 405 410 415 Ala Ile Lys Leu Val Pro Thr Thr Thr Gly Gly Leu Val Arg Phe Val 420 425 430 Lys Ser Ile Ala Ser Thr Val Leu Thr Val Ser Asn Gly Val Ile Ile 435 440 445 Met Cys Ala Asp Val Pro Asp Ala Phe Gln Pro Val Tyr Arg Thr Phe 450 455 460 Thr Gln Ala Ile Cys Ala Ala Phe Asp Phe Ser Leu Asp Val Phe Lys 465 470 475 480 Ile Gly Asp Val Lys Phe Lys Arg Leu Gly Asp Tyr Val Leu Thr Glu 485 490 495 Asn Ala Leu Val Arg Leu Thr Thr Glu Val Val Arg Gly Val Arg Asp 500 505 510 Ala Arg Ile Lys Lys Ala Met Phe Thr Lys Val Val Val Gly Pro Thr 515 520 525 Thr Glu Val Lys Phe Ser Val Ile Glu Leu Ala Thr Val Asn Leu Arg 530 535 540 Leu Val Asp Cys Ala Pro Val Val Cys Pro Lys Gly Lys Ile Val Val 545 550 555 560 Ile Ala Gly Gln Ala Phe Phe Tyr Ser Gly Gly Phe Tyr Arg Phe Met 565 570 575 Val Asp Ser Thr Thr Val Leu Asn Asp Pro Val Phe Thr Gly Glu Leu 580 585 590 Phe Tyr Thr Ile Lys Phe Ser Gly Phe Lys Leu Asp Gly Phe Asn His 595 600 605 Gln Phe Val Asn Ala Ser Ser Ala Thr Asp Ala Ile Ile Ala Val Glu 610 615 620 Leu Leu Leu Ser Asp Phe Lys Thr Ala Val Phe Val Tyr Thr Cys Val 625 630 635 640 Val Asp Gly Cys Ser Val Ile Val Arg Arg Asp Ala Thr Phe Ala Thr 645 650 655 His Val Cys Phe Lys Asp Cys Tyr Ser Ile Trp Glu Gln Phe Cys Ile 660 665 670 Asp Asn Cys Gly Glu Pro Trp Phe Leu Thr Asp Tyr Asn Ala Ile Leu 675 680 685 Gln Ser Asn Asn Pro Gln Cys Ala Ile Val Gln Ala Ser Glu Ser Lys 690 695 700 Val Leu Leu Glu Arg Phe Leu Pro Lys Cys Pro Glu Ile Leu Leu Ser 705 710 715 720 Ile Asp Asp Gly His Leu Trp Asn Leu Phe Val Glu Lys Phe Asn Phe 725 730 735 Val Thr Asp Trp Leu Lys Thr Leu Lys Leu Thr Leu Thr Ser Asn Gly 740 745 750 Leu Leu Gly Asn Cys Ala Lys Arg Phe Arg Arg Val Leu Val Lys Leu 755 760 765 Leu Asp Val Tyr Asn Gly Phe Leu Glu Thr Val Cys Ser Val Val His 770 775 780 Thr Ala Gly Val Cys Ile Lys Tyr Tyr Ala Val Asn Val Pro Tyr Val 785 790 795 800 Val Ile Ser Gly Phe Val Ser Arg Val Ile Arg Arg Glu Arg Cys Asp 805 810 815 Val Thr Phe Pro Cys Val Ser Cys Val Thr Phe Phe Tyr Glu Phe Leu 820 825 830 Asp Thr Cys Phe Gly Val Ser Lys Pro Asn Ala Ile Asp Val Glu His 835 840 845 Leu Glu Leu Lys Glu Thr Val Phe Val Glu Pro Lys Asp Gly Gly Gln 850 855 860 Phe Phe Val Ser Asp Asp Tyr Leu Trp Tyr Val Val Asp Asp Ile Tyr 865 870 875 880 Tyr Pro Ala Ser Cys Asn Gly Val Leu Pro Val Ala Phe Thr Lys Leu 885 890 895 Ala Gly Gly Lys Ile Ser Phe Ser Asp Asp Val Ile Val His Asp Val 900 905 910 Glu Pro Thr His Lys Val Lys Leu Ile Phe Glu Phe Glu Asp Asp Val 915 920 925 Val Thr Ser Leu Cys Lys Lys Ser Phe Gly Lys Ser Ile Ile Tyr Thr 930 935 940 Gly Asp Trp Glu Gly Leu His Glu Val Leu Thr Ser Ala Met Asn Val 945 950 955 960 Ile Gly Gln His Ile Lys Leu Pro Gln Phe Tyr Ile Tyr Asp Glu Glu 965 970 975 Gly Gly Tyr Asp Val Ser Lys Pro Val Met Ile Ser Gln Trp Pro Ile 980 985 990 Ser Asp Asp Ser Asp Gly Cys Val Val Glu Ala Ser Thr Asp Phe His 995 1000 1005 Gln Leu Glu Ser Val Arg Glu Glu Val Asp Ile Ile Glu Gln Pro 1010 1015 1020 Phe Gly Glu Val Glu His Ala Leu Ser Ile Arg Gln Pro Phe Ser 1025 1030 1035 Phe Ser Phe Arg Asp Glu Leu Gly Val Arg Val Leu Asp Gln Ser 1040 1045 1050 Asp Asn Asn Cys Trp Ile Ser Thr Thr Leu Ile Gln Leu Gln Leu 1055 1060 1065 Thr Lys Leu Leu Asp Asp Ser Ile Glu Met Gln Leu Phe Lys Val 1070 1075 1080 Gly Lys Val Asp Ser Ile Val Gln Lys Cys Tyr Glu Leu Ser His 1085 1090 1095 Leu Ile Ser Gly Ser Leu Gly Asp Ser Gly Lys Leu Leu Ser Glu 1100 1105 1110 Leu Leu Lys Asp Lys Tyr Thr Cys Ser Ile Thr Phe Glu Met Ser 1115 1120 1125 Cys Asp Cys Gly Lys Lys Phe Asp Glu Gln Val Gly Cys Leu Phe 1130 1135 1140 Trp Ile Met Pro Tyr Thr Lys Leu Phe Gln Lys Gly Glu Cys Cys 1145 1150 1155 Ile Cys His Lys Met Gln Thr Tyr Lys Leu Val Ser Met Lys Gly 1160 1165 1170 Thr Gly Val Phe Val Gln Asp Pro Ala Pro Ile Asp Ile Asp Ala 1175 1180 1185 Phe Pro Val Arg Pro Ile Cys Ser Ser Val Tyr Leu Gly Val Lys 1190 1195 1200 Gly Ser Gly His Tyr Gln Thr Asn Leu Tyr Ser Phe Asp Lys Ala 1205 1210 1215 Ile Asp Gly Phe Gly Val Phe Asp Ile Lys Asn Ser Ser Val Asn 1220 1225 1230 Thr Val Cys Phe Val Asp Val Asp Phe His Ser Val Glu Ile Glu 1235 1240 1245 Ala Gly Glu Val Lys Pro Phe Ala Val Tyr Lys Asn Val Lys Phe 1250 1255 1260 Tyr Leu Gly Asp Ile Ser His Leu Val Asn Cys Val Ser Phe Asp 1265 1270 1275 Phe Val Val Asn Ala Ala Asn Glu Asn Leu Met His Gly Gly Gly 1280 1285 1290 Val Ala Arg Ala Ile Asp Ile Leu Thr Glu Gly Gln Leu Gln Ser 1295 1300 1305 Leu Ser Lys Asp Tyr Ile Ser Ser Asn Gly Pro Leu Lys Val Gly 1310 1315 1320 Ala Gly Val Met Leu Glu Cys Glu Lys Phe Asn Val Phe Asn Val 1325 1330 1335 Val Gly Pro Arg Thr Gly Lys His Glu His Ser Leu Leu Val Glu 1340 1345 1350 Ala Tyr Asn Ser Ile Leu Phe Glu Asn Gly Ile Pro Leu Met Pro 1355 1360 1365 Leu Leu Ser Cys Gly Ile Phe Gly Val Arg Ile Glu Asn Ser Leu 1370 1375 1380 Lys Ala Leu Phe Ser Cys Asp Ile Asn Lys Pro Leu Gln Val Phe 1385 1390 1395 Val Tyr Ser Ser Asn Glu Glu Gln Ala Val Leu Lys Phe Leu Asp 1400 1405 1410 Gly Leu Asp Leu Thr Pro Val Ile Asp Asp Val Asp Val Val Lys 1415 1420 1425 Pro Phe Arg Val Glu Gly Asn Phe Ser Phe Phe Asp Cys Gly Val 1430 1435 1440 Asn Ala Leu Asp Gly Asp Ile Tyr Leu Leu Phe Thr Asn Ser Ile 1445 1450 1455 Leu Met Leu Asp Lys Gln Gly Gln Leu Leu Asp Thr Lys Leu Asn 1460 1465 1470 Gly Ile Leu Gln Gln Ala Val Leu Asp Tyr Leu Ala Thr Val Lys 1475 1480 1485 Thr Val Pro Ala Gly Asn Leu Val Lys Leu Val Val Glu Ser Cys 1490 1495 1500 Thr Ile Tyr Met Cys Val Val Pro Ser Ile Asn Asp Leu Ser Phe 1505 1510 1515 Asp Lys Asn Leu Gly Arg Cys Val Arg Lys Leu Asn Arg Leu Lys 1520 1525 1530 Thr Cys Val Ile Ala Asn Val Pro Ala Ile Asp Val Leu Lys Lys 1535 1540 1545 Leu Leu Ser Ser Leu Thr Leu Thr Val Lys Phe Val Val Glu Ser 1550 1555 1560 Asn Val Met Asp Val Asn Asp Cys Phe Lys Asn Asp Asn Val Val 1565 1570 1575 Leu Lys Ile Thr Glu Asp Gly Ile Asn Val Lys Asp Val Val Val 1580 1585 1590 Glu Ser Ser Lys Ser Leu Gly Lys Gln Leu Gly Val Val Ser Asp 1595 1600 1605 Gly Val Asp Ser Phe Glu Gly Val Leu Pro Ile Asn Thr Asp Thr 1610 1615 1620 Val Leu Ser Val Ala Pro Glu Val Asp Trp Val Ala Phe Tyr Gly 1625 1630 1635 Phe Glu Lys Ala Ala Leu Phe Ala Ser Leu Asp Val Lys Pro Tyr 1640 1645 1650 Gly Tyr Pro Asn Asp Phe Val Gly Gly Phe Arg Val Leu Gly Thr 1655 1660 1665 Thr Asp Asn Asn Cys Trp Val Asn Ala Thr Cys Ile Ile Leu Gln 1670 1675 1680 Tyr Leu Lys Pro Thr Phe Lys Ser Lys Gly Leu Asn Val Leu Trp 1685 1690 1695 Asn Lys Phe Val Thr Gly Asp Val Gly Pro Phe Val Ser Phe Ile 1700 1705 1710 Tyr Phe Ile Thr Met Ser Ser Lys Gly Gln Lys Gly Asp Ala Glu 1715 1720 1725 Glu Ala Leu Ser Lys Leu Ser Glu Tyr Leu Ile Ser Asp Ser Ile 1730 1735 1740 Val Thr Leu Glu Gln Tyr Ser Thr Cys Asp Ile Cys Lys Ser Thr 1745 1750 1755 Val Val Glu Val Lys Ser Ala Val Val Cys Ala Ser Val Leu Lys 1760 1765 1770 Asp Gly Cys Asp Val Gly Phe Cys Pro His Arg His Lys Leu Arg 1775 1780 1785 Ser Arg Val Lys Phe Val Asn Gly Arg Val Val Ile Thr Asn Val 1790 1795 1800 Gly Glu Pro Ile Ile Ser Gln Pro Ser Lys Leu Leu Asn Gly Ile 1805 1810 1815 Ala Tyr Thr Thr Phe Ser Gly Ser Phe Asp Asn Gly His Tyr Val 1820 1825 1830 Val Tyr Asp Ala Ala Asn Asn Ala Val Tyr Asp Gly Ala Arg Leu 1835 1840 1845 Phe Ala Ser Asp Leu Ser Thr Leu Ala Val Thr Ala Ile Val Val 1850 1855 1860 Val Gly Gly Cys Val Thr Ser Asn Val Pro Pro Ile Val Ser Glu 1865 1870 1875 Lys Ile Ser Val Met Asp Lys Leu Asp Thr Gly Ala Gln Lys Phe 1880 1885 1890 Phe Gln Phe Gly Asp Phe Val Met Asn Asn Ile Val Leu Phe Leu 1895 1900 1905 Thr Trp Leu Leu Ser Met Phe Ser Leu Leu Arg Thr Ser Ile Met 1910 1915 1920 Lys His Asp Ile Lys Val Ile Ala Lys Ala Pro Lys Arg Thr Gly 1925 1930 1935 Val Ile Leu Thr Arg Ser Phe Lys Tyr Asn Ile Arg Ser Ala Leu 1940 1945 1950 Phe Val Val Lys Gln Lys Trp Cys Val Ile Val Thr Leu Phe Lys 1955 1960 1965 Phe Leu Leu Leu Leu Tyr Ala Ile Tyr Ala Leu Val Phe Met Ile 1970 1975 1980 Val Gln Phe Ser Pro Phe Asn Ser Leu Leu Cys Gly Asp Ile Val 1985 1990 1995 Ser Gly Tyr Glu Lys Ser Thr Phe Asn Lys Asp Ile Tyr Cys Gly 2000 2005 2010 Asn Ser Met Val Cys Lys Met Cys Leu Phe Ser Tyr Gln Glu Phe 2015 2020 2025 Asn Asp Leu Asp His Thr Ser Leu Val Trp Lys His Ile Arg Asp 2030 2035 2040 Pro Ile Leu Ile Ser Leu Gln Pro Phe Val Ile Leu Val Ile Leu 2045 2050 2055 Leu Ile Phe Gly Asn Met Tyr Leu Arg Phe Gly Leu Leu Tyr Phe 2060 2065 2070 Val Ala Gln Phe Ile Ser Thr Phe Gly Ser Phe Leu Gly Phe His 2075 2080 2085 Gln Lys Gln Trp Phe Leu His Phe Val Pro Phe Asp Val Leu Cys 2090 2095 2100 Asn Glu Phe Leu Ala Thr Phe Ile Val Cys Lys Ile Val Leu Phe 2105 2110 2115 Val Arg His Ile Ile Val Gly Cys Asn Asn Ala Asp Cys Val Ala 2120 2125 2130 Cys Ser Lys Ser Ala Arg Leu Lys Arg Val Pro Leu Gln Thr Ile 2135 2140 2145 Ile Asn Gly Met His Lys Ser Phe Tyr Val Asn Ala Asn Gly Gly 2150 2155 2160 Thr Cys Phe Cys Asn Lys His Asn Phe Phe Cys Val Asn Cys Asp 2165 2170 2175 Ser Phe Gly Pro Gly Asn Thr Phe Ile Asn Gly Asp Ile Ala Arg 2180 2185 2190 Glu Leu Gly Asn Val Val Lys Thr Ala Val Gln Pro Thr Ala Pro 2195 2200 2205 Ala Tyr Val Ile Ile Asp Lys Val Asp Phe Val Asn Gly Phe Tyr 2210 2215 2220 Arg Leu Tyr Ser Gly Asp Thr Phe Trp Arg Tyr Asp Phe Asp Ile 2225 2230 2235 Thr Glu Ser Lys Tyr Ser Cys Lys Glu Val Leu Lys Asn Cys Asn 2240 2245 2250 Val Leu Glu Asn Phe Ile Val Tyr Asn Asn Ser Gly Ser Asn Ile 2255 2260 2265 Thr Gln Ile Lys Asn Ala Cys Val Tyr Phe Ser Gln Leu Leu Cys 2270 2275 2280 Glu Pro Ile Lys Leu Val Asn Ser Glu Leu Leu Ser Thr Leu Ser 2285 2290 2295 Val Asp Phe Asn Gly Val Leu His Lys Ala Tyr Val Asp Val Leu 2300 2305 2310 Cys Asn Ser Phe Phe Lys Glu Leu Thr Ala Asn Met Ser Met Ala 2315 2320 2325 Glu Cys Lys Ala Thr Leu Gly Leu Thr Val Ser Asp Asp Asp Phe 2330 2335 2340 Val Ser Ala Val Ala Asn Ala His Arg Tyr Asp Val Leu Leu Ser 2345 2350 2355 Asp Leu Ser Phe Asn Asn Phe Phe Ile Ser Tyr Ala Lys Pro Glu 2360 2365 2370 Asp Lys Leu Ser Val Tyr Asp Ile Ala Cys Cys Met Arg Ala Gly 2375 2380 2385 Ser Lys Val Val Asn His Asn Val Leu Ile Lys Glu Ser Ile Pro 2390 2395 2400 Ile Val Trp Gly Val Lys Asp Phe Asn Thr Leu Ser Gln Glu Gly 2405 2410 2415 Lys Lys Tyr Leu Val Lys Thr Thr Lys Ala Lys Gly Leu Thr Phe 2420 2425 2430 Leu Leu Thr Phe Asn Asp Asn Gln Ala Ile Thr Gln Val Pro Ala 2435 2440 2445 Thr Ser Ile Val Ala Lys Gln Gly Ala Gly Phe Lys Arg Thr Tyr 2450 2455 2460 Asn Phe Leu Trp Tyr Val Cys Leu Phe Val Val Ala Leu Phe Ile 2465 2470 2475 Gly Val Ser Phe Ile Asp Tyr Thr Thr Thr Val Thr Ser Phe His 2480 2485 2490 Gly Tyr Asp Phe Lys Tyr Ile Glu Asn Gly Gln Leu Lys Val Phe 2495 2500 2505 Glu Ala Pro Leu His Cys Val Arg Asn Val Phe Asp Asn Phe Asn 2510 2515 2520 Gln Trp His Glu Ala Lys Phe Gly Val Val Thr Thr Asn Ser Asp 2525 2530 2535 Lys Cys Pro Ile Val Val Gly Val Ser Glu Arg Ile Asn Val Val 2540 2545 2550 Pro Gly Val Pro Thr Asn Val Tyr Leu Val Gly Lys Thr Leu Val 2555 2560 2565 Phe Thr Leu Gln Ala Ala Phe Gly Asn Thr Gly Val Cys Tyr Asp 2570 2575 2580 Phe Asp Gly Val Thr Thr Ser Asp Lys Cys Ile Phe Asn Ser Ala 2585 2590 2595 Cys Thr Arg Leu Glu Gly Leu Gly Gly Asp Asn Val Tyr Cys Tyr 2600 2605 2610 Asn Thr Asp Leu Ile Glu Gly Ser Lys Pro Tyr Ser Ile Leu Gln 2615 2620 2625 Pro Asn Ala Tyr Tyr Lys Tyr Asp Val Lys Asn Tyr Val Arg Phe 2630 2635 2640 Pro Glu Ile Leu Ala Arg Gly Phe Gly Leu Arg Thr Ile Arg Thr 2645 2650 2655 Leu Ala Thr Arg Tyr Cys Arg Val Gly Glu Cys Arg Asp Ser His 2660 2665 2670 Lys Gly Val Cys Phe Gly Phe Asp Lys Trp Tyr Val Asn Asp Gly 2675 2680 2685 Arg Val Asp Asp Gly Tyr Ile Cys Gly Asp Gly Leu Ile Asp Leu 2690 2695 2700 Leu Val Asn Val Leu Ser Ile Phe Ser Ser Ser Phe Ser Val Val 2705 2710 2715 Ala Met Ser Gly His Met Leu Phe Asn Phe Leu Phe Ala Ala Phe 2720 2725 2730 Ile Thr Phe Leu Cys Phe Leu Val Thr Lys Phe Lys Arg Val Phe 2735 2740 2745 Gly Asp Leu Ser Tyr Gly Val Phe Thr Val Val Cys Ala Thr Leu 2750 2755 2760 Ile Asn Asn Ile Ser Tyr Val Val Thr Gln Asn Leu Phe Phe Met 2765 2770 2775 Leu Leu Tyr Ala Ile Leu Tyr Phe Val Phe Thr Arg Thr Val Arg 2780 2785 2790 Tyr Ala Trp Ile Trp His Ile Ala Tyr Ile Val Ala Tyr Phe Leu 2795 2800 2805 Leu Ile Pro Trp Trp Leu Leu Thr Trp Phe Ser Phe Ala Ala Phe 2810 2815 2820 Leu Glu Leu Leu Pro Asn Val Phe Lys Leu Lys Ile Ser Thr Gln 2825 2830 2835 Leu Phe Glu Gly Asp Lys Phe Ile Gly Thr Phe Glu Ser Ala Ala 2840 2845 2850 Ala Gly Thr Phe Val Leu Asp Met Arg Ser Tyr Glu Arg Leu Ile 2855 2860 2865 Asn Thr Ile Ser Pro Glu Lys Leu Lys Asn Tyr Ala Ala Ser Tyr 2870 2875 2880 Asn Lys Tyr Lys Tyr Tyr Ser Gly Ser Ala Ser Glu Ala Asp Tyr 2885 2890 2895 Arg Cys Ala Cys Tyr Ala His Leu Ala Lys Ala Met Leu Asp Tyr 2900 2905 2910 Ala Lys Asp His Asn Asp Met Leu Tyr Ser Pro Pro Thr Ile Ser 2915 2920 2925 Tyr Asn Ser Thr Leu Gln Ser Gly Leu Lys Lys Met Ala Gln Pro 2930 2935 2940 Ser Gly Cys Val Glu Arg Cys Val Val Arg Val Cys Tyr Gly Ser 2945 2950 2955 Thr Val Leu Asn Gly Val Trp Leu Gly Asp Thr Val Thr Cys Pro 2960 2965 2970 Arg His Val Ile Ala Pro Ser Thr Thr Val Leu Ile Asp Tyr Asp 2975 2980 2985 His Ala Tyr Ser Thr Met Arg Leu His Asn Phe Ser Val Ser His 2990 2995 3000 Asn Gly Val Phe Leu Gly Val Val Gly Val Thr Met His Gly Ser 3005 3010 3015 Val Leu Arg Ile Lys Val Ser Gln Ser Asn Val His Thr Pro Lys 3020 3025 3030 His Val Phe Lys Thr Leu Lys Pro Gly Ala Ser Phe Asn Ile Leu 3035 3040 3045 Ala Cys Tyr Glu Gly Ile Ala Ser Gly Val Phe Gly Val Asn Leu 3050 3055 3060 Arg Thr Asn Phe Thr Ile Lys Gly Ser Phe Ile Asn Gly Ala Cys 3065 3070 3075 Gly Ser Pro Gly Tyr Asn Val Arg Asn Asp Gly Thr Val Glu Phe 3080 3085 3090 Cys Tyr Leu His Gln Ile Glu Leu Gly Ser Gly Ala His Val Gly 3095 3100 3105 Ser Asp Phe Thr Gly Ser Val Tyr Gly Asn Phe Asp Asp Gln Pro 3110 3115 3120 Ser Leu Gln Val Glu Ser Ala Asn Leu Met Leu Ser Asp Asn Val 3125 3130 3135 Val Ala Phe Leu Tyr Ala Ala Leu Leu Asn Gly Cys Arg Trp Trp 3140 3145 3150 Leu Arg Ser Thr Arg Val Asn Val Asp Gly Phe Asn Glu Trp Ala 3155 3160 3165 Met Ala Asn Gly Tyr Thr Ile Val Ser Ser Val Glu Cys Tyr Ser 3170 3175 3180 Ile Leu Ala Ala Lys Thr Gly Val Ser Val Glu Gln Leu Leu Ala 3185 3190 3195 Ser Ile Gln His Leu His Glu Gly Phe Gly Gly Lys Asn Ile Leu 3200 3205 3210 Gly Tyr Ser Ser Leu Cys Asp Glu Phe Thr Leu Ala Glu Val Val 3215 3220 3225 Lys Gln Met Tyr Gly Val Asn Leu Gln Ser Gly Lys Val Ile Phe 3230 3235 3240 Gly Leu Lys Thr Met Phe Leu Phe Ser Val Phe Phe Thr Met Phe 3245 3250 3255 Trp Ala Glu Leu Phe Ile Tyr Thr Asn Thr Ile Trp Ile Asn Pro 3260 3265 3270 Val Ile Leu Thr Pro Ile Phe Cys Leu Leu Leu Phe Leu Ser Leu 3275 3280 3285 Val Leu Thr Met Phe Leu Lys His Lys Phe Leu Phe Leu Gln Val 3290 3295 3300 Phe Leu Leu Pro Thr Val Ile Ala Thr Ala Leu Tyr Asn Cys Val 3305 3310 3315 Leu Asp Tyr Tyr Ile Val Lys Phe Leu Ala Asp His Phe Asn Tyr 3320 3325 3330 Asn Val Ser Val Leu Gln Met Asp Val Gln Gly Leu Val Asn Val 3335 3340 3345 Leu Val Cys Leu Phe Val Val Phe Leu His Thr Trp Arg Phe Ser 3350 3355 3360 Lys Glu Arg Phe Thr His Trp Phe Thr Tyr Val Cys Ser Leu Ile 3365 3370 3375 Ala Val Ala Tyr Thr Tyr Phe Tyr Ser Gly Asp Phe Leu Ser Leu 3380 3385 3390 Leu Val Met Phe Leu Cys Ala Ile Ser Ser Asp Trp Tyr Ile Gly 3395 3400 3405 Ala Ile Val Phe Arg Leu Ser Arg Leu Ile Ile Phe Phe Ser Pro 3410 3415 3420 Glu Ser Val Phe Ser Val Phe Gly Asp Val Lys Leu Thr Leu Val 3425 3430 3435 Val Tyr Leu Ile Cys Gly Tyr Leu Val Cys Thr Tyr Trp Gly Ile 3440 3445 3450 Leu Tyr Trp Phe Asn Arg Phe Phe Lys Cys Thr Met Gly Val Tyr 3455 3460 3465 Asp Phe Lys Val Ser Ala Ala Glu Phe Lys Tyr Met Val Ala Asn 3470 3475 3480 Gly Leu His Ala Pro Tyr Gly Pro Phe Asp Ala Leu Trp Leu Ser 3485 3490 3495 Phe Lys Leu Leu Gly Ile Gly Gly Asp Arg Cys Ile Lys Ile Ser 3500 3505 3510 Thr Val Gln Ser Lys Leu Thr Asp Leu Lys Cys Thr Asn Val Val 3515 3520 3525 Leu Leu Gly Cys Leu Ser Ser Met Asn Ile Ala Ala Asn Ser Ser 3530 3535 3540 Glu Trp Ala Tyr Cys Val Asp Leu His Asn Lys Ile Asn Leu Cys 3545 3550 3555 Asp Asp Pro Glu Lys Ala Gln Gly Met Leu Leu Ala Leu Leu Ala 3560 3565 3570 Phe Phe Leu Ser Lys His Ser Asp Phe Gly Leu Asp Gly Leu Ile 3575 3580 3585 Asp Ser Tyr Phe Asp Asn Ser Ser Thr Leu Gln Ser Val Ala Ser 3590 3595 3600 Ser Phe Val Ser Met Pro Ser Tyr Ile Ala Tyr Glu Asn Ala Arg 3605 3610 3615 Gln Ala Tyr Glu Asp Ala Ile Ala Asn Gly Ser Ser Ser Gln Leu 3620 3625 3630 Ile Lys Gln Leu Lys Arg Ala Met Asn Ile Ala Lys Ser Glu Phe 3635 3640 3645 Asp His Glu Ile Ser Val Gln Lys Lys Ile Asn Arg Met Ala Glu 3650 3655 3660 Gln Ala Ala Thr Gln Met Tyr Lys Glu Ala Arg Ser Val Asn Arg 3665 3670 3675 Lys Ser Lys Val Ile Ser Ala Met His Ser Leu Leu Phe Gly Met 3680 3685 3690 Leu Arg Arg Leu Asp Met Ser Ser Val Glu Thr Val Leu Asn Leu 3695 3700 3705 Ala Arg Asp Gly Val Val Pro Leu Ser Val Ile Pro Ala Thr Ser 3710 3715 3720 Ala Ser Lys Leu Thr Ile Val Ser Pro Asp Leu Glu Ser Tyr Ser 3725 3730 3735 Lys Ile Val Cys Asp Gly Ser Val His Tyr Ala Gly Val Val Trp 3740 3745 3750 Thr Leu Asn Asp Val Lys Asp Asn Asp Gly Arg Pro Val His Val 3755 3760 3765 Lys Glu Ile Thr Arg Glu Asn Val Glu Thr Leu Thr Trp Pro Leu 3770 3775 3780 Ile Leu Asn Cys Glu Arg Val Val Lys Leu Gln Asn Asn Glu Ile 3785 3790 3795 Met Pro Gly Lys Leu Lys Gln Lys Pro Met Lys Ala Glu Gly Asp 3800 3805 3810 Gly Gly Val Leu Gly Asp Gly Asn Ala Leu Tyr Asn Thr Glu Gly 3815 3820 3825 Gly Lys Thr Phe Met Tyr Ala Tyr Ile Ser Asn Lys Ala Asp Leu 3830 3835 3840 Lys Phe Val Lys Trp Glu Tyr Glu Gly Gly Cys Asn Thr Ile Glu 3845 3850 3855 Leu Asp Ser Pro Cys Arg Phe Met Val Glu Thr Pro Asn Gly Pro 3860 3865 3870 Gln Val Lys Tyr Leu Tyr Phe Val Lys Asn Leu Asn Thr Leu Arg 3875 3880 3885 Arg Gly Ala Val Leu Gly Phe Ile Gly Ala Thr Ile Arg Leu Gln 3890 3895 3900 Ala Gly Lys Gln Thr Glu Leu Ala Val Asn Ser Gly Leu Leu Thr 3905 3910 3915 Ala Cys Ala Phe Ser Val Asp Pro Ala Thr Thr Tyr Leu Glu Ala 3920 3925 3930 Val Lys His Gly Ala Lys Pro Val Ser Asn Cys Ile Lys Met Leu 3935 3940 3945 Ser Asn Gly Ala Gly Asn Gly Gln Ala Ile Thr Thr Ser Val Asp 3950 3955 3960 Ala Asn Thr Asn Gln Asp Ser Tyr Gly Gly Ala Ser Ile Cys Leu 3965 3970 3975 Tyr Cys Arg Ala His Val Pro His Pro Ser Met Asp Gly Tyr Cys 3980 3985 3990 Lys Phe Lys Gly Lys Cys Val Gln Val Pro Ile Gly Cys Leu Asp 3995 4000 4005 Pro Ile Arg Phe Cys Leu Glu Asn Asn Val Cys Asn Val Cys Gly 4010 4015 4020 Cys Trp Leu Gly His Gly Cys Ala Cys Asp Arg Thr Thr Ile Gln 4025 4030 4035 Ser Val Asp Ile Ser Tyr Leu Asn Arg Ala Arg Gly Ser Ser Ala 4040 4045 4050 Ala Arg Leu Glu Pro Cys Asn Gly Thr Asp Ile Asp Lys Cys Val 4055 4060 4065 Arg Ala Phe Asp Ile Tyr Asn Lys Asn Val Ser Phe Leu Gly Lys 4070 4075 4080 Cys Leu Lys Met Asn Cys Val Arg Phe Lys Asn Ala Asp Leu Lys 4085 4090 4095 Asp Gly Tyr Phe Val Ile Lys Arg Cys Thr Lys Ser Val Met Glu 4100 4105 4110 His Glu Gln Ser Met Tyr Asn Leu Leu Asn Phe Ser Gly Ala Leu 4115 4120 4125 Ala Glu His Asp Phe Phe Thr Trp Lys Asp Gly Arg Val Ile Tyr 4130 4135 4140 Gly Asn Val Ser Arg His Asn Leu Thr Lys Tyr Thr Met Met Asp 4145 4150 4155 Leu Val Tyr Ala Met Arg Asn Phe Asp Glu Gln Asn Cys Asp Val 4160 4165 4170 Leu Lys Glu Val Leu Val Leu Thr Gly Cys Cys Asp Asn Ser Tyr 4175 4180 4185 Phe Asp Ser Lys Gly Trp Tyr Asp Pro Val Glu Asn Glu Asp Ile 4190 4195 4200 His Arg Val Tyr Ala Ser Leu Gly Lys Ile Val Ala Arg Ala Met 4205 4210 4215 Leu Lys Cys Val Ala Leu Cys Asp Ala Met Val Ala Lys Gly Val 4220 4225 4230 Val Gly Val Leu Thr Leu Asp Asn Gln Asp Leu Asn Gly Asn Phe 4235 4240 4245 Tyr Asp Phe Gly Asp Phe Val Val Ser Leu Pro Asn Met Gly Val 4250 4255 4260 Pro Cys Cys Thr Ser Tyr Tyr Ser Tyr Met Met Pro Ile Met Gly 4265 4270 4275 Leu Thr Asn Cys Leu Ala Ser Glu Cys Phe Val Lys Ser Asp Ile 4280 4285 4290 Phe Gly Ser Asp Phe Lys Thr Phe Asp Leu Leu Lys Tyr Asp Phe 4295 4300 4305 Thr Glu His Lys Glu Asn Leu Phe Asn Lys Tyr Phe Lys His Trp 4310 4315 4320 Ser Phe Asp Tyr His Pro Asn Cys Ser Asp Cys Tyr Asp Asp Met 4325 4330 4335 Cys Val Ile His Cys Ala Asn Phe Asn Thr Leu Phe Ala Thr Thr 4340 4345 4350 Ile Pro Gly Thr Ala Phe Gly Pro Leu Cys Arg Lys Val Phe Ile 4355 4360 4365 Asp Gly Val Pro Leu Val Thr Thr Ala Gly Tyr His Phe Lys Gln 4370 4375 4380 Leu Gly Leu Val Trp Asn Lys Asp Val Asn Thr His Ser Val Arg 4385 4390 4395 Leu Thr Ile Thr Glu Leu Leu Gln Phe Val Thr Asp Pro Ser Leu 4400 4405 4410 Ile Ile Ala Ser Ser Pro Ala Leu Val Asp Gln Arg Thr Ile Cys 4415 4420 4425 Phe Ser Val Ala Ala Leu Ser Thr Gly Leu Thr Asn Gln Val Val 4430 4435 4440 Lys Pro Gly His Phe Asn Glu Glu Phe Tyr Asn Phe Leu Arg Leu 4445 4450 4455 Arg Gly Phe Phe Asp Glu Gly Ser Glu Leu Thr Leu Lys His Phe 4460 4465 4470 Phe Phe Ala Gln Asn Gly Asp Ala Ala Val Lys Asp Phe Asp Phe 4475 4480 4485 Tyr Arg Tyr Asn Lys Pro Thr Ile Leu Asp Ile Cys Gln Ala Arg 4490 4495 4500 Val Thr Tyr Lys Ile Val Ser Arg Tyr Phe Asp Ile Tyr Glu Gly 4505 4510 4515 Gly Cys Ile Lys Ala Cys Glu Val Val Val Thr Asn Leu Asn Lys 4520 4525 4530 Ser Ala Gly Trp Pro Leu Asn Lys Phe Gly Lys Ala Ser Leu Tyr 4535 4540 4545 Tyr Glu Ser Ile Ser Tyr Glu Glu Gln Asp Ala Leu Phe Ala Leu 4550 4555 4560 Thr Lys Arg Asn Val Leu Pro Thr Met Thr Gln Leu Asn Leu Lys 4565 4570 4575 Tyr Ala Ile Ser Gly Lys Glu Arg Ala Arg Thr Val Gly Gly Val 4580 4585 4590 Ser Leu Leu Ser Thr Met Thr Thr Arg Gln Tyr His Gln Lys His 4595 4600 4605 Leu Lys Ser Ile Val Asn Thr Arg Asn Ala Thr Val Val Ile Gly 4610 4615 4620 Thr Thr Lys Phe Tyr Gly Gly Trp Asn Asn Met Leu Arg Thr Leu 4625 4630 4635 Ile Asp Gly Val Glu Asn Pro Met Leu Met Gly Trp Asp Tyr Pro 4640 4645 4650 Lys Cys Asp Arg Ala Leu Pro Asn Met Ile Arg Met Ile Ser Ala 4655 4660 4665 Met Val Leu Gly Ser Lys His Val Asn Cys Cys Thr Val Thr Asp 4670 4675 4680 Arg Phe Tyr Arg Leu Gly Asn Glu Leu Ala Gln Val Leu Thr Glu 4685 4690 4695 Val Val Tyr Ser Asn Gly Gly Phe Tyr Phe Lys Pro Gly Gly Thr 4700 4705 4710 Thr Ser Gly Asp Ala Ser Thr Ala Tyr Ala Asn Ser Ile Phe Asn 4715 4720 4725 Ile Phe Gln Ala Val Ser Ser Asn Ile Asn Arg Leu Leu Ser Val 4730 4735 4740 Pro Ser Asp Ser Cys Asn Asn Val Asn Val Arg Asp Leu Gln Arg 4745 4750 4755 Arg Leu Tyr Asp Asn Cys Tyr Arg Leu Thr Ser Val Glu Glu Ser 4760 4765 4770 Phe Ile Asp Asp Tyr Tyr Gly Tyr Leu Arg Lys His Phe Ser Met 4775 4780 4785 Met Ile Leu Ser Asp Asp Gly Val Val Cys Tyr Asn Lys Asp Tyr 4790 4795 4800 Ala Glu Leu Gly Tyr Ile Ala Asp Ile Ser Ala Phe Lys Ala Thr 4805 4810 4815 Leu Tyr Tyr Gln Asn Asn Val Phe Met Ser Thr Ser Lys Cys Trp 4820 4825 4830 Val Glu Glu Asp Leu Thr Lys Gly Pro His Glu Phe Cys Ser Gln 4835 4840 4845 His Thr Met Gln Ile Val Asp Lys Asp Gly Thr Tyr Tyr Leu Pro 4850 4855 4860 Tyr Pro Asp Pro Ser Arg Ile Leu Ser Ala Gly Val Phe Val Asp 4865 4870 4875 Asp Val Val Lys Thr Asp Ala Val Val Leu Leu Xaa Arg Tyr Val 4880 4885 4890 Ser Leu Ala Ile Asp Ala Tyr Pro Leu Ser Lys His Pro Asn Ser 4895 4900 4905 Glu Tyr Arg Lys Val Phe Tyr Val Leu Leu Asp Trp Val Lys His 4910 4915 4920 Leu Asn Lys Asn Leu Asn Glu Gly Val Leu Glu Ser Phe Ser Val 4925 4930 4935 Thr Leu Leu Asp Asn Gln Glu Asp Lys Phe Trp Cys Glu Asp Phe 4940 4945 4950 Tyr Ala Ser Met Tyr Glu Asn Ser Thr Ile Leu Gln Ala Ala Gly 4955 4960 4965 Leu Cys Val Val Cys Gly Ser Gln Thr Val Leu Arg Cys Gly Asp 4970 4975 4980 Cys Leu Arg Lys Pro Met Leu Cys Thr Lys Cys Ala Tyr Asp His 4985 4990 4995 Val Phe Gly Thr Asp His Lys Phe Ile Leu Ala Ile Thr Pro Tyr 5000 5005 5010 Val Cys Asn Ala Ser Gly Cys Gly Val Ser Asp Val Lys Lys Leu 5015 5020 5025 Tyr Leu Gly Gly Leu Asn Tyr Tyr Cys Thr Asn His Lys Pro Gln 5030 5035 5040 Leu Ser Phe Pro Leu Cys Ser Ala Gly Asn Ile Phe Gly Leu Tyr 5045 5050 5055 Lys Asn Ser Ala Thr Gly Ser Leu Asp Val Glu Val Phe Asn Arg 5060 5065 5070 Leu Ala Thr Ser Asp Trp Thr Asp Val Arg Asp Tyr Lys Leu Ala 5075 5080 5085 Asn Asp Val Lys Asp Thr Leu Arg Leu Phe Ala Ala Glu Thr Ile 5090 5095 5100 Lys Ala Lys Glu Glu Ser Val Lys Ser Ser Tyr Ala Phe Ala Thr 5105 5110 5115 Leu Lys Glu Val Val Gly Pro Lys Glu Leu Leu Leu Ser Trp Glu 5120 5125 5130 Ser Gly Lys Val Lys Pro Pro Leu Asn Arg Asn Ser Val Phe Thr 5135 5140 5145 Cys Phe Gln Ile Ser Lys Asp Ser Lys Phe Gln Ile Gly Glu Phe 5150 5155 5160 Ile Phe Glu Lys Val Glu Tyr Gly Ser Asp Thr Val Thr Tyr Lys 5165 5170 5175 Ser Thr Val Thr Thr Lys Leu Val Pro Gly Met Ile Phe Val Leu 5180 5185 5190 Thr Ser His Asn Val Gln Pro Leu Arg Ala Pro Thr Ile Ala Asn 5195 5200 5205 Gln Glu Lys Tyr Ser Ser Ile Tyr Lys Leu His Pro Ala Phe Asn 5210 5215 5220 Val Ser Asp Ala Tyr Ala Asn Leu Val Pro Tyr Tyr Gln Leu Ile 5225 5230 5235 Gly Lys Gln Lys Ile Thr Thr Ile Gln Gly Pro Pro Gly Ser Gly 5240 5245 5250 Lys Ser His Cys Ser Ile Gly Leu Gly Leu Tyr Tyr Pro Gly Ala 5255 5260 5265 Arg Ile Val Phe Val Ala Cys Ala His Ala Ala Val Asp Ser Leu 5270 5275 5280 Cys Ala Lys Ala Met Thr Val Tyr Ser Ile Asp Lys Cys Thr Arg 5285 5290 5295 Ile Ile Pro Ala Arg Ala Arg Val Glu Cys Tyr Ser Gly Phe Lys 5300 5305 5310 Pro Asn Asn Thr Ser Ala Gln Tyr Ile Phe Ser Thr Val Asn Ala 5315 5320 5325 Leu Pro Glu Cys Asn Ala Asp Ile Val Val Val Asp Glu Val Ser 5330 5335 5340 Met Cys Thr Asn Tyr Asp Leu Ser Val Ile Asn Gln Arg Leu Ser 5345 5350 5355 Tyr Lys His Ile Val Tyr Val Gly Asp Pro Gln Gln Leu Pro Ala 5360 5365 5370 Pro Arg Val Met Ile Thr Lys Gly Val Met Glu Pro Val Asp Tyr 5375 5380 5385 Asn Val Val Thr Gln Arg Met Cys Ala Ile Gly Pro Asp Val Phe 5390 5395 5400 Leu His Lys Cys Tyr Arg Cys Pro Ala Glu Ile Val Asn Thr Val 5405 5410 5415 Ser Glu Leu Val Tyr Glu Asn Lys Phe Val Pro Val Lys Pro Ala 5420 5425 5430 Ser Lys Gln Cys Phe Lys Ile Phe Phe Lys Gly Asn Val Gln Val 5435 5440 5445 Asp Asn Gly Ser Ser Ile Asn Arg Lys Gln Leu Glu Ile Val Lys 5450 5455 5460 Leu Phe Leu Val Lys Asn Pro Ser Trp Ser Lys Ala Val Phe Ile 5465 5470 5475 Ser Pro Tyr Asn Ser Gln Asn Tyr Val Ala Ser Arg Phe Leu Gly 5480 5485 5490 Leu Gln Ile Gln Thr Val Asp Ser Ser Gln Gly Ser Glu Tyr Asp 5495 5500 5505 Tyr Val Ile Tyr Ala Gln Thr Ser Asp Thr Ala His Ala Cys Asn 5510 5515 5520 Val Asn Arg Phe Asn Val Ala Ile Thr Arg Ala Lys Lys Gly Ile 5525 5530 5535 Phe Cys Val Met Cys Asp Lys Thr Leu Phe Asp Ser Leu Lys Phe 5540 5545 5550 Phe Glu Ile Lys His Ala Asp Leu His Ser Ser Gln Val Cys Gly 5555 5560 5565 Leu Phe Lys Asn Cys Thr Arg Thr Pro Leu Asn Leu Pro Pro Thr 5570 5575 5580 His Ala His Thr Phe Leu Ser Leu Ser Asp Gln Phe Lys Thr Thr 5585 5590 5595 Gly Asp Leu Ala Val Gln Ile Gly Ser Asn Asn Val Cys Thr Tyr 5600 5605 5610 Glu His Val Ile Ser Phe Met Gly Phe Arg Phe Asp Ile Ser Ile 5615 5620 5625 Pro Gly Ser His Ser Leu Phe Cys Thr Arg Asp Phe Ala Ile Arg 5630 5635 5640 Asn Val Arg Gly Trp Leu Gly Met Asp Val Glu Ser Ala His Val 5645 5650 5655 Cys Gly Asp Asn Ile Gly Thr Asn Val Pro Leu Gln Val Gly Phe 5660 5665 5670 Ser Asn Gly Val Asn Phe Val Val Gln Thr Glu Gly Cys Val Ser 5675 5680 5685 Thr Asn Phe Gly Asp Val Ile Lys Pro Val Cys Ala Lys Ser Pro 5690 5695 5700 Pro Gly Glu Gln Phe Arg His Leu Val Pro Phe Leu Arg Lys Gly 5705 5710 5715 Gln Pro Trp Leu Ile Val Arg Arg Arg Ile Val Gln Met Ile Ser 5720 5725 5730 Asp Tyr Leu Ser Asn Leu Ser Asp Ile Leu Val Phe Val Leu Trp 5735 5740 5745 Ala Gly Ser Leu Glu Leu Thr Thr Met Arg Tyr Phe Val Lys Ile 5750 5755 5760 Gly Pro Ile Lys Tyr Cys Tyr Cys Gly Asn Ser Ala Thr Cys Tyr 5765 5770 5775 Asn Ser Val Ser Asn Glu Tyr Cys Cys Phe Lys His Ala Leu Gly 5780 5785 5790 Cys Asp Tyr Val Tyr Asn Pro Tyr Ala Phe Asp Ile Gln Gln Trp 5795 5800 5805 Gly Tyr Val Gly Ser Leu Ser Gln Asn His His Thr Phe Cys Asn 5810 5815 5820 Ile His Arg Asn Glu His Asp Ala Ser Gly Asp Ala Val Met Thr 5825 5830 5835 Arg Cys Leu Ala Val His Asp Cys Phe Val Lys Asn Val Asp Trp 5840 5845 5850 Thr Val Thr Tyr Pro Phe Ile Ala Asn Glu Lys Phe Ile Asn Gly 5855 5860 5865 Cys Gly Arg Asn Val Gln Gly His Val Val Arg Ala Ala Leu Lys 5870 5875 5880 Leu Tyr Lys Pro Ser Val Ile His Asp Ile Gly Asn Pro Lys Gly 5885 5890 5895 Val Arg Cys Ala Val Thr Asp Ala Lys Trp Tyr Cys Tyr Asp Lys 5900 5905 5910 Gln Pro Val Asn Ser Asn Val Lys Leu Leu Asp Tyr Asp Tyr Ala 5915 5920 5925 Thr His Gly Gln Leu Asp Gly Leu Cys Leu Phe Trp Asn Cys Asn 5930 5935 5940 Val Asp Met Tyr Pro Glu Phe Ser Ile Val Cys Arg Phe Asp Thr 5945 5950 5955 Arg Thr Arg Ser Val Phe Asn Leu Glu Gly Val Asn Gly Gly Ser 5960 5965 5970 Leu Tyr Val Asn Lys His Ala Phe His Thr Pro Ala Tyr Asp Lys 5975 5980 5985 Arg Ala Phe Val Lys Leu Lys Pro Met Pro Phe Phe Tyr Phe Asp 5990 5995 6000 Asp Ser Asp Cys Asp Val Val Gln Glu Gln Val Asn Tyr Val Pro 6005 6010 6015 Leu Arg Ala Ser Ser Cys Val Thr Arg Cys Asn Ile Gly Gly Ala 6020 6025 6030 Val Cys Ser Lys His Ala Asn Leu Tyr Gln Lys Tyr Val Glu Ala 6035 6040 6045 Tyr Asn Thr Phe Thr Gln Ala Gly Phe Asn Ile Trp Val Pro His 6050 6055 6060 Ser Phe Asp Val Tyr Asn Leu Trp Gln Ile Phe Ile Glu Thr Asn 6065 6070 6075 Leu Gln Ser Leu Glu Asn Ile Ala Phe Asn Val Val Lys Lys Gly 6080 6085 6090 Cys Phe Thr Gly Val Asp Gly Glu Leu Pro Val Ala Val Val Asn 6095 6100 6105 Asp Lys Val Phe Val Arg Tyr Gly Asp Val Asp Asn Leu Val Phe 6110 6115 6120 Thr Asn Lys Thr Thr Leu Pro Thr Asn Val Ala Phe Glu Leu Phe 6125 6130 6135 Ala Lys Arg Lys Met Gly Leu Thr Pro Pro Leu Ser Ile Leu Lys 6140 6145 6150 Asn Leu Gly Val Val Ala Thr Tyr Lys Phe Val Leu Trp Asp Tyr 6155 6160 6165 Glu Ala Glu Arg Pro Phe Thr Ser Tyr Thr Lys Ser Val Cys Lys 6170 6175 6180 Tyr Thr Asp Phe Asn Glu Asp Val Cys Val Cys Phe Asp Asn Ser 6185 6190 6195 Ile Gln Gly Ser Tyr Glu Arg Phe Thr Leu Thr Thr Asn Ala Val 6200 6205 6210 Leu Phe Ser Thr Val Val Ile Lys Asn Leu Thr Pro Ile Lys Leu 6215 6220 6225 Asn Phe Gly Met Leu Asn Gly Met Pro Val Ser Ser Ile Lys Ser 6230 6235 6240 Asp Lys Gly Val Glu Lys Leu Val Asn Trp Tyr Thr Tyr Val Arg 6245 6250 6255 Lys Asn Gly Gln Phe Gln Asp His Tyr Asp Gly Phe Tyr Thr Gln 6260 6265 6270 Gly Arg Asn Leu Ser Asp Phe Thr Pro Arg Ser Asp Met Glu Tyr 6275 6280 6285 Asp Phe Leu Asn Met Asp Met Gly Val Phe Ile Asn Lys Tyr Gly 6290 6295 6300 Leu Glu Asp Phe Asn Phe Glu His Val Val Tyr Gly Asp Val Ser 6305 6310 6315 Lys Thr Thr Leu Gly Gly Leu His Leu Leu Ile Ser Gln Phe Arg 6320 6325 6330 Leu Ser Lys Met Gly Val Leu Lys Ala Asp Asp Phe Val Thr Ala 6335 6340 6345 Ser Asp Thr Thr Leu Arg Cys Cys Thr Val Thr Tyr Leu Asn Glu 6350 6355 6360 Leu Ser Ser Lys Val Val Cys Thr Tyr Met Asp Leu Leu Leu Asp 6365 6370 6375 Asp Phe Val Thr Ile Leu Lys Ser Leu Asp Leu Gly Val Ile Ser 6380 6385 6390 Lys Val His Glu Val Ile Ile Asp Asn Lys Pro Tyr Arg Trp Met 6395 6400 6405 Leu Trp Cys Lys Asp Asn His Leu Ser Thr Phe Tyr Pro Gln Leu 6410 6415 6420 Gln Ser Ala Glu Trp Lys Cys Gly Tyr Ala Met Pro Gln Ile Tyr 6425 6430 6435 Lys Leu Gln Arg Met Cys Leu Glu Pro Cys Asn Leu Tyr Asn Tyr 6440 6445 6450 Gly Ala Gly Ile Lys Leu Pro Ser Gly Ile Met Leu Asn Val Val 6455 6460 6465 Lys Tyr Thr Gln Leu Cys Gln Tyr Leu Asn Ser Thr Thr Met Cys 6470 6475 6480 Val Pro His Asn Met Arg Val Leu His Tyr Gly Ala Gly Ser Asp 6485 6490 6495 Lys Gly Val Ala Pro Gly Thr Thr Val Leu Lys Arg Trp Leu Pro 6500 6505 6510 Pro Asp Ala Ile Ile Ile Asp Asn Asp Ile Asn Asp Tyr Val Ser 6515 6520 6525 Asp Ala Asp Phe Ser Ile Thr Gly Asp Cys Ala Thr Val Tyr Leu 6530 6535 6540 Glu Asp Lys Phe Asp Leu Leu Ile Ser Asp Met Tyr Asp Gly Arg 6545 6550 6555 Ile Lys Phe Cys Asp Gly Glu Asn Val Ser Lys Asp Gly Phe Phe 6560 6565 6570 Thr Tyr Leu Asn Gly Val Ile Arg Glu Lys Leu Ala Ile Gly Gly 6575 6580 6585 Ser Val Ala Ile Lys Ile Thr Glu Tyr Ser Trp Asn Lys Tyr Leu 6590 6595 6600 Tyr Glu Leu Ile Gln Arg Phe Ala Phe Trp Thr Leu Phe Cys Thr 6605 6610 6615 Ser Val Asn Thr Ser Ser Ser Glu Ala Phe Leu Ile Gly Ile Asn 6620 6625 6630 Tyr Leu Gly Asp Phe Ile Gln Gly Pro Phe Ile Ala Gly Asn Thr 6635 6640 6645 Val His Ala Asn Tyr Ile Phe Trp Arg Asn Ser Thr Ile Met Ser 6650 6655 6660 Leu Ser Tyr Asn Ser Val Leu Asp Leu Ser Lys Phe Glu Cys Lys 6665 6670 6675 His Lys Ala Thr Val Val Val Thr Leu Lys Asp Ser Asp Val Asn 6680 6685 6690 Asp Met Val Leu Ser Leu Ile Lys Ser Gly Arg Leu Leu Leu Arg 6695 6700 6705 Asn Ser Gly Arg Phe Gly Gly Phe Ser Asn His Leu Val Ser Thr 6710 6715 6720 Lys <210> 24 <211> 7123 <212> PRT <213> murine hepatitis virus <220> <221> MISC_FEATURE <223> ORF 1AB <400> 24 Met Ala Lys Met Gly Lys Tyr Gly Leu Gly Phe Lys Trp Ala Pro Glu 1 5 10 15 Phe Pro Trp Met Leu Pro Asn Ala Ser Glu Lys Leu Gly Ser Pro Glu 20 25 30 Arg Ser Glu Glu Asp Gly Phe Cys Pro Ser Ala Ala Gln Glu Pro Lys 35 40 45 Thr Lys Gly Lys Thr Leu Ile Asn His Val Arg Val Asp Cys Ser Arg 50 55 60 Leu Pro Ala Leu Glu Cys Cys Val Gln Ser Ala Ile Ile Arg Asp Ile 65 70 75 80 Phe Val Asp Glu Asp Pro Leu Asn Val Glu Ala Ser Thr Met Met Ala 85 90 95 Leu Gln Phe Gly Ser Ala Val Leu Val Lys Pro Ser Lys Arg Leu Ser 100 105 110 Ile Gln Ala Trp Ala Lys Leu Gly Val Leu Pro Lys Thr Pro Ala Met 115 120 125 Gly Leu Phe Lys Arg Phe Cys Leu Cys Asn Thr Arg Glu Cys Val Cys 130 135 140 Asp Ala His Val Ala Phe Gln Leu Phe Thr Val Gln Pro Asp Gly Val 145 150 155 160 Cys Leu Gly Asn Gly Arg Phe Ile Gly Trp Phe Val Pro Val Thr Ala 165 170 175 Ile Pro Ala Tyr Ala Lys Gln Trp Leu Gln Pro Trp Ser Ile Leu Leu 180 185 190 Arg Lys Gly Gly Asn Lys Gly Ser Val Thr Ser Gly His Phe Arg Arg 195 200 205 Ala Val Thr Met Pro Val Tyr Asp Phe Asn Val Glu Asp Ala Cys Glu 210 215 220 Glu Val His Leu Asn Pro Lys Gly Lys Tyr Ser Arg Lys Ala Tyr Ala 225 230 235 240 Leu Leu Lys Gly Tyr Arg Gly Val Lys Ser Ile Leu Phe Leu Asp Gln 245 250 255 Tyr Gly Cys Asp Tyr Thr Gly Arg Leu Ala Lys Gly Leu Glu Asp Tyr 260 265 270 Gly Asp Cys Thr Leu Glu Glu Met Lys Glu Leu Phe Pro Val Trp Cys 275 280 285 Asp Ser Leu Asp Asn Glu Val Val Val Ala Trp His Val Asp Arg Asp 290 295 300 Pro Arg Ala Val Met Arg Leu Gln Thr Leu Ala Thr Ile Arg Ser Ile 305 310 315 320 Gly Tyr Val Gly Gln Pro Thr Glu Asp Leu Val Asp Gly Asp Val Val 325 330 335 Val Arg Glu Pro Ala His Leu Leu Ala Ala Asn Ala Ile Val Lys Arg 340 345 350 Leu Pro Arg Leu Val Glu Thr Met Leu Tyr Thr Asp Ser Ser Val Thr 355 360 365 Glu Phe Cys Tyr Lys Thr Lys Leu Cys Asp Cys Gly Phe Ile Thr Gln 370 375 380 Phe Gly Tyr Val Asp Cys Cys Gly Asp Ala Cys Asp Phe Arg Gly Trp 385 390 395 400 Val Pro Gly Asn Met Met Asp Gly Phe Leu Cys Pro Gly Cys Ser Lys 405 410 415 Ser Tyr Met Pro Trp Glu Leu Glu Ala Gln Ser Ser Gly Val Ile Pro 420 425 430 Lys Gly Gly Val Leu Phe Thr Gln Ser Thr Asp Thr Val Asn Arg Glu 435 440 445 Ser Phe Lys Leu Tyr Gly His Ala Val Val Pro Phe Gly Ser Ala Val 450 455 460 Tyr Trp Ser Pro Tyr Pro Gly Met Trp Leu Pro Val Ile Trp Ser Ser 465 470 475 480 Val Lys Ser Tyr Ala Asp Leu Thr Tyr Thr Gly Val Val Gly Cys Lys 485 490 495 Ala Ile Val Gln Glu Thr Asp Ala Ile Cys Arg Ser Leu Tyr Met Asp 500 505 510 Tyr Val Gln His Lys Cys Gly Asn Leu Glu Gln Arg Ala Ile Leu Gly 515 520 525 Leu Asp Asp Val Tyr His Arg Gln Leu Leu Val Asn Arg Gly Asp Tyr 530 535 540 Ser Leu Leu Leu Glu Asn Val Asp Leu Phe Val Lys Arg Arg Ala Glu 545 550 555 560 Phe Ala Cys Lys Phe Ala Thr Cys Gly Asp Gly Leu Val Pro Leu Leu 565 570 575 Leu Asp Gly Leu Val Pro Arg Ser Tyr Tyr Leu Ile Lys Ser Gly Gln 580 585 590 Ala Phe Thr Ser Met Met Val Asn Phe Ser His Glu Val Thr Asp Met 595 600 605 Cys Met Asp Met Ala Leu Leu Phe Met His Asp Val Lys Val Ala Thr 610 615 620 Lys Tyr Val Lys Lys Val Thr Gly Lys Leu Ala Val Arg Phe Lys Ala 625 630 635 640 Leu Gly Val Ala Val Val Arg Lys Ile Thr Glu Trp Phe Asp Leu Ala 645 650 655 Val Asp Thr Ala Ala Ser Ala Ala Gly Trp Leu Cys Tyr Gln Leu Val 660 665 670 Asn Gly Leu Phe Ala Val Ala Asn Gly Gly Ile Thr Phe Leu Ser Asp 675 680 685 Val Pro Glu Leu Val Lys Asn Phe Val Asp Lys Phe Lys Val Phe Phe 690 695 700 Lys Val Leu Ile Asp Ser Met Ser Val Ser Val Leu Ser Gly Leu Thr 705 710 715 720 Val Val Lys Thr Ala Ser Asn Arg Val Cys Leu Ala Gly Cys Lys Val 725 730 735 Tyr Glu Val Val Gln Lys Arg Leu Ser Ala Tyr Val Met Pro Val Gly 740 745 750 Cys Asn Glu Ala Thr Cys Leu Val Gly Glu Ile Glu Pro Ala Val Val 755 760 765 Glu Asp Asp Val Val Asp Val Val Lys Ala Pro Leu Thr Tyr Gln Gly 770 775 780 Cys Cys Lys Pro Pro Thr Ser Phe Glu Lys Ile Cys Val Val Asp Lys 785 790 795 800 Leu Tyr Met Ala Lys Cys Gly Asp Gln Phe Tyr Pro Val Val Val Asp 805 810 815 Asn Asp Thr Ile Gly Val Leu Asp Gln Cys Trp Arg Phe Pro Cys Ala 820 825 830 Gly Lys Lys Val Glu Phe Asn Asp Lys Pro Lys Val Lys Glu Ile Pro 835 840 845 Ser Thr Arg Lys Ile Lys Ile Asn Phe Ala Leu Asp Ala Thr Phe Asp 850 855 860 Ser Val Leu Ser Lys Ala Cys Ser Glu Phe Glu Val Asp Lys Asp Val 865 870 875 880 Thr Leu Asp Glu Leu Leu Asp Val Val Leu Asp Ala Val Glu Ser Thr 885 890 895 Leu Ser Pro Cys Lys Glu His Asp Val Ile Gly Thr Lys Val Cys Ala 900 905 910 Leu Leu Asn Arg Leu Ala Glu Asp Tyr Val Tyr Leu Phe Asp Glu Gly 915 920 925 Gly Glu Glu Val Ile Ala Pro Lys Met Tyr Cys Ser Phe Ser Ala Pro 930 935 940 Asp Asp Glu Asp Cys Val Ala Ala Asp Val Val Asp Ala Asp Glu Asn 945 950 955 960 Gln Gly Asp Asp Ala Asp Asp Ser Ala Ala Leu Val Thr Asp Thr Gln 965 970 975 Glu Glu Asp Gly Val Ala Lys Gly Gln Val Gly Val Ala Glu Ser Asp 980 985 990 Ala Arg Leu Asp Gln Val Glu Ala Phe Asp Ile Glu Lys Val Glu Asp 995 1000 1005 Pro Ile Leu Asn Glu Leu Ser Ala Glu Leu Asn Ala Pro Ala Asp 1010 1015 1020 Lys Thr Tyr Glu Asp Val Leu Ala Phe Asp Ala Ile Tyr Ser Glu 1025 1030 1035 Ala Leu Ser Ala Phe Tyr Ala Val Pro Gly Asp Glu Thr His Phe 1040 1045 1050 Lys Val Cys Gly Phe Tyr Ser Pro Ala Ile Glu Arg Thr Asn Cys 1055 1060 1065 Trp Leu Arg Ser Thr Leu Ile Val Met Gln Ser Leu Pro Leu Glu 1070 1075 1080 Phe Lys Asp Leu Glu Met Gln Lys Leu Trp Leu Ser Tyr Lys Ser 1085 1090 1095 Ser Tyr Asn Lys Glu Phe Val Asp Lys Leu Val Lys Ser Val Pro 1100 1105 1110 Lys Ser Ile Ile Leu Pro Gln Gly Gly Tyr Val Ala Asp Phe Ala 1115 1120 1125 Tyr Phe Phe Leu Ser Gln Cys Ser Phe Lys Ala Tyr Ala Asn Trp 1130 1135 1140 Arg Cys Leu Lys Cys Asp Met Asp Leu Lys Leu Gln Gly Leu Asp 1145 1150 1155 Ala Met Phe Phe Tyr Gly Asp Val Val Ser His Val Cys Lys Cys 1160 1165 1170 Gly Thr Gly Met Thr Leu Leu Ser Ala Asp Ile Pro Tyr Thr Leu 1175 1180 1185 His Phe Gly Leu Arg Asp Asp Lys Phe Cys Ala Phe Tyr Thr Pro 1190 1195 1200 Arg Lys Val Phe Arg Ala Ala Cys Val Val Asp Val Asn Asp Cys 1205 1210 1215 His Ser Met Ala Val Val Asp Gly Lys Gln Ile Asp Gly Lys Val 1220 1225 1230 Val Thr Lys Phe Asn Gly Asp Lys Tyr Asp Phe Met Val Gly His 1235 1240 1245 Gly Met Ala Phe Ser Met Ser Ala Phe Glu Ile Ala Gln Leu Tyr 1250 1255 1260 Gly Ser Cys Ile Thr Pro Asn Val Cys Phe Val Lys Gly Asp Val 1265 1270 1275 Ile Lys Val Leu Arg Arg Val Gly Ala Glu Val Ile Val Asn Pro 1280 1285 1290 Ala Asn Gly Arg Met Ala His Gly Ala Gly Val Ala Gly Ala Ile 1295 1300 1305 Ala Lys Ala Ala Gly Lys Ser Phe Ile Lys Glu Thr Ala Asp Met 1310 1315 1320 Val Lys Asn Gln Gly Val Cys Gln Val Gly Glu Cys Tyr Glu Ser 1325 1330 1335 Thr Gly Gly Asn Leu Cys Lys Thr Val Leu Asn Ile Val Gly Pro 1340 1345 1350 Asp Ala Arg Gly His Gly Lys Gln Cys Tyr Ser Phe Leu Glu Arg 1355 1360 1365 Ala Tyr Gln His Ile Asn Lys Cys Asp Asp Val Val Thr Thr Leu 1370 1375 1380 Ile Ser Ala Gly Ile Phe Ser Val Pro Thr Asp Val Ser Leu Thr 1385 1390 1395 Tyr Leu Ile Gly Val Val Thr Lys Asn Val Ile Leu Val Ser Asn 1400 1405 1410 Asn Lys Asp Asp Phe Asp Val Ile Glu Lys Cys Gln Val Thr Ser 1415 1420 1425 Ile Ala Gly Thr Lys Ala Leu Ser Leu Gln Leu Ala Lys Asn Leu 1430 1435 1440 Cys Arg Asp Val Lys Phe Glu Thr Asn Ala Cys Asp Ser Leu Phe 1445 1450 1455 Ser Asp Ser Cys Phe Val Ser Ser Tyr Asp Val Leu Gln Glu Val 1460 1465 1470 Glu Leu Leu Arg His Asp Ile Gln Leu Asp Asp Asp Ala Arg Val 1475 1480 1485 Phe Val Gln Ala His Met Asp Asn Leu Pro Ala Asp Trp Arg Leu 1490 1495 1500 Val Asn Lys Phe Asp Ser Val Asp Gly Val Arg Thr Val Lys Tyr 1505 1510 1515 Phe Glu Cys Pro Gly Glu Ile Phe Val Ser Ser Gln Gly Lys Lys 1520 1525 1530 Phe Gly Tyr Val Gln Asn Gly Ser Phe Lys Val Ala Ser Val Ser 1535 1540 1545 Gln Ile Arg Ala Leu Leu Ala Asn Lys Val Asp Val Leu Cys Thr 1550 1555 1560 Val Asp Gly Val Asn Phe Arg Ser Cys Cys Val Ala Glu Gly Glu 1565 1570 1575 Val Phe Gly Lys Thr Leu Gly Ser Val Phe Cys Asp Gly Ile Asn 1580 1585 1590 Val Thr Lys Val Arg Cys Ser Ala Ile His Lys Gly Lys Val Phe 1595 1600 1605 Phe Gln Tyr Ser Gly Leu Ser Ala Ala Asp Leu Val Ala Val Thr 1610 1615 1620 Asp Ala Phe Gly Phe Asp Glu Pro Gln Leu Leu Lys Tyr Tyr Asn 1625 1630 1635 Met Leu Gly Met Cys Lys Trp Pro Val Val Val Cys Gly Asn Tyr 1640 1645 1650 Phe Ala Phe Lys Gln Ser Asn Asn Asn Cys Tyr Ile Asn Val Ala 1655 1660 1665 Cys Leu Met Leu Gln His Leu Ser Leu Lys Phe His Lys Trp Gln 1670 1675 1680 Trp Gln Glu Ala Trp Asn Glu Phe Arg Ser Gly Lys Pro Leu Arg 1685 1690 1695 Phe Val Ser Leu Val Leu Ala Lys Gly Ser Phe Lys Phe Asn Glu 1700 1705 1710 Pro Ser Asp Ser Thr Asp Phe Met Arg Val Val Leu Arg Glu Ala 1715 1720 1725 Asp Leu Ser Gly Ala Thr Cys Asp Phe Glu Phe Val Cys Lys Cys 1730 1735 1740 Gly Val Lys Gln Glu Gln Arg Lys Gly Val Asp Ala Val Met His 1745 1750 1755 Phe Gly Thr Leu Asp Lys Gly Asp Leu Ala Lys Gly Tyr Thr Ile 1760 1765 1770 Ala Cys Thr Cys Gly Asn Lys Leu Val His Cys Thr Gln Leu Asn 1775 1780 1785 Val Pro Phe Leu Ile Cys Ser Asn Lys Pro Glu Gly Lys Lys Leu 1790 1795 1800 Pro Asp Asp Val Val Ala Ala Asn Ile Phe Thr Gly Gly Ser Leu 1805 1810 1815 Gly His Tyr Thr His Val Lys Cys Lys Pro Lys Tyr Gln Leu Tyr 1820 1825 1830 Asp Ala Cys Asn Val Ser Lys Val Ser Glu Ala Lys Gly Asn Phe 1835 1840 1845 Thr Asp Cys Leu Tyr Leu Lys Asn Leu Lys Gln Thr Phe Ser Ser 1850 1855 1860 Lys Leu Thr Thr Phe Tyr Leu Asp Asp Val Lys Cys Val Glu Tyr 1865 1870 1875 Asn Pro Asp Leu Ser Gln Tyr Tyr Cys Glu Ser Gly Lys Tyr Tyr 1880 1885 1890 Thr Lys Pro Ile Ile Lys Ala Gln Phe Arg Thr Phe Glu Lys Val 1895 1900 1905 Glu Gly Val Tyr Thr Asn Phe Lys Leu Val Gly His Ser Ile Ala 1910 1915 1920 Glu Lys Phe Asn Ala Lys Leu Gly Phe Asp Cys Asn Ser Pro Phe 1925 1930 1935 Thr Glu Tyr Lys Ile Thr Glu Trp Pro Thr Ala Thr Gly Asp Val 1940 1945 1950 Val Leu Ala Ser Asp Asp Leu Tyr Val Ser Arg Tyr Ser Gly Gly 1955 1960 1965 Cys Val Thr Phe Gly Lys Pro Val Ile Trp Leu Gly His Glu Glu 1970 1975 1980 Ala Ser Leu Lys Ser Leu Thr Tyr Phe Asn Arg Pro Ser Val Val 1985 1990 1995 Cys Glu Asn Lys Phe Asn Val Leu Pro Val Asp Val Ser Glu Pro 2000 2005 2010 Thr Asp Lys Gly Pro Val Pro Ala Ala Val Leu Val Thr Gly Ala 2015 2020 2025 Leu Ser Gly Ala Ala Thr Ala Pro Gly Thr Ala Lys Glu Gln Lys 2030 2035 2040 Val Cys Ala Ser Asp Ser Val Val Asp Gln Val Val Ser Gly Phe 2045 2050 2055 Leu Ser Asp Leu Ser Gly Ala Thr Val Asp Val Lys Glu Val Lys 2060 2065 2070 Leu Asn Gly Val Lys Lys Pro Ile Lys Val Glu Asp Ser Val Val 2075 2080 2085 Val Asn Asp Pro Thr Ser Glu Thr Lys Val Val Lys Ser Leu Ser 2090 2095 2100 Ile Val Asp Val Tyr Asp Met Phe Leu Thr Gly Cys Arg Tyr Val 2105 2110 2115 Val Trp Met Ala Asn Glu Leu Ser Arg Leu Val Asn Ser Pro Thr 2120 2125 2130 Val Arg Glu Tyr Val Lys Trp Gly Met Thr Lys Ile Val Ile Pro 2135 2140 2145 Ala Lys Leu Val Leu Leu Arg Asp Glu Lys Gln Glu Phe Val Ala 2150 2155 2160 Pro Lys Val Val Lys Ala Lys Val Ile Ala Cys Tyr Ser Ala Val 2165 2170 2175 Lys Trp Phe Phe Leu Tyr Cys Phe Ser Trp Ile Lys Phe Asn Thr 2180 2185 2190 Asp Asn Lys Val Ile Tyr Thr Thr Glu Val Ala Ser Lys Leu Thr 2195 2200 2205 Phe Asn Leu Cys Cys Leu Ala Phe Lys Asn Ala Leu Gln Thr Phe 2210 2215 2220 Asn Trp Asn Val Val Ser Arg Gly Phe Phe Leu Val Ala Thr Val 2225 2230 2235 Phe Leu Leu Trp Phe Asn Phe Leu Tyr Ala Asn Val Ile Leu Ser 2240 2245 2250 Asp Phe Tyr Leu Pro Asn Ile Gly Phe Phe Pro Thr Phe Val Gly 2255 2260 2265 Gln Ile Val Ala Trp Val Lys Thr Thr Phe Gly Ile Phe Thr Leu 2270 2275 2280 Cys Asp Leu Tyr Gln Val Ser Asp Val Gly Tyr Arg Ser Ser Phe 2285 2290 2295 Cys Asn Gly Ser Met Val Cys Glu Leu Cys Phe Ser Gly Phe Asp 2300 2305 2310 Met Leu Asp Asn Tyr Asp Ala Ile Asn Val Val Gln His Val Val 2315 2320 2325 Asp Arg Arg Val Ser Phe Asp Tyr Ile Ser Leu Phe Lys Leu Val 2330 2335 2340 Val Glu Leu Val Ile Gly Tyr Ser Leu Tyr Thr Val Cys Phe Tyr 2345 2350 2355 Pro Leu Phe Gly Leu Ile Gly Met Gln Leu Leu Thr Thr Trp Leu 2360 2365 2370 Pro Glu Phe Phe Met Leu Glu Thr Met His Trp Ser Ala Arg Phe 2375 2380 2385 Phe Val Phe Val Ala Asn Met Leu Pro Ala Phe Thr Leu Leu Arg 2390 2395 2400 Phe Tyr Ile Val Val Thr Ala Met Tyr Lys Ile Phe Cys Leu Cys 2405 2410 2415 Arg His Val Met Tyr Gly Cys Ser Arg Pro Gly Cys Leu Phe Cys 2420 2425 2430 Tyr Lys Arg Asn Arg Ser Val Arg Val Lys Cys Ser Thr Val Val 2435 2440 2445 Gly Gly Thr Leu Arg Tyr Tyr Asp Val Met Ala Asn Gly Gly Thr 2450 2455 2460 Gly Phe Cys Ala Lys His Gln Trp Asn Cys Leu Asn Cys Ser Ala 2465 2470 2475 Phe Gly Pro Gly Asn Thr Phe Ile Thr His Glu Ala Ala Ala Asp 2480 2485 2490 Leu Ser Lys Glu Leu Lys Arg Pro Val Asn Pro Thr Asp Ser Ala 2495 2500 2505 Tyr Tyr Leu Val Thr Glu Val Lys Gln Val Gly Cys Ser Met Arg 2510 2515 2520 Leu Phe Tyr Glu Arg Asp Gly Gln Arg Val Tyr Asp Asp Val Ser 2525 2530 2535 Ala Ser Leu Phe Val Asp Met Asn Gly Leu Leu His Ser Lys Val 2540 2545 2550 Lys Gly Val Pro Glu Thr His Val Val Val Val Glu Asn Glu Ala 2555 2560 2565 Asp Lys Ala Gly Phe Leu Asn Ala Ala Val Phe Tyr Ala Gln Ser 2570 2575 2580 Leu Tyr Arg Pro Met Leu Leu Val Glu Lys Lys Leu Ile Thr Thr 2585 2590 2595 Ala Asn Thr Gly Leu Ser Val Ser Gln Thr Met Phe Asp Leu Tyr 2600 2605 2610 Val Asp Ser Leu Leu Gly Val Leu Asp Val Asp Arg Lys Ser Leu 2615 2620 2625 Thr Ser Phe Val Asn Ala Ala His Asn Ser Leu Lys Glu Gly Val 2630 2635 2640 Gln Leu Glu Gln Val Met Asp Thr Phe Ile Gly Cys Ala Arg Arg 2645 2650 2655 Lys Cys Ala Ile Asp Ser Asp Val Glu Thr Lys Ser Ile Thr Lys 2660 2665 2670 Ser Ile Met Ser Ala Val Asn Ala Gly Val Asp Phe Thr Asp Glu 2675 2680 2685 Ser Cys Asn Asn Leu Val Pro Thr Tyr Val Lys Ser Asp Thr Ile 2690 2695 2700 Val Ala Ala Asp Leu Gly Val Leu Ile Gln Asn Asn Ala Lys His 2705 2710 2715 Val Gln Ala Asn Val Ala Lys Ala Ala Asn Val Ala Cys Ile Trp 2720 2725 2730 Ser Val Asp Ala Phe Asn Gln Leu Ser Ala Asp Leu Gln His Arg 2735 2740 2745 Leu Arg Lys Ala Cys Ser Lys Thr Gly Leu Lys Ile Lys Leu Thr 2750 2755 2760 Tyr Asn Lys Gln Glu Ala Asn Val Pro Ile Leu Thr Thr Pro Phe 2765 2770 2775 Ser Leu Lys Gly Gly Ala Val Phe Ser Lys Val Leu Gln Trp Leu 2780 2785 2790 Phe Val Val Asn Leu Ile Cys Phe Ile Val Leu Trp Ala Leu Met 2795 2800 2805 Pro Thr Tyr Ala Val His Lys Ser Asp Met Gln Leu Pro Leu Tyr 2810 2815 2820 Ala Ser Phe Lys Val Ile Asp Asn Gly Val Leu Arg Asp Val Thr 2825 2830 2835 Val Thr Asp Ala Cys Phe Ala Asn Lys Phe Ile Gln Phe Asp Gln 2840 2845 2850 Trp Tyr Glu Ser Thr Phe Gly Leu Val Tyr Tyr Arg Asn Ser Arg 2855 2860 2865 Ala Cys Pro Val Val Val Ala Val Ile Asp Gln Asp Ile Gly Tyr 2870 2875 2880 Thr Leu Phe Asn Val Pro Thr Lys Val Leu Arg Tyr Gly Phe His 2885 2890 2895 Val Leu His Phe Ile Thr His Ala Phe Ala Thr Asp Ser Val Gln 2900 2905 2910 Cys Tyr Thr Pro His Met Gln Ile Pro Tyr Asp Asn Phe Tyr Ala 2915 2920 2925 Ser Gly Cys Val Leu Ser Ser Leu Cys Thr Met Leu Ala His Ala 2930 2935 2940 Asp Gly Thr Pro His Pro Tyr Cys Tyr Thr Glu Gly Ile Met His 2945 2950 2955 Asn Ala Ser Leu Tyr Asp Ser Leu Ala Pro His Val Arg Tyr Asn 2960 2965 2970 Leu Ala Asn Ser Asn Gly Tyr Ile Arg Phe Pro Glu Val Val Ser 2975 2980 2985 Glu Gly Ile Val Arg Ile Val Arg Thr Arg Ser Met Thr Tyr Cys 2990 2995 3000 Arg Val Gly Leu Cys Glu Asp Ala Glu Glu Gly Val Cys Phe Asn 3005 3010 3015 Phe Asn Ser Ser Trp Val Leu Asn Asn Pro Tyr Tyr Arg Ala Met 3020 3025 3030 Pro Gly Thr Phe Cys Gly Arg Asn Ala Phe Asp Leu Ile His Gln 3035 3040 3045 Val Leu Gly Gly Leu Val Arg Pro Ile Asp Phe Phe Ala Leu Thr 3050 3055 3060 Ala Ser Ser Val Ala Gly Ala Ile Leu Ala Ile Ile Val Val Leu 3065 3070 3075 Ala Phe Tyr Tyr Leu Ile Lys Leu Lys Arg Ala Phe Gly Asp Tyr 3080 3085 3090 Thr Ser Val Val Val Ile Asn Val Ile Val Trp Cys Ile Asn Phe 3095 3100 3105 Leu Met Leu Phe Val Phe Gln Val Tyr Pro Thr Leu Ser Cys Leu 3110 3115 3120 Tyr Ala Cys Phe Tyr Phe Tyr Thr Thr Leu Tyr Phe Pro Ser Glu 3125 3130 3135 Ile Ser Val Val Met His Leu Gln Trp Leu Val Met Tyr Gly Ala 3140 3145 3150 Ile Met Pro Leu Trp Phe Cys Ile Ile Tyr Val Ala Val Val Val 3155 3160 3165 Ser Asn His Ala Leu Trp Leu Phe Ser Tyr Cys Arg Lys Leu Gly 3170 3175 3180 Thr Glu Val Arg Ser Asp Gly Thr Phe Glu Glu Met Ser Leu Thr 3185 3190 3195 Thr Phe Met Ile Thr Lys Glu Ser Tyr Cys Lys Leu Lys Asn Ser 3200 3205 3210 Val Ser Asp Val Ala Phe Asn Arg Tyr Leu Ser Leu Tyr Asn Lys 3215 3220 3225 Tyr Arg Tyr Phe Ser Gly Lys Met Asp Thr Ala Ala Tyr Arg Glu 3230 3235 3240 Ala Ala Cys Ser Gln Leu Ala Lys Ala Met Glu Thr Phe Asn His 3245 3250 3255 Asn Asn Gly Asn Asp Val Leu Tyr Gln Pro Pro Thr Ala Ser Val 3260 3265 3270 Thr Thr Ser Phe Leu Gln Ser Gly Ile Val Lys Met Val Phe Pro 3275 3280 3285 Thr Ser Lys Val Glu Pro Cys Val Val Ser Val Thr Tyr Gly Asn 3290 3295 3300 Met Thr Leu Asn Gly Leu Trp Leu Asp Asp Lys Val Tyr Cys Pro 3305 3310 3315 Arg His Val Ile Cys Ser Ser Ala Asp Met Thr Asp Pro Asp Tyr 3320 3325 3330 Ser Asn Leu Leu Cys Arg Val Ile Ser Ser Asp Phe Cys Val Met 3335 3340 3345 Ser Gly Arg Met Ser Leu Thr Val Met Ser Tyr Gln Met Gln Gly 3350 3355 3360 Ser Leu Leu Val Leu Thr Val Thr Leu Gln Asn Pro Asn Thr Pro 3365 3370 3375 Lys Tyr Ser Phe Gly Val Val Lys Pro Gly Glu Thr Phe Thr Val 3380 3385 3390 Leu Ala Ala Tyr Asn Gly Lys Ser Gln Gly Ala Phe His Val Thr 3395 3400 3405 Met Arg Ser Ser Tyr Thr Ile Lys Gly Ser Phe Leu Cys Gly Ser 3410 3415 3420 Cys Gly Ser Val Gly Tyr Val Leu Thr Gly Asp Ser Val Arg Phe 3425 3430 3435 Val Tyr Met His Gln Leu Glu Leu Ser Thr Gly Cys His Thr Gly 3440 3445 3450 Thr Asp Phe Ser Gly Asn Phe Tyr Gly Pro Tyr Arg Asp Ala Gln 3455 3460 3465 Val Val Gln Leu Pro Val Gln Asp Tyr Thr Gln Thr Val Asn Val 3470 3475 3480 Val Ala Trp Leu Tyr Ala Ala Ile Leu Asn Arg Cys Asn Trp Phe 3485 3490 3495 Val Gln Ser Asp Ser Cys Ser Leu Glu Glu Phe Asn Val Trp Ala 3500 3505 3510 Met Thr Asn Gly Phe Ser Ser Ile Lys Ala Asp Leu Val Leu Asp 3515 3520 3525 Ala Leu Ala Ser Met Thr Gly Val Thr Val Glu Gln Ile Leu Ala 3530 3535 3540 Ala Ile Lys Arg Leu Tyr Ser Gly Phe Gln Gly Lys Gln Ile Leu 3545 3550 3555 Gly Ser Cys Val Leu Glu Asp Glu Leu Thr Pro Ser Asp Val Tyr 3560 3565 3570 Gln Gln Leu Ala Gly Val Lys Leu Gln Ser Lys Arg Thr Arg Val 3575 3580 3585 Val Lys Gly Thr Cys Cys Trp Ile Leu Ala Ser Thr Leu Leu Phe 3590 3595 3600 Cys Ser Ile Ile Ser Ala Phe Val Lys Trp Thr Met Phe Met Tyr 3605 3610 3615 Val Thr Thr His Met Leu Gly Val Thr Leu Cys Ala Leu Cys Phe 3620 3625 3630 Val Ser Phe Ala Met Leu Leu Val Lys His Lys His Leu Tyr Leu 3635 3640 3645 Thr Met Phe Ile Met Pro Val Leu Cys Thr Leu Phe Tyr Thr Asn 3650 3655 3660 Tyr Leu Val Val Tyr Lys Gln Ser Phe Arg Gly Leu Ala Tyr Ala 3665 3670 3675 Trp Leu Ser His Phe Val Pro Ala Val Asp Tyr Thr Tyr Met Asp 3680 3685 3690 Glu Val Leu Tyr Gly Val Val Leu Leu Val Ala Met Val Phe Val 3695 3700 3705 Thr Met Arg Ser Ile Asn His Asp Val Phe Ser Val Met Phe Leu 3710 3715 3720 Val Gly Arg Leu Val Ser Leu Val Ser Met Trp Tyr Phe Gly Ala 3725 3730 3735 Asn Leu Glu Glu Glu Val Leu Leu Phe Leu Thr Ser Leu Phe Gly 3740 3745 3750 Thr Tyr Thr Trp Thr Thr Met Leu Ser Leu Ala Thr Ala Lys Val 3755 3760 3765 Ile Ala Lys Trp Leu Ala Val Asn Val Leu Tyr Phe Thr Asp Val 3770 3775 3780 Pro Gln Val Lys Leu Val Leu Leu Ser Tyr Leu Cys Ile Gly Tyr 3785 3790 3795 Val Cys Cys Cys Tyr Trp Gly Val Leu Ser Leu Leu Asn Ser Ile 3800 3805 3810 Phe Arg Met Pro Leu Gly Val Tyr Asn Tyr Lys Ile Ser Val Gln 3815 3820 3825 Glu Leu Arg Tyr Met Asn Ala Asn Gly Leu Arg Pro Pro Arg Asn 3830 3835 3840 Ser Phe Glu Ala Leu Val Leu Asn Phe Lys Leu Leu Gly Ile Gly 3845 3850 3855 Gly Val Pro Val Ile Glu Val Ser Gln Ile Gln Ser Arg Leu Thr 3860 3865 3870 Asp Val Lys Cys Val Asn Val Val Leu Leu Asn Cys Leu Gln His 3875 3880 3885 Leu His Ile Ala Ser Ser Ser Lys Leu Trp Gln Tyr Cys Ser Thr 3890 3895 3900 Leu His Asn Glu Ile Leu Ala Thr Ser Asp Leu Ser Val Ala Phe 3905 3910 3915 Asp Lys Leu Ala Gln Leu Leu Val Val Leu Phe Ala Asn Pro Ala 3920 3925 3930 Ala Val Asp Ser Lys Cys Leu Ala Ser Ile Glu Glu Val Ser Asp 3935 3940 3945 Asp Tyr Val Arg Asp Ser Thr Val Leu Gln Ala Leu Gln Ser Glu 3950 3955 3960 Phe Val Asn Met Ala Ser Phe Val Glu Tyr Glu Leu Ala Lys Lys 3965 3970 3975 Asn Leu Asp Glu Ala Lys Ala Ser Gly Ser Ala Asn Gln Gln Gln 3980 3985 3990 Ile Lys Gln Leu Glu Lys Ala Cys Asn Ile Ala Lys Ser Ala Tyr 3995 4000 4005 Glu Arg Asp Arg Ala Val Ala Arg Lys Leu Glu Arg Met Ala Asp 4010 4015 4020 Leu Ala Leu Thr Asn Met Tyr Lys Glu Ala Arg Ile Asn Asp Lys 4025 4030 4035 Lys Ser Lys Val Val Ser Ala Leu Gln Thr Met Leu Phe Ser Met 4040 4045 4050 Ile Arg Lys Leu Asp Asn Gln Ala Leu Asn Ser Ile Leu Asp Asn 4055 4060 4065 Ala Val Lys Gly Cys Val Pro Leu Asn Ala Ile Pro Ser Leu Thr 4070 4075 4080 Ser Asn Thr Leu Thr Ile Ile Val Pro Asp Lys Gln Val Phe Asp 4085 4090 4095 Gln Val Val Asp Asn Val Tyr Val Thr Tyr Ala Gly Asn Val Trp 4100 4105 4110 His Ile Gln Ser Ile Gln Asp Ala Asp Gly Ala Val Lys Gln Leu 4115 4120 4125 Asn Glu Ile Asp Val Asn Ile Thr Trp Pro Leu Val Ile Ala Ala 4130 4135 4140 Asn Arg His Asn Glu Val Ser Ser Val Val Leu Gln Asn Asn Glu 4145 4150 4155 Leu Met Pro Gln Lys Leu Arg Thr Gln Val Val Asn Ser Gly Ser 4160 4165 4170 Asp Met Asn Cys Asn Thr Pro Thr Gln Cys Tyr Tyr Asn Thr Thr 4175 4180 4185 Gly Met Gly Lys Ile Val Tyr Ala Ile Leu Ser Asp Cys Asp Gly 4190 4195 4200 Leu Lys Tyr Thr Lys Ile Val Lys Glu Asp Gly Asn Cys Val Val 4205 4210 4215 Leu Glu Leu Asp Pro Pro Cys Lys Phe Ser Val Gln Asp Val Lys 4220 4225 4230 Gly Leu Lys Ile Lys Tyr Leu Tyr Phe Val Lys Gly Cys Asn Thr 4235 4240 4245 Leu Ala Arg Gly Trp Val Val Gly Thr Leu Ser Ser Thr Val Arg 4250 4255 4260 Leu Gln Ala Gly Thr Ala Thr Glu Tyr Ala Ser Asn Ser Ala Ile 4265 4270 4275 Arg Ser Leu Cys Ala Phe Ser Val Asp Pro Lys Lys Thr Tyr Leu 4280 4285 4290 Asp Tyr Ile Gln Gln Gly Gly Ala Pro Val Thr Asn Cys Val Lys 4295 4300 4305 Met Leu Cys Asp His Ala Gly Thr Gly Met Ala Ile Thr Ile Lys 4310 4315 4320 Pro Glu Ala Thr Thr Asn Gln Asp Ser Tyr Gly Gly Ala Ser Val 4325 4330 4335 Cys Ile Tyr Cys Arg Ser Arg Val Glu His Pro Asp Val Asp Gly 4340 4345 4350 Leu Cys Lys Leu Arg Gly Lys Phe Val Gln Val Pro Leu Gly Ile 4355 4360 4365 Lys Asp Pro Val Ser Tyr Val Leu Thr His Asp Val Cys Gln Val 4370 4375 4380 Cys Gly Phe Trp Arg Asp Gly Met Phe Leu Cys Arg His Arg Leu 4385 4390 4395 Pro Val Ser Val Lys Arg His Glu Leu Phe Lys Arg Val Arg Gly 4400 4405 4410 Thr Ser Val Asn Ala Arg Leu Val Pro Cys Ala Ser Gly Leu Asp 4415 4420 4425 Thr Asp Val Gln Leu Arg Ala Phe Asp Ile Cys Asn Ala Asn Arg 4430 4435 4440 Ala Gly Ile Gly Leu Tyr Tyr Lys Val Asn Cys Cys Arg Phe Gln 4445 4450 4455 Arg Ala Asp Glu Asp Gly Asn Thr Leu Asp Lys Phe Phe Val Ile 4460 4465 4470 Lys Arg Thr Asn Leu Glu Val Tyr Asn Lys Glu Lys Glu Cys Tyr 4475 4480 4485 Glu Leu Thr Lys Glu Cys Gly Val Val Ala Glu His Glu Phe Phe 4490 4495 4500 Thr Phe Asp Val Glu Gly Ser Arg Val Pro His Ile Val Arg Lys 4505 4510 4515 Asp Leu Ser Lys Tyr Thr Met Leu Asp Leu Cys Tyr Ala Leu Arg 4520 4525 4530 His Phe Asp Arg Asn Asp Cys Ser Thr Leu Lys Glu Ile Leu Leu 4535 4540 4545 Thr Tyr Ala Glu Cys Asp Glu Ser Tyr Phe Gln Lys Lys Asp Trp 4550 4555 4560 Tyr Asp Phe Val Glu Asn Ser Asp Ile Ile Asn Val Tyr Lys Lys 4565 4570 4575 Leu Gly Pro Ile Phe Asn Arg Ala Leu Leu Asn Thr Ala Lys Phe 4580 4585 4590 Ala Asp Thr Leu Val Glu Ala Gly Leu Val Gly Val Leu Thr Leu 4595 4600 4605 Asp Asn Gln Asp Leu Tyr Gly Gln Trp Tyr Asp Phe Gly Asp Phe 4610 4615 4620 Val Lys Thr Val Pro Gly Cys Gly Val Ala Val Ala Asp Ser Tyr 4625 4630 4635 Tyr Ser Tyr Met Met Pro Met Leu Thr Met Cys His Ala Leu Asp 4640 4645 4650 Ser Glu Leu Phe Ile Asn Gly Thr Tyr Arg Glu Phe Asp Leu Val 4655 4660 4665 Gln Tyr Asp Phe Thr Asp Phe Lys Leu Glu Leu Phe Asn Lys Tyr 4670 4675 4680 Phe Lys Tyr Trp Ser Met Thr Tyr His Pro Asn Thr Cys Glu Cys 4685 4690 4695 Glu Asp Asp Arg Cys Ile Ile His Cys Ala Asn Phe Asn Ile Leu 4700 4705 4710 Phe Ser Met Val Leu Pro Lys Thr Cys Phe Gly Pro Leu Val Arg 4715 4720 4725 Gln Ile Phe Val Asp Gly Val Pro Phe Val Val Ser Ile Gly Tyr 4730 4735 4740 His Tyr Lys Glu Leu Gly Val Val Met Asn Met Asp Val Asp Thr 4745 4750 4755 His Arg Tyr Arg Leu Ser Leu Lys Asp Leu Leu Leu Tyr Ala Ala 4760 4765 4770 Asp Pro Ala Leu His Val Ala Ser Ala Ser Ala Leu Leu Asp Leu 4775 4780 4785 Arg Thr Cys Cys Phe Ser Val Ala Ala Ile Thr Ser Gly Val Lys 4790 4795 4800 Phe Gln Thr Val Lys Pro Gly Asn Phe Asn Gln Asp Phe Tyr Glu 4805 4810 4815 Phe Ile Leu Ser Lys Gly Leu Leu Lys Glu Gly Ser Ser Val Asp 4820 4825 4830 Leu Lys His Phe Phe Phe Thr Gln Asp Gly Asn Ala Ala Ile Thr 4835 4840 4845 Asp Tyr Asn Tyr Tyr Lys Tyr Asn Leu Pro Thr Met Val Asp Ile 4850 4855 4860 Lys Gln Leu Leu Phe Val Leu Glu Val Val Asn Lys Tyr Phe Glu 4865 4870 4875 Ile Tyr Asp Gly Gly Cys Ile Pro Ala Thr Gln Val Ile Val Asn 4880 4885 4890 Asn Tyr Asp Lys Ser Ala Gly Tyr Pro Phe Asn Lys Phe Gly Lys 4895 4900 4905 Ala Arg Leu Tyr Tyr Glu Ala Leu Ser Phe Glu Glu Gln Asp Glu 4910 4915 4920 Val Tyr Ala Tyr Thr Lys Arg Asn Val Leu Pro Thr Leu Thr Gln 4925 4930 4935 Met Asn Leu Lys Tyr Ala Ile Ser Ala Lys Asn Arg Ala Arg Thr 4940 4945 4950 Val Ala Gly Val Ser Ile Leu Ser Thr Met Thr Gly Arg Met Phe 4955 4960 4965 His Gln Lys Cys Leu Lys Ser Ile Ala Ala Thr Arg Gly Val Pro 4970 4975 4980 Val Val Ile Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asp Asp Met 4985 4990 4995 Leu Arg Arg Leu Ile Lys Asp Val Asp Ser Pro Val Leu Met Gly 5000 5005 5010 Trp Asp Tyr Pro Lys Cys Asp Arg Ala Met Pro Asn Ile Leu Arg 5015 5020 5025 Ile Ile Ser Ser Leu Val Leu Ala Arg Lys His Asp Ser Cys Cys 5030 5035 5040 Ser His Thr Asp Arg Phe Tyr Arg Leu Ala Asn Glu Cys Ala Gln 5045 5050 5055 Val Leu Ser Glu Ile Val Met Cys Gly Gly Cys Tyr Tyr Val Lys 5060 5065 5070 Pro Gly Gly Thr Ser Ser Gly Asp Ala Thr Thr Ala Phe Ala Asn 5075 5080 5085 Ser Val Phe Asn Ile Cys Gln Ala Val Ser Ala Asn Val Cys Ser 5090 5095 5100 Leu Met Ala Cys Asn Gly His Lys Ile Glu Asp Leu Ser Ile Arg 5105 5110 5115 Glu Leu Gln Lys Arg Leu Tyr Ser Asn Val Tyr Arg Ala Asp His 5120 5125 5130 Val Asp Pro Ala Phe Val Asn Glu Tyr Tyr Glu Phe Leu Asn Lys 5135 5140 5145 His Phe Ser Met Met Ile Leu Ser Asp Asp Gly Val Val Cys Tyr 5150 5155 5160 Asn Ser Glu Phe Ala Ser Lys Gly Tyr Ile Ala Asn Ile Ser Ala 5165 5170 5175 Phe Gln Gln Val Leu Tyr Tyr Gln Asn Asn Val Phe Met Ser Glu 5180 5185 5190 Ala Lys Cys Trp Val Glu Thr Asp Ile Glu Lys Gly Pro His Glu 5195 5200 5205 Phe Cys Ser Gln His Thr Met Leu Val Lys Met Asp Gly Asp Glu 5210 5215 5220 Val Tyr Leu Pro Tyr Pro Asp Pro Ser Arg Ile Leu Gly Ala Gly 5225 5230 5235 Cys Phe Val Asp Asp Leu Leu Lys Thr Asp Ser Val Leu Leu Ile 5240 5245 5250 Glu Arg Phe Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu Val Tyr 5255 5260 5265 His Glu Asn Pro Glu Tyr Gln Asn Val Phe Arg Val Tyr Leu Glu 5270 5275 5280 Tyr Ile Lys Lys Leu Tyr Asn Asp Leu Gly Asn Gln Ile Leu Asp 5285 5290 5295 Ser Tyr Ser Val Ile Leu Ser Thr Cys Asp Gly Gln Lys Phe Thr 5300 5305 5310 Asp Glu Thr Phe Tyr Lys Asn Met Tyr Leu Arg Ser Ala Val Met 5315 5320 5325 Gln Ser Val Gly Ala Cys Val Val Cys Ser Ser Gln Thr Ser Leu 5330 5335 5340 Arg Cys Gly Ser Cys Ile Arg Lys Pro Leu Leu Cys Cys Lys Cys 5345 5350 5355 Ala Tyr Asp His Val Met Ser Thr Asp His Lys Tyr Val Leu Ser 5360 5365 5370 Val Ser Pro Tyr Val Cys Asn Ser Pro Gly Cys Asp Val Asn Asp 5375 5380 5385 Val Thr Lys Leu Tyr Leu Gly Gly Met Ser Tyr Tyr Cys Glu Asp 5390 5395 5400 His Lys Pro Gln Tyr Ser Phe Lys Leu Val Met Asn Gly Met Val 5405 5410 5415 Phe Gly Leu Tyr Lys Gln Ser Cys Thr Gly Ser Pro Tyr Ile Glu 5420 5425 5430 Asp Phe Asn Lys Ile Ala Ser Cys Lys Trp Thr Glu Val Asp Asp 5435 5440 5445 Tyr Val Leu Ala Asn Glu Cys Thr Glu Arg Leu Lys Leu Phe Ala 5450 5455 5460 Ala Glu Thr Gln Lys Ala Thr Glu Glu Ser Phe Lys Gln Cys Tyr 5465 5470 5475 Ala Ser Ala Thr Ile Arg Glu Ile Val Ser Asp Arg Glu Leu Ile 5480 5485 5490 Leu Ser Trp Glu Ile Gly Lys Val Arg Pro Pro Leu Asn Lys Asn 5495 5500 5505 Tyr Val Phe Thr Gly Tyr His Phe Thr Ser Asn Gly Lys Thr Val 5510 5515 5520 Leu Gly Glu Tyr Val Phe Asp Lys Ser Glu Leu Thr Asn Gly Val 5525 5530 5535 Tyr Tyr Arg Ala Thr Thr Thr Tyr Lys Leu Ser Val Gly Asp Val 5540 5545 5550 Phe Ile Leu Thr Ser His Ala Val Ser Ser Leu Ser Ala Pro Thr 5555 5560 5565 Leu Val Pro Gln Glu Asn Tyr Thr Ser Ile Arg Phe Ala Ser Val 5570 5575 5580 Tyr Ser Val Pro Glu Thr Phe Gln Asn Asn Val Pro Asn Tyr Gln 5585 5590 5595 His Ile Gly Met Lys Arg Tyr Cys Thr Val Gln Gly Pro Pro Gly 5600 5605 5610 Thr Gly Lys Ser His Leu Ala Ile Gly Leu Ala Val Tyr Tyr Cys 5615 5620 5625 Thr Ala Arg Val Val Tyr Thr Ala Ala Ser His Ala Ala Val Asp 5630 5635 5640 Ala Leu Cys Glu Lys Ala Tyr Lys Phe Leu Asn Ile Asn Asp Cys 5645 5650 5655 Thr Arg Ile Val Pro Ala Lys Val Arg Val Asp Cys Tyr Asp Lys 5660 5665 5670 Phe Lys Val Asn Asp Thr Thr Arg Lys Tyr Val Phe Thr Thr Ile 5675 5680 5685 Asn Ala Leu Pro Glu Leu Val Thr Asp Ile Ile Val Val Asp Glu 5690 5695 5700 Val Ser Met Leu Thr Asn Tyr Glu Leu Ser Val Ile Asn Ser Arg 5705 5710 5715 Val Arg Ala Lys His Tyr Val Tyr Ile Gly Asp Pro Ala Gln Leu 5720 5725 5730 Pro Ala Pro Arg Val Leu Leu Asn Lys Gly Thr Leu Glu Pro Arg 5735 5740 5745 Tyr Phe Asn Ser Val Thr Lys Leu Met Cys Cys Leu Gly Pro Asp 5750 5755 5760 Ile Phe Leu Gly Thr Cys Tyr Arg Cys Pro Lys Glu Ile Val Asp 5765 5770 5775 Thr Val Ser Ala Leu Val Tyr His Asn Lys Leu Lys Ala Lys Asn 5780 5785 5790 Asp Asn Ser Ser Met Cys Phe Lys Val Tyr Tyr Lys Gly Gln Thr 5795 5800 5805 Thr His Glu Ser Ser Ser Ala Val Asn Met Gln Gln Ile Tyr Leu 5810 5815 5820 Ile Ser Lys Phe Leu Lys Ala Asn Pro Ser Trp Ser Asn Ala Val 5825 5830 5835 Phe Ile Ser Pro Tyr Asn Ser Gln Asn Tyr Val Ala Lys Arg Val 5840 5845 5850 Leu Gly Leu Gln Thr Gln Thr Val Asp Ser Ala Gln Gly Ser Glu 5855 5860 5865 Tyr Asp Phe Val Ile Tyr Ser Gln Thr Ala Glu Thr Ala His Ser 5870 5875 5880 Val Asn Val Asn Arg Phe Asn Val Ala Ile Thr Arg Ala Lys Lys 5885 5890 5895 Gly Ile Leu Cys Val Met Ser Ser Met Gln Leu Phe Glu Ser Leu 5900 5905 5910 Asn Phe Ser Thr Leu Thr Leu Asp Lys Ile Asn Asn Pro Arg Leu 5915 5920 5925 Gln Cys Thr Thr Asn Leu Phe Lys Asp Cys Ser Arg Ser Tyr Ala 5930 5935 5940 Gly Tyr His Pro Ala His Ala Pro Ser Phe Leu Ala Val Asp Asp 5945 5950 5955 Lys Tyr Lys Val Gly Gly Asp Leu Ala Val Cys Leu Asn Val Ala 5960 5965 5970 Asp Ser Ala Val Thr Tyr Ser Arg Leu Ile Ser Leu Met Gly Phe 5975 5980 5985 Lys Leu Asp Leu Thr Leu Asp Gly Tyr Cys Lys Leu Phe Ile Thr 5990 5995 6000 Arg Asp Glu Ala Ile Arg Arg Val Arg Ala Trp Val Gly Phe Asp 6005 6010 6015 Ala Glu Gly Ala His Ala Thr Arg Asp Ser Ile Gly Thr Asn Phe 6020 6025 6030 Pro Leu Gln Leu Gly Phe Ser Thr Gly Ile Asp Phe Val Val Glu 6035 6040 6045 Ala Thr Gly Met Phe Ala Glu Arg Asp Gly Tyr Val Phe Lys Lys 6050 6055 6060 Ala Val Ala Arg Ala Pro Pro Gly Glu Gln Phe Lys His Leu Val 6065 6070 6075 Pro Leu Met Ser Arg Gly Gln Lys Trp Asp Val Val Arg Ile Arg 6080 6085 6090 Ile Val Gln Met Leu Ser Asp His Leu Val Asp Leu Ala Asp Ser 6095 6100 6105 Val Val Leu Val Thr Trp Ala Ala Ser Phe Glu Leu Thr Cys Leu 6110 6115 6120 Arg Tyr Phe Ala Lys Val Gly Lys Glu Val Val Cys Ser Val Cys 6125 6130 6135 Asn Lys Arg Ala Thr Cys Phe Asn Ser Arg Thr Gly Tyr Tyr Gly 6140 6145 6150 Cys Trp Arg His Ser Tyr Ser Cys Asp Tyr Leu Tyr Asn Pro Leu 6155 6160 6165 Ile Val Asp Ile Gln Gln Trp Gly Tyr Thr Gly Ser Leu Thr Ser 6170 6175 6180 Asn His Asp Leu Ile Cys Ser Val His Lys Gly Ala His Val Ala 6185 6190 6195 Ser Ser Asp Ala Ile Met Thr Arg Cys Leu Ala Val His Asp Cys 6200 6205 6210 Phe Cys Lys Ser Val Asn Trp Ser Leu Glu Tyr Pro Ile Ile Ser 6215 6220 6225 Asn Glu Val Ser Val Asn Thr Ser Cys Arg Leu Leu Gln Arg Val 6230 6235 6240 Met Phe Arg Ala Ala Met Leu Cys Asn Arg Tyr Asp Val Cys Tyr 6245 6250 6255 Asp Ile Gly Asn Pro Lys Gly Leu Ala Cys Val Lys Gly Tyr Asp 6260 6265 6270 Phe Lys Phe Tyr Asp Ala Ser Pro Val Val Lys Ser Val Lys Gln 6275 6280 6285 Phe Val Tyr Lys Tyr Glu Ala His Lys Asp Gln Phe Leu Asp Gly 6290 6295 6300 Leu Cys Met Phe Trp Asn Cys Asn Val Asp Lys Tyr Pro Ala Asn 6305 6310 6315 Ala Val Val Cys Arg Phe Asp Thr Arg Val Leu Asn Lys Leu Asn 6320 6325 6330 Leu Pro Gly Cys Asn Gly Gly Ser Leu Tyr Val Asn Lys His Ala 6335 6340 6345 Phe His Thr Ser Pro Phe Thr Arg Ala Ala Phe Glu Asn Leu Lys 6350 6355 6360 Pro Met Pro Phe Phe Tyr Tyr Ser Asp Thr Pro Cys Val Tyr Met 6365 6370 6375 Glu Gly Met Glu Ser Lys Gln Val Asp Tyr Val Pro Leu Arg Ser 6380 6385 6390 Ala Thr Cys Ile Thr Arg Cys Asn Leu Gly Gly Ala Val Cys Leu 6395 6400 6405 Lys His Ala Glu Asp Tyr Arg Glu Tyr Leu Glu Ser Tyr Asn Thr 6410 6415 6420 Ala Thr Thr Ala Gly Phe Thr Phe Trp Val Tyr Lys Thr Phe Asp 6425 6430 6435 Phe Tyr Asn Leu Trp Asn Thr Phe Thr Arg Leu Gln Ser Leu Glu 6440 6445 6450 Asn Val Val Tyr Asn Leu Val Asn Ala Gly His Phe Asp Gly Arg 6455 6460 6465 Ala Gly Glu Leu Pro Cys Ala Val Ile Gly Glu Lys Val Ile Ala 6470 6475 6480 Lys Ile Gln Asn Glu Asp Val Val Val Phe Lys Asn Asn Thr Pro 6485 6490 6495 Phe Pro Thr Asn Val Ala Val Glu Leu Phe Ala Lys Arg Ser Ile 6500 6505 6510 Arg Pro His Pro Glu Leu Lys Leu Phe Arg Asn Leu Asn Ile Asp 6515 6520 6525 Val Cys Trp Ser His Val Leu Trp Asp Tyr Ala Lys Asp Ser Val 6530 6535 6540 Phe Cys Ser Ser Thr Tyr Lys Val Cys Lys Tyr Thr Asp Leu Gln 6545 6550 6555 Cys Ile Glu Ser Leu Asn Val Leu Phe Asp Gly Arg Asp Asn Gly 6560 6565 6570 Ala Leu Glu Ala Phe Lys Lys Cys Arg Asp Gly Val Tyr Ile Asn 6575 6580 6585 Thr Thr Lys Ile Lys Ser Leu Ser Met Ile Lys Gly Pro Gln Arg 6590 6595 6600 Ala Asp Leu Asn Gly Val Val Val Glu Lys Val Gly Asp Ser Asp 6605 6610 6615 Val Glu Phe Trp Phe Ala Met Arg Arg Asp Gly Asp Asp Val Ile 6620 6625 6630 Phe Ser Arg Thr Gly Ser Leu Glu Pro Ser His Tyr Arg Ser Pro 6635 6640 6645 Gln Gly Asn Pro Gly Gly Asn Arg Val Gly Asp Leu Ser Gly Asn 6650 6655 6660 Glu Ala Leu Ala Arg Gly Thr Ile Phe Thr Gln Ser Arg Phe Leu 6665 6670 6675 Ser Ser Phe Ala Pro Arg Ser Glu Met Glu Lys Asp Phe Met Asp 6680 6685 6690 Leu Asp Glu Asp Val Phe Ile Ala Lys Tyr Ser Leu Gln Asp Tyr 6695 6700 6705 Ala Phe Glu His Val Val Tyr Gly Ser Phe Asn Gln Lys Ile Ile 6710 6715 6720 Gly Gly Leu His Leu Leu Ile Gly Leu Ala Arg Arg Gln Gln Lys 6725 6730 6735 Ser Asn Leu Val Ile Gln Glu Phe Val Pro Tyr Asp Ser Ser Ile 6740 6745 6750 His Ser Tyr Phe Ile Thr Asp Glu Asn Ser Gly Ser Ser Lys Ser 6755 6760 6765 Val Cys Thr Val Ile Asp Leu Leu Leu Asp Asp Phe Val Asp Ile 6770 6775 6780 Val Lys Ser Leu Asn Leu Asn Cys Val Ser Lys Val Val Asn Val 6785 6790 6795 Asn Val Asp Phe Lys Asp Phe Gln Phe Met Leu Trp Cys Asn Glu 6800 6805 6810 Glu Lys Val Met Thr Phe Tyr Pro Arg Leu Gln Ala Ala Ala Asp 6815 6820 6825 Trp Lys Pro Gly Tyr Val Met Pro Val Leu Tyr Lys Tyr Leu Glu 6830 6835 6840 Ser Pro Leu Glu Arg Val Asn Leu Trp Asn Tyr Gly Lys Pro Ile 6845 6850 6855 Thr Leu Pro Thr Gly Cys Leu Met Asn Val Ala Lys Tyr Thr Gln 6860 6865 6870 Leu Cys Gln Tyr Leu Asn Thr Thr Thr Leu Ala Val Pro Ala Asn 6875 6880 6885 Met Arg Val Leu His Leu Gly Ala Gly Ser Asp Lys Asp Val Ala 6890 6895 6900 Pro Gly Ser Ala Val Leu Arg Gln Trp Leu Pro Ala Gly Ser Ile 6905 6910 6915 Leu Val Asp Asn Asp Ile Asn Pro Phe Val Ser Asp Ser Val Ala 6920 6925 6930 Ser Tyr Tyr Gly Asn Cys Ile Thr Leu Pro Ile Ala Cys Gln Trp 6935 6940 6945 Asp Leu Ile Ile Ser Asp Met Tyr Asp Pro Leu Thr Lys Asn Ile 6950 6955 6960 Gly Glu Tyr Asn Val Ser Lys Asp Gly Phe Phe Thr Tyr Leu Cys 6965 6970 6975 His Leu Ile Arg Asp Lys Leu Ala Leu Gly Gly Ser Val Ala Ile 6980 6985 6990 Lys Ile Thr Glu Phe Ser Trp Asn Ala Glu Leu Tyr Ser Leu Met 6995 7000 7005 Gly Lys Phe Ala Phe Trp Thr Ile Phe Cys Thr Asn Val Asn Ala 7010 7015 7020 Ser Ser Ser Glu Gly Phe Leu Ile Gly Ile Asn Trp Leu Asn Arg 7025 7030 7035 Thr Arg Thr Glu Ile Asp Gly Lys Thr Met His Ala Asn Tyr Leu 7040 7045 7050 Phe Trp Arg Asn Ser Thr Met Trp Asn Gly Gly Ala Tyr Ser Leu 7055 7060 7065 Phe Asp Met Ser Lys Phe Pro Leu Lys Val Ala Gly Thr Ala Val 7070 7075 7080 Val Ser Leu Lys Pro Asp Gln Ile Asn Asp Leu Val Leu Ser Leu 7085 7090 7095 Ile Glu Lys Gly Lys Leu Leu Val Arg Asp Thr Arg Lys Glu Val 7100 7105 7110 Phe Val Gly Asp Ser Leu Val Asn Val Lys 7115 7120 <210> 25 <211> 7095 <212> PRT <213> human coronavirus OC43 <220> <221> MISC_FEATURE <223> ORF 1AB <400> 25 Met Ser Lys Ile Asn Lys Tyr Gly Leu Glu Leu His Trp Ala Pro Glu 1 5 10 15 Phe Pro Trp Met Phe Glu Asp Ala Glu Glu Lys Leu Asp Asn Pro Ser 20 25 30 Ser Ser Glu Val Asp Met Ile Cys Ser Thr Thr Ala Gln Lys Leu Glu 35 40 45 Thr Asp Gly Ile Cys Pro Glu Asn His Val Met Val Asp Cys Arg Arg 50 55 60 Leu Leu Lys Gln Glu Cys Cys Val Gln Ser Ser Leu Ile Arg Glu Ile 65 70 75 80 Val Met Asn Ala Ser Pro Tyr Asp Leu Glu Val Leu Leu Gln Asp Ala 85 90 95 Leu Gln Ser Arg Glu Ala Val Leu Val Thr Thr Pro Leu Gly Met Ser 100 105 110 Leu Glu Ala Cys Tyr Val Arg Gly Cys Asn Pro Lys Gly Trp Thr Met 115 120 125 Gly Leu Phe Arg Arg Arg Ser Val Cys Asn Thr Gly Arg Cys Thr Val 130 135 140 Asn Lys His Val Ala Tyr Gln Leu Tyr Met Ile Asp Pro Ala Gly Val 145 150 155 160 Cys Leu Gly Ala Gly Gln Phe Val Gly Trp Val Ile Pro Leu Ala Phe 165 170 175 Met Pro Val Gln Ser Arg Lys Phe Ile Val Pro Trp Val Met Tyr Leu 180 185 190 Arg Lys Arg Gly Glu Lys Gly Ala Tyr Asn Lys Asp His Gly Arg Gly 195 200 205 Gly Phe Gly His Val Tyr Asp Phe Lys Val Glu Asp Ala Tyr Asp Gln 210 215 220 Val His Asp Glu Pro Lys Gly Lys Phe Ser Lys Lys Ala Tyr Ala Leu 225 230 235 240 Ile Arg Gly Tyr Arg Gly Val Lys Pro Leu Leu Tyr Val Asp Gln Tyr 245 250 255 Gly Cys Asp Tyr Thr Gly Ser Leu Ala Asp Gly Leu Glu Ala Tyr Ala 260 265 270 Asp Lys Thr Leu Gln Glu Met Lys Ala Leu Phe Pro Thr Trp Ser Gln 275 280 285 Glu Leu Leu Phe Asp Val Ile Val Ala Trp His Val Val Arg Asp Pro 290 295 300 Arg Tyr Val Met Arg Leu Gln Ser Ala Ala Thr Ile Arg Ser Val Ala 305 310 315 320 Tyr Val Ala Asn Pro Thr Glu Asp Leu Cys Asp Gly Ser Val Val Ile 325 330 335 Lys Glu Pro Val His Val Tyr Ala Asp Asp Ser Ile Ile Leu Arg Gln 340 345 350 Tyr Asn Leu Val Asp Ile Met Ser His Phe Tyr Met Glu Ala Asp Thr 355 360 365 Val Val Asn Ala Phe Tyr Gly Val Ala Leu Lys Asp Cys Gly Phe Val 370 375 380 Met Gln Phe Gly Tyr Ile Asp Cys Glu Gln Asp Ser Cys Asp Phe Lys 385 390 395 400 Gly Trp Ile Pro Gly Asn Met Ile Asp Gly Phe Ala Cys Thr Thr Cys 405 410 415 Gly His Val Tyr Glu Val Gly Asp Leu Ile Ala Gln Ser Ser Gly Val 420 425 430 Leu Pro Val Asn Pro Val Leu His Thr Lys Ser Ala Ala Gly Tyr Gly 435 440 445 Gly Phe Gly Cys Lys Asp Ser Phe Thr Leu Tyr Gly Gln Thr Val Val 450 455 460 Tyr Phe Gly Gly Cys Val Tyr Trp Ser Pro Ala Arg Asn Ile Trp Ile 465 470 475 480 Pro Ile Leu Lys Ser Ser Val Lys Ser Tyr Asp Ser Leu Val Tyr Thr 485 490 495 Gly Val Leu Gly Cys Lys Ala Ile Val Lys Glu Thr Asn Leu Ile Cys 500 505 510 Lys Ala Leu Tyr Leu Asp Tyr Val Gln His Lys Cys Gly Asn Leu His 515 520 525 Gln Arg Glu Leu Leu Gly Val Ser Asp Val Trp His Lys Gln Leu Leu 530 535 540 Leu Asn Arg Gly Val Tyr Lys Pro Leu Leu Glu Asn Ile Asp Tyr Phe 545 550 555 560 Asn Met Arg Arg Ala Lys Phe Ser Leu Glu Thr Phe Thr Val Cys Ala 565 570 575 Asp Gly Phe Met Pro Phe Leu Leu Asp Asp Leu Val Pro Arg Ala Tyr 580 585 590 Tyr Leu Ala Val Ser Gly Gln Ala Phe Cys Asp Tyr Ala Asp Lys Leu 595 600 605 Cys His Ala Val Val Ser Lys Ser Lys Glu Leu Leu Asp Val Ser Leu 610 615 620 Asp Ser Leu Gly Ala Ala Ile His Tyr Leu Asn Ser Lys Ile Val Asp 625 630 635 640 Leu Ala Gln His Phe Ser Asp Phe Gly Thr Ser Phe Val Ser Lys Ile 645 650 655 Val His Phe Phe Lys Thr Phe Thr Thr Ser Thr Ala Leu Ala Phe Ala 660 665 670 Trp Val Leu Phe His Val Leu His Gly Ala Tyr Ile Val Val Glu Ser 675 680 685 Asp Ile Tyr Phe Val Lys Asn Ile Pro Arg Tyr Ala Ser Ala Val Ala 690 695 700 Gln Ala Phe Gln Ser Val Ala Lys Val Val Leu Asp Ser Leu Arg Val 705 710 715 720 Thr Phe Ile Asp Gly Leu Ser Cys Phe Lys Ile Gly Arg Arg Arg Ile 725 730 735 Cys Leu Ser Gly Arg Lys Ile Tyr Glu Val Glu Arg Gly Leu Leu His 740 745 750 Ser Ser Gln Leu Pro Leu Asp Val Tyr Asp Leu Thr Met Pro Ser Gln 755 760 765 Val Gln Lys Ala Lys Gln Lys Pro Ile Tyr Leu Lys Gly Ser Gly Ser 770 775 780 Asp Phe Ser Leu Ala Asp Ser Val Val Glu Val Val Thr Thr Ser Leu 785 790 795 800 Thr Pro Cys Gly Tyr Ser Glu Pro Pro Lys Val Ala Asp Lys Ile Cys 805 810 815 Ile Val Asp Asn Val Tyr Met Ala Lys Ala Gly Asp Lys Tyr Tyr Pro 820 825 830 Val Val Val Asp Asp His Val Gly Leu Leu Asp Gln Ala Trp Arg Val 835 840 845 Pro Cys Ala Gly Arg Arg Val Thr Phe Lys Glu Gln Pro Thr Val Lys 850 855 860 Glu Ile Ile Ser Met Pro Lys Ile Ile Lys Val Phe Tyr Glu Leu Asp 865 870 875 880 Asn Asp Phe Asn Thr Ile Leu Asn Thr Ala Cys Gly Val Phe Glu Val 885 890 895 Asp Asp Thr Val Asp Met Glu Glu Phe Tyr Ala Val Val Ile Asp Ala 900 905 910 Ile Glu Glu Lys Leu Ser Pro Cys Lys Glu Leu Glu Gly Val Gly Ala 915 920 925 Lys Val Ser Ala Phe Leu Gln Lys Leu Glu Asp Asn Pro Leu Phe Leu 930 935 940 Phe Asp Glu Ala Gly Glu Glu Val Leu Ala Pro Lys Leu Tyr Cys Ala 945 950 955 960 Phe Thr Ala Pro Glu Asp Asp Asp Phe Leu Glu Glu Ser Asp Val Glu 965 970 975 Glu Asp Asp Val Glu Gly Glu Glu Thr Asp Leu Thr Val Thr Ser Ala 980 985 990 Gly Gln Pro Cys Val Ala Ser Glu Gln Glu Glu Ser Ser Glu Val Leu 995 1000 1005 Glu Asp Thr Leu Asp Asp Gly Pro Ser Val Glu Thr Ser Asp Ser 1010 1015 1020 Gln Val Glu Glu Asp Val Glu Met Ser Asp Phe Val Asp Leu Glu 1025 1030 1035 Ser Val Ile Gln Asp Tyr Glu Asn Val Cys Phe Glu Phe Tyr Thr 1040 1045 1050 Thr Glu Pro Glu Phe Val Lys Val Leu Gly Leu Tyr Val Pro Lys 1055 1060 1065 Ala Thr Arg Asn Asn Cys Trp Leu Arg Ser Val Leu Ala Val Met 1070 1075 1080 Gln Lys Leu Pro Cys Gln Phe Lys Asp Lys Asn Leu Gln Asp Leu 1085 1090 1095 Trp Val Leu Tyr Lys Gln Gln Tyr Ser Gln Leu Phe Val Asp Thr 1100 1105 1110 Leu Val Asn Lys Ile Pro Ala Asn Ile Val Leu Pro Gln Gly Gly 1115 1120 1125 Tyr Val Ala Asp Phe Ala Tyr Trp Phe Leu Thr Leu Cys Asp Trp 1130 1135 1140 Gln Cys Val Ala Tyr Trp Lys Cys Ile Lys Cys Asp Leu Ala Leu 1145 1150 1155 Lys Leu Lys Gly Leu Asp Ala Met Phe Phe Tyr Gly Asp Val Val 1160 1165 1170 Ser His Ile Cys Lys Cys Gly Glu Ser Met Val Leu Ile Asp Val 1175 1180 1185 Asp Val Pro Phe Thr Ala His Phe Ala Leu Lys Asp Lys Leu Phe 1190 1195 1200 Cys Ala Phe Ile Thr Lys Arg Ile Val Tyr Lys Ala Ala Cys Val 1205 1210 1215 Val Asp Val Asn Asp Ser His Ser Met Ala Val Val Asp Gly Lys 1220 1225 1230 Gln Ile Asp Asp His Arg Ile Thr Ser Ile Thr Ser Asp Lys Phe 1235 1240 1245 Asp Phe Ile Ile Gly His Gly Met Ser Phe Ser Met Thr Thr Phe 1250 1255 1260 Glu Ile Ala Gln Leu Tyr Gly Ser Cys Ile Thr Pro Asn Val Cys 1265 1270 1275 Phe Val Lys Gly Asp Ile Ile Lys Val Ser Lys Leu Val Lys Ala 1280 1285 1290 Glu Val Val Val Asn Pro Ala Asn Gly His Met Ala His Gly Gly 1295 1300 1305 Gly Val Ala Lys Ala Ile Ala Val Ala Ala Gly Gln Gln Phe Val 1310 1315 1320 Lys Glu Thr Thr Asp Met Val Lys Ser Lys Gly Val Cys Ala Thr 1325 1330 1335 Gly Asp Cys Tyr Val Ser Thr Gly Gly Lys Leu Cys Lys Thr Val 1340 1345 1350 Leu Asn Val Val Gly Pro Asp Ala Arg Thr Gln Gly Lys Gln Ser 1355 1360 1365 Tyr Val Leu Leu Glu Arg Val Tyr Lys His Leu Asn Asn Tyr Asp 1370 1375 1380 Cys Val Val Thr Thr Leu Ile Ser Ala Gly Ile Phe Ser Val Pro 1385 1390 1395 Ser Asp Val Ser Leu Thr Tyr Leu Leu Gly Thr Ala Lys Lys Gln 1400 1405 1410 Val Val Leu Val Ser Asn Asn Gln Glu Asp Phe Asp Leu Ile Ser 1415 1420 1425 Lys Cys Gln Ile Thr Ala Val Glu Gly Thr Lys Lys Leu Ala Ala 1430 1435 1440 Arg Leu Ser Phe Asn Val Gly Arg Ser Ile Val Tyr Glu Thr Asp 1445 1450 1455 Ala Asn Lys Leu Ile Leu Ile Asn Asp Val Ala Phe Val Ser Thr 1460 1465 1470 Phe Asn Val Leu Gln Asp Val Leu Ser Leu Arg His Asp Ile Ala 1475 1480 1485 Leu Asp Asp Asp Ala Arg Thr Phe Val Gln Ser Asn Val Asp Val 1490 1495 1500 Val Pro Glu Gly Trp Arg Val Val Asn Lys Phe Tyr Gln Ile Asn 1505 1510 1515 Gly Val Arg Thr Val Lys Tyr Phe Glu Cys Thr Gly Gly Ile Asp 1520 1525 1530 Ile Cys Ser Gln Asp Lys Val Phe Gly Tyr Val Gln Gln Gly Ile 1535 1540 1545 Phe Asn Lys Ala Thr Val Ala Gln Ile Lys Ala Leu Phe Leu Asp 1550 1555 1560 Lys Val Asp Ile Leu Leu Thr Val Asp Gly Val Asn Phe Thr Asn 1565 1570 1575 Arg Phe Val Pro Val Gly Glu Ser Phe Gly Lys Ser Leu Gly Asn 1580 1585 1590 Val Phe Cys Asp Gly Val Asn Val Thr Lys His Lys Cys Asp Ile 1595 1600 1605 Asn Tyr Lys Gly Lys Val Phe Phe Gln Phe Asp Asn Leu Ser Ser 1610 1615 1620 Glu Asp Leu Lys Ala Val Arg Ser Ser Phe Asn Phe Asp Gln Lys 1625 1630 1635 Glu Leu Leu Ala Tyr Tyr Asn Met Leu Val Asn Cys Phe Lys Trp 1640 1645 1650 Gln Val Val Val Asn Gly Lys Tyr Phe Thr Phe Lys Gln Ala Asn 1655 1660 1665 Asn Asn Cys Phe Val Asn Val Ser Cys Leu Met Leu Gln Ser Leu 1670 1675 1680 His Leu Thr Phe Lys Ile Val Gln Trp Gln Glu Ala Trp Leu Glu 1685 1690 1695 Phe Arg Ser Gly Arg Pro Ala Arg Phe Val Ala Leu Val Leu Ala 1700 1705 1710 Lys Gly Gly Phe Lys Phe Gly Asp Pro Ala Asp Ser Arg Asp Phe 1715 1720 1725 Leu Arg Val Val Phe Ser Gln Val Asp Leu Thr Gly Ala Ile Cys 1730 1735 1740 Asp Phe Glu Ile Ala Cys Lys Cys Gly Val Lys Gln Glu Gln Arg 1745 1750 1755 Thr Gly Leu Asp Ala Val Met His Phe Gly Thr Leu Ser Arg Glu 1760 1765 1770 Asp Leu Glu Ile Gly Tyr Thr Val Asp Cys Ser Cys Gly Lys Lys 1775 1780 1785 Leu Ile His Cys Val Arg Phe Asp Val Pro Phe Leu Ile Cys Ser 1790 1795 1800 Asn Thr Pro Ala Ser Val Lys Leu Pro Lys Gly Val Gly Ser Ala 1805 1810 1815 Asn Ile Phe Ile Gly Asp Lys Val Gly His Tyr Val His Val Lys 1820 1825 1830 Cys Glu Gln Ser Tyr Gln Leu Tyr Asp Ala Ser Asn Val Lys Lys 1835 1840 1845 Val Thr Asp Val Thr Gly Lys Leu Ser Asp Cys Leu Tyr Leu Lys 1850 1855 1860 Asn Leu Lys Gln Thr Phe Lys Ser Val Leu Thr Thr Tyr Tyr Leu 1865 1870 1875 Asp Asp Val Lys Lys Ile Glu Tyr Lys Pro Asp Leu Ser Gln Tyr 1880 1885 1890 Tyr Cys Asp Gly Gly Lys Tyr Tyr Thr Gln Arg Ile Ile Lys Ala 1895 1900 1905 Gln Phe Lys Thr Phe Glu Lys Val Asp Gly Val Tyr Thr Asn Phe 1910 1915 1920 Lys Leu Ile Gly His Thr Val Cys Asp Ser Leu Asn Ala Lys Leu 1925 1930 1935 Gly Phe Asp Ser Ser Lys Glu Phe Val Glu Tyr Lys Ile Thr Glu 1940 1945 1950 Trp Pro Thr Ala Thr Gly Asp Val Val Leu Ala Thr Asp Asp Leu 1955 1960 1965 Tyr Val Lys Arg Tyr Glu Arg Gly Cys Ile Thr Phe Gly Lys Pro 1970 1975 1980 Val Ile Trp Leu Ser His Glu Lys Ala Ser Leu Asn Ser Leu Thr 1985 1990 1995 Tyr Phe Asn Arg Pro Ser Leu Val Asp Asp Asn Lys Phe Asp Val 2000 2005 2010 Leu Lys Val Asp Asp Val Asp Asp Gly Gly Asp Ser Ser Glu Ser 2015 2020 2025 Gly Ala Lys Glu Thr Lys Glu Ile Asn Ile Ile Lys Leu Ser Gly 2030 2035 2040 Val Lys Lys Pro Phe Lys Val Glu Asp Ser Val Ile Val Asn Asp 2045 2050 2055 Asp Thr Ser Glu Thr Lys Tyr Val Lys Ser Leu Ser Ile Val Asp 2060 2065 2070 Val Tyr Asp Met Trp Leu Thr Gly Cys Lys Tyr Val Val Arg Thr 2075 2080 2085 Ala Asn Ala Leu Ser Arg Ala Val Asn Val Pro Thr Ile Arg Lys 2090 2095 2100 Phe Ile Lys Phe Gly Met Thr Leu Val Ser Ile Pro Ile Asp Leu 2105 2110 2115 Leu Asn Leu Arg Glu Ile Lys Pro Ala Val Asn Val Val Lys Ala 2120 2125 2130 Val Arg Asn Lys Ile Ser Val Cys Phe Asn Phe Ile Lys Trp Leu 2135 2140 2145 Phe Val Leu Leu Phe Gly Trp Ile Lys Ile Ser Ala Asp Asn Lys 2150 2155 2160 Val Ile Tyr Thr Thr Glu Ile Ala Ser Lys Leu Thr Cys Lys Leu 2165 2170 2175 Val Ala Leu Ala Phe Lys Asn Ala Phe Leu Thr Phe Lys Trp Ser 2180 2185 2190 Met Val Ala Arg Gly Ala Cys Ile Ile Ala Thr Ile Phe Leu Leu 2195 2200 2205 Trp Phe Asn Phe Ile Tyr Ala Asn Val Ile Phe Ser Asp Phe Tyr 2210 2215 2220 Leu Pro Lys Ile Gly Phe Leu Pro Thr Phe Val Gly Lys Ile Ala 2225 2230 2235 Gln Trp Ile Lys Asn Thr Phe Ser Leu Val Thr Ile Cys Asp Leu 2240 2245 2250 Tyr Ser Met Gln Asp Val Gly Phe Lys Asn Gln Tyr Cys Asn Gly 2255 2260 2265 Ser Ile Ala Cys Gln Phe Cys Leu Ala Gly Phe Asp Met Leu Asp 2270 2275 2280 Asn Tyr Lys Ala Ile Asp Val Val Gln Tyr Glu Ala Asp Arg Arg 2285 2290 2295 Ala Phe Val Asp Tyr Thr Gly Val Leu Lys Ile Val Ile Glu Leu 2300 2305 2310 Ile Val Ser Tyr Ala Leu Tyr Thr Ala Trp Phe Tyr Pro Leu Phe 2315 2320 2325 Ala Leu Ile Ser Ile Gln Ile Leu Thr Thr Trp Leu Pro Glu Leu 2330 2335 2340 Phe Met Leu Ser Thr Leu His Trp Ser Phe Arg Leu Leu Val Ala 2345 2350 2355 Leu Ala Asn Met Leu Pro Ala His Val Phe Met Arg Phe Tyr Ile 2360 2365 2370 Ile Ile Ala Ser Phe Ile Lys Leu Phe Ser Leu Phe Arg His Val 2375 2380 2385 Ala Tyr Gly Cys Ser Lys Ser Gly Cys Leu Phe Cys Tyr Lys Arg 2390 2395 2400 Asn Arg Ser Leu Arg Val Lys Cys Ser Thr Ile Val Gly Gly Met 2405 2410 2415 Ile Arg Tyr Tyr Asp Val Met Ala Asn Gly Gly Thr Gly Phe Cys 2420 2425 2430 Ser Lys His Gln Trp Asn Cys Ile Asp Cys Asp Ser Tyr Lys Pro 2435 2440 2445 Gly Asn Thr Phe Ile Thr Val Glu Ala Ala Leu Asp Leu Ser Lys 2450 2455 2460 Glu Leu Lys Arg Pro Ile Gln Pro Thr Asp Val Ala Tyr His Thr 2465 2470 2475 Val Thr Asp Val Lys Gln Val Gly Cys Ser Met Arg Leu Phe Tyr 2480 2485 2490 Asp Arg Asp Gly Gln Arg Thr Tyr Asp Asp Val Asn Ala Ser Leu 2495 2500 2505 Phe Val Asp Tyr Ser Asn Leu Leu His Ser Lys Val Lys Ser Val 2510 2515 2520 Pro Asn Met His Val Val Val Val Glu Asn Asp Ala Asp Lys Ala 2525 2530 2535 Asn Phe Leu Asn Ala Ala Val Phe Tyr Ala Gln Ser Leu Phe Arg 2540 2545 2550 Pro Ile Leu Met Val Asp Lys Asn Leu Ile Thr Thr Ala Asn Thr 2555 2560 2565 Gly Thr Ser Val Thr Glu Thr Met Phe Asp Val Tyr Val Asp Thr 2570 2575 2580 Phe Leu Ser Met Phe Asp Val Asp Lys Lys Ser Leu Asn Ala Leu 2585 2590 2595 Ile Ala Thr Ala His Ser Ser Ile Lys Gln Gly Thr Gln Ile Tyr 2600 2605 2610 Lys Val Leu Asp Thr Phe Leu Ser Cys Ala Arg Lys Ser Cys Ser 2615 2620 2625 Ile Asp Ser Asp Val Asp Thr Lys Cys Leu Ala Asp Ser Val Met 2630 2635 2640 Ser Ala Val Ser Ala Gly Leu Glu Leu Thr Asp Glu Ser Cys Asn 2645 2650 2655 Asn Leu Val Pro Thr Tyr Leu Lys Ser Asp Asn Ile Val Ala Ala 2660 2665 2670 Asp Leu Gly Val Leu Ile Gln Asn Ser Ala Lys His Val Gln Gly 2675 2680 2685 Asn Val Ala Lys Ile Ala Gly Val Ser Cys Ile Trp Ser Val Asp 2690 2695 2700 Ala Phe Asn Gln Phe Ser Ser Asp Phe Gln His Lys Leu Lys Lys 2705 2710 2715 Ala Cys Cys Lys Thr Gly Leu Lys Leu Lys Leu Thr Tyr Asn Lys 2720 2725 2730 Gln Met Ala Asn Val Ser Val Leu Thr Thr Pro Phe Ser Leu Lys 2735 2740 2745 Gly Gly Ala Val Phe Ser Tyr Phe Val Tyr Val Cys Phe Val Leu 2750 2755 2760 Ser Leu Val Cys Phe Ile Gly Leu Trp Cys Leu Met Pro Thr Tyr 2765 2770 2775 Thr Val His Lys Ser Asp Phe Gln Leu Pro Val Tyr Ala Ser Tyr 2780 2785 2790 Lys Val Leu Asp Asn Gly Val Ile Arg Asp Val Ser Val Glu Asp 2795 2800 2805 Val Cys Phe Ala Asn Lys Phe Glu Gln Phe Asp Gln Trp Tyr Glu 2810 2815 2820 Ser Thr Phe Gly Leu Ser Tyr Tyr Ser Asn Ser Met Ala Cys Pro 2825 2830 2835 Ile Val Val Ala Val Ile Asp Gln Asp Phe Gly Ser Thr Val Phe 2840 2845 2850 Asn Val Pro Thr Lys Val Leu Arg Tyr Gly Tyr His Val Leu His 2855 2860 2865 Phe Ile Thr His Ala Leu Ser Ala Asp Gly Val Gln Cys Tyr Thr 2870 2875 2880 Pro His Ser Gln Ile Ser Tyr Ser Asn Phe Tyr Ala Ser Gly Cys 2885 2890 2895 Val Leu Ser Ser Ala Cys Thr Met Phe Thr Met Ala Asp Gly Ser 2900 2905 2910 Pro Gln Pro Tyr Cys Tyr Thr Glu Gly Leu Met Gln Asn Ala Ser 2915 2920 2925 Leu Tyr Ser Ser Leu Val Pro His Val Arg Tyr Asn Leu Ala Asn 2930 2935 2940 Ala Lys Gly Phe Ile Arg Phe Pro Glu Val Leu Arg Glu Gly Leu 2945 2950 2955 Val Arg Ile Val Arg Thr Arg Ser Met Ser Tyr Cys Arg Val Gly 2960 2965 2970 Leu Cys Glu Glu Ala Asp Glu Gly Ile Cys Phe Asn Phe Asn Gly 2975 2980 2985 Ser Trp Val Leu Asn Asn Asp Tyr Tyr Arg Ser Leu Pro Gly Thr 2990 2995 3000 Phe Cys Gly Arg Asp Val Phe Asp Leu Ile Tyr Gln Leu Phe Lys 3005 3010 3015 Gly Leu Ala Gln Pro Val Asp Phe Leu Ala Leu Thr Ala Ser Ser 3020 3025 3030 Ile Ala Gly Ala Ile Leu Ala Val Ile Val Val Leu Val Phe Tyr 3035 3040 3045 Tyr Leu Ile Lys Leu Lys Arg Ala Phe Gly Asp Tyr Thr Ser Val 3050 3055 3060 Val Phe Val Asn Val Ile Val Trp Cys Val Asn Phe Met Met Leu 3065 3070 3075 Phe Val Phe Gln Val Tyr Pro Ile Leu Ser Cys Val Tyr Ala Ile 3080 3085 3090 Cys Tyr Phe Tyr Ala Thr Leu Tyr Phe Pro Ser Glu Ile Ser Val 3095 3100 3105 Ile Met His Leu Gln Trp Leu Val Met Tyr Gly Thr Ile Met Pro 3110 3115 3120 Leu Trp Phe Cys Leu Leu Tyr Ile Ala Val Val Val Ser Asn His 3125 3130 3135 Ala Phe Trp Val Phe Ser Tyr Cys Arg Lys Leu Gly Thr Ser Val 3140 3145 3150 Arg Ser Asp Gly Thr Phe Glu Glu Met Ala Leu Thr Thr Phe Met 3155 3160 3165 Ile Thr Lys Asp Ser Tyr Cys Lys Leu Lys Asn Ser Leu Ser Asp 3170 3175 3180 Val Ala Phe Asn Arg Tyr Leu Ser Leu Tyr Asn Lys Tyr Arg Tyr 3185 3190 3195 Tyr Ser Gly Lys Met Asp Thr Ala Ala Tyr Arg Glu Ala Ala Cys 3200 3205 3210 Ser Gln Leu Ala Lys Ala Met Asp Thr Phe Thr Asn Asn Asn Gly 3215 3220 3225 Ser Asp Val Leu Tyr Gln Pro Pro Thr Ala Ser Val Ser Thr Ser 3230 3235 3240 Phe Leu Gln Ser Gly Ile Val Lys Met Val Asn Pro Thr Ser Lys 3245 3250 3255 Val Glu Pro Cys Val Val Ser Val Thr Tyr Gly Asn Met Thr Leu 3260 3265 3270 Asn Gly Leu Trp Leu Asp Asp Lys Val Tyr Cys Pro Arg His Val 3275 3280 3285 Ile Cys Ser Ala Ser Asp Met Thr Asn Pro Asp Tyr Thr Asn Leu 3290 3295 3300 Leu Cys Arg Val Thr Ser Ser Asp Phe Thr Val Leu Phe Asp Arg 3305 3310 3315 Leu Ser Leu Thr Val Met Ser Tyr Gln Met Arg Gly Cys Met Leu 3320 3325 3330 Val Leu Thr Val Thr Leu Gln Asn Ser Arg Thr Pro Lys Tyr Thr 3335 3340 3345 Phe Gly Val Val Lys Pro Gly Glu Thr Phe Thr Val Leu Ala Ala 3350 3355 3360 Tyr Asn Gly Lys Pro Gln Gly Ala Phe His Val Thr Met Arg Ser 3365 3370 3375 Ser Tyr Thr Ile Lys Gly Ser Phe Leu Cys Gly Ser Cys Gly Ser 3380 3385 3390 Val Gly Tyr Val Ile Met Gly Asp Cys Val Lys Phe Val Tyr Met 3395 3400 3405 His Gln Leu Glu Leu Ser Thr Gly Cys His Thr Gly Thr Asp Phe 3410 3415 3420 Asn Gly Asp Phe Tyr Gly Pro Tyr Lys Asp Ala Gln Val Val Gln 3425 3430 3435 Leu Leu Ile Gln Asp Tyr Ile Gln Ser Val Asn Phe Val Ala Trp 3440 3445 3450 Leu Tyr Ala Ala Ile Leu Asn Asn Cys Asn Trp Phe Val Gln Ser 3455 3460 3465 Asp Lys Cys Ser Val Glu Asp Phe Asn Val Trp Ala Leu Ser Asn 3470 3475 3480 Gly Phe Ser Gln Val Lys Ser Asp Leu Val Ile Asp Ala Leu Ala 3485 3490 3495 Ser Met Thr Gly Val Ser Leu Glu Thr Leu Leu Ala Ala Ile Lys 3500 3505 3510 Arg Leu Lys Asn Gly Phe Gln Gly Arg Gln Ile Met Gly Ser Cys 3515 3520 3525 Ser Phe Glu Asp Glu Leu Thr Pro Ser Asp Val Tyr Gln Gln Leu 3530 3535 3540 Ala Gly Ile Lys Leu Gln Ser Lys Arg Thr Arg Leu Phe Lys Gly 3545 3550 3555 Thr Val Cys Trp Ile Met Ala Ser Thr Phe Leu Phe Ser Cys Ile 3560 3565 3570 Ile Thr Ala Phe Val Lys Trp Thr Met Phe Met Tyr Val Thr Thr 3575 3580 3585 Asn Met Phe Ser Ile Thr Phe Cys Ala Leu Cys Val Ile Ser Leu 3590 3595 3600 Ala Met Leu Leu Val Lys His Lys His Leu Tyr Leu Thr Met Tyr 3605 3610 3615 Ile Thr Pro Val Leu Phe Thr Leu Leu Tyr Asn Asn Tyr Leu Val 3620 3625 3630 Val Tyr Lys His Thr Phe Arg Gly Tyr Val Tyr Ala Trp Leu Ser 3635 3640 3645 Tyr Tyr Val Pro Ser Val Glu Tyr Thr Tyr Thr Asp Glu Val Ile 3650 3655 3660 Tyr Gly Met Leu Leu Leu Val Gly Met Val Phe Val Thr Leu Arg 3665 3670 3675 Ser Ile Asn His Asp Leu Phe Ser Phe Ile Met Phe Val Gly Arg 3680 3685 3690 Leu Ile Ser Val Phe Ser Leu Trp Tyr Lys Gly Ser Asn Leu Glu 3695 3700 3705 Glu Glu Ile Leu Leu Met Leu Ala Ser Leu Phe Gly Thr Tyr Thr 3710 3715 3720 Trp Thr Thr Val Leu Ser Met Ala Val Ala Lys Val Ile Ala Lys 3725 3730 3735 Trp Val Ala Val Asn Val Leu Tyr Phe Thr Asp Ile Pro Gln Ile 3740 3745 3750 Lys Ile Val Leu Leu Cys Tyr Leu Phe Ile Gly Tyr Ile Ile Ser 3755 3760 3765 Cys Tyr Trp Gly Leu Phe Ser Leu Met Asn Ser Leu Phe Arg Met 3770 3775 3780 Pro Leu Gly Val Tyr Asn Tyr Lys Ile Ser Val Gln Glu Leu Arg 3785 3790 3795 Tyr Met Asn Ala Asn Gly Leu Arg Pro Pro Lys Asn Ser Phe Glu 3800 3805 3810 Ala Leu Met Leu Asn Phe Lys Leu Leu Gly Ile Gly Gly Val Pro 3815 3820 3825 Ile Ile Glu Val Ser Gln Phe Gln Ser Lys Leu Thr Asp Val Lys 3830 3835 3840 Cys Ala Asn Val Val Leu Leu Asn Cys Leu Gln His Leu His Val 3845 3850 3855 Ala Ser Asn Ser Lys Leu Trp His Tyr Cys Ser Thr Leu His Asn 3860 3865 3870 Glu Ile Leu Ala Thr Ser Asp Leu Ser Val Ala Phe Glu Lys Leu 3875 3880 3885 Ala Gln Leu Leu Ile Val Leu Phe Ala Asn Pro Ala Ala Val Asp 3890 3895 3900 Ser Lys Cys Leu Thr Ser Ile Glu Glu Val Cys Asp Asp Tyr Ala 3905 3910 3915 Lys Asp Asn Thr Val Leu Gln Ala Leu Gln Ser Glu Phe Val Asn 3920 3925 3930 Met Ala Ser Phe Val Glu Tyr Glu Val Ala Lys Lys Asn Leu Asp 3935 3940 3945 Glu Ala Arg Phe Ser Gly Ser Ala Asn Gln Gln Gln Leu Lys Gln 3950 3955 3960 Leu Glu Lys Ala Cys Asn Ile Ala Lys Ser Ala Tyr Glu Arg Asp 3965 3970 3975 Arg Ala Val Ala Lys Lys Leu Glu Arg Met Ala Asp Leu Ala Leu 3980 3985 3990 Thr Asn Met Tyr Lys Glu Ala Arg Ile Asn Asp Lys Lys Ser Lys 3995 4000 4005 Val Val Ser Ala Leu Gln Thr Met Leu Phe Ser Met Val Arg Lys 4010 4015 4020 Leu Asp Asn Gln Ala Leu Asn Ser Ile Leu Asp Asn Ala Val Lys 4025 4030 4035 Gly Cys Val Pro Leu Asn Ala Ile Pro Ser Leu Ala Ala Asn Thr 4040 4045 4050 Leu Asn Ile Ile Val Pro Asp Lys Ser Val Tyr Asp Gln Val Val 4055 4060 4065 Asp Asn Val Tyr Val Thr Tyr Ala Gly Asn Val Trp Gln Ile Gln 4070 4075 4080 Thr Ile Gln Asp Ser Asp Gly Thr Asn Lys Gln Leu Asn Glu Ile 4085 4090 4095 Ser Asp Asp Cys Asn Trp Pro Leu Val Ile Ile Ala Asn Arg Tyr 4100 4105 4110 Asn Glu Val Ser Ala Thr Val Leu Gln Asn Asn Glu Leu Met Pro 4115 4120 4125 Ala Lys Leu Lys Ile Gln Val Val Asn Ser Gly Pro Asp Gln Thr 4130 4135 4140 Cys Asn Thr Pro Thr Gln Cys Tyr Tyr Asn Asn Ser Asn Asn Gly 4145 4150 4155 Lys Ile Val Tyr Ala Ile Leu Ser Asp Val Asp Gly Leu Lys Tyr 4160 4165 4170 Thr Lys Ile Leu Lys Asp Asp Gly Asn Phe Val Val Leu Glu Leu 4175 4180 4185 Asp Pro Pro Cys Lys Phe Thr Val Gln Asp Ala Lys Gly Leu Lys 4190 4195 4200 Ile Lys Tyr Leu Tyr Phe Val Lys Gly Cys Asn Thr Leu Ala Arg 4205 4210 4215 Gly Trp Val Val Gly Thr Ile Ser Ser Thr Val Arg Leu Gln Ala 4220 4225 4230 Gly Thr Ala Thr Glu Tyr Ala Ser Asn Ser Ser Ile Leu Ser Leu 4235 4240 4245 Cys Ala Phe Ser Val Asp Pro Lys Lys Thr Tyr Leu Asp Phe Ile 4250 4255 4260 Gln Gln Gly Gly Thr Pro Ile Ala Asn Cys Val Lys Met Leu Cys 4265 4270 4275 Asp His Ala Gly Thr Gly Met Ala Ile Thr Val Lys Pro Asp Ala 4280 4285 4290 Thr Thr Ser Gln Asp Ser Tyr Gly Gly Ala Ser Val Cys Ile Tyr 4295 4300 4305 Cys Arg Ala Arg Val Glu His Pro Asp Val Asp Gly Leu Cys Lys 4310 4315 4320 Leu Arg Gly Lys Phe Val Gln Val Pro Val Gly Ile Lys Asp Pro 4325 4330 4335 Val Ser Tyr Val Leu Thr His Asp Val Cys Arg Val Cys Gly Phe 4340 4345 4350 Trp Arg Asp Gly Ser Cys Ser Cys Val Ser Thr Asp Thr Thr Val 4355 4360 4365 Gln Ser Lys Asp Thr Asn Phe Phe Lys Arg Val Arg Gly Thr Ser 4370 4375 4380 Val Asp Ala Arg Leu Val Pro Cys Ala Ser Gly Leu Ser Thr Asp 4385 4390 4395 Val Gln Leu Arg Ala Phe Asp Ile Tyr Asn Ala Ser Val Ala Gly 4400 4405 4410 Ile Gly Leu His Leu Lys Val Asn Cys Cys Arg Phe Gln Arg Val 4415 4420 4425 Asp Glu Asn Gly Asp Lys Leu Asp Gln Phe Phe Val Val Lys Arg 4430 4435 4440 Thr Asp Leu Thr Ile Tyr Asn Arg Glu Met Lys Cys Tyr Glu Arg 4445 4450 4455 Val Lys Asp Cys Lys Phe Val Ala Glu His Asp Phe Phe Thr Phe 4460 4465 4470 Asp Val Glu Gly Ser Arg Val Pro His Ile Val Arg Lys Asp Leu 4475 4480 4485 Thr Lys Tyr Thr Met Leu Asp Leu Cys Tyr Ala Leu Arg His Phe 4490 4495 4500 Asp Arg Asn Asp Cys Met Leu Leu Cys Asp Ile Leu Ser Ile Tyr 4505 4510 4515 Ala Gly Cys Glu Gln Ser Tyr Phe Thr Lys Lys Asp Trp Tyr Asp 4520 4525 4530 Phe Val Glu Asn Pro Asp Ile Ile Asn Val Tyr Lys Lys Leu Gly 4535 4540 4545 Pro Ile Phe Asn Arg Ala Leu Val Ser Ala Thr Glu Phe Ala Asp 4550 4555 4560 Lys Leu Val Glu Val Gly Leu Val Gly Val Leu Thr Leu Asp Asn 4565 4570 4575 Gln Asp Leu Asn Gly Lys Trp Tyr Asp Phe Gly Asp Tyr Val Ile 4580 4585 4590 Ala Ala Pro Gly Cys Gly Val Ala Ile Ala Asp Ser Tyr Tyr Ser 4595 4600 4605 Tyr Ile Met Pro Met Leu Thr Met Cys His Ala Leu Asp Cys Glu 4610 4615 4620 Leu Tyr Val Asn Asn Ala Tyr Arg Leu Phe Asp Leu Val Gln Tyr 4625 4630 4635 Asp Phe Thr Asp Tyr Lys Leu Glu Leu Phe Asn Lys Tyr Phe Lys 4640 4645 4650 His Trp Ser Met Pro Tyr His Pro Asn Thr Val Asp Cys Gln Asp 4655 4660 4665 Asp Arg Cys Ile Ile His Cys Ala Asn Phe Asn Ile Leu Phe Ser 4670 4675 4680 Met Val Leu Pro Asn Thr Cys Phe Gly Pro Leu Val Arg Gln Ile 4685 4690 4695 Phe Val Asp Gly Val Pro Phe Val Val Ser Ile Gly Tyr His Tyr 4700 4705 4710 Lys Glu Leu Gly Ile Val Met Asn Met Asp Val Asp Thr His Arg 4715 4720 4725 Tyr Arg Leu Ser Leu Lys Asp Leu Leu Leu Tyr Ala Ala Asp Pro 4730 4735 4740 Ala Leu His Val Ala Ser Ala Ser Ala Leu Tyr Asp Leu Arg Thr 4745 4750 4755 Cys Cys Phe Ser Val Ala Ala Ile Thr Ser Gly Val Lys Phe Gln 4760 4765 4770 Thr Val Lys Pro Gly Asn Phe Asn Gln Asp Phe Tyr Asp Phe Val 4775 4780 4785 Leu Ser Lys Gly Leu Leu Lys Glu Gly Ser Ser Val Asp Leu Lys 4790 4795 4800 His Phe Phe Phe Thr Gln Asp Gly Asn Ala Ala Ile Thr Asp Tyr 4805 4810 4815 Asn Tyr Tyr Lys Tyr Asn Leu Pro Thr Met Val Asp Ile Lys Gln 4820 4825 4830 Leu Leu Phe Val Leu Glu Val Val Tyr Lys Tyr Phe Glu Ile Tyr 4835 4840 4845 Asp Gly Gly Cys Ile Pro Ala Ser Gln Val Ile Val Asn Asn Tyr 4850 4855 4860 Asp Lys Ser Ala Gly Tyr Pro Phe Asn Lys Phe Gly Lys Ala Arg 4865 4870 4875 Leu Tyr Tyr Glu Ala Leu Ser Phe Glu Glu Gln Asp Glu Ile Tyr 4880 4885 4890 Ala Tyr Thr Lys Arg Asn Val Leu Pro Thr Leu Thr Gln Met Asn 4895 4900 4905 Leu Lys Tyr Ala Ile Ser Ala Lys Asn Arg Ala Arg Thr Val Ala 4910 4915 4920 Gly Val Ser Ile Leu Ser Thr Met Thr Gly Arg Met Phe His Gln 4925 4930 4935 Lys Cys Leu Lys Ser Ile Ala Ala Thr Arg Gly Val Pro Val Val 4940 4945 4950 Ile Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asp Asp Met Leu Arg 4955 4960 4965 Arg Leu Ile Lys Asp Val Asp Asn Pro Val Leu Met Gly Trp Asp 4970 4975 4980 Tyr Pro Lys Cys Asp Arg Ala Met Pro Asn Leu Leu Arg Ile Val 4985 4990 4995 Ser Ser Leu Val Leu Ala Arg Lys His Glu Thr Cys Cys Ser Gln 5000 5005 5010 Ser Asp Arg Phe Tyr Arg Leu Ala Asn Glu Cys Ala Gln Val Leu 5015 5020 5025 Ser Glu Ile Val Met Cys Gly Gly Cys Tyr Tyr Val Lys Pro Gly 5030 5035 5040 Gly Thr Ser Ser Gly Asp Ala Thr Thr Ala Phe Ala Asn Ser Val 5045 5050 5055 Phe Asn Ile Cys Gln Ala Val Ser Ala Asn Val Cys Ala Leu Met 5060 5065 5070 Ser Cys Asn Gly Asn Lys Ile Glu Asp Leu Ser Ile Arg Ala Leu 5075 5080 5085 Gln Lys Arg Leu Tyr Ser His Val Tyr Arg Ser Asp Lys Val Asp 5090 5095 5100 Ser Thr Phe Val Thr Glu Tyr Tyr Glu Phe Leu Asn Lys His Phe 5105 5110 5115 Ser Met Met Ile Leu Ser Asp Asp Gly Val Val Cys Tyr Asn Ser 5120 5125 5130 Asp Tyr Ala Ser Lys Gly Tyr Ile Ala Asn Ile Ser Ala Phe Gln 5135 5140 5145 Gln Val Leu Tyr Tyr Gln Asn Asn Val Phe Met Ser Glu Ser Lys 5150 5155 5160 Cys Trp Val Glu His Asp Ile Asn Asn Gly Pro His Glu Phe Cys 5165 5170 5175 Ser Gln His Thr Met Leu Val Lys Met Asp Gly Asp Asp Val Tyr 5180 5185 5190 Leu Pro Tyr Pro Asn Pro Ser Arg Ile Leu Gly Ala Gly Cys Phe 5195 5200 5205 Val Asp Asp Leu Leu Lys Thr Asp Ser Val Leu Leu Ile Glu Arg 5210 5215 5220 Phe Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu Val Tyr His Glu 5225 5230 5235 Asn Glu Glu Tyr Gln Lys Val Phe Arg Val Tyr Leu Ala Tyr Ile 5240 5245 5250 Lys Lys Leu Tyr Asn Asp Leu Gly Asn Gln Ile Leu Asp Ser Tyr 5255 5260 5265 Ser Val Ile Leu Ser Thr Cys Asp Gly Gln Lys Phe Thr Asp Glu 5270 5275 5280 Ser Phe Tyr Lys Asn Met Tyr Leu Arg Ser Ala Val Met Gln Ser 5285 5290 5295 Val Gly Ala Cys Val Val Cys Ser Ser Gln Thr Ser Leu Arg Cys 5300 5305 5310 Gly Ser Cys Ile Arg Lys Pro Leu Leu Cys Cys Lys Cys Cys Tyr 5315 5320 5325 Asp His Val Met Ala Thr Asp His Lys Tyr Val Leu Ser Val Ser 5330 5335 5340 Pro Tyr Val Cys Asn Ala Pro Gly Cys Asp Val Asn Asp Val Thr 5345 5350 5355 Lys Leu Tyr Leu Gly Gly Met Ser Tyr Tyr Cys Glu Asp His Lys 5360 5365 5370 Pro Gln Tyr Ser Phe Lys Leu Val Met Asn Gly Leu Val Phe Gly 5375 5380 5385 Leu Tyr Lys Gln Ser Cys Thr Gly Ser Pro Tyr Ile Asp Asp Phe 5390 5395 5400 Asn Arg Ile Ala Ser Cys Lys Trp Thr Asp Val Asp Asp Tyr Ile 5405 5410 5415 Leu Ala Asn Glu Cys Thr Glu Arg Leu Lys Leu Phe Ala Ala Glu 5420 5425 5430 Thr Gln Lys Ala Thr Glu Glu Ala Phe Lys Gln Ser Tyr Ala Ser 5435 5440 5445 Ala Thr Ile Gln Glu Ile Val Ser Glu Arg Glu Leu Ile Leu Ser 5450 5455 5460 Trp Glu Ile Gly Lys Val Lys Pro Pro Leu Asn Lys Asn Tyr Val 5465 5470 5475 Phe Thr Gly Tyr His Phe Thr Lys Asn Gly Lys Thr Val Leu Gly 5480 5485 5490 Glu Tyr Val Phe Asp Lys Ser Glu Leu Thr Asn Gly Val Tyr Tyr 5495 5500 5505 Arg Ala Thr Thr Thr Tyr Lys Leu Ser Val Gly Asp Val Phe Val 5510 5515 5520 Leu Thr Ser His Ser Val Ala Asn Leu Ser Ala Pro Thr Leu Val 5525 5530 5535 Pro Gln Glu Asn Tyr Ser Ser Ile Arg Phe Ala Ser Val Tyr Ser 5540 5545 5550 Val Leu Glu Thr Phe Gln Asn Asn Val Val Asn Tyr Gln His Ile 5555 5560 5565 Gly Met Lys Arg Tyr Cys Thr Val Gln Gly Pro Pro Gly Thr Gly 5570 5575 5580 Lys Ser His Leu Ala Ile Gly Leu Ala Val Phe Tyr Cys Thr Ala 5585 5590 5595 Arg Val Val Tyr Thr Ala Ala Ser His Ala Ala Val Asp Ala Leu 5600 5605 5610 Cys Glu Lys Ala Tyr Lys Phe Leu Asn Ile Asn Asp Cys Thr Arg 5615 5620 5625 Ile Val Pro Ala Lys Val Arg Val Glu Cys Tyr Asp Lys Phe Lys 5630 5635 5640 Ile Asn Asp Thr Thr Arg Lys Tyr Val Phe Thr Thr Ile Asn Ala 5645 5650 5655 Leu Pro Glu Met Val Thr Asp Ile Val Val Val Asp Glu Val Ser 5660 5665 5670 Met Leu Thr Asn Tyr Glu Leu Ser Val Ile Asn Ala Arg Ile Arg 5675 5680 5685 Ala Lys His Tyr Val Tyr Ile Gly Asp Pro Ala Gln Leu Pro Ala 5690 5695 5700 Pro Arg Val Leu Leu Ser Lys Gly Thr Leu Glu Pro Lys Tyr Phe 5705 5710 5715 Asn Thr Val Thr Lys Leu Met Cys Cys Leu Gly Pro Asp Ile Phe 5720 5725 5730 Leu Gly Thr Cys Tyr Arg Cys Pro Lys Glu Ile Val Asp Thr Val 5735 5740 5745 Ser Ala Leu Val Tyr Glu Asn Lys Leu Lys Ala Lys Asn Glu Ser 5750 5755 5760 Ser Ser Leu Cys Phe Lys Val Tyr Tyr Lys Gly Val Thr Thr His 5765 5770 5775 Glu Ser Ser Ser Ala Val Asn Met Gln Gln Ile Tyr Leu Ile Asn 5780 5785 5790 Lys Phe Leu Lys Ala Asn Pro Leu Trp His Lys Ala Val Phe Ile 5795 5800 5805 Ser Pro Tyr Asn Ser Gln Asn Phe Ala Ala Lys Arg Val Leu Gly 5810 5815 5820 Leu Gln Thr Gln Thr Val Asp Ser Ala Gln Gly Ser Glu Tyr Asp 5825 5830 5835 Tyr Val Ile Tyr Ser Gln Thr Ala Glu Thr Ala His Ser Val Asn 5840 5845 5850 Val Asn Arg Phe Asn Val Ala Ile Thr Arg Ala Lys Lys Gly Ile 5855 5860 5865 Leu Cys Val Met Ser Asn Met Gln Leu Phe Glu Ala Leu Gln Phe 5870 5875 5880 Thr Thr Leu Thr Leu Asp Lys Val Pro Gln Ala Val Glu Thr Lys 5885 5890 5895 Val Gln Cys Ser Thr Asn Leu Phe Lys Asp Cys Ser Lys Ser Tyr 5900 5905 5910 Ser Gly Tyr His Pro Ala His Ala Pro Ser Phe Leu Ala Val Asp 5915 5920 5925 Asp Lys Tyr Lys Ala Thr Gly Asp Leu Ala Val Cys Leu Gly Ile 5930 5935 5940 Gly Asp Ser Ala Val Thr Tyr Ser Arg Leu Ile Ser Leu Met Gly 5945 5950 5955 Phe Lys Leu Asp Val Thr Leu Asp Gly Tyr Cys Lys Leu Phe Ile 5960 5965 5970 Thr Lys Glu Glu Ala Val Lys Arg Val Arg Ala Trp Val Gly Phe 5975 5980 5985 Asp Ala Glu Gly Ala His Ala Thr Arg Asp Ser Ile Gly Thr Asn 5990 5995 6000 Phe Pro Leu Gln Leu Gly Phe Ser Thr Gly Ile Asp Phe Val Val 6005 6010 6015 Glu Ala Thr Gly Leu Phe Ala Asp Arg Asp Gly Tyr Ser Phe Lys 6020 6025 6030 Lys Ala Val Ala Lys Ala Pro Pro Gly Glu Gln Phe Lys His Leu 6035 6040 6045 Ile Pro Leu Met Thr Arg Gly His Arg Trp Asp Val Val Arg Pro 6050 6055 6060 Arg Ile Val Gln Met Phe Ala Asp His Leu Ile Asp Leu Ser Asp 6065 6070 6075 Cys Val Val Leu Val Thr Trp Ala Ala Asn Phe Glu Leu Thr Cys 6080 6085 6090 Leu Arg Tyr Phe Ala Lys Val Gly Arg Glu Ile Ser Cys Asn Val 6095 6100 6105 Cys Thr Lys Arg Ala Thr Val Tyr Asn Ser Arg Thr Gly Tyr Tyr 6110 6115 6120 Gly Cys Trp Arg His Ser Val Thr Cys Asp Tyr Leu Tyr Asn Pro 6125 6130 6135 Leu Ile Val Asp Ile Gln Gln Trp Gly Tyr Ile Gly Ser Leu Ser 6140 6145 6150 Ser Asn His Asp Leu Tyr Cys Ser Val His Lys Gly Ala His Val 6155 6160 6165 Ala Ser Ser Asp Ala Ile Met Thr Arg Cys Leu Ala Val Tyr Asp 6170 6175 6180 Cys Phe Cys Asn Asn Ile Asn Trp Asn Val Glu Tyr Pro Ile Ile 6185 6190 6195 Ser Asn Glu Leu Ser Ile Asn Thr Ser Cys Arg Val Leu Gln Arg 6200 6205 6210 Val Ile Leu Lys Ala Ala Met Leu Cys Asn Arg Tyr Thr Leu Cys 6215 6220 6225 Tyr Asp Ile Gly Asn Pro Lys Ala Ile Ala Cys Val Lys Asp Phe 6230 6235 6240 Asp Phe Lys Phe Tyr Asp Ala Gln Pro Ile Val Lys Ser Val Lys 6245 6250 6255 Thr Leu Leu Tyr Ser Phe Glu Ala His Lys Asp Ser Phe Lys Asp 6260 6265 6270 Gly Leu Cys Met Phe Trp Asn Cys Asn Val Asp Lys Tyr Pro Pro 6275 6280 6285 Asn Ala Val Val Cys Arg Phe Asp Thr Arg Val Leu Asn Asn Leu 6290 6295 6300 Asn Leu Pro Gly Cys Asn Gly Gly Ser Leu Tyr Val Asn Lys His 6305 6310 6315 Ala Phe His Thr Lys Pro Phe Ala Arg Ala Ala Phe Glu His Leu 6320 6325 6330 Lys Pro Met Pro Phe Phe Tyr Tyr Ser Asp Thr Pro Cys Val Tyr 6335 6340 6345 Met Asp Gly Met Asp Ala Lys Gln Val Asp Tyr Val Pro Leu Lys 6350 6355 6360 Ser Ala Thr Cys Ile Thr Arg Cys Asn Leu Gly Gly Ala Val Cys 6365 6370 6375 Leu Lys His Ala Glu Glu Tyr Arg Glu Tyr Leu Glu Ser Tyr Asn 6380 6385 6390 Thr Ala Thr Thr Ala Gly Phe Thr Phe Trp Val Tyr Lys Thr Phe 6395 6400 6405 Asp Phe Tyr Asn Leu Trp Asn Thr Phe Thr Lys Leu Gln Ser Leu 6410 6415 6420 Glu Asn Val Val Tyr Asn Leu Val Lys Thr Gly His Tyr Thr Gly 6425 6430 6435 Gln Ala Gly Glu Met Pro Cys Ala Ile Ile Asn Asp Lys Val Val 6440 6445 6450 Ala Lys Ile Asp Lys Glu Asp Val Val Ile Phe Ile Asn Asn Thr 6455 6460 6465 Thr Tyr Pro Thr Asn Val Ala Val Glu Leu Phe Ala Lys Arg Ser 6470 6475 6480 Val Arg His His Pro Glu Leu Lys Leu Phe Arg Asn Leu Asn Ile 6485 6490 6495 Asp Val Cys Trp Lys His Val Ile Trp Asp Tyr Ala Arg Glu Ser 6500 6505 6510 Ile Phe Cys Ser Asn Thr Tyr Gly Val Cys Met Tyr Thr Asp Leu 6515 6520 6525 Lys Phe Ile Asp Lys Leu Asn Val Leu Phe Asp Gly Arg Asp Asn 6530 6535 6540 Gly Ala Leu Glu Ala Phe Lys Arg Ser Asn Asn Gly Val Tyr Ile 6545 6550 6555 Ser Thr Thr Lys Val Lys Ser Leu Ser Met Ile Arg Gly Pro Pro 6560 6565 6570 Arg Ala Glu Leu Asn Gly Val Val Val Asp Lys Val Gly Asp Thr 6575 6580 6585 Asp Cys Val Phe Tyr Phe Ala Val Arg Lys Glu Gly Gln Asp Val 6590 6595 6600 Ile Phe Ser Gln Phe Asp Ser Leu Gly Val Ser Ser Asn Gln Ser 6605 6610 6615 Pro Gln Gly Asn Leu Gly Ser Asn Gly Lys Pro Gly Asn Val Gly 6620 6625 6630 Gly Asn Asp Ala Leu Ser Ile Ser Thr Ile Phe Thr Gln Ser Arg 6635 6640 6645 Val Ile Ser Ser Phe Thr Cys Arg Thr Asp Met Glu Lys Asp Phe 6650 6655 6660 Ile Ala Leu Asp Gln Asp Val Phe Ile Gln Lys Tyr Gly Leu Glu 6665 6670 6675 Asp Tyr Ala Phe Glu His Ile Val Tyr Gly Asn Phe Asn Gln Lys 6680 6685 6690 Ile Ile Gly Gly Leu His Leu Leu Ile Gly Leu Tyr Arg Arg Gln 6695 6700 6705 Gln Thr Ser Asn Leu Val Val Gln Glu Phe Val Ser Tyr Asp Ser 6710 6715 6720 Ser Ile His Ser Tyr Phe Ile Thr Asp Glu Lys Ser Gly Gly Ser 6725 6730 6735 Lys Ser Val Cys Thr Val Ile Asp Ile Leu Leu Asp Asp Phe Val 6740 6745 6750 Ala Leu Val Lys Ser Leu Asn Leu Asn Cys Val Ser Lys Val Val 6755 6760 6765 Asn Val Asn Val Asp Phe Lys Asp Phe Gln Phe Met Leu Trp Cys 6770 6775 6780 Asn Asp Glu Lys Val Met Thr Phe Tyr Pro Arg Leu Gln Ala Ala 6785 6790 6795 Ser Asp Trp Lys Pro Gly Tyr Ser Met Pro Val Leu Tyr Lys Tyr 6800 6805 6810 Leu Asn Ser Pro Met Glu Arg Val Ser Leu Trp Asn Tyr Gly Lys 6815 6820 6825 Pro Val Thr Leu Pro Thr Gly Cys Met Met Asn Val Ala Lys Tyr 6830 6835 6840 Thr Gln Leu Cys Gln Tyr Leu Asn Thr Thr Thr Leu Ala Val Pro 6845 6850 6855 Val Asn Met Arg Val Leu His Leu Gly Ala Gly Ser Glu Lys Gly 6860 6865 6870 Val Ala Pro Gly Ser Ala Val Leu Arg Gln Trp Leu Pro Ala Gly 6875 6880 6885 Thr Ile Leu Val Asp Asn Asp Leu Tyr Pro Phe Val Ser Asp Ser 6890 6895 6900 Val Ala Thr Tyr Phe Gly Asp Cys Ile Thr Leu Pro Phe Asp Cys 6905 6910 6915 Gln Trp Asp Leu Ile Ile Ser Asp Met Tyr Asp Pro Ile Thr Lys 6920 6925 6930 Asn Ile Gly Glu Tyr Asn Val Ser Lys Asp Gly Phe Phe Thr Tyr 6935 6940 6945 Ile Cys His Met Ile Arg Asp Lys Leu Ala Leu Gly Gly Ser Val 6950 6955 6960 Ala Ile Lys Ile Thr Glu Phe Ser Trp Asn Ala Glu Leu Tyr Lys 6965 6970 6975 Leu Met Gly Tyr Phe Ala Phe Trp Thr Val Phe Cys Thr Asn Ala 6980 6985 6990 Asn Ala Ser Ser Ser Glu Gly Phe Leu Ile Gly Ile Asn Tyr Leu 6995 7000 7005 Cys Lys Pro Lys Val Glu Ile Asp Gly Asn Val Met His Ala Asn 7010 7015 7020 Tyr Leu Phe Trp Arg Asn Ser Thr Val Trp Asn Gly Gly Ala Tyr 7025 7030 7035 Ser Leu Phe Asp Met Ala Lys Phe Pro Leu Lys Leu Ala Gly Thr 7040 7045 7050 Ala Val Ile Asn Leu Arg Ala Asp Gln Ile Asn Asp Met Val Tyr 7055 7060 7065 Ser Leu Leu Glu Lys Gly Lys Leu Leu Ile Arg Asp Thr Asn Lys 7070 7075 7080 Glu Val Phe Val Gly Asp Ser Leu Val Asn Val Ile 7085 7090 7095 <210> 26 <211> 6781 <212> PRT <213> porcine epidemic diarhhea virus <220> <221> MISC_FEATURE <223> ORF 1AB <400> 26 Met Ala Ser Asn His Val Thr Leu Ala Phe Ala Asn Asp Ala Glu Ile 1 5 10 15 Ser Ala Phe Gly Phe Cys Thr Ala Ser Glu Ala Val Ser Tyr Tyr Ser 20 25 30 Glu Ala Ala Ala Ser Gly Phe Met Gln Cys Arg Phe Val Ser Leu Asp 35 40 45 Leu Ala Asp Thr Val Glu Gly Leu Leu Pro Glu Asp Tyr Val Met Val 50 55 60 Val Ile Gly Thr Thr Lys Leu Ser Ala Tyr Val Asp Thr Phe Gly Ser 65 70 75 80 Arg Pro Arg Asn Ile Cys Gly Trp Leu Leu Phe Ser Asn Cys Asn Tyr 85 90 95 Phe Leu Glu Glu Leu Glu Leu Thr Phe Gly Arg Arg Gly Gly Asn Ile 100 105 110 Val Pro Val Asp Gln Tyr Met Cys Gly Ala Asp Gly Lys Pro Val Leu 115 120 125 Gln Glu Ser Glu Trp Glu Tyr Thr Asp Phe Phe Ala Asp Ser Glu Asp 130 135 140 Gly Gln Leu Asn Ile Ala Gly Ile Thr Tyr Val Lys Ala Trp Ile Val 145 150 155 160 Glu Arg Ser Asp Val Ser Tyr Ala Ser Gln Asn Leu Thr Ser Ile Lys 165 170 175 Ser Ile Thr Tyr Cys Ser Thr Tyr Glu His Thr Phe Leu Asp Gly Thr 180 185 190 Ala Met Lys Val Ala Arg Thr Pro Lys Ile Lys Lys Asn Val Val Leu 195 200 205 Ser Glu Pro Leu Ala Thr Ile Tyr Arg Glu Ile Gly Ser Pro Phe Val 210 215 220 Asp Asn Gly Ser Asp Ala Arg Ser Ile Ile Arg Arg Pro Val Phe Leu 225 230 235 240 His Ala Phe Val Lys Cys Lys Cys Gly Ser Tyr His Trp Thr Val Gly 245 250 255 Asp Trp Thr Ser Tyr Val Ser Thr Cys Cys Gly Phe Lys Cys Lys Pro 260 265 270 Val Leu Val Ala Ser Cys Ser Ala Met Pro Gly Ser Val Val Val Thr 275 280 285 Arg Ala Gly Ala Gly Thr Gly Val Lys Tyr Tyr Asn Asn Met Phe Leu 290 295 300 Arg His Val Ala Asp Ile Asp Gly Leu Ala Phe Trp Arg Ile Leu Lys 305 310 315 320 Val Gln Ser Lys Asp Asp Leu Ala Cys Ser Gly Lys Phe Leu Glu His 325 330 335 His Glu Glu Gly Phe Thr Asp Pro Cys Tyr Phe Leu Asn Asp Ser Ser 340 345 350 Leu Ala Thr Lys Leu Lys Phe Asp Ile Leu Ser Gly Lys Phe Ser Asp 355 360 365 Glu Val Lys Gln Ala Ile Ile Ala Gly His Val Val Val Gly Ser Ala 370 375 380 Leu Val Asp Ile Val Asp Asp Ala Leu Gly Gln Pro Trp Phe Ile Arg 385 390 395 400 Lys Leu Gly Asp Leu Ala Ser Ala Pro Trp Glu Gln Leu Lys Ala Val 405 410 415 Val Arg Gly Leu Gly Leu Leu Ser Asp Glu Val Val Leu Phe Gly Lys 420 425 430 Arg Leu Ser Cys Ala Thr Leu Ser Ile Val Asn Gly Val Phe Glu Phe 435 440 445 Leu Ala Asp Val Pro Glu Lys Leu Ala Ala Ala Val Thr Val Phe Val 450 455 460 Asn Phe Leu Asn Glu Phe Phe Glu Ser Ala Cys Asp Cys Leu Lys Val 465 470 475 480 Gly Gly Lys Thr Phe Asn Lys Val Gly Ser Tyr Val Leu Phe Asp Asn 485 490 495 Ala Leu Val Lys Leu Val Lys Ala Lys Ala Arg Gly Pro Arg Gln Ala 500 505 510 Gly Ile Cys Glu Val Arg Tyr Thr Ser Leu Val Val Gly Ser Thr Thr 515 520 525 Lys Val Val Ser Lys Arg Val Glu Asn Ala Asn Val Asn Leu Val Val 530 535 540 Val Asp Glu Asp Val Thr Leu Asn Thr Thr Gly Arg Thr Val Val Val 545 550 555 560 Asp Gly Leu Ala Phe Phe Glu Ser Asp Gly Phe Tyr Arg His Leu Ala 565 570 575 Asp Ala Asp Val Val Ile Glu His Pro Val Tyr Lys Ser Ala Cys Glu 580 585 590 Leu Lys Pro Val Phe Glu Cys Asp Pro Ile Pro Asp Phe Pro Leu Pro 595 600 605 Val Ala Ala Ser Val Ala Glu Leu Cys Val Gln Thr Asp Leu Leu Leu 610 615 620 Lys Asn Tyr Asn Thr Pro Tyr Lys Thr Tyr Ser Cys Val Val Arg Gly 625 630 635 640 Asp Lys Cys Cys Ile Thr Cys Thr Leu Gln Phe Lys Ala Pro Ser Tyr 645 650 655 Val Glu Asp Ala Val Asn Phe Val Asp Leu Cys Thr Lys Asn Ile Gly 660 665 670 Thr Ala Gly Phe His Glu Phe Tyr Ile Thr Ala His Glu Gln Gln Asp 675 680 685 Leu Gln Gly Phe Leu Thr Thr Cys Cys Thr Met Ser Gly Phe Glu Cys 690 695 700 Phe Met Pro Thr Ile Pro Gln Cys Pro Ala Val Leu Glu Glu Ile Asp 705 710 715 720 Gly Gly Ser Ile Trp Arg Ser Phe Ile Thr Gly Leu Asn Thr Met Trp 725 730 735 Asp Phe Cys Lys Arg Leu Lys Val Ser Phe Gly Leu Asp Gly Ile Val 740 745 750 Val Thr Val Ala Arg Lys Phe Lys Arg Leu Gly Ala Leu Leu Ala Glu 755 760 765 Met Tyr Asn Thr Tyr Leu Ser Thr Val Val Glu Asn Leu Val Leu Ala 770 775 780 Gly Val Ser Phe Lys Tyr Tyr Ala Thr Ser Val Pro Lys Ile Val Leu 785 790 795 800 Gly Gly Cys Phe His Ser Val Lys Ser Val Phe Ala Ser Val Phe Gln 805 810 815 Ile Pro Val Gln Ala Gly Ile Glu Lys Phe Lys Val Phe Leu Asn Cys 820 825 830 Val His Pro Val Val Pro Arg Val Ile Glu Thr Ser Phe Val Glu Leu 835 840 845 Glu Glu Thr Thr Phe Lys Pro Pro Ala Leu Asn Gly Gly Ile Ala Ile 850 855 860 Val Asp Gly Phe Ala Phe Tyr Tyr Asp Gly Thr Leu Tyr Tyr Pro Thr 865 870 875 880 Asp Gly Asn Ser Val Val Pro Ile Cys Phe Lys Lys Lys Gly Gly Gly 885 890 895 Asp Val Lys Phe Ser Asp Glu Val Ser Val Lys Thr Ile Asp Pro Val 900 905 910 Tyr Lys Val Ser Leu Glu Phe Glu Phe Glu Ser Glu Thr Ile Met Ala 915 920 925 Val Leu Asn Lys Ala Val Gly Asn Arg Ile Lys Val Thr Gly Gly Trp 930 935 940 Asp Asp Val Val Glu Tyr Ile Asn Val Ala Ile Glu Val Leu Lys Asp 945 950 955 960 His Val Glu Val Pro Lys Tyr Tyr Ile Tyr Asp Glu Glu Gly Gly Thr 965 970 975 Asp Pro Asn Leu Pro Val Met Val Ser Gln Trp Pro Leu Asn Asp Asp 980 985 990 Thr Ile Ser Gln Asp Leu Leu Asp Val Glu Val Val Thr Asp Ala Pro 995 1000 1005 Ile Asp Ser Glu Gly Asp Glu Val Asp Ser Ser Ala Pro Glu Lys 1010 1015 1020 Val Ala Asp Val Ala Asn Ser Glu Pro Gly Asp Asp Gly Leu Pro 1025 1030 1035 Val Ala Pro Glu Thr Asn Val Glu Ser Glu Val Glu Glu Val Ala 1040 1045 1050 Ala Thr Leu Ser Phe Ile Lys Asp Thr Pro Ser Thr Val Thr Lys 1055 1060 1065 Asp Pro Phe Ala Phe Asp Phe Val Ser Tyr Gly Gly Leu Lys Val 1070 1075 1080 Leu Arg Gln Ser His Asn Asn Cys Trp Val Thr Ser Thr Leu Val 1085 1090 1095 Gln Leu Gln Leu Leu Gly Ile Val Asp Asp Pro Ala Met Glu Leu 1100 1105 1110 Phe Ser Ala Gly Arg Val Gly Pro Met Val Arg Lys Cys Tyr Glu 1115 1120 1125 Ser Gln Lys Ala Ile Leu Gly Ser Leu Gly Asp Val Ser Ala Cys 1130 1135 1140 Leu Glu Ser Leu Thr Lys Asp Leu His Thr Leu Lys Ile Thr Cys 1145 1150 1155 Ser Val Val Cys Gly Cys Gly Thr Gly Glu Arg Ile Tyr Glu Gly 1160 1165 1170 Cys Ala Phe Arg Met Thr Pro Thr Leu Glu Pro Phe Pro Tyr Gly 1175 1180 1185 Ala Cys Ala Gln Cys Ala Gln Val Leu Met His Thr Phe Lys Ser 1190 1195 1200 Ile Val Gly Thr Gly Ile Phe Cys Arg Asp Thr Thr Ala Leu Ser 1205 1210 1215 Leu Asp Ser Leu Val Val Lys Pro Leu Cys Ala Ala Ala Phe Ile 1220 1225 1230 Gly Lys Asp Ser Gly His Tyr Val Thr Asn Phe Tyr Asp Ala Ala 1235 1240 1245 Met Ala Ile Asp Gly Tyr Gly Arg His Gln Ile Lys Tyr Asp Thr 1250 1255 1260 Leu Asn Thr Ile Cys Val Lys Asp Val Asn Trp Thr Ala Pro Leu 1265 1270 1275 Val Pro Ala Val Asp Ser Val Val Glu Pro Val Val Lys Pro Phe 1280 1285 1290 Tyr Ser Tyr Lys Asn Val Asp Phe Tyr Gln Gly Asp Phe Ser Asp 1295 1300 1305 Leu Val Lys Leu Pro Cys Asp Phe Val Val Asn Ala Ala Asn Glu 1310 1315 1320 Lys Leu Ser His Gly Gly Gly Ile Ala Lys Ala Ile Asp Val Tyr 1325 1330 1335 Thr Lys Gly Met Leu Gln Lys Cys Ser Asn Asp Tyr Ile Lys Ala 1340 1345 1350 His Gly Pro Ile Lys Val Gly Arg Gly Val Met Leu Glu Ala Leu 1355 1360 1365 Gly Leu Lys Val Phe Asn Val Val Gly Pro Arg Lys Gly Lys His 1370 1375 1380 Ala Pro Glu Leu Leu Val Lys Ala Tyr Lys Ser Val Phe Ala Asn 1385 1390 1395 Ser Gly Val Ala Leu Thr Pro Leu Ile Ser Val Gly Ile Phe Ser 1400 1405 1410 Val Pro Leu Glu Glu Ser Leu Ser Ala Phe Leu Ala Cys Val Gly 1415 1420 1425 Asp Arg His Cys Lys Cys Phe Cys Tyr Gly Asp Lys Glu Arg Glu 1430 1435 1440 Ala Ile Ile Lys Tyr Met Asp Gly Leu Val Asp Ala Ile Phe Lys 1445 1450 1455 Glu Ala Leu Val Asp Thr Thr Pro Val Gln Glu Asp Val Gln Gln 1460 1465 1470 Val Ser Gln Lys Pro Val Leu Pro Asn Phe Glu Pro Phe Arg Ile 1475 1480 1485 Glu Gly Ala His Ala Phe Tyr Glu Cys Asn Pro Glu Gly Leu Met 1490 1495 1500 Ser Leu Gly Ala Asp Lys Leu Val Leu Phe Thr Asn Ser Asn Leu 1505 1510 1515 Asp Phe Cys Ser Val Gly Lys Cys Leu Asn Asp Val Thr Ser Gly 1520 1525 1530 Ala Leu Leu Glu Ala Ile Asn Val Phe Lys Lys Ser Asn Lys Thr 1535 1540 1545 Val Pro Ala Gly Asn Cys Val Thr Leu Asp Cys Ala Asn Met Ile 1550 1555 1560 Ser Ile Thr Met Val Val Leu Pro Phe Asp Gly Asp Ala Asn Tyr 1565 1570 1575 Asp Lys Asn Tyr Ala Arg Ala Val Val Lys Val Ser Lys Leu Lys 1580 1585 1590 Gly Lys Leu Val Leu Ala Val Asp Asp Ala Thr Leu Tyr Ser Lys 1595 1600 1605 Leu Ser His Leu Ser Val Leu Gly Phe Val Ser Thr Pro Asp Asp 1610 1615 1620 Val Glu Arg Phe Tyr Ala Asn Lys Ser Val Val Ile Lys Val Thr 1625 1630 1635 Glu Asp Thr Arg Ser Val Lys Ala Val Lys Val Glu Ser Thr Ala 1640 1645 1650 Thr Tyr Gly Gln Gln Ile Gly Pro Cys Leu Val Asn Asp Thr Val 1655 1660 1665 Val Thr Asp Asn Lys Pro Val Val Ala Asp Val Val Ala Lys Val 1670 1675 1680 Val Pro Asn Ala Asn Trp Asp Ser His Tyr Gly Phe Asp Lys Ala 1685 1690 1695 Gly Glu Phe His Met Leu Asp His Thr Gly Phe Thr Phe Pro Ser 1700 1705 1710 Glu Val Val Asn Gly Arg Arg Val Ile Lys Thr Thr Asp Asn Asn 1715 1720 1725 Cys Trp Val Asn Val Thr Cys Leu Gln Leu Gln Phe Ala Arg Phe 1730 1735 1740 Arg Phe Lys Ser Ala Gly Leu Gln Ala Met Trp Glu Ser Tyr Cys 1745 1750 1755 Thr Gly Asp Val Ala Met Phe Val His Trp Leu Tyr Trp Leu Thr 1760 1765 1770 Gly Val Asp Lys Gly Gln Pro Ser Asp Ser Glu Asn Ala Leu Asn 1775 1780 1785 Met Leu Ser Lys Tyr Ile Val Pro Ala Gly Ser Val Thr Ile Glu 1790 1795 1800 Arg Val Thr His Asp Gly Cys Cys Cys Ser Lys Arg Val Val Thr 1805 1810 1815 Ala Pro Val Val Asn Ala Ser Val Leu Lys Leu Gly Val Glu Asp 1820 1825 1830 Gly Leu Cys Pro His Gly Leu Asn Tyr Ile Gly Lys Val Val Val 1835 1840 1845 Val Lys Gly Thr Thr Ile Val Val Asn Val Gly Lys Pro Val Val 1850 1855 1860 Ala Pro Ser His Leu Phe Leu Lys Gly Val Ser Tyr Thr Thr Phe 1865 1870 1875 Leu Asp Asn Gly Asn Gly Val Val Gly His Tyr Thr Val Phe Asp 1880 1885 1890 His Gly Thr Gly Met Val His Asp Gly Asp Ala Phe Val Pro Gly 1895 1900 1905 Asp Leu Asn Val Ser Pro Val Thr Asn Val Val Val Ser Glu Gln 1910 1915 1920 Thr Ala Val Val Ile Lys Asp Pro Val Lys Lys Ala Glu Leu Asp 1925 1930 1935 Ala Thr Lys Leu Leu Asp Thr Met Asn Tyr Ala Ser Glu Arg Phe 1940 1945 1950 Phe Ser Phe Gly Asp Phe Met Ser Arg Asn Leu Ile Thr Val Phe 1955 1960 1965 Leu Tyr Ile Leu Ser Ile Leu Gly Leu Cys Phe Arg Ala Phe Arg 1970 1975 1980 Lys Arg Asp Val Lys Val Leu Ala Gly Val Pro Gln Arg Thr Gly 1985 1990 1995 Ile Ile Leu Arg Lys Ser Met Arg Tyr Asn Ala Lys Ala Leu Gly 2000 2005 2010 Val Phe Phe Lys Leu Lys Leu Tyr Trp Phe Lys Val Leu Gly Lys 2015 2020 2025 Phe Ser Leu Gly Ile Tyr Ala Leu Tyr Ala Leu Leu Phe Met Thr 2030 2035 2040 Ile Arg Phe Thr Pro Ile Gly Ser Pro Val Cys Asp Asp Val Val 2045 2050 2055 Ala Gly Tyr Ala Asn Ser Ser Phe Asp Lys Asn Glu Tyr Cys Asn 2060 2065 2070 Ser Val Ile Cys Lys Val Cys Leu Tyr Gly Tyr Gln Glu Leu Ser 2075 2080 2085 Asp Phe Ser His Thr Gln Val Val Trp Gln His Leu Arg Asp Pro 2090 2095 2100 Leu Ile Gly Asn Val Met Pro Phe Phe Tyr Leu Ala Phe Leu Ala 2105 2110 2115 Ile Phe Gly Gly Val Tyr Val Lys Ala Ile Thr Leu Tyr Phe Ile 2120 2125 2130 Phe Gln Tyr Leu Asn Ser Leu Gly Val Phe Leu Gly Leu Gln Gln 2135 2140 2145 Ser Ile Trp Phe Leu Gln Leu Val Pro Phe Asp Val Phe Gly Asp 2150 2155 2160 Glu Ile Val Val Phe Phe Ile Val Thr Arg Val Leu Met Phe Ile 2165 2170 2175 Lys His Val Cys Leu Gly Cys Asp Lys Ala Ser Cys Val Ala Cys 2180 2185 2190 Ser Lys Ser Ala Arg Leu Lys Arg Val Pro Val Gln Thr Ile Phe 2195 2200 2205 Gln Gly Thr Ser Lys Ser Phe Tyr Val His Ala Asn Gly Gly Ser 2210 2215 2220 Lys Phe Cys Lys Lys His Asn Phe Phe Cys Leu Asn Cys Asp Ser 2225 2230 2235 Tyr Gly Pro Gly Cys Thr Phe Ile Asn Asp Val Ile Ala Thr Glu 2240 2245 2250 Val Gly Asn Val Val Lys Leu Asn Val Gln Pro Thr Gly Pro Ala 2255 2260 2265 Thr Ile Leu Ile Asp Lys Val Glu Phe Ser Asn Gly Phe Tyr Tyr 2270 2275 2280 Leu Tyr Ser Gly Asp Thr Phe Trp Lys Tyr Asn Phe Asp Ile Thr 2285 2290 2295 Asp Ser Lys Tyr Thr Cys Lys Glu Ala Leu Lys Asn Cys Ser Ile 2300 2305 2310 Ile Thr Asp Phe Ile Val Phe Asn Asn Asn Gly Ser Asn Val Asn 2315 2320 2325 Gln Val Lys Asn Ala Cys Val Tyr Phe Ser Gln Met Leu Cys Lys 2330 2335 2340 Pro Val Lys Leu Val Asp Ser Ala Leu Leu Ala Ser Leu Ser Val 2345 2350 2355 Asp Phe Gly Ala Ser Leu His Ser Ala Phe Val Ser Val Leu Ser 2360 2365 2370 Asn Ser Phe Gly Lys Asp Leu Ser Ser Cys Asn Asp Met Gln Asp 2375 2380 2385 Cys Lys Ser Thr Leu Gly Phe Asp Asp Val Pro Leu Asp Thr Phe 2390 2395 2400 Asn Ala Ala Val Ala Glu Ala His Arg Tyr Asp Val Leu Leu Thr 2405 2410 2415 Asp Met Ser Phe Asn Asn Phe Thr Thr Ser Tyr Ala Lys Pro Glu 2420 2425 2430 Glu Lys Phe Pro Val His Asp Ile Ala Thr Cys Met Arg Val Gly 2435 2440 2445 Ala Lys Ile Val Asn His Asn Val Leu Val Lys Asp Ser Ile Pro 2450 2455 2460 Val Val Trp Leu Val Arg Asp Phe Ile Ala Leu Ser Glu Glu Thr 2465 2470 2475 Arg Lys Tyr Ile Ile Arg Thr Thr Lys Val Lys Gly Ile Thr Phe 2480 2485 2490 Met Leu Thr Phe Asn Asp Cys Arg Met His Thr Thr Ile Pro Thr 2495 2500 2505 Val Cys Ile Ala Asn Lys Lys Gly Ala Gly Leu Pro Ser Phe Ser 2510 2515 2520 Lys Val Lys Lys Phe Phe Trp Phe Leu Cys Leu Phe Ile Val Ala 2525 2530 2535 Ala Phe Phe Ala Leu Ser Phe Leu Asp Phe Ser Thr Gln Val Ser 2540 2545 2550 Ser Asp Ser Asp Tyr Asp Phe Lys Tyr Ile Glu Ser Gly Gln Leu 2555 2560 2565 Lys Thr Phe Asp Asn Pro Leu Ser Cys Val His Asn Val Phe Ile 2570 2575 2580 Asn Phe Asp Gln Trp His Asp Ala Lys Phe Gly Phe Thr Pro Val 2585 2590 2595 Asn Asn Pro Ser Cys Pro Ile Val Val Gly Val Ser Asp Glu Ala 2600 2605 2610 Arg Thr Val Pro Gly Ile Pro Ala Gly Val Tyr Leu Ala Gly Lys 2615 2620 2625 Thr Leu Val Phe Ala Ile Asn Thr Ile Phe Gly Thr Ser Gly Leu 2630 2635 2640 Cys Phe Asp Ala Ser Gly Val Ala Asp Lys Gly Ala Cys Ile Phe 2645 2650 2655 Asn Ser Ala Cys Thr Thr Leu Ser Gly Leu Gly Gly Thr Ala Val 2660 2665 2670 Tyr Cys Tyr Lys Asn Gly Leu Val Glu Gly Ala Lys Leu Tyr Ser 2675 2680 2685 Glu Leu Ala Pro His Ser Tyr Tyr Lys Met Val Asp Gly Asn Ala 2690 2695 2700 Val Ser Leu Pro Glu Ile Ile Ser Arg Gly Phe Gly Ile Arg Thr 2705 2710 2715 Ile Arg Thr Lys Ala Met Thr Tyr Cys Arg Val Gly Gln Cys Val 2720 2725 2730 Gln Ser Ala Glu Gly Val Cys Phe Gly Ala Asp Arg Phe Phe Val 2735 2740 2745 Tyr Asn Ala Glu Ser Gly Ser Asp Phe Val Cys Gly Thr Gly Leu 2750 2755 2760 Phe Thr Leu Leu Met Asn Val Ile Ser Val Phe Ser Lys Thr Val 2765 2770 2775 Pro Val Thr Val Leu Ser Gly Gln Ile Leu Phe Asn Cys Ile Ile 2780 2785 2790 Ala Phe Val Ala Val Ala Val Cys Phe Leu Phe Thr Lys Phe Lys 2795 2800 2805 Arg Met Phe Gly Asp Met Ser Val Gly Val Phe Thr Val Gly Ala 2810 2815 2820 Cys Thr Leu Leu Asn Asn Val Ser Tyr Ile Val Thr Gln Asn Thr 2825 2830 2835 Leu Gly Met Leu Gly Tyr Ala Thr Leu Tyr Phe Leu Cys Thr Lys 2840 2845 2850 Gly Val Arg Tyr Met Trp Ile Trp His Leu Gly Phe Leu Ile Ser 2855 2860 2865 Tyr Ile Leu Ile Ala Pro Trp Trp Val Leu Met Val Tyr Ala Phe 2870 2875 2880 Ser Ala Ile Phe Glu Phe Met Pro Asn Leu Phe Lys Leu Lys Val 2885 2890 2895 Ser Thr Gln Leu Phe Glu Gly Asp Lys Phe Val Gly Ser Phe Glu 2900 2905 2910 Asn Ala Ala Ala Gly Thr Phe Val Leu Asp Met His Ala Tyr Glu 2915 2920 2925 Arg Leu Ala Asn Ser Ile Ser Thr Glu Lys Leu Arg Gln Tyr Ala 2930 2935 2940 Ser Thr Tyr Asn Lys Tyr Lys Tyr Tyr Ser Gly Ser Ala Ser Glu 2945 2950 2955 Ala Asp Tyr Arg Leu Ala Cys Phe Ala His Leu Ala Lys Ala Met 2960 2965 2970 Met Asp Tyr Ala Ser Asn His Asn Asp Thr Leu Tyr Thr Pro Pro 2975 2980 2985 Thr Val Ser Tyr Asn Ser Thr Leu Gln Ala Gly Leu Arg Lys Met 2990 2995 3000 Ala Gln Pro Ser Gly Val Val Glu Lys Cys Ile Val Arg Val Cys 3005 3010 3015 Tyr Gly Asn Met Ala Leu Asn Gly Leu Trp Leu Gly Asp Ile Val 3020 3025 3030 Met Cys Pro Arg His Val Ile Ala Ser Ser Thr Thr Ser Thr Ile 3035 3040 3045 Asp Tyr Asp Tyr Ala Leu Ser Val Leu Arg Leu His Asn Phe Ser 3050 3055 3060 Ile Ser Ser Gly Asn Val Phe Leu Gly Val Val Ser Ala Thr Met 3065 3070 3075 Arg Gly Ala Leu Leu Gln Ile Lys Val Asn Gln Asn Asn Val His 3080 3085 3090 Thr Pro Lys Tyr Thr Tyr Arg Thr Val Arg Pro Gly Glu Ser Phe 3095 3100 3105 Asn Ile Leu Ala Cys Tyr Asp Gly Ala Ala Ala Gly Val Tyr Gly 3110 3115 3120 Val Asn Met Arg Ser Asn Tyr Thr Ile Arg Gly Ser Phe Ile Asn 3125 3130 3135 Gly Ala Cys Gly Ser Pro Gly Tyr Asn Ile Asn Asn Gly Thr Val 3140 3145 3150 Glu Phe Cys Tyr Leu His Gln Leu Glu Leu Gly Ser Gly Cys His 3155 3160 3165 Val Gly Ser Asp Leu Asp Gly Val Met Tyr Gly Gly Tyr Glu Asp 3170 3175 3180 Gln Pro Thr Leu Gln Val Glu Gly Ala Ser Ser Leu Phe Thr Glu 3185 3190 3195 Asn Val Leu Ala Phe Leu Tyr Ala Ala Leu Ile Asn Gly Ser Thr 3200 3205 3210 Trp Trp Leu Ser Ser Ser Arg Ile Ala Val Asp Arg Phe Asn Glu 3215 3220 3225 Trp Ala Val His Asn Gly Met Thr Thr Val Gly Asn Thr Asp Cys 3230 3235 3240 Phe Ser Ile Leu Ala Ala Lys Thr Gly Val Asp Val Gln Arg Leu 3245 3250 3255 Leu Ala Ser Ile Gln Ser Leu His Lys Asn Phe Gly Gly Lys Gln 3260 3265 3270 Ile Leu Gly His Thr Ser Leu Thr Asp Glu Phe Thr Thr Gly Glu 3275 3280 3285 Val Val Arg Gln Met Tyr Gly Val Asn Leu Gln Gly Gly Tyr Val 3290 3295 3300 Ser Arg Ala Cys Arg Asn Val Leu Leu Val Gly Ser Phe Leu Thr 3305 3310 3315 Phe Phe Trp Ser Glu Leu Val Ser Tyr Thr Lys Phe Phe Trp Val 3320 3325 3330 Asn Pro Gly Tyr Val Thr Pro Met Phe Ala Cys Leu Ser Leu Leu 3335 3340 3345 Ser Ser Leu Leu Met Phe Thr Leu Lys His Lys Thr Leu Phe Phe 3350 3355 3360 Gln Val Phe Leu Ile Pro Ala Leu Ile Val Thr Ser Cys Ile Asn 3365 3370 3375 Leu Ala Phe Asp Val Glu Val Tyr Asn Tyr Leu Ala Glu His Phe 3380 3385 3390 Asp Tyr His Val Ser Leu Met Gly Phe Asn Ala Gln Gly Leu Val 3395 3400 3405 Asn Ile Phe Val Cys Phe Val Val Thr Ile Leu His Gly Thr Tyr 3410 3415 3420 Thr Trp Arg Phe Phe Asn Thr Pro Ala Ser Ser Val Thr Tyr Val 3425 3430 3435 Val Ala Leu Leu Thr Ala Ala Tyr Asn Tyr Phe Tyr Ala Ser Asp 3440 3445 3450 Ile Leu Ser Cys Ala Met Thr Leu Phe Ala Ser Val Thr Gly Asn 3455 3460 3465 Trp Phe Val Gly Ala Val Cys Tyr Lys Val Ala Val Tyr Met Ala 3470 3475 3480 Leu Arg Phe Pro Thr Phe Val Ala Ile Phe Gly Asp Ile Lys Ser 3485 3490 3495 Val Met Phe Cys Tyr Leu Val Leu Gly Tyr Phe Thr Cys Cys Phe 3500 3505 3510 Tyr Gly Ile Leu Tyr Trp Phe Asn Arg Phe Phe Lys Val Ser Val 3515 3520 3525 Gly Val Tyr Asp Tyr Thr Val Ser Ala Ala Glu Phe Lys Tyr Met 3530 3535 3540 Val Ala Asn Gly Leu Arg Ala Pro Thr Gly Thr Leu Asp Ser Leu 3545 3550 3555 Leu Leu Ser Ala Lys Leu Ile Gly Ile Gly Gly Glu Arg Asn Ile 3560 3565 3570 Lys Ile Ser Ser Val Gln Ser Lys Leu Thr Asp Ile Lys Cys Ser 3575 3580 3585 Asn Val Val Leu Leu Gly Cys Leu Ser Ser Met Asn Val Ser Ala 3590 3595 3600 Asn Ser Thr Glu Trp Ala Tyr Cys Val Asp Leu His Asn Lys Ile 3605 3610 3615 Asn Leu Cys Asn Asp Pro Glu Lys Ala Gln Glu Met Leu Leu Ala 3620 3625 3630 Leu Leu Ala Phe Phe Leu Ser Lys Asn Ser Ala Phe Gly Leu Asp 3635 3640 3645 Asp Leu Leu Glu Ser Tyr Phe Asn Asp Asn Ser Met Leu Gln Ser 3650 3655 3660 Val Ala Ser Thr Tyr Val Gly Leu Pro Ser Tyr Val Ile Tyr Glu 3665 3670 3675 Asn Ala Arg Gln Gln Tyr Glu Asp Ala Val Asn Asn Gly Ser Pro 3680 3685 3690 Pro Gln Leu Val Lys Gln Leu Arg His Ala Met Asn Val Ala Lys 3695 3700 3705 Ser Glu Phe Asp Arg Glu Ala Ser Thr Gln Arg Lys Leu Asp Arg 3710 3715 3720 Met Ala Glu Gln Ala Ala Ala Gln Met Tyr Lys Glu Ala Arg Ala 3725 3730 3735 Val Asn Arg Lys Ser Lys Val Val Ser Ala Met His Ser Leu Leu 3740 3745 3750 Phe Gly Met Leu Arg Arg Leu Asp Met Ser Ser Val Asp Thr Ile 3755 3760 3765 Leu Asn Leu Ala Lys Asp Gly Val Val Pro Leu Ser Val Ile Pro 3770 3775 3780 Ala Val Ser Ala Thr Lys Leu Asn Ile Val Thr Ser Asp Ile Asp 3785 3790 3795 Ser Tyr Asn Arg Ile Gln Arg Glu Gly Cys Val His Tyr Ala Gly 3800 3805 3810 Thr Ile Trp Asn Ile Ile Asp Ile Lys Asp Asn Asp Gly Lys Val 3815 3820 3825 Val His Val Lys Glu Val Thr Ala Gln Asn Ala Glu Ser Leu Ser 3830 3835 3840 Trp Pro Leu Val Leu Gly Cys Glu Arg Ile Val Lys Leu Gln Asn 3845 3850 3855 Asn Glu Ile Ile Pro Gly Lys Leu Lys Gln Arg Ser Ile Lys Ala 3860 3865 3870 Glu Gly Asp Gly Ile Val Gly Glu Gly Lys Ala Leu Tyr Asn Asn 3875 3880 3885 Glu Gly Gly Arg Thr Phe Met Tyr Ala Phe Ile Ser Asp Lys Pro 3890 3895 3900 Asp Leu Arg Val Val Lys Trp Glu Phe Asp Gly Gly Cys Asn Thr 3905 3910 3915 Ile Glu Leu Glu Pro Pro Arg Lys Phe Leu Val Asp Ser Pro Asn 3920 3925 3930 Gly Ala Gln Ile Lys Tyr Leu Tyr Phe Val Arg Asn Leu Asn Thr 3935 3940 3945 Leu Arg Arg Gly Ala Val Leu Gly Tyr Ile Gly Ala Thr Val Arg 3950 3955 3960 Leu Gln Ala Gly Lys Gln Thr Glu Gln Ala Ile Asn Ser Ser Leu 3965 3970 3975 Leu Thr Leu Cys Ala Phe Ala Val Asp Pro Ala Lys Thr Tyr Ile 3980 3985 3990 Asp Ala Val Lys Ser Gly His Lys Pro Val Gly Asn Cys Val Lys 3995 4000 4005 Met Leu Ala Asn Gly Ser Gly Asn Gly Gln Ala Val Thr Asn Gly 4010 4015 4020 Val Glu Ala Ser Thr Asn Gln Asp Ser Tyr Gly Gly Ala Ser Val 4025 4030 4035 Cys Leu Tyr Cys Arg Ala His Val Glu His Pro Ser Met Asp Gly 4040 4045 4050 Phe Cys Arg Leu Lys Gly Lys Tyr Val Gln Val Pro Leu Gly Thr 4055 4060 4065 Val Asp Pro Ile Arg Phe Val Leu Glu Asn Asp Val Cys Lys Val 4070 4075 4080 Cys Gly Cys Trp Leu Ser Asn Gly Cys Thr Cys Asp Arg Ser Ile 4085 4090 4095 Met Gln Ser Thr Asp Tyr Gly Leu Phe Lys Arg Val Arg Gly Ser 4100 4105 4110 Ser Ala Ala Arg Leu Glu Pro Cys Asn Gly Thr Asp Thr Gln His 4115 4120 4125 Val Tyr Arg Ala Phe Asp Ile Tyr Asn Lys Asp Val Ala Cys Leu 4130 4135 4140 Gly Lys Phe Leu Lys Val Asn Cys Val Arg Leu Lys Asn Leu Asp 4145 4150 4155 Lys His Asp Ala Phe Tyr Val Val Lys Arg Cys Thr Lys Ser Ala 4160 4165 4170 Met Glu His Glu Gln Ser Ile Tyr Ser Arg Leu Glu Lys Cys Gly 4175 4180 4185 Ala Ile Ala Glu His Asp Phe Phe Thr Trp Lys Asp Gly Arg Ala 4190 4195 4200 Ile Tyr Gly Asn Val Cys Arg Lys Asp Leu Thr Glu Tyr Thr Met 4205 4210 4215 Met Asp Leu Cys Tyr Ala Leu Arg Asn Phe Asp Glu Asn Asn Cys 4220 4225 4230 Asp Val Leu Lys Ser Ile Leu Ile Lys Val Gly Ala Cys Glu Glu 4235 4240 4245 Ser Tyr Phe Asn Asn Lys Val Trp Phe Asp Pro Val Glu Asn Glu 4250 4255 4260 Asp Ile His Arg Val Tyr Ala Leu Leu Gly Thr Ile Val Ala Arg 4265 4270 4275 Ala Met Leu Lys Cys Val Lys Phe Cys Asp Ala Met Val Glu Gln 4280 4285 4290 Gly Ile Val Gly Val Val Thr Leu Asp Asn Gln Asp Leu Asn Gly 4295 4300 4305 Asp Phe Tyr Asp Phe Gly Asp Phe Thr Cys Ser Ile Lys Gly Met 4310 4315 4320 Gly Val Pro Ile Cys Thr Ser Tyr Tyr Ser Tyr Met Met Pro Val 4325 4330 4335 Met Gly Met Thr Asn Cys Leu Ala Ser Glu Cys Phe Val Lys Ser 4340 4345 4350 Asp Ile Phe Gly Glu Asp Phe Lys Ser Tyr Asp Leu Leu Glu Tyr 4355 4360 4365 Asp Phe Thr Glu His Lys Thr Ala Leu Phe Asn Lys Tyr Phe Lys 4370 4375 4380 Tyr Trp Gly Leu Gln Tyr His Pro Asn Cys Val Asp Cys Ser Asp 4385 4390 4395 Glu Gln Cys Ile Val His Cys Ala Asn Phe Asn Thr Leu Phe Ser 4400 4405 4410 Thr Thr Ile Pro Ile Thr Ala Phe Gly Pro Leu Cys Arg Lys Cys 4415 4420 4425 Trp Ile Asp Gly Val Pro Leu Val Thr Thr Ala Gly Tyr His Phe 4430 4435 4440 Lys Gln Leu Gly Ile Val Trp Asn Asn Asp Leu Asn Leu His Ser 4445 4450 4455 Ser Arg Leu Ser Ile Asn Glu Leu Leu Gln Phe Cys Ser Asp Pro 4460 4465 4470 Ala Leu Leu Ile Ala Ser Ser Pro Ala Leu Val Asp Gln Arg Thr 4475 4480 4485 Val Cys Phe Ser Val Ala Ala Leu Gly Thr Gly Met Thr Asn Gln 4490 4495 4500 Thr Val Lys Pro Gly His Phe Asn Lys Glu Phe Tyr Asp Phe Leu 4505 4510 4515 Leu Glu Gln Gly Phe Phe Ser Glu Gly Ser Glu Leu Thr Leu Lys 4520 4525 4530 His Phe Phe Phe Ala Gln Lys Val Asp Ala Ala Val Lys Asp Phe 4535 4540 4545 Asp Tyr Tyr Arg Tyr Asn Arg Pro Thr Val Leu Asp Ile Cys Gln 4550 4555 4560 Ala Arg Val Val Tyr Gln Ile Val Gln Arg Tyr Phe Asp Ile Tyr 4565 4570 4575 Glu Gly Gly Cys Ile Thr Ala Lys Glu Val Val Val Thr Asn Leu 4580 4585 4590 Asn Lys Ser Ala Gly Tyr Pro Leu Asn Lys Phe Gly Lys Ala Gly 4595 4600 4605 Leu Tyr Tyr Glu Ser Leu Ser Tyr Glu Glu Gln Asp Glu Leu Tyr 4610 4615 4620 Ala Tyr Thr Lys Arg Asn Ile Leu Pro Thr Met Thr Gln Leu Asn 4625 4630 4635 Leu Lys Tyr Ala Ile Ser Gly Lys Glu Arg Ala Arg Thr Val Gly 4640 4645 4650 Gly Val Ser Leu Leu Ser Thr Met Thr Thr Arg Gln Tyr His Gln 4655 4660 4665 Lys His Leu Lys Ser Ile Val Asn Thr Arg Gly Ala Ser Val Val 4670 4675 4680 Ile Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asp Asn Met Leu Lys 4685 4690 4695 Asn Leu Ile Asp Gly Val Glu Asn Pro Cys Leu Met Gly Trp Asp 4700 4705 4710 Tyr Pro Lys Cys Asp Arg Ala Leu Pro Asn Met Ile Arg Met Ile 4715 4720 4725 Ser Ala Met Ile Leu Gly Ser Lys His Thr Thr Cys Cys Ser Ser 4730 4735 4740 Thr Asp Arg Phe Phe Arg Leu Cys Asn Glu Leu Ala Gln Val Leu 4745 4750 4755 Thr Glu Val Val Tyr Ser Asn Gly Gly Phe Tyr Leu Lys Pro Gly 4760 4765 4770 Gly Thr Thr Ser Gly Asp Ala Thr Thr Ala Tyr Ala Asn Ser Val 4775 4780 4785 Phe Asn Ile Phe Gln Ala Val Ser Ala Asn Val Asn Lys Leu Leu 4790 4795 4800 Ser Val Asp Ser Asn Val Cys His Asn Leu Glu Val Lys Gln Leu 4805 4810 4815 Gln Arg Lys Leu Tyr Glu Cys Cys Tyr Arg Ser Thr Ile Val Asp 4820 4825 4830 Asp Gln Phe Val Val Glu Tyr Tyr Gly Tyr Leu Arg Lys His Phe 4835 4840 4845 Ser Met Met Ile Leu Ser Asp Asp Gly Val Val Cys Tyr Asn Asn 4850 4855 4860 Asp Tyr Ala Ser Leu Gly Tyr Val Ala Asp Leu Asn Ala Phe Lys 4865 4870 4875 Ala Val Leu Tyr Tyr Gln Asn Asn Val Phe Met Ser Ala Ser Lys 4880 4885 4890 Cys Trp Ile Glu Pro Asp Ile Asn Lys Gly Pro His Glu Phe Cys 4895 4900 4905 Ser Gln His Thr Met Gln Ile Val Asp Lys Glu Gly Thr Tyr Tyr 4910 4915 4920 Leu Pro Tyr Pro Asp Pro Ser Arg Ile Leu Ser Ala Gly Val Phe 4925 4930 4935 Val Asp Asp Val Val Lys Thr Asp Ala Val Val Leu Leu Glu Arg 4940 4945 4950 Tyr Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu Ser Lys His Glu 4955 4960 4965 Asn Pro Glu Tyr Lys Lys Val Phe Tyr Val Leu Leu Asp Trp Val 4970 4975 4980 Lys His Leu Tyr Lys Thr Leu Asn Ala Gly Val Leu Glu Ser Phe 4985 4990 4995 Ser Val Thr Leu Leu Glu Asp Ser Thr Ala Lys Phe Trp Asp Glu 5000 5005 5010 Ser Phe Tyr Ala Asn Met Tyr Glu Lys Ser Ala Val Leu Gln Ser 5015 5020 5025 Ala Gly Leu Cys Val Val Cys Gly Ser Gln Thr Val Leu Arg Cys 5030 5035 5040 Gly Asp Cys Leu Arg Arg Pro Met Leu Cys Thr Lys Cys Ala Tyr 5045 5050 5055 Asp His Val Ile Gly Thr Thr His Lys Phe Ile Leu Ala Ile Thr 5060 5065 5070 Pro Tyr Val Cys Cys Ala Ser Asp Cys Gly Val Asn Asp Val Thr 5075 5080 5085 Lys Leu Tyr Leu Gly Gly Leu Ser Tyr Trp Cys His Glu His Lys 5090 5095 5100 Pro Arg Leu Ala Phe Pro Leu Cys Ser Ala Gly Asn Val Phe Gly 5105 5110 5115 Leu Tyr Lys Asn Ser Ala Thr Gly Ser Pro Asp Val Glu Asp Phe 5120 5125 5130 Asn Arg Ile Ala Thr Ser Asp Trp Thr Asp Val Ser Asp Tyr Arg 5135 5140 5145 Leu Ala Asn Asp Val Lys Asp Ser Leu Arg Leu Phe Ala Ala Glu 5150 5155 5160 Thr Ile Lys Ala Lys Glu Glu Ser Val Lys Ser Ser Tyr Ala Cys 5165 5170 5175 Ala Thr Leu His Glu Val Val Gly Pro Lys Glu Leu Leu Leu Lys 5180 5185 5190 Trp Glu Val Gly Arg Pro Lys Pro Pro Leu Asn Arg Asn Ser Val 5195 5200 5205 Phe Thr Cys Tyr His Ile Thr Lys Asn Thr Lys Phe Gln Ile Gly 5210 5215 5220 Glu Phe Val Phe Glu Lys Ala Glu Tyr Asp Asn Asp Ala Val Thr 5225 5230 5235 Tyr Lys Thr Thr Ala Thr Thr Lys Leu Val Pro Gly Met Val Phe 5240 5245 5250 Val Leu Thr Ser His Asn Val Gln Pro Leu Arg Ala Pro Thr Ile 5255 5260 5265 Ala Asn Gln Glu Arg Tyr Ser Thr Ile His Lys Leu His Pro Ala 5270 5275 5280 Phe Asn Ile Pro Glu Ala Tyr Ser Ser Leu Val Pro Tyr Tyr Gln 5285 5290 5295 Leu Ile Gly Lys Gln Lys Ile Thr Thr Ile Gln Gly Pro Pro Gly 5300 5305 5310 Ser Gly Lys Ser His Cys Val Ile Gly Leu Gly Leu Tyr Tyr Pro 5315 5320 5325 Gly Ala Arg Ile Val Phe Thr Ala Cys Ser His Ala Ala Val Asp 5330 5335 5340 Ser Leu Cys Val Lys Ala Ser Thr Ala Tyr Ser Asn Asp Lys Cys 5345 5350 5355 Ser Arg Ile Ile Pro Gln Arg Ala Arg Val Glu Cys Tyr Asp Gly 5360 5365 5370 Phe Lys Ser Asn Asn Thr Ser Ala Gln Tyr Leu Phe Ser Thr Val 5375 5380 5385 Asn Ala Leu Pro Glu Cys Asn Ala Asp Ile Val Val Val Asp Glu 5390 5395 5400 Val Ser Met Cys Thr Asn Tyr Asp Leu Ser Val Ile Asn Gln Arg 5405 5410 5415 Ile Ser Tyr Arg His Val Val Tyr Val Gly Asp Pro Gln Gln Leu 5420 5425 5430 Pro Ala Pro Arg Val Met Ile Ser Arg Gly Thr Leu Glu Pro Lys 5435 5440 5445 Asp Tyr Asn Val Val Thr Gln Arg Met Cys Ala Leu Lys Pro Asp 5450 5455 5460 Val Phe Leu His Lys Cys Tyr Arg Cys Pro Ala Glu Ile Val Arg 5465 5470 5475 Thr Val Ser Glu Met Val Tyr Glu Asn Gln Phe Ile Pro Val His 5480 5485 5490 Pro Asp Ser Lys Gln Cys Phe Lys Ile Phe Cys Lys Gly Asn Val 5495 5500 5505 Gln Val Asp Asn Gly Ser Ser Ile Asn Arg Arg Gln Leu Asp Val 5510 5515 5520 Val Arg Met Phe Leu Ala Lys Asn Pro Arg Trp Ser Lys Ala Val 5525 5530 5535 Phe Ile Ser Pro Tyr Asn Ser Gln Asn Tyr Val Ala Ser Arg Leu 5540 5545 5550 Leu Gly Leu Gln Ile Gln Thr Val Asp Ser Ser Gln Gly Ser Glu 5555 5560 5565 Tyr Asp Tyr Val Ile Tyr Ala Gln Thr Ser Asp Thr Ala His Ala 5570 5575 5580 Ser Asn Val Asn Arg Phe Asn Val Ala Ile Thr Arg Ala Lys Lys 5585 5590 5595 Gly Ile Leu Cys Ile Met Cys Asp Arg Ser Leu Phe Asp Leu Leu 5600 5605 5610 Lys Phe Phe Glu Leu Lys Leu Ser Asp Leu Gln Ala Asn Glu Gly 5615 5620 5625 Cys Gly Leu Phe Lys Asp Cys Ser Arg Gly Asp Asp Leu Leu Pro 5630 5635 5640 Pro Ser His Ala Asn Thr Phe Met Ser Leu Ala Asp Asn Phe Lys 5645 5650 5655 Thr Asp Gln Tyr Leu Ala Val Gln Ile Gly Val Asn Gly Pro Ile 5660 5665 5670 Lys Tyr Glu His Val Ile Ser Phe Met Gly Phe Arg Phe Asp Ile 5675 5680 5685 Asn Ile Pro Asn His His Thr Leu Phe Cys Thr Arg Asp Phe Ala 5690 5695 5700 Met Arg Asn Val Arg Gly Trp Leu Gly Phe Asp Val Glu Gly Ala 5705 5710 5715 His Val Val Gly Ser Asn Val Gly Thr Asn Val Pro Leu Gln Leu 5720 5725 5730 Gly Phe Ser Asn Gly Val Asp Phe Val Val Arg Pro Glu Gly Cys 5735 5740 5745 Val Val Thr Glu Ser Gly Asp Tyr Ile Lys Pro Val Arg Ala Arg 5750 5755 5760 Ala Pro Pro Gly Glu Gln Phe Ala His Leu Leu Pro Leu Leu Lys 5765 5770 5775 Arg Gly Gln Pro Trp Asp Val Val Arg Lys Arg Ile Val Gln Met 5780 5785 5790 Cys Ser Asp Tyr Leu Ala Asn Leu Ser Asp Ile Leu Ile Phe Val 5795 5800 5805 Leu Trp Ala Gly Gly Leu Glu Leu Thr Thr Met Arg Tyr Phe Val 5810 5815 5820 Lys Ile Gly Pro Ser Lys Ser Cys Asp Cys Gly Lys Val Ala Thr 5825 5830 5835 Cys Tyr Asn Ser Ala Leu His Thr Tyr Cys Cys Phe Lys His Ala 5840 5845 5850 Leu Gly Cys Asp Tyr Leu Tyr Asn Pro Tyr Cys Ile Asp Ile Gln 5855 5860 5865 Gln Trp Gly Tyr Lys Gly Ser Leu Ser Leu Asn His His Glu His 5870 5875 5880 Cys Asn Val His Arg Asn Glu His Val Ala Ser Gly Asp Ala Ile 5885 5890 5895 Met Thr Arg Cys Leu Ala Ile His Asp Cys Phe Val Lys Asn Val 5900 5905 5910 Asp Trp Ser Ile Thr Tyr Pro Phe Ile Gly Asn Glu Ala Val Ile 5915 5920 5925 Asn Lys Ser Gly Arg Ile Val Gln Ser His Thr Met Arg Ser Val 5930 5935 5940 Leu Lys Leu Tyr Asn Pro Lys Ala Ile Tyr Asp Ile Gly Asn Pro 5945 5950 5955 Lys Gly Ile Arg Cys Ala Val Thr Asp Ala Lys Trp Phe Cys Phe 5960 5965 5970 Asp Lys Asn Pro Thr Asn Ser Asn Val Lys Thr Leu Glu Tyr Asp 5975 5980 5985 Tyr Ile Thr His Gly Gln Phe Asp Gly Leu Cys Leu Phe Trp Asn 5990 5995 6000 Cys Asn Val Asp Met Tyr Pro Glu Phe Ser Val Val Cys Arg Phe 6005 6010 6015 Asp Thr Arg Cys Arg Ser Pro Leu Asn Leu Glu Gly Cys Asn Gly 6020 6025 6030 Gly Ser Leu Tyr Val Asn Asn His Ala Phe His Thr Pro Ala Phe 6035 6040 6045 Asp Lys Arg Ala Phe Ala Lys Leu Lys Pro Met Pro Phe Phe Phe 6050 6055 6060 Tyr Asp Asp Thr Glu Cys Asp Lys Leu Gln Asp Ser Ile Asn Tyr 6065 6070 6075 Val Pro Leu Arg Ala Ser Asn Cys Ile Thr Lys Cys Asn Val Gly 6080 6085 6090 Gly Ala Val Cys Ser Lys His Cys Ala Met Tyr His Ser Tyr Val 6095 6100 6105 Asn Ala Tyr Asn Thr Phe Thr Ser Ala Gly Phe Thr Ile Trp Val 6110 6115 6120 Pro Thr Ser Phe Asp Thr Tyr Asn Leu Trp Gln Thr Phe Ser Asn 6125 6130 6135 Asn Leu Gln Gly Leu Glu Asn Ile Ala Phe Asn Val Leu Lys Lys 6140 6145 6150 Gly Ser Phe Val Gly Asp Glu Gly Glu Leu Pro Val Ala Val Val 6155 6160 6165 Asn Asp Lys Val Leu Val Arg Asp Gly Thr Val Asp Thr Leu Val 6170 6175 6180 Phe Thr Asn Lys Thr Ser Leu Pro Thr Asn Val Ala Phe Glu Leu 6185 6190 6195 Tyr Ala Lys Arg Lys Val Gly Leu Thr Pro Pro Ile Thr Ile Leu 6200 6205 6210 Arg Asn Leu Gly Val Val Cys Thr Ser Lys Cys Val Ile Trp Asp 6215 6220 6225 Tyr Glu Ala Glu Arg Pro Leu Thr Thr Phe Thr Lys Asp Val Cys 6230 6235 6240 Lys Tyr Thr Asp Phe Glu Gly Asp Val Cys Thr Leu Phe Asp Asn 6245 6250 6255 Ser Ile Val Gly Ser Leu Glu Arg Phe Ser Met Thr Gln Asn Ala 6260 6265 6270 Val Leu Met Ser Leu Thr Ala Val Lys Lys Leu Thr Gly Ile Lys 6275 6280 6285 Leu Thr Tyr Gly Tyr Leu Asn Gly Val Pro Val Asn Thr His Glu 6290 6295 6300 Asp Lys Pro Phe Thr Trp Tyr Ile Tyr Thr Arg Lys Asn Gly Lys 6305 6310 6315 Phe Glu Asp Tyr Pro Asp Gly Tyr Phe Thr Gln Gly Arg Thr Thr 6320 6325 6330 Ala Asp Phe Ser Pro Arg Ser Asp Met Glu Lys Asp Phe Leu Ser 6335 6340 6345 Met Asp Met Gly Leu Phe Ile Asn Lys Tyr Gly Leu Glu Asp Tyr 6350 6355 6360 Gly Phe Glu His Val Val Tyr Gly Asp Val Ser Lys Thr Thr Leu 6365 6370 6375 Gly Gly Leu His Leu Leu Ile Ser Gln Val Arg Leu Ala Cys Met 6380 6385 6390 Gly Val Leu Lys Ile Asp Glu Phe Val Ser Ser Asn Asp Ser Thr 6395 6400 6405 Leu Lys Ser Cys Thr Val Thr Tyr Ala Asp Asn Pro Ser Ser Lys 6410 6415 6420 Met Val Cys Thr Tyr Met Asp Leu Leu Leu Asp Asp Phe Val Ser 6425 6430 6435 Ile Leu Lys Ser Leu Asp Leu Ser Val Val Ser Lys Val His Glu 6440 6445 6450 Val Met Val Asp Cys Lys Met Trp Arg Trp Met Leu Trp Cys Lys 6455 6460 6465 Asp His Lys Leu Gln Thr Phe Tyr Pro Gln Leu Gln Ala Ser Glu 6470 6475 6480 Trp Lys Cys Gly Tyr Ser Met Pro Ser Ile Tyr Lys Ile Gln Arg 6485 6490 6495 Met Cys Leu Glu Pro Cys Asn Leu Tyr Asn Tyr Gly Ala Gly Val 6500 6505 6510 Lys Leu Pro Asp Gly Ile Met Phe Asn Val Val Lys Tyr Thr Gln 6515 6520 6525 Leu Cys Gln Tyr Leu Asn Ser Thr Thr Met Cys Val Pro His His 6530 6535 6540 Met Arg Val Leu His Leu Gly Ala Gly Ser Asp Lys Gly Val Ala 6545 6550 6555 Pro Gly Thr Ala Val Leu Arg Arg Trp Leu Pro Leu Asp Ala Ile 6560 6565 6570 Ile Val Asp Asn Asp Ser Val Asp Tyr Val Ser Asp Ala Asp Tyr 6575 6580 6585 Ser Val Thr Gly Asp Cys Ser Thr Leu Tyr Leu Ser Asp Lys Phe 6590 6595 6600 Asp Leu Val Ile Ser Asp Met Tyr Asp Gly Lys Ile Lys Ser Cys 6605 6610 6615 Asp Gly Glu Asn Val Ser Lys Glu Gly Phe Phe Pro Tyr Ile Asn 6620 6625 6630 Gly Val Ile Thr Glu Lys Leu Ala Leu Gly Gly Thr Val Ala Ile 6635 6640 6645 Lys Val Thr Glu Phe Ser Trp Asn Lys Lys Leu Tyr Glu Leu Ile 6650 6655 6660 Gln Lys Phe Glu Tyr Trp Thr Met Phe Cys Thr Ser Val Asn Thr 6665 6670 6675 Ser Ser Ser Glu Ala Phe Leu Ile Gly Val His Tyr Leu Gly Asp 6680 6685 6690 Phe Ala Ser Gly Ala Val Ile Asp Gly Asn Thr Met His Ala Asn 6695 6700 6705 Tyr Ile Phe Trp Arg Asn Ser Thr Ile Met Thr Met Ser Tyr Asn 6710 6715 6720 Ser Val Leu Asp Leu Ser Lys Phe Asn Cys Lys His Lys Ala Thr 6725 6730 6735 Val Val Val Asn Leu Lys Asp Ser Ser Ile Ser Asp Val Val Leu 6740 6745 6750 Gly Leu Leu Lys Asn Gly Lys Leu Leu Val Arg Asn Asn Asp Ala 6755 6760 6765 Ile Cys Gly Phe Ser Asn His Leu Val Asn Val Asn Lys 6770 6775 6780 <210> 27 <211> 7073 <212> PRT <213> human SARS virus <220> <221> MISC_FEATURE <223> ORF 1AB <400> 27 Met Glu Ser Leu Val Leu Gly Val Asn Glu Lys Thr His Val Gln Leu 1 5 10 15 Ser Leu Pro Val Leu Gln Val Arg Asp Val Leu Val Arg Gly Phe Gly 20 25 30 Asp Ser Val Glu Glu Ala Leu Ser Glu Ala Arg Glu His Leu Lys Asn 35 40 45 Gly Thr Cys Gly Leu Val Glu Leu Glu Lys Gly Val Leu Pro Gln Leu 50 55 60 Glu Gln Pro Tyr Val Phe Ile Lys Arg Ser Asp Ala Leu Ser Thr Asn 65 70 75 80 His Gly His Lys Val Val Glu Leu Val Ala Glu Met Asp Gly Ile Gln 85 90 95 Tyr Gly Arg Ser Gly Ile Thr Leu Gly Val Leu Val Pro His Val Gly 100 105 110 Glu Thr Pro Ile Ala Tyr Arg Asn Val Leu Leu Arg Lys Asn Gly Asn 115 120 125 Lys Gly Ala Gly Gly His Ser Tyr Gly Ile Asp Leu Lys Ser Tyr Asp 130 135 140 Leu Gly Asp Glu Leu Gly Thr Asp Pro Ile Glu Asp Tyr Glu Gln Asn 145 150 155 160 Trp Asn Thr Lys His Gly Ser Gly Ala Leu Arg Glu Leu Thr Arg Glu 165 170 175 Leu Asn Gly Gly Ala Val Thr Arg Tyr Val Asp Asn Asn Phe Cys Gly 180 185 190 Pro Asp Gly Tyr Pro Leu Asp Cys Ile Lys Asp Phe Leu Ala Arg Ala 195 200 205 Gly Lys Ser Met Cys Thr Leu Ser Glu Gln Leu Asp Tyr Ile Glu Ser 210 215 220 Lys Arg Gly Val Tyr Cys Cys Arg Asp His Glu His Glu Ile Ala Trp 225 230 235 240 Phe Thr Glu Arg Ser Asp Lys Ser Tyr Glu His Gln Thr Pro Phe Glu 245 250 255 Ile Lys Ser Ala Lys Lys Phe Asp Thr Phe Lys Gly Glu Cys Pro Lys 260 265 270 Phe Val Phe Pro Leu Asn Ser Lys Val Lys Val Ile Gln Pro Arg Val 275 280 285 Glu Lys Lys Lys Thr Glu Gly Phe Met Gly Arg Ile Arg Ser Val Tyr 290 295 300 Pro Val Ala Ser Pro Gln Glu Cys Asn Asn Met His Leu Ser Thr Leu 305 310 315 320 Met Lys Cys Asn His Cys Asp Glu Val Ser Trp Gln Thr Cys Asp Phe 325 330 335 Leu Lys Ala Thr Cys Glu His Cys Gly Thr Glu Asn Leu Val Ile Glu 340 345 350 Gly Pro Thr Thr Cys Gly Tyr Leu Pro Thr Asn Ala Val Val Lys Met 355 360 365 Pro Cys Pro Ala Cys Gln Asp Pro Glu Ile Gly Pro Glu His Ser Val 370 375 380 Ala Asp Tyr His Asn His Ser Asn Ile Glu Thr Arg Leu Arg Lys Gly 385 390 395 400 Gly Arg Thr Arg Cys Phe Gly Gly Cys Val Phe Ala Tyr Val Gly Cys 405 410 415 Tyr Asn Lys Arg Ala Tyr Trp Val Pro Arg Ala Ser Ala Asp Ile Gly 420 425 430 Ser Gly His Thr Gly Ile Thr Gly Asp Asn Val Glu Thr Leu Asn Glu 435 440 445 Asp Leu Leu Glu Ile Leu Ser Arg Glu Arg Val Asn Ile Asn Ile Val 450 455 460 Gly Asp Phe His Leu Asn Glu Glu Val Ala Ile Ile Leu Ala Ser Phe 465 470 475 480 Ser Ala Ser Thr Ser Ala Phe Ile Asp Thr Ile Lys Ser Leu Asp Tyr 485 490 495 Lys Ser Phe Lys Thr Ile Val Glu Ser Cys Gly Asn Tyr Lys Val Thr 500 505 510 Lys Gly Lys Pro Val Lys Gly Ala Trp Asn Ile Gly Gln Gln Arg Ser 515 520 525 Val Leu Thr Pro Leu Cys Gly Phe Pro Ser Gln Ala Ala Gly Val Ile 530 535 540 Arg Ser Ile Phe Ala Arg Thr Leu Asp Ala Ala Asn His Ser Ile Pro 545 550 555 560 Asp Leu Gln Arg Ala Ala Val Thr Ile Leu Asp Gly Ile Ser Glu Gln 565 570 575 Ser Leu Arg Leu Val Asp Ala Met Val Tyr Thr Ser Asp Leu Leu Thr 580 585 590 Asn Ser Val Ile Ile Met Ala Tyr Val Thr Gly Gly Leu Val Gln Gln 595 600 605 Thr Ser Gln Trp Leu Ser Asn Leu Leu Gly Thr Thr Val Glu Lys Leu 610 615 620 Arg Pro Ile Phe Glu Trp Ile Glu Ala Lys Leu Ser Ala Gly Val Glu 625 630 635 640 Phe Leu Lys Asp Ala Trp Glu Ile Leu Lys Phe Leu Ile Thr Gly Val 645 650 655 Phe Asp Ile Val Lys Gly Gln Ile Gln Val Ala Ser Asp Asn Ile Lys 660 665 670 Asp Cys Val Lys Cys Phe Ile Asp Val Val Asn Lys Ala Leu Glu Met 675 680 685 Cys Ile Asp Gln Val Thr Ile Ala Gly Ala Lys Leu Arg Ser Leu Asn 690 695 700 Leu Gly Glu Val Phe Ile Ala Gln Ser Lys Gly Leu Tyr Arg Gln Cys 705 710 715 720 Ile Arg Gly Lys Glu Gln Leu Gln Leu Leu Met Pro Leu Lys Ala Pro 725 730 735 Lys Glu Val Thr Phe Leu Glu Gly Asp Ser His Asp Thr Val Leu Thr 740 745 750 Ser Glu Glu Val Val Leu Lys Asn Gly Glu Leu Glu Ala Leu Glu Thr 755 760 765 Pro Val Asp Ser Phe Thr Asn Gly Ala Ile Val Gly Thr Pro Val Cys 770 775 780 Val Asn Gly Leu Met Leu Leu Glu Ile Lys Asp Lys Glu Gln Tyr Cys 785 790 795 800 Ala Leu Ser Pro Gly Leu Leu Ala Thr Asn Asn Val Phe Arg Leu Lys 805 810 815 Gly Gly Ala Pro Ile Lys Gly Val Thr Phe Gly Glu Asp Thr Val Trp 820 825 830 Glu Val Gln Gly Tyr Lys Asn Val Arg Ile Thr Phe Glu Leu Asp Glu 835 840 845 Arg Val Asp Lys Val Leu Asn Glu Lys Cys Ser Val Tyr Thr Val Glu 850 855 860 Ser Gly Thr Glu Val Thr Glu Phe Ala Cys Val Val Ala Glu Ala Val 865 870 875 880 Val Lys Thr Leu Gln Pro Val Ser Asp Leu Leu Thr Asn Met Gly Ile 885 890 895 Asp Leu Asp Glu Trp Ser Val Ala Thr Phe Tyr Leu Phe Asp Asp Ala 900 905 910 Gly Glu Glu Asn Phe Ser Ser Arg Met Tyr Cys Ser Phe Tyr Pro Pro 915 920 925 Asp Glu Glu Glu Glu Asp Asp Ala Glu Cys Glu Glu Glu Glu Ile Asp 930 935 940 Glu Thr Cys Glu His Glu Tyr Gly Thr Glu Asp Asp Tyr Gln Gly Leu 945 950 955 960 Pro Leu Glu Phe Gly Ala Ser Ala Glu Thr Val Arg Val Glu Glu Glu 965 970 975 Glu Glu Glu Asp Trp Leu Asp Asp Thr Thr Glu Gln Ser Glu Ile Glu 980 985 990 Pro Glu Pro Glu Pro Thr Pro Glu Glu Pro Val Asn Gln Phe Thr Gly 995 1000 1005 Tyr Leu Lys Leu Thr Asp Asn Val Ala Ile Lys Cys Val Asp Ile 1010 1015 1020 Val Lys Glu Ala Gln Ser Ala Asn Pro Met Val Ile Val Asn Ala 1025 1030 1035 Ala Asn Ile His Leu Lys His Gly Gly Gly Val Ala Gly Ala Leu 1040 1045 1050 Asn Lys Ala Thr Asn Gly Ala Met Gln Lys Glu Ser Asp Asp Tyr 1055 1060 1065 Ile Lys Leu Asn Gly Pro Leu Thr Val Gly Gly Ser Cys Leu Leu 1070 1075 1080 Ser Gly His Asn Leu Ala Lys Lys Cys Leu His Val Val Gly Pro 1085 1090 1095 Asn Leu Asn Ala Gly Glu Asp Ile Gln Leu Leu Lys Ala Ala Tyr 1100 1105 1110 Glu Asn Phe Asn Ser Gln Asp Ile Leu Leu Ala Pro Leu Leu Ser 1115 1120 1125 Ala Gly Ile Phe Gly Ala Lys Pro Leu Gln Ser Leu Gln Val Cys 1130 1135 1140 Val Gln Thr Val Arg Thr Gln Val Tyr Ile Ala Val Asn Asp Lys 1145 1150 1155 Ala Leu Tyr Glu Gln Val Val Met Asp Tyr Leu Asp Asn Leu Lys 1160 1165 1170 Pro Arg Val Glu Ala Pro Lys Gln Glu Glu Pro Pro Asn Thr Glu 1175 1180 1185 Asp Ser Lys Thr Glu Glu Lys Ser Val Val Gln Lys Pro Val Asp 1190 1195 1200 Val Lys Pro Lys Ile Lys Ala Cys Ile Asp Glu Val Thr Thr Thr 1205 1210 1215 Leu Glu Glu Thr Lys Phe Leu Thr Asn Lys Leu Leu Leu Phe Ala 1220 1225 1230 Asp Ile Asn Gly Lys Leu Tyr His Asp Ser Gln Asn Met Leu Arg 1235 1240 1245 Gly Glu Asp Met Ser Phe Leu Glu Lys Asp Ala Pro Tyr Met Val 1250 1255 1260 Gly Asp Val Ile Thr Ser Gly Asp Ile Thr Cys Val Val Ile Pro 1265 1270 1275 Ser Lys Lys Ala Gly Gly Thr Thr Glu Met Leu Ser Arg Ala Leu 1280 1285 1290 Lys Lys Val Pro Val Asp Glu Tyr Ile Thr Thr Tyr Pro Gly Gln 1295 1300 1305 Gly Cys Ala Gly Tyr Thr Leu Glu Glu Ala Lys Thr Ala Leu Lys 1310 1315 1320 Lys Cys Lys Ser Ala Phe Tyr Val Leu Pro Ser Glu Ala Pro Asn 1325 1330 1335 Ala Lys Glu Glu Ile Leu Gly Thr Val Ser Trp Asn Leu Arg Glu 1340 1345 1350 Met Leu Ala His Ala Glu Glu Thr Arg Lys Leu Met Pro Ile Cys 1355 1360 1365 Met Asp Val Arg Ala Ile Met Ala Thr Ile Gln Arg Lys Tyr Lys 1370 1375 1380 Gly Ile Lys Ile Gln Glu Gly Ile Val Asp Tyr Gly Val Arg Phe 1385 1390 1395 Phe Phe Tyr Thr Ser Lys Glu Pro Val Ala Ser Ile Ile Thr Lys 1400 1405 1410 Leu Asn Ser Leu Asn Glu Pro Leu Val Thr Met Pro Ile Gly Tyr 1415 1420 1425 Val Thr His Gly Phe Asn Leu Glu Glu Ala Ala Arg Cys Met Arg 1430 1435 1440 Ser Leu Lys Ala Pro Ala Val Val Ser Val Ser Ser Pro Asp Ala 1445 1450 1455 Val Thr Thr Tyr Asn Gly Tyr Leu Thr Ser Ser Ser Lys Thr Ser 1460 1465 1470 Glu Glu His Phe Val Glu Thr Val Ser Leu Ala Gly Ser Tyr Arg 1475 1480 1485 Asp Trp Ser Tyr Ser Gly Gln Arg Thr Glu Leu Gly Val Glu Phe 1490 1495 1500 Leu Lys Arg Gly Asp Lys Ile Val Tyr His Thr Leu Glu Ser Pro 1505 1510 1515 Val Glu Phe His Leu Asp Gly Glu Val Leu Ser Leu Asp Lys Leu 1520 1525 1530 Lys Ser Leu Leu Ser Leu Arg Glu Val Lys Thr Ile Lys Val Phe 1535 1540 1545 Thr Thr Val Asp Asn Thr Asn Leu His Thr Gln Leu Val Asp Met 1550 1555 1560 Ser Met Thr Tyr Gly Gln Gln Phe Gly Pro Thr Tyr Leu Asp Gly 1565 1570 1575 Ala Asp Val Thr Lys Ile Lys Pro His Val Asn His Glu Gly Lys 1580 1585 1590 Thr Phe Phe Val Leu Pro Ser Asp Asp Thr Leu Arg Ser Glu Ala 1595 1600 1605 Phe Glu Tyr Tyr His Thr Leu Asp Glu Ser Phe Leu Gly Arg Tyr 1610 1615 1620 Met Ser Ala Leu Asn His Thr Lys Lys Trp Lys Phe Pro Gln Val 1625 1630 1635 Gly Gly Leu Thr Ser Ile Lys Trp Ala Asp Asn Asn Cys Tyr Leu 1640 1645 1650 Ser Ser Val Leu Leu Ala Leu Gln Gln Leu Glu Val Lys Phe Asn 1655 1660 1665 Ala Pro Ala Leu Gln Glu Ala Tyr Tyr Arg Ala Arg Ala Gly Asp 1670 1675 1680 Ala Ala Asn Phe Cys Ala Leu Ile Leu Ala Tyr Ser Asn Lys Thr 1685 1690 1695 Val Gly Glu Leu Gly Asp Val Arg Glu Thr Met Thr His Leu Leu 1700 1705 1710 Gln His Ala Asn Leu Glu Ser Ala Lys Arg Val Leu Asn Val Val 1715 1720 1725 Cys Lys His Cys Gly Gln Lys Thr Thr Thr Leu Thr Gly Val Glu 1730 1735 1740 Ala Val Met Tyr Met Gly Thr Leu Ser Tyr Asp Asn Leu Lys Thr 1745 1750 1755 Gly Val Ser Ile Pro Cys Val Cys Gly Arg Asp Ala Thr Gln Tyr 1760 1765 1770 Leu Val Gln Gln Glu Ser Ser Phe Val Met Met Ser Ala Pro Pro 1775 1780 1785 Ala Glu Tyr Lys Leu Gln Gln Gly Thr Phe Leu Cys Ala Asn Glu 1790 1795 1800 Tyr Thr Gly Asn Tyr Gln Cys Gly His Tyr Thr His Ile Thr Ala 1805 1810 1815 Lys Glu Thr Leu Tyr Arg Ile Asp Gly Ala His Leu Thr Lys Met 1820 1825 1830 Ser Glu Tyr Lys Gly Pro Val Thr Asp Val Phe Tyr Lys Glu Thr 1835 1840 1845 Ser Tyr Thr Thr Thr Ile Lys Pro Val Ser Tyr Lys Leu Asp Gly 1850 1855 1860 Val Thr Tyr Thr Glu Ile Glu Pro Lys Leu Asp Gly Tyr Tyr Lys 1865 1870 1875 Lys Asp Asn Ala Tyr Tyr Thr Glu Gln Pro Ile Asp Leu Val Pro 1880 1885 1890 Thr Gln Pro Leu Pro Asn Ala Ser Phe Asp Asn Phe Lys Leu Thr 1895 1900 1905 Cys Ser Asn Thr Lys Phe Ala Asp Asp Leu Asn Gln Met Thr Gly 1910 1915 1920 Phe Thr Lys Pro Ala Ser Arg Glu Leu Ser Val Thr Phe Phe Pro 1925 1930 1935 Asp Leu Asn Gly Asp Val Val Ala Ile Asp Tyr Arg His Tyr Ser 1940 1945 1950 Ala Ser Phe Lys Lys Gly Ala Lys Leu Leu His Lys Pro Ile Val 1955 1960 1965 Trp His Ile Asn Gln Ala Thr Thr Lys Thr Thr Phe Lys Pro Asn 1970 1975 1980 Thr Trp Cys Leu Arg Cys Leu Trp Ser Thr Lys Pro Val Asp Thr 1985 1990 1995 Ser Asn Ser Phe Glu Val Leu Ala Val Glu Asp Thr Gln Gly Met 2000 2005 2010 Asp Asn Leu Ala Cys Glu Ser Gln Gln Pro Thr Ser Glu Glu Val 2015 2020 2025 Val Glu Asn Pro Thr Ile Gln Lys Glu Val Ile Glu Cys Asp Val 2030 2035 2040 Lys Thr Thr Glu Val Val Gly Asn Val Ile Leu Lys Pro Ser Asp 2045 2050 2055 Glu Gly Val Lys Val Thr Gln Glu Leu Gly His Glu Asp Leu Met 2060 2065 2070 Ala Ala Tyr Val Glu Asn Thr Ser Ile Thr Ile Lys Lys Pro Asn 2075 2080 2085 Glu Leu Ser Leu Ala Leu Gly Leu Lys Thr Ile Ala Thr His Gly 2090 2095 2100 Ile Ala Ala Ile Asn Ser Val Pro Trp Ser Lys Ile Leu Ala Tyr 2105 2110 2115 Val Lys Pro Phe Leu Gly Gln Ala Ala Ile Thr Thr Ser Asn Cys 2120 2125 2130 Ala Lys Arg Leu Ala Gln Arg Val Phe Asn Asn Tyr Met Pro Tyr 2135 2140 2145 Val Phe Thr Leu Leu Phe Gln Leu Cys Thr Phe Thr Lys Ser Thr 2150 2155 2160 Asn Ser Arg Ile Arg Ala Ser Leu Pro Thr Thr Ile Ala Lys Asn 2165 2170 2175 Ser Val Lys Ser Val Ala Lys Leu Cys Leu Asp Ala Gly Ile Asn 2180 2185 2190 Tyr Val Lys Ser Pro Lys Phe Ser Lys Leu Phe Thr Ile Ala Met 2195 2200 2205 Trp Leu Leu Leu Leu Ser Ile Cys Leu Gly Ser Leu Ile Cys Val 2210 2215 2220 Thr Ala Ala Phe Gly Val Leu Leu Ser Asn Phe Gly Ala Pro Ser 2225 2230 2235 Tyr Cys Asn Gly Val Arg Glu Leu Tyr Leu Asn Ser Ser Asn Val 2240 2245 2250 Thr Thr Met Asp Phe Cys Glu Gly Ser Phe Pro Cys Ser Ile Cys 2255 2260 2265 Leu Ser Gly Leu Asp Ser Leu Asp Ser Tyr Pro Ala Leu Glu Thr 2270 2275 2280 Ile Gln Val Thr Ile Ser Ser Tyr Lys Leu Asp Leu Thr Ile Leu 2285 2290 2295 Gly Leu Ala Ala Glu Trp Val Leu Ala Tyr Met Leu Phe Thr Lys 2300 2305 2310 Phe Phe Tyr Leu Leu Gly Leu Ser Ala Ile Met Gln Val Phe Phe 2315 2320 2325 Gly Tyr Phe Ala Ser His Phe Ile Ser Asn Ser Trp Leu Met Trp 2330 2335 2340 Phe Ile Ile Ser Ile Val Gln Met Ala Pro Val Ser Ala Met Val 2345 2350 2355 Arg Met Tyr Ile Phe Phe Ala Ser Phe Tyr Tyr Ile Trp Lys Ser 2360 2365 2370 Tyr Val His Ile Met Asp Gly Cys Thr Ser Ser Thr Cys Met Met 2375 2380 2385 Cys Tyr Lys Arg Asn Arg Ala Thr Arg Val Glu Cys Thr Thr Ile 2390 2395 2400 Val Asn Gly Met Lys Arg Ser Phe Tyr Val Tyr Ala Asn Gly Gly 2405 2410 2415 Arg Gly Phe Cys Lys Thr His Asn Trp Asn Cys Leu Asn Cys Asp 2420 2425 2430 Thr Phe Cys Thr Gly Ser Thr Phe Ile Ser Asp Glu Val Ala Arg 2435 2440 2445 Asp Leu Ser Leu Gln Phe Lys Arg Pro Ile Asn Pro Thr Asp Gln 2450 2455 2460 Ser Ser Tyr Ile Val Asp Ser Val Ala Val Lys Asn Gly Ala Leu 2465 2470 2475 His Leu Tyr Phe Asp Lys Ala Gly Gln Lys Thr Tyr Glu Arg His 2480 2485 2490 Pro Leu Ser His Phe Val Asn Leu Asp Asn Leu Arg Ala Asn Asn 2495 2500 2505 Thr Lys Gly Ser Leu Pro Ile Asn Val Ile Val Phe Asp Gly Lys 2510 2515 2520 Ser Lys Cys Asp Glu Ser Ala Ser Lys Ser Ala Ser Val Tyr Tyr 2525 2530 2535 Ser Gln Leu Met Cys Gln Pro Ile Leu Leu Leu Asp Gln Val Leu 2540 2545 2550 Val Ser Asp Val Gly Asp Ser Thr Glu Val Ser Val Lys Met Phe 2555 2560 2565 Asp Ala Tyr Val Asp Thr Phe Ser Ala Thr Phe Ser Val Pro Met 2570 2575 2580 Glu Lys Leu Lys Ala Leu Val Ala Thr Ala His Ser Glu Leu Ala 2585 2590 2595 Lys Gly Val Ala Leu Asp Gly Val Leu Ser Thr Phe Val Ser Ala 2600 2605 2610 Ala Arg Gln Gly Val Val Asp Thr Asp Val Asp Thr Lys Asp Val 2615 2620 2625 Ile Glu Cys Leu Lys Leu Ser His His Ser Asp Leu Glu Val Thr 2630 2635 2640 Gly Asp Ser Cys Asn Asn Phe Met Leu Thr Tyr Asn Lys Val Glu 2645 2650 2655 Asn Met Thr Pro Arg Asp Leu Gly Ala Cys Ile Asp Cys Asn Ala 2660 2665 2670 Arg His Ile Asn Ala Gln Val Ala Lys Ser His Asn Val Ser Leu 2675 2680 2685 Ile Trp Asn Val Lys Asp Tyr Met Ser Leu Ser Glu Gln Leu Arg 2690 2695 2700 Lys Gln Ile Arg Ser Ala Ala Lys Lys Asn Asn Ile Pro Phe Arg 2705 2710 2715 Leu Thr Cys Ala Thr Thr Arg Gln Val Val Asn Val Ile Thr Thr 2720 2725 2730 Lys Ile Ser Leu Lys Gly Gly Lys Ile Val Ser Thr Cys Phe Lys 2735 2740 2745 Leu Met Leu Lys Ala Thr Leu Leu Cys Val Leu Ala Ala Leu Val 2750 2755 2760 Cys Tyr Ile Val Met Pro Val His Thr Leu Ser Ile His Asp Gly 2765 2770 2775 Tyr Thr Asn Glu Ile Ile Gly Tyr Lys Ala Ile Gln Asp Gly Val 2780 2785 2790 Thr Arg Asp Ile Ile Ser Thr Asp Asp Cys Phe Ala Asn Lys His 2795 2800 2805 Ala Gly Phe Asp Ala Trp Phe Ser Gln Arg Gly Gly Ser Tyr Lys 2810 2815 2820 Asn Asp Lys Ser Cys Pro Val Val Ala Ala Ile Ile Thr Arg Glu 2825 2830 2835 Ile Gly Phe Ile Val Pro Gly Leu Pro Gly Thr Val Leu Arg Ala 2840 2845 2850 Ile Asn Gly Asp Phe Leu His Phe Leu Pro Arg Val Phe Ser Ala 2855 2860 2865 Val Gly Asn Ile Cys Tyr Thr Pro Ser Lys Leu Ile Glu Tyr Ser 2870 2875 2880 Asp Phe Ala Thr Ser Ala Cys Val Leu Ala Ala Glu Cys Thr Ile 2885 2890 2895 Phe Lys Asp Ala Met Gly Lys Pro Val Pro Tyr Cys Tyr Asp Thr 2900 2905 2910 Asn Leu Leu Glu Gly Ser Ile Ser Tyr Ser Glu Leu Arg Pro Asp 2915 2920 2925 Thr Arg Tyr Val Leu Met Asp Gly Ser Ile Ile Gln Phe Pro Asn 2930 2935 2940 Thr Tyr Leu Glu Gly Ser Val Arg Val Val Thr Thr Phe Asp Ala 2945 2950 2955 Glu Tyr Cys Arg His Gly Thr Cys Glu Arg Ser Glu Val Gly Ile 2960 2965 2970 Cys Leu Ser Thr Ser Gly Arg Trp Val Leu Asn Asn Glu His Tyr 2975 2980 2985 Arg Ala Leu Ser Gly Val Phe Cys Gly Val Asp Ala Met Asn Leu 2990 2995 3000 Ile Ala Asn Ile Phe Thr Pro Leu Val Gln Pro Val Gly Ala Leu 3005 3010 3015 Asp Val Ser Ala Ser Val Val Ala Gly Gly Ile Ile Ala Ile Leu 3020 3025 3030 Val Thr Cys Ala Ala Tyr Tyr Phe Met Lys Phe Arg Arg Val Phe 3035 3040 3045 Gly Glu Tyr Asn His Val Val Ala Ala Asn Ala Leu Leu Phe Leu 3050 3055 3060 Met Ser Phe Thr Ile Leu Cys Leu Val Pro Ala Tyr Ser Phe Leu 3065 3070 3075 Pro Gly Val Tyr Ser Val Phe Tyr Leu Tyr Leu Thr Phe Tyr Phe 3080 3085 3090 Thr Asn Asp Val Ser Phe Leu Ala His Leu Gln Trp Phe Ala Met 3095 3100 3105 Phe Ser Pro Ile Val Pro Phe Trp Ile Thr Ala Ile Tyr Val Phe 3110 3115 3120 Cys Ile Ser Leu Lys His Cys His Trp Phe Phe Asn Asn Tyr Leu 3125 3130 3135 Arg Lys Arg Val Met Phe Asn Gly Val Thr Phe Ser Thr Phe Glu 3140 3145 3150 Glu Ala Ala Leu Cys Thr Phe Leu Leu Asn Lys Glu Met Tyr Leu 3155 3160 3165 Lys Leu Arg Ser Glu Thr Leu Leu Pro Leu Thr Gln Tyr Asn Arg 3170 3175 3180 Tyr Leu Ala Leu Tyr Asn Lys Tyr Lys Tyr Phe Ser Gly Ala Leu 3185 3190 3195 Asp Thr Thr Ser Tyr Arg Glu Ala Ala Cys Cys His Leu Ala Lys 3200 3205 3210 Ala Leu Asn Asp Phe Ser Asn Ser Gly Ala Asp Val Leu Tyr Gln 3215 3220 3225 Pro Pro Gln Thr Ser Ile Thr Ser Ala Val Leu Gln Ser Gly Phe 3230 3235 3240 Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys Met Val 3245 3250 3255 Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu Asp 3260 3265 3270 Asp Thr Val Tyr Cys Pro Arg His Val Ile Cys Thr Ala Glu Asp 3275 3280 3285 Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn 3290 3295 3300 His Ser Phe Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile 3305 3310 3315 Gly His Ser Met Gln Asn Cys Leu Leu Arg Leu Lys Val Asp Thr 3320 3325 3330 Ser Asn Pro Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro 3335 3340 3345 Gly Gln Thr Phe Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser 3350 3355 3360 Gly Val Tyr Gln Cys Ala Met Arg Pro Asn His Thr Ile Lys Gly 3365 3370 3375 Ser Phe Leu Asn Gly Ser Cys Gly Ser Val Gly Phe Asn Ile Asp 3380 3385 3390 Tyr Asp Cys Val Ser Phe Cys Tyr Met His His Met Glu Leu Pro 3395 3400 3405 Thr Gly Val His Ala Gly Thr Asp Leu Glu Gly Lys Phe Tyr Gly 3410 3415 3420 Pro Phe Val Asp Arg Gln Thr Ala Gln Ala Ala Gly Thr Asp Thr 3425 3430 3435 Thr Ile Thr Leu Asn Val Leu Ala Trp Leu Tyr Ala Ala Val Ile 3440 3445 3450 Asn Gly Asp Arg Trp Phe Leu Asn Arg Phe Thr Thr Thr Leu Asn 3455 3460 3465 Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu Pro Leu Thr 3470 3475 3480 Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln Thr Gly 3485 3490 3495 Ile Ala Val Leu Asp Met Cys Ala Ala Leu Lys Glu Leu Leu Gln 3500 3505 3510 Asn Gly Met Asn Gly Arg Thr Ile Leu Gly Ser Thr Ile Leu Glu 3515 3520 3525 Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val 3530 3535 3540 Thr Phe Gln Gly Lys Phe Lys Lys Ile Val Lys Gly Thr His His 3545 3550 3555 Trp Met Leu Leu Thr Phe Leu Thr Ser Leu Leu Ile Leu Val Gln 3560 3565 3570 Ser Thr Gln Trp Ser Leu Phe Phe Phe Val Tyr Glu Asn Ala Phe 3575 3580 3585 Leu Pro Phe Thr Leu Gly Ile Met Ala Ile Ala Ala Cys Ala Met 3590 3595 3600 Leu Leu Val Lys His Lys His Ala Phe Leu Cys Leu Phe Leu Leu 3605 3610 3615 Pro Ser Leu Ala Thr Val Ala Tyr Phe Asn Met Val Tyr Met Pro 3620 3625 3630 Ala Ser Trp Val Met Arg Ile Met Thr Trp Leu Glu Leu Ala Asp 3635 3640 3645 Thr Ser Leu Ser Gly Tyr Arg Leu Lys Asp Cys Val Met Tyr Ala 3650 3655 3660 Ser Ala Leu Val Leu Leu Ile Leu Met Thr Ala Arg Thr Val Tyr 3665 3670 3675 Asp Asp Ala Ala Arg Arg Val Trp Thr Leu Met Asn Val Ile Thr 3680 3685 3690 Leu Val Tyr Lys Val Tyr Tyr Gly Asn Ala Leu Asp Gln Ala Ile 3695 3700 3705 Ser Met Trp Ala Leu Val Ile Ser Val Thr Ser Asn Tyr Ser Gly 3710 3715 3720 Val Val Thr Thr Ile Met Phe Leu Ala Arg Ala Ile Val Phe Val 3725 3730 3735 Cys Val Glu Tyr Tyr Pro Leu Leu Phe Ile Thr Gly Asn Thr Leu 3740 3745 3750 Gln Cys Ile Met Leu Val Tyr Cys Phe Leu Gly Tyr Cys Cys Cys 3755 3760 3765 Cys Tyr Phe Gly Leu Phe Cys Leu Leu Asn Arg Tyr Phe Arg Leu 3770 3775 3780 Thr Leu Gly Val Tyr Asp Tyr Leu Val Ser Thr Gln Glu Phe Arg 3785 3790 3795 Tyr Met Asn Ser Gln Gly Leu Leu Pro Pro Lys Ser Ser Ile Asp 3800 3805 3810 Ala Phe Lys Leu Asn Ile Lys Leu Leu Gly Ile Gly Gly Lys Pro 3815 3820 3825 Cys Ile Lys Val Ala Thr Val Gln Ser Lys Met Ser Asp Val Lys 3830 3835 3840 Cys Thr Ser Val Val Leu Leu Ser Val Leu Gln Gln Leu Arg Val 3845 3850 3855 Glu Ser Ser Ser Lys Leu Trp Ala Gln Cys Val Gln Leu His Asn 3860 3865 3870 Asp Ile Leu Leu Ala Lys Asp Thr Thr Glu Ala Phe Glu Lys Met 3875 3880 3885 Val Ser Leu Leu Ser Val Leu Leu Ser Met Gln Gly Ala Val Asp 3890 3895 3900 Ile Asn Arg Leu Cys Glu Glu Met Leu Asp Asn Arg Ala Thr Leu 3905 3910 3915 Gln Ala Ile Ala Ser Glu Phe Ser Ser Leu Pro Ser Tyr Ala Ala 3920 3925 3930 Tyr Ala Thr Ala Gln Glu Ala Tyr Glu Gln Ala Val Ala Asn Gly 3935 3940 3945 Asp Ser Glu Val Val Leu Lys Lys Leu Lys Lys Ser Leu Asn Val 3950 3955 3960 Ala Lys Ser Glu Phe Asp Arg Asp Ala Ala Met Gln Arg Lys Leu 3965 3970 3975 Glu Lys Met Ala Asp Gln Ala Met Thr Gln Met Tyr Lys Gln Ala 3980 3985 3990 Arg Ser Glu Asp Lys Arg Ala Lys Val Thr Ser Ala Met Gln Thr 3995 4000 4005 Met Leu Phe Thr Met Leu Arg Lys Leu Asp Asn Asp Ala Leu Asn 4010 4015 4020 Asn Ile Ile Asn Asn Ala Arg Asp Gly Cys Val Pro Leu Asn Ile 4025 4030 4035 Ile Pro Leu Thr Thr Ala Ala Lys Leu Met Val Val Val Pro Asp 4040 4045 4050 Tyr Gly Thr Tyr Lys Asn Thr Cys Asp Gly Asn Thr Phe Thr Tyr 4055 4060 4065 Ala Ser Ala Leu Trp Glu Ile Gln Gln Val Val Asp Ala Asp Ser 4070 4075 4080 Lys Ile Val Gln Leu Ser Glu Ile Asn Met Asp Asn Ser Pro Asn 4085 4090 4095 Leu Ala Trp Pro Leu Ile Val Thr Ala Leu Arg Ala Asn Ser Ala 4100 4105 4110 Val Lys Leu Gln Asn Asn Glu Leu Ser Pro Val Ala Leu Arg Gln 4115 4120 4125 Met Ser Cys Ala Ala Gly Thr Thr Gln Thr Ala Cys Thr Asp Asp 4130 4135 4140 Asn Ala Leu Ala Tyr Tyr Asn Asn Ser Lys Gly Gly Arg Phe Val 4145 4150 4155 Leu Ala Leu Leu Ser Asp His Gln Asp Leu Lys Trp Ala Arg Phe 4160 4165 4170 Pro Lys Ser Asp Gly Thr Gly Thr Ile Tyr Thr Glu Leu Glu Pro 4175 4180 4185 Pro Cys Arg Phe Val Thr Asp Thr Pro Lys Gly Pro Lys Val Lys 4190 4195 4200 Tyr Leu Tyr Phe Ile Lys Gly Leu Asn Asn Leu Asn Arg Gly Met 4205 4210 4215 Val Leu Gly Ser Leu Ala Ala Thr Val Arg Leu Gln Ala Gly Asn 4220 4225 4230 Ala Thr Glu Val Pro Ala Asn Ser Thr Val Leu Ser Phe Cys Ala 4235 4240 4245 Phe Ala Val Asp Pro Ala Lys Ala Tyr Lys Asp Tyr Leu Ala Ser 4250 4255 4260 Gly Gly Gln Pro Ile Thr Asn Cys Val Lys Met Leu Cys Thr His 4265 4270 4275 Thr Gly Thr Gly Gln Ala Ile Thr Val Thr Pro Glu Ala Asn Met 4280 4285 4290 Asp Gln Glu Ser Phe Gly Gly Ala Ser Cys Cys Leu Tyr Cys Arg 4295 4300 4305 Cys His Ile Asp His Pro Asn Pro Lys Gly Phe Cys Asp Leu Lys 4310 4315 4320 Gly Lys Tyr Val Gln Ile Pro Thr Thr Cys Ala Asn Asp Pro Val 4325 4330 4335 Gly Phe Thr Leu Arg Asn Thr Val Cys Thr Val Cys Gly Met Trp 4340 4345 4350 Lys Gly Tyr Gly Cys Ser Cys Asp Gln Leu Arg Glu Pro Leu Met 4355 4360 4365 Gln Ser Ala Asp Ala Ser Thr Phe Leu Asn Arg Val Cys Gly Val 4370 4375 4380 Ser Ala Ala Arg Leu Thr Pro Cys Gly Thr Gly Thr Ser Thr Asp 4385 4390 4395 Val Val Tyr Arg Ala Phe Asp Ile Tyr Asn Glu Lys Val Ala Gly 4400 4405 4410 Phe Ala Lys Phe Leu Lys Thr Asn Cys Cys Arg Phe Gln Glu Lys 4415 4420 4425 Asp Glu Glu Gly Asn Leu Leu Asp Ser Tyr Phe Val Val Lys Arg 4430 4435 4440 His Thr Met Ser Asn Tyr Gln His Glu Glu Thr Ile Tyr Asn Leu 4445 4450 4455 Val Lys Asp Cys Pro Ala Val Ala Val His Asp Phe Phe Lys Phe 4460 4465 4470 Arg Val Asp Gly Asp Met Val Pro His Ile Ser Arg Gln Arg Leu 4475 4480 4485 Thr Lys Tyr Thr Met Ala Asp Leu Val Tyr Ala Leu Arg His Phe 4490 4495 4500 Asp Glu Gly Asn Cys Asp Thr Leu Lys Glu Ile Leu Val Thr Tyr 4505 4510 4515 Asn Cys Cys Asp Asp Asp Tyr Phe Asn Lys Lys Asp Trp Tyr Asp 4520 4525 4530 Phe Val Glu Asn Pro Asp Ile Leu Arg Val Tyr Ala Asn Leu Gly 4535 4540 4545 Glu Arg Val Arg Gln Ser Leu Leu Lys Thr Val Gln Phe Cys Asp 4550 4555 4560 Ala Met Arg Asp Ala Gly Ile Val Gly Val Leu Thr Leu Asp Asn 4565 4570 4575 Gln Asp Leu Asn Gly Asn Trp Tyr Asp Phe Gly Asp Phe Val Gln 4580 4585 4590 Val Ala Pro Gly Cys Gly Val Pro Ile Val Asp Ser Tyr Tyr Ser 4595 4600 4605 Leu Leu Met Pro Ile Leu Thr Leu Thr Arg Ala Leu Ala Ala Glu 4610 4615 4620 Ser His Met Asp Ala Asp Leu Ala Lys Pro Leu Ile Lys Trp Asp 4625 4630 4635 Leu Leu Lys Tyr Asp Phe Thr Glu Glu Arg Leu Cys Leu Phe Asp 4640 4645 4650 Arg Tyr Phe Lys Tyr Trp Asp Gln Thr Tyr His Pro Asn Cys Ile 4655 4660 4665 Asn Cys Leu Asp Asp Arg Cys Ile Leu His Cys Ala Asn Phe Asn 4670 4675 4680 Val Leu Phe Ser Thr Val Phe Pro Pro Thr Ser Phe Gly Pro Leu 4685 4690 4695 Val Arg Lys Ile Phe Val Asp Gly Val Pro Phe Val Val Ser Thr 4700 4705 4710 Gly Tyr His Phe Arg Glu Leu Gly Val Val His Asn Gln Asp Val 4715 4720 4725 Asn Leu His Ser Ser Arg Leu Ser Phe Lys Glu Leu Leu Val Tyr 4730 4735 4740 Ala Ala Asp Pro Ala Met His Ala Ala Ser Gly Asn Leu Leu Leu 4745 4750 4755 Asp Lys Arg Thr Thr Cys Phe Ser Val Ala Ala Leu Thr Asn Asn 4760 4765 4770 Val Ala Phe Gln Thr Val Lys Pro Gly Asn Phe Asn Lys Asp Phe 4775 4780 4785 Tyr Asp Phe Ala Val Ser Lys Gly Phe Phe Lys Glu Gly Ser Ser 4790 4795 4800 Val Glu Leu Lys His Phe Phe Phe Ala Gln Asp Gly Asn Ala Ala 4805 4810 4815 Ile Ser Asp Tyr Asp Tyr Tyr Arg Tyr Asn Leu Pro Thr Met Cys 4820 4825 4830 Asp Ile Arg Gln Leu Leu Phe Val Val Glu Val Val Asp Lys Tyr 4835 4840 4845 Phe Asp Cys Tyr Asp Gly Gly Cys Ile Asn Ala Asn Gln Val Ile 4850 4855 4860 Val Asn Asn Leu Asp Lys Ser Ala Gly Phe Pro Phe Asn Lys Trp 4865 4870 4875 Gly Lys Ala Arg Leu Tyr Tyr Asp Ser Met Ser Tyr Glu Asp Gln 4880 4885 4890 Asp Ala Leu Phe Ala Tyr Thr Lys Arg Asn Val Ile Pro Thr Ile 4895 4900 4905 Thr Gln Met Asn Leu Lys Tyr Ala Ile Ser Ala Lys Asn Arg Ala 4910 4915 4920 Arg Thr Val Ala Gly Val Ser Ile Cys Ser Thr Met Thr Asn Arg 4925 4930 4935 Gln Phe His Gln Lys Leu Leu Lys Ser Ile Ala Ala Thr Arg Gly 4940 4945 4950 Ala Thr Val Val Ile Gly Thr Ser Lys Phe Tyr Gly Gly Trp His 4955 4960 4965 Asn Met Leu Lys Thr Val Tyr Ser Asp Val Glu Thr Pro His Leu 4970 4975 4980 Met Gly Trp Asp Tyr Pro Lys Cys Asp Arg Ala Met Pro Asn Met 4985 4990 4995 Leu Arg Ile Met Ala Ser Leu Val Leu Ala Arg Lys His Asn Thr 5000 5005 5010 Cys Cys Asn Leu Ser His Arg Phe Tyr Arg Leu Ala Asn Glu Cys 5015 5020 5025 Ala Gln Val Leu Ser Glu Met Val Met Cys Gly Gly Ser Leu Tyr 5030 5035 5040 Val Lys Pro Gly Gly Thr Ser Ser Gly Asp Ala Thr Thr Ala Tyr 5045 5050 5055 Ala Asn Ser Val Phe Asn Ile Cys Gln Ala Val Thr Ala Asn Val 5060 5065 5070 Asn Ala Leu Leu Ser Thr Asp Gly Asn Lys Ile Ala Asp Lys Tyr 5075 5080 5085 Val Arg Asn Leu Gln His Arg Leu Tyr Glu Cys Leu Tyr Arg Asn 5090 5095 5100 Arg Asp Val Asp His Glu Phe Val Asp Glu Phe Tyr Ala Tyr Leu 5105 5110 5115 Arg Lys His Phe Ser Met Met Ile Leu Ser Asp Asp Ala Val Val 5120 5125 5130 Cys Tyr Asn Ser Asn Tyr Ala Ala Gln Gly Leu Val Ala Ser Ile 5135 5140 5145 Lys Asn Phe Lys Ala Val Leu Tyr Tyr Gln Asn Asn Val Phe Met 5150 5155 5160 Ser Glu Ala Lys Cys Trp Thr Glu Thr Asp Leu Thr Lys Gly Pro 5165 5170 5175 His Glu Phe Cys Ser Gln His Thr Met Leu Val Lys Gln Gly Asp 5180 5185 5190 Asp Tyr Val Tyr Leu Pro Tyr Pro Asp Pro Ser Arg Ile Leu Gly 5195 5200 5205 Ala Gly Cys Phe Val Asp Asp Ile Val Lys Thr Asp Gly Thr Leu 5210 5215 5220 Met Ile Glu Arg Phe Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu 5225 5230 5235 Thr Lys His Pro Asn Gln Glu Tyr Ala Asp Val Phe His Leu Tyr 5240 5245 5250 Leu Gln Tyr Ile Arg Lys Leu His Asp Glu Leu Thr Gly His Met 5255 5260 5265 Leu Asp Met Tyr Ser Val Met Leu Thr Asn Asp Asn Thr Ser Arg 5270 5275 5280 Tyr Trp Glu Pro Glu Phe Tyr Glu Ala Met Tyr Thr Pro His Thr 5285 5290 5295 Val Leu Gln Ala Val Gly Ala Cys Val Leu Cys Asn Ser Gln Thr 5300 5305 5310 Ser Leu Arg Cys Gly Ala Cys Ile Arg Arg Pro Phe Leu Cys Cys 5315 5320 5325 Lys Cys Cys Tyr Asp His Val Ile Ser Thr Ser His Lys Leu Val 5330 5335 5340 Leu Ser Val Asn Pro Tyr Val Cys Asn Ala Pro Gly Cys Asp Val 5345 5350 5355 Thr Asp Val Thr Gln Leu Tyr Leu Gly Gly Met Ser Tyr Tyr Cys 5360 5365 5370 Lys Ser His Lys Pro Pro Ile Ser Phe Pro Leu Cys Ala Asn Gly 5375 5380 5385 Gln Val Phe Gly Leu Tyr Lys Asn Thr Cys Val Gly Ser Asp Asn 5390 5395 5400 Val Thr Asp Phe Asn Ala Ile Ala Thr Cys Asp Trp Thr Asn Ala 5405 5410 5415 Gly Asp Tyr Ile Leu Ala Asn Thr Cys Thr Glu Arg Leu Lys Leu 5420 5425 5430 Phe Ala Ala Glu Thr Leu Lys Ala Thr Glu Glu Thr Phe Lys Leu 5435 5440 5445 Ser Tyr Gly Ile Ala Thr Val Arg Glu Val Leu Ser Asp Arg Glu 5450 5455 5460 Leu His Leu Ser Trp Glu Val Gly Lys Pro Arg Pro Pro Leu Asn 5465 5470 5475 Arg Asn Tyr Val Phe Thr Gly Tyr Arg Val Thr Lys Asn Ser Lys 5480 5485 5490 Val Gln Ile Gly Glu Tyr Thr Phe Glu Lys Gly Asp Tyr Gly Asp 5495 5500 5505 Ala Val Val Tyr Arg Gly Thr Thr Thr Tyr Lys Leu Asn Val Gly 5510 5515 5520 Asp Tyr Phe Val Leu Thr Ser His Thr Val Met Pro Leu Ser Ala 5525 5530 5535 Pro Thr Leu Val Pro Gln Glu His Tyr Val Arg Ile Thr Gly Leu 5540 5545 5550 Tyr Pro Thr Leu Asn Ile Ser Asp Glu Phe Ser Ser Asn Val Ala 5555 5560 5565 Asn Tyr Gln Lys Val Gly Met Gln Lys Tyr Ser Thr Leu Gln Gly 5570 5575 5580 Pro Pro Gly Thr Gly Lys Ser His Phe Ala Ile Gly Leu Ala Leu 5585 5590 5595 Tyr Tyr Pro Ser Ala Arg Ile Val Tyr Thr Ala Cys Ser His Ala 5600 5605 5610 Ala Val Asp Ala Leu Cys Glu Lys Ala Leu Lys Tyr Leu Pro Ile 5615 5620 5625 Asp Lys Cys Ser Arg Ile Ile Pro Ala Arg Ala Arg Val Glu Cys 5630 5635 5640 Phe Asp Lys Phe Lys Val Asn Ser Thr Leu Glu Gln Tyr Val Phe 5645 5650 5655 Cys Thr Val Asn Ala Leu Pro Glu Thr Thr Ala Asp Ile Val Val 5660 5665 5670 Phe Asp Glu Ile Ser Met Ala Thr Asn Tyr Asp Leu Ser Val Val 5675 5680 5685 Asn Ala Arg Leu Arg Ala Lys His Tyr Val Tyr Ile Gly Asp Pro 5690 5695 5700 Ala Gln Leu Pro Ala Pro Arg Thr Leu Leu Thr Lys Gly Thr Leu 5705 5710 5715 Glu Pro Glu Tyr Phe Asn Ser Val Cys Arg Leu Met Lys Thr Ile 5720 5725 5730 Gly Pro Asp Met Phe Leu Gly Thr Cys Arg Arg Cys Pro Ala Glu 5735 5740 5745 Ile Val Asp Thr Val Ser Ala Leu Val Tyr Asp Asn Lys Leu Lys 5750 5755 5760 Ala His Lys Asp Lys Ser Ala Gln Cys Phe Lys Met Phe Tyr Lys 5765 5770 5775 Gly Val Ile Thr His Asp Val Ser Ser Ala Ile Asn Arg Pro Gln 5780 5785 5790 Ile Gly Val Val Arg Glu Phe Leu Thr Arg Asn Pro Ala Trp Arg 5795 5800 5805 Lys Ala Val Phe Ile Ser Pro Tyr Asn Ser Gln Asn Ala Val Ala 5810 5815 5820 Ser Lys Ile Leu Gly Leu Pro Thr Gln Thr Val Asp Ser Ser Gln 5825 5830 5835 Gly Ser Glu Tyr Asp Tyr Val Ile Phe Thr Gln Thr Thr Glu Thr 5840 5845 5850 Ala His Ser Cys Asn Val Asn Arg Phe Asn Val Ala Ile Thr Arg 5855 5860 5865 Ala Lys Ile Gly Ile Leu Cys Ile Met Ser Asp Arg Asp Leu Tyr 5870 5875 5880 Asp Lys Leu Gln Phe Thr Ser Leu Glu Ile Pro Arg Arg Asn Val 5885 5890 5895 Ala Thr Leu Gln Ala Glu Asn Val Thr Gly Leu Phe Lys Asp Cys 5900 5905 5910 Ser Lys Ile Ile Thr Gly Leu His Pro Thr Gln Ala Pro Thr His 5915 5920 5925 Leu Ser Val Asp Ile Lys Phe Lys Thr Glu Gly Leu Cys Val Asp 5930 5935 5940 Ile Pro Gly Ile Pro Lys Asp Met Thr Tyr Arg Arg Leu Ile Ser 5945 5950 5955 Met Met Gly Phe Lys Met Asn Tyr Gln Val Asn Gly Tyr Pro Asn 5960 5965 5970 Met Phe Ile Thr Arg Glu Glu Ala Ile Arg His Val Arg Ala Trp 5975 5980 5985 Ile Gly Phe Asp Val Glu Gly Cys His Ala Thr Arg Asp Ala Val 5990 5995 6000 Gly Thr Asn Leu Pro Leu Gln Leu Gly Phe Ser Thr Gly Val Asn 6005 6010 6015 Leu Val Ala Val Pro Thr Gly Tyr Val Asp Thr Glu Asn Asn Thr 6020 6025 6030 Glu Phe Thr Arg Val Asn Ala Lys Pro Pro Pro Gly Asp Gln Phe 6035 6040 6045 Lys His Leu Ile Pro Leu Met Tyr Lys Gly Leu Pro Trp Asn Val 6050 6055 6060 Val Arg Ile Lys Ile Val Gln Met Leu Ser Asp Thr Leu Lys Gly 6065 6070 6075 Leu Ser Asp Arg Val Val Phe Val Leu Trp Ala His Gly Phe Glu 6080 6085 6090 Leu Thr Ser Met Lys Tyr Phe Val Lys Ile Gly Pro Glu Arg Thr 6095 6100 6105 Cys Cys Leu Cys Asp Lys Arg Ala Thr Cys Phe Ser Thr Ser Ser 6110 6115 6120 Asp Thr Tyr Ala Cys Trp Asn His Ser Val Gly Phe Asp Tyr Val 6125 6130 6135 Tyr Asn Pro Phe Met Ile Asp Val Gln Gln Trp Gly Phe Thr Gly 6140 6145 6150 Asn Leu Gln Ser Asn His Asp Gln His Cys Gln Val His Gly Asn 6155 6160 6165 Ala His Val Ala Ser Cys Asp Ala Ile Met Thr Arg Cys Leu Ala 6170 6175 6180 Val His Glu Cys Phe Val Lys Arg Val Asp Trp Ser Val Glu Tyr 6185 6190 6195 Pro Ile Ile Gly Asp Glu Leu Arg Val Asn Ser Ala Cys Arg Lys 6200 6205 6210 Val Gln His Met Val Val Lys Ser Ala Leu Leu Ala Asp Lys Phe 6215 6220 6225 Pro Val Leu His Asp Ile Gly Asn Pro Lys Ala Ile Lys Cys Val 6230 6235 6240 Pro Gln Ala Glu Val Glu Trp Lys Phe Tyr Asp Ala Gln Pro Cys 6245 6250 6255 Ser Asp Lys Ala Tyr Lys Ile Glu Glu Leu Phe Tyr Ser Tyr Ala 6260 6265 6270 Thr His His Asp Lys Phe Thr Asp Gly Val Cys Leu Phe Trp Asn 6275 6280 6285 Cys Asn Val Asp Arg Tyr Pro Ala Asn Ala Ile Val Cys Arg Phe 6290 6295 6300 Asp Thr Arg Val Leu Ser Asn Leu Asn Leu Pro Gly Cys Asp Gly 6305 6310 6315 Gly Ser Leu Tyr Val Asn Lys His Ala Phe His Thr Pro Ala Phe 6320 6325 6330 Asp Lys Ser Ala Phe Thr Asn Leu Lys Gln Leu Pro Phe Phe Tyr 6335 6340 6345 Tyr Ser Asp Ser Pro Cys Glu Ser His Gly Lys Gln Val Val Ser 6350 6355 6360 Asp Ile Asp Tyr Val Pro Leu Lys Ser Ala Thr Cys Ile Thr Arg 6365 6370 6375 Cys Asn Leu Gly Gly Ala Val Cys Arg His His Ala Asn Glu Tyr 6380 6385 6390 Arg Gln Tyr Leu Asp Ala Tyr Asn Met Met Ile Ser Ala Gly Phe 6395 6400 6405 Ser Leu Trp Ile Tyr Lys Gln Phe Asp Thr Tyr Asn Leu Trp Asn 6410 6415 6420 Thr Phe Thr Arg Leu Gln Ser Leu Glu Asn Val Ala Tyr Asn Val 6425 6430 6435 Val Asn Lys Gly His Phe Asp Gly His Ala Gly Glu Ala Pro Val 6440 6445 6450 Ser Ile Ile Asn Asn Ala Val Tyr Thr Lys Val Asp Gly Ile Asp 6455 6460 6465 Val Glu Ile Phe Glu Asn Lys Thr Thr Leu Pro Val Asn Val Ala 6470 6475 6480 Phe Glu Leu Trp Ala Lys Arg Asn Ile Lys Pro Val Pro Glu Ile 6485 6490 6495 Lys Ile Leu Asn Asn Leu Gly Val Asp Ile Ala Ala Asn Thr Val 6500 6505 6510 Ile Trp Asp Tyr Lys Arg Glu Ala Pro Ala His Val Ser Thr Ile 6515 6520 6525 Gly Val Cys Thr Met Thr Asp Ile Ala Lys Lys Pro Thr Glu Ser 6530 6535 6540 Ala Cys Ser Ser Leu Thr Val Leu Phe Asp Gly Arg Val Glu Gly 6545 6550 6555 Gln Val Asp Leu Phe Arg Asn Ala Arg Asn Gly Val Leu Ile Thr 6560 6565 6570 Glu Gly Ser Val Lys Gly Leu Thr Pro Ser Lys Gly Pro Ala Gln 6575 6580 6585 Ala Ser Val Asn Gly Val Thr Leu Ile Gly Glu Ser Val Lys Thr 6590 6595 6600 Gln Phe Asn Tyr Phe Lys Lys Val Asp Gly Ile Ile Gln Gln Leu 6605 6610 6615 Pro Glu Thr Tyr Phe Thr Gln Ser Arg Asp Leu Glu Asp Phe Lys 6620 6625 6630 Pro Arg Ser Gln Met Glu Thr Asp Phe Leu Glu Leu Ala Met Asp 6635 6640 6645 Glu Phe Ile Gln Arg Tyr Lys Leu Glu Gly Tyr Ala Phe Glu His 6650 6655 6660 Ile Val Tyr Gly Asp Phe Ser His Gly Gln Leu Gly Gly Leu His 6665 6670 6675 Leu Met Ile Gly Leu Ala Lys Arg Ser Gln Asp Ser Pro Leu Lys 6680 6685 6690 Leu Glu Asp Phe Ile Pro Met Asp Ser Thr Val Lys Asn Tyr Phe 6695 6700 6705 Ile Thr Asp Ala Gln Thr Gly Ser Ser Lys Cys Val Cys Ser Val 6710 6715 6720 Ile Asp Leu Leu Leu Asp Asp Phe Val Glu Ile Ile Lys Ser Gln 6725 6730 6735 Asp Leu Ser Val Ile Ser Lys Val Val Lys Val Thr Ile Asp Tyr 6740 6745 6750 Ala Glu Ile Ser Phe Met Leu Trp Cys Lys Asp Gly His Val Glu 6755 6760 6765 Thr Phe Tyr Pro Lys Leu Gln Ala Ser Gln Ala Trp Gln Pro Gly 6770 6775 6780 Val Ala Met Pro Asn Leu Tyr Lys Met Gln Arg Met Leu Leu Glu 6785 6790 6795 Lys Cys Asp Leu Gln Asn Tyr Gly Glu Asn Ala Val Ile Pro Lys 6800 6805 6810 Gly Ile Met Met Asn Val Ala Lys Tyr Thr Gln Leu Cys Gln Tyr 6815 6820 6825 Leu Asn Thr Leu Thr Leu Ala Val Pro Tyr Asn Met Arg Val Ile 6830 6835 6840 His Phe Gly Ala Gly Ser Asp Lys Gly Val Ala Pro Gly Thr Ala 6845 6850 6855 Val Leu Arg Gln Trp Leu Pro Thr Gly Thr Leu Leu Val Asp Ser 6860 6865 6870 Asp Leu Asn Asp Phe Val Ser Asp Ala Asp Ser Thr Leu Ile Gly 6875 6880 6885 Asp Cys Ala Thr Val His Thr Ala Asn Lys Trp Asp Leu Ile Ile 6890 6895 6900 Ser Asp Met Tyr Asp Pro Arg Thr Lys His Val Thr Lys Glu Asn 6905 6910 6915 Asp Ser Lys Glu Gly Phe Phe Thr Tyr Leu Cys Gly Phe Ile Lys 6920 6925 6930 Gln Lys Leu Ala Leu Gly Gly Ser Ile Ala Val Lys Ile Thr Glu 6935 6940 6945 His Ser Trp Asn Ala Asp Leu Tyr Lys Leu Met Gly His Phe Ser 6950 6955 6960 Trp Trp Thr Ala Phe Val Thr Asn Val Asn Ala Ser Ser Ser Glu 6965 6970 6975 Ala Phe Leu Ile Gly Ala Asn Tyr Leu Gly Lys Pro Lys Glu Gln 6980 6985 6990 Ile Asp Gly Tyr Thr Met His Ala Asn Tyr Ile Phe Trp Arg Asn 6995 7000 7005 Thr Asn Pro Ile Gln Leu Ser Ser Tyr Ser Leu Phe Asp Met Ser 7010 7015 7020 Lys Phe Pro Leu Lys Leu Arg Gly Thr Ala Val Met Ser Leu Lys 7025 7030 7035 Glu Asn Gln Ile Asn Asp Met Ile Tyr Ser Leu Leu Glu Lys Gly 7040 7045 7050 Arg Leu Ile Ile Arg Glu Asn Asn Arg Val Val Val Ser Ser Asp 7055 7060 7065 Ile Leu Val Asn Asn 7070 <210> 28 <211> 6758 <212> PRT <213> human coronavirus 229E <220> <221> MISC_FEATURE <223> ORF 1 AB <400> 28 Met Ala Cys Asn Arg Val Thr Leu Ala Val Ala Ser Asp Ser Glu Ile 1 5 10 15 Ser Ala Asn Gly Cys Ser Thr Ile Ala Gln Ala Val Arg Arg Tyr Ser 20 25 30 Glu Ala Ala Ser Asn Gly Phe Arg Ala Cys Arg Phe Val Ser Leu Asp 35 40 45 Leu Gln Asp Cys Ile Val Gly Ile Ala Asp Asp Thr Tyr Val Met Gly 50 55 60 Leu His Gly Asn Gln Thr Leu Phe Cys Asn Ile Met Lys Phe Ser Asp 65 70 75 80 Arg Pro Phe Met Leu His Gly Trp Leu Val Phe Ser Asn Ser Asn Tyr 85 90 95 Leu Leu Glu Glu Phe Asp Val Val Phe Gly Lys Arg Gly Gly Gly Asn 100 105 110 Val Thr Tyr Thr Asp Gln Tyr Leu Cys Gly Ala Asp Gly Lys Pro Val 115 120 125 Met Ser Glu Asp Leu Trp Gln Phe Val Asp His Phe Gly Glu Asn Glu 130 135 140 Glu Ile Ile Ile Asn Gly His Thr Tyr Val Cys Ala Trp Leu Thr Lys 145 150 155 160 Arg Lys Pro Leu Asp Tyr Lys Arg Gln Asn Asn Leu Ala Ile Glu Glu 165 170 175 Ile Glu Tyr Val His Gly Asp Ala Leu His Thr Leu Arg Asn Gly Ser 180 185 190 Val Leu Glu Met Ala Lys Glu Val Lys Thr Ser Ser Lys Val Val Leu 195 200 205 Ser Asp Ala Leu Asp Lys Leu Tyr Lys Val Phe Gly Ser Pro Val Met 210 215 220 Thr Asn Gly Ser Asn Ile Leu Glu Ala Phe Thr Lys Pro Val Phe Ile 225 230 235 240 Ser Ala Leu Val Gln Cys Thr Cys Gly Thr Lys Ser Trp Ser Val Gly 245 250 255 Asp Trp Thr Gly Phe Lys Ser Ser Cys Cys Asn Val Ile Ser Asn Lys 260 265 270 Leu Cys Val Val Pro Gly Asn Val Lys Pro Gly Asp Ala Val Ile Thr 275 280 285 Thr Gln Gln Ala Gly Ala Gly Ile Lys Tyr Phe Cys Gly Met Thr Leu 290 295 300 Lys Phe Val Ala Asn Ile Glu Gly Val Ser Val Trp Arg Val Ile Ala 305 310 315 320 Leu Gln Ser Val Asp Cys Phe Val Ala Ser Ser Thr Phe Val Glu Glu 325 330 335 Glu His Val Asn Arg Met Asp Thr Phe Cys Phe Asn Val Arg Asn Ser 340 345 350 Val Thr Asp Glu Cys Arg Leu Ala Met Leu Gly Ala Glu Met Thr Ser 355 360 365 Asn Val Arg Arg Gln Val Ala Ser Gly Val Ile Asp Ile Ser Thr Gly 370 375 380 Trp Phe Asp Val Tyr Asp Asp Ile Phe Ala Glu Ser Lys Pro Trp Phe 385 390 395 400 Val Arg Lys Ala Glu Asp Ile Phe Gly Pro Cys Trp Ser Ala Leu Ala 405 410 415 Ser Ala Leu Lys Gln Leu Lys Val Thr Thr Gly Glu Leu Val Arg Phe 420 425 430 Val Lys Ser Ile Cys Asn Ser Ala Val Ala Val Val Gly Gly Thr Ile 435 440 445 Gln Ile Leu Ala Ser Val Pro Glu Lys Phe Leu Asn Ala Phe Asp Val 450 455 460 Phe Val Thr Ala Ile Gln Thr Val Phe Asp Cys Ala Val Glu Thr Cys 465 470 475 480 Thr Ile Ala Gly Lys Ala Phe Asp Lys Val Phe Asp Tyr Val Leu Leu 485 490 495 Asp Asn Ala Leu Val Lys Leu Val Thr Thr Lys Leu Lys Gly Val Arg 500 505 510 Glu Arg Gly Leu Asn Lys Val Lys Tyr Ala Thr Val Val Val Gly Ser 515 520 525 Thr Glu Glu Val Lys Ser Ser Arg Val Glu Arg Ser Thr Ala Val Leu 530 535 540 Thr Ile Ala Asn Asn Tyr Ser Lys Leu Phe Asp Glu Gly Tyr Thr Val 545 550 555 560 Val Ile Gly Asp Val Ala Tyr Phe Val Ser Asp Gly Tyr Phe Arg Leu 565 570 575 Met Ala Ser Pro Asn Ser Val Leu Thr Thr Ala Val Tyr Lys Pro Leu 580 585 590 Phe Ala Phe Asn Val Asn Val Met Gly Thr Arg Pro Glu Lys Phe Pro 595 600 605 Thr Thr Val Thr Cys Glu Asn Leu Glu Ser Ala Val Leu Phe Val Asn 610 615 620 Asp Lys Ile Thr Glu Phe Gln Leu Asp Tyr Ser Ile Asp Val Ile Asp 625 630 635 640 Asn Glu Ile Ile Val Lys Pro Asn Ile Ser Leu Cys Val Pro Leu Tyr 645 650 655 Val Arg Asp Tyr Val Asp Lys Trp Asp Asp Phe Cys Arg Gln Tyr Ser 660 665 670 Asn Glu Ser Trp Phe Glu Asp Asp Tyr Arg Ala Phe Ile Ser Val Leu 675 680 685 Asp Ile Thr Asp Ala Ala Val Lys Ala Ala Glu Ser Lys Ala Phe Val 690 695 700 Asp Thr Ile Val Pro Pro Cys Pro Ser Ile Leu Lys Val Ile Asp Gly 705 710 715 720 Gly Lys Ile Trp Asn Gly Val Ile Lys Asn Val Asn Ser Val Arg Asp 725 730 735 Trp Leu Lys Ser Leu Lys Leu Asn Leu Thr Gln Gln Gly Leu Leu Gly 740 745 750 Thr Cys Ala Lys Arg Phe Lys Arg Trp Leu Gly Ile Leu Leu Glu Ala 755 760 765 Tyr Asn Ala Phe Leu Asp Thr Val Val Ser Thr Val Lys Ile Gly Gly 770 775 780 Leu Thr Phe Lys Thr Tyr Ala Phe Asp Lys Pro Tyr Ile Val Ile Arg 785 790 795 800 Asp Ile Val Cys Lys Val Glu Asn Lys Thr Glu Ala Glu Trp Ile Glu 805 810 815 Leu Phe Pro His Asn Asp Arg Ile Lys Ser Phe Ser Thr Phe Glu Ser 820 825 830 Ala Tyr Met Pro Ile Ala Asp Pro Thr His Phe Asp Ile Glu Glu Val 835 840 845 Glu Leu Leu Asp Ala Glu Phe Val Glu Pro Gly Cys Gly Gly Ile Leu 850 855 860 Ala Val Ile Asp Glu His Val Phe Tyr Lys Lys Asp Gly Val Tyr Tyr 865 870 875 880 Pro Ser Asn Gly Thr Asn Ile Leu Pro Val Ala Phe Thr Lys Ala Ala 885 890 895 Gly Gly Lys Val Ser Phe Ser Asp Asp Val Glu Val Lys Asp Ile Glu 900 905 910 Pro Val Tyr Arg Val Lys Leu Cys Phe Glu Phe Glu Asp Glu Lys Leu 915 920 925 Val Asp Val Cys Glu Lys Ala Ile Gly Lys Lys Ile Lys His Glu Gly 930 935 940 Asp Trp Asp Ser Phe Cys Lys Thr Ile Gln Ser Ala Leu Ser Val Val 945 950 955 960 Ser Cys Tyr Val Asn Leu Pro Thr Tyr Tyr Ile Tyr Asp Glu Glu Gly 965 970 975 Gly Asn Asp Leu Ser Leu Pro Val Met Ile Ser Glu Trp Pro Leu Ser 980 985 990 Val Gln Gln Ala Gln Gln Glu Ala Thr Leu Pro Asp Ile Ala Glu Asp 995 1000 1005 Val Val Asp Gln Val Glu Glu Val Asn Ser Ile Phe Asp Ile Glu 1010 1015 1020 Thr Val Asp Val Lys His Asp Val Ser Pro Phe Glu Met Pro Phe 1025 1030 1035 Glu Glu Leu Asn Gly Leu Lys Ile Leu Lys Gln Leu Asp Asn Asn 1040 1045 1050 Cys Trp Val Asn Ser Val Met Leu Gln Ile Gln Leu Thr Gly Ile 1055 1060 1065 Leu Asp Gly Asp Tyr Ala Met Gln Phe Phe Lys Met Gly Arg Val 1070 1075 1080 Ala Lys Met Ile Glu Arg Cys Tyr Thr Ala Glu Gln Cys Ile Arg 1085 1090 1095 Gly Ala Met Gly Asp Val Gly Leu Cys Met Tyr Arg Leu Leu Lys 1100 1105 1110 Asp Leu His Thr Gly Phe Met Val Met Asp Tyr Lys Cys Ser Cys 1115 1120 1125 Thr Ser Gly Arg Leu Glu Glu Ser Gly Ala Val Leu Phe Cys Thr 1130 1135 1140 Pro Thr Lys Lys Ala Phe Pro Tyr Gly Thr Cys Leu Asn Cys Asn 1145 1150 1155 Ala Pro Arg Met Cys Thr Ile Arg Gln Leu Gln Gly Thr Ile Ile 1160 1165 1170 Phe Val Gln Gln Lys Pro Glu Pro Val Asn Pro Val Ser Phe Val 1175 1180 1185 Val Lys Pro Val Cys Ser Ser Ile Phe Arg Gly Ala Val Ser Cys 1190 1195 1200 Gly His Tyr Gln Thr Asn Ile Tyr Ser Gln Asn Leu Cys Val Asp 1205 1210 1215 Gly Phe Gly Val Asn Lys Ile Gln Pro Trp Thr Asn Asp Ala Leu 1220 1225 1230 Asn Thr Ile Cys Ile Lys Asp Ala Asp Tyr Asn Ala Lys Val Glu 1235 1240 1245 Ile Ser Val Thr Pro Ile Lys Asn Thr Val Asp Thr Thr Pro Lys 1250 1255 1260 Glu Glu Phe Val Val Lys Glu Lys Leu Asn Ala Phe Leu Val His 1265 1270 1275 Asp Asn Val Ala Phe Tyr Gln Gly Asp Val Asp Thr Val Val Asn 1280 1285 1290 Gly Val Asp Phe Asp Phe Ile Val Asn Ala Ala Asn Glu Asn Leu 1295 1300 1305 Ala His Gly Gly Gly Leu Ala Lys Ala Leu Asp Val Tyr Thr Lys 1310 1315 1320 Gly Lys Leu Gln Arg Leu Ser Lys Glu His Ile Gly Leu Ala Gly 1325 1330 1335 Lys Val Lys Val Gly Thr Gly Val Met Val Glu Cys Asp Ser Leu 1340 1345 1350 Arg Ile Phe Asn Val Val Gly Pro Arg Lys Gly Lys His Glu Arg 1355 1360 1365 Asp Leu Leu Ile Lys Ala Tyr Asn Thr Ile Asn Asn Glu Gln Gly 1370 1375 1380 Thr Pro Leu Thr Pro Ile Leu Ser Cys Gly Ile Phe Gly Ile Lys 1385 1390 1395 Leu Glu Thr Ser Leu Glu Val Leu Leu Asp Val Cys Asn Thr Lys 1400 1405 1410 Glu Val Lys Val Phe Val Tyr Thr Asp Thr Glu Val Cys Lys Val 1415 1420 1425 Lys Asp Phe Val Ser Gly Leu Val Asn Val Gln Lys Val Glu Gln 1430 1435 1440 Pro Lys Ile Glu Pro Lys Pro Val Ser Val Ile Lys Val Ala Pro 1445 1450 1455 Lys Pro Tyr Arg Val Asp Gly Lys Phe Ser Tyr Phe Thr Glu Asp 1460 1465 1470 Leu Leu Cys Val Ala Asp Asp Lys Pro Ile Val Leu Phe Thr Asp 1475 1480 1485 Ser Met Leu Thr Leu Asp Asp Arg Gly Leu Ala Leu Asp Asn Ala 1490 1495 1500 Leu Ser Gly Val Leu Ser Ala Ala Ile Lys Asp Cys Val Asp Ile 1505 1510 1515 Asn Lys Ala Ile Pro Ser Gly Asn Leu Ile Lys Phe Asp Ile Gly 1520 1525 1530 Ser Val Val Val Tyr Met Cys Val Val Pro Ser Glu Lys Asp Lys 1535 1540 1545 His Leu Asp Asn Asn Val Gln Arg Cys Thr Arg Lys Leu Asn Arg 1550 1555 1560 Leu Met Cys Asp Ile Val Cys Thr Ile Pro Ala Asp Tyr Ile Leu 1565 1570 1575 Pro Leu Val Leu Ser Ser Leu Thr Cys Asn Val Ser Phe Val Gly 1580 1585 1590 Glu Leu Lys Ala Ala Glu Ala Lys Val Ile Thr Ile Lys Val Thr 1595 1600 1605 Glu Asp Gly Val Asn Val His Asp Val Thr Val Thr Thr Asp Lys 1610 1615 1620 Ser Phe Glu Gln Gln Val Gly Val Ile Ala Asp Lys Asp Lys Asp 1625 1630 1635 Leu Ser Gly Ala Val Pro Ser Asp Leu Asn Thr Ser Glu Leu Leu 1640 1645 1650 Thr Lys Ala Ile Asp Val Asp Trp Val Glu Phe Tyr Gly Phe Lys 1655 1660 1665 Asp Ala Val Thr Phe Ala Thr Val Asp His Ser Ala Phe Ala Tyr 1670 1675 1680 Glu Ser Ala Val Val Asn Gly Ile Arg Val Leu Lys Thr Ser Asp 1685 1690 1695 Asn Asn Cys Trp Val Asn Ala Val Cys Ile Ala Leu Gln Tyr Ser 1700 1705 1710 Lys Pro His Phe Ile Ser Gln Gly Leu Asp Ala Ala Trp Asn Lys 1715 1720 1725 Phe Val Leu Gly Asp Val Glu Ile Phe Val Ala Phe Val Tyr Tyr 1730 1735 1740 Val Ala Arg Leu Met Lys Gly Asp Lys Gly Asp Ala Glu Asp Thr 1745 1750 1755 Leu Thr Lys Leu Ser Lys Tyr Leu Ala Asn Glu Ala Gln Val Gln 1760 1765 1770 Leu Glu His Tyr Ser Ser Cys Val Glu Cys Asp Ala Lys Phe Lys 1775 1780 1785 Asn Ser Val Ala Ser Ile Asn Ser Ala Ile Val Cys Ala Ser Val 1790 1795 1800 Lys Arg Asp Gly Val Gln Val Gly Tyr Cys Val His Gly Ile Lys 1805 1810 1815 Tyr Tyr Ser Arg Val Arg Ser Val Arg Gly Arg Ala Ile Ile Val 1820 1825 1830 Ser Val Glu Gln Leu Glu Pro Cys Ala Gln Ser Arg Leu Leu Ser 1835 1840 1845 Gly Val Ala Tyr Thr Ala Phe Ser Gly Pro Val Asp Lys Gly His 1850 1855 1860 Tyr Thr Val Tyr Asp Thr Ala Lys Lys Ser Met Tyr Asp Gly Asp 1865 1870 1875 Arg Phe Val Lys His Asp Leu Ser Leu Leu Ser Val Thr Ser Val 1880 1885 1890 Val Met Val Gly Gly Tyr Val Ala Pro Val Asn Thr Val Lys Pro 1895 1900 1905 Lys Pro Val Ile Asn Gln Leu Asp Glu Lys Ala Gln Lys Phe Phe 1910 1915 1920 Asp Phe Gly Asp Phe Leu Ile His Asn Phe Val Ile Phe Phe Thr 1925 1930 1935 Trp Leu Leu Ser Met Phe Thr Leu Cys Lys Thr Ala Val Thr Thr 1940 1945 1950 Gly Asp Val Lys Ile Met Ala Lys Ala Pro Gln Arg Thr Gly Val 1955 1960 1965 Val Leu Lys Arg Ser Leu Lys Tyr Asn Leu Lys Ala Ser Ala Ala 1970 1975 1980 Val Leu Lys Ser Lys Trp Trp Leu Leu Ala Lys Phe Thr Lys Leu 1985 1990 1995 Leu Leu Leu Ile Tyr Thr Leu Tyr Ser Val Val Leu Leu Cys Val 2000 2005 2010 Arg Phe Gly Pro Phe Asn Phe Cys Ser Glu Thr Val Asn Gly Tyr 2015 2020 2025 Ala Lys Ser Asn Phe Val Lys Asp Asp Tyr Cys Asp Gly Ser Leu 2030 2035 2040 Gly Cys Lys Met Cys Leu Phe Gly Tyr Gln Glu Leu Ser Gln Phe 2045 2050 2055 Ser His Leu Asp Val Val Trp Lys His Ile Thr Asp Pro Leu Phe 2060 2065 2070 Ser Asn Met Gln Pro Phe Ile Val Met Val Leu Leu Leu Ile Phe 2075 2080 2085 Gly Asp Asn Tyr Leu Arg Cys Phe Leu Leu Tyr Phe Val Ala Gln 2090 2095 2100 Met Ile Ser Thr Val Gly Val Phe Leu Gly Tyr Lys Glu Thr Asn 2105 2110 2115 Trp Phe Leu His Phe Ile Pro Phe Asp Val Ile Cys Asp Glu Leu 2120 2125 2130 Leu Val Thr Val Ile Val Ile Lys Val Ile Ser Phe Val Arg His 2135 2140 2145 Val Leu Phe Gly Cys Glu Asn Pro Asp Cys Ile Ala Cys Ser Lys 2150 2155 2160 Ser Ala Arg Leu Lys Arg Phe Pro Val Asn Thr Ile Val Asn Gly 2165 2170 2175 Val Gln Arg Ser Phe Tyr Val Asn Ala Asn Gly Gly Ser Lys Phe 2180 2185 2190 Cys Lys Lys His Arg Phe Phe Cys Val Asp Cys Asp Ser Tyr Gly 2195 2200 2205 Tyr Gly Ser Thr Phe Ile Thr Pro Glu Val Ser Arg Glu Leu Gly 2210 2215 2220 Asn Ile Thr Lys Thr Asn Val Gln Pro Thr Gly Pro Ala Tyr Val 2225 2230 2235 Met Ile Asp Lys Val Glu Phe Glu Asn Gly Phe Tyr Arg Leu Tyr 2240 2245 2250 Ser Cys Glu Thr Phe Trp Arg Tyr Asn Phe Asp Ile Thr Glu Ser 2255 2260 2265 Lys Tyr Ser Cys Lys Glu Val Phe Lys Asn Cys Asn Val Leu Asp 2270 2275 2280 Asp Phe Ile Val Phe Asn Asn Asn Gly Thr Asn Val Thr Gln Val 2285 2290 2295 Lys Asn Ala Ser Val Tyr Phe Ser Gln Leu Leu Cys Arg Pro Ile 2300 2305 2310 Lys Leu Val Asp Ser Glu Leu Leu Ser Thr Leu Ser Val Asp Phe 2315 2320 2325 Asn Gly Val Leu His Lys Ala Tyr Ile Asp Val Leu Arg Asn Ser 2330 2335 2340 Phe Gly Lys Asp Leu Asn Ala Asn Met Ser Leu Ala Glu Cys Lys 2345 2350 2355 Arg Ala Leu Gly Leu Ser Ile Ser Asp His Glu Phe Thr Ser Ala 2360 2365 2370 Ile Ser Asn Ala His Arg Cys Asp Val Leu Leu Ser Asp Leu Ser 2375 2380 2385 Phe Asn Asn Phe Val Ser Ser Tyr Ala Lys Pro Glu Glu Lys Leu 2390 2395 2400 Ser Ala Tyr Asp Leu Ala Cys Cys Met Arg Ala Gly Ala Lys Val 2405 2410 2415 Val Asn Ala Asn Val Leu Thr Lys Asp Gln Thr Pro Ile Val Trp 2420 2425 2430 His Ala Lys Asp Phe Asn Ser Leu Ser Ala Glu Gly Arg Lys Tyr 2435 2440 2445 Ile Val Lys Thr Ser Lys Ala Lys Gly Leu Thr Phe Leu Leu Thr 2450 2455 2460 Ile Asn Glu Asn Gln Ala Val Thr Gln Ile Pro Ala Thr Ser Ile 2465 2470 2475 Val Ala Lys Gln Gly Ala Gly Asp Ala Gly His Ser Leu Thr Trp 2480 2485 2490 Leu Trp Leu Leu Cys Gly Leu Val Cys Leu Ile Gln Phe Tyr Leu 2495 2500 2505 Cys Phe Phe Met Pro Tyr Phe Met Tyr Asp Ile Val Ser Ser Phe 2510 2515 2520 Glu Gly Tyr Asp Phe Lys Tyr Ile Glu Asn Gly Gln Leu Lys Asn 2525 2530 2535 Phe Glu Ala Pro Leu Lys Cys Val Arg Asn Val Phe Glu Asn Phe 2540 2545 2550 Glu Asp Trp His Tyr Ala Lys Phe Gly Phe Thr Pro Leu Asn Lys 2555 2560 2565 Gln Ser Cys Pro Ile Val Val Gly Val Ser Glu Ile Val Asn Thr 2570 2575 2580 Val Ala Gly Ile Pro Ser Asn Val Tyr Leu Val Gly Lys Thr Leu 2585 2590 2595 Ile Phe Thr Leu Gln Ala Ala Phe Gly Asn Ala Gly Val Cys Tyr 2600 2605 2610 Asp Ile Phe Gly Val Thr Thr Pro Glu Lys Cys Ile Phe Thr Ser 2615 2620 2625 Ala Cys Thr Arg Leu Glu Gly Leu Gly Gly Asn Asn Val Tyr Cys 2630 2635 2640 Tyr Asn Thr Ala Leu Met Glu Gly Ser Leu Pro Tyr Ser Ser Ile 2645 2650 2655 Gln Ala Asn Ala Tyr Tyr Lys Tyr Asp Asn Gly Asn Phe Ile Lys 2660 2665 2670 Leu Pro Glu Val Ile Ala Gln Gly Phe Gly Phe Arg Thr Val Arg 2675 2680 2685 Thr Ile Ala Thr Lys Tyr Cys Arg Val Gly Glu Cys Val Glu Ser 2690 2695 2700 Asn Ala Gly Val Cys Phe Gly Phe Asp Lys Trp Phe Val Asn Asp 2705 2710 2715 Gly Arg Val Ala Asn Gly Tyr Val Cys Gly Thr Gly Leu Trp Asn 2720 2725 2730 Leu Val Phe Asn Ile Leu Ser Met Phe Ser Ser Ser Phe Ser Val 2735 2740 2745 Ala Ala Met Ser Gly Gln Ile Leu Leu Asn Cys Ala Leu Gly Ala 2750 2755 2760 Phe Ala Ile Phe Cys Cys Phe Leu Val Thr Lys Phe Arg Arg Met 2765 2770 2775 Phe Gly Asp Leu Ser Val Gly Val Cys Thr Val Val Val Ala Val 2780 2785 2790 Leu Leu Asn Asn Val Ser Tyr Ile Val Thr Gln Asn Leu Val Thr 2795 2800 2805 Met Ile Ala Tyr Ala Ile Leu Tyr Phe Phe Ala Thr Arg Ser Leu 2810 2815 2820 Arg Tyr Ala Trp Ile Trp Cys Ala Ala Tyr Leu Ile Ala Tyr Ile 2825 2830 2835 Ser Phe Ala Pro Trp Trp Leu Cys Ala Trp Tyr Phe Leu Ala Met 2840 2845 2850 Leu Thr Gly Leu Leu Pro Ser Leu Leu Lys Leu Lys Val Ser Thr 2855 2860 2865 Asn Leu Phe Glu Gly Asp Lys Phe Val Gly Thr Phe Glu Ser Ala 2870 2875 2880 Ala Ala Gly Thr Phe Val Ile Asp Met Arg Ser Tyr Glu Lys Leu 2885 2890 2895 Ala Asn Ser Ile Ser Pro Glu Lys Leu Lys Ser Tyr Ala Ala Ser 2900 2905 2910 Tyr Asn Arg Tyr Lys Tyr Tyr Ser Gly Asn Ala Asn Glu Ala Asp 2915 2920 2925 Tyr Arg Cys Ala Cys Tyr Ala Tyr Leu Ala Lys Ala Met Leu Asp 2930 2935 2940 Phe Ser Arg Asp His Asn Asp Ile Leu Tyr Thr Pro Pro Thr Val 2945 2950 2955 Ser Tyr Gly Ser Thr Leu Gln Ala Gly Leu Arg Lys Met Ala Gln 2960 2965 2970 Pro Ser Gly Phe Val Glu Lys Cys Val Val Arg Val Cys Tyr Gly 2975 2980 2985 Asn Thr Val Leu Asn Gly Leu Trp Leu Gly Asp Ile Val Tyr Cys 2990 2995 3000 Pro Arg His Val Ile Ala Ser Asn Thr Thr Ser Ala Ile Asp Tyr 3005 3010 3015 Asp His Glu Tyr Ser Ile Met Arg Leu His Asn Phe Ser Ile Ile 3020 3025 3030 Ser Gly Thr Ala Phe Leu Gly Val Val Gly Ala Thr Met His Gly 3035 3040 3045 Val Thr Leu Lys Ile Lys Val Ser Gln Thr Asn Met His Thr Pro 3050 3055 3060 Arg His Ser Phe Arg Thr Leu Lys Ser Gly Glu Gly Phe Asn Ile 3065 3070 3075 Leu Ala Cys Tyr Asp Gly Cys Ala Gln Gly Val Phe Gly Val Asn 3080 3085 3090 Met Arg Thr Asn Trp Thr Ile Arg Gly Ser Phe Ile Asn Gly Ala 3095 3100 3105 Cys Gly Ser Pro Gly Tyr Asn Leu Lys Asn Gly Glu Val Glu Phe 3110 3115 3120 Val Tyr Met His Gln Ile Glu Leu Gly Ser Gly Ser His Val Gly 3125 3130 3135 Ser Ser Phe Asp Gly Val Met Tyr Gly Gly Phe Glu Asp Gln Pro 3140 3145 3150 Asn Leu Gln Val Glu Ser Ala Asn Gln Met Leu Thr Val Asn Val 3155 3160 3165 Val Ala Phe Leu Tyr Ala Ala Ile Leu Asn Gly Cys Thr Trp Trp 3170 3175 3180 Leu Lys Gly Glu Lys Leu Phe Val Glu His Tyr Asn Glu Trp Ala 3185 3190 3195 Gln Ala Asn Gly Phe Thr Ala Met Asn Gly Glu Asp Ala Phe Ser 3200 3205 3210 Ile Leu Ala Ala Lys Thr Gly Val Cys Val Glu Arg Leu Leu His 3215 3220 3225 Ala Ile Gln Val Leu Asn Asn Gly Phe Gly Gly Lys Gln Ile Leu 3230 3235 3240 Gly Tyr Ser Ser Leu Asn Asp Glu Phe Ser Ile Asn Glu Val Val 3245 3250 3255 Lys Gln Met Phe Gly Val Asn Leu Gln Ser Gly Lys Thr Thr Ser 3260 3265 3270 Met Phe Lys Ser Ile Ser Leu Phe Ala Gly Phe Phe Val Met Phe 3275 3280 3285 Trp Ala Glu Leu Phe Val Tyr Thr Thr Thr Ile Trp Val Asn Pro 3290 3295 3300 Gly Phe Leu Thr Pro Phe Met Ile Leu Leu Val Ala Leu Ser Leu 3305 3310 3315 Cys Leu Thr Phe Val Val Lys His Lys Val Leu Phe Leu Gln Val 3320 3325 3330 Phe Leu Leu Pro Ser Ile Ile Val Ala Ala Ile Gln Asn Cys Ala 3335 3340 3345 Trp Asp Tyr His Val Thr Lys Val Leu Ala Glu Lys Phe Asp Tyr 3350 3355 3360 Asn Val Ser Val Met Gln Met Asp Ile Gln Gly Phe Val Asn Ile 3365 3370 3375 Phe Ile Cys Leu Phe Val Ala Leu Leu His Thr Trp Arg Phe Ala 3380 3385 3390 Lys Glu Arg Cys Thr His Trp Cys Thr Tyr Leu Phe Ser Leu Ile 3395 3400 3405 Ala Val Leu Tyr Thr Ala Leu Tyr Ser Tyr Asp Tyr Val Ser Leu 3410 3415 3420 Leu Val Met Leu Leu Cys Ala Ile Ser Asn Glu Trp Tyr Ile Gly 3425 3430 3435 Ala Ile Ile Phe Arg Ile Cys Arg Phe Gly Val Ala Phe Leu Pro 3440 3445 3450 Val Glu Tyr Val Ser Tyr Phe Asp Gly Val Lys Thr Val Leu Leu 3455 3460 3465 Phe Tyr Met Leu Leu Gly Phe Val Ser Cys Met Tyr Tyr Gly Leu 3470 3475 3480 Leu Tyr Trp Ile Asn Arg Phe Cys Lys Cys Thr Leu Gly Val Tyr 3485 3490 3495 Asp Phe Cys Val Ser Pro Ala Glu Phe Lys Tyr Met Val Ala Asn 3500 3505 3510 Gly Leu Asn Ala Pro Asn Gly Pro Phe Asp Ala Leu Phe Leu Ser 3515 3520 3525 Phe Lys Leu Met Gly Ile Gly Gly Pro Arg Thr Ile Lys Val Ser 3530 3535 3540 Thr Val Gln Ser Lys Leu Thr Asp Leu Lys Cys Thr Asn Val Val 3545 3550 3555 Leu Met Gly Ile Leu Ser Asn Met Asn Ile Ala Ser Asn Ser Lys 3560 3565 3570 Glu Trp Ala Tyr Cys Val Glu Met His Asn Lys Ile Asn Leu Cys 3575 3580 3585 Asp Asp Pro Glu Thr Ala Gln Glu Leu Leu Leu Ala Leu Leu Ala 3590 3595 3600 Phe Phe Leu Ser Lys His Ser Asp Phe Gly Leu Gly Asp Leu Val 3605 3610 3615 Asp Ser Tyr Phe Glu Asn Asp Ser Ile Leu Gln Ser Val Ala Ser 3620 3625 3630 Ser Phe Val Gly Met Pro Ser Phe Val Ala Tyr Glu Thr Ala Arg 3635 3640 3645 Gln Glu Tyr Glu Asn Ala Val Ala Asn Gly Ser Ser Pro Gln Ile 3650 3655 3660 Ile Lys Gln Leu Lys Lys Ala Met Asn Val Ala Lys Ala Glu Phe 3665 3670 3675 Asp Arg Glu Ser Ser Val Gln Lys Lys Ile Asn Arg Met Ala Glu 3680 3685 3690 Gln Ala Ala Ala Ala Met Tyr Lys Glu Ala Arg Ala Val Asn Arg 3695 3700 3705 Lys Ser Lys Val Val Ser Ala Met His Ser Leu Leu Phe Gly Met 3710 3715 3720 Leu Arg Arg Leu Asp Met Ser Ser Val Asp Thr Ile Leu Asn Met 3725 3730 3735 Ala Arg Asn Gly Val Val Pro Leu Ser Val Ile Pro Ala Thr Ser 3740 3745 3750 Ala Ala Arg Leu Val Val Val Val Pro Asp His Asp Ser Phe Val 3755 3760 3765 Lys Met Met Val Asp Gly Phe Val His Tyr Ala Gly Val Val Trp 3770 3775 3780 Thr Leu Gln Glu Val Lys Asp Asn Asp Gly Lys Asn Val His Leu 3785 3790 3795 Lys Asp Val Thr Lys Glu Asn Gln Glu Ile Leu Val Trp Pro Leu 3800 3805 3810 Ile Leu Thr Cys Glu Arg Val Val Lys Leu Gln Asn Asn Glu Ile 3815 3820 3825 Met Pro Gly Lys Met Lys Val Lys Ala Thr Lys Gly Glu Gly Asp 3830 3835 3840 Gly Gly Ile Thr Ser Glu Gly Asn Ala Leu Tyr Asn Asn Glu Gly 3845 3850 3855 Gly Arg Ala Phe Met Tyr Ala Tyr Val Thr Thr Lys Pro Gly Met 3860 3865 3870 Lys Tyr Val Lys Trp Glu His Asp Ser Gly Val Val Thr Val Glu 3875 3880 3885 Leu Glu Pro Pro Cys Arg Phe Val Ile Asp Thr Pro Thr Gly Pro 3890 3895 3900 Gln Ile Lys Tyr Leu Tyr Phe Val Lys Asn Leu Asn Asn Leu Arg 3905 3910 3915 Arg Gly Ala Val Leu Gly Tyr Ile Gly Ala Thr Val Arg Leu Gln 3920 3925 3930 Ala Gly Lys Gln Thr Glu Phe Val Ser Asn Ser His Leu Leu Thr 3935 3940 3945 His Cys Ser Phe Ala Val Asp Pro Ala Ala Ala Tyr Leu Asp Ala 3950 3955 3960 Val Lys Gln Gly Ala Lys Pro Val Gly Asn Cys Val Lys Met Leu 3965 3970 3975 Thr Asn Gly Ser Gly Ser Gly Gln Ala Ile Thr Cys Thr Ile Asp 3980 3985 3990 Ser Asn Thr Thr Gln Asp Thr Tyr Gly Gly Ala Ser Val Cys Ile 3995 4000 4005 Tyr Cys Arg Ala His Val Ala His Pro Thr Met Asp Gly Phe Cys 4010 4015 4020 Gln Tyr Lys Gly Lys Trp Val Gln Val Pro Ile Gly Thr Asn Asp 4025 4030 4035 Pro Ile Arg Phe Cys Leu Glu Asn Thr Val Cys Lys Val Cys Gly 4040 4045 4050 Cys Trp Leu Asn His Gly Cys Thr Cys Asp Arg Thr Ala Ile Gln 4055 4060 4065 Ser Phe Asp Asn Ser Tyr Leu Asn Arg Val Arg Gly Ser Ser Ala 4070 4075 4080 Ala Arg Leu Glu Pro Cys Asn Gly Thr Asp Ile Asp Tyr Cys Val 4085 4090 4095 Arg Ala Phe Asp Val Tyr Asn Lys Asp Ala Ser Phe Ile Gly Lys 4100 4105 4110 Asn Leu Lys Ser Asn Cys Val Arg Phe Lys Asn Val Asp Lys Asp 4115 4120 4125 Asp Ala Phe Tyr Ile Val Lys Arg Cys Ile Lys Ser Val Met Asp 4130 4135 4140 His Glu Gln Ser Met Tyr Asn Leu Leu Lys Gly Cys Asn Ala Val 4145 4150 4155 Ala Lys His Asp Phe Phe Thr Trp His Glu Gly Arg Thr Ile Tyr 4160 4165 4170 Gly Asn Val Ser Arg Gln Asp Leu Thr Lys Tyr Thr Met Met Asp 4175 4180 4185 Leu Cys Phe Ala Leu Arg Asn Phe Asp Glu Lys Asp Cys Glu Val 4190 4195 4200 Phe Lys Glu Ile Leu Val Leu Thr Gly Cys Cys Ser Thr Asp Tyr 4205 4210 4215 Phe Glu Met Lys Asn Trp Phe Asp Pro Ile Glu Asn Glu Asp Ile 4220 4225 4230 His Arg Val Tyr Ala Ala Leu Gly Lys Val Val Ala Asn Ala Met 4235 4240 4245 Leu Lys Cys Val Ala Phe Cys Asp Glu Met Val Leu Lys Gly Val 4250 4255 4260 Val Gly Val Leu Thr Leu Asp Asn Gln Asp Leu Asn Gly Asn Phe 4265 4270 4275 Tyr Asp Phe Gly Asp Phe Val Leu Cys Pro Pro Gly Met Gly Ile 4280 4285 4290 Pro Tyr Cys Thr Ser Tyr Tyr Ser Tyr Met Met Pro Val Met Gly 4295 4300 4305 Met Thr Asn Cys Leu Ala Ser Glu Cys Phe Met Lys Ser Asp Ile 4310 4315 4320 Phe Gly Gln Asp Phe Lys Thr Phe Asp Leu Leu Lys Tyr Asp Phe 4325 4330 4335 Thr Glu His Lys Glu Val Leu Phe Asn Lys Tyr Phe Lys Tyr Trp 4340 4345 4350 Gly Gln Asp Tyr His Pro Asp Cys Val Asp Cys His Asp Glu Met 4355 4360 4365 Cys Ile Leu His Cys Ser Asn Phe Asn Thr Leu Phe Ala Thr Thr 4370 4375 4380 Ile Pro Asn Thr Ala Phe Gly Pro Leu Cys Arg Lys Val Phe Ile 4385 4390 4395 Asp Gly Val Pro Val Val Ala Thr Ala Gly Tyr His Phe Lys Gln 4400 4405 4410 Leu Gly Leu Val Trp Asn Lys Asp Val Asn Thr His Ser Thr Arg 4415 4420 4425 Leu Thr Ile Thr Glu Leu Leu Gln Phe Val Thr Asp Pro Thr Leu 4430 4435 4440 Ile Val Ala Ser Ser Pro Ala Leu Val Asp Lys Arg Thr Val Cys 4445 4450 4455 Phe Ser Val Ala Ala Leu Ser Thr Gly Leu Thr Ser Gln Thr Val 4460 4465 4470 Lys Pro Gly His Phe Asn Lys Glu Phe Tyr Asp Phe Leu Arg Ser 4475 4480 4485 Gln Gly Phe Phe Asp Glu Gly Ser Glu Leu Thr Leu Lys His Phe 4490 4495 4500 Phe Phe Thr Gln Lys Gly Asp Ala Ala Ile Lys Asp Phe Asp Tyr 4505 4510 4515 Tyr Arg Tyr Asn Arg Pro Thr Met Leu Asp Ile Gly Gln Ala Arg 4520 4525 4530 Val Ala Tyr Gln Val Ala Ala Arg Tyr Phe Asp Cys Tyr Glu Gly 4535 4540 4545 Gly Cys Ile Thr Ser Arg Glu Val Val Val Thr Asn Leu Asn Lys 4550 4555 4560 Ser Ala Gly Trp Pro Leu Asn Lys Phe Gly Lys Ala Gly Leu Tyr 4565 4570 4575 Tyr Glu Ser Ile Ser Tyr Glu Glu Gln Asp Ala Ile Phe Ser Leu 4580 4585 4590 Thr Lys Arg Asn Ile Leu Pro Thr Met Thr Gln Leu Asn Leu Lys 4595 4600 4605 Tyr Ala Ile Ser Gly Lys Glu Arg Ala Arg Thr Val Gly Gly Val 4610 4615 4620 Ser Leu Leu Ala Thr Met Thr Thr Arg Gln Phe His Gln Lys Cys 4625 4630 4635 Leu Lys Ser Ile Val Ala Thr Arg Asn Ala Thr Val Val Ile Gly 4640 4645 4650 Thr Thr Lys Phe Tyr Gly Gly Trp Asp Asn Met Leu Lys Asn Leu 4655 4660 4665 Met Ala Asp Val Asp Asp Pro Lys Leu Met Gly Trp Asp Tyr Pro 4670 4675 4680 Lys Cys Asp Arg Ala Met Pro Ser Met Ile Arg Met Leu Ser Ala 4685 4690 4695 Met Ile Leu Gly Ser Lys His Val Thr Cys Cys Thr Ala Ser Asp 4700 4705 4710 Lys Phe Tyr Arg Leu Ser Asn Glu Leu Ala Gln Val Leu Thr Glu 4715 4720 4725 Val Val Tyr Ser Asn Gly Gly Phe Tyr Phe Lys Pro Gly Gly Thr 4730 4735 4740 Thr Ser Gly Asp Ala Thr Thr Ala Tyr Ala Asn Ser Val Phe Asn 4745 4750 4755 Ile Phe Gln Ala Val Ser Ser Asn Ile Asn Cys Val Leu Ser Val 4760 4765 4770 Asn Ser Ser Asn Cys Asn Asn Phe Asn Val Lys Lys Leu Gln Arg 4775 4780 4785 Gln Leu Tyr Asp Asn Cys Tyr Arg Asn Ser Asn Val Asp Glu Ser 4790 4795 4800 Phe Val Asp Asp Phe Tyr Gly Tyr Leu Gln Lys His Phe Ser Met 4805 4810 4815 Met Ile Leu Ser Asp Asp Ser Val Val Cys Tyr Asn Lys Thr Tyr 4820 4825 4830 Ala Gly Leu Gly Tyr Ile Ala Asp Ile Ser Ala Phe Lys Ala Thr 4835 4840 4845 Leu Tyr Tyr Gln Asn Gly Val Phe Met Ser Thr Ala Lys Cys Trp 4850 4855 4860 Thr Glu Glu Asp Leu Ser Ile Gly Pro His Glu Phe Cys Ser Gln 4865 4870 4875 His Thr Met Gln Ile Val Asp Glu Asn Gly Lys Tyr Tyr Leu Pro 4880 4885 4890 Tyr Pro Asp Pro Ser Arg Ile Ile Ser Ala Gly Val Phe Val Asp 4895 4900 4905 Asp Ile Thr Lys Thr Asp Ala Val Ile Leu Leu Glu Arg Tyr Val 4910 4915 4920 Ser Leu Ala Ile Asp Ala Tyr Pro Leu Ser Lys His Pro Lys Pro 4925 4930 4935 Glu Tyr Arg Lys Val Phe Tyr Ala Leu Leu Asp Trp Val Lys His 4940 4945 4950 Leu Asn Lys Thr Leu Asn Glu Gly Val Leu Glu Ser Phe Ser Val 4955 4960 4965 Thr Leu Leu Asp Glu His Glu Ser Lys Phe Trp Asp Glu Ser Phe 4970 4975 4980 Tyr Ala Ser Met Tyr Glu Lys Ser Thr Val Leu Gln Ala Ala Gly 4985 4990 4995 Leu Cys Val Val Cys Gly Ser Gln Thr Val Leu Arg Cys Gly Asp 5000 5005 5010 Cys Leu Arg Arg Pro Met Leu Cys Thr Lys Cys Ala Tyr Asp His 5015 5020 5025 Val Phe Gly Thr Asp His Lys Phe Ile Leu Ala Ile Thr Pro Tyr 5030 5035 5040 Val Cys Asn Thr Ser Gly Cys Asn Val Asn Asp Val Thr Lys Leu 5045 5050 5055 Tyr Leu Gly Gly Leu Asn Tyr Tyr Cys Val Asp His Lys Pro His 5060 5065 5070 Leu Ser Phe Pro Leu Cys Ser Ala Gly Asn Val Phe Gly Leu Tyr 5075 5080 5085 Lys Ser Ser Ala Leu Gly Ser Met Asp Ile Asp Val Phe Asn Lys 5090 5095 5100 Leu Ser Thr Ser Asp Trp Ser Asp Ile Arg Asp Tyr Lys Leu Ala 5105 5110 5115 Asn Asp Ala Lys Glu Ser Leu Arg Leu Phe Ala Ala Glu Thr Val 5120 5125 5130 Lys Ala Lys Glu Glu Ser Val Lys Ser Ser Tyr Ala Tyr Ala Thr 5135 5140 5145 Leu Lys Glu Ile Val Gly Pro Lys Glu Leu Leu Leu Leu Trp Glu 5150 5155 5160 Ser Gly Lys Ala Lys Pro Pro Leu Asn Arg Asn Ser Val Phe Thr 5165 5170 5175 Cys Phe Gln Ile Thr Lys Asp Ser Lys Phe Gln Val Gly Glu Phe 5180 5185 5190 Val Phe Glu Lys Val Asp Tyr Gly Ser Asp Thr Val Thr Tyr Lys 5195 5200 5205 Ser Thr Ala Thr Thr Lys Leu Val Pro Gly Met Leu Phe Ile Leu 5210 5215 5220 Thr Ser His Asn Val Ala Pro Leu Arg Ala Pro Thr Met Ala Asn 5225 5230 5235 Gln Glu Lys Tyr Ser Thr Ile Tyr Lys Leu His Pro Ser Phe Asn 5240 5245 5250 Val Ser Asp Ala Tyr Ala Asn Leu Val Pro Tyr Tyr Gln Leu Ile 5255 5260 5265 Gly Lys Gln Arg Ile Thr Thr Ile Gln Gly Pro Pro Gly Ser Gly 5270 5275 5280 Lys Ser His Cys Ser Ile Gly Ile Gly Val Tyr Tyr Pro Gly Ala 5285 5290 5295 Arg Ile Val Phe Thr Ala Cys Ser His Ala Ala Val Asp Ser Leu 5300 5305 5310 Cys Ala Lys Ala Val Thr Ala Tyr Ser Val Asp Lys Cys Thr Arg 5315 5320 5325 Ile Ile Pro Ala Arg Ala Arg Val Glu Cys Tyr Ser Gly Phe Lys 5330 5335 5340 Pro Asn Asn Asn Ser Ala Gln Tyr Val Phe Ser Thr Val Asn Ala 5345 5350 5355 Leu Pro Glu Val Asn Ala Asp Ile Val Val Val Asp Glu Val Ser 5360 5365 5370 Met Cys Thr Asn Tyr Asp Leu Ser Val Ile Asn Gln Arg Ile Ser 5375 5380 5385 Tyr Lys His Ile Val Tyr Val Gly Asp Pro Gln Gln Leu Pro Ala 5390 5395 5400 Pro Arg Val Leu Ile Ser Lys Gly Val Met Glu Pro Ile Asp Tyr 5405 5410 5415 Asn Val Val Thr Gln Arg Met Cys Ala Ile Gly Pro Asp Val Phe 5420 5425 5430 Leu His Lys Cys Tyr Arg Cys Pro Ala Glu Ile Val Asn Thr Val 5435 5440 5445 Ser Glu Leu Val Tyr Glu Asn Lys Phe Val Pro Val Lys Glu Ala 5450 5455 5460 Ser Lys Gln Cys Phe Lys Ile Phe Glu Arg Gly Ser Val Gln Val 5465 5470 5475 Asp Asn Gly Ser Ser Ile Asn Arg Arg Gln Leu Asp Val Val Lys 5480 5485 5490 Arg Phe Ile His Lys Asn Ser Thr Trp Ser Lys Ala Val Phe Ile 5495 5500 5505 Ser Pro Tyr Asn Ser Gln Asn Tyr Val Ala Ala Arg Leu Leu Gly 5510 5515 5520 Leu Gln Thr Gln Thr Val Asp Ser Ala Gln Gly Ser Glu Tyr Asp 5525 5530 5535 Tyr Val Ile Phe Ala Gln Thr Ser Asp Thr Ala His Ala Cys Asn 5540 5545 5550 Ala Asn Arg Phe Asn Val Ala Ile Thr Arg Ala Lys Lys Gly Ile 5555 5560 5565 Phe Cys Ile Met Ser Asp Arg Thr Leu Phe Asp Ala Leu Lys Phe 5570 5575 5580 Phe Glu Ile Thr Met Thr Asp Leu Gln Ser Glu Ser Ser Cys Gly 5585 5590 5595 Leu Phe Lys Asp Cys Ala Arg Asn Pro Ile Asp Leu Pro Pro Ser 5600 5605 5610 His Ala Thr Thr Tyr Leu Ser Leu Ser Asp Arg Phe Lys Thr Ser 5615 5620 5625 Gly Asp Leu Ala Val Gln Ile Gly Asn Asn Asn Val Cys Thr Tyr 5630 5635 5640 Glu His Val Ile Ser Tyr Met Gly Phe Arg Phe Asp Val Ser Met 5645 5650 5655 Pro Gly Ser His Ser Leu Phe Cys Thr Arg Asp Phe Ala Met Arg 5660 5665 5670 His Val Arg Gly Trp Leu Gly Met Asp Val Glu Gly Ala His Val 5675 5680 5685 Thr Gly Asp Asn Val Gly Thr Asn Val Pro Leu Gln Val Gly Phe 5690 5695 5700 Ser Asn Gly Val Asp Phe Val Ala Gln Pro Glu Gly Cys Val Leu 5705 5710 5715 Thr Asn Thr Gly Ser Val Val Lys Pro Val Arg Ala Arg Ala Pro 5720 5725 5730 Pro Gly Glu Gln Phe Thr His Ile Val Pro Leu Leu Arg Lys Gly 5735 5740 5745 Gln Pro Trp Ser Val Leu Arg Lys Arg Ile Val Gln Met Ile Ala 5750 5755 5760 Asp Phe Leu Ala Gly Ser Ser Asp Val Leu Val Phe Val Leu Trp 5765 5770 5775 Ala Gly Gly Leu Glu Leu Thr Thr Met Arg Tyr Phe Val Lys Ile 5780 5785 5790 Gly Ala Val Lys His Cys Gln Cys Gly Thr Val Ala Thr Cys Tyr 5795 5800 5805 Asn Ser Val Ser Asn Asp Tyr Cys Cys Phe Lys His Ala Leu Gly 5810 5815 5820 Cys Asp Tyr Val Tyr Asn Pro Tyr Val Ile Asp Ile Gln Gln Trp 5825 5830 5835 Gly Tyr Val Gly Ser Leu Ser Thr Asn His His Ala Ile Cys Asn 5840 5845 5850 Val His Arg Asn Glu His Val Ala Ser Gly Asp Ala Ile Met Thr 5855 5860 5865 Arg Cys Leu Ala Val Tyr Asp Cys Phe Val Lys Asn Val Asp Trp 5870 5875 5880 Ser Ile Thr Tyr Pro Met Ile Ala Asn Glu Asn Ala Ile Asn Lys 5885 5890 5895 Gly Gly Arg Thr Val Gln Ser His Ile Met Arg Ala Ala Ile Lys 5900 5905 5910 Leu Tyr Asn Pro Lys Ala Ile His Asp Ile Gly Asn Pro Lys Gly 5915 5920 5925 Ile Arg Cys Ala Val Thr Asp Ala Lys Trp Tyr Cys Tyr Asp Lys 5930 5935 5940 Asn Pro Ile Asn Ser Asn Val Lys Thr Leu Glu Tyr Asp Tyr Met 5945 5950 5955 Thr His Gly Gln Met Asp Gly Leu Cys Leu Phe Trp Asn Cys Asn 5960 5965 5970 Val Asp Met Tyr Pro Glu Phe Ser Ile Val Cys Arg Phe Asp Thr 5975 5980 5985 Arg Thr Arg Ser Thr Leu Asn Leu Glu Gly Val Asn Gly Gly Ser 5990 5995 6000 Leu Tyr Val Asn Asn His Ala Phe His Thr Pro Ala Tyr Asp Lys 6005 6010 6015 Arg Ala Met Ala Lys Leu Lys Pro Ala Pro Phe Phe Tyr Tyr Asp 6020 6025 6030 Asp Gly Ser Cys Glu Val Val His Asp Gln Val Asn Tyr Val Pro 6035 6040 6045 Leu Arg Ala Thr Asn Cys Ile Thr Lys Cys Asn Ile Gly Gly Ala 6050 6055 6060 Val Cys Ser Lys His Ala Asn Leu Tyr Arg Ala Tyr Val Glu Ser 6065 6070 6075 Tyr Asn Ile Phe Thr Gln Ala Gly Phe Asn Ile Trp Val Pro Thr 6080 6085 6090 Thr Phe Asp Cys Tyr Asn Leu Trp Gln Thr Phe Thr Glu Val Asn 6095 6100 6105 Leu Gln Gly Leu Glu Asn Ile Ala Phe Asn Val Val Asn Lys Gly 6110 6115 6120 Ser Phe Val Gly Ala Asp Gly Glu Leu Pro Val Ala Ile Ser Gly 6125 6130 6135 Asp Lys Val Phe Val Arg Asp Gly Asn Thr Asp Asn Leu Val Phe 6140 6145 6150 Val Asn Lys Thr Ser Leu Pro Thr Asn Ile Ala Phe Glu Leu Phe 6155 6160 6165 Ala Lys Arg Lys Val Gly Leu Thr Pro Pro Leu Ser Ile Leu Lys 6170 6175 6180 Asn Leu Gly Val Val Ala Thr Tyr Lys Phe Val Leu Trp Asp Tyr 6185 6190 6195 Glu Ala Glu Arg Pro Leu Thr Ser Phe Thr Lys Ser Val Cys Gly 6200 6205 6210 Tyr Thr Asp Phe Ala Glu Asp Val Cys Thr Cys Tyr Asp Asn Ser 6215 6220 6225 Ile Gln Gly Ser Tyr Glu Arg Phe Thr Leu Ser Thr Asn Ala Val 6230 6235 6240 Leu Phe Ser Ala Thr Ala Val Lys Thr Gly Gly Lys Ser Leu Pro 6245 6250 6255 Ala Ile Lys Leu Asn Phe Gly Met Leu Asn Gly Asn Ala Ile Ala 6260 6265 6270 Thr Val Lys Ser Glu Asp Gly Asn Ile Lys Asn Ile Asn Trp Phe 6275 6280 6285 Val Tyr Val Arg Lys Asp Gly Lys Pro Val Asp His Tyr Asp Gly 6290 6295 6300 Phe Tyr Thr Gln Gly Arg Asn Leu Gln Asp Phe Leu Pro Arg Ser 6305 6310 6315 Thr Met Glu Glu Asp Phe Leu Asn Met Asp Ile Gly Val Phe Ile 6320 6325 6330 Gln Lys Tyr Gly Leu Glu Asp Phe Asn Phe Glu His Val Val Tyr 6335 6340 6345 Gly Asp Val Ser Lys Thr Thr Leu Gly Gly Leu His Leu Leu Ile 6350 6355 6360 Ser Gln Val Arg Leu Ser Lys Met Gly Ile Leu Lys Ala Glu Glu 6365 6370 6375 Phe Val Ala Ala Ser Asp Ile Thr Leu Lys Cys Cys Thr Val Thr 6380 6385 6390 Tyr Leu Asn Asp Pro Ser Ser Lys Thr Val Cys Thr Tyr Met Asp 6395 6400 6405 Leu Leu Leu Asp Asp Phe Val Ser Val Leu Lys Ser Leu Asp Leu 6410 6415 6420 Thr Val Val Ser Lys Val His Glu Val Ile Ile Asp Asn Lys Pro 6425 6430 6435 Trp Arg Trp Met Leu Trp Cys Lys Asp Asn Ala Val Ala Thr Phe 6440 6445 6450 Tyr Pro Gln Leu Gln Ser Ala Glu Trp Lys Cys Gly Tyr Ser Met 6455 6460 6465 Pro Gly Ile Tyr Lys Thr Gln Arg Met Cys Leu Glu Pro Cys Asn 6470 6475 6480 Leu Tyr Asn Tyr Gly Ala Gly Leu Lys Leu Pro Ser Gly Ile Met 6485 6490 6495 Phe Asn Val Val Lys Tyr Thr Gln Leu Cys Gln Tyr Phe Asn Ser 6500 6505 6510 Thr Thr Leu Cys Val Pro His Asn Met Arg Val Leu His Leu Gly 6515 6520 6525 Ala Gly Ser Asp Tyr Gly Val Ala Pro Gly Thr Ala Val Leu Lys 6530 6535 6540 Arg Trp Leu Pro His Asp Ala Ile Val Val Asp Asn Asp Val Val 6545 6550 6555 Asp Tyr Val Ser Asp Ala Asp Phe Ser Val Thr Gly Asp Cys Ala 6560 6565 6570 Thr Val Tyr Leu Glu Asp Lys Phe Asp Leu Leu Ile Ser Asp Met 6575 6580 6585 Tyr Asp Gly Arg Thr Lys Ala Ile Asp Gly Glu Asn Val Ser Lys 6590 6595 6600 Glu Gly Phe Phe Thr Tyr Ile Asn Gly Phe Ile Cys Glu Lys Leu 6605 6610 6615 Ala Ile Gly Gly Ser Ile Ala Ile Lys Val Thr Glu Tyr Ser Trp 6620 6625 6630 Asn Lys Lys Leu Tyr Glu Leu Val Gln Arg Phe Ser Phe Trp Thr 6635 6640 6645 Met Phe Cys Thr Ser Val Asn Thr Ser Ser Ser Glu Ala Phe Val 6650 6655 6660 Val Gly Ile Asn Tyr Leu Gly Asp Phe Ala Gln Gly Pro Phe Ile 6665 6670 6675 Asp Gly Asn Ile Ile His Ala Asn Tyr Val Phe Trp Arg Asn Ser 6680 6685 6690 Thr Val Met Ser Leu Ser Tyr Asn Ser Val Leu Asp Leu Ser Lys 6695 6700 6705 Phe Asn Cys Lys His Lys Ala Thr Val Val Val Gln Leu Lys Asp 6710 6715 6720 Ser Asp Ile Asn Glu Met Val Leu Ser Leu Val Arg Ser Gly Lys 6725 6730 6735 Leu Leu Val Arg Gly Asn Gly Lys Cys Leu Ser Phe Ser Asn His 6740 6745 6750 Leu Val Ser Thr Lys 6755 <210> 29 <211> 2666 <212> PRT <213> transmissible gastroenteritus virus <220> <221> MISC_FEATURE <223> ORF 1B <400> 29 Glu Pro Cys Asn Gly Thr Asp Pro Asp His Val Ser Arg Ala Phe Asp 1 5 10 15 Ile Tyr Asn Lys Asp Val Ala Cys Ile Gly Lys Phe Leu Lys Thr Asn 20 25 30 Cys Ser Arg Phe Arg Asn Leu Asp Lys His Asp Ala Tyr Tyr Ile Val 35 40 45 Lys Arg Cys Thr Lys Thr Val Met Asp His Glu Gln Val Cys Tyr Asn 50 55 60 Asp Leu Lys Asp Ser Gly Ala Val Ala Glu His Asp Phe Phe Thr Tyr 65 70 75 80 Lys Glu Gly Arg Cys Glu Phe Gly Asn Val Ala Arg Arg Asn Leu Thr 85 90 95 Lys Tyr Thr Met Met Asp Leu Cys Tyr Ala Ile Arg Asn Phe Asp Glu 100 105 110 Lys Asn Cys Glu Val Leu Lys Glu Ile Leu Val Thr Val Gly Ala Cys 115 120 125 Thr Glu Glu Phe Phe Glu Asn Lys Asp Trp Phe Asp Pro Val Glu Asn 130 135 140 Glu Ala Ile His Glu Val Tyr Ala Lys Leu Gly Pro Ile Val Ala Asn 145 150 155 160 Ala Met Leu Lys Cys Val Ala Phe Cys Asp Ala Ile Val Glu Lys Gly 165 170 175 Tyr Ile Gly Val Ile Thr Leu Asp Asn Gln Asp Leu Asn Gly Asn Phe 180 185 190 Tyr Asp Phe Gly Asp Phe Val Lys Thr Ala Pro Gly Phe Gly Cys Ala 195 200 205 Cys Val Thr Ser Tyr Tyr Ser Tyr Met Met Pro Leu Met Gly Met Thr 210 215 220 Ser Cys Leu Glu Ser Glu Asn Phe Val Lys Ser Asp Ile Tyr Gly Ser 225 230 235 240 Asp Tyr Lys Gln Tyr Asp Leu Leu Ala Tyr Asp Phe Thr Glu His Lys 245 250 255 Glu Tyr Leu Phe Gln Lys Tyr Phe Lys Tyr Trp Asp Arg Thr Tyr His 260 265 270 Pro Asn Cys Ser Asp Cys Thr Ser Asp Glu Cys Ile Ile His Cys Ala 275 280 285 Asn Phe Asn Thr Leu Phe Ser Met Thr Ile Pro Met Thr Ala Phe Gly 290 295 300 Pro Leu Val Arg Lys Val His Ile Asp Gly Val Pro Val Val Val Thr 305 310 315 320 Ala Gly Tyr His Phe Lys Gln Leu Gly Ile Val Trp Asn Leu Asp Val 325 330 335 Lys Leu Asp Thr Met Lys Leu Ser Met Thr Asp Leu Leu Arg Phe Val 340 345 350 Thr Asp Pro Thr Leu Leu Val Ala Ser Ser Pro Ala Leu Leu Asp Gln 355 360 365 Arg Thr Val Cys Phe Ser Ile Ala Ala Leu Ser Thr Gly Ile Thr Tyr 370 375 380 Gln Thr Val Lys Pro Gly His Phe Asn Lys Asp Phe Tyr Asp Phe Ile 385 390 395 400 Thr Glu Arg Gly Phe Phe Glu Glu Gly Ser Glu Leu Thr Leu Lys His 405 410 415 Phe Phe Phe Ala Gln Gly Gly Glu Ala Ala Met Thr Asp Phe Asn Tyr 420 425 430 Tyr Arg Tyr Asn Arg Val Thr Val Leu Asp Ile Cys Gln Ala Gln Phe 435 440 445 Val Tyr Lys Ile Val Gly Lys Tyr Phe Glu Cys Tyr Asp Gly Gly Cys 450 455 460 Ile Asn Ala Arg Glu Val Val Val Thr Asn Tyr Asp Lys Ser Ala Gly 465 470 475 480 Tyr Pro Leu Asn Lys Phe Gly Lys Ala Arg Leu Tyr Tyr Glu Thr Leu 485 490 495 Ser Tyr Glu Glu Gln Asp Ala Leu Phe Ala Leu Thr Lys Arg Asn Val 500 505 510 Leu Pro Thr Met Thr Gln Met Asn Leu Lys Tyr Ala Ile Ser Gly Lys 515 520 525 Ala Arg Ala Arg Thr Val Gly Gly Val Ser Leu Leu Ser Thr Met Thr 530 535 540 Thr Arg Gln Tyr His Gln Lys His Leu Lys Ser Ile Ala Ala Thr Arg 545 550 555 560 Asn Ala Thr Val Val Ile Gly Ser Thr Lys Phe Tyr Gly Gly Trp Asp 565 570 575 Asn Met Leu Lys Asn Leu Met Arg Asp Val Asp Asn Gly Cys Leu Met 580 585 590 Gly Trp Asp Tyr Pro Lys Cys Asp Arg Ala Leu Pro Asn Met Ile Arg 595 600 605 Met Ala Ser Ala Met Ile Leu Gly Ser Lys His Val Gly Cys Cys Thr 610 615 620 His Asn Asp Arg Phe Tyr Arg Leu Ser Asn Glu Leu Ala Gln Val Leu 625 630 635 640 Thr Glu Val Val His Cys Thr Gly Gly Phe Tyr Phe Lys Pro Gly Gly 645 650 655 Thr Thr Ser Gly Asp Gly Thr Thr Ala Tyr Ala Asn Ser Ala Phe Asn 660 665 670 Ile Phe Gln Ala Val Ser Ala Asn Val Asn Lys Leu Leu Gly Val Asp 675 680 685 Ser Asn Ala Cys Asn Asn Val Thr Val Lys Ser Ile Gln Arg Lys Ile 690 695 700 Tyr Asp Asn Cys Tyr Arg Ser Ser Ser Ile Asp Glu Glu Phe Val Val 705 710 715 720 Glu Tyr Phe Ser Tyr Leu Arg Lys His Phe Ser Met Met Ile Leu Ser 725 730 735 Asp Asp Gly Val Val Cys Tyr Asn Lys Asp Tyr Ala Asp Leu Gly Tyr 740 745 750 Val Ala Asp Ile Asn Ala Phe Lys Ala Thr Leu Tyr Tyr Gln Asn Asn 755 760 765 Val Phe Met Ser Thr Ser Lys Cys Trp Val Glu Pro Asp Leu Ser Val 770 775 780 Gly Pro His Glu Phe Cys Ser Gln His Thr Leu Gln Ile Val Gly Pro 785 790 795 800 Asp Gly Asp Tyr Tyr Leu Pro Tyr Pro Asp Pro Ser Arg Ile Leu Ser 805 810 815 Ala Gly Val Phe Val Asp Asp Ile Val Lys Thr Asp Asn Val Ile Met 820 825 830 Leu Glu Arg Tyr Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu Thr Lys 835 840 845 His Pro Lys Pro Ala Tyr Gln Lys Val Phe Tyr Thr Leu Leu Asp Trp 850 855 860 Val Lys His Leu Gln Lys Asn Leu Asn Ala Gly Val Leu Asp Ser Phe 865 870 875 880 Ser Val Thr Met Leu Glu Glu Gly Gln Asp Lys Phe Trp Ser Glu Glu 885 890 895 Phe Tyr Ala Ser Leu Tyr Glu Lys Ser Thr Val Leu Gln Ala Ala Gly 900 905 910 Met Cys Val Val Cys Gly Ser Gln Thr Val Leu Arg Cys Gly Asp Cys 915 920 925 Leu Arg Arg Pro Leu Leu Cys Thr Lys Cys Ala Tyr Asp His Val Met 930 935 940 Gly Thr Lys His Lys Phe Ile Met Ser Ile Thr Pro Tyr Val Cys Ser 945 950 955 960 Phe Asn Gly Cys Asn Val Asn Asp Val Thr Lys Leu Phe Leu Gly Gly 965 970 975 Leu Ser Tyr Tyr Cys Met Asn His Lys Pro Gln Leu Ser Phe Pro Leu 980 985 990 Cys Ala Asn Gly Asn Val Phe Gly Leu Tyr Lys Ser Ser Ala Val Gly 995 1000 1005 Ser Glu Ala Val Glu Asp Phe Asn Lys Leu Ala Val Ser Asp Trp 1010 1015 1020 Thr Asn Val Glu Asp Tyr Lys Leu Ala Asn Asn Val Lys Glu Ser 1025 1030 1035 Leu Lys Ile Phe Ala Ala Glu Thr Val Lys Ala Lys Glu Glu Ser 1040 1045 1050 Val Lys Ser Glu Tyr Ala Tyr Ala Val Leu Lys Glu Val Ile Gly 1055 1060 1065 Pro Lys Glu Ile Val Leu Gln Trp Glu Ala Ser Lys Thr Lys Pro 1070 1075 1080 Pro Leu Asn Arg Asn Ser Val Phe Thr Cys Phe Gln Ile Ser Lys 1085 1090 1095 Asp Thr Lys Ile Gln Leu Gly Glu Phe Val Phe Glu Gln Ser Glu 1100 1105 1110 Tyr Gly Ser Asp Ser Val Tyr Tyr Lys Ser Thr Ser Thr Tyr Lys 1115 1120 1125 Leu Thr Pro Gly Met Ile Phe Val Leu Thr Ser His Asn Val Ser 1130 1135 1140 Pro Leu Lys Ala Pro Ile Leu Val Asn Gln Glu Lys Tyr Asn Thr 1145 1150 1155 Ile Ser Lys Leu Tyr Pro Val Phe Asn Ile Ala Glu Ala Tyr Asn 1160 1165 1170 Thr Leu Val Pro Tyr Tyr Gln Met Ile Gly Lys Gln Lys Phe Thr 1175 1180 1185 Thr Ile Gln Gly Pro Pro Gly Ser Gly Lys Ser His Cys Val Ile 1190 1195 1200 Gly Leu Gly Leu Tyr Tyr Pro Gln Ala Arg Ile Val Tyr Thr Ala 1205 1210 1215 Cys Ser His Ala Ala Val Asp Ala Leu Cys Glu Lys Ala Ala Lys 1220 1225 1230 Asn Phe Asn Val Asp Arg Cys Ser Arg Ile Ile Pro Gln Arg Ile 1235 1240 1245 Arg Val Asp Cys Tyr Thr Gly Phe Lys Pro Asn Asn Thr Asn Ala 1250 1255 1260 Gln Tyr Leu Phe Cys Thr Val Asn Ala Leu Pro Glu Ala Ser Cys 1265 1270 1275 Asp Ile Val Val Val Asp Glu Val Ser Met Cys Thr Asn Tyr Asp 1280 1285 1290 Leu Ser Val Ile Asn Ser Arg Leu Ser Tyr Lys His Ile Val Tyr 1295 1300 1305 Val Gly Asp Pro Gln Gln Leu Pro Ala Pro Arg Thr Leu Ile Asn 1310 1315 1320 Lys Gly Val Leu Gln Pro Gln Asp Tyr Asn Val Val Thr Lys Arg 1325 1330 1335 Met Cys Thr Leu Gly Pro Asp Val Phe Leu His Lys Cys Tyr Arg 1340 1345 1350 Cys Pro Ala Glu Ile Val Lys Thr Val Ser Ala Leu Val Tyr Glu 1355 1360 1365 Asn Lys Phe Val Pro Val Asn Pro Glu Ser Lys Gln Cys Phe Lys 1370 1375 1380 Met Phe Val Lys Gly Gln Val Gln Ile Glu Ser Asn Ser Ser Ile 1385 1390 1395 Asn Asn Lys Gln Leu Glu Val Val Lys Ala Phe Leu Ala His Asn 1400 1405 1410 Pro Lys Trp Arg Lys Ala Val Phe Ile Ser Pro Tyr Asn Ser Gln 1415 1420 1425 Asn Tyr Val Ala Arg Arg Leu Leu Gly Leu Gln Thr Gln Thr Val 1430 1435 1440 Asp Ser Ala Gln Gly Ser Glu Tyr Asp Tyr Val Ile Tyr Thr Gln 1445 1450 1455 Thr Ser Asp Thr Gln His Ala Thr Asn Val Asn Arg Phe Asn Val 1460 1465 1470 Ala Ile Thr Arg Ala Lys Val Gly Ile Leu Cys Ile Met Cys Asp 1475 1480 1485 Arg Thr Met Tyr Glu Asn Leu Asp Phe Tyr Glu Leu Lys Asp Ser 1490 1495 1500 Lys Ile Gly Leu Gln Ala Lys Pro Glu Thr Cys Gly Leu Phe Lys 1505 1510 1515 Asp Cys Ser Lys Ser Glu Gln Tyr Ile Pro Pro Ala Tyr Ala Thr 1520 1525 1530 Thr Tyr Met Ser Leu Ser Asp Asn Phe Lys Thr Ser Asp Gly Leu 1535 1540 1545 Ala Val Asn Ile Gly Thr Lys Asp Val Lys Tyr Ala Asn Val Ile 1550 1555 1560 Ser Tyr Met Gly Phe Arg Phe Glu Ala Asn Ile Pro Gly Tyr His 1565 1570 1575 Thr Leu Phe Cys Thr Arg Asp Phe Ala Met Arg Asn Val Arg Ala 1580 1585 1590 Trp Leu Gly Phe Asp Val Glu Gly Ala His Val Cys Gly Asp Asn 1595 1600 1605 Val Gly Thr Asn Val Pro Leu Gln Leu Gly Phe Ser Asn Gly Val 1610 1615 1620 Asp Phe Val Val Gln Thr Glu Gly Cys Val Ile Thr Glu Lys Gly 1625 1630 1635 Asn Ser Ile Glu Val Val Lys Ala Arg Ala Pro Pro Gly Glu Gln 1640 1645 1650 Phe Ala His Leu Ile Pro Leu Met Arg Lys Gly Gln Pro Trp His 1655 1660 1665 Ile Val Arg Arg Arg Ile Val Gln Met Val Cys Asp Tyr Phe Asp 1670 1675 1680 Gly Leu Ser Asp Ile Leu Ile Phe Val Leu Trp Ala Gly Gly Leu 1685 1690 1695 Glu Leu Thr Thr Met Arg Tyr Phe Val Lys Ile Gly Arg Pro Gln 1700 1705 1710 Lys Cys Glu Cys Gly Lys Ser Ala Thr Cys Tyr Ser Ser Ser Gln 1715 1720 1725 Ser Val Tyr Ala Cys Phe Lys His Ala Leu Gly Cys Asp Tyr Leu 1730 1735 1740 Tyr Asn Pro Tyr Cys Ile Asp Ile Gln Gln Trp Gly Tyr Thr Gly 1745 1750 1755 Ser Leu Ser Met Asn His His Glu Val Cys Asn Ile His Arg Asn 1760 1765 1770 Glu His Val Ala Ser Gly Asp Ala Ile Met Thr Arg Cys Leu Ala 1775 1780 1785 Ile His Asp Cys Phe Val Lys Arg Val Asp Trp Ser Ile Val Tyr 1790 1795 1800 Pro Phe Ile Asp Asn Glu Glu Lys Ile Asn Lys Ala Gly Arg Ile 1805 1810 1815 Val Gln Ser His Val Met Lys Ala Ala Leu Lys Ile Phe Asn Pro 1820 1825 1830 Ala Ala Ile His Asp Val Gly Asn Pro Lys Gly Ile Arg Cys Ala 1835 1840 1845 Thr Thr Pro Ile Pro Trp Phe Cys Tyr Asp Arg Asp Pro Ile Asn 1850 1855 1860 Asn Asn Val Arg Cys Leu Asp Tyr Asp Tyr Met Val His Gly Gln 1865 1870 1875 Met Asn Gly Leu Met Leu Phe Trp Asn Cys Asn Val Asp Met Tyr 1880 1885 1890 Pro Glu Phe Ser Ile Val Cys Arg Phe Asp Thr Arg Thr Arg Ser 1895 1900 1905 Lys Leu Ser Leu Glu Gly Cys Asn Gly Gly Ala Leu Tyr Val Asn 1910 1915 1920 Asn His Ala Phe His Thr Pro Ala Tyr Asp Arg Arg Ala Phe Ala 1925 1930 1935 Lys Leu Lys Pro Met Pro Phe Phe Tyr Tyr Asp Asp Ser Asn Cys 1940 1945 1950 Glu Leu Val Asp Gly Gln Pro Asn Tyr Val Pro Leu Lys Ser Asn 1955 1960 1965 Val Cys Ile Thr Lys Cys Asn Ile Gly Gly Ala Val Cys Lys Lys 1970 1975 1980 His Ala Ala Leu Tyr Arg Ala Tyr Val Glu Asp Tyr Asn Ile Phe 1985 1990 1995 Met Gln Ala Gly Phe Thr Ile Trp Cys Pro Gln Asn Phe Asp Thr 2000 2005 2010 Tyr Met Leu Trp His Gly Phe Val Asn Ser Lys Ala Leu Gln Ser 2015 2020 2025 Leu Glu Asn Val Ala Phe Asn Val Val Lys Lys Gly Ala Phe Thr 2030 2035 2040 Gly Leu Lys Gly Asp Leu Pro Thr Ala Val Ile Ala Asp Lys Ile 2045 2050 2055 Met Val Arg Asp Gly Pro Thr Asp Lys Cys Ile Phe Thr Asn Lys 2060 2065 2070 Thr Ser Leu Pro Thr Asn Val Ala Phe Glu Leu Tyr Ala Lys Arg 2075 2080 2085 Lys Leu Gly Leu Thr Pro Pro Leu Thr Ile Leu Arg Asn Leu Gly 2090 2095 2100 Val Val Ala Thr Tyr Lys Phe Val Leu Trp Asp Tyr Glu Ala Glu 2105 2110 2115 Arg Pro Phe Ser Asn Phe Thr Lys Gln Val Cys Ser Tyr Thr Asp 2120 2125 2130 Leu Asp Ser Glu Val Val Thr Cys Phe Asp Asn Ser Ile Ala Gly 2135 2140 2145 Ser Phe Glu Arg Phe Thr Thr Thr Arg Asp Ala Val Leu Ile Ser 2150 2155 2160 Asn Asn Ala Val Lys Gly Leu Ser Ala Ile Lys Leu Gln Tyr Gly 2165 2170 2175 Leu Leu Asn Asp Leu Pro Val Ser Thr Val Gly Asn Lys Pro Val 2180 2185 2190 Thr Trp Tyr Ile Tyr Val Arg Lys Asn Gly Glu Tyr Val Glu Gln 2195 2200 2205 Ile Asp Ser Tyr Tyr Thr Gln Gly Arg Thr Phe Glu Thr Phe Lys 2210 2215 2220 Pro Arg Ser Thr Met Glu Glu Asp Phe Leu Ser Met Asp Thr Thr 2225 2230 2235 Leu Phe Ile Gln Lys Tyr Gly Leu Glu Asp Tyr Gly Phe Glu His 2240 2245 2250 Val Val Phe Gly Asp Val Ser Lys Thr Thr Ile Gly Gly Met His 2255 2260 2265 Leu Leu Ile Ser Gln Val Arg Leu Ala Lys Met Gly Leu Phe Ser 2270 2275 2280 Val Gln Glu Phe Met Asn Asn Ser Asp Ser Thr Leu Lys Ser Cys 2285 2290 2295 Cys Ile Thr Tyr Ala Asp Asp Pro Ser Ser Lys Asn Val Cys Thr 2300 2305 2310 Tyr Met Asp Ile Leu Leu Asp Asp Phe Val Thr Ile Ile Lys Ser 2315 2320 2325 Leu Asp Leu Asn Val Val Ser Lys Val Val Asp Val Ile Val Asp 2330 2335 2340 Cys Lys Ala Trp Arg Trp Met Leu Trp Cys Glu Asn Ser His Ile 2345 2350 2355 Lys Thr Phe Tyr Pro Gln Leu Gln Ser Ala Glu Trp Asn Pro Gly 2360 2365 2370 Tyr Ser Met Pro Thr Leu Tyr Lys Ile Gln Arg Met Cys Leu Glu 2375 2380 2385 Arg Cys Asn Leu Tyr Asn Tyr Gly Ala Gln Val Lys Leu Pro Asp 2390 2395 2400 Gly Ile Thr Thr Asn Val Val Lys Tyr Thr Gln Leu Cys Gln Tyr 2405 2410 2415 Leu Asn Thr Thr Thr Leu Cys Val Pro His Lys Met Arg Val Leu 2420 2425 2430 His Leu Gly Ala Ala Gly Ala Ser Gly Val Ala Pro Gly Ser Thr 2435 2440 2445 Val Leu Arg Arg Trp Leu Pro Asp Asp Ala Ile Leu Val Asp Asn 2450 2455 2460 Asp Leu Arg Asp Tyr Val Ser Asp Ala Asp Phe Ser Val Thr Gly 2465 2470 2475 Asp Cys Thr Ser Leu Tyr Ile Glu Asp Lys Phe Asp Leu Leu Val 2480 2485 2490 Ser Asp Leu Tyr Asp Gly Ser Thr Lys Ser Ile Asp Gly Glu Asn 2495 2500 2505 Thr Ser Lys Asp Gly Phe Phe Thr Tyr Ile Asn Gly Phe Ile Lys 2510 2515 2520 Glu Lys Leu Ser Leu Gly Gly Ser Val Ala Ile Lys Ile Thr Glu 2525 2530 2535 Phe Ser Trp Asn Lys Asp Leu Tyr Glu Leu Ile Gln Arg Phe Glu 2540 2545 2550 Tyr Trp Thr Val Phe Cys Thr Ser Val Asn Thr Ser Ser Ser Glu 2555 2560 2565 Gly Phe Leu Ile Gly Ile Asn Tyr Leu Gly Pro Tyr Cys Asp Lys 2570 2575 2580 Ala Ile Val Asp Gly Asn Ile Met His Ala Asn Tyr Ile Phe Trp 2585 2590 2595 Arg Asn Ser Thr Ile Met Ala Leu Ser His Asn Ser Val Leu Asp 2600 2605 2610 Thr Pro Lys Phe Lys Cys Arg Cys Asn Asn Ala Leu Ile Val Asn 2615 2620 2625 Leu Lys Glu Lys Glu Leu Asn Glu Met Val Ile Gly Leu Leu Arg 2630 2635 2640 Lys Gly Lys Leu Leu Ile Arg Asn Asn Gly Lys Leu Leu Asn Phe 2645 2650 2655 Gly Asn His Phe Val Asn Thr Pro 2660 2665 <210> 30 <211> 1447 <212> PRT <213> transmissible gastroenteritus virus <220> <221> MISC_FEATURE <223> Spike protein <400> 30 Met Lys Lys Leu Phe Val Val Leu Val Val Met Pro Leu Ile Tyr Gly 1 5 10 15 Asp Asn Phe Pro Cys Ser Lys Leu Thr Asn Arg Thr Ile Gly Asn Gln 20 25 30 Trp Asn Leu Ile Glu Thr Phe Leu Leu Asn Tyr Ser Ser Arg Leu Pro 35 40 45 Pro Asn Ser Asp Val Val Leu Gly Asp Tyr Phe Pro Thr Val Gln Pro 50 55 60 Trp Phe Asn Cys Ile Arg Asn Asp Ser Asn Asp Leu Tyr Val Thr Leu 65 70 75 80 Glu Asn Leu Lys Ala Leu Tyr Trp Asp Tyr Ala Thr Glu Asn Ile Thr 85 90 95 Trp Asn His Arg Gln Arg Leu Asn Val Val Val Asn Gly Tyr Pro Tyr 100 105 110 Ser Ile Thr Val Thr Thr Thr Arg Asn Phe Asn Ser Ala Glu Gly Ala 115 120 125 Ile Ile Cys Ile Cys Lys Gly Ser Pro Pro Thr Thr Thr Thr Glu Ser 130 135 140 Ser Leu Thr Cys Asn Trp Gly Ser Glu Cys Arg Leu Asn His Lys Phe 145 150 155 160 Pro Ile Cys Pro Ser Asn Ser Glu Ala Asn Cys Gly Asn Met Leu Tyr 165 170 175 Gly Leu Gln Trp Phe Ala Asp Glu Val Val Ala Tyr Leu His Gly Ala 180 185 190 Ser Tyr Arg Ile Ser Phe Glu Asn Gln Trp Ser Gly Thr Val Thr Phe 195 200 205 Gly Asp Met Arg Ala Thr Thr Leu Glu Val Ala Gly Thr Leu Val Asp 210 215 220 Leu Trp Trp Phe Asn Pro Val Tyr Asp Val Ser Tyr Tyr Arg Val Asn 225 230 235 240 Asn Lys Asn Gly Thr Thr Val Val Ser Asn Cys Thr Asp Gln Cys Ala 245 250 255 Ser Tyr Val Ala Asn Val Phe Thr Thr Gln Pro Gly Gly Phe Ile Pro 260 265 270 Ser Asp Phe Ser Phe Asn Asn Trp Phe Leu Leu Thr Asn Ser Ser Thr 275 280 285 Leu Val Ser Gly Lys Leu Val Thr Lys Gln Pro Leu Leu Val Asn Cys 290 295 300 Leu Trp Pro Val Pro Ser Phe Glu Glu Ala Ala Ser Thr Phe Cys Phe 305 310 315 320 Glu Gly Ala Gly Phe Asp Gln Cys Asn Gly Ala Val Leu Asn Asn Thr 325 330 335 Val Asp Val Ile Arg Phe Asn Leu Asn Phe Thr Thr Asn Val Gln Ser 340 345 350 Gly Lys Gly Ala Thr Val Phe Ser Leu Asn Thr Thr Gly Gly Val Thr 355 360 365 Leu Glu Ile Ser Cys Tyr Thr Val Ser Asp Ser Ser Phe Phe Ser Tyr 370 375 380 Gly Glu Ile Pro Phe Gly Val Thr Asp Gly Pro Arg Tyr Cys Tyr Val 385 390 395 400 His Tyr Asn Gly Thr Ala Leu Lys Tyr Leu Gly Thr Leu Pro Pro Ser 405 410 415 Val Lys Glu Ile Ala Ile Ser Lys Trp Gly His Phe Tyr Ile Asn Gly 420 425 430 Tyr Asn Phe Phe Ser Thr Phe Pro Ile Asp Cys Ile Ser Phe Asn Leu 435 440 445 Thr Thr Gly Asp Ser Asp Val Phe Trp Thr Ile Ala Tyr Thr Ser Tyr 450 455 460 Thr Glu Ala Leu Val Gln Val Glu Asn Thr Ala Ile Thr Lys Val Thr 465 470 475 480 Tyr Cys Asn Ser His Val Asn Asn Ile Lys Cys Ser Gln Ile Thr Ala 485 490 495 Asn Leu Asn Asn Gly Phe Tyr Pro Val Ser Ser Ser Glu Val Gly Leu 500 505 510 Val Asn Lys Ser Val Val Leu Leu Pro Ser Phe Tyr Thr His Thr Ile 515 520 525 Val Asn Ile Thr Ile Gly Leu Gly Met Lys Arg Ser Gly Tyr Gly Gln 530 535 540 Pro Ile Ala Ser Thr Leu Ser Asn Ile Thr Leu Pro Met Gln Asp His 545 550 555 560 Asn Thr Asp Val Tyr Cys Ile Arg Ser Asp Gln Phe Ser Val Tyr Val 565 570 575 His Ser Thr Cys Lys Ser Ala Leu Trp Asp Asn Ile Phe Lys Arg Asn 580 585 590 Cys Thr Asp Val Leu Asp Ala Thr Ala Val Ile Lys Thr Gly Thr Cys 595 600 605 Pro Phe Ser Phe Asp Lys Leu Asn Asn Tyr Leu Thr Phe Asn Lys Phe 610 615 620 Cys Leu Ser Leu Ser Pro Val Gly Ala Asn Cys Lys Phe Asp Val Ala 625 630 635 640 Ala Arg Thr Arg Thr Asn Glu Gln Val Val Arg Ser Leu Tyr Val Ile 645 650 655 Tyr Glu Glu Gly Asp Asn Ile Val Gly Val Pro Ser Asp Asn Ser Gly 660 665 670 Val His Asp Leu Ser Val Leu His Leu Asp Ser Cys Thr Asp Tyr Asn 675 680 685 Ile Tyr Gly Arg Thr Gly Val Gly Ile Ile Arg Gln Thr Asn Arg Thr 690 695 700 Leu Leu Ser Gly Leu Tyr Tyr Thr Ser Leu Ser Gly Asp Leu Leu Gly 705 710 715 720 Phe Lys Asn Val Ser Asp Gly Val Ile Tyr Ser Val Thr Pro Cys Asp 725 730 735 Val Ser Ala Gln Ala Ala Val Ile Asp Gly Thr Ile Val Gly Ala Ile 740 745 750 Thr Ser Ile Asn Ser Glu Leu Leu Gly Leu Thr His Trp Thr Thr Thr 755 760 765 Pro Asn Phe Tyr Tyr Tyr Ser Ile Tyr Asn Tyr Thr Asn Asp Arg Thr 770 775 780 Arg Gly Thr Ala Ile Asp Ser Asn Asp Val Asp Cys Glu Pro Val Ile 785 790 795 800 Thr Tyr Ser Asn Ile Gly Val Cys Lys Asn Gly Ala Phe Val Phe Ile 805 810 815 Asn Val Thr His Ser Asp Gly Asp Val Gln Pro Ile Ser Thr Gly Asn 820 825 830 Val Thr Ile Pro Thr Asn Phe Thr Ile Ser Val Gln Val Glu Tyr Ile 835 840 845 Gln Val Tyr Thr Thr Pro Val Ser Ile Asp Cys Ser Arg Tyr Val Cys 850 855 860 Asn Gly Asn Pro Arg Cys Asn Lys Leu Leu Thr Gln Tyr Val Ser Ala 865 870 875 880 Cys Gln Thr Ile Glu Gln Ala Leu Ala Met Gly Ala Arg Leu Glu Asn 885 890 895 Met Glu Val Asp Ser Met Leu Phe Val Ser Glu Asn Ala Leu Lys Leu 900 905 910 Ala Ser Val Glu Ala Phe Asn Ser Ser Glu Thr Leu Asp Pro Ile Tyr 915 920 925 Lys Glu Trp Pro Asn Ile Gly Gly Ser Trp Leu Glu Gly Leu Lys Tyr 930 935 940 Ile Leu Pro Ser His Asn Ser Lys Arg Lys Tyr Arg Ser Ala Ile Glu 945 950 955 960 Asp Leu Leu Phe Asp Lys Val Val Thr Ser Gly Leu Gly Thr Val Asp 965 970 975 Glu Asp Tyr Lys Arg Cys Thr Gly Gly Tyr Asp Ile Ala Asp Leu Val 980 985 990 Cys Ala Gln Tyr Tyr Asn Gly Ile Met Val Leu Pro Gly Val Ala Asn 995 1000 1005 Ala Asp Lys Met Thr Met Tyr Thr Ala Ser Leu Ala Gly Gly Ile 1010 1015 1020 Thr Leu Gly Ala Leu Gly Gly Gly Ala Val Ala Ile Pro Phe Ala 1025 1030 1035 Val Ala Val Gln Ala Arg Leu Asn Tyr Val Ala Leu Gln Thr Asp 1040 1045 1050 Val Leu Asn Lys Asn Gln Gln Ile Leu Ala Ser Ala Phe Asn Gln 1055 1060 1065 Ala Ile Gly Asn Ile Thr Gln Ser Phe Gly Lys Val Asn Asp Ala 1070 1075 1080 Ile His Gln Thr Ser Arg Gly Leu Ala Thr Val Ala Lys Ala Leu 1085 1090 1095 Ala Lys Val Gln Asp Val Val Asn Ile Gln Gly Gln Ala Leu Ser 1100 1105 1110 His Leu Thr Val Gln Leu Gln Asn Asn Phe Gln Ala Ile Ser Ser 1115 1120 1125 Ser Ile Ser Asp Ile Tyr Asn Arg Leu Asp Glu Leu Ser Ala Asp 1130 1135 1140 Ala Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Thr Ala Leu Asn 1145 1150 1155 Ala Phe Val Ser Gln Thr Leu Thr Arg Gln Ala Glu Val Arg Ala 1160 1165 1170 Ser Arg Gln Leu Ala Lys Asp Lys Val Asn Glu Cys Val Arg Ser 1175 1180 1185 Gln Ser Gln Arg Phe Gly Phe Cys Gly Asn Gly Thr His Leu Phe 1190 1195 1200 Ser Leu Ala Asn Ala Ala Pro Asn Gly Met Ile Phe Phe His Thr 1205 1210 1215 Val Leu Leu Pro Thr Ala Tyr Glu Thr Val Thr Ala Trp Pro Gly 1220 1225 1230 Ile Cys Ala Ser Asp Gly Asp Arg Thr Phe Gly Leu Val Val Lys 1235 1240 1245 Asp Val Gln Leu Thr Leu Phe Arg Asn Leu Asp Asp Lys Phe Tyr 1250 1255 1260 Leu Thr Pro Arg Thr Met Tyr Gln Pro Arg Val Ala Thr Ser Ser 1265 1270 1275 Asp Phe Val Gln Ile Glu Gly Cys Asp Val Leu Phe Val Asn Ala 1280 1285 1290 Thr Val Ser Asp Leu Pro Ser Ile Ile Pro Asp Tyr Ile Asp Ile 1295 1300 1305 Asn Gln Thr Val Gln Asp Ile Leu Glu Asn Phe Arg Pro Asn Trp 1310 1315 1320 Thr Val Pro Glu Leu Thr Phe Asp Ile Phe Asn Ala Thr Tyr Leu 1325 1330 1335 Asn Leu Thr Gly Glu Ile Asp Asp Leu Glu Phe Arg Ser Glu Lys 1340 1345 1350 Leu His Asn Thr Thr Val Glu Leu Ala Ile Leu Ile Asp Asn Ile 1355 1360 1365 Asn Asn Thr Leu Val Asn Leu Glu Trp Leu Asn Arg Ile Glu Thr 1370 1375 1380 Tyr Val Lys Trp Pro Trp Tyr Val Trp Leu Leu Ile Gly Leu Val 1385 1390 1395 Val Ile Phe Cys Ile Pro Leu Leu Leu Phe Cys Cys Cys Ser Thr 1400 1405 1410 Gly Cys Cys Gly Cys Ile Gly Cys Leu Gly Ser Cys Cys His Ser 1415 1420 1425 Ile Cys Ser Arg Arg Gln Phe Glu Asn Tyr Glu Pro Ile Glu Lys 1430 1435 1440 Val His Val His 1445 <210> 31 <211> 1162 <212> PRT <213> avian infectious bronchitis virus <220> <221> MISC_FEATURE <223> spike protein <400> 31 Met Leu Val Thr Pro Leu Leu Leu Val Thr Leu Leu Cys Ala Leu Cys 1 5 10 15 Ser Ala Val Leu Tyr Asp Ser Ser Ser Tyr Val Tyr Tyr Tyr Gln Ser 20 25 30 Ala Phe Arg Pro Pro Ser Gly Trp His Leu Gln Gly Gly Ala Tyr Ala 35 40 45 Val Val Asn Ile Ser Ser Glu Phe Asn Asn Ala Gly Ser Ser Ser Gly 50 55 60 Cys Thr Val Gly Ile Ile His Gly Gly Arg Val Val Asn Ala Ser Ser 65 70 75 80 Ile Ala Met Thr Ala Pro Ser Ser Gly Met Ala Trp Ser Ser Ser Gln 85 90 95 Phe Cys Thr Ala His Cys Asn Phe Ser Asp Thr Thr Val Phe Val Thr 100 105 110 His Cys Tyr Lys His Gly Gly Cys Pro Leu Thr Gly Met Leu Gln Gln 115 120 125 Asn Leu Ile Arg Val Ser Ala Met Lys Asn Gly Gln Leu Phe Tyr Asn 130 135 140 Leu Thr Val Ser Val Ala Lys Tyr Pro Thr Phe Arg Ser Phe Gln Cys 145 150 155 160 Val Asn Asn Leu Thr Ser Val Tyr Leu Asn Gly Asp Leu Val Tyr Thr 165 170 175 Ser Asn Glu Thr Ile Asp Val Thr Ser Ala Gly Val Tyr Phe Lys Ala 180 185 190 Gly Gly Pro Ile Thr Tyr Lys Val Met Arg Glu Val Lys Ala Leu Ala 195 200 205 Tyr Phe Val Asn Gly Thr Ala Gln Asp Val Ile Leu Cys Asp Gly Ser 210 215 220 Pro Arg Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly Asn Phe Ser Asp 225 230 235 240 Gly Phe Tyr Pro Phe Thr Asn Ser Ser Leu Val Lys Gln Lys Phe Ile 245 250 255 Val Tyr Arg Glu Asn Ser Val Asn Thr Thr Cys Thr Leu His Asn Phe 260 265 270 Ile Phe His Asn Glu Thr Gly Ala Asn Pro Asn Pro Ser Gly Val Gln 275 280 285 Asn Ile Gln Thr Tyr Gln Thr Lys Thr Ala Gln Ser Gly Tyr Tyr Asn 290 295 300 Phe Asn Phe Ser Phe Leu Ser Ser Phe Val Tyr Lys Glu Ser Asn Phe 305 310 315 320 Met Tyr Gly Ser Tyr His Pro Ser Cys Lys Phe Arg Leu Glu Thr Ile 325 330 335 Asn Asn Gly Leu Trp Phe Asn Ser Leu Ser Val Ser Ile Ala Tyr Gly 340 345 350 Pro Leu Gln Gly Gly Cys Lys Gln Ser Val Phe Lys Gly Arg Ala Thr 355 360 365 Cys Cys Tyr Ala Tyr Ser Tyr Gly Gly Pro Ser Leu Cys Lys Gly Val 370 375 380 Tyr Ser Gly Glu Leu Asp His Asn Phe Glu Cys Gly Leu Leu Val Tyr 385 390 395 400 Val Thr Lys Ser Gly Gly Ser Arg Ile Gln Thr Ala Thr Glu Pro Pro 405 410 415 Val Ile Thr Gln Asn Asn Tyr Asn Asn Ile Thr Leu Asn Thr Cys Val 420 425 430 Asp Tyr Asn Ile Tyr Gly Arg Thr Gly Gln Gly Phe Ile Thr Asn Val 435 440 445 Thr Asp Ser Ala Val Ser Tyr Asn Tyr Leu Ala Asp Ala Gly Leu Ala 450 455 460 Ile Leu Asp Thr Ser Gly Ser Ile Asp Ile Phe Val Val Gln Gly Glu 465 470 475 480 Tyr Gly Leu Asn Tyr Tyr Lys Val Asn Pro Cys Glu Asp Val Asn Gln 485 490 495 Gln Phe Val Val Ser Gly Gly Lys Leu Val Gly Ile Leu Thr Ser Arg 500 505 510 Asn Glu Thr Gly Ser Gln Leu Leu Glu Asn Gln Phe Tyr Ile Lys Ile 515 520 525 Thr Asn Gly Thr Arg Arg Phe Arg Arg Ser Ile Thr Glu Asn Val Ala 530 535 540 Asn Cys Pro Tyr Val Ser Tyr Gly Lys Phe Cys Ile Lys Pro Asp Gly 545 550 555 560 Ser Ile Ala Thr Ile Val Pro Lys Gln Leu Glu Gln Phe Val Ala Pro 565 570 575 Leu Phe Asn Val Thr Glu Asn Val Leu Ile Pro Asn Ser Phe Asn Leu 580 585 590 Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg Met Asp Lys Val Gln Ile 595 600 605 Asn Cys Leu Gln Tyr Val Cys Gly Ser Ser Leu Asp Cys Arg Lys Leu 610 615 620 Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn Ile Leu Ser Val Val Asn 625 630 635 640 Ser Val Gly Gln Lys Glu Asp Met Glu Leu Leu Asn Phe Tyr Ser Ser 645 650 655 Thr Lys Pro Ala Gly Phe Asn Thr Pro Val Leu Ser Asn Val Ser Thr 660 665 670 Gly Glu Phe Asn Ile Ser Leu Leu Leu Thr Asn Pro Ser Ser Arg Arg 675 680 685 Lys Arg Ser Leu Ile Glu Asp Leu Leu Phe Thr Ser Val Glu Ser Val 690 695 700 Gly Leu Pro Thr Asn Asp Ala Tyr Lys Asn Cys Thr Ala Gly Pro Leu 705 710 715 720 Gly Phe Phe Lys Asp Leu Ala Cys Ala Arg Glu Tyr Asn Gly Leu Leu 725 730 735 Val Leu Pro Pro Ile Ile Thr Ala Glu Met Gln Ala Leu Tyr Thr Ser 740 745 750 Ser Leu Val Ala Ser Met Ala Phe Gly Gly Ile Thr Ala Ala Gly Ala 755 760 765 Ile Pro Phe Ala Thr Gln Leu Gln Ala Arg Ile Asn His Leu Gly Ile 770 775 780 Thr Gln Ser Leu Leu Leu Lys Asn Gln Glu Lys Ile Ala Ala Ser Phe 785 790 795 800 Asn Lys Ala Ile Gly His Met Gln Glu Gly Phe Arg Ser Thr Ser Leu 805 810 815 Ala Leu Gln Gln Ile Gln Asp Val Val Ser Lys Gln Ser Ala Ile Leu 820 825 830 Thr Glu Thr Met Ala Ser Leu Asn Lys Asn Phe Gly Ala Ile Ser Ser 835 840 845 Val Ile Gln Glu Ile Tyr Gln Gln Phe Asp Ala Ile Gln Ala Asn Ala 850 855 860 Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ser Ser Leu Ser Val Leu 865 870 875 880 Ala Ser Ala Lys Gln Ala Glu Tyr Ile Arg Val Ser Gln Gln Arg Glu 885 890 895 Leu Ala Thr Gln Lys Ile Asn Glu Cys Val Lys Ser Gln Ser Ile Arg 900 905 910 Tyr Ser Phe Cys Gly Asn Gly Arg His Val Leu Thr Ile Pro Gln Asn 915 920 925 Ala Pro Asn Gly Ile Val Phe Ile His Phe Ser Tyr Thr Pro Asp Ser 930 935 940 Phe Val Asn Val Thr Ala Ile Val Gly Phe Cys Val Lys Pro Ala Asn 945 950 955 960 Ala Ser Gln Tyr Ala Ile Val Pro Ala Asn Gly Arg Gly Ile Phe Ile 965 970 975 Gln Val Asn Gly Ser Tyr Tyr Ile Thr Ala Arg Asp Met Tyr Met Pro 980 985 990 Arg Ala Ile Thr Ala Gly Asp Val Val Thr Leu Thr Ser Cys Gln Ala 995 1000 1005 Asn Tyr Val Ser Val Asn Lys Thr Val Ile Thr Thr Phe Val Asp 1010 1015 1020 Asn Asp Asp Phe Asp Phe Asn Asp Glu Leu Ser Lys Trp Trp Asn 1025 1030 1035 Asp Thr Lys His Glu Leu Pro Asp Phe Asp Lys Phe Asn Tyr Thr 1040 1045 1050 Val Pro Ile Leu Asp Ile Asp Ser Glu Ile Asp Arg Ile Gln Gly 1055 1060 1065 Val Ile Gln Gly Leu Asn Asp Ser Leu Ile Asp Leu Glu Lys Leu 1070 1075 1080 Ser Ile Leu Lys Thr Tyr Ile Lys Trp Pro Trp Tyr Val Trp Leu 1085 1090 1095 Ala Ile Ala Phe Ala Thr Ile Ile Phe Ile Leu Ile Leu Gly Trp 1100 1105 1110 Val Phe Phe Met Thr Gly Cys Cys Gly Cys Cys Cys Gly Cys Phe 1115 1120 1125 Gly Ile Met Pro Leu Met Ser Lys Cys Gly Lys Lys Ser Ser Tyr 1130 1135 1140 Tyr Thr Thr Phe Asp Asn Asp Val Val Thr Glu Gln Tyr Arg Pro 1145 1150 1155 Lys Lys Ser Val 1160 <210> 32 <211> 1363 <212> PRT <213> bovine coronavirus <220> <221> MISC_FEATURE <223> spike protein <400> 32 Met Phe Leu Ile Leu Leu Ile Ser Leu Pro Met Ala Phe Ala Val Ile 1 5 10 15 Gly Asp Leu Lys Cys Thr Thr Val Ser Ile Asn Asp Val Asp Thr Gly 20 25 30 Ala Pro Ser Ile Ser Thr Asp Ile Val Asp Val Thr Asn Gly Leu Gly 35 40 45 Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr Leu Leu Leu 50 55 60 Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn Met Ala Leu 65 70 75 80 Lys Gly Thr Leu Leu Leu Ser Arg Leu Trp Phe Lys Pro Pro Phe Leu 85 90 95 Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn Thr Lys Val 100 105 110 Ile Lys Lys Gly Val Met Tyr Ser Glu Phe Pro Ala Ile Thr Ile Gly 115 120 125 Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln Pro His Thr 130 135 140 Thr Asn Leu Asp Asn Lys Leu Gln Gly Leu Leu Glu Ile Ser Val Cys 145 150 155 160 Gln Tyr Thr Met Cys Glu Tyr Pro His Thr Ile Cys His Pro Lys Leu 165 170 175 Gly Asn Lys Arg Val Glu Leu Trp His Trp Asp Thr Gly Val Val Ser 180 185 190 Cys Leu Tyr Lys Arg Asn Phe Thr Tyr Asp Val Asn Ala Asp Tyr Leu 195 200 205 Tyr Phe His Phe Tyr Gln Glu Gly Gly Thr Phe Tyr Ala Tyr Phe Thr 210 215 220 Asp Thr Gly Val Val Thr Lys Phe Leu Phe Asn Val Tyr Leu Gly Thr 225 230 235 240 Val Leu Ser His Tyr Tyr Val Leu Pro Leu Thr Cys Ser Ser Ala Met 245 250 255 Thr Leu Glu Tyr Trp Val Thr Pro Leu Thr Ser Lys Gln Tyr Leu Leu 260 265 270 Ala Phe Asn Gln Asp Gly Val Ile Phe Asn Ala Val Asp Cys Lys Ser 275 280 285 Asp Phe Met Ser Glu Ile Lys Cys Lys Thr Leu Ser Ile Ala Pro Ser 290 295 300 Thr Gly Val Tyr Glu Leu Asn Gly Tyr Thr Val Gln Pro Ile Ala Asp 305 310 315 320 Val Tyr Arg Arg Ile Pro Asn Leu Pro Asp Cys Asn Ile Glu Ala Trp 325 330 335 Leu Asn Asp Lys Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Thr 340 345 350 Phe Ser Asn Cys Asn Phe Asn Met Ser Ser Leu Met Ser Phe Ile Gln 355 360 365 Ala Asp Ser Phe Thr Cys Asn Asn Ile Asp Ala Ala Lys Ile Tyr Gly 370 375 380 Met Cys Phe Ser Ser Ile Thr Ile Asp Lys Phe Ala Ile Pro Asn Gly 385 390 395 400 Arg Lys Val Asp Leu Gln Leu Gly Asn Leu Gly Tyr Leu Gln Ser Phe 405 410 415 Asn Tyr Arg Ile Asp Thr Thr Ala Thr Ser Cys Gln Leu Tyr Tyr Asn 420 425 430 Leu Pro Ala Ala Asn Val Ser Val Ser Arg Phe Asn Pro Ser Thr Trp 435 440 445 Asn Arg Arg Phe Gly Phe Thr Glu Gln Phe Val Phe Lys Pro Gln Pro 450 455 460 Val Gly Val Phe Thr His His Asp Val Val Tyr Ala Gln His Cys Phe 465 470 475 480 Lys Ala Pro Lys Asn Phe Cys Pro Cys Lys Leu Asp Gly Ser Leu Cys 485 490 495 Val Gly Asn Gly Pro Gly Ile Asp Ala Gly Tyr Lys Asn Ser Gly Ile 500 505 510 Gly Thr Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys His Asn Ala Ala 515 520 525 Gln Cys Asp Cys Leu Cys Thr Pro Asp Pro Ile Thr Ser Lys Ser Thr 530 535 540 Gly Pro Tyr Lys Cys Pro Gln Thr Lys Tyr Leu Val Gly Ile Gly Glu 545 550 555 560 His Cys Ser Gly Leu Ala Ile Lys Ser Asp Tyr Cys Gly Gly Asn Pro 565 570 575 Cys Thr Cys Gln Pro Gln Ala Phe Leu Gly Trp Ser Val Asp Ser Cys 580 585 590 Leu Gln Gly Asp Arg Cys Asn Ile Phe Ala Asn Phe Ile Phe His Asp 595 600 605 Val Asn Ser Gly Thr Thr Cys Ser Thr Asp Leu Gln Lys Ser Asn Thr 610 615 620 Asp Ile Ile Leu Gly Val Cys Val Asn Tyr Asp Leu Tyr Gly Ile Thr 625 630 635 640 Gly Gln Gly Ile Phe Val Glu Val Asn Ala Thr Tyr Tyr Asn Ser Trp 645 650 655 Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn Leu Tyr Gly Phe Arg Asp 660 665 670 Tyr Leu Thr Asn Arg Thr Phe Met Ile Arg Ser Cys Tyr Ser Gly Arg 675 680 685 Val Ser Ala Ala Phe His Ala Asn Ser Ser Glu Pro Ala Leu Leu Phe 690 695 700 Arg Asn Ile Lys Cys Asn Tyr Val Phe Asn Asn Thr Leu Ser Arg Gln 705 710 715 720 Leu Gln Pro Ile Asn Tyr Phe Asp Ser Tyr Leu Gly Cys Val Val Asn 725 730 735 Ala Asp Asn Ser Thr Ser Ser Val Val Gln Thr Cys Asp Leu Thr Val 740 745 750 Gly Ser Gly Tyr Cys Val Asp Tyr Ser Thr Lys Arg Arg Ser Arg Arg 755 760 765 Ala Ile Thr Thr Gly Tyr Arg Phe Thr Asn Phe Glu Pro Phe Thr Val 770 775 780 Asn Ser Val Asn Asp Ser Leu Glu Pro Val Gly Gly Leu Tyr Glu Ile 785 790 795 800 Gln Ile Pro Ser Glu Phe Thr Ile Gly Asn Met Glu Glu Phe Ile Gln 805 810 815 Thr Ser Ser Pro Lys Val Thr Ile Asp Cys Ser Ala Phe Val Cys Gly 820 825 830 Asp Tyr Ala Ala Cys Lys Ser Gln Leu Val Glu Tyr Gly Ser Phe Cys 835 840 845 Asp Asn Ile Asn Ala Ile Leu Thr Glu Val Asn Glu Leu Leu Asp Thr 850 855 860 Thr Gln Leu Gln Val Ala Asn Ser Leu Met Asn Gly Val Thr Leu Ser 865 870 875 880 Thr Lys Leu Lys Asp Gly Val Asn Phe Asn Val Asp Asp Ile Asn Phe 885 890 895 Ser Pro Val Leu Gly Cys Leu Gly Ser Ala Cys Asn Lys Val Ser Ser 900 905 910 Arg Ser Ala Ile Glu Asp Leu Leu Phe Ser Lys Val Lys Leu Ser Asp 915 920 925 Val Gly Phe Val Glu Ala Tyr Asn Asn Cys Thr Gly Gly Ala Glu Ile 930 935 940 Arg Asp Leu Ile Cys Val Gln Ser Tyr Asn Gly Ile Lys Val Leu Pro 945 950 955 960 Pro Leu Leu Ser Val Asn Gln Ile Ser Gly Tyr Thr Leu Ala Ala Thr 965 970 975 Ser Ala Ser Leu Phe Pro Pro Leu Ser Ala Ala Val Gly Val Pro Phe 980 985 990 Tyr Leu Asn Val Gln Tyr Arg Ile Asn Gly Ile Gly Val Thr Met Asp 995 1000 1005 Val Leu Ser Gln Asn Gln Lys Leu Ile Ala Asn Ala Phe Asn Asn 1010 1015 1020 Ala Leu Asp Ala Ile Gln Glu Gly Phe Asp Ala Thr Asn Ser Ala 1025 1030 1035 Leu Val Lys Ile Gln Ala Val Val Asn Ala Asn Ala Glu Ala Leu 1040 1045 1050 Asn Asn Leu Leu Gln Gln Leu Ser Asn Arg Phe Gly Ala Ile Ser 1055 1060 1065 Ser Ser Leu Gln Glu Ile Leu Ser Arg Leu Asp Ala Leu Glu Ala 1070 1075 1080 Gln Ala Gln Ile Asp Arg Leu Ile Asn Gly Arg Leu Thr Ala Leu 1085 1090 1095 Asn Val Tyr Val Ser Gln Gln Leu Ser Asp Ser Thr Leu Val Lys 1100 1105 1110 Phe Ser Ala Ala Gln Ala Met Glu Lys Val Asn Glu Cys Val Lys 1115 1120 1125 Ser Gln Ser Ser Arg Ile Asn Phe Cys Gly Asn Gly Asn His Ile 1130 1135 1140 Ile Ser Leu Val Gln Asn Ala Pro Tyr Gly Leu Tyr Phe Ile His 1145 1150 1155 Phe Ser Tyr Val Pro Thr Lys Tyr Val Thr Ala Lys Val Ser Pro 1160 1165 1170 Gly Leu Cys Ile Ala Gly Asp Arg Gly Ile Ala Pro Lys Ser Gly 1175 1180 1185 Tyr Phe Val Asn Val Asn Asn Thr Trp Met Phe Thr Gly Ser Gly 1190 1195 1200 Tyr Tyr Tyr Pro Glu Pro Ile Thr Gly Asn Asn Val Val Val Met 1205 1210 1215 Ser Thr Cys Ala Val Asn Tyr Thr Lys Ala Pro Asp Val Met Leu 1220 1225 1230 Asn Ile Ser Thr Pro Asn Leu His Asp Phe Lys Glu Glu Leu Asp 1235 1240 1245 Gln Trp Phe Lys Asn Gln Thr Ser Val Ala Pro Asp Leu Ser Leu 1250 1255 1260 Asp Tyr Ile Asn Val Thr Phe Leu Asp Leu Gln Asp Glu Met Asn 1265 1270 1275 Arg Leu Gln Glu Ala Ile Lys Val Leu Asn Gln Ser Tyr Ile Asn 1280 1285 1290 Leu Lys Asp Ile Gly Thr Tyr Glu Tyr Tyr Val Lys Trp Pro Trp 1295 1300 1305 Tyr Val Trp Leu Leu Ile Gly Phe Ala Gly Val Ala Met Leu Val 1310 1315 1320 Leu Leu Phe Phe Ile Cys Cys Cys Thr Gly Cys Gly Thr Ser Cys 1325 1330 1335 Phe Lys Ile Cys Gly Gly Cys Cys Asp Asp Tyr Thr Gly His Gln 1340 1345 1350 Glu Leu Val Ile Lys Thr Ser His Asp Asp 1355 1360 <210> 33 <211> 1451 <212> PRT <213> canine coronavirus <220> <221> MISC_FEATURE <223> spike protein <400> 33 Met Ile Val Leu Thr Leu Cys Leu Phe Leu Phe Leu Tyr Ser Ser Val 1 5 10 15 Ser Cys Thr Ser Asn Asn Asp Cys Val Gln Val Asn Val Thr Gln Leu 20 25 30 Pro Gly Asn Glu Asn Ile Ile Lys Asp Phe Leu Phe Gln Asn Phe Lys 35 40 45 Glu Glu Gly Ser Leu Val Val Gly Gly Tyr Tyr Pro Thr Glu Val Trp 50 55 60 Tyr Asn Cys Ser Thr Thr Gln Gln Thr Thr Ala Tyr Lys Tyr Phe Ser 65 70 75 80 Asn Ile His Ala Phe Tyr Phe Asp Met Glu Ala Met Glu Asn Ser Thr 85 90 95 Gly Asn Ala Arg Gly Lys Pro Leu Leu Val His Val His Gly Asn Pro 100 105 110 Val Ser Ile Ile Val Tyr Ile Ser Ala Tyr Arg Asp Asp Val Gln Phe 115 120 125 Arg Pro Leu Leu Lys His Gly Leu Leu Cys Ile Thr Lys Asn Asp Thr 130 135 140 Val Asp Tyr Asn Ser Phe Thr Ile Asn Gln Trp Arg Asp Ile Cys Leu 145 150 155 160 Gly Asp Asp Arg Lys Ile Pro Phe Ser Val Val Pro Thr Asp Asn Gly 165 170 175 Thr Lys Leu Phe Gly Leu Glu Trp Asn Asp Asp Tyr Val Thr Ala Tyr 180 185 190 Ile Ser Asp Glu Ser His Arg Leu Asn Ile Asn Asn Asn Trp Phe Asn 195 200 205 Asn Val Thr Leu Leu Tyr Ser Arg Thr Ser Thr Ala Thr Trp Gln His 210 215 220 Ser Ala Ala Tyr Val Tyr Gln Gly Val Ser Asn Phe Thr Tyr Tyr Lys 225 230 235 240 Leu Asn Lys Thr Ala Gly Leu Lys Ser Tyr Glu Leu Cys Glu Asp Tyr 245 250 255 Glu Tyr Cys Thr Gly Tyr Ala Thr Asn Val Phe Ala Pro Thr Ser Gly 260 265 270 Gly Tyr Ile Pro Asp Gly Phe Ser Phe Asn Asn Trp Phe Met Leu Thr 275 280 285 Asn Ser Ser Thr Phe Val Ser Gly Arg Phe Val Thr Asn Gln Pro Leu 290 295 300 Leu Val Asn Cys Leu Trp Pro Val Pro Ser Phe Gly Val Ala Ala Gln 305 310 315 320 Glu Phe Cys Phe Glu Gly Ala Gln Phe Ser Gln Cys Asn Gly Val Ser 325 330 335 Leu Asn Asn Thr Val Asp Val Ile Arg Phe Asn Leu Asn Phe Thr Thr 340 345 350 Asp Val Gln Ser Gly Met Gly Ala Thr Val Phe Ser Leu Asn Thr Thr 355 360 365 Gly Gly Val Ile Leu Glu Ile Ser Cys Tyr Asn Asp Thr Val Ser Glu 370 375 380 Ser Ser Phe Tyr Ser Tyr Gly Glu Ile Pro Phe Gly Val Thr Asp Gly 385 390 395 400 Pro Arg Tyr Cys Tyr Val Leu Tyr Asn Gly Thr Ala Leu Lys Tyr Leu 405 410 415 Gly Thr Leu Pro Pro Ser Val Lys Glu Ile Ala Ile Ser Lys Trp Gly 420 425 430 His Phe Tyr Ile Asn Gly Tyr Asn Phe Phe Ser Thr Phe Pro Ile Asp 435 440 445 Cys Ile Ala Phe Asn Leu Thr Thr Gly Ala Ser Gly Ala Phe Trp Thr 450 455 460 Ile Ala Tyr Thr Ser Tyr Thr Glu Ala Leu Val Gln Val Glu Asn Thr 465 470 475 480 Ala Ile Lys Lys Val Thr Tyr Cys Asn Ser His Ile Asn Asn Ile Lys 485 490 495 Cys Ser Gln Leu Thr Ala Asn Leu Gln Asn Gly Phe Tyr Pro Val Ala 500 505 510 Ser Ser Glu Val Gly Leu Val Asn Lys Ser Val Val Leu Leu Pro Ser 515 520 525 Phe Tyr Ser His Thr Ser Val Asn Ile Thr Ile Asp Leu Gly Met Lys 530 535 540 Arg Ser Val Thr Val Thr Ile Ala Ser Pro Leu Ser Asn Ile Thr Leu 545 550 555 560 Pro Met Gln Asp Asn Asn Ile Asp Val Tyr Cys Ile Arg Ser Asn Gln 565 570 575 Phe Ser Val Tyr Val His Ser Thr Cys Lys Ser Ser Leu Trp Asp Asn 580 585 590 Asn Phe Asn Ser Ala Cys Thr Asp Val Leu Asp Ala Thr Ala Val Ile 595 600 605 Lys Thr Gly Thr Cys Pro Phe Ser Phe Asp Lys Leu Asn Asn Tyr Leu 610 615 620 Thr Phe Asn Lys Phe Cys Leu Ser Leu Asn Pro Val Gly Ala Asn Cys 625 630 635 640 Lys Leu Asp Val Ala Ala Arg Thr Arg Thr Asn Glu Gln Val Phe Gly 645 650 655 Ser Leu Tyr Val Ile Tyr Glu Glu Gly Asp Asn Ile Val Gly Val Pro 660 665 670 Ser Asp Asn Ser Gly Leu His Asp Leu Ser Val Leu His Leu Asp Ser 675 680 685 Cys Thr Asp Tyr Asn Ile Tyr Gly Arg Thr Gly Val Gly Ile Ile Arg 690 695 700 Lys Thr Asn Ser Thr Leu Leu Ser Gly Leu Tyr Tyr Thr Ser Leu Ser 705 710 715 720 Gly Asp Leu Leu Gly Phe Lys Asn Val Ser Asp Gly Val Val Tyr Ser 725 730 735 Val Thr Pro Cys Asp Val Ser Ala Gln Ala Ala Val Ile Asp Gly Ala 740 745 750 Ile Val Gly Ala Met Thr Ser Ile Asn Ser Glu Leu Leu Gly Leu Thr 755 760 765 His Trp Thr Thr Thr Pro Asn Phe Tyr Tyr Tyr Ser Ile Tyr Asn Tyr 770 775 780 Thr Asn Val Met Asn Arg Gly Thr Ala Ile Asp Asn Asp Ile Asp Cys 785 790 795 800 Glu Pro Ile Ile Thr Tyr Ser Asn Ile Gly Val Cys Lys Asn Gly Ala 805 810 815 Leu Val Phe Ile Asn Val Thr His Ser Asp Gly Asp Val Gln Pro Ile 820 825 830 Ser Thr Gly Asn Val Thr Ile Pro Thr Asn Phe Thr Ile Ser Val Gln 835 840 845 Val Glu Tyr Ile Gln Val Tyr Thr Thr Pro Val Ser Ile Asp Cys Ala 850 855 860 Arg Tyr Val Cys Asn Gly Asn Pro Arg Cys Asn Lys Leu Leu Thr Gln 865 870 875 880 Tyr Val Ser Ala Cys Gln Thr Ile Glu Gln Ala Leu Ala Met Gly Ala 885 890 895 Arg Leu Glu Asn Met Glu Ile Asp Ser Met Leu Phe Val Ser Glu Asn 900 905 910 Ala Leu Lys Leu Ala Ser Val Glu Ala Phe Asn Ser Thr Glu Asn Leu 915 920 925 Asp Pro Ile Tyr Lys Glu Trp Pro Asn Ile Gly Gly Ser Trp Leu Gly 930 935 940 Gly Leu Lys Asp Ile Leu Pro Ser His Asn Ser Lys Arg Lys Tyr Arg 945 950 955 960 Ser Ala Ile Glu Asp Leu Leu Phe Asp Lys Val Val Thr Ser Gly Leu 965 970 975 Gly Thr Val Asp Glu Asp Tyr Lys Arg Ser Ala Gly Gly Tyr Asp Ile 980 985 990 Ala Asp Leu Val Cys Ala Arg Tyr Tyr Asn Gly Ile Met Val Leu Pro 995 1000 1005 Gly Val Ala Asn Asp Asp Lys Met Thr Met Tyr Thr Ala Ser Leu 1010 1015 1020 Thr Gly Gly Ile Thr Leu Gly Ala Leu Ser Gly Gly Ala Val Ala 1025 1030 1035 Ile Pro Phe Ala Val Ala Val Gln Ala Arg Leu Asn Tyr Val Ala 1040 1045 1050 Leu Gln Thr Asp Val Leu Asn Lys Asn Gln Gln Ile Leu Ala Asn 1055 1060 1065 Ala Phe Asn Gln Ala Ile Gly Asn Ile Thr Gln Ala Phe Gly Lys 1070 1075 1080 Val Asn Asp Ala Ile His Gln Thr Ser Lys Gly Leu Ala Thr Val 1085 1090 1095 Ala Lys Ala Leu Ala Lys Val Gln Asp Val Val Asn Thr Gln Gly 1100 1105 1110 Gln Ala Leu Ser His Leu Thr Val Gln Leu Gln Asn Asn Phe Gln 1115 1120 1125 Ala Ile Ser Ser Ser Ile Ser Asp Ile Tyr Asn Arg Leu Asp Glu 1130 1135 1140 Leu Ser Ala Asp Ala Gln Val Asp Arg Leu Ile Thr Gly Arg Leu 1145 1150 1155 Thr Ala Leu Asn Ala Phe Val Ser Gln Thr Leu Thr Arg Gln Ala 1160 1165 1170 Glu Val Arg Ala Ser Arg Gln Leu Ala Lys Asp Lys Val Asn Glu 1175 1180 1185 Cys Val Arg Ser Gln Ser Gln Arg Phe Gly Phe Cys Gly Asn Gly 1190 1195 1200 Thr His Leu Phe Ser Leu Ala Asn Ala Ala Pro Asn Gly Met Ile 1205 1210 1215 Phe Phe His Thr Val Leu Leu Pro Thr Ala Tyr Glu Thr Val Thr 1220 1225 1230 Ala Trp Ser Gly Ile Cys Ala Ser Asp Gly Ser Arg Thr Phe Gly 1235 1240 1245 Leu Val Val Glu Asp Val Gln Leu Thr Leu Phe Arg Asn Leu Asp 1250 1255 1260 Glu Lys Phe Tyr Leu Thr Pro Arg Thr Met Tyr Gln Pro Arg Val 1265 1270 1275 Ala Thr Ser Ser Asp Phe Val Gln Ile Glu Gly Cys Asp Val Leu 1280 1285 1290 Phe Val Asn Gly Thr Val Ile Glu Leu Pro Ser Ile Ile Pro Asp 1295 1300 1305 Tyr Ile Asp Ile Asn Gln Thr Val Gln Asp Ile Leu Glu Asn Phe 1310 1315 1320 Arg Pro Asn Trp Thr Val Pro Glu Leu Pro Leu Asp Ile Phe His 1325 1330 1335 Ala Thr Tyr Leu Asn Leu Thr Gly Glu Ile Asn Asp Leu Glu Phe 1340 1345 1350 Arg Ser Glu Lys Leu His Asn Thr Thr Val Glu Leu Ala Ile Leu 1355 1360 1365 Ile Asp Asn Ile Asn Asn Thr Leu Val Asn Leu Glu Trp Leu Asn 1370 1375 1380 Arg Ile Glu Thr Tyr Val Lys Trp Pro Trp Tyr Val Trp Leu Leu 1385 1390 1395 Ile Gly Leu Val Val Ile Phe Cys Ile Pro Ile Leu Leu Phe Cys 1400 1405 1410 Cys Cys Ser Thr Gly Cys Cys Gly Cys Ile Gly Cys Leu Gly Ser 1415 1420 1425 Cys Cys His Ser Ile Cys Ser Arg Gly Gln Phe Glu Ser Tyr Glu 1430 1435 1440 Pro Ile Glu Lys Val His Val His 1445 1450 <210> 34 <211> 1355 <212> PRT <213> EMCR Coronavirus <220> <221> MISC_FEATURE <223> spike protein <400> 34 Met Lys Leu Phe Leu Ile Leu Leu Ile Leu Pro Leu Val Ser Cys Phe 1 5 10 15 Ser Thr Cys Asn Ser Asn Ala Ser Ile Ser Met Leu Gln Leu Gly Val 20 25 30 Pro Asp Asn Ser Ser Thr Ile Val Thr Gly Leu Leu Pro Val His Trp 35 40 45 Ile Cys Ala Asn Gln Ser Thr Ser Ser Tyr Pro Ala Asn Gly Phe Phe 50 55 60 Tyr Ile Asp Val Gly Lys His Arg Ser Ala Phe Ala Leu His Ser Gly 65 70 75 80 Tyr Tyr Asp Ala Asn Gln Tyr Tyr Ile Tyr Leu Thr Asn Lys Ile His 85 90 95 Leu Asn Ala Pro Val Thr Leu Lys Ile Cys Lys Phe Gly Asn Thr Ser 100 105 110 Phe Asp Phe Leu Ser Asn Val Ser Thr Ser His Asp Cys Ile Val Asn 115 120 125 Leu Ser Phe Thr Glu Gln Leu Gly Val Pro Leu Gly Ile Thr Ile Ser 130 135 140 Gly Glu Thr Val Arg Leu His Leu Tyr Asn Ala Thr Arg Thr Phe Tyr 145 150 155 160 Val Pro Ala Ala Tyr Lys Leu Thr Lys Leu Ser Val Lys Cys Tyr Phe 165 170 175 Ser Glu Ser Cys Val Phe Ser Val Val Asn Ala Thr Ile Thr Val Asn 180 185 190 Val Thr Thr Leu Asn Gly Arg Ile Val Asn Tyr Thr Val Cys Asp Asp 195 200 205 Cys Asn Gly Tyr Thr Asp Asn Ile Phe Ser Val Gln Gln Asp Gly Arg 210 215 220 Ile Pro Asn Gly Phe Pro Phe Asn Asn Trp Phe Leu Leu Thr Asn Gly 225 230 235 240 Ser Thr Leu Val Asp Gly Val Ser Arg Leu Tyr Gln Pro Leu Arg Leu 245 250 255 Thr Cys Leu Trp Pro Val Pro Gly Leu Lys Ser Ser Thr Gly Phe Val 260 265 270 Tyr Phe Asn Ala Thr Gly Ser Asp Val Asn Cys Asn Gly Tyr Gln His 275 280 285 Asn Ser Val Ala Asp Val Met Arg Tyr Asn Leu Asn Leu Ser Ala Asn 290 295 300 Ser Val Asp Asn Leu Lys Ser Gly Val Ile Val Phe Lys Thr Leu Gln 305 310 315 320 Tyr Asp Val Leu Phe Tyr Cys Ser Asn Ser Ser Ser Gly Val Leu Asp 325 330 335 Thr Thr Ile Pro Phe Gly Pro Ser Ser Gln Pro Tyr Tyr Cys Phe Ile 340 345 350 Asn Ser Thr Ile Asn Thr Thr His Val Ser Thr Phe Val Gly Ile Leu 355 360 365 Pro Pro Thr Val Arg Glu Ile Val Val Ala Arg Thr Gly Gln Phe Tyr 370 375 380 Ile Asn Gly Phe Lys Tyr Phe Asp Leu Gly Phe Ile Glu Ala Val Asn 385 390 395 400 Phe Asn Val Thr Thr Ala Ser Ala Thr Asp Phe Trp Thr Val Ala Phe 405 410 415 Ala Thr Phe Val Asp Val Leu Val Asn Val Ser Ala Thr Asn Ile Gln 420 425 430 Asn Leu Leu Tyr Cys Asp Ser Pro Phe Glu Lys Leu Gln Cys Glu His 435 440 445 Leu Gln Phe Gly Leu Gln Asp Gly Phe Tyr Ser Ala Asn Phe Leu Asp 450 455 460 Asp Asn Val Leu Pro Glu Thr Tyr Val Ala Leu Pro Ile Tyr Tyr Gln 465 470 475 480 His Thr Asp Ile Asn Phe Thr Ala Thr Ala Ser Phe Gly Gly Ser Cys 485 490 495 Tyr Val Cys Lys Pro Arg Gln Val Asn Ile Ser Leu Asn Gly Asn Thr 500 505 510 Ser Val Cys Val Arg Thr Ser His Phe Ser Ile Arg Tyr Ile Tyr Asn 515 520 525 Arg Val Lys Ser Gly Ser Pro Gly Asp Ser Ser Trp His Ile Tyr Leu 530 535 540 Lys Ser Gly Thr Cys Pro Phe Ser Phe Ser Lys Leu Asn Asn Phe Gln 545 550 555 560 Lys Phe Lys Thr Ile Cys Phe Ser Thr Val Glu Val Pro Gly Ser Cys 565 570 575 Asn Phe Pro Leu Glu Ala Thr Trp His Tyr Thr Ser Tyr Thr Ile Val 580 585 590 Gly Ala Leu Tyr Val Thr Trp Ser Glu Gly Asn Ser Ile Thr Gly Val 595 600 605 Pro Tyr Pro Val Ser Gly Ile Arg Glu Phe Ser Asn Leu Val Leu Asn 610 615 620 Asn Cys Thr Lys Tyr Asn Ile Tyr Asp Tyr Val Gly Thr Gly Ile Ile 625 630 635 640 Arg Ser Ser Asn Gln Ser Leu Ala Gly Gly Ile Thr Tyr Val Ser Asn 645 650 655 Ser Gly Asn Leu Leu Gly Phe Lys Asn Val Ser Thr Gly Asn Ile Phe 660 665 670 Ile Val Thr Pro Cys Asn Gln Pro Asp Gln Val Ala Val Tyr Gln Gln 675 680 685 Ser Ile Ile Gly Ala Met Thr Ala Val Asn Glu Ser Arg Tyr Gly Leu 690 695 700 Gln Asn Leu Leu Gln Leu Pro Asn Phe Tyr Tyr Val Ser Asn Gly Gly 705 710 715 720 Asn Asn Cys Thr Thr Ala Val Met Ile Tyr Ser Asn Phe Gly Ile Cys 725 730 735 Ala Asp Gly Ser Leu Ile Pro Val Arg Pro Arg Asn Ser Ser Asp Asn 740 745 750 Gly Ile Ser Ala Ile Ile Thr Ala Asn Leu Ser Ile Pro Ser Asn Trp 755 760 765 Thr Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro Ile 770 775 780 Val Val Asp Cys Ala Thr Tyr Val Cys Asn Gly Asn Pro Arg Cys Lys 785 790 795 800 Asn Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp Ala 805 810 815 Leu Arg Leu Ser Ala His Leu Glu Thr Asn Asp Val Ser Ser Met Leu 820 825 830 Thr Phe Asp Ser Asn Ala Phe Ser Leu Ala Asn Val Thr Ser Phe Gly 835 840 845 Asp Tyr Asn Leu Ser Ser Val Leu Pro Gln Arg Asn Ile His Ser Ser 850 855 860 Arg Ile Ala Gly Arg Ser Ala Leu Glu Asp Leu Leu Phe Ser Lys Val 865 870 875 880 Val Thr Ser Gly Leu Gly Thr Val Asp Val Asp Tyr Lys Ser Cys Thr 885 890 895 Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn Gly 900 905 910 Ile Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met Tyr 915 920 925 Thr Gly Ser Leu Ile Gly Gly Met Val Leu Gly Gly Leu Thr Ser Ala 930 935 940 Ala Ala Ile Pro Phe Ser Leu Ala Leu Gln Ala Arg Leu Asn Tyr Val 945 950 955 960 Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala Ala 965 970 975 Ser Phe Asn Lys Ala Ile Asn Asn Ile Val Ala Ser Phe Ser Ser Val 980 985 990 Asn Asp Ala Ile Thr His Thr Ala Glu Ala Ile His Thr Val Thr Ile 995 1000 1005 Ala Leu Asn Lys Ile Gln Asp Val Val Asn Gln Gln Gly Ser Ala 1010 1015 1020 Leu Asn His Leu Thr Ser Gln Leu Arg His Asn Phe Gln Ala Ile 1025 1030 1035 Ser Asn Ser Ile His Ala Ile Tyr Asp Arg Leu Asp Ser Ile Gln 1040 1045 1050 Ala Asp Gln Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ala Ala 1055 1060 1065 Leu Asn Ala Phe Val Ser Gln Val Leu Asn Lys Tyr Thr Glu Val 1070 1075 1080 Arg Gly Ser Arg Arg Leu Ala Gln Gln Lys Ile Asn Glu Cys Val 1085 1090 1095 Lys Ser Gln Ser Asn Arg Tyr Gly Phe Cys Gly Asn Gly Thr His 1100 1105 1110 Ile Phe Ser Ile Val Asn Ser Ala Pro Asp Gly Leu Leu Phe Leu 1115 1120 1125 His Thr Val Leu Leu Pro Thr Asp Tyr Lys Asn Val Lys Ala Trp 1130 1135 1140 Ser Gly Ile Cys Val Asp Gly Ile Tyr Gly Tyr Val Leu Arg Gln 1145 1150 1155 Pro Asn Leu Val Leu Tyr Ser Asp Asn Gly Val Phe Arg Val Thr 1160 1165 1170 Ser Arg Val Met Phe Gln Pro Arg Leu Pro Val Leu Ser Asp Phe 1175 1180 1185 Val Gln Ile Tyr Asn Cys Asn Val Thr Phe Val Asn Ile Ser Arg 1190 1195 1200 Val Glu Leu His Thr Val Ile Pro Asp Tyr Val Asp Val Asn Lys 1205 1210 1215 Thr Leu Gln Glu Phe Ala Gln Asn Leu Pro Lys Tyr Val Lys Pro 1220 1225 1230 Asn Phe Asp Leu Thr Pro Phe Asn Leu Thr Tyr Leu Asn Leu Ser 1235 1240 1245 Ser Glu Leu Lys Gln Leu Glu Ala Lys Thr Ala Ser Leu Phe Gln 1250 1255 1260 Thr Thr Val Glu Leu Gln Gly Leu Ile Asp Gln Ile Asn Ser Thr 1265 1270 1275 Tyr Val Asp Leu Lys Leu Leu Asn Arg Phe Glu Asn Tyr Ile Lys 1280 1285 1290 Trp Pro Trp Trp Val Trp Leu Ile Ile Ser Val Val Phe Val Val 1295 1300 1305 Leu Leu Ser Leu Leu Val Phe Cys Cys Leu Ser Thr Gly Cys Cys 1310 1315 1320 Gly Cys Cys Asn Cys Leu Thr Ser Ser Met Arg Gly Cys Cys Asp 1325 1330 1335 Cys Gly Ser Thr Lys Leu Pro Tyr Tyr Glu Phe Glu Lys Val His 1340 1345 1350 Val Gln 1355 <210> 35 <211> 1452 <212> PRT <213> feline coronavirus <220> <221> MISC_FEATURE <223> spike protein <400> 35 Met Ile Val Leu Val Thr Cys Leu Leu Leu Leu Cys Ser Tyr His Thr 1 5 10 15 Val Leu Ser Thr Thr Asn Asn Glu Cys Ile Gln Val Asn Val Thr Gln 20 25 30 Leu Ala Gly Asn Glu Asn Leu Ile Arg Asp Phe Leu Phe Ser Asn Phe 35 40 45 Lys Glu Glu Gly Ser Val Val Val Gly Gly Tyr Tyr Pro Thr Glu Val 50 55 60 Trp Tyr Asn Cys Ser Arg Thr Ala Arg Thr Thr Ala Phe Gln Tyr Phe 65 70 75 80 Asn Asn Ile His Ala Phe Tyr Phe Val Met Glu Ala Met Glu Asn Ser 85 90 95 Thr Gly Asn Ala Arg Gly Lys Pro Leu Leu Phe His Val His Gly Glu 100 105 110 Pro Val Ser Val Ile Ile Ser Ala Tyr Arg Asp Asp Val Gln Gln Arg 115 120 125 Pro Leu Leu Lys His Gly Leu Val Cys Ile Thr Lys Asn Arg His Ile 130 135 140 Asn Tyr Glu Gln Phe Thr Ser Asn Gln Trp Asn Ser Thr Cys Thr Gly 145 150 155 160 Ala Asp Arg Lys Ile Pro Phe Ser Val Ile Pro Thr Asp Asn Gly Thr 165 170 175 Lys Ile Tyr Gly Leu Glu Trp Asn Asp Asp Phe Val Thr Ala Tyr Ile 180 185 190 Ser Gly Arg Ser Tyr His Leu Asn Ile Asn Thr Asn Trp Phe Asn Asn 195 200 205 Val Thr Leu Leu Tyr Ser Arg Ser Ser Thr Ala Thr Trp Glu Tyr Ser 210 215 220 Ala Ala Tyr Ala Tyr Gln Gly Val Ser Asn Phe Thr Tyr Tyr Lys Leu 225 230 235 240 Asn Asn Thr Asn Gly Leu Lys Thr Tyr Glu Leu Cys Glu Asp Tyr Glu 245 250 255 His Cys Thr Gly Tyr Ala Thr Asn Val Phe Ala Pro Thr Ser Gly Gly 260 265 270 Tyr Ile Pro Asp Gly Phe Ser Phe Asn Asn Trp Phe Leu Leu Thr Asn 275 280 285 Ser Ser Thr Phe Val Ser Gly Arg Phe Val Thr Asn Gln Pro Leu Leu 290 295 300 Ile Asn Cys Leu Trp Pro Val Pro Ser Phe Gly Val Ala Ala Gln Glu 305 310 315 320 Phe Cys Phe Glu Gly Ala Gln Phe Ser Gln Cys Asn Gly Val Ser Leu 325 330 335 Asn Asn Thr Val Asp Val Ile Arg Phe Asn Leu Asn Phe Thr Ala Asp 340 345 350 Val Gln Ser Gly Met Gly Ala Thr Val Phe Ser Leu Asn Thr Thr Gly 355 360 365 Gly Val Ile Leu Glu Ile Ser Cys Tyr Ser Asp Thr Val Ser Glu Ser 370 375 380 Ser Ser Tyr Ser Tyr Gly Glu Ile Pro Phe Gly Ile Thr Asp Gly Pro 385 390 395 400 Arg Tyr Cys Tyr Val Leu Tyr Asn Gly Thr Ala Leu Lys Tyr Leu Gly 405 410 415 Thr Leu Pro Pro Ser Val Lys Glu Ile Ala Ile Ser Lys Trp Gly His 420 425 430 Phe Tyr Ile Asn Gly Tyr Asn Phe Phe Ser Thr Phe Pro Ile Gly Cys 435 440 445 Ile Ser Phe Asn Leu Thr Thr Gly Val Ser Gly Ala Phe Trp Thr Ile 450 455 460 Ala Tyr Thr Ser Tyr Thr Glu Ala Leu Val Gln Val Glu Asn Thr Ala 465 470 475 480 Ile Lys Asn Val Thr Tyr Cys Asn Ser His Ile Asn Asn Ile Lys Cys 485 490 495 Ser Gln Leu Thr Ala Asn Leu Asn Asn Gly Phe Tyr Pro Val Ala Ser 500 505 510 Ser Glu Val Gly Phe Val Asn Lys Ser Val Val Leu Leu Pro Ser Phe 515 520 525 Phe Thr Tyr Thr Ala Val Asn Ile Thr Ile Asp Leu Gly Met Lys Leu 530 535 540 Ser Gly Tyr Gly Gln Pro Ile Ala Ser Thr Leu Ser Asn Ile Thr Leu 545 550 555 560 Pro Met Gln Asp Asn Asn Thr Asp Val Tyr Cys Ile Arg Ser Asn Gln 565 570 575 Phe Ser Val Tyr Val His Ser Thr Cys Lys Ser Ser Leu Trp Asp Asn 580 585 590 Ile Phe Asn Gln Asp Cys Thr Asp Val Leu Glu Ala Thr Ala Val Ile 595 600 605 Lys Thr Gly Thr Cys Pro Phe Ser Phe Asp Lys Leu Asn Asn Tyr Leu 610 615 620 Thr Phe Asn Lys Phe Cys Leu Ser Leu Ser Pro Val Gly Ala Asn Cys 625 630 635 640 Lys Phe Asp Val Ala Ala Arg Thr Arg Thr Asn Glu Gln Val Val Arg 645 650 655 Ser Leu Tyr Val Ile Tyr Glu Glu Gly Asp Asn Ile Val Gly Val Pro 660 665 670 Ser Asp Asn Ser Gly Leu His Asp Leu Ser Val Leu His Leu Asp Ser 675 680 685 Cys Thr Asp Tyr Asn Ile Tyr Gly Arg Thr Gly Val Gly Ile Ile Arg 690 695 700 Arg Thr Asn Ser Thr Leu Leu Ser Gly Leu Tyr Tyr Thr Ser Leu Ser 705 710 715 720 Gly Asp Leu Leu Gly Phe Lys Asn Val Ser Asp Gly Val Ile Tyr Ser 725 730 735 Val Thr Pro Cys Asp Val Ser Ala Gln Ala Ala Val Ile Asp Gly Ala 740 745 750 Ile Val Gly Ala Met Thr Ser Ile Asn Ser Glu Leu Leu Gly Leu Thr 755 760 765 His Trp Thr Thr Thr Pro Asn Phe Tyr Tyr Tyr Ser Ile Tyr Asn Tyr 770 775 780 Thr Ser Glu Arg Thr Arg Gly Thr Ala Ile Asp Ser Asn Asp Val Asp 785 790 795 800 Cys Glu Pro Val Ile Thr Tyr Ser Asn Ile Gly Val Cys Lys Asn Gly 805 810 815 Ala Leu Val Phe Ile Asn Val Thr His Ser Asp Gly Asp Val Gln Pro 820 825 830 Ile Ser Thr Gly Asn Val Thr Ile Pro Thr Asn Phe Thr Ile Ser Val 835 840 845 Gln Val Glu Tyr Met Gln Val Tyr Thr Thr Pro Val Ser Ile Asp Cys 850 855 860 Ala Arg Tyr Val Cys Asn Gly Asn Pro Arg Cys Asn Lys Leu Leu Thr 865 870 875 880 Gln Tyr Val Ser Ala Cys Gln Thr Ile Glu Gln Ala Leu Ala Met Gly 885 890 895 Ala Arg Leu Glu Asn Met Glu Val Asp Ser Met Leu Phe Val Ser Glu 900 905 910 Asn Ala Leu Lys Leu Ala Ser Val Glu Ala Phe Asn Ser Thr Glu Asn 915 920 925 Leu Asp Pro Ile Tyr Lys Glu Trp Pro Ser Ile Gly Gly Ser Trp Leu 930 935 940 Gly Gly Leu Lys Asp Ile Leu Pro Ser His Asn Ser Lys Arg Lys Tyr 945 950 955 960 Gly Ser Ala Ile Glu Asp Leu Leu Phe Asp Lys Val Val Thr Ser Gly 965 970 975 Leu Gly Thr Val Asp Glu Asp Tyr Lys Arg Cys Thr Gly Gly Tyr Asp 980 985 990 Ile Ala Asp Leu Val Cys Ala Gln Tyr Tyr Asn Gly Ile Met Val Leu 995 1000 1005 Pro Gly Val Ala Asn Ala Asp Lys Met Thr Met Tyr Thr Ala Ser 1010 1015 1020 Leu Ala Gly Gly Ile Thr Leu Gly Ala Leu Gly Gly Gly Ala Val 1025 1030 1035 Ala Ile Pro Phe Ala Val Ala Val Gln Ala Arg Leu Asn Tyr Val 1040 1045 1050 Ala Leu Gln Thr Asp Val Leu Asn Lys Asn Gln Gln Ile Leu Ala 1055 1060 1065 Asn Ala Phe Asn Gln Ala Ile Gly Asn Ile Thr Gln Ala Phe Gly 1070 1075 1080 Lys Val Asn Asp Ala Ile His Gln Thr Ser Gln Gly Leu Ala Thr 1085 1090 1095 Val Ala Lys Ala Leu Ala Lys Val Gln Asp Val Val Asn Thr Gln 1100 1105 1110 Gly Gln Ala Leu Ser His Leu Thr Val Gln Leu Gln Asn Asn Phe 1115 1120 1125 Gln Ala Ile Ser Ser Ser Ile Ser Asp Ile Tyr Asn Arg Leu Asp 1130 1135 1140 Glu Leu Ser Ala Asp Ala Gln Val Asp Arg Leu Ile Thr Gly Arg 1145 1150 1155 Leu Thr Ala Leu Asn Ala Phe Val Ser Gln Thr Leu Thr Arg Gln 1160 1165 1170 Ala Glu Val Arg Ala Ser Arg Gln Leu Ala Lys Asp Lys Val Asn 1175 1180 1185 Glu Cys Val Arg Ser Gln Ser Gln Arg Phe Gly Phe Cys Gly Asn 1190 1195 1200 Gly Thr His Leu Phe Ser Leu Ala Asn Ala Ala Pro Asn Gly Met 1205 1210 1215 Ile Phe Phe His Thr Val Leu Leu Pro Thr Ala Tyr Glu Thr Val 1220 1225 1230 Thr Ala Trp Ser Gly Ile Cys Ala Ser Asp Gly Asp Arg Thr Phe 1235 1240 1245 Gly Leu Val Val Lys Asp Val Gln Leu Thr Leu Phe Arg Asn Leu 1250 1255 1260 Asp Asp Lys Phe Tyr Leu Thr Pro Arg Thr Met Tyr Gln Pro Arg 1265 1270 1275 Val Ala Thr Ser Ser Asp Phe Val Gln Ile Glu Gly Cys Asp Val 1280 1285 1290 Leu Phe Val Asn Ala Thr Val Ile Asp Leu Pro Ser Ile Ile Pro 1295 1300 1305 Asp Tyr Ile Asp Ile Asn Gln Thr Val Gln Asp Ile Leu Glu Asn 1310 1315 1320 Tyr Arg Pro Asn Trp Thr Val Pro Glu Phe Thr Leu Asp Ile Phe 1325 1330 1335 Asn Ala Thr Tyr Leu Asn Leu Thr Gly Glu Ile Asp Asp Leu Glu 1340 1345 1350 Phe Arg Ser Glu Lys Leu His Asn Thr Thr Val Glu Leu Ala Ile 1355 1360 1365 Leu Ile Asp Asn Ile Asn Asn Thr Leu Val Asn Leu Glu Trp Leu 1370 1375 1380 Asn Arg Ile Glu Thr Tyr Val Lys Trp Pro Trp Tyr Val Trp Leu 1385 1390 1395 Leu Ile Gly Leu Val Val Val Phe Cys Ile Pro Leu Leu Leu Phe 1400 1405 1410 Cys Cys Phe Ser Thr Gly Cys Cys Gly Cys Ile Gly Cys Leu Gly 1415 1420 1425 Ser Cys Cys His Ser Ile Cys Ser Arg Arg Gln Phe Glu Asn Tyr 1430 1435 1440 Glu Pro Ile Glu Lys Val His Val His 1445 1450 <210> 36 <211> 1361 <212> PRT <213> murine hepatitis virus <220> <221> MISC_FEATURE <223> spike protein <400> 36 Met Leu Phe Val Phe Leu Thr Leu Leu Pro Ser Ser Leu Gly Tyr Ile 1 5 10 15 Gly Asp Phe Arg Cys Ile Gln Leu Val Asn Thr Asp Thr Ser Asn Ala 20 25 30 Ser Ala Pro Ser Val Ser Thr Glu Val Val Asp Val Ser Lys Gly Ile 35 40 45 Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Ala Thr Leu Leu 50 55 60 Leu Thr Gly Tyr Tyr Pro Val Asp Gly Ser Met Tyr Arg Asn Met Ala 65 70 75 80 Leu Thr Gly Ile Asn Thr Ile Ser Leu Asn Trp Tyr Lys Pro Pro Phe 85 90 95 Leu Ser Glu Phe Asn Asp Gly Ile Phe Ala Lys Val Lys Asn Leu Lys 100 105 110 Ala Ser Leu Pro Lys Asp Ser Ile Ser Tyr Phe Pro Thr Ile Ile Ile 115 120 125 Gly Ser Asn Phe Val Thr Thr Ser Tyr Thr Val Val Leu Glu Pro Tyr 130 135 140 Asn Gly Ile Ile Met Ala Ser Ile Cys Gln Tyr Thr Ile Cys Gln Leu 145 150 155 160 Pro Tyr Thr Asp Cys Lys Pro Asn Thr Gly Gly Asn Lys Leu Ile Gly 165 170 175 Phe Trp His Thr Glu Leu Lys Ser Pro Val Cys Ile Leu Lys Arg Asn 180 185 190 Phe Thr Phe Asn Val Asn Ala Glu Trp Leu Tyr Phe His Phe Tyr Gln 195 200 205 Gln Gly Gly Thr Phe Tyr Ala Tyr Tyr Ala Asp Val Ser Ser Ala Thr 210 215 220 Thr Phe Leu Phe Ser Met Tyr Ile Gly Asp Val Leu Thr Gln Tyr Phe 225 230 235 240 Val Leu Pro Tyr Met Cys Thr Leu Thr Thr Thr Gly Val Phe Ser Pro 245 250 255 Gln Tyr Trp Val Thr Pro Leu Val Lys Arg Gln Tyr Leu Phe Asn Phe 260 265 270 Asn Gln Lys Gly Ile Ile Thr Ser Ala Val Asp Cys Ala Ser Ser Tyr 275 280 285 Thr Ser Glu Ile Lys Cys Lys Thr Gln Ser Met Asn Pro Asn Thr Gly 290 295 300 Val Tyr Asp Leu Ser Gly Tyr Thr Val Gln Pro Val Gly Leu Val Tyr 305 310 315 320 Arg Arg Val Arg Asn Leu Pro Asp Cys Lys Ile Glu Glu Trp Leu Thr 325 330 335 Ala Lys Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Thr Phe Gln 340 345 350 Asn Cys Asn Phe Asp Leu Ser Ser Leu Leu Arg Phe Val Gln Ala Glu 355 360 365 Ser Leu Ser Cys Ser Asn Ile Asp Ala Ser Lys Val Tyr Gly Met Cys 370 375 380 Phe Gly Ser Ile Ser Ile Asp Lys Phe Ala Ile Pro Asn Arg Arg Arg 385 390 395 400 Val Asp Leu Gln Leu Gly Asn Ser Gly Phe Leu Gln Ser Phe Asn Tyr 405 410 415 Lys Ile Asp Thr Arg Ala Thr Ser Cys Gln Leu Tyr Tyr Ser Leu Ala 420 425 430 Lys Asn Asn Val Thr Val Asn Asn His Asn Pro Ser Ser Trp Asn Arg 435 440 445 Arg Tyr Gly Phe Asn Asp Val Ala Thr Phe Gly Thr Gly Lys His Asp 450 455 460 Val Ala Tyr Ala Glu Ala Cys Phe Thr Val Gly Ala Ser Tyr Cys Pro 465 470 475 480 Cys Ala Asn Pro Ser Ile Val Ser Pro Cys Thr Thr Gly Lys Pro Asn 485 490 495 Phe Ala Asn Cys Pro Thr Gly Thr Ser Asn Arg Glu Cys Thr Val Met 500 505 510 Pro Leu Ala Asn Asn Gln Phe Lys Cys Asp Cys Thr Cys Asn Pro Ser 515 520 525 Pro Leu Thr Thr Tyr Asp Leu Arg Cys Leu Gln Ala Arg Ser Met Leu 530 535 540 Gly Val Gly Asp His Cys Glu Gly Leu Gly Val Leu Glu Asp Lys Cys 545 550 555 560 Gly Gly Ser Asn Thr Cys Asn Cys Ser Ala His Ala Phe Val Gly Trp 565 570 575 Ala Lys Asp Ser Cys Leu Ala Asn Gly Arg Cys His Ile Phe Ser Asn 580 585 590 Leu Met Leu Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Met Asp Leu 595 600 605 Gln Leu Pro Asn Thr Glu Val Val Thr Gly Val Cys Val Lys Tyr Asp 610 615 620 Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Lys Ala Asp 625 630 635 640 Tyr Tyr His Ser Trp Gln Asn Leu Leu Tyr Asp Val Asn Gly Asn Leu 645 650 655 Ile Gly Phe Arg Asp Phe Val Ala Asn Lys Ser Tyr Thr Ile Arg Ser 660 665 670 Cys Tyr Ser Gly Arg Val Ser Ala Ala Tyr His Gln Asp Ala Pro Glu 675 680 685 Pro Ala Leu Leu Tyr Arg Asn Leu Lys Cys Asp Tyr Val Phe Asn Asn 690 695 700 Asn Ile Ser Arg Glu Glu Thr Pro Leu Asn Tyr Phe Asp Ser Tyr Leu 705 710 715 720 Gly Cys Val Val Asn Ala Asp Asn Ser Thr Glu Glu Ala Val Asp Ala 725 730 735 Cys Asp Leu Arg Met Gly Ser Gly Leu Cys Val Asn Tyr Ser Thr Ser 740 745 750 His Arg Ala Arg Ser Ser Val Ser Thr Gly Tyr Lys Leu Thr Thr Phe 755 760 765 Glu Pro Phe Thr Val Arg Ile Val Asn Asp Ser Val Glu Ser Val Asp 770 775 780 Gly Leu Tyr Glu Leu Gln Ile Pro Thr Asn Phe Thr Ile Ala Ser His 785 790 795 800 Gln Glu Phe Val Gln Thr Arg Ser Pro Lys Val Thr Ile Asp Cys Ala 805 810 815 Ala Phe Val Cys Gly Gly His Thr Ala Cys Arg Gln Gln Leu Val Glu 820 825 830 Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu Gly Glu Val Asn 835 840 845 Asn Leu Ile Asp Thr Met Gln Leu Gln Val Ala Ser Ala Leu Ile Gln 850 855 860 Gly Val Thr Leu Ser Ser Arg Leu Ser Asp Gly Ile Gly Gly Gln Ile 865 870 875 880 Asp Asp Ile Asn Phe Ser Pro Leu Leu Gly Cys Leu Gly Ser Asp Cys 885 890 895 Gly Glu Val Thr Met Ala Ala Gln Thr Gly Arg Ser Ala Ile Glu Asp 900 905 910 Val Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala 915 920 925 Tyr Asn Asn Cys Thr Gly Gly Gln Glu Val Arg Asp Leu Leu Cys Val 930 935 940 Gln Ser Phe Asn Gly Ile Lys Val Leu Pro Pro Val Leu Ser Glu Asn 945 950 955 960 Gln Ile Ser Gly Tyr Thr Ala Gly Ala Thr Val Ser Ala Met Phe Pro 965 970 975 Trp Ser Ala Ala Ala Gly Val Pro Phe Ser Leu Ser Val Gln Tyr Arg 980 985 990 Ile Asn Gly Leu Gly Val Thr Met Asn Val Leu Ser Glu Asn Gln Lys 995 1000 1005 Met Ile Ala Ser Ala Phe Asn Asn Ala Ile Gly Ala Ile Gln Glu 1010 1015 1020 Gly Phe Ala Ala Thr Asn Ser Ala Leu Ala Lys Met Gln Phe Val 1025 1030 1035 Val Asn Ala Asn Ala Glu Ala Leu Asn Asn Leu Leu Asn Gln Leu 1040 1045 1050 Ser Asn Arg Phe Gly Ala Ile Ser Ala Ser Leu Gln Glu Ile Leu 1055 1060 1065 Ser Arg Leu Asp Ala Leu Glu Ala Gln Ala Gln Ile Asp Arg Leu 1070 1075 1080 Ile Asn Gly Arg Leu Thr Ala Leu Asn Ala Tyr Val Ser Lys Gln 1085 1090 1095 Leu Ser Asp Met Thr Leu Val Lys Val Ser Ala Ala Gln Ala Ile 1100 1105 1110 Glu Lys Val Asn Glu Cys Val Lys Ser Gln Ser Ser Arg Ile Asn 1115 1120 1125 Phe Cys Gly Asn Gly Asn His Ile Leu Ser Leu Val Gln Asn Ala 1130 1135 1140 Pro Tyr Gly Leu Tyr Phe Ile His Phe Ser Tyr Val Pro Thr Ser 1145 1150 1155 Phe Thr Thr Ala Asn Val Ser Pro Gly Leu Cys Ile Ser Gly Asp 1160 1165 1170 Arg Gly Leu Ala Pro Lys Ala Gly Tyr Phe Val Gln Asp Asp Gly 1175 1180 1185 Glu Trp Lys Phe Thr Gly Ser Asn Tyr Tyr Tyr Pro Glu Pro Ile 1190 1195 1200 Thr Asp Lys Asn Ser Val Val Met Ser Ser Cys Ala Ala Asn Tyr 1205 1210 1215 Thr Lys Ala Pro Glu Val Phe Leu Asn Thr Ser Ile Pro Asn Leu 1220 1225 1230 Pro Asp Phe Lys Glu Glu Leu Asp Lys Trp Phe Lys Asn Gln Thr 1235 1240 1245 Ser Ile Ala Pro Asp Leu Ser Leu Asp Phe Glu Lys Leu Asn Val 1250 1255 1260 Thr Leu Leu Asp Leu Thr Asp Glu Met Asn Arg Ile Gln Asp Ala 1265 1270 1275 Ile Lys Lys Leu Asn Glu Ser Tyr Ile Asn Leu Lys Asp Val Gly 1280 1285 1290 Thr Tyr Glu Met Tyr Val Lys Trp Pro Trp Tyr Val Trp Leu Leu 1295 1300 1305 Ile Gly Leu Ala Gly Val Ala Val Cys Val Leu Leu Phe Phe Ile 1310 1315 1320 Cys Cys Cys Thr Gly Cys Gly Ser Cys Cys Phe Lys Lys Cys Gly 1325 1330 1335 Asn Cys Cys Asp Glu Cys Gly Gly His Gln Asp Ser Ile Val Ile 1340 1345 1350 His Asn Ile Ser Ser His Glu Asp 1355 1360 <210> 37 <211> 1361 <212> PRT <213> human coronavirus OC43 <220> <221> MISC_FEATURE <223> spike protein <400> 37 Met Phe Leu Ile Leu Leu Ile Ser Leu Pro Thr Ala Phe Ala Val Ile 1 5 10 15 Gly Asp Leu Lys Cys Thr Ser Asp Thr Ser Tyr Ile Asn Asp Lys Asp 20 25 30 Thr Gly Pro Pro Pro Ile Ser Thr Asp Thr Val Asp Val Thr Asn Gly 35 40 45 Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr Leu 50 55 60 Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn Met 65 70 75 80 Ala Leu Lys Gly Ser Val Leu Leu Ser Arg Leu Trp Phe Lys Pro Pro 85 90 95 Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn Thr 100 105 110 Lys Val Ile Lys Asp Arg Val Met Tyr Ser Glu Phe Pro Ala Ile Thr 115 120 125 Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln Pro 130 135 140 Arg Thr Ile Asn Ser Thr Gln Asp Gly Tyr Asn Lys Leu Gln Gly Leu 145 150 155 160 Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro Gln Thr 165 170 175 Ile Cys His Pro Asn Leu Gly Asn His Arg Lys Glu Leu Trp His Leu 180 185 190 Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr Asp 195 200 205 Val Asn Ala Asp Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly Thr 210 215 220 Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Val Val Thr Lys Phe Leu Phe 225 230 235 240 Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro Leu 245 250 255 Thr Cys Asn Ser Lys Val Lys Asn Gly Phe Thr Leu Glu Tyr Trp Val 260 265 270 Thr Pro Leu Thr Ser Arg Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly 275 280 285 Ile Ile Phe Asn Ala Val Asp Cys Met Ser Asp Phe Met Ser Glu Ile 290 295 300 Lys Cys Lys Thr Gln Ser Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu 305 310 315 320 Asn Gly Tyr Thr Val Gln Pro Ile Ala Asp Val Tyr Arg Arg Lys Leu 325 330 335 Asn Leu Pro Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp Lys Ser Val 340 345 350 Pro Ser Pro Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe 355 360 365 Asn Met Ser Ser Leu Met Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys 370 375 380 Asn Asn Ile Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile 385 390 395 400 Thr Ile Asp Lys Phe Ala Ile Pro Asn Gly Arg Lys Val Asp Leu Gln 405 410 415 Leu Gly Asn Leu Gly Tyr Leu Gln Ser Phe Asn Tyr Arg Ile Asp Thr 420 425 430 Thr Ala Thr Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val 435 440 445 Ser Val Ser Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe 450 455 460 Ile Glu Asp Ser Val Phe Lys Pro Arg Pro Ala Gly Val Leu Thr Asn 465 470 475 480 His Asp Val Val Tyr Ala Gln His Cys Phe Lys Ala Pro Lys Asn Phe 485 490 495 Cys Pro Cys Lys Leu Asn Gly Ser Cys Val Gly Ser Gly Pro Gly Lys 500 505 510 Asn Asn Gly Ile Gly Thr Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys 515 520 525 Asp Asn Leu Cys Thr Pro Asp Pro Ile Thr Phe Lys Ala Thr Gly Thr 530 535 540 Tyr Lys Cys Pro Gln Thr Lys Ser Leu Val Gly Ile Gly Glu His Cys 545 550 555 560 Ser Gly Leu Ala Val Lys Ser Asp Tyr Cys Gly Gly Asn Ser Cys Thr 565 570 575 Cys Arg Pro Gln Ala Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln 580 585 590 Gly Asp Lys Cys Asn Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn 595 600 605 Ser Gly Leu Thr Cys Ser Thr Asp Leu Gln Lys Ala Asn Thr Asp Ile 610 615 620 Ile Leu Gly Val Cys Val Asn Tyr Asp Leu Tyr Gly Ile Leu Gly Gln 625 630 635 640 Gly Ile Phe Val Glu Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn 645 650 655 Leu Leu Tyr Asp Ser Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile 660 665 670 Thr Asn Arg Thr Phe Met Ile Arg Ser Cys Tyr Ser Gly Arg Val Ser 675 680 685 Ala Ala Phe His Ala Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn 690 695 700 Ile Lys Cys Asn Tyr Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln 705 710 715 720 Pro Ile Asn Tyr Phe Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Tyr 725 730 735 Asn Ser Thr Ala Ile Ser Val Gln Thr Cys Asp Leu Thr Val Gly Ser 740 745 750 Gly Tyr Cys Val Asp Tyr Ser Lys Asn Arg Arg Ser Arg Gly Ala Ile 755 760 765 Thr Thr Gly Tyr Arg Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser 770 775 780 Val Asn Asp Ser Leu Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile 785 790 795 800 Pro Ser Glu Phe Thr Ile Gly Asn Met Glu Glu Phe Ile Gln Thr Ser 805 810 815 Ser Pro Lys Val Thr Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr 820 825 830 Ala Ala Cys Lys Ser Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn 835 840 845 Ile Asn Ala Ile Leu Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln 850 855 860 Leu Gln Val Ala Asn Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys 865 870 875 880 Leu Lys Asp Gly Val Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro 885 890 895 Val Leu Gly Cys Leu Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser 900 905 910 Ala Ile Glu Asp Leu Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly 915 920 925 Phe Val Glu Ala Tyr Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp 930 935 940 Leu Ile Cys Val Gln Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu 945 950 955 960 Leu Ser Glu Asn Gln Ile Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala 965 970 975 Ser Leu Phe Pro Leu Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr Leu 980 985 990 Asn Val Gln Tyr Arg Ile Asn Gly Leu Gly Val Thr Met Asp Val Leu 995 1000 1005 Ser Gln Asn Gln Lys Leu Ile Ala Asn Ala Phe Asn Asn Ala Leu 1010 1015 1020 Tyr Ala Ile Gln Glu Gly Phe Asp Ala Thr Asn Ser Ala Leu Val 1025 1030 1035 Lys Ile Gln Ala Val Val Asn Ala Asn Ala Glu Ala Leu Asn Asn 1040 1045 1050 Leu Leu Gln Gln Leu Ser Asn Arg Phe Gly Ala Ile Ser Ala Ser 1055 1060 1065 Leu Gln Glu Ile Leu Ser Arg Leu Asp Ala Leu Glu Ala Glu Ala 1070 1075 1080 Gln Ile Asp Arg Leu Ile Asn Gly Arg Leu Thr Ala Leu Asn Ala 1085 1090 1095 Tyr Val Ser Gln Gln Leu Ser Asp Ser Thr Leu Val Lys Phe Ser 1100 1105 1110 Ala Ala Gln Ala Met Glu Lys Val Asn Glu Cys Val Lys Ser Gln 1115 1120 1125 Ser Ser Arg Ile Asn Phe Cys Gly Asn Gly Asn His Ile Ile Ser 1130 1135 1140 Leu Val Gln Asn Ala Pro Tyr Gly Leu Tyr Phe Ile His Phe Ser 1145 1150 1155 Tyr Val Pro Thr Lys Tyr Val Thr Ala Arg Val Ser Pro Gly Leu 1160 1165 1170 Cys Ile Ala Gly Asp Arg Gly Ile Ala Pro Lys Ser Gly Tyr Phe 1175 1180 1185 Val Asn Val Asn Asn Thr Trp Met Tyr Thr Gly Ser Gly Tyr Tyr 1190 1195 1200 Tyr Pro Glu Pro Ile Thr Glu Asn Asn Val Val Val Met Ser Thr 1205 1210 1215 Cys Ala Val Asn Tyr Thr Lys Ala Pro Tyr Val Met Leu Asn Thr 1220 1225 1230 Ser Ile Pro Asn Leu Pro Asp Phe Lys Glu Glu Leu Asp Gln Trp 1235 1240 1245 Phe Lys Asn Gln Thr Ser Val Ala Pro Asp Leu Ser Leu Asp Tyr 1250 1255 1260 Ile Asn Val Thr Phe Leu Asp Leu Gln Val Glu Met Asn Arg Leu 1265 1270 1275 Gln Glu Ala Ile Lys Val Leu Asn Gln Ser Tyr Ile Asn Leu Lys 1280 1285 1290 Asp Ile Gly Thr Tyr Glu Tyr Tyr Val Lys Trp Pro Trp Tyr Val 1295 1300 1305 Trp Leu Leu Ile Cys Leu Ala Gly Val Ala Met Leu Val Leu Leu 1310 1315 1320 Phe Phe Ile Cys Cys Cys Thr Gly Cys Gly Thr Ser Cys Phe Lys 1325 1330 1335 Lys Cys Gly Gly Cys Cys Asp Asp Tyr Thr Gly Tyr Gln Glu Leu 1340 1345 1350 Val Ile Lys Thr Ser His Asp Asp 1355 1360 <210> 38 <211> 1383 <212> PRT <213> porcine epidemic diarhhea virus <220> <221> MISC_FEATURE <223> spike protein <400> 38 Met Arg Ser Leu Ile Tyr Phe Trp Leu Leu Leu Pro Val Leu Pro Thr 1 5 10 15 Leu Ser Leu Pro Gln Asp Val Thr Arg Cys Gln Ser Thr Thr Asn Phe 20 25 30 Arg Arg Phe Phe Ser Lys Phe Asn Val Gln Ala Pro Ala Val Val Val 35 40 45 Leu Gly Gly Tyr Leu Pro Ser Met Asn Ser Ser Ser Trp Tyr Cys Gly 50 55 60 Thr Gly Ile Glu Thr Ala Ser Gly Val His Gly Ile Phe Leu Ser Tyr 65 70 75 80 Ile Asp Ser Gly Gln Gly Phe Glu Ile Gly Ile Ser Gln Glu Pro Phe 85 90 95 Asp Pro Ser Gly Tyr Gln Leu Tyr Leu His Lys Ala Thr Asn Gly Asn 100 105 110 Thr Asn Ala Ile Ala Arg Leu Arg Ile Cys Gln Phe Pro Asp Asn Lys 115 120 125 Thr Leu Gly Pro Thr Val Asn Asp Val Thr Thr Gly Arg Asn Cys Leu 130 135 140 Phe Asn Lys Ala Ile Pro Ala Tyr Met Arg Asp Gly Lys Asp Ile Val 145 150 155 160 Val Gly Ile Thr Trp Asp Asn Asp Arg Val Thr Val Phe Ala Asp Lys 165 170 175 Ile Tyr His Phe Tyr Leu Lys Asn Asp Trp Ser Arg Val Ala Thr Arg 180 185 190 Cys Tyr Asn Arg Arg Ser Cys Ala Met Gln Tyr Val Tyr Thr Pro Thr 195 200 205 Tyr Tyr Met Leu Asn Val Thr Ser Ala Gly Glu Asp Gly Ile Tyr Tyr 210 215 220 Glu Pro Cys Thr Ala Asn Cys Thr Gly Tyr Ala Ala Asn Val Phe Ala 225 230 235 240 Thr Asp Ser Asn Gly His Ile Pro Glu Gly Phe Ser Phe Asn Asn Trp 245 250 255 Phe Leu Leu Ser Asn Asp Ser Thr Leu Leu His Gly Lys Val Val Ser 260 265 270 Asn Gln Pro Leu Leu Val Asn Cys Leu Leu Ala Ile Pro Lys Ile Tyr 275 280 285 Gly Leu Gly Gln Phe Phe Ser Phe Asn His Thr Met Asp Gly Val Cys 290 295 300 Asn Gly Ala Ala Val Asp Arg Ala Pro Glu Ala Leu Arg Phe Asn Ile 305 310 315 320 Asn Asp Thr Ser Val Ile Leu Ala Glu Gly Ser Ile Val Leu His Thr 325 330 335 Ala Leu Gly Thr Asn Leu Ser Phe Val Cys Ser Asn Ser Ser Asp Pro 340 345 350 His Leu Ala Ile Phe Ala Ile Pro Leu Gly Ala Thr Glu Val Pro Tyr 355 360 365 Tyr Cys Phe Leu Lys Val Asp Thr Tyr Asn Ser Thr Val Tyr Lys Phe 370 375 380 Leu Ala Val Leu Pro Pro Thr Val Arg Glu Ile Val Ile Thr Lys Tyr 385 390 395 400 Gly Asp Val Tyr Val Asn Gly Phe Gly Tyr Leu His Leu Gly Leu Leu 405 410 415 Asp Ala Val Thr Ile Asn Phe Thr Gly His Gly Thr Asp Asp Asp Val 420 425 430 Ser Gly Phe Trp Thr Ile Ala Ser Thr Asn Phe Val Asp Ala Leu Ile 435 440 445 Glu Val Gln Gly Thr Ser Ile Gln Arg Ile Leu Tyr Cys Asp Asp Pro 450 455 460 Val Ser Gln Leu Lys Cys Ser Gln Val Ala Phe Asp Leu Asp Asp Gly 465 470 475 480 Phe Tyr Pro Ile Ser Ser Arg Asn Leu Leu Ser His Glu Gln Pro Ile 485 490 495 Ser Phe Val Thr Leu Pro Ser Phe Asn Asp His Ser Phe Val Asn Ile 500 505 510 Thr Val Ser Ala Ala Phe Gly Gly Leu Ser Ser Ala Asn Leu Val Ala 515 520 525 Ser Asp Thr Thr Ile Asn Gly Phe Ser Ser Phe Cys Val Asp Thr Arg 530 535 540 Gln Phe Thr Ile Thr Leu Phe Tyr Asn Val Thr Asn Ser Tyr Gly Tyr 545 550 555 560 Val Ser Lys Ser Gln Asp Ser Asn Cys Pro Phe Thr Leu Gln Ser Val 565 570 575 Asn Asp Tyr Leu Ser Phe Ser Lys Phe Cys Val Ser Thr Ser Leu Leu 580 585 590 Ala Gly Ala Cys Thr Ile Asp Leu Phe Gly Tyr Pro Ala Phe Gly Ser 595 600 605 Gly Val Lys Leu Thr Ser Leu Tyr Phe Gln Phe Thr Lys Gly Glu Leu 610 615 620 Ile Thr Gly Thr Pro Lys Pro Leu Glu Gly Ile Thr Asp Val Ser Phe 625 630 635 640 Met Thr Leu Asp Val Cys Thr Lys Tyr Thr Ile Tyr Gly Phe Lys Gly 645 650 655 Glu Gly Ile Ile Thr Leu Thr Asn Ser Ser Ile Leu Ala Gly Val Tyr 660 665 670 Tyr Thr Ser Asp Ser Gly Gln Leu Leu Ala Phe Lys Asn Val Thr Ser 675 680 685 Gly Ala Val Tyr Ser Val Thr Pro Cys Ser Phe Ser Glu Gln Ala Ala 690 695 700 Tyr Val Asn Asp Asp Ile Val Gly Val Ile Ser Ser Leu Ser Asn Ser 705 710 715 720 Thr Phe Asn Asn Thr Arg Glu Leu Pro Gly Phe Phe Tyr His Ser Asn 725 730 735 Asp Gly Ser Asn Cys Thr Glu Pro Val Leu Val Tyr Ser Asn Ile Gly 740 745 750 Val Cys Lys Ser Gly Ser Ile Gly Tyr Val Pro Ser Gln Tyr Gly Gln 755 760 765 Val Lys Ile Ala Pro Thr Val Thr Gly Asn Ile Ser Ile Pro Thr Asn 770 775 780 Phe Ser Met Ser Ile Arg Thr Glu Tyr Leu Gln Leu Tyr Asn Thr Pro 785 790 795 800 Val Ser Val Asp Cys Ala Thr Tyr Val Cys Asn Gly Asn Ser Arg Cys 805 810 815 Lys Gln Leu Leu Thr Gln Tyr Thr Ala Ala Cys Lys Thr Ile Glu Ser 820 825 830 Ala Leu Gln Leu Ser Ala Arg Leu Glu Ser Val Glu Val Asn Ser Met 835 840 845 Leu Thr Ile Ser Glu Glu Ala Leu Gln Leu Ala Thr Ile Ser Ser Phe 850 855 860 Asn Gly Asp Gly Tyr Asn Phe Thr Asn Val Leu Gly Ala Ser Val Tyr 865 870 875 880 Asp Pro Ala Ser Gly Arg Val Val Gln Lys Arg Ser Val Ile Glu Asp 885 890 895 Leu Leu Phe Asn Lys Val Val Thr Asn Gly Leu Gly Thr Val Asp Glu 900 905 910 Asp Tyr Lys Arg Cys Ser Asn Gly Arg Ser Val Ala Asp Leu Val Cys 915 920 925 Ala Gln Tyr Tyr Ser Gly Val Met Val Leu Pro Gly Val Val Asp Ala 930 935 940 Glu Lys Leu His Met Tyr Ser Ala Ser Leu Ile Gly Gly Met Ala Leu 945 950 955 960 Gly Gly Ile Thr Ala Ala Ala Ala Leu Pro Phe Ser Tyr Ala Val Gln 965 970 975 Ala Arg Leu Asn Tyr Leu Ala Leu Gln Thr Asp Val Leu Gln Arg Asn 980 985 990 Gln Gln Leu Leu Ala Glu Ser Phe Asn Ser Ala Ile Gly Asn Ile Thr 995 1000 1005 Ser Ala Phe Glu Ser Val Lys Glu Ala Ile Ser Gln Thr Ser Lys 1010 1015 1020 Gly Leu Asn Thr Val Ala His Ala Leu Thr Lys Val Gln Glu Val 1025 1030 1035 Val Asn Ser Gln Gly Ser Ala Leu Asn Gln Leu Thr Val Gln Leu 1040 1045 1050 Gln His Asn Phe Gln Ala Ile Ser Ser Ser Ile Asp Asp Ile Tyr 1055 1060 1065 Ser Arg Leu Asp Ile Leu Ser Ala Asp Val Gln Val Asp Arg Leu 1070 1075 1080 Ile Thr Gly Arg Leu Ser Ala Leu Asn Ala Phe Val Ala Gln Thr 1085 1090 1095 Leu Thr Lys Tyr Thr Glu Val Gln Ala Ser Arg Lys Leu Ala Gln 1100 1105 1110 Gln Lys Val Asn Glu Cys Val Lys Ser Gln Ser Gln Arg Tyr Gly 1115 1120 1125 Phe Cys Gly Gly Asp Gly Glu His Ile Phe Ser Leu Val Gln Ala 1130 1135 1140 Ala Pro Gln Gly Leu Leu Phe Leu His Thr Val Leu Val Pro Gly 1145 1150 1155 Asp Phe Val Asn Val Leu Ala Ile Ala Gly Leu Cys Val Asn Gly 1160 1165 1170 Glu Ile Ala Leu Thr Leu Arg Glu Pro Gly Leu Val Leu Phe Thr 1175 1180 1185 His Glu Leu Gln Thr Tyr Thr Ala Thr Glu Tyr Phe Val Ser Ser 1190 1195 1200 Arg Arg Met Phe Glu Pro Arg Lys Pro Thr Val Ser Asp Phe Val 1205 1210 1215 Gln Ile Glu Ser Cys Val Val Thr Tyr Val Asn Leu Thr Ser Asp 1220 1225 1230 Gln Leu Pro Asp Val Ile Pro Asp Tyr Ile Asp Val Asn Lys Thr 1235 1240 1245 Leu Asp Glu Ile Leu Ala Ser Leu Pro Asn Arg Thr Gly Pro Ser 1250 1255 1260 Leu Pro Leu Asp Val Phe Asn Ala Thr Tyr Leu Asn Leu Thr Gly 1265 1270 1275 Glu Ile Ala Asp Leu Glu Gln Arg Ser Glu Ser Leu Arg Asn Thr 1280 1285 1290 Thr Glu Glu Leu Arg Ser Leu Ile Asn Asn Ile Asn Asn Thr Leu 1295 1300 1305 Val Asp Leu Glu Trp Leu Asn Arg Val Glu Thr Tyr Ile Lys Trp 1310 1315 1320 Pro Trp Trp Val Trp Leu Ile Ile Val Ile Val Leu Ile Phe Val 1325 1330 1335 Val Ser Leu Leu Val Phe Cys Cys Ile Ser Thr Gly Cys Cys Gly 1340 1345 1350 Cys Cys Gly Cys Cys Gly Ala Cys Phe Ser Gly Cys Cys Arg Gly 1355 1360 1365 Pro Arg Leu Gln Pro Tyr Glu Ala Phe Glu Lys Val His Val Gln 1370 1375 1380 <210> 39 <211> 1349 <212> PRT <213> porcine haemagglutinating encephalomyelitis virus <220> <221> MISC_FEATURE <223> spike protein <400> 39 Met Phe Phe Ile Leu Leu Ile Ser Leu Pro Ser Ala Phe Ala Val Ile 1 5 10 15 Gly Asp Leu Lys Cys Thr Thr Ser Leu Ile Asn Asp Val Asp Thr Gly 20 25 30 Val Pro Ser Ile Ser Ser Glu Val Val Asp Val Thr Asn Gly Leu Gly 35 40 45 Thr Phe Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr Leu Leu Leu 50 55 60 Asn Gly Tyr Tyr Pro Ile Ser Gly Ala Thr Phe Arg Asn Met Ala Leu 65 70 75 80 Lys Gly Thr Arg Leu Leu Ser Thr Leu Trp Phe Lys Pro Pro Phe Leu 85 90 95 Ser Pro Phe Asn Asp Gly Ile Phe Ala Lys Val Lys Asn Ser Arg Phe 100 105 110 Ser Lys Asp Gly Val Ile Tyr Ser Glu Phe Pro Ala Ile Thr Ile Gly 115 120 125 Ser Thr Phe Val Asn Thr Ser Tyr Ser Ile Val Val Glu Pro His Thr 130 135 140 Ser Leu Ile Asn Gly Asn Leu Gln Gly Leu Leu Gln Ile Ser Val Cys 145 150 155 160 Gln Tyr Thr Met Cys Glu Tyr Pro His Thr Ile Cys His Pro Asn Leu 165 170 175 Gly Asn Gln Arg Ile Glu Leu Trp His Tyr Asp Thr Asp Val Val Ser 180 185 190 Cys Leu Tyr Arg Arg Asn Phe Thr Tyr Asp Val Asn Ala Asp Tyr Leu 195 200 205 Tyr Phe His Phe Tyr Gln Glu Gly Gly Thr Phe Tyr Ala Tyr Phe Thr 210 215 220 Asp Thr Gly Phe Val Thr Lys Phe Leu Phe Lys Leu Tyr Leu Gly Thr 225 230 235 240 Val Leu Ser His Tyr Tyr Val Met Pro Leu Thr Cys Asn Ser Ala Leu 245 250 255 Ser Leu Glu Tyr Trp Val Thr Pro Leu Thr Thr Arg Gln Phe Leu Leu 260 265 270 Ala Phe Asp Gln Asp Gly Val Leu Tyr His Ala Val Asp Cys Ala Ser 275 280 285 Asp Phe Met Ser Glu Ile Met Cys Lys Thr Ser Ser Ile Thr Pro Pro 290 295 300 Thr Gly Val Tyr Glu Leu Asn Gly Tyr Thr Val Gln Pro Val Ala Thr 305 310 315 320 Val Tyr Arg Arg Ile Pro Asp Leu Pro Asn Cys Asp Ile Glu Ala Trp 325 330 335 Leu Asn Ser Lys Thr Val Ser Ser Pro Leu Asn Trp Glu Arg Lys Ile 340 345 350 Phe Ser Asn Cys Asn Phe Asn Met Gly Arg Leu Met Ser Phe Ile Gln 355 360 365 Ala Asp Ser Phe Gly Cys Asn Asn Ile Asp Ala Ser Arg Leu Tyr Gly 370 375 380 Met Cys Phe Gly Ser Ile Thr Ile Asp Lys Phe Ala Ile Pro Asn Ser 385 390 395 400 Arg Lys Val Asp Leu Gln Val Gly Lys Ser Gly Tyr Leu Gln Ser Phe 405 410 415 Asn Tyr Lys Ile Asp Thr Ala Val Ser Ser Cys Gln Leu Tyr Tyr Ser 420 425 430 Leu Pro Ala Ala Asn Val Ser Val Thr His Tyr Asn Pro Ser Ser Trp 435 440 445 Asn Arg Arg Tyr Gly Phe Asn Asn Gln Ser Phe Gly Ser Arg Gly Leu 450 455 460 His Asp Ala Val Tyr Ser Gln Gln Cys Phe Asn Thr Pro Asn Thr Tyr 465 470 475 480 Cys Pro Cys Arg Thr Ser Gln Cys Ile Gly Gly Ala Gly Thr Gly Thr 485 490 495 Cys Pro Val Gly Thr Thr Val Arg Lys Cys Phe Ala Ala Val Thr Lys 500 505 510 Ala Thr Lys Cys Thr Cys Trp Cys Gln Pro Asp Pro Ser Thr Tyr Lys 515 520 525 Gly Val Asn Ala Trp Thr Cys Pro Gln Ser Lys Val Ser Ile Gln Pro 530 535 540 Gly Gln His Cys Pro Gly Leu Gly Leu Val Glu Asp Asp Cys Ser Gly 545 550 555 560 Asn Pro Cys Thr Cys Lys Pro Gln Ala Phe Ile Gly Trp Ser Ser Glu 565 570 575 Thr Cys Leu Gln Asn Gly Arg Cys Asn Ile Phe Ala Asn Phe Ile Leu 580 585 590 Asn Asp Val Asn Ser Gly Thr Thr Cys Ser Thr Asp Leu Gln Gln Gly 595 600 605 Asn Thr Ile Ile Thr Thr Asp Val Cys Val Asn Tyr Asp Leu Tyr Gly 610 615 620 Ile Thr Gly Gln Gly Ile Leu Ile Glu Val Asn Ala Thr Tyr Tyr Asn 625 630 635 640 Ser Trp Gln Asn Leu Leu Tyr Asp Ser Ser Gly Asn Leu Tyr Gly Phe 645 650 655 Arg Asp Tyr Leu Ser Asn Arg Thr Phe Leu Ile Arg Ser Cys Tyr Ser 660 665 670 Gly Arg Val Ser Ala Val Phe His Ala Asn Ser Ser Glu Pro Ala Leu 675 680 685 Met Phe Arg Asn Leu Lys Cys Ser His Val Phe Asn Asn Thr Ile Leu 690 695 700 Arg Gln Ile Gln Leu Val Asn Tyr Phe Asp Ser Tyr Leu Gly Cys Val 705 710 715 720 Val Asn Ala Tyr Asn Asn Thr Ala Ser Ala Val Ser Thr Cys Asp Leu 725 730 735 Thr Val Gly Ser Gly Tyr Cys Val Asp Tyr Val Thr Ala Leu Arg Ser 740 745 750 Arg Arg Ser Phe Thr Thr Gly Tyr Arg Phe Thr Asn Phe Glu Pro Phe 755 760 765 Ala Ala Asn Leu Val Asn Asp Ser Ile Glu Pro Val Gly Gly Leu Tyr 770 775 780 Glu Ile Gln Ile Pro Ser Glu Phe Thr Ile Gly Asn Leu Glu Glu Phe 785 790 795 800 Ile Gln Thr Arg Ser Pro Lys Val Thr Ile Asp Cys Ala Thr Phe Val 805 810 815 Cys Gly Asp Tyr Ala Ala Cys Arg Gln Gln Leu Ala Glu Tyr Gly Ser 820 825 830 Phe Cys Glu Asn Ile Asn Ala Ile Leu Thr Glu Val Asn Glu Leu Leu 835 840 845 Asp Thr Thr Gln Leu Gln Val Ala Asn Ser Leu Met Asn Gly Val Thr 850 855 860 Leu Ser Thr Lys Ile Lys Asp Gly Ile Asn Phe Asn Val Asp Asp Ile 865 870 875 880 Asn Phe Ser Pro Val Leu Gly Cys Leu Gly Ser Glu Cys Asn Arg Ala 885 890 895 Ser Thr Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp Lys Val Lys Leu 900 905 910 Ser Asp Val Gly Phe Val Gln Ala Tyr Asn Asn Cys Thr Gly Gly Ala 915 920 925 Glu Ile Arg Asp Leu Ile Cys Val Gln Ser Tyr Asn Gly Ile Lys Val 930 935 940 Leu Pro Pro Leu Leu Ser Glu Asn Gln Ile Ser Gly Tyr Thr Leu Ala 945 950 955 960 Ala Thr Ala Ala Ser Leu Phe Pro Pro Trp Thr Ala Ala Ala Gly Val 965 970 975 Pro Phe Tyr Leu Asn Val Gln Tyr Arg Ile Asn Gly Leu Gly Val Thr 980 985 990 Met Asp Val Leu Ser Gln Asn Gln Lys Leu Ile Ala Ser Ala Phe Asn 995 1000 1005 Asn Ala Leu Asp Ala Ile Gln Glu Gly Phe Asp Ala Thr Asn Ser 1010 1015 1020 Ala Leu Val Lys Ile Gln Ala Val Val Asn Ala Asn Ala Glu Ala 1025 1030 1035 Leu Asn Asn Leu Leu Gln Gln Leu Ser Asn Arg Phe Gly Ala Ile 1040 1045 1050 Ser Ala Ser Leu Gln Glu Ile Leu Ser Arg Leu Asp Ala Leu Glu 1055 1060 1065 Ala Lys Ala Gln Ile Asp Arg Leu Ile Asn Gly Arg Leu Thr Ala 1070 1075 1080 Leu Asn Ala Tyr Val Ser Gln Gln Leu Ser Asp Ser Thr Leu Val 1085 1090 1095 Lys Phe Ser Ala Ala Gln Ala Ile Glu Lys Val Asn Glu Cys Val 1100 1105 1110 Lys Ser Gln Ser Ser Arg Ile Asn Phe Cys Gly Asn Gly Asn His 1115 1120 1125 Ile Ile Ser Leu Val Gln Asn Ala Pro Tyr Gly Leu Tyr Phe Ile 1130 1135 1140 His Phe Ser Tyr Val Pro Thr Lys Tyr Val Thr Ala Lys Val Ser 1145 1150 1155 Pro Gly Leu Cys Ile Ala Gly Asp Ile Gly Ile Ser Pro Lys Ser 1160 1165 1170 Gly Tyr Phe Ile Asn Val Asn Asn Ser Trp Met Phe Thr Gly Ser 1175 1180 1185 Ser Tyr Tyr Tyr Pro Glu Pro Ile Thr Gln Asn Asn Val Val Val 1190 1195 1200 Met Ser Thr Cys Ala Val Asn Tyr Thr Lys Ala Pro Asp Leu Met 1205 1210 1215 Leu Asn Thr Ser Thr Pro Asn Leu Pro Asp Phe Lys Glu Glu Leu 1220 1225 1230 Tyr Gln Trp Phe Lys Asn Gln Ser Ser Val Ala Pro Asp Leu Ser 1235 1240 1245 Leu Asp Tyr Ile Asn Val Thr Phe Leu Asp Leu Gln Asp Glu Met 1250 1255 1260 Asn Arg Leu Gln Glu Ala Ile Lys Val Leu Asn Gln Ser Tyr Ile 1265 1270 1275 Asn Leu Lys Asp Ile Gly Thr Tyr Glu Tyr Tyr Val Lys Trp Pro 1280 1285 1290 Trp Tyr Val Trp Leu Leu Ile Gly Leu Ala Gly Val Ala Met Leu 1295 1300 1305 Val Leu Leu Phe Phe Ile Cys Cys Cys Thr Gly Cys Gly Thr Ser 1310 1315 1320 Cys Phe Lys Lys Cys Gly Gly Cys Cys Asp Asp Tyr Thr Gly His 1325 1330 1335 Gln Glu Phe Val Ile Lys Thr Ser His Asp Asp 1340 1345 <210> 40 <211> 1225 <212> PRT <213> porcine respiratory coronavirus <220> <221> MISC_FEATURE <223> spike protein <400> 40 Met Lys Lys Leu Phe Val Val Leu Val Val Met Pro Leu Ile Tyr Gly 1 5 10 15 Asp Lys Phe Pro Thr Ser Val Val Ser Asn Cys Thr Asp Gln Cys Ala 20 25 30 Ser Tyr Val Ala Asn Val Phe Thr Ile Leu Pro Gly Gly Phe Ile Pro 35 40 45 Ser Asp Phe Ser Phe Asn Asn Trp Phe Leu Leu Thr Asn Ser Ser Thr 50 55 60 Leu Val Asn Gly Lys Leu Val Thr Lys Gln Pro Leu Leu Val Asn Cys 65 70 75 80 Leu Trp Pro Val Pro Ser Phe Glu Glu Val Ala Ser Thr Phe Cys Phe 85 90 95 Glu Gly Ala Asp Phe Asp Gln Cys Asn Gly Ala Val Leu Asn Asn Thr 100 105 110 Val Asp Val Ile Arg Phe Asn Leu Asn Phe Thr Thr Asn Val Gln Ser 115 120 125 Gly Lys Gly Ala Thr Val Phe Ser Leu Asn Thr Thr Gly Gly Val Thr 130 135 140 Leu Glu Ile Ser Cys Tyr Asn Asp Thr Val Ser Asp Ser Ser Phe Ser 145 150 155 160 Ser Tyr Gly Glu Ile Pro Phe Gly Val Thr Asn Gly Pro Arg Tyr Cys 165 170 175 Tyr Val Leu Tyr Asn Gly Thr Ala Leu Lys Tyr Leu Gly Thr Leu Pro 180 185 190 Pro Ser Val Lys Glu Ile Ala Ile Ser Lys Trp Gly His Phe Tyr Ile 195 200 205 Asn Gly Tyr Asn Phe Phe Ser Thr Phe Pro Ile Asp Cys Ile Ser Phe 210 215 220 Asn Leu Thr Thr Gly Asp Ser Asp Val Phe Trp Thr Ile Ala Tyr Thr 225 230 235 240 Ser Tyr Thr Glu Ala Leu Val Gln Val Glu Asn Thr Ala Ile Thr Asn 245 250 255 Val Thr Tyr Cys Asn Ser Tyr Val Asn Asn Ile Lys Cys Ser Gln Leu 260 265 270 Thr Ala Asn Leu Asn Asn Gly Phe Tyr Pro Val Ser Ser Ser Glu Val 275 280 285 Gly Ser Val Asn Lys Ser Val Val Leu Leu Pro Ser Phe Leu Thr His 290 295 300 Thr Ile Val Asn Ile Thr Ile Gly Leu Gly Met Lys Arg Ser Gly Tyr 305 310 315 320 Gly Gln Pro Ile Ala Ser Thr Leu Ser Asn Ile Thr Leu Pro Met Gln 325 330 335 Asp Asn Asn Asn Asp Val Tyr Cys Val Arg Ser Asp Gln Phe Ser Val 340 345 350 Tyr Val His Ser Thr Cys Lys Ser Val Leu Trp Asp Asn Val Phe Lys 355 360 365 Arg Asn Cys Thr Asp Val Leu Asp Ala Thr Ala Val Ile Lys Thr Gly 370 375 380 Thr Cys Pro Phe Ser Phe Asp Lys Leu Asn Asn Tyr Leu Thr Phe Asn 385 390 395 400 Lys Phe Cys Leu Ser Leu Ser Pro Val Gly Ala Asn Cys Lys Phe Asp 405 410 415 Val Ala Ala Arg Thr Arg Thr Asn Asp Gln Val Val Arg Ser Leu Tyr 420 425 430 Val Ile Tyr Glu Glu Gly Asp Ser Ile Val Gly Val Pro Ser Asp Asn 435 440 445 Ser Gly Leu His Asp Leu Ser Val Leu His Leu Asp Ser Cys Thr Asp 450 455 460 Tyr Asn Ile Tyr Gly Arg Thr Gly Val Gly Ile Ile Arg Gln Thr Asn 465 470 475 480 Arg Thr Ile Leu Ser Gly Leu Tyr Tyr Thr Ser Leu Ser Gly Asp Leu 485 490 495 Leu Gly Phe Thr Asn Val Ser Asp Gly Val Ile Tyr Ser Val Thr Pro 500 505 510 Cys Asp Val Ser Ala Gln Ala Ala Ile Ile Asp Gly Thr Ile Val Gly 515 520 525 Ala Ile Thr Ser Ile Asn Ser Glu Leu Leu Gly Leu Thr His Trp Thr 530 535 540 Thr Thr Pro Asn Phe Tyr Tyr Tyr Ser Ile Tyr Asn Tyr Thr Asn Asp 545 550 555 560 Lys Thr Arg Gly Thr Pro Ile Gly Ser Asn Asp Val Asp Cys Glu Pro 565 570 575 Val Ile Thr Tyr Ser Asn Ile Gly Val Cys Lys Asn Gly Ala Leu Val 580 585 590 Phe Ile Asn Val Thr His Ser Asp Gly Asp Val Gln Pro Ile Ser Thr 595 600 605 Gly Asn Val Thr Ile Pro Thr Asn Phe Thr Ile Ser Val Gln Val Glu 610 615 620 Tyr Ile Gln Val Tyr Thr Thr Pro Val Ser Ile Asp Cys Ser Arg Tyr 625 630 635 640 Val Cys Asn Gly Asn Pro Arg Cys Asn Lys Leu Leu Thr Gln Tyr Val 645 650 655 Ser Ala Cys Gln Thr Ile Glu Gln Ala Leu Ala Met Gly Ala Arg Leu 660 665 670 Glu Asn Met Glu Val Asp Ser Met Leu Phe Val Ser Glu Asn Ala Leu 675 680 685 Lys Leu Ala Ser Val Glu Ala Phe Asn Ser Ser Glu Thr Leu Asp Pro 690 695 700 Ile Tyr Lys Glu Trp Pro Asn Ile Gly Gly Phe Trp Leu Glu Gly Leu 705 710 715 720 Lys Tyr Ile Leu Pro Ser Asp Asn Ser Lys Arg Lys Tyr Arg Ser Ala 725 730 735 Ile Glu Asp Leu Leu Phe Ser Lys Val Val Thr Ser Gly Leu Gly Thr 740 745 750 Val Asp Glu Asp Tyr Lys Arg Cys Thr Gly Gly Tyr Asp Ile Ala Asp 755 760 765 Leu Val Cys Ala Gln Tyr Tyr Asn Gly Ile Met Val Leu Pro Gly Val 770 775 780 Ala Asn Ala Asp Lys Met Thr Met Tyr Thr Ala Ser Leu Ala Gly Gly 785 790 795 800 Ile Thr Leu Gly Ala Leu Gly Gly Gly Ala Val Ala Ile Pro Phe Ala 805 810 815 Val Ala Val Gln Ala Arg Leu Asn Tyr Val Ala Leu Gln Thr Asp Val 820 825 830 Leu Asn Lys Asn Gln Gln Ile Leu Ala Ser Ala Phe Asn Gln Ala Ile 835 840 845 Gly Asn Ile Thr Gln Ser Phe Gly Lys Val Asn Asp Ala Ile His Gln 850 855 860 Thr Ser Arg Gly Leu Thr Thr Val Ala Lys Ala Leu Ala Lys Val Gln 865 870 875 880 Asp Val Val Asn Thr Gln Gly Gln Ala Leu Arg His Leu Thr Val Gln 885 890 895 Leu Gln Asn Asn Phe Gln Ala Ile Ser Ser Ser Ile Ser Asp Ile Tyr 900 905 910 Asn Arg Leu Asp Glu Leu Ser Ala Asp Ala Gln Val Asp Arg Leu Ile 915 920 925 Thr Gly Arg Leu Thr Ala Leu Asn Ala Phe Val Ser Gln Thr Leu Thr 930 935 940 Arg Gln Ala Glu Val Arg Ala Ser Arg Gln Leu Ala Lys Asp Lys Val 945 950 955 960 Asn Glu Cys Val Arg Ser Gln Ser Gln Arg Phe Gly Phe Cys Gly Asn 965 970 975 Gly Thr His Leu Phe Ser Leu Ala Asn Ala Ala Pro Asn Gly Met Ile 980 985 990 Phe Phe His Thr Val Leu Leu Pro Thr Ala Tyr Glu Thr Val Thr Ala 995 1000 1005 Trp Ser Gly Ile Cys Ala Leu Asp Val Asp Arg Thr Phe Gly Leu 1010 1015 1020 Val Val Lys Asp Val Gln Leu Thr Leu Phe Arg Asn Leu Asp Asp 1025 1030 1035 Lys Phe Tyr Leu Thr Pro Arg Thr Met Tyr Gln Pro Arg Val Ala 1040 1045 1050 Thr Ser Ser Asp Phe Val Gln Ile Glu Gly Cys Asp Val Leu Phe 1055 1060 1065 Val Asn Thr Thr Val Ser Asp Leu Pro Ser Ile Ile Pro Asp Tyr 1070 1075 1080 Ile Asp Ile Asn Gln Thr Val Gln Asp Ile Leu Glu Asn Phe Arg 1085 1090 1095 Pro Asn Trp Thr Val Pro Glu Leu Thr Leu Asp Val Phe Asn Ala 1100 1105 1110 Thr Tyr Leu Asn Leu Thr Gly Glu Ile Asp Asp Leu Glu Phe Arg 1115 1120 1125 Ser Glu Lys Leu His Asn Thr Thr Val Glu Leu Ala Ile Leu Ile 1130 1135 1140 Asp Asn Ile Asn Asn Thr Val Val Asn Leu Glu Trp Leu Asn Arg 1145 1150 1155 Ile Glu Thr Tyr Val Lys Trp Pro Trp Tyr Val Trp Leu Leu Ile 1160 1165 1170 Gly Leu Val Val Ile Phe Cys Ile Pro Leu Leu Leu Phe Cys Cys 1175 1180 1185 Cys Ser Thr Gly Cys Cys Gly Cys Ile Gly Cys Leu Gly Ser Cys 1190 1195 1200 Cys His Ser Ile Phe Ser Arg Arg Gln Phe Glu Asn Tyr Glu Pro 1205 1210 1215 Ile Glu Lys Val His Val His 1220 1225 <210> 41 <211> 1360 <212> PRT <213> rat coronavirus <220> <221> MISC_FEATURE <223> spike protein <400> 41 Met Leu Phe Val Phe Leu Thr Leu Leu Pro Ser Cys Leu Gly Tyr Ile 1 5 10 15 Gly Asp Phe Arg Cys Ile Asn Leu Val Asn Thr Arg Ile Ser Asn Ala 20 25 30 Arg Ala Pro Ser Val Ser Thr Glu Val Val Asp Val Ser Lys Gly Leu 35 40 45 Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Ala Thr Leu Leu 50 55 60 Leu Thr Gly Tyr Tyr Pro Val Asp Gly Ser Met Tyr Arg Asn Met Ala 65 70 75 80 Leu Met Gly Thr Asn Thr Leu Ser Leu Asn Trp Phe Glu Pro Pro Phe 85 90 95 Leu Ser Glu Phe Asn Asp Gly Ile Tyr Ala Lys Val Lys Asn Leu Lys 100 105 110 Ala Ser Leu Pro Ile Gly Ser Ala Ser Tyr Phe Pro Thr Ile Ile Ile 115 120 125 Gly Ser Asn Phe Val Asn Thr Ser Tyr Thr Val Val Leu Glu Pro Tyr 130 135 140 Asn Gly Ile Ile Met Ala Ser Ile Cys Gln Tyr Thr Ile Cys Gln Leu 145 150 155 160 Pro His Thr Asp Cys Lys Pro Asn Thr Gly Gly Asn Thr Leu Ile Gly 165 170 175 Phe Trp His Thr Asp Leu Arg Pro Pro Val Cys Ile Leu Lys Arg Asn 180 185 190 Phe Thr Phe Asn Val Asn Ala Glu Trp Leu Tyr Phe His Phe Tyr Gln 195 200 205 Gln Gly Gly Thr Phe Tyr Ala Tyr Tyr Ala Asp Val Ser Ser Ala Thr 210 215 220 Thr Phe Leu Phe Ser Ser Tyr Ile Gly Ala Val Leu Thr Gln Tyr Phe 225 230 235 240 Val Leu Pro Tyr Met Cys Ser Pro Thr Thr Ser Gly Val Ser Ser Pro 245 250 255 Gln Tyr Trp Val Thr Pro Leu Val Lys Arg Gln Tyr Leu Phe Asn Phe 260 265 270 Asn Gln Lys Gly Ile Ile Thr Ser Ala Val Asp Cys Ala Ser Ser Tyr 275 280 285 Thr Ser Glu Ile Lys Cys Lys Thr Gln Ser Met Asn Pro Asn Thr Gly 290 295 300 Val Tyr Asp Leu Ser Gly Tyr Thr Val Gln Pro Val Gly Leu Val Tyr 305 310 315 320 Arg Arg Val Arg Asn Leu Pro Asp Cys Lys Ile Glu Glu Trp Leu Ala 325 330 335 Ala Asn Thr Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Thr Phe Gln 340 345 350 Asn Cys Asn Phe Asn Leu Ser Ser Leu Leu Arg Phe Val Gln Ala Glu 355 360 365 Ser Leu Ser Cys Ser Asn Ile Asp Ala Ser Lys Val Tyr Gly Met Cys 370 375 380 Phe Gly Ser Ile Ser Ile Asp Lys Phe Ala Ile Pro Asn Ser Arg Arg 385 390 395 400 Val Asp Leu Gln Leu Gly Lys Ser Gly Leu Leu Gln Ser Phe Asn Tyr 405 410 415 Lys Ile Asp Thr Arg Ala Thr Ser Cys Gln Leu Tyr Tyr Ser Leu Ala 420 425 430 Gln Asp Asn Val Thr Val Ile Asn His Asn Pro Ser Ser Trp Asn Arg 435 440 445 Arg Tyr Gly Phe Asn Asp Val Ala Thr Phe His Ser Gly Glu His Asp 450 455 460 Val Ala Tyr Ala Glu Ala Cys Phe Thr Val Gly Ala Ser Tyr Cys Pro 465 470 475 480 Cys Ala Lys Pro Ser Thr Val Tyr Ser Cys Val Thr Gly Lys Pro Lys 485 490 495 Ser Ala Asn Cys Pro Thr Gly Thr Ser Asn Arg Glu Cys Asn Val Gln 500 505 510 Ala Ser Gly Phe Lys Ser Lys Cys Asp Cys Thr Cys Asn Pro Ser Pro 515 520 525 Leu Thr Thr Tyr Asp Pro Arg Cys Leu Gln Ala Arg Ser Met Leu Gly 530 535 540 Val Gly Asp His Cys Glu Gly Leu Gly Ile Leu Glu Asp Lys Cys Gly 545 550 555 560 Gly Ser Asn Ile Cys Asn Cys Ser Ala Asp Ala Phe Val Gly Trp Ala 565 570 575 Met Asp Ser Cys Leu Ser Asn Ala Arg Cys His Ile Phe Ser Asn Leu 580 585 590 Met Leu Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Thr Asp Phe Gln 595 600 605 Leu Pro Asn Thr Glu Val Val Thr Gly Val Cys Val Lys Tyr Asp Leu 610 615 620 Tyr Gly Ser Thr Gly Gln Gly Val Phe Lys Glu Val Lys Ala Asp Tyr 625 630 635 640 Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Val Asn Gly Asn Leu Asn 645 650 655 Gly Phe Arg Asp Ile Val Thr Asn Lys Thr Tyr Leu Leu Arg Ser Cys 660 665 670 Tyr Ser Gly Arg Val Ser Ala Ala Tyr His Gln Asp Ala Pro Glu Pro 675 680 685 Ala Leu Leu Tyr Arg Asn Leu Lys Cys Asp Tyr Val Phe Asn Asn Asn 690 695 700 Ile Ser Arg Glu Glu Thr Pro Leu Asn Tyr Phe Asp Ser Tyr Leu Gly 705 710 715 720 Cys Val Ile Asn Ala Asp Asn Ser Thr Glu Gln Ser Val Asp Ala Cys 725 730 735 Asp Leu Arg Met Gly Ser Gly Leu Cys Val Asn Tyr Ser Ile Ala His 740 745 750 Arg Ala Arg Arg Ser Val Ser Thr Gly Tyr Lys Leu Thr Thr Phe Glu 755 760 765 Pro Phe Thr Val Ser Ile Val Asn Asp Ser Val Glu Ser Val Gly Gly 770 775 780 Leu Tyr Glu Met Gln Ile Pro Thr Asn Phe Thr Ile Ala Ser His Gln 785 790 795 800 Glu Phe Ile Gln Thr Arg Ser Pro Lys Val Thr Ile Asp Cys Ala Ala 805 810 815 Phe Val Cys Gly Asp Tyr Thr Ala Cys Arg Gln Gln Leu Val Asp Tyr 820 825 830 Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu Gly Glu Val Asn Asn 835 840 845 Leu Ile Asp Thr Met Gln Leu Gln Val Ala Ser Ala Leu Ile Gln Gly 850 855 860 Val Thr Leu Ser Ser Arg Leu Ala Asp Gly Ile Ser Gly Gln Ile Asp 865 870 875 880 Asp Ile Asn Phe Ser Pro Leu Leu Gly Cys Leu Gly Ser Asp Cys Ser 885 890 895 Glu Gly Thr Lys Ala Ala Gln Gly Arg Ser Ala Ile Glu Asp Val Leu 900 905 910 Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ser Tyr Asn 915 920 925 Asn Cys Thr Gly Gly Gln Glu Val Arg Asp Leu Leu Cys Val Gln Ser 930 935 940 Phe Asn Gly Ile Lys Val Leu Pro Pro Val Leu Ser Glu Ser Gln Ile 945 950 955 960 Ser Gly Tyr Thr Ala Gly Ala Thr Ala Ser Ala Met Phe Pro Pro Trp 965 970 975 Ser Ala Ala Ala Gly Val Pro Phe Ala Leu Ser Val Gln Tyr Arg Ile 980 985 990 Asn Gly Leu Gly Val Thr Met Asn Val Leu Ser Glu Asn Gln Lys Met 995 1000 1005 Ile Ala Ser Ser Phe Asn Asn Ala Ile Gly Ala Ile Gln Glu Gly 1010 1015 1020 Phe Asp Ala Thr Asn Ser Ala Leu Ala Lys Ile Gln Ser Val Val 1025 1030 1035 Asn Ala Asn Ala Glu Ala Leu Asn Asn Leu Leu Asn Gln Leu Ser 1040 1045 1050 Asn Arg Phe Gly Ala Ile Ser Ala Ser Leu Gln Glu Ile Leu Ser 1055 1060 1065 Arg Leu Asp Ala Leu Glu Ala Gln Ala Gln Ile Asp Arg Leu Ile 1070 1075 1080 Asn Gly Arg Leu Thr Ala Leu Asn Ala Tyr Val Ser Lys Gln Leu 1085 1090 1095 Ser Asp Met Thr Leu Ile Lys Val Ser Ala Ala Gln Ala Ile Glu 1100 1105 1110 Lys Val Asn Glu Cys Val Lys Ser Gln Ser Pro Arg Ile Asn Phe 1115 1120 1125 Cys Gly Asn Gly Asn His Ile Leu Ser Leu Val Gln Asn Ala Pro 1130 1135 1140 Tyr Gly Leu Tyr Phe Ile His Phe Ser Tyr Val Pro Thr Ser Phe 1145 1150 1155 Thr Thr Val Asn Val Ser Pro Gly Leu Cys Ile Ser Gly Asp Arg 1160 1165 1170 Gly Leu Ala Pro Lys Ala Gly Tyr Phe Val Gln Asp His Gly Glu 1175 1180 1185 Trp Lys Phe Thr Gly Ser Asn Tyr Tyr Tyr Pro Glu Ser Ile Thr 1190 1195 1200 Asp Lys Asn Ser Val Val Met Ser Ser Cys Ala Val Asn Tyr Thr 1205 1210 1215 Lys Ala Pro Glu Val Phe Leu Asn Thr Ser Ile Thr Asn Leu Pro 1220 1225 1230 Asp Phe Lys Glu Glu Leu Asp Lys Trp Phe Lys Asn Gln Thr Ser 1235 1240 1245 Ile Val Pro Asp Leu Ser Phe Asp Ile Gly Lys Leu Asn Val Thr 1250 1255 1260 Phe Leu Asp Leu Ser Tyr Glu Met Asn Arg Ile Gln Asp Ala Ile 1265 1270 1275 Lys Asn Leu Asn Glu Ser Tyr Ile Asn Leu Lys Glu Ile Gly Thr 1280 1285 1290 Tyr Glu Met Tyr Val Lys Trp Pro Trp Tyr Val Trp Leu Leu Ile 1295 1300 1305 Gly Leu Ala Gly Val Ala Val Cys Val Leu Leu Phe Phe Ile Cys 1310 1315 1320 Cys Cys Thr Gly Cys Gly Ser Cys Cys Phe Lys Lys Cys Gly Asn 1325 1330 1335 Cys Cys Asp Glu Tyr Gly Gly Arg Gln Ala Gly Ile Val Ile His 1340 1345 1350 Asn Ile Ser Ser His Glu Asp 1355 1360 <210> 42 <211> 1255 <212> PRT <213> human SARS virus <220> <221> MISC_FEATURE <223> spike protein <400> 42 Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 1 5 10 15 Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 20 25 30 His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 35 40 45 Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 50 55 60 Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 65 70 75 80 Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 85 90 95 Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 100 105 110 Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 115 120 125 Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 130 135 140 Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 145 150 155 160 Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 165 170 175 Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 180 185 190 Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 195 200 205 Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 210 215 220 Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 225 230 235 240 Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 245 250 255 Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 260 265 270 Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 275 280 285 Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 290 295 300 Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 305 310 315 320 Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 325 330 335 Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 340 345 350 Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 355 360 365 Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 370 375 380 Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 385 390 395 400 Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 405 410 415 Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 420 425 430 Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 435 440 445 Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 450 455 460 Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 465 470 475 480 Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 485 490 495 Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 500 505 510 Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 515 520 525 Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 530 535 540 Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 545 550 555 560 Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 565 570 575 Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 580 585 590 Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr 595 600 605 Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 610 615 620 Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 625 630 635 640 His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 645 650 655 Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 660 665 670 Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 675 680 685 Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 690 695 700 Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 705 710 715 720 Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 725 730 735 Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 740 745 750 Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 755 760 765 Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 770 775 780 Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 785 790 795 800 Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 805 810 815 Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 820 825 830 Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 835 840 845 Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 850 855 860 Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 865 870 875 880 Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 885 890 895 Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 900 905 910 Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 915 920 925 Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 930 935 940 Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 945 950 955 960 Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 965 970 975 Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 980 985 990 Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala 995 1000 1005 Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp 1010 1015 1020 Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ala Ala 1025 1030 1035 Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ser Gln 1040 1045 1050 Glu Arg Asn Phe Thr Thr Ala Pro Ala Ile Cys His Glu Gly Lys 1055 1060 1065 Ala Tyr Phe Pro Arg Glu Gly Val Phe Val Phe Asn Gly Thr Ser 1070 1075 1080 Trp Phe Ile Thr Gln Arg Asn Phe Phe Ser Pro Gln Ile Ile Thr 1085 1090 1095 Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly 1100 1105 1110 Ile Ile Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp 1115 1120 1125 Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser 1130 1135 1140 Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val 1145 1150 1155 Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val Ala Lys 1160 1165 1170 Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys Tyr 1175 1180 1185 Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Val Trp Leu Gly Phe Ile 1190 1195 1200 Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Leu Leu Cys Cys 1205 1210 1215 Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Ala Cys Ser Cys Gly 1220 1225 1230 Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu Lys 1235 1240 1245 Gly Val Lys Leu His Tyr Thr 1250 1255 <210> 43 <211> 1173 <212> PRT <213> human coronavirus 229E <220> <221> MISC_FEATURE <223> spike protein <400> 43 Met Phe Val Leu Leu Val Ala Tyr Ala Leu Leu His Ile Ala Gly Cys 1 5 10 15 Gln Thr Thr Asn Gly Leu Asn Thr Ser Tyr Ser Val Cys Asn Gly Cys 20 25 30 Val Gly Tyr Ser Glu Asn Val Phe Ala Val Glu Ser Gly Gly Tyr Ile 35 40 45 Pro Ser Asp Phe Ala Phe Asn Asn Trp Phe Leu Leu Thr Asn Thr Ser 50 55 60 Ser Val Val Asp Gly Val Val Arg Ser Phe Gln Pro Leu Leu Leu Asn 65 70 75 80 Cys Leu Trp Ser Val Ser Gly Leu Arg Phe Thr Thr Gly Phe Val Tyr 85 90 95 Phe Asn Gly Thr Gly Arg Gly Asp Cys Lys Gly Phe Ser Ser Asp Val 100 105 110 Leu Ser Asp Val Ile Arg Tyr Asn Leu Asn Phe Glu Glu Asn Leu Arg 115 120 125 Arg Gly Thr Ile Leu Phe Lys Thr Ser Tyr Gly Val Val Val Phe Tyr 130 135 140 Cys Thr Asn Asn Thr Leu Val Ser Gly Asp Ala His Ile Pro Phe Gly 145 150 155 160 Thr Val Leu Gly Asn Phe Tyr Cys Phe Val Asn Thr Thr Ile Gly Asn 165 170 175 Glu Thr Thr Ser Ala Phe Val Gly Ala Leu Pro Lys Thr Val Arg Glu 180 185 190 Phe Val Ile Ser Arg Thr Gly His Phe Tyr Ile Asn Gly Tyr Arg Tyr 195 200 205 Phe Thr Leu Gly Asn Val Glu Ala Val Asn Phe Asn Val Thr Thr Ala 210 215 220 Glu Thr Thr Asp Phe Cys Thr Val Ala Leu Ala Ser Tyr Ala Asp Val 225 230 235 240 Leu Val Asn Val Ser Gln Thr Ser Ile Ala Asn Ile Ile Tyr Cys Asn 245 250 255 Ser Val Ile Asn Arg Leu Arg Cys Asp Gln Leu Ser Phe Asp Val Pro 260 265 270 Asp Gly Phe Tyr Ser Thr Ser Pro Ile Gln Ser Val Glu Leu Pro Val 275 280 285 Ser Ile Val Ser Leu Pro Val Tyr His Lys His Thr Phe Ile Val Leu 290 295 300 Tyr Val Asp Phe Lys Pro Gln Ser Gly Gly Gly Lys Cys Phe Asn Cys 305 310 315 320 Tyr Pro Ala Gly Val Asn Ile Thr Leu Ala Asn Phe Asn Glu Thr Lys 325 330 335 Gly Pro Leu Cys Val Asp Thr Ser His Phe Thr Thr Lys Tyr Val Ala 340 345 350 Val Tyr Ala Asn Val Gly Arg Trp Ser Ala Ser Ile Asn Thr Gly Asn 355 360 365 Cys Pro Phe Ser Phe Gly Lys Val Asn Asn Phe Val Lys Phe Gly Ser 370 375 380 Val Cys Phe Ser Leu Lys Asp Ile Pro Gly Gly Cys Ala Met Pro Ile 385 390 395 400 Val Ala Asn Trp Ala Tyr Ser Lys Tyr Tyr Thr Ile Gly Ser Leu Tyr 405 410 415 Val Ser Trp Ser Asp Gly Asp Gly Ile Thr Gly Val Pro Gln Pro Val 420 425 430 Glu Gly Val Ser Ser Phe Met Asn Val Thr Leu Asp Lys Cys Thr Lys 435 440 445 Tyr Asn Ile Tyr Asp Val Ser Gly Val Gly Val Ile Arg Val Ser Asn 450 455 460 Asp Thr Phe Leu Asn Gly Ile Thr Tyr Thr Ser Thr Ser Gly Asn Leu 465 470 475 480 Leu Gly Phe Lys Asp Val Thr Lys Gly Thr Ile Tyr Ser Ile Thr Pro 485 490 495 Cys Asn Pro Pro Asp Gln Leu Val Val Tyr Gln Gln Ala Val Val Gly 500 505 510 Ala Met Leu Ser Glu Asn Phe Thr Ser Tyr Gly Phe Ser Asn Val Val 515 520 525 Glu Leu Pro Lys Phe Phe Tyr Ala Ser Asn Gly Thr Tyr Asn Cys Thr 530 535 540 Asp Ala Val Leu Thr Tyr Ser Ser Phe Gly Val Cys Ala Asp Gly Ser 545 550 555 560 Ile Ile Ala Val Gln Pro Arg Asn Val Ser Tyr Asp Ser Val Ser Ala 565 570 575 Ile Val Thr Ala Asn Leu Ser Ile Pro Ser Asn Trp Thr Thr Ser Val 580 585 590 Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro Ile Val Val Asp Cys 595 600 605 Ser Thr Tyr Val Cys Asn Gly Asn Val Arg Cys Val Glu Leu Leu Lys 610 615 620 Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp Ala Leu Arg Asn Ser 625 630 635 640 Ala Arg Leu Glu Ser Ala Asp Val Ser Glu Met Leu Thr Phe Asp Lys 645 650 655 Lys Ala Phe Thr Leu Ala Asn Val Ser Ser Phe Gly Asp Tyr Asn Leu 660 665 670 Ser Ser Val Ile Pro Ser Leu Pro Thr Ser Gly Ser Arg Val Ala Gly 675 680 685 Arg Ser Ala Ile Glu Asp Ile Leu Phe Ser Lys Leu Val Thr Ser Gly 690 695 700 Leu Gly Thr Val Asp Ala Asp Tyr Lys Lys Cys Thr Lys Gly Leu Ser 705 710 715 720 Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn Gly Ile Met Val Leu 725 730 735 Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met Tyr Thr Gly Ser Leu 740 745 750 Ile Gly Gly Ile Ala Leu Gly Gly Leu Thr Ser Ala Val Ser Ile Pro 755 760 765 Phe Ser Leu Ala Ile Gln Ala Arg Leu Asn Tyr Val Ala Leu Gln Thr 770 775 780 Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala Ala Ser Phe Asn Lys 785 790 795 800 Ala Met Thr Asn Ile Val Asp Ala Phe Thr Gly Val Asn Asp Ala Ile 805 810 815 Thr Gln Thr Ser Gln Ala Leu Gln Thr Val Ala Thr Ala Leu Asn Lys 820 825 830 Ile Gln Asp Val Val Asn Gln Gln Gly Asn Ser Leu Asn His Leu Thr 835 840 845 Ser Gln Leu Arg Gln Asn Phe Gln Ala Ile Ser Ser Ser Ile Gln Ala 850 855 860 Ile Tyr Asp Arg Leu Asp Thr Ile Gln Ala Asp Gln Gln Val Asp Arg 865 870 875 880 Leu Ile Thr Gly Arg Leu Ala Ala Leu Asn Val Phe Val Ser His Thr 885 890 895 Leu Thr Lys Tyr Thr Glu Val Arg Ala Ser Arg Gln Leu Ala Gln Gln 900 905 910 Lys Val Asn Glu Cys Val Lys Ser Gln Ser Lys Arg Tyr Gly Phe Cys 915 920 925 Gly Asn Gly Thr His Ile Phe Ser Ile Val Asn Ala Ala Pro Glu Gly 930 935 940 Leu Val Phe Leu His Thr Val Leu Leu Pro Thr Gln Tyr Lys Asp Val 945 950 955 960 Glu Ala Trp Ser Gly Leu Cys Val Asp Gly Thr Asn Gly Tyr Val Leu 965 970 975 Arg Gln Pro Asn Leu Ala Leu Tyr Lys Glu Gly Asn Tyr Tyr Arg Ile 980 985 990 Thr Ser Arg Ile Met Phe Glu Pro Arg Ile Pro Thr Met Ala Asp Phe 995 1000 1005 Val Gln Ile Glu Asn Cys Asn Val Thr Phe Val Asn Ile Ser Arg 1010 1015 1020 Ser Glu Leu Gln Thr Ile Val Pro Glu Tyr Ile Asp Val Asn Lys 1025 1030 1035 Thr Leu Gln Glu Leu Ser Tyr Lys Leu Pro Asn Tyr Thr Val Pro 1040 1045 1050 Asp Leu Val Val Glu Gln Tyr Asn Gln Thr Ile Leu Asn Leu Thr 1055 1060 1065 Ser Glu Ile Ser Thr Leu Glu Asn Lys Ser Ala Glu Leu Asn Tyr 1070 1075 1080 Thr Val Gln Lys Leu Gln Thr Leu Ile Asp Asn Ile Asn Ser Thr 1085 1090 1095 Leu Val Asp Leu Lys Trp Leu Asn Arg Val Glu Thr Tyr Ile Lys 1100 1105 1110 Trp Pro Trp Trp Val Trp Leu Cys Ile Ser Val Val Leu Ile Phe 1115 1120 1125 Val Val Ser Met Leu Leu Leu Cys Cys Cys Ser Thr Gly Cys Cys 1130 1135 1140 Gly Phe Phe Ser Cys Phe Ala Ser Ser Ile Arg Gly Cys Cys Glu 1145 1150 1155 Ser Thr Lys Leu Pro Tyr Tyr Asp Val Glu Lys Ile His Ile Gln 1160 1165 1170 <210> 44 <211> 226 <212> PRT <213> EMCR coronvirus <220> <221> MISC_FEATURE <223> ORF 4ab <400> 44 Met Pro Phe Gly Gly Leu Phe Gln Leu Thr Leu Glu Ser Thr Ile Asn 1 5 10 15 Lys Ser Val Ala Asn Leu Lys Leu Pro Pro His Asp Val Thr Val Leu 20 25 30 Arg Asp Asn Leu Lys Pro Val Thr Thr Leu Ser Thr Ile Thr Ala Tyr 35 40 45 Leu Leu Val Ser Leu Phe Val Thr Tyr Phe Ala Leu Phe Lys Pro Leu 50 55 60 Thr Ala Arg Gly Arg Val Ala Cys Phe Val Leu Lys Leu Leu Thr Leu 65 70 75 80 Ser Val Tyr Val Pro Leu Leu Val Leu Phe Gly Met Tyr Leu Asp Ser 85 90 95 Phe Ile Ile Phe Phe Leu Arg Cys Cys Phe Asp Ser Tyr Met Leu Ala 100 105 110 Ile Met Pro Ile Ser Asn Lys Asn Phe Ser Phe Val Leu Phe Asn Val 115 120 125 Thr Lys Leu Cys Phe Val Ser Gly Lys Cys Trp Tyr Leu Glu Gln Ser 130 135 140 Phe Tyr Glu Asn Arg Phe Ala Ala Ile Tyr Gly Gly Asp His Tyr Val 145 150 155 160 Val Leu Gly Gly Glu Thr Ile Thr Phe Val Ser Phe Asp Asp Leu Tyr 165 170 175 Val Ala Ile Arg Gly Ser Cys Glu Lys Asn Leu Gln Leu Met Arg Lys 180 185 190 Val Asp Leu Tyr Asn Gly Ala Val Ile Tyr Ile Phe Ala Glu Glu Pro 195 200 205 Val Val Gly Ile Val Tyr Ser Ser Gln Leu Tyr Glu Asp Val Pro Ser 210 215 220 Ile Asn 225 <210> 45 <211> 88 <212> PRT <213> human coronavirus 229E <220> <221> MISC_FEATURE <223> ORF 4b <400> 45 Met Gln Gly Lys Cys Trp Phe Leu Glu Asn Lys Ala Leu Lys Pro Phe 1 5 10 15 Val Cys Phe Tyr Gly Gly Asp Gln Phe Leu Tyr Ile Gly Asp Arg Ile 20 25 30 Val Ser Tyr Phe Ser Thr Asn Asp Leu Tyr Val Ala Leu Arg Gly Arg 35 40 45 Ile Asp Lys Asp Leu Ser Leu Ser Arg Lys Val Glu Leu Tyr Asn Gly 50 55 60 Glu Cys Val Tyr Leu Phe Cys Glu His Pro Ala Val Gly Ile Val Asn 65 70 75 80 Thr Asp Phe Lys Leu Glu Ile His 85 <210> 46 <211> 133 <212> PRT <213> human coronavirus 229E <220> <221> MISC_FEATURE <223> ORF 4a <400> 46 Met Ala Leu Gly Leu Phe Thr Leu Gln Leu Val Ser Ala Val Asn Gln 1 5 10 15 Ser Leu Ser Asn Ala Lys Val Ser Ala Glu Val Ser Arg Gln Val Ile 20 25 30 Gln Asp Val Lys Asp Gly Thr Val Thr Phe Asn Leu Leu Ala Tyr Thr 35 40 45 Leu Met Ser Leu Phe Val Val Tyr Phe Ala Leu Phe Lys Ala Arg Ser 50 55 60 His Arg Gly Arg Ala Ala Leu Ile Val Phe Lys Ile Leu Ile Leu Phe 65 70 75 80 Val Tyr Val Pro Leu Leu Tyr Trp Ser Gln Ala Tyr Ile Tyr Ala Thr 85 90 95 Leu Ile Ala Val Ile Leu Leu Gly Arg Phe Phe His Thr Ala Trp His 100 105 110 Cys Trp Leu Tyr Lys Thr Trp Asp Phe Ile Val Phe Asn Val Thr Thr 115 120 125 Leu Cys Tyr Ala Arg 130 <210> 47 <211> 82 <212> PRT <213> transmissable gastroenteritis virus <220> <221> MISC_FEATURE <223> ORF E <400> 47 Met Thr Phe Pro Arg Ala Leu Thr Val Ile Asp Asp Asn Gly Met Val 1 5 10 15 Ile Asn Ile Ile Phe Trp Phe Leu Leu Ile Ile Ile Leu Ile Leu Leu 20 25 30 Ser Ile Ala Leu Leu Asn Ile Ile Lys Leu Cys Met Val Cys Cys Asn 35 40 45 Leu Gly Arg Thr Val Ile Ile Val Pro Ala Gln His Ala Tyr Asp Ala 50 55 60 Tyr Lys Asn Phe Met Arg Ile Lys Ala Tyr Asn Pro Asp Gly Ala Leu 65 70 75 80 Leu Ala <210> 48 <211> 108 <212> PRT <213> avian infectious bronchitis virus <220> <221> MISC_FEATURE <223> ORF E <400> 48 Met Asn Leu Leu Asn Lys Ser Leu Glu Glu Asn Gly Ser Phe Leu Thr 1 5 10 15 Ala Leu Tyr Ile Ile Val Gly Phe Leu Ala Leu Tyr Leu Leu Gly Arg 20 25 30 Ala Leu Gln Ala Phe Val Gln Ala Ala Asp Ala Cys Cys Leu Phe Trp 35 40 45 Tyr Thr Trp Val Val Ile Pro Gly Ala Lys Gly Thr Ala Phe Val Tyr 50 55 60 Lys Tyr Thr Tyr Gly Arg Lys Leu Asn Asn Pro Glu Leu Glu Ala Val 65 70 75 80 Ile Val Asn Glu Phe Pro Lys Asn Gly Trp Asn Asn Lys Asn Pro Ala 85 90 95 Asn Phe Gln Asp Ala Gln Arg Asp Lys Leu Tyr Ser 100 105 <210> 49 <211> 84 <212> PRT <213> bovine coronavirus <220> <221> MISC_FEATURE <223> ORF E <400> 49 Met Phe Met Ala Asp Ala Tyr Phe Ala Asp Thr Val Trp Tyr Val Gly 1 5 10 15 Gln Ile Ile Phe Ile Val Ala Ile Cys Leu Leu Val Ile Ile Val Val 20 25 30 Val Ala Phe Leu Ala Thr Phe Lys Leu Cys Ile Gln Leu Cys Gly Met 35 40 45 Cys Asn Thr Leu Val Leu Ser Pro Ser Ile Tyr Val Phe Asn Arg Gly 50 55 60 Arg Gln Phe Tyr Glu Phe Tyr Asn Asp Val Lys Pro Pro Val Leu Asp 65 70 75 80 Val Asp Asp Val <210> 50 <211> 82 <212> PRT <213> canine coronavirus <220> <221> MISC_FEATURE <223> ORF E <400> 50 Met Thr Phe Pro Arg Ala Leu Thr Val Ile Asp Asp Asn Gly Met Val 1 5 10 15 Ile Ser Ile Ile Phe Trp Phe Leu Leu Ile Ile Ile Leu Ile Leu Phe 20 25 30 Ser Ile Ala Leu Leu Asn Ile Ile Lys Leu Cys Met Val Cys Cys Asn 35 40 45 Leu Gly Arg Thr Val Ile Ile Val Pro Ala Arg His Ala Tyr Asp Ala 50 55 60 Tyr Lys Asn Phe Met Gln Ile Arg Ala Tyr Asn Pro Asp Glu Ala Leu 65 70 75 80 Leu Val <210> 51 <211> 77 <212> PRT <213> EMCR coronavirus <220> <221> MISC_FEATURE <223> ORF E <400> 51 Met Phe Leu Arg Leu Ile Asp Asp Asn Gly Ile Val Leu Asn Ser Ile 1 5 10 15 Leu Trp Leu Leu Val Met Ile Phe Phe Phe Val Leu Ala Met Thr Phe 20 25 30 Ile Lys Leu Ile Gln Leu Cys Phe Thr Cys His Tyr Phe Phe Ser Arg 35 40 45 Thr Leu Tyr Gln Pro Val Tyr Lys Ile Phe Leu Ala Tyr Gln Asp Tyr 50 55 60 Met Gln Ile Ala Pro Val Pro Ala Glu Val Leu Asn Val 65 70 75 <210> 52 <211> 82 <212> PRT <213> feline coronavirus <220> <221> MISC_FEATURE <223> ORF E <400> 52 Met Thr Phe Pro Arg Ala Phe Thr Ile Ile Asp Asp His Gly Met Val 1 5 10 15 Val Ser Val Phe Phe Trp Leu Leu Leu Ile Ile Ile Leu Ile Leu Phe 20 25 30 Ser Ile Ala Leu Leu Asn Val Ile Lys Leu Cys Met Val Cys Cys Asn 35 40 45 Leu Gly Lys Thr Ile Ile Val Leu Pro Ala Arg His Ala Tyr Asp Ala 50 55 60 Tyr Lys Thr Phe Met Gln Thr Lys Ala Tyr Asn Pro Asp Glu Ala Phe 65 70 75 80 Leu Val <210> 53 <211> 88 <212> PRT <213> murine hepatitis virus <220> <221> MISC_FEATURE <223> ORF E <400> 53 Met Phe Asn Leu Phe Leu Thr Asp Thr Val Trp Tyr Val Gly Gln Ile 1 5 10 15 Ile Phe Ile Val Ala Val Cys Leu Met Val Thr Ile Ile Val Val Ala 20 25 30 Phe Leu Ala Ser Ile Lys Leu Cys Ile Gln Leu Cys Gly Leu Cys Asn 35 40 45 Thr Leu Leu Leu Ser Pro Ser Ile Cys Val Tyr Asn Arg Ser Lys Gln 50 55 60 Leu Tyr Lys Tyr Tyr Asn Glu Glu Val Arg Pro Pro Pro Leu Glu Val 65 70 75 80 Asp Asp Ile Ile Ile Gln Thr Leu 85 <210> 54 <211> 84 <212> PRT <213> human coronavirus OC43 <220> <221> MISC_FEATURE <223> ORF E <400> 54 Met Phe Met Ala Asp Ala Tyr Leu Ala Asp Thr Val Trp Tyr Val Gly 1 5 10 15 Gln Ile Ile Phe Ile Val Ala Ile Cys Leu Leu Val Thr Ile Val Val 20 25 30 Val Ala Phe Leu Ala Thr Phe Lys Leu Cys Ile Gln Leu Cys Gly Met 35 40 45 Cys Asn Thr Leu Val Leu Ser Pro Ser Ile Tyr Val Phe Asn Arg Gly 50 55 60 Arg Gln Phe Tyr Glu Phe Tyr Asn Asp Val Lys Pro Pro Val Leu Asp 65 70 75 80 Val Asp Asp Val <210> 55 <211> 76 <212> PRT <213> porcine epidemic diarrhea virus <220> <221> MISC_FEATURE <223> ORF E <400> 55 Met Leu Gln Leu Val Asn Asp Asn Gly Leu Val Val Asn Val Ile Leu 1 5 10 15 Trp Leu Phe Val Leu Phe Phe Leu Leu Ile Ile Ser Ile Thr Phe Val 20 25 30 Gln Leu Val Asn Leu Cys Phe Thr Cys His Arg Leu Cys Asn Ser Ala 35 40 45 Val Tyr Thr Pro Ile Gly Arg Leu Tyr Arg Val Tyr Lys Ser Tyr Met 50 55 60 Arg Ile Asp Pro Leu Pro Ser Thr Val Ile Asp Val 65 70 75 <210> 56 <211> 84 <212> PRT <213> porcine haemagglutinating encephalomyelitis virus <220> <221> MISC_FEATURE <223> ORF E <400> 56 Met Phe Met Ala Asp Ala Tyr Leu Ala Asp Thr Val Trp Tyr Val Gly 1 5 10 15 Gln Ile Ile Phe Ile Val Ala Ile Cys Leu Leu Val Ile Ile Val Val 20 25 30 Val Ala Phe Leu Ala Thr Phe Lys Leu Cys Ile Gln Leu Cys Gly Met 35 40 45 Cys Asn Thr Leu Val Leu Ser Pro Ser Ile Tyr Val Phe Asn Arg Gly 50 55 60 Arg Gln Phe Tyr Glu Phe Tyr Asn Asp Val Lys Pro Pro Val Leu Asp 65 70 75 80 Val Asp Asp Val <210> 57 <211> 82 <212> PRT <213> porcine respiratory coronavirus <220> <221> MISC_FEATURE <223> ORF E <400> 57 Met Thr Phe Pro Arg Ala Leu Thr Val Ile Asp Asp Asn Gly Met Val 1 5 10 15 Ile Ser Ile Ile Phe Trp Phe Leu Leu Ile Ile Ile Leu Ile Leu Leu 20 25 30 Ser Ile Ala Leu Leu Asn Ile Ile Lys Leu Cys Met Val Cys Cys Asn 35 40 45 Leu Gly Arg Thr Val Ile Ile Val Pro Val Gln His Ala Tyr Asp Ala 50 55 60 Tyr Lys Asn Phe Met Arg Ile Lys Ala Tyr Asn Pro Asp Gly Ala Leu 65 70 75 80 Leu Val <210> 58 <211> 88 <212> PRT <213> rat coronavirus <220> <221> MISC_FEATURE <223> ORF E <400> 58 Met Phe Asn Leu Phe Leu Ile Asp Thr Val Trp Tyr Val Gly Gln Ile 1 5 10 15 Ile Phe Ile Val Ala Val Cys Leu Met Val Thr Ile Ile Val Val Ala 20 25 30 Phe Leu Ala Ser Ile Lys Leu Cys Ile Gln Leu Cys Gly Leu Cys Asn 35 40 45 Thr Leu Leu Leu Ser Pro Ser Ile Tyr Val Tyr Asn Arg Ser Lys Gln 50 55 60 Leu Tyr Lys Tyr Tyr Asn Glu Glu Val Arg Pro Pro Pro Leu Glu Val 65 70 75 80 Asp Asp Ile Ile Ile Gln Thr Leu 85 <210> 59 <211> 76 <212> PRT <213> human SARS virus <220> <221> MISC_FEATURE <223> ORF E <400> 59 Met Tyr Ser Phe Val Ser Glu Glu Thr Gly Thr Leu Ile Val Asn Ser 1 5 10 15 Val Leu Leu Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala 20 25 30 Ile Leu Thr Ala Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile Val Asn 35 40 45 Val Ser Leu Val Lys Pro Thr Val Tyr Val Tyr Ser Arg Val Lys Asn 50 55 60 Leu Asn Ser Ser Glu Gly Val Pro Asp Leu Leu Val 65 70 75 <210> 60 <211> 77 <212> PRT <213> human coronavirus 229E <220> <221> MISC_FEATURE <223> ORF E <400> 60 Met Phe Leu Lys Leu Val Asp Asp His Ala Leu Val Val Asn Val Leu 1 5 10 15 Leu Trp Cys Val Val Leu Ile Val Ile Leu Leu Val Cys Ile Thr Ile 20 25 30 Ile Lys Leu Ile Lys Leu Cys Phe Thr Cys His Met Phe Cys Asn Arg 35 40 45 Thr Val Tyr Gly Pro Ile Lys Asn Val Tyr His Ile Tyr Gln Ser Tyr 50 55 60 Met His Ile Asp Pro Phe Pro Lys Arg Val Ile Asp Phe 65 70 75 <210> 61 <211> 262 <212> PRT <213> transmissible gastroenteritis virus <220> <221> MISC_FEATURE <223> ORF M <400> 61 Met Lys Ile Leu Leu Ile Leu Ala Cys Val Ile Ala Cys Ala Cys Gly 1 5 10 15 Glu Arg Tyr Cys Ala Met Lys Ser Asp Thr Asp Leu Ser Cys Arg Asn 20 25 30 Ser Thr Ala Ser Asp Cys Glu Ser Cys Phe Asn Gly Gly Asp Leu Ile 35 40 45 Trp His Leu Ala Asn Trp Asn Phe Ser Trp Ser Ile Ile Leu Ile Val 50 55 60 Phe Ile Thr Val Leu Gln Tyr Gly Arg Pro Gln Phe Ser Trp Phe Val 65 70 75 80 Tyr Gly Ile Lys Met Leu Ile Met Trp Leu Leu Trp Pro Val Val Leu 85 90 95 Ala Leu Thr Ile Phe Asn Ala Tyr Ser Glu Tyr Gln Val Ser Arg Tyr 100 105 110 Val Met Phe Gly Phe Ser Ile Ala Gly Ala Ile Val Thr Phe Val Leu 115 120 125 Trp Ile Met Tyr Phe Val Arg Ser Ile Gln Leu Tyr Arg Arg Thr Lys 130 135 140 Ser Trp Trp Ser Phe Asn Pro Glu Thr Lys Ala Ile Leu Cys Val Ser 145 150 155 160 Ala Leu Gly Arg Ser Tyr Val Leu Pro Leu Glu Gly Val Pro Thr Gly 165 170 175 Val Thr Leu Thr Leu Leu Ser Gly Asn Leu Tyr Ala Glu Gly Phe Lys 180 185 190 Ile Ala Gly Gly Met Asn Ile Asp Asn Leu Pro Lys Tyr Val Met Val 195 200 205 Ala Leu Pro Ser Arg Thr Ile Val Tyr Thr Leu Val Gly Lys Lys Leu 210 215 220 Lys Ala Ser Ser Ala Thr Gly Trp Ala Tyr Tyr Val Lys Ser Lys Ala 225 230 235 240 Gly Asp Tyr Ser Thr Glu Ala Arg Thr Asp Asn Leu Ser Glu Gln Glu 245 250 255 Lys Leu Leu His Met Val 260 <210> 62 <211> 225 <212> PRT <213> avian infectious bronchitis virus <220> <221> MISC_FEATURE <223> ORF M <400> 62 Met Pro Asn Glu Thr Asn Cys Thr Leu Asp Phe Glu Gln Ser Val Gln 1 5 10 15 Leu Phe Lys Glu Tyr Asn Leu Phe Ile Thr Ala Phe Leu Leu Phe Leu 20 25 30 Thr Ile Ile Leu Gln Tyr Gly Tyr Ala Thr Arg Ser Lys Val Ile Tyr 35 40 45 Thr Leu Lys Met Ile Val Leu Trp Cys Phe Trp Pro Leu Asn Ile Ala 50 55 60 Val Gly Val Ile Ser Cys Thr Tyr Pro Pro Asn Thr Gly Gly Leu Val 65 70 75 80 Ala Ala Ile Ile Leu Thr Val Phe Ala Cys Leu Ser Phe Val Gly Tyr 85 90 95 Trp Ile Gln Ser Ile Arg Leu Phe Lys Arg Cys Arg Ser Trp Trp Ser 100 105 110 Phe Asn Pro Glu Ser Asn Ala Val Gly Ser Ile Leu Leu Thr Asn Gly 115 120 125 Gln Gln Cys Asn Phe Ala Ile Glu Ser Val Pro Met Val Leu Ser Pro 130 135 140 Ile Ile Lys Asn Gly Val Leu Tyr Cys Glu Gly Gln Trp Leu Ala Lys 145 150 155 160 Cys Glu Pro Asp His Leu Pro Lys Asp Ile Phe Val Cys Thr Pro Asp 165 170 175 Arg Arg Asn Ile Tyr Arg Met Val Gln Lys Tyr Thr Gly Asp Gln Ser 180 185 190 Gly Asn Lys Lys Arg Phe Ala Thr Phe Val Tyr Ala Lys Gln Ser Val 195 200 205 Asp Thr Gly Glu Leu Glu Ser Val Ala Thr Gly Gly Ser Ser Leu Tyr 210 215 220 Thr 225 <210> 63 <211> 230 <212> PRT <213> bovina coronavirus <220> <221> MISC_FEATURE <223> ORF M <400> 63 Met Ser Ser Val Thr Thr Pro Ala Pro Val Tyr Thr Trp Thr Ala Asp 1 5 10 15 Glu Ala Ile Lys Phe Leu Lys Glu Trp Asn Phe Ser Leu Gly Ile Ile 20 25 30 Leu Leu Phe Ile Thr Ile Ile Leu Gln Phe Gly Tyr Thr Ser Arg Ser 35 40 45 Met Phe Val Tyr Val Ile Lys Met Ile Ile Leu Trp Leu Met Trp Pro 50 55 60 Leu Thr Ile Ile Leu Thr Ile Phe Asn Cys Val Tyr Ala Leu Asn Asn 65 70 75 80 Val Tyr Leu Gly Phe Ser Ile Val Phe Thr Ile Val Ala Ile Ile Met 85 90 95 Trp Ile Val Tyr Phe Val Asn Ser Ile Arg Leu Phe Ile Arg Thr Gly 100 105 110 Ser Trp Trp Ser Phe Asn Pro Glu Thr Asn Asn Leu Met Cys Ile Asp 115 120 125 Met Lys Gly Arg Met Tyr Val Arg Pro Ile Ile Glu Asp Tyr His Thr 130 135 140 Leu Thr Val Thr Ile Ile Arg Gly His Leu Tyr Met Gln Gly Ile Lys 145 150 155 160 Leu Gly Thr Gly Tyr Ser Leu Ser Asp Leu Pro Ala Tyr Val Thr Val 165 170 175 Ala Lys Val Ser His Leu Leu Thr Tyr Lys Arg Gly Phe Leu Asp Lys 180 185 190 Ile Gly Asp Thr Ser Gly Phe Ala Val Tyr Val Lys Ser Lys Val Gly 195 200 205 Asn Tyr Arg Leu Pro Ser Thr Gln Lys Gly Ser Gly Met Asp Thr Ala 210 215 220 Leu Leu Arg Asn Asn Ile 225 230 <210> 64 <211> 262 <212> PRT <213> canine coronavirus <220> <221> MISC_FEATURE <223> ORF M <400> 64 Met Lys Lys Ile Leu Phe Leu Leu Ala Cys Ala Ile Ala Cys Val Tyr 1 5 10 15 Gly Glu Arg Tyr Cys Ala Met Thr Glu Ser Ser Thr Ser Cys Arg Asn 20 25 30 Ser Thr Ala Gly Asn Cys Ala Ser Cys Phe Glu Thr Gly Asp Leu Ile 35 40 45 Trp His Leu Ala Asn Trp Asn Phe Ser Trp Ser Val Ile Leu Ile Ile 50 55 60 Phe Ile Thr Val Leu Gln Tyr Gly Arg Pro Gln Phe Ser Trp Phe Val 65 70 75 80 Cys Gly Ile Lys Met Leu Ile Met Trp Leu Leu Trp Pro Ile Val Leu 85 90 95 Ala Leu Thr Ile Phe Asn Ala Tyr Leu Glu Tyr Arg Val Ser Arg Tyr 100 105 110 Val Met Phe Gly Phe Ser Val Ala Gly Ala Thr Val Thr Phe Ile Leu 115 120 125 Trp Ile Met Tyr Phe Val Arg Ser Ile Gln Leu Tyr Arg Arg Thr Lys 130 135 140 Ser Trp Trp Ser Phe Asn Pro Glu Thr Ser Ala Ile Leu Cys Val Ser 145 150 155 160 Ala Leu Gly Arg Ser Tyr Val Leu Pro Leu Glu Gly Val Pro Thr Gly 165 170 175 Val Thr Leu Thr Leu Leu Ser Gly Asn Leu Cys Ala Glu Gly Phe Lys 180 185 190 Ile Ala Gly Gly Met Asn Ile Asp Asn Leu Pro Lys Tyr Val Met Val 195 200 205 Ala Leu Pro Val Arg Thr Ile Val Tyr Thr Leu Val Gly Lys Lys Leu 210 215 220 Lys Ala Ser Ser Ala Thr Gly Trp Ala Tyr Tyr Val Lys Ser Lys Ala 225 230 235 240 Gly Asp Tyr Ser Thr Asp Ala Arg Thr Asp Asn Leu Ser Glu His Glu 245 250 255 Lys Leu Leu His Met Val 260 <210> 65 <211> 226 <212> PRT <213> EMCR coronavirus <220> <221> MISC_FEATURE <223> ORF M <400> 65 Met Ser Asn Ser Ser Val Pro Leu Ser Glu Val Tyr Val His Leu Arg 1 5 10 15 Asn Trp Asn Phe Ser Trp Asn Leu Ile Leu Thr Val Phe Ile Val Val 20 25 30 Leu Gln Tyr Gly His Tyr Lys Tyr Ser Arg Leu Leu Tyr Gly Leu Lys 35 40 45 Met Ser Val Leu Trp Cys Leu Trp Pro Leu Val Leu Ala Leu Ser Ile 50 55 60 Phe Asp Cys Phe Val Asn Phe Asn Val Asp Trp Val Phe Phe Gly Phe 65 70 75 80 Ser Ile Leu Met Ser Ile Ile Thr Leu Cys Leu Trp Val Met Tyr Phe 85 90 95 Val Asn Ser Phe Arg Leu Trp Arg Arg Val Lys Thr Phe Trp Ala Phe 100 105 110 Asn Pro Glu Thr Asn Ala Ile Ile Ser Leu Gln Val Tyr Gly His Asn 115 120 125 Tyr Tyr Leu Pro Val Met Ala Ala Pro Thr Gly Val Thr Leu Thr Leu 130 135 140 Leu Ser Gly Val Leu Leu Val Asp Gly His Lys Ile Ala Thr Arg Val 145 150 155 160 Gln Val Gly Gln Leu Pro Lys Tyr Val Ile Val Ala Thr Pro Ser Thr 165 170 175 Thr Ile Val Cys Asp Arg Val Gly Arg Ser Val Asn Glu Thr Ser Gln 180 185 190 Thr Gly Trp Ala Phe Tyr Val Arg Ala Lys His Gly Asp Phe Ser Gly 195 200 205 Val Ala Ser Gln Glu Gly Val Leu Ser Glu Arg Glu Lys Leu Leu His 210 215 220 Leu Ile 225 <210> 66 <211> 289 <212> PRT <213> feline coronavirus <220> <221> MISC_FEATURE <223> ORF M <400> 66 Met His Met Met Pro Ile Arg Pro Leu Cys Lys Pro Arg His Ile Ile 1 5 10 15 Pro Thr Lys His Phe Trp Phe Glu Leu Asn Lys Met Lys Tyr Ile Leu 20 25 30 Leu Ile Leu Ala Cys Ile Ile Ala Cys Val Tyr Gly Glu Arg Tyr Cys 35 40 45 Ala Met Gln Asp Ser Gly Leu Gln Cys Ile Asn Gly Thr Asn Ser Arg 50 55 60 Cys Gln Thr Cys Phe Glu Arg Gly Asp Leu Ile Trp His Leu Ala Asn 65 70 75 80 Trp Asn Phe Ser Trp Ser Val Ile Leu Ile Val Phe Ile Thr Val Leu 85 90 95 Gln Tyr Gly Arg Pro Gln Phe Ser Trp Leu Val Tyr Gly Ile Lys Met 100 105 110 Leu Ile Met Trp Leu Leu Trp Pro Ile Val Leu Ala Leu Thr Ile Phe 115 120 125 Asn Ala Tyr Ser Glu Tyr Gln Val Ser Arg Tyr Val Met Phe Gly Phe 130 135 140 Ser Val Ala Gly Ala Val Val Thr Phe Ala Leu Trp Met Met Tyr Phe 145 150 155 160 Val Arg Ser Val Gln Leu Tyr Arg Arg Thr Lys Ser Trp Trp Ser Phe 165 170 175 Asn Pro Glu Thr Asn Ala Ile Leu Cys Val Asn Ala Leu Gly Arg Ser 180 185 190 Tyr Val Leu Pro Leu Asp Gly Thr Pro Thr Gly Val Thr Leu Thr Leu 195 200 205 Leu Ser Gly Asn Leu Tyr Ala Glu Gly Phe Lys Met Ala Gly Gly Leu 210 215 220 Thr Ile Glu His Leu Pro Lys Tyr Val Met Ile Ala Thr Pro Ser Arg 225 230 235 240 Thr Ile Val Tyr Thr Leu Val Gly Lys Gln Leu Lys Ala Thr Thr Ala 245 250 255 Thr Gly Trp Ala Tyr Tyr Val Lys Ser Lys Ala Gly Asp Tyr Ser Thr 260 265 270 Glu Ala Arg Thr Asp Asn Leu Ser Glu His Glu Lys Leu Leu His Met 275 280 285 Val <210> 67 <211> 228 <212> PRT <213> murine hepatitis virus <220> <221> MISC_FEATURE <223> ORF M <400> 67 Met Thr Ser Thr Thr Gln Ala Pro Gln Pro Val Tyr Gln Trp Thr Ala 1 5 10 15 Asp Glu Ala Ile Arg Phe Leu Lys Glu Trp Asn Phe Ser Leu Gly Ile 20 25 30 Ile Leu Leu Phe Val Thr Ile Ile Leu Gln Phe Gly Tyr Thr Ser Arg 35 40 45 Ser Met Phe Val Tyr Val Val Lys Met Ile Leu Leu Trp Leu Met Trp 50 55 60 Pro Leu Thr Ile Val Leu Cys Ile Phe Asn Cys Val Tyr Ala Leu Asn 65 70 75 80 Asn Val Tyr Leu Gly Phe Ser Ile Val Phe Thr Ile Val Ser Ile Ile 85 90 95 Met Trp Ile Met Tyr Phe Val Asn Ser Ile Arg Leu Phe Ile Arg Thr 100 105 110 Gly Ser Trp Trp Ser Phe Asn Pro Glu Thr Asn Asn Leu Met Cys Ile 115 120 125 Asp Met Lys Gly Thr Val Tyr Val Arg Pro Ile Ile Glu Asp Tyr His 130 135 140 Thr Leu Thr Ala Thr Ile Ile Arg Gly His Leu Tyr Met Gln Gly Val 145 150 155 160 Lys Leu Gly Thr Gly Phe Ser Leu Ser Asp Leu Pro Ala Tyr Val Thr 165 170 175 Val Ala Lys Val Ser His Leu Cys Thr Tyr Lys Arg Ala Phe Leu Asp 180 185 190 Lys Val Asp Gly Val Ser Gly Phe Ala Val Tyr Val Lys Ser Lys Val 195 200 205 Gly Asn Tyr Arg Leu Pro Ser Asn Lys Pro Ser Gly Met Asp Thr Ala 210 215 220 Leu Leu Arg Ile 225 <210> 68 <211> 230 <212> PRT <213> human coronavirus OC43 <220> <221> MISC_FEATURE <223> ORF M <400> 68 Met Ser Ser Lys Thr Thr Pro Ala Pro Val Tyr Ile Trp Thr Ala Asp 1 5 10 15 Glu Ala Ile Lys Phe Leu Lys Glu Trp Asn Phe Ser Leu Gly Ile Ile 20 25 30 Leu Leu Phe Ile Thr Ile Ile Leu Gln Phe Gly Tyr Thr Ser Arg Ser 35 40 45 Met Phe Val Tyr Val Ile Lys Met Ile Ile Leu Trp Leu Met Trp Pro 50 55 60 Leu Thr Ile Ile Leu Thr Ile Phe Asn Cys Val Tyr Ala Leu Asn Asn 65 70 75 80 Val Tyr Leu Gly Leu Ser Ile Val Phe Thr Ile Val Ala Ile Ile Met 85 90 95 Trp Ile Val Tyr Phe Val Asn Ser Ile Arg Leu Phe Ile Arg Thr Gly 100 105 110 Ser Phe Trp Ser Phe Asn Pro Glu Thr Asn Asn Leu Met Cys Ile Asp 115 120 125 Met Lys Gly Thr Met Tyr Val Arg Pro Ile Ile Glu Asp Tyr His Thr 130 135 140 Leu Thr Val Thr Ile Ile Arg Gly His Leu Tyr Ile Gln Gly Ile Lys 145 150 155 160 Leu Gly Thr Gly Tyr Ser Leu Ala Asp Leu Pro Ala Tyr Met Thr Val 165 170 175 Ala Lys Val Thr His Leu Cys Thr Tyr Lys Arg Gly Phe Leu Asp Arg 180 185 190 Ile Ser Asp Thr Ser Gly Phe Ala Val Tyr Val Lys Ser Lys Val Gly 195 200 205 Asn Tyr Arg Leu Pro Ser Thr Gln Lys Gly Ser Gly Met Asp Thr Ala 210 215 220 Leu Leu Arg Asn Asn Ile 225 230 <210> 69 <211> 226 <212> PRT <213> porcine epidemic diarrhea virus <220> <221> MISC_FEATURE <223> ORF M <400> 69 Met Ser Asn Gly Ser Ile Pro Val Asp Glu Val Ile Glu His Leu Arg 1 5 10 15 Asn Trp Asn Phe Thr Trp Asn Ile Ile Leu Thr Ile Leu Leu Val Val 20 25 30 Leu Gln Tyr Gly His Tyr Lys Tyr Ser Val Phe Leu Tyr Gly Val Lys 35 40 45 Met Ala Ile Leu Trp Ile Leu Trp Pro Leu Val Leu Ala Leu Ser Leu 50 55 60 Phe Asp Ala Trp Ala Ser Phe Gln Val Asn Trp Val Phe Phe Ala Phe 65 70 75 80 Ser Ile Leu Met Ala Cys Ile Thr Leu Met Leu Trp Ile Met Tyr Phe 85 90 95 Val Asn Ser Ile Arg Leu Trp Arg Arg Thr His Ser Trp Trp Ser Phe 100 105 110 Asn Pro Glu Thr Asp Ala Leu Leu Thr Thr Ser Val Met Gly Arg Gln 115 120 125 Val Cys Ile Pro Val Leu Gly Ala Pro Thr Gly Val Thr Leu Thr Leu 130 135 140 Leu Ser Gly Thr Leu Leu Val Glu Gly Tyr Lys Val Ala Thr Gly Val 145 150 155 160 Gln Val Ser Gln Leu Pro Asn Phe Val Thr Val Ala Lys Ala Thr Thr 165 170 175 Thr Ile Val Tyr Gly Arg Val Gly Arg Ser Val Asn Ala Ser Ser Gly 180 185 190 Thr Gly Trp Ala Phe Tyr Val Arg Ser Lys His Gly Asp Tyr Ser Ala 195 200 205 Val Ser Asn Pro Ser Ala Val Leu Thr Asp Ser Glu Lys Val Leu His 210 215 220 Leu Val 225 <210> 70 <211> 230 <212> PRT <213> porcine haemagglutinating encephalomyelitis virus <220> <221> MISC_FEATURE <223> ORF M <400> 70 Met Ser Ser Pro Thr Thr Pro Val Pro Val Ile Ser Trp Thr Ala Asp 1 5 10 15 Glu Ala Ile Lys Phe Leu Lys Glu Trp Asn Phe Ser Leu Gly Ile Ile 20 25 30 Val Leu Phe Ile Thr Ile Ile Leu Gln Phe Gly Tyr Thr Ser Arg Ser 35 40 45 Met Phe Val Tyr Val Ile Lys Met Val Ile Leu Trp Leu Met Trp Pro 50 55 60 Leu Thr Ile Ile Leu Thr Ile Phe Asn Cys Val Tyr Ala Leu Asn Asn 65 70 75 80 Val Tyr Leu Gly Phe Ser Ile Val Phe Thr Ile Val Ala Ile Ile Met 85 90 95 Trp Val Val Tyr Phe Val Asn Ser Ile Arg Leu Phe Ile Arg Thr Gly 100 105 110 Ser Trp Trp Ser Phe Asn Pro Glu Thr Asn Asn Leu Met Cys Ile Asp 115 120 125 Met Lys Gly Arg Met Tyr Val Arg Pro Ile Ile Glu Asp Tyr His Thr 130 135 140 Leu Thr Ala Thr Ile Ile Arg Gly His Leu Tyr Ile Gln Gly Ile Lys 145 150 155 160 Leu Gly Thr Gly Tyr Ser Leu Ser Asp Leu Pro Ala Tyr Val Thr Val 165 170 175 Ala Lys Val Thr His Leu Cys Thr Tyr Lys Arg Gly Phe Leu Asp Arg 180 185 190 Ile Gly Asp Thr Ser Gly Phe Ala Val Tyr Val Lys Ser Lys Val Gly 195 200 205 Asn Tyr Arg Leu Pro Ser Thr His Lys Gly Ser Gly Met Asp Thr Ala 210 215 220 Leu Leu Arg Asn Asn Ile 225 230 <210> 71 <211> 262 <212> PRT <213> porcine respiratory coronavirus <220> <221> MISC_FEATURE <223> ORF M <400> 71 Met Lys Ile Leu Leu Ile Leu Ala Cys Ala Ile Ala Cys Thr Cys Gly 1 5 10 15 Glu Arg Tyr Cys Ala Met Lys Asp Asp Thr Gly Leu Ser Cys Arg Asn 20 25 30 Gly Thr Ala Ser Asp Cys Glu Ser Cys Phe Asn Arg Gly Asp Leu Ile 35 40 45 Trp Leu Leu Ala Asn Trp Asn Phe Ser Trp Ser Ile Ile Leu Ile Ile 50 55 60 Phe Ile Thr Val Leu Gln Tyr Gly Arg Pro Gln Phe Ser Trp Phe Val 65 70 75 80 Tyr Gly Ile Lys Met Leu Ile Met Trp Leu Leu Trp Pro Ile Val Leu 85 90 95 Ala Leu Thr Ile Phe Asn Ala Tyr Ser Glu Tyr Gln Val Ser Arg Tyr 100 105 110 Val Met Phe Gly Phe Ser Ile Ala Gly Ala Ile Val Thr Phe Val Leu 115 120 125 Trp Ile Met Tyr Phe Val Arg Ser Ile Gln Leu Tyr Arg Arg Thr Lys 130 135 140 Ser Trp Trp Ser Phe Asn Pro Glu Thr Asn Ala Ile Leu Cys Val Ser 145 150 155 160 Ala Leu Gly Arg Ser Tyr Val Leu Pro Leu Glu Gly Val Pro Thr Gly 165 170 175 Val Thr Leu Thr Leu Leu Ser Gly Asn Leu Tyr Ala Glu Gly Phe Lys 180 185 190 Ile Ala Gly Gly Met Thr Ile Asp Asn Leu Pro Lys Tyr Val Met Val 195 200 205 Ala Leu Pro Ser Arg Thr Ile Val Tyr Thr Leu Val Gly Lys Lys Leu 210 215 220 Lys Ala Ser Ser Ala Thr Gly Trp Ala Tyr Tyr Val Lys Ser Lys Ala 225 230 235 240 Gly Asp Tyr Ser Thr Glu Ala Arg Thr Asp Asn Leu Ser Glu Gln Glu 245 250 255 Lys Leu Leu His Met Val 260 <210> 72 <211> 228 <212> PRT <213> rat coronavirus <220> <221> MISC_FEATURE <223> ORF M <400> 72 Met Ser Ser Thr Thr Pro Ala Pro Gln Thr Val Tyr Gln Trp Thr Ala 1 5 10 15 Asp Val Ala Val Arg Phe Leu Lys Glu Trp Asn Phe Leu Leu Gly Ile 20 25 30 Ile Leu Leu Phe Ile Thr Ile Ile Leu Gln Phe Gly Tyr Thr Ser Arg 35 40 45 Ser Met Phe Ile Tyr Val Val Lys Met Ile Ile Leu Trp Leu Met Trp 50 55 60 Pro Leu Thr Ile Val Leu Cys Ile Phe Asn Cys Val Tyr Ala Leu Asn 65 70 75 80 Asn Val Tyr Leu Gly Phe Ser Ile Val Phe Thr Ile Val Ser Ile Val 85 90 95 Met Trp Ile Met Tyr Phe Val Asn Ser Ile Arg Leu Phe Ile Arg Thr 100 105 110 Gly Ser Trp Trp Ser Phe Asn Pro Glu Thr Asn Asn Leu Met Cys Ile 115 120 125 Asp Val Lys Gly Thr Val Tyr Val Arg Pro Ile Ile Glu Asp Tyr His 130 135 140 Thr Leu Thr Ala Thr Asn Val Arg Gly His Leu Tyr Met Gln Gly Val 145 150 155 160 Lys Leu Gly Thr Gly Phe Ser Leu Ser Asp Leu Pro Ala Tyr Val Thr 165 170 175 Val Ala Lys Val Ser His Leu Cys Thr Tyr Lys Arg Ala Phe Leu Asp 180 185 190 Lys Val Asp Gly Val Ser Gly Phe Ala Val Tyr Val Lys Ser Lys Val 195 200 205 Gly Asn Tyr Arg Leu Pro Ser Asn Lys Pro Ser Gly Ala Asp Thr Ala 210 215 220 Leu Leu Arg Ile 225 <210> 73 <211> 221 <212> PRT <213> human SARS virus <220> <221> MISC_FEATURE <223> ORF M <400> 73 Met Ala Asp Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Gln Leu Leu 1 5 10 15 Glu Gln Trp Asn Leu Val Ile Gly Phe Leu Phe Leu Ala Trp Ile Met 20 25 30 Leu Leu Gln Phe Ala Tyr Ser Asn Arg Asn Arg Phe Leu Tyr Ile Ile 35 40 45 Lys Leu Val Phe Leu Trp Leu Leu Trp Pro Val Thr Leu Ala Cys Phe 50 55 60 Val Leu Ala Ala Val Tyr Arg Ile Asn Trp Val Thr Gly Gly Ile Ala 65 70 75 80 Ile Ala Met Ala Cys Ile Val Gly Leu Met Trp Leu Ser Tyr Phe Val 85 90 95 Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe Asn 100 105 110 Pro Glu Thr Asn Ile Leu Leu Asn Val Pro Leu Arg Gly Thr Ile Val 115 120 125 Thr Arg Pro Leu Met Glu Ser Glu Leu Val Ile Gly Ala Val Ile Ile 130 135 140 Arg Gly His Leu Arg Met Ala Gly His Pro Leu Gly Arg Cys Asp Ile 145 150 155 160 Lys Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu Ser 165 170 175 Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Gly Thr Asp Ser Gly Phe 180 185 190 Ala Ala Tyr Asn Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr Asp 195 200 205 His Ala Gly Ser Asn Asp Asn Ile Ala Leu Leu Val Gln 210 215 220 <210> 74 <211> 225 <212> PRT <213> human coronavirus 229E <220> <221> MISC_FEATURE <223> ORF M <400> 74 Met Ser Asn Asp Asn Cys Thr Gly Asp Ile Val Thr His Leu Lys Asn 1 5 10 15 Trp Asn Phe Gly Trp Asn Val Ile Leu Thr Ile Phe Ile Val Ile Leu 20 25 30 Gln Phe Gly His Tyr Lys Tyr Ser Arg Leu Phe Tyr Gly Leu Lys Met 35 40 45 Leu Val Leu Trp Leu Leu Trp Pro Leu Val Leu Ala Leu Ser Ile Phe 50 55 60 Asp Thr Trp Ala Asn Trp Asp Ser Asn Trp Ala Phe Val Ala Phe Ser 65 70 75 80 Phe Phe Met Ala Val Ser Thr Leu Val Met Trp Val Met Tyr Phe Ala 85 90 95 Asn Ser Phe Arg Leu Phe Arg Arg Ala Arg Thr Phe Trp Ala Trp Asn 100 105 110 Pro Glu Val Asn Ala Ile Thr Val Thr Thr Val Leu Gly Gln Thr Tyr 115 120 125 Tyr Gln Pro Ile Gln Gln Ala Pro Thr Gly Ile Thr Val Thr Leu Leu 130 135 140 Ser Gly Val Leu Tyr Val Asp Gly His Arg Leu Ala Ser Gly Val Gln 145 150 155 160 Val His Asn Leu Pro Glu Tyr Met Thr Val Ala Val Pro Ser Thr Thr 165 170 175 Ile Ile Tyr Ser Arg Val Gly Arg Ser Val Asn Ser Gln Asn Ser Thr 180 185 190 Gly Trp Val Phe Tyr Val Arg Val Lys His Gly Asp Phe Ser Ala Val 195 200 205 Ser Ser Pro Met Ser Asn Met Thr Glu Asn Glu Arg Leu Leu His Phe 210 215 220 Phe 225 <210> 75 <211> 382 <212> PRT <213> transmissible gastroenteritis virus <220> <221> MISC_FEATURE <223> ORF N <400> 75 Met Ala Asn Gln Gly Gln Arg Val Ser Trp Gly Asp Glu Ser Thr Lys 1 5 10 15 Thr Arg Gly Arg Ser Asn Ser Arg Gly Arg Lys Asn Asn Asn Ile Pro 20 25 30 Leu Ser Phe Phe Asn Pro Ile Thr Leu Gln Gln Gly Ser Lys Phe Trp 35 40 45 Asn Leu Cys Pro Arg Asp Phe Val Pro Lys Gly Ile Gly Asn Arg Asp 50 55 60 Gln Gln Ile Gly Tyr Trp Asn Arg Gln Thr Arg Tyr Arg Met Val Lys 65 70 75 80 Gly Gln Arg Lys Glu Leu Pro Glu Arg Trp Phe Phe Tyr Tyr Leu Gly 85 90 95 Thr Gly Pro His Ala Asp Ala Lys Phe Lys Asp Lys Leu Asp Gly Val 100 105 110 Val Trp Val Ala Lys Asp Gly Ala Met Asn Lys Pro Thr Thr Leu Gly 115 120 125 Ser Arg Gly Ala Asn Asn Glu Ser Lys Ala Leu Lys Phe Asp Gly Lys 130 135 140 Val Pro Gly Glu Phe Gln Leu Glu Val Asn Gln Ser Arg Asp Asn Ser 145 150 155 160 Arg Ser Arg Ser Gln Ser Arg Ser Arg Ser Arg Asn Arg Ser Gln Ser 165 170 175 Arg Gly Arg Gln Gln Phe Asn Asn Lys Lys Asp Asp Ser Val Glu Gln 180 185 190 Ala Val Leu Ala Ala Leu Lys Lys Leu Gly Val Asp Thr Glu Lys Gln 195 200 205 Gln Gln Arg Ser Arg Ser Lys Ser Lys Glu Arg Ser Asn Ser Lys Thr 210 215 220 Arg Asp Thr Thr Pro Lys Asn Glu Asn Lys His Thr Trp Lys Arg Thr 225 230 235 240 Ala Gly Lys Gly Asp Val Thr Arg Phe Tyr Gly Ala Arg Ser Ser Ser 245 250 255 Ala Asn Phe Gly Asp Thr Asp Leu Val Ala Asn Gly Ser Ser Ala Lys 260 265 270 His Tyr Pro Gln Leu Ala Glu Cys Val Pro Ser Val Ser Ser Ile Leu 275 280 285 Phe Gly Ser Tyr Trp Thr Ser Lys Glu Asp Gly Asp Gln Ile Glu Val 290 295 300 Thr Phe Thr His Lys Tyr His Leu Pro Lys Asp Asp Pro Lys Thr Gly 305 310 315 320 Gln Phe Leu Gln Gln Ile Asn Ala Tyr Ala Arg Pro Ser Glu Val Ala 325 330 335 Lys Glu Gln Arg Lys Arg Lys Ser Arg Ser Lys Ser Ala Glu Arg Ser 340 345 350 Glu Gln Asp Val Val Pro Asp Ala Leu Ile Glu Asn Tyr Thr Asp Val 355 360 365 Phe Asp Asp Thr Gln Val Glu Ile Ile Asp Glu Val Thr Asn 370 375 380 <210> 76 <211> 381 <212> PRT <213> canine coronavirus <220> <221> MISC_FEATURE <223> ORF N <400> 76 Met Ala Ser Gln Gly Gln Arg Val Ser Trp Gly Asp Glu Ser Thr Lys 1 5 10 15 Arg Arg Gly Arg Ser Asn Ser Arg Gly Arg Lys Asn Asn Asp Ile Pro 20 25 30 Leu Ser Phe Phe Asn Pro Ile Thr Leu Glu Gln Gly Ser Lys Phe Trp 35 40 45 Asp Leu Cys Pro Arg Asp Phe Val Pro Lys Gly Ile Gly Asn Lys Asp 50 55 60 Gln Gln Ile Gly Tyr Trp Asn Arg Gln Thr Arg Tyr Arg Met Val Lys 65 70 75 80 Gly Arg Arg Lys Asn Leu Pro Glu Lys Trp Phe Phe Tyr Tyr Leu Gly 85 90 95 Thr Gly Pro His Ala Asp Ala Lys Phe Lys Gln Lys Leu Asp Gly Val 100 105 110 Val Trp Val Ala Arg Gly Asp Ser Met Thr Lys Pro Thr Thr Leu Gly 115 120 125 Thr Arg Gly Thr Asn Asn Glu Ser Lys Ala Leu Lys Phe Asp Val Lys 130 135 140 Val Pro Ser Glu Phe His Leu Glu Val Asn Gln Leu Arg Asp Asn Ser 145 150 155 160 Arg Ser Arg Ser Gln Ser Arg Ser Gln Ser Arg Asn Arg Ser Gln Ser 165 170 175 Arg Gly Arg Gln Leu Ser Asn Asn Lys Lys Asp Asp Asn Val Glu Gln 180 185 190 Ala Val Leu Ala Ala Leu Lys Lys Leu Gly Val Asp Thr Glu Lys Gln 195 200 205 Gln Arg Ser Arg Ser Lys Ser Lys Glu Arg Ser Ser Ser Lys Thr Arg 210 215 220 Asp Thr Thr Pro Lys Asn Glu Asn Lys His Thr Trp Lys Arg Thr Ala 225 230 235 240 Gly Lys Gly Asp Val Thr Lys Phe Tyr Gly Ala Arg Ser Ser Ser Ala 245 250 255 Asn Phe Gly Asp Ser Asp Leu Val Ala Asn Gly Asn Gly Ala Lys His 260 265 270 Tyr Pro Gln Leu Ala Glu Cys Val Pro Ser Val Ser Ser Ile Leu Phe 275 280 285 Gly Ser His Trp Thr Ala Lys Glu Asp Gly Asp Gln Ile Glu Val Thr 290 295 300 Phe Thr His Lys Tyr His Leu Pro Lys Asp Asp Pro Lys Thr Gly Gln 305 310 315 320 Phe Leu Gln Gln Ile Asn Ala Tyr Ala Arg Pro Ser Glu Val Ala Lys 325 330 335 Glu Gln Arg Gln Arg Lys Ala Arg Ser Lys Ser Val Glu Arg Val Glu 340 345 350 Gln Glu Val Val Pro Asp Ala Leu Thr Glu Asn Tyr Thr Asp Val Phe 355 360 365 Asp Asp Thr Gln Val Glu Ile Ile Asp Glu Val Thr Asn 370 375 380 <210> 77 <211> 377 <212> PRT <213> EMCR coronavirus <220> <221> MISC_FEATURE <223> ORF N <400> 77 Met Ala Ser Val Asn Trp Ala Asp Asp Arg Ala Ala Arg Lys Lys Phe 1 5 10 15 Pro Pro Pro Ser Phe Tyr Met Pro Leu Leu Val Ser Ser Asp Lys Ala 20 25 30 Pro Tyr Arg Val Ile Pro Arg Asn Leu Val Pro Ile Gly Lys Gly Asn 35 40 45 Lys Asp Glu Gln Ile Gly Tyr Trp Asn Val Gln Glu Arg Trp Arg Met 50 55 60 Arg Arg Gly Gln Arg Val Asp Leu Pro Pro Lys Val His Phe Tyr Tyr 65 70 75 80 Leu Gly Thr Gly Pro His Lys Asp Leu Lys Phe Arg Gln Arg Ser Asp 85 90 95 Gly Val Val Trp Val Ala Lys Glu Gly Ala Lys Thr Val Asn Thr Ser 100 105 110 Leu Gly Asn Arg Lys Arg Asn Gln Lys Pro Leu Glu Pro Lys Phe Ser 115 120 125 Ile Ala Leu Pro Pro Glu Leu Ser Val Val Glu Phe Glu Asp Arg Ser 130 135 140 Asn Asn Ser Ser Arg Ala Ser Ser Arg Ser Ser Thr Arg Asn Asn Ser 145 150 155 160 Arg Asp Ser Ser Arg Ser Thr Ser Arg Gln Gln Ser Arg Thr Arg Ser 165 170 175 Asp Ser Asn Gln Ser Ser Ser Asp Leu Val Ala Ala Val Thr Leu Ala 180 185 190 Leu Lys Asn Leu Gly Phe Asp Asn Gln Ser Lys Ser Pro Ser Ser Ser 195 200 205 Gly Thr Ser Thr Pro Lys Lys Pro Asn Lys Pro Leu Ser Gln Pro Arg 210 215 220 Ala Asp Lys Pro Ser Gln Leu Lys Lys Pro Arg Trp Lys Arg Val Pro 225 230 235 240 Thr Arg Glu Glu Asn Val Ile Gln Cys Phe Gly Pro Arg Asp Phe Asn 245 250 255 His Asn Met Gly Asp Ser Asp Leu Val Gln Asn Gly Val Asp Ala Lys 260 265 270 Gly Phe Pro Gln Leu Ala Glu Leu Ile Pro Asn Gln Ala Ala Leu Phe 275 280 285 Phe Asp Ser Glu Val Ser Thr Asp Glu Val Gly Asp Asn Val Gln Ile 290 295 300 Thr Tyr Thr Tyr Lys Met Leu Val Ala Lys Asp Asn Lys Asn Leu Pro 305 310 315 320 Lys Phe Ile Glu Gln Ile Ser Ala Phe Thr Lys Pro Ser Ser Ile Lys 325 330 335 Glu Met Gln Ser Gln Ser Ser His Val Ala Gln Asn Thr Val Leu Asn 340 345 350 Ala Ser Ile Pro Glu Ser Lys Pro Leu Ala Asp Asp Asp Ser Ala Ile 355 360 365 Ile Glu Ile Val Asn Glu Val Leu His 370 375 <210> 78 <211> 377 <212> PRT <213> feline coronavirus <220> <221> MISC_FEATURE <223> ORF N <400> 78 Met Ala Thr Gln Gly Gln Arg Val Asn Trp Gly Asp Glu Pro Ser Lys 1 5 10 15 Arg Arg Gly Arg Ser Asn Ser Arg Gly Arg Lys Asn Asn Asp Ile Pro 20 25 30 Leu Ser Phe Tyr Asn Pro Ile Thr Leu Glu Gln Gly Ser Lys Phe Trp 35 40 45 Asn Leu Cys Pro Arg Asp Leu Val Pro Lys Gly Ile Gly Asn Lys Asp 50 55 60 Gln Gln Ile Gly Tyr Trp Asn Arg Gln Ile Arg Tyr Arg Ile Val Lys 65 70 75 80 Gly Gln Arg Lys Glu Leu Ala Glu Arg Trp Phe Phe Tyr Phe Leu Gly 85 90 95 Thr Gly Pro His Ala Asp Ala Lys Phe Lys Asp Lys Ile Asp Gly Val 100 105 110 Phe Trp Val Ala Arg Asp Gly Ala Met Asn Lys Pro Thr Thr Leu Gly 115 120 125 Thr Arg Gly Thr Asn Asn Glu Ser Lys Pro Leu Arg Phe Asp Gly Lys 130 135 140 Ile Pro Pro Gln Phe Gln Leu Glu Val Asn Arg Ser Arg Asn Asn Ser 145 150 155 160 Arg Ser Gly Ser Gln Ser Arg Ser Val Ser Arg Asn Arg Ser Gln Ser 165 170 175 Arg Gly Arg His His Ser Asn Asn Gln Asn Asn Asn Val Glu Asp Thr 180 185 190 Ile Val Ala Val Leu Glu Lys Leu Gly Val Thr Asp Lys Gln Arg Ser 195 200 205 Arg Ser Lys Pro Arg Glu Arg Ser Asp Ser Lys Pro Arg Asp Thr Thr 210 215 220 Pro Lys Asn Ala Asn Lys His Thr Trp Lys Lys Thr Ala Gly Lys Gly 225 230 235 240 Asp Val Thr Thr Phe Tyr Gly Ala Arg Ser Ser Ser Ala Asn Phe Gly 245 250 255 Asp Ser Asp Leu Val Ala Asn Gly Asn Ala Ala Lys Cys Tyr Pro Gln 260 265 270 Ile Ala Glu Cys Val Pro Ser Val Ser Ser Ile Ile Phe Gly Ser Gln 275 280 285 Trp Ser Ala Glu Glu Ala Gly Asp Gln Val Lys Val Thr Leu Thr His 290 295 300 Thr Tyr Tyr Leu Pro Lys Asp Asp Ala Lys Thr Ser Gln Phe Leu Glu 305 310 315 320 Gln Ile Asp Ala Tyr Lys Arg Pro Ser Glu Val Ala Lys Asp Gln Arg 325 330 335 Gln Arg Arg Ser Arg Ser Lys Ser Ala Asp Lys Lys Pro Glu Glu Leu 340 345 350 Ser Val Thr Leu Val Glu Ala Tyr Thr Asp Val Phe Asp Asp Thr Gln 355 360 365 Val Glu Met Ile Asp Glu Val Thr Asn 370 375 <210> 79 <211> 441 <212> PRT <213> porcine epidemic diahrrea virus <220> <221> MISC_FEATURE <223> ORF N <400> 79 Met Ala Ser Val Ser Phe Gln Asp Arg Gly Arg Lys Arg Val Pro Leu 1 5 10 15 Ser Leu Tyr Ala Pro Leu Arg Val Thr Asn Asp Lys Pro Leu Ser Lys 20 25 30 Val Leu Ala Asn Asn Ala Val Pro Thr Asn Lys Gly Asn Lys Asp Gln 35 40 45 Gln Ile Gly Tyr Trp Asn Glu Gln Ile Arg Trp Arg Met Arg Arg Gly 50 55 60 Glu Arg Ile Glu Gln Pro Ser Asn Trp His Phe Tyr Tyr Leu Gly Thr 65 70 75 80 Gly Pro His Gly Asp Leu Arg Tyr Arg Thr Arg Thr Glu Gly Val Phe 85 90 95 Trp Val Ala Lys Glu Gly Ala Lys Thr Glu Pro Thr Asn Leu Gly Val 100 105 110 Arg Lys Ala Ser Glu Lys Pro Ile Ile Pro Lys Phe Ser Gln Gln Leu 115 120 125 Pro Ser Val Val Glu Ile Val Glu Pro Asn Thr Pro Pro Ala Ser Arg 130 135 140 Ala Asn Ser Arg Ser Arg Ser Arg Gly Asn Gly Asn Asn Arg Ser Arg 145 150 155 160 Ser Pro Ser Asn Asn Arg Gly Asn Asn Gln Ser Arg Gly Asn Ser Gln 165 170 175 Asn Arg Gly Asn Asn Gln Gly Arg Gly Ala Ser Gln Asn Arg Gly Gly 180 185 190 Asn Asn Asn Asn Asn Asn Lys Ser Arg Asn Gln Ser Asn Asn Arg Asn 195 200 205 Gln Ser Asn Asp Arg Gly Gly Val Thr Ser Arg Asp Asp Leu Val Ala 210 215 220 Ala Val Lys Asp Ala Leu Lys Ser Leu Gly Ile Gly Glu Asn Pro Asp 225 230 235 240 Arg His Lys Gln Gln Gln Lys Pro Lys Gln Glu Lys Ser Asp Asn Ser 245 250 255 Gly Lys Asn Thr Pro Lys Lys Asn Lys Ser Arg Ala Thr Ser Lys Glu 260 265 270 Arg Asp Leu Lys Asp Ile Pro Glu Trp Arg Arg Ile Pro Lys Gly Glu 275 280 285 Asn Ser Val Ala Ala Cys Phe Gly Pro Arg Gly Gly Phe Lys Asn Phe 290 295 300 Gly Asp Ala Glu Phe Val Glu Lys Gly Val Asp Ala Ser Gly Tyr Ala 305 310 315 320 Gln Ile Ala Ser Leu Ala Pro Asn Val Ala Ala Leu Leu Phe Gly Gly 325 330 335 Asn Val Ala Val Arg Glu Leu Ala Asp Ser Tyr Glu Ile Thr Tyr Asn 340 345 350 Tyr Lys Met Thr Val Pro Lys Ser Asp Pro Asn Val Glu Leu Leu Val 355 360 365 Ser Gln Val Asp Ala Phe Lys Thr Gly Asn Ala Lys Leu Gln Arg Lys 370 375 380 Lys Glu Lys Lys Asn Lys Arg Glu Thr Thr Leu Gln Gln His Glu Glu 385 390 395 400 Ala Ile Tyr Asp Asp Val Gly Ala Pro Ser Asp Val Thr His Ala Asn 405 410 415 Leu Glu Trp Asp Thr Ala Val Asp Gly Gly Asp Thr Ala Val Glu Ile 420 425 430 Ile Asn Glu Ile Phe Asp Thr Gly Asn 435 440 <210> 80 <211> 382 <212> PRT <213> porcine respiratory coronavirus <220> <221> MISC_FEATURE <223> ORF N <400> 80 Met Ala Asn Gln Gly Gln Arg Val Ser Trp Gly Asp Glu Ser Thr Lys 1 5 10 15 Ile Arg Gly Arg Ser Asn Ser Arg Gly Arg Lys Ile Asn Asn Ile Pro 20 25 30 Leu Ser Phe Phe Asn Pro Ile Thr Leu Gln Gln Gly Ala Lys Phe Trp 35 40 45 Asn Ser Cys Pro Arg Asp Phe Val Pro Lys Gly Ile Gly Asn Arg Asp 50 55 60 Gln Gln Ile Gly Tyr Trp Asn Arg Gln Thr Arg Tyr Arg Met Val Lys 65 70 75 80 Gly Gln Arg Lys Glu Leu Pro Glu Arg Trp Phe Phe Tyr Tyr Leu Gly 85 90 95 Thr Gly Pro His Ala Asp Ala Lys Phe Lys Asp Lys Leu Asp Gly Val 100 105 110 Val Trp Val Ala Lys Asp Gly Ala Met Asn Lys Pro Thr Thr Leu Gly 115 120 125 Ser Arg Gly Ala Asn Asn Glu Ser Lys Ala Leu Lys Phe Asp Gly Lys 130 135 140 Val Pro Gly Glu Phe Gln Leu Glu Val Asn Gln Ser Arg Asp Asn Ser 145 150 155 160 Arg Ser Arg Ser Gln Ser Arg Ser Arg Ser Arg Asn Arg Ser Gln Ser 165 170 175 Arg Gly Arg Gln Gln Ser Asn Asn Lys Lys Asp Asp Ser Val Glu Gln 180 185 190 Ala Val Leu Ala Ala Leu Lys Lys Leu Gly Val Tyr Thr Glu Lys Gln 195 200 205 Gln Gln Arg Ser Arg Ser Lys Ser Lys Glu Arg Ser Asn Ser Lys Thr 210 215 220 Arg Asp Thr Thr Pro Lys Asn Glu Asn Lys His Thr Trp Lys Arg Thr 225 230 235 240 Ala Gly Lys Gly Asp Val Thr Arg Phe Tyr Gly Ala Arg Ser Ser Ser 245 250 255 Ala Asn Phe Gly Asp Ser Asp Leu Val Ala Asn Gly Ser Ser Ala Lys 260 265 270 His Tyr Pro Gln Leu Ala Glu Cys Val Pro Ser Val Ser Ser Ile Leu 275 280 285 Phe Gly Ser Tyr Trp Thr Ser Lys Glu Asp Gly Asp Gln Ile Glu Val 290 295 300 Thr Phe Thr His Lys Tyr His Leu Pro Lys Asp His Pro Lys Thr Glu 305 310 315 320 Gln Phe Leu Gln Gln Ile Asn Ala Tyr Ala Ser Pro Ser Glu Leu Ala 325 330 335 Lys Glu Gln Arg Lys Arg Lys Ser Arg Ser Lys Ser Ala Glu Arg Ser 340 345 350 Glu Gln Glu Val Val Pro Asp Ser Leu Ile Glu Asn Tyr Thr Asp Val 355 360 365 Phe Asp Asp Thr Gln Val Glu Met Ile Asp Glu Val Thr Asn 370 375 380 <210> 81 <211> 454 <212> PRT <213> rat coronavirus <220> <221> MISC_FEATURE <223> ORF N <400> 81 Met Ser Phe Val Pro Gly Gln Glu Asn Ala Gly Ser Arg Ser Ser Ser 1 5 10 15 Gly Asn Arg Ala Gly Asn Gly Ile Leu Lys Lys Thr Thr Trp Ala Asp 20 25 30 Gln Thr Glu Arg Gly Gln Asn Asn Gly Asn Arg Gly Arg Arg Asn Gln 35 40 45 Pro Lys Gln Thr Ala Thr Thr Gln Pro Asn Thr Gly Ser Val Val Pro 50 55 60 His Tyr Ser Trp Phe Ser Gly Ile Thr Gln Phe Gln Lys Gly Lys Glu 65 70 75 80 Phe Gln Phe Ala Gly Gly Gln Gly Val Pro Ile Ala Asn Gly Ile Pro 85 90 95 Pro Ser Glu Gln Lys Gly Tyr Trp Tyr Arg His Asn Arg Arg Ser Phe 100 105 110 Lys Thr Pro Asp Gly Gln Gln Lys Gln Leu Leu Pro Arg Trp Tyr Phe 115 120 125 Tyr Tyr Leu Gly Thr Gly Pro His Ala Gly Ala Ser Phe Gly Asp Ser 130 135 140 Ile Glu Gly Val Phe Trp Val Ala Asn Ser Gln Ala Asp Thr Asn Thr 145 150 155 160 Ser Ala Asp Ile Val Glu Arg Asp Pro Ser Ser His Glu Ala Ile Pro 165 170 175 Thr Arg Phe Ala Pro Gly Thr Val Leu Pro Gln Gly Phe Tyr Val Glu 180 185 190 Gly Ser Gly Arg Ser Ala Pro Ala Ser Arg Ser Gly Ser Arg Ser Gln 195 200 205 Ser Arg Gly Pro Asn Asn Arg Ala Arg Ser Ser Ser Asn Gln Arg Gln 210 215 220 Pro Ala Ser Thr Val Lys Pro Asp Met Ala Glu Glu Ile Ala Ala Leu 225 230 235 240 Val Leu Ala Asn Leu Gly Lys Asp Ala Gly Gln Pro Lys Gln Val Thr 245 250 255 Lys Gln Ser Ala Lys Glu Val Arg Gln Lys Ile Leu Asn Lys Pro Arg 260 265 270 Gln Lys Arg Thr Pro Asn Lys Gln Cys Pro Val Gln Gln Cys Phe Gly 275 280 285 Lys Arg Gly Pro Asn Gln Asn Phe Gly Gly Pro Glu Met Leu Lys Leu 290 295 300 Gly Thr Ser Asp Pro Gln Phe Pro Ile Leu Ala Glu Leu Ala Pro Thr 305 310 315 320 Pro Gly Ala Phe Phe Phe Gly Ser Lys Leu Glu Leu Val Lys Lys Asn 325 330 335 Ser Gly Gly Val Asp Glu Pro Thr Lys Asp Val Tyr Glu Leu Gln Tyr 340 345 350 Ser Gly Ala Val Arg Phe Asp Ser Thr Leu Pro Gly Phe Glu Thr Ile 355 360 365 Met Lys Val Leu Asn Glu Asn Leu Asn Ala Tyr Gln Asn Gln Ala Gly 370 375 380 Gly Ala Asp Val Val Ser Pro Lys Pro Gln Arg Lys Arg Gly Thr Lys 385 390 395 400 Gln Thr Ala Gln Lys Glu Glu Leu Asp Ser Ile Ser Val Ala Lys Pro 405 410 415 Lys Ser Ala Val Gln Arg Asn Val Ser Arg Glu Leu Thr Pro Glu Asp 420 425 430 Arg Ser Leu Leu Ala Gln Ile Leu Asp Asp Gly Val Val Pro Asp Gly 435 440 445 Leu Asp Asp Ser Asn Val 450 <210> 82 <211> 389 <212> PRT <213> human coronavirus 229E <220> <221> MISC_FEATURE <223> ORF N <400> 82 Met Ala Thr Val Lys Trp Ala Asp Ala Ser Glu Pro Gln Arg Gly Arg 1 5 10 15 Gln Gly Arg Ile Pro Tyr Ser Leu Tyr Ser Pro Leu Leu Val Asp Ser 20 25 30 Glu Gln Pro Trp Lys Val Ile Pro Arg Asn Leu Val Pro Ile Asn Lys 35 40 45 Lys Asp Lys Asn Lys Leu Ile Gly Tyr Trp Asn Val Gln Lys Arg Phe 50 55 60 Arg Thr Arg Lys Gly Lys Arg Val Asp Leu Ser Pro Lys Leu His Phe 65 70 75 80 Tyr Tyr Leu Gly Thr Gly Pro His Lys Asp Ala Lys Phe Arg Glu Arg 85 90 95 Val Glu Gly Val Val Trp Val Ala Val Asp Gly Ala Lys Thr Glu Pro 100 105 110 Thr Gly Tyr Gly Val Arg Arg Lys Asn Ser Glu Pro Glu Ile Pro His 115 120 125 Phe Asn Gln Lys Leu Pro Asn Gly Val Thr Val Val Glu Glu Pro Asp 130 135 140 Ser Arg Ala Pro Ser Arg Ser Gln Ser Arg Ser Gln Ser Arg Gly Arg 145 150 155 160 Gly Glu Ser Lys Pro Gln Ser Arg Asn Pro Ser Ser Asp Arg Asn His 165 170 175 Asn Ser Gln Asp Asp Ile Met Lys Ala Val Ala Ala Ala Leu Lys Ser 180 185 190 Leu Gly Phe Asp Lys Pro Gln Glu Lys Asp Lys Lys Ser Ala Lys Thr 195 200 205 Gly Thr Pro Lys Pro Ser Arg Asn Gln Ser Pro Ala Ser Ser Gln Thr 210 215 220 Ser Ala Lys Ser Leu Ala Arg Ser Gln Ser Ser Glu Thr Lys Glu Gln 225 230 235 240 Lys His Glu Met Gln Lys Pro Arg Trp Lys Arg Gln Pro Asn Asp Asp 245 250 255 Val Thr Ser Asn Val Thr Gln Cys Phe Gly Pro Arg Asp Leu Asp His 260 265 270 Asn Phe Gly Ser Ala Gly Val Val Ala Asn Gly Val Lys Ala Lys Gly 275 280 285 Tyr Pro Gln Phe Ala Glu Leu Val Pro Ser Thr Ala Ala Met Leu Phe 290 295 300 Asp Ser His Ile Val Ser Lys Glu Ser Gly Asn Thr Val Val Leu Thr 305 310 315 320 Phe Thr Thr Arg Val Thr Val Pro Lys Asp His Pro His Leu Gly Lys 325 330 335 Phe Leu Glu Glu Leu Asn Ala Phe Thr Arg Glu Met Gln Gln His Pro 340 345 350 Leu Leu Asn Pro Ser Ala Leu Glu Phe Asn Pro Ser Gln Thr Ser Pro 355 360 365 Ala Thr Ala Glu Pro Val Arg Asp Glu Val Ser Ile Glu Thr Asp Ile 370 375 380 Ile Asp Glu Val Asn 385 <210> 83 <211> 264 <212> DNA <213> EMCR Coronavirus <220> <221> 5'UTR <222> (1)..(264) <400> 83 agatagagaa ttttcttatt tagactttgt gtctactcct ctcaactaaa cgaaattttt 60 ctagtgctgt catttgttat ggcagtccta gtgtaattga aatttcgtca agtttgtaaa 120 ctggttaggc aagtgttgta ttttctgtgt ttaagcactg gtggttctgt ccactagtgc 180 acacattgat acttaagtgg tgttctgtca ctgcttattg tggaagcaac gttctgtcgt 240 tgtggaaacc aataactgct aacc 264 <210> 84 <211> 2685 <212> PRT <213> human SARS virus <220> <221> MISC_FEATURE <223> ORF 1B <400> 84 Thr Pro Cys Gly Thr Gly Thr Ser Thr Asp Val Val Tyr Arg Ala Phe 1 5 10 15 Asp Ile Tyr Asn Glu Lys Val Ala Gly Phe Ala Lys Phe Leu Lys Thr 20 25 30 Asn Cys Cys Arg Phe Gln Glu Lys Asp Glu Glu Gly Asn Leu Leu Asp 35 40 45 Ser Tyr Phe Val Val Lys Arg His Thr Met Ser Asn Tyr Gln His Glu 50 55 60 Glu Thr Ile Tyr Asn Leu Val Lys Asp Cys Pro Ala Val Ala Val His 65 70 75 80 Asp Phe Phe Lys Phe Arg Val Asp Gly Asp Met Val Pro His Ile Ser 85 90 95 Arg Gln Arg Leu Thr Lys Tyr Thr Met Ala Asp Leu Val Tyr Ala Leu 100 105 110 Arg His Phe Asp Glu Gly Asn Cys Asp Thr Leu Lys Glu Ile Leu Val 115 120 125 Thr Tyr Asn Cys Cys Asp Asp Asp Tyr Phe Asn Lys Lys Asp Trp Tyr 130 135 140 Asp Phe Val Glu Asn Pro Asp Ile Leu Arg Val Tyr Ala Asn Leu Gly 145 150 155 160 Glu Arg Val Arg Gln Ser Leu Leu Lys Thr Val Gln Phe Cys Asp Ala 165 170 175 Met Arg Asp Ala Gly Ile Val Gly Val Leu Thr Leu Asp Asn Gln Asp 180 185 190 Leu Asn Gly Asn Trp Tyr Asp Phe Gly Asp Phe Val Gln Val Ala Pro 195 200 205 Gly Cys Gly Val Pro Ile Val Asp Ser Tyr Tyr Ser Leu Leu Met Pro 210 215 220 Ile Leu Thr Leu Thr Arg Ala Leu Ala Ala Glu Ser His Met Asp Ala 225 230 235 240 Asp Leu Ala Lys Pro Leu Ile Lys Trp Asp Leu Leu Lys Tyr Asp Phe 245 250 255 Thr Glu Glu Arg Leu Cys Leu Phe Asp Arg Tyr Phe Lys Tyr Trp Asp 260 265 270 Gln Thr Tyr His Pro Asn Cys Ile Asn Cys Leu Asp Asp Arg Cys Ile 275 280 285 Leu His Cys Ala Asn Phe Asn Val Leu Phe Ser Thr Val Phe Pro Pro 290 295 300 Thr Ser Phe Gly Pro Leu Val Arg Lys Ile Phe Val Asp Gly Val Pro 305 310 315 320 Phe Val Val Ser Thr Gly Tyr His Phe Arg Glu Leu Gly Val Val His 325 330 335 Asn Gln Asp Val Asn Leu His Ser Ser Arg Leu Ser Phe Lys Glu Leu 340 345 350 Leu Val Tyr Ala Ala Asp Pro Ala Met His Ala Ala Ser Gly Asn Leu 355 360 365 Leu Leu Asp Lys Arg Thr Thr Cys Phe Ser Val Ala Ala Leu Thr Asn 370 375 380 Asn Val Ala Phe Gln Thr Val Lys Pro Gly Asn Phe Asn Lys Asp Phe 385 390 395 400 Tyr Asp Phe Ala Val Ser Lys Gly Phe Phe Lys Glu Gly Ser Ser Val 405 410 415 Glu Leu Lys His Phe Phe Phe Ala Gln Asp Gly Asn Ala Ala Ile Ser 420 425 430 Asp Tyr Asp Tyr Tyr Arg Tyr Asn Leu Pro Thr Met Cys Asp Ile Arg 435 440 445 Gln Leu Leu Phe Val Val Glu Val Val Asp Lys Tyr Phe Asp Cys Tyr 450 455 460 Asp Gly Gly Cys Ile Asn Ala Asn Gln Val Ile Val Asn Asn Leu Asp 465 470 475 480 Lys Ser Ala Gly Phe Pro Phe Asn Lys Trp Gly Lys Ala Arg Leu Tyr 485 490 495 Tyr Asp Ser Met Ser Tyr Glu Asp Gln Asp Ala Leu Phe Ala Tyr Thr 500 505 510 Lys Arg Asn Val Ile Pro Thr Ile Thr Gln Met Asn Leu Lys Tyr Ala 515 520 525 Ile Ser Ala Lys Asn Arg Ala Arg Thr Val Ala Gly Val Ser Ile Cys 530 535 540 Ser Thr Met Thr Asn Arg Gln Phe His Gln Lys Leu Leu Lys Ser Ile 545 550 555 560 Ala Ala Thr Arg Gly Ala Thr Val Val Ile Gly Thr Ser Lys Phe Tyr 565 570 575 Gly Gly Trp His Asn Met Leu Lys Thr Val Tyr Ser Asp Val Glu Thr 580 585 590 Pro His Leu Met Gly Trp Asp Tyr Pro Lys Cys Asp Arg Ala Met Pro 595 600 605 Asn Met Leu Arg Ile Met Ala Ser Leu Val Leu Ala Arg Lys His Asn 610 615 620 Thr Cys Cys Asn Leu Ser His Arg Phe Tyr Arg Leu Ala Asn Glu Cys 625 630 635 640 Ala Gln Val Leu Ser Glu Met Val Met Cys Gly Gly Ser Leu Tyr Val 645 650 655 Lys Pro Gly Gly Thr Ser Ser Gly Asp Ala Thr Thr Ala Tyr Ala Asn 660 665 670 Ser Val Phe Asn Ile Cys Gln Ala Val Thr Ala Asn Val Asn Ala Leu 675 680 685 Leu Ser Thr Asp Gly Asn Lys Ile Ala Asp Lys Tyr Val Arg Asn Leu 690 695 700 Gln His Arg Leu Tyr Glu Cys Leu Tyr Arg Asn Arg Asp Val Asp His 705 710 715 720 Glu Phe Val Asp Glu Phe Tyr Ala Tyr Leu Arg Lys His Phe Ser Met 725 730 735 Met Ile Leu Ser Asp Asp Ala Val Val Cys Tyr Asn Ser Asn Tyr Ala 740 745 750 Ala Gln Gly Leu Val Ala Ser Ile Lys Asn Phe Lys Ala Val Leu Tyr 755 760 765 Tyr Gln Asn Asn Val Phe Met Ser Glu Ala Lys Cys Trp Thr Glu Thr 770 775 780 Asp Leu Thr Lys Gly Pro His Glu Phe Cys Ser Gln His Thr Met Leu 785 790 795 800 Val Lys Gln Gly Asp Asp Tyr Val Tyr Leu Pro Tyr Pro Asp Pro Ser 805 810 815 Arg Ile Leu Gly Ala Gly Cys Phe Val Asp Asp Ile Val Lys Thr Asp 820 825 830 Gly Thr Leu Met Ile Glu Arg Phe Val Ser Leu Ala Ile Asp Ala Tyr 835 840 845 Pro Leu Thr Lys His Pro Asn Gln Glu Tyr Ala Asp Val Phe His Leu 850 855 860 Tyr Leu Gln Tyr Ile Arg Lys Leu His Asp Glu Leu Thr Gly His Met 865 870 875 880 Leu Asp Met Tyr Ser Val Met Leu Thr Asn Asp Asn Thr Ser Arg Tyr 885 890 895 Trp Glu Pro Glu Phe Tyr Glu Ala Met Tyr Thr Pro His Thr Val Leu 900 905 910 Gln Ala Val Gly Ala Cys Val Leu Cys Asn Ser Gln Thr Ser Leu Arg 915 920 925 Cys Gly Ala Cys Ile Arg Arg Pro Phe Leu Cys Cys Lys Cys Cys Tyr 930 935 940 Asp His Val Ile Ser Thr Ser His Lys Leu Val Leu Ser Val Asn Pro 945 950 955 960 Tyr Val Cys Asn Ala Pro Gly Cys Asp Val Thr Asp Val Thr Gln Leu 965 970 975 Tyr Leu Gly Gly Met Ser Tyr Tyr Cys Lys Ser His Lys Pro Pro Ile 980 985 990 Ser Phe Pro Leu Cys Ala Asn Gly Gln Val Phe Gly Leu Tyr Lys Asn 995 1000 1005 Thr Cys Val Gly Ser Asp Asn Val Thr Asp Phe Asn Ala Ile Ala 1010 1015 1020 Thr Cys Asp Trp Thr Asn Ala Gly Asp Tyr Ile Leu Ala Asn Thr 1025 1030 1035 Cys Thr Glu Arg Leu Lys Leu Phe Ala Ala Glu Thr Leu Lys Ala 1040 1045 1050 Thr Glu Glu Thr Phe Lys Leu Ser Tyr Gly Ile Ala Thr Val Arg 1055 1060 1065 Glu Val Leu Ser Asp Arg Glu Leu His Leu Ser Trp Glu Val Gly 1070 1075 1080 Lys Pro Arg Pro Pro Leu Asn Arg Asn Tyr Val Phe Thr Gly Tyr 1085 1090 1095 Arg Val Thr Lys Asn Ser Lys Val Gln Ile Gly Glu Tyr Thr Phe 1100 1105 1110 Glu Lys Gly Asp Tyr Gly Asp Ala Val Val Tyr Arg Gly Thr Thr 1115 1120 1125 Thr Tyr Lys Leu Asn Val Gly Asp Tyr Phe Val Leu Thr Ser His 1130 1135 1140 Thr Val Met Pro Leu Ser Ala Pro Thr Leu Val Pro Gln Glu His 1145 1150 1155 Tyr Val Arg Ile Thr Gly Leu Tyr Pro Thr Leu Asn Ile Ser Asp 1160 1165 1170 Glu Phe Ser Ser Asn Val Ala Asn Tyr Gln Lys Val Gly Met Gln 1175 1180 1185 Lys Tyr Ser Thr Leu Gln Gly Pro Pro Gly Thr Gly Lys Ser His 1190 1195 1200 Phe Ala Ile Gly Leu Ala Leu Tyr Tyr Pro Ser Ala Arg Ile Val 1205 1210 1215 Tyr Thr Ala Cys Ser His Ala Ala Val Asp Ala Leu Cys Glu Lys 1220 1225 1230 Ala Leu Lys Tyr Leu Pro Ile Asp Lys Cys Ser Arg Ile Ile Pro 1235 1240 1245 Ala Arg Ala Arg Val Glu Cys Phe Asp Lys Phe Lys Val Asn Ser 1250 1255 1260 Thr Leu Glu Gln Tyr Val Phe Cys Thr Val Asn Ala Leu Pro Glu 1265 1270 1275 Thr Thr Ala Asp Ile Val Val Phe Asp Glu Ile Ser Met Ala Thr 1280 1285 1290 Asn Tyr Asp Leu Ser Val Val Asn Ala Arg Leu Arg Ala Lys His 1295 1300 1305 Tyr Val Tyr Ile Gly Asp Pro Ala Gln Leu Pro Ala Pro Arg Thr 1310 1315 1320 Leu Leu Thr Lys Gly Thr Leu Glu Pro Glu Tyr Phe Asn Ser Val 1325 1330 1335 Cys Arg Leu Met Lys Thr Ile Gly Pro Asp Met Phe Leu Gly Thr 1340 1345 1350 Cys Arg Arg Cys Pro Ala Glu Ile Val Asp Thr Val Ser Ala Leu 1355 1360 1365 Val Tyr Asp Asn Lys Leu Lys Ala His Lys Asp Lys Ser Ala Gln 1370 1375 1380 Cys Phe Lys Met Phe Tyr Lys Gly Val Ile Thr His Asp Val Ser 1385 1390 1395 Ser Ala Ile Asn Arg Pro Gln Ile Gly Val Val Arg Glu Phe Leu 1400 1405 1410 Thr Arg Asn Pro Ala Trp Arg Lys Ala Val Phe Ile Ser Pro Tyr 1415 1420 1425 Asn Ser Gln Asn Ala Val Ala Ser Lys Ile Leu Gly Leu Pro Thr 1430 1435 1440 Gln Thr Val Asp Ser Ser Gln Gly Ser Glu Tyr Asp Tyr Val Ile 1445 1450 1455 Phe Thr Gln Thr Thr Glu Thr Ala His Ser Cys Asn Val Asn Arg 1460 1465 1470 Phe Asn Val Ala Ile Thr Arg Ala Lys Ile Gly Ile Leu Cys Ile 1475 1480 1485 Met Ser Asp Arg Asp Leu Tyr Asp Lys Leu Gln Phe Thr Ser Leu 1490 1495 1500 Glu Ile Pro Arg Arg Asn Val Ala Thr Leu Gln Ala Glu Asn Val 1505 1510 1515 Thr Gly Leu Phe Lys Asp Cys Ser Lys Ile Ile Thr Gly Leu His 1520 1525 1530 Pro Thr Gln Ala Pro Thr His Leu Ser Val Asp Ile Lys Phe Lys 1535 1540 1545 Thr Glu Gly Leu Cys Val Asp Ile Pro Gly Ile Pro Lys Asp Met 1550 1555 1560 Thr Tyr Arg Arg Leu Ile Ser Met Met Gly Phe Lys Met Asn Tyr 1565 1570 1575 Gln Val Asn Gly Tyr Pro Asn Met Phe Ile Thr Arg Glu Glu Ala 1580 1585 1590 Ile Arg His Val Arg Ala Trp Ile Gly Phe Asp Val Glu Gly Cys 1595 1600 1605 His Ala Thr Arg Asp Ala Val Gly Thr Asn Leu Pro Leu Gln Leu 1610 1615 1620 Gly Phe Ser Thr Gly Val Asn Leu Val Ala Val Pro Thr Gly Tyr 1625 1630 1635 Val Asp Thr Glu Asn Asn Thr Glu Phe Thr Arg Val Asn Ala Lys 1640 1645 1650 Pro Pro Pro Gly Asp Gln Phe Lys His Leu Ile Pro Leu Met Tyr 1655 1660 1665 Lys Gly Leu Pro Trp Asn Val Val Arg Ile Lys Ile Val Gln Met 1670 1675 1680 Leu Ser Asp Thr Leu Lys Gly Leu Ser Asp Arg Val Val Phe Val 1685 1690 1695 Leu Trp Ala His Gly Phe Glu Leu Thr Ser Met Lys Tyr Phe Val 1700 1705 1710 Lys Ile Gly Pro Glu Arg Thr Cys Cys Leu Cys Asp Lys Arg Ala 1715 1720 1725 Thr Cys Phe Ser Thr Ser Ser Asp Thr Tyr Ala Cys Trp Asn His 1730 1735 1740 Ser Val Gly Phe Asp Tyr Val Tyr Asn Pro Phe Met Ile Asp Val 1745 1750 1755 Gln Gln Trp Gly Phe Thr Gly Asn Leu Gln Ser Asn His Asp Gln 1760 1765 1770 His Cys Gln Val His Gly Asn Ala His Val Ala Ser Cys Asp Ala 1775 1780 1785 Ile Met Thr Arg Cys Leu Ala Val His Glu Cys Phe Val Lys Arg 1790 1795 1800 Val Asp Trp Ser Val Glu Tyr Pro Ile Ile Gly Asp Glu Leu Arg 1805 1810 1815 Val Asn Ser Ala Cys Arg Lys Val Gln His Met Val Val Lys Ser 1820 1825 1830 Ala Leu Leu Ala Asp Lys Phe Pro Val Leu His Asp Ile Gly Asn 1835 1840 1845 Pro Lys Ala Ile Lys Cys Val Pro Gln Ala Glu Val Glu Trp Lys 1850 1855 1860 Phe Tyr Asp Ala Gln Pro Cys Ser Asp Lys Ala Tyr Lys Ile Glu 1865 1870 1875 Glu Leu Phe Tyr Ser Tyr Ala Thr His His Asp Lys Phe Thr Asp 1880 1885 1890 Gly Val Cys Leu Phe Trp Asn Cys Asn Val Asp Arg Tyr Pro Ala 1895 1900 1905 Asn Ala Ile Val Cys Arg Phe Asp Thr Arg Val Leu Ser Asn Leu 1910 1915 1920 Asn Leu Pro Gly Cys Asp Gly Gly Ser Leu Tyr Val Asn Lys His 1925 1930 1935 Ala Phe His Thr Pro Ala Phe Asp Lys Ser Ala Phe Thr Asn Leu 1940 1945 1950 Lys Gln Leu Pro Phe Phe Tyr Tyr Ser Asp Ser Pro Cys Glu Ser 1955 1960 1965 His Gly Lys Gln Val Val Ser Asp Ile Asp Tyr Val Pro Leu Lys 1970 1975 1980 Ser Ala Thr Cys Ile Thr Arg Cys Asn Leu Gly Gly Ala Val Cys 1985 1990 1995 Arg His His Ala Asn Glu Tyr Arg Gln Tyr Leu Asp Ala Tyr Asn 2000 2005 2010 Met Met Ile Ser Ala Gly Phe Ser Leu Trp Ile Tyr Lys Gln Phe 2015 2020 2025 Asp Thr Tyr Asn Leu Trp Asn Thr Phe Thr Arg Leu Gln Ser Leu 2030 2035 2040 Glu Asn Val Ala Tyr Asn Val Val Asn Lys Gly His Phe Asp Gly 2045 2050 2055 His Ala Gly Glu Ala Pro Val Ser Ile Ile Asn Asn Ala Val Tyr 2060 2065 2070 Thr Lys Val Asp Gly Ile Asp Val Glu Ile Phe Glu Asn Lys Thr 2075 2080 2085 Thr Leu Pro Val Asn Val Ala Phe Glu Leu Trp Ala Lys Arg Asn 2090 2095 2100 Ile Lys Pro Val Pro Glu Ile Lys Ile Leu Asn Asn Leu Gly Val 2105 2110 2115 Asp Ile Ala Ala Asn Thr Val Ile Trp Asp Tyr Lys Arg Glu Ala 2120 2125 2130 Pro Ala His Val Ser Thr Ile Gly Val Cys Thr Met Thr Asp Ile 2135 2140 2145 Ala Lys Lys Pro Thr Glu Ser Ala Cys Ser Ser Leu Thr Val Leu 2150 2155 2160 Phe Asp Gly Arg Val Glu Gly Gln Val Asp Leu Phe Arg Asn Ala 2165 2170 2175 Arg Asn Gly Val Leu Ile Thr Glu Gly Ser Val Lys Gly Leu Thr 2180 2185 2190 Pro Ser Lys Gly Pro Ala Gln Ala Ser Val Asn Gly Val Thr Leu 2195 2200 2205 Ile Gly Glu Ser Val Lys Thr Gln Phe Asn Tyr Phe Lys Lys Val 2210 2215 2220 Asp Gly Ile Ile Gln Gln Leu Pro Glu Thr Tyr Phe Thr Gln Ser 2225 2230 2235 Arg Asp Leu Glu Asp Phe Lys Pro Arg Ser Gln Met Glu Thr Asp 2240 2245 2250 Phe Leu Glu Leu Ala Met Asp Glu Phe Ile Gln Arg Tyr Lys Leu 2255 2260 2265 Glu Gly Tyr Ala Phe Glu His Ile Val Tyr Gly Asp Phe Ser His 2270 2275 2280 Gly Gln Leu Gly Gly Leu His Leu Met Ile Gly Leu Ala Lys Arg 2285 2290 2295 Ser Gln Asp Ser Pro Leu Lys Leu Glu Asp Phe Ile Pro Met Asp 2300 2305 2310 Ser Thr Val Lys Asn Tyr Phe Ile Thr Asp Ala Gln Thr Gly Ser 2315 2320 2325 Ser Lys Cys Val Cys Ser Val Ile Asp Leu Leu Leu Asp Asp Phe 2330 2335 2340 Val Glu Ile Ile Lys Ser Gln Asp Leu Ser Val Ile Ser Lys Val 2345 2350 2355 Val Lys Val Thr Ile Asp Tyr Ala Glu Ile Ser Phe Met Leu Trp 2360 2365 2370 Cys Lys Asp Gly His Val Glu Thr Phe Tyr Pro Lys Leu Gln Ala 2375 2380 2385 Ser Gln Ala Trp Gln Pro Gly Val Ala Met Pro Asn Leu Tyr Lys 2390 2395 2400 Met Gln Arg Met Leu Leu Glu Lys Cys Asp Leu Gln Asn Tyr Gly 2405 2410 2415 Glu Asn Ala Val Ile Pro Lys Gly Ile Met Met Asn Val Ala Lys 2420 2425 2430 Tyr Thr Gln Leu Cys Gln Tyr Leu Asn Thr Leu Thr Leu Ala Val 2435 2440 2445 Pro Tyr Asn Met Arg Val Ile His Phe Gly Ala Gly Ser Asp Lys 2450 2455 2460 Gly Val Ala Pro Gly Thr Ala Val Leu Arg Gln Trp Leu Pro Thr 2465 2470 2475 Gly Thr Leu Leu Val Asp Ser Asp Leu Asn Asp Phe Val Ser Asp 2480 2485 2490 Ala Asp Ser Thr Leu Ile Gly Asp Cys Ala Thr Val His Thr Ala 2495 2500 2505 Asn Lys Trp Asp Leu Ile Ile Ser Asp Met Tyr Asp Pro Arg Thr 2510 2515 2520 Lys His Val Thr Lys Glu Asn Asp Ser Lys Glu Gly Phe Phe Thr 2525 2530 2535 Tyr Leu Cys Gly Phe Ile Lys Gln Lys Leu Ala Leu Gly Gly Ser 2540 2545 2550 Ile Ala Val Lys Ile Thr Glu His Ser Trp Asn Ala Asp Leu Tyr 2555 2560 2565 Lys Leu Met Gly His Phe Ser Trp Trp Thr Ala Phe Val Thr Asn 2570 2575 2580 Val Asn Ala Ser Ser Ser Glu Ala Phe Leu Ile Gly Ala Asn Tyr 2585 2590 2595 Leu Gly Lys Pro Lys Glu Gln Ile Asp Gly Tyr Thr Met His Ala 2600 2605 2610 Asn Tyr Ile Phe Trp Arg Asn Thr Asn Pro Ile Gln Leu Ser Ser 2615 2620 2625 Tyr Ser Leu Phe Asp Met Ser Lys Phe Pro Leu Lys Leu Arg Gly 2630 2635 2640 Thr Ala Val Met Ser Leu Lys Glu Asn Gln Ile Asn Asp Met Ile 2645 2650 2655 Tyr Ser Leu Leu Glu Lys Gly Arg Leu Ile Ile Arg Glu Asn Asn 2660 2665 2670 Arg Val Val Val Ser Ser Asp Ile Leu Val Asn Asn 2675 2680 2685 <210> 85 <211> 2652 <212> PRT <213> avian infectious bronchitis virus <220> <221> MISC_FEATURE <223> ORF 1B <400> 85 Met Phe Gln Asn Leu Lys Arg Asn Cys Ala Arg Phe Gln Glu Leu Arg 1 5 10 15 Asp Thr Glu Asp Gly Asn Leu Glu Tyr Leu Asp Ser Tyr Phe Val Val 20 25 30 Lys Gln Thr Thr Pro Ser Asn Tyr Glu His Glu Lys Ser Cys Tyr Glu 35 40 45 Asp Leu Lys Ser Glu Val Thr Ala Asp His Asp Phe Phe Val Phe Asn 50 55 60 Lys Asn Ile Tyr Asn Ile Ser Arg Gln Arg Leu Thr Lys Tyr Thr Met 65 70 75 80 Met Asp Phe Cys Tyr Ala Leu Arg His Phe Asp Pro Lys Asp Cys Glu 85 90 95 Val Leu Lys Glu Ile Leu Val Thr Tyr Gly Cys Ile Glu Asp Tyr His 100 105 110 Pro Lys Trp Phe Glu Glu Asn Lys Asp Trp Tyr Asp Pro Ile Glu Asn 115 120 125 Ser Lys Tyr Tyr Val Met Leu Ala Lys Met Gly Pro Ile Val Arg Arg 130 135 140 Ala Leu Leu Asn Ala Ile Glu Phe Gly Asn Leu Met Val Glu Lys Gly 145 150 155 160 Tyr Val Gly Val Ile Thr Leu Asp Asn Gln Asp Leu Asn Gly Lys Phe 165 170 175 Tyr Asp Phe Gly Asp Phe Gln Lys Thr Ala Pro Gly Ala Gly Val Pro 180 185 190 Val Phe Asp Thr Tyr Tyr Ser Tyr Met Met Pro Ile Ile Ala Met Thr 195 200 205 Asp Ala Leu Ala Pro Glu Arg Tyr Phe Glu Tyr Asp Val His Lys Gly 210 215 220 Tyr Lys Ser Tyr Asp Leu Leu Lys Tyr Asp Tyr Thr Glu Glu Lys Gln 225 230 235 240 Glu Leu Phe Gln Lys Tyr Phe Lys Tyr Trp Asp Gln Glu Tyr His Pro 245 250 255 Asn Cys Arg Asp Cys Ser Asp Asp Arg Cys Leu Ile His Cys Ala Asn 260 265 270 Phe Asn Ile Leu Phe Ser Thr Leu Ile Pro Gln Thr Ser Phe Gly Asn 275 280 285 Leu Cys Arg Lys Val Phe Val Asp Gly Val Pro Phe Ile Ala Thr Cys 290 295 300 Gly Tyr His Ser Lys Glu Leu Gly Val Ile Met Asn Gln Asp Asn Thr 305 310 315 320 Met Ser Phe Ser Lys Met Gly Leu Ser Gln Leu Met Gln Phe Val Gly 325 330 335 Asp Pro Ala Leu Leu Val Gly Thr Ser Asn Asn Leu Val Asp Leu Arg 340 345 350 Thr Ser Cys Phe Ser Val Cys Ala Leu Thr Ser Gly Ile Thr His Gln 355 360 365 Thr Val Lys Pro Gly His Phe Asn Lys Asp Phe Tyr Asp Phe Ala Glu 370 375 380 Lys Ala Gly Met Phe Lys Glu Gly Ser Ser Ile Pro Leu Lys His Phe 385 390 395 400 Phe Tyr Pro Gln Thr Gly Asn Ala Ala Ile Asn Asp Tyr Asp Tyr Tyr 405 410 415 Arg Tyr Asn Arg Pro Thr Met Phe Asp Ile Cys Gln Leu Leu Phe Cys 420 425 430 Leu Glu Val Thr Ser Lys Tyr Phe Glu Cys Tyr Glu Gly Gly Cys Ile 435 440 445 Pro Ala Ser Gln Val Val Val Asn Asn Leu Asp Lys Ser Ala Gly Tyr 450 455 460 Pro Phe Asn Lys Phe Gly Lys Ala Arg Leu Tyr Tyr Glu Met Ser Leu 465 470 475 480 Glu Glu Gln Asp Gln Leu Phe Glu Ile Thr Lys Lys Asn Val Leu Pro 485 490 495 Thr Ile Thr Gln Met Asn Leu Lys Tyr Ala Ile Ser Ala Lys Asn Arg 500 505 510 Ala Arg Thr Val Ala Gly Val Ser Ile Leu Ser Thr Met Thr Asn Arg 515 520 525 Gln Phe His Gln Lys Ile Leu Lys Ser Ile Val Asn Thr Arg Asn Ala 530 535 540 Ser Val Val Ile Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asp Asn Met 545 550 555 560 Leu Arg Asn Leu Ile Gln Gly Val Glu Asp Pro Ile Leu Met Gly Trp 565 570 575 Asp Tyr Pro Lys Cys Asp Arg Ala Met Pro Asn Leu Leu Arg Ile Ala 580 585 590 Ala Ser Leu Val Leu Ala Arg Lys His Thr Asn Cys Cys Ser Trp Ser 595 600 605 Glu Arg Ile Tyr Arg Leu Tyr Asn Glu Cys Ala Gln Val Leu Ser Glu 610 615 620 Thr Val Leu Ala Thr Gly Gly Ile Tyr Val Lys Pro Gly Gly Thr Ser 625 630 635 640 Ser Gly Asp Ala Thr Thr Ala Tyr Ala Asn Ser Val Phe Asn Ile Ile 645 650 655 Gln Ala Thr Ser Ala Asn Val Ala Arg Leu Leu Ser Val Ile Thr Arg 660 665 670 Asp Ile Val Tyr Asp Asn Ile Lys Ser Leu Gln Tyr Glu Leu Tyr Gln 675 680 685 Gln Val Tyr Arg Arg Val Asn Phe Asp Pro Ala Phe Val Glu Lys Phe 690 695 700 Tyr Ser Tyr Leu Cys Lys Asn Phe Ser Leu Met Ile Leu Ser Asp Asp 705 710 715 720 Gly Val Val Cys Tyr Asn Asn Thr Leu Ala Lys Gln Gly Leu Val Ala 725 730 735 Asp Ile Ser Gly Phe Arg Glu Val Leu Tyr Tyr Gln Asn Asn Val Phe 740 745 750 Met Ala Asp Ser Lys Cys Trp Val Glu Pro Asp Leu Glu Lys Gly Pro 755 760 765 His Glu Phe Cys Ser Gln His Thr Met Leu Val Glu Val Asp Gly Glu 770 775 780 Pro Lys Tyr Leu Pro Tyr Pro Asp Pro Ser Arg Ile Leu Gly Ala Cys 785 790 795 800 Val Phe Val Asp Asp Val Asp Lys Thr Glu Pro Val Ala Val Met Glu 805 810 815 Arg Tyr Ile Ala Leu Ala Ile Asp Ala Tyr Pro Leu Val His His Glu 820 825 830 Asn Glu Glu Tyr Lys Lys Val Phe Phe Val Leu Leu Ala Tyr Ile Arg 835 840 845 Lys Leu Tyr Gln Glu Leu Ser Gln Asn Met Leu Met Asp Tyr Ser Phe 850 855 860 Val Met Asp Ile Asp Lys Gly Ser Lys Phe Trp Glu Gln Glu Phe Tyr 865 870 875 880 Glu Asn Met Tyr Arg Ala Pro Thr Thr Leu Gln Ser Cys Gly Val Cys 885 890 895 Val Val Cys Asn Ser Gln Thr Ile Leu Arg Cys Gly Asn Cys Ile Arg 900 905 910 Lys Pro Phe Leu Cys Cys Lys Cys Cys Tyr Asp His Val Met His Thr 915 920 925 Asp His Lys Asn Val Leu Ser Ile Asn Pro Tyr Ile Cys Ser Gln Leu 930 935 940 Gly Cys Gly Glu Ala Asp Val Thr Lys Leu Tyr Leu Gly Gly Met Ser 945 950 955 960 Tyr Phe Cys Gly Asn His Lys Pro Lys Leu Ser Ile Pro Leu Val Ser 965 970 975 Asn Gly Thr Val Phe Gly Ile Tyr Arg Ala Asn Cys Ala Gly Ser Glu 980 985 990 Asn Val Asp Asp Phe Asn Gln Leu Ala Thr Thr Asn Trp Ser Ile Val 995 1000 1005 Glu Pro Tyr Ile Leu Ala Asn Arg Cys Ser Asp Ser Leu Arg Arg 1010 1015 1020 Phe Ala Ala Glu Thr Val Lys Ala Thr Glu Glu Leu His Lys Gln 1025 1030 1035 Gln Phe Ala Ser Ala Glu Val Arg Glu Val Phe Ser Asp Arg Glu 1040 1045 1050 Leu Ile Leu Ser Trp Glu Pro Gly Lys Thr Arg Pro Pro Leu Asn 1055 1060 1065 Arg Asn Tyr Val Phe Thr Gly Tyr His Phe Thr Arg Thr Ser Lys 1070 1075 1080 Val Gln Leu Gly Asp Phe Thr Phe Glu Lys Gly Glu Gly Lys Asp 1085 1090 1095 Val Val Tyr Tyr Lys Ala Thr Ser Thr Ala Lys Leu Ser Val Gly 1100 1105 1110 Asp Ile Phe Val Leu Thr Ser His Asn Val Val Ser Leu Val Ala 1115 1120 1125 Pro Thr Leu Cys Pro Gln Gln Thr Phe Ser Arg Phe Val Asn Leu 1130 1135 1140 Arg Pro Asn Val Met Val Pro Glu Cys Phe Val Asn Asn Ile Pro 1145 1150 1155 Leu Tyr His Leu Val Gly Lys Gln Lys Arg Thr Thr Val Gln Gly 1160 1165 1170 Pro Pro Gly Ser Gly Lys Ser His Phe Ala Ile Gly Leu Ala Val 1175 1180 1185 Tyr Phe Ser Ser Ala Arg Val Val Phe Thr Ala Cys Ser His Ala 1190 1195 1200 Ala Val Asp Ala Leu Cys Glu Lys Ala Phe Lys Phe Leu Lys Val 1205 1210 1215 Asp Asp Cys Thr Arg Ile Val Pro Gln Arg Thr Thr Val Asp Cys 1220 1225 1230 Phe Ser Lys Phe Lys Ala Asn Asp Thr Gly Lys Lys Tyr Ile Phe 1235 1240 1245 Ser Thr Ile Asn Ala Leu Pro Glu Val Ser Cys Asp Ile Leu Leu 1250 1255 1260 Val Asp Glu Val Ser Met Leu Thr Asn Tyr Glu Leu Ser Phe Ile 1265 1270 1275 Asn Gly Lys Ile Asn Tyr Gln Tyr Val Val Tyr Val Gly Asp Pro 1280 1285 1290 Ala Gln Leu Pro Ala Pro Arg Thr Leu Leu Asn Gly Ser Leu Ser 1295 1300 1305 Pro Lys Asp Tyr Asn Val Val Thr Asn Leu Met Val Cys Val Lys 1310 1315 1320 Pro Asp Ile Phe Leu Ala Lys Cys Tyr Arg Cys Pro Lys Glu Ile 1325 1330 1335 Val Asp Thr Val Ser Thr Leu Val Tyr Asp Gly Lys Phe Ile Ala 1340 1345 1350 Asn Asn Pro Glu Ser Arg Glu Cys Phe Lys Val Ile Val Asn Asn 1355 1360 1365 Gly Asn Ser Asp Val Gly His Glu Ser Gly Ser Ala Tyr Asn Thr 1370 1375 1380 Thr Gln Leu Glu Phe Val Lys Asp Phe Val Cys Arg Asn Lys Gln 1385 1390 1395 Trp Arg Glu Ala Ile Phe Ile Ser Pro Tyr Asn Ala Met Asn Gln 1400 1405 1410 Arg Ala Tyr Arg Met Leu Gly Leu Asn Val Gln Thr Val Asp Ser 1415 1420 1425 Ser Gln Gly Ser Glu Tyr Asp Tyr Val Ile Phe Cys Val Thr Ala 1430 1435 1440 Asp Ser Gln His Ala Leu Asn Ile Asn Arg Phe Asn Val Ala Leu 1445 1450 1455 Thr Arg Ala Lys Arg Gly Ile Leu Val Val Met Arg Gln Arg Asp 1460 1465 1470 Glu Leu Tyr Ser Ala Leu Lys Phe Thr Glu Leu Asp Ser Glu Thr 1475 1480 1485 Ser Leu Gln Gly Thr Gly Leu Phe Lys Ile Cys Asn Lys Glu Phe 1490 1495 1500 Ser Gly Val His Pro Ala Tyr Ala Val Thr Thr Lys Ala Leu Ala 1505 1510 1515 Ala Thr Tyr Lys Val Asn Asp Glu Leu Ala Ala Leu Val Asn Val 1520 1525 1530 Glu Ala Gly Ser Glu Ile Thr Tyr Lys His Leu Ile Ser Leu Leu 1535 1540 1545 Gly Phe Lys Met Ser Val Asn Val Glu Gly Cys His Asn Met Phe 1550 1555 1560 Ile Thr Arg Asp Glu Ala Ile Arg Asn Val Arg Gly Trp Val Gly 1565 1570 1575 Phe Asp Val Glu Ala Thr His Ala Cys Gly Thr Asn Ile Gly Thr 1580 1585 1590 Asn Leu Pro Phe Gln Val Gly Phe Ser Thr Gly Ala Asp Phe Val 1595 1600 1605 Val Thr Pro Glu Gly Leu Val Asp Thr Ser Ile Gly Asn Asn Phe 1610 1615 1620 Glu Pro Val Asn Ser Lys Ala Pro Pro Gly Glu Gln Phe Asn His 1625 1630 1635 Leu Arg Val Leu Phe Lys Ser Ala Lys Pro Trp His Val Ile Arg 1640 1645 1650 Pro Arg Ile Val Gln Met Leu Ala Asp Asn Leu Cys Asn Val Ser 1655 1660 1665 Asp Cys Val Val Phe Val Thr Trp Cys His Gly Leu Glu Leu Thr 1670 1675 1680 Thr Leu Arg Tyr Phe Val Lys Ile Gly Lys Glu Gln Val Cys Ser 1685 1690 1695 Cys Gly Ser Arg Ala Thr Thr Phe Asn Ser His Thr Gln Ala Tyr 1700 1705 1710 Ala Cys Trp Lys His Cys Leu Gly Phe Asp Phe Val Tyr Asn Pro 1715 1720 1725 Leu Leu Val Asp Ile Gln Gln Trp Gly Tyr Ser Gly Asn Leu Gln 1730 1735 1740 Phe Asn His Asp Leu His Cys Asn Val His Gly His Ala His Val 1745 1750 1755 Ala Ser Val Asp Ala Ile Met Thr Arg Cys Leu Ala Ile Asn Asn 1760 1765 1770 Ala Phe Cys Gln Asp Val Asn Trp Asp Leu Thr Tyr Pro His Ile 1775 1780 1785 Ala Asn Glu Asp Glu Val Asn Ser Ser Cys Arg Tyr Leu Gln Arg 1790 1795 1800 Met Tyr Leu Asn Ala Cys Val Asp Ala Leu Lys Val Asn Val Val 1805 1810 1815 Tyr Asp Ile Gly Asn Pro Lys Gly Ile Lys Cys Val Arg Arg Gly 1820 1825 1830 Asp Val Asn Phe Arg Phe Tyr Asp Lys Asn Pro Ile Val Arg Asn 1835 1840 1845 Val Lys Gln Phe Glu Tyr Asp Tyr Asn Gln His Lys Asp Lys Phe 1850 1855 1860 Ala Asp Gly Leu Cys Met Phe Trp Asn Cys Asn Val Asp Cys Tyr 1865 1870 1875 Pro Asp Asn Ser Leu Val Cys Arg Tyr Asp Thr Arg Asn Leu Ser 1880 1885 1890 Val Phe Asn Leu Pro Gly Cys Asn Gly Gly Ser Leu Tyr Val Asn 1895 1900 1905 Lys His Ala Phe Tyr Thr Pro Lys Phe Asp Arg Ile Ser Phe Arg 1910 1915 1920 Asn Leu Lys Ala Met Pro Phe Phe Phe Tyr Asp Ser Ser Pro Cys 1925 1930 1935 Glu Thr Ile Gln Val Asp Gly Val Ala Gln Asp Leu Val Ser Leu 1940 1945 1950 Ala Thr Lys Asp Cys Ile Thr Lys Cys Asn Ile Gly Gly Ala Val 1955 1960 1965 Cys Lys Lys His Ala Gln Met Tyr Ala Glu Phe Val Thr Ser Tyr 1970 1975 1980 Asn Ala Ala Val Thr Ala Gly Phe Thr Phe Trp Val Thr Asn Lys 1985 1990 1995 Leu Asn Pro Tyr Asn Leu Trp Lys Ser Phe Ser Ala Leu Gln Ser 2000 2005 2010 Ile Asp Asn Ile Ala Tyr Asn Met Tyr Lys Gly Gly His Tyr Asp 2015 2020 2025 Ala Ile Ala Gly Glu Met Pro Thr Val Ile Thr Gly Asp Lys Val 2030 2035 2040 Phe Val Ile Asp Gln Gly Val Glu Lys Ala Val Phe Val Asn Gln 2045 2050 2055 Thr Thr Leu Pro Thr Ser Val Ala Phe Glu Leu Tyr Ala Lys Arg 2060 2065 2070 Asn Ile Arg Thr Leu Pro Asn Asn Arg Ile Leu Lys Gly Leu Gly 2075 2080 2085 Val Asp Val Thr Asn Gly Phe Val Ile Trp Asp Tyr Ala Asn Gln 2090 2095 2100 Thr Pro Leu Tyr Arg Asn Thr Val Lys Val Cys Ala Tyr Thr Asp 2105 2110 2115 Ile Glu Pro Asn Gly Leu Val Val Leu Tyr Asp Asp Arg Tyr Gly 2120 2125 2130 Asp Tyr Gln Ser Phe Leu Ala Ala Asp Asn Ala Val Leu Val Ser 2135 2140 2145 Thr Gln Cys Tyr Lys Arg Tyr Ser Tyr Val Glu Ile Pro Ser Asn 2150 2155 2160 Leu Leu Val Gln Asn Gly Met Pro Leu Lys Asp Gly Ala Asn Leu 2165 2170 2175 Tyr Val Tyr Lys Arg Val Asn Gly Ala Phe Val Thr Leu Pro Asn 2180 2185 2190 Thr Ile Asn Thr Gln Gly Arg Ser Tyr Glu Thr Phe Glu Pro Arg 2195 2200 2205 Ser Asp Ile Glu Arg Asp Phe Leu Ala Met Ser Glu Glu Ser Phe 2210 2215 2220 Val Glu Arg Tyr Gly Lys Asp Leu Gly Leu Gln His Ile Leu Tyr 2225 2230 2235 Gly Glu Val Asp Lys Pro Gln Leu Gly Gly Leu His Thr Val Ile 2240 2245 2250 Gly Met Tyr Arg Leu Leu Arg Ala Asn Lys Leu Asn Ala Lys Ser 2255 2260 2265 Val Thr Asn Ser Asp Ser Asp Val Met Gln Asn Tyr Phe Val Leu 2270 2275 2280 Ser Asp Asn Gly Ser Tyr Lys Gln Val Cys Thr Val Val Asp Leu 2285 2290 2295 Leu Leu Asp Asp Phe Leu Glu Leu Leu Arg Asn Ile Leu Lys Glu 2300 2305 2310 Tyr Gly Thr Asn Lys Ser Lys Val Val Thr Val Ser Ile Asp Tyr 2315 2320 2325 His Ser Ile Asn Phe Met Thr Trp Phe Glu Asp Gly Ser Ile Lys 2330 2335 2340 Thr Cys Tyr Pro Gln Leu Gln Ser Ala Trp Thr Cys Gly Tyr Asn 2345 2350 2355 Met Pro Glu Leu Tyr Lys Val Gln Asn Cys Val Met Glu Pro Cys 2360 2365 2370 Asn Ile Pro Asn Tyr Gly Val Gly Ile Thr Leu Pro Ser Gly Ile 2375 2380 2385 Leu Met Asn Val Ala Lys Tyr Thr Gln Leu Cys Gln Tyr Leu Ser 2390 2395 2400 Lys Thr Thr Ile Cys Val Pro His Asn Met Arg Val Met His Phe 2405 2410 2415 Gly Ala Gly Ser Asp Lys Gly Val Ala Pro Gly Ser Thr Val Leu 2420 2425 2430 Lys Gln Trp Leu Pro Glu Gly Thr Leu Leu Val Asp Asn Asp Ile 2435 2440 2445 Val Asp Tyr Val Ser Asp Ala His Val Ser Val Leu Ser Asp Cys 2450 2455 2460 Asn Lys Tyr Asn Thr Glu His Lys Phe Asp Leu Val Ile Ser Asp 2465 2470 2475 Met Tyr Thr Asp Asn Asp Ser Lys Arg Lys His Glu Gly Val Ile 2480 2485 2490 Ala Asn Asn Gly Asn Asp Asp Val Phe Ile Tyr Leu Ser Ser Phe 2495 2500 2505 Leu Arg Asn Asn Leu Ala Leu Gly Gly Ser Phe Ala Val Lys Val 2510 2515 2520 Thr Glu Thr Ser Trp His Glu Val Leu Tyr Asp Ile Ala Gln Asp 2525 2530 2535 Cys Ala Trp Trp Thr Met Phe Cys Thr Ala Val Asn Ala Ser Ser 2540 2545 2550 Ser Glu Ala Phe Leu Ile Gly Val Asn Tyr Leu Gly Ala Ser Glu 2555 2560 2565 Lys Val Lys Val Ser Gly Lys Thr Leu His Ala Asn Tyr Ile Phe 2570 2575 2580 Trp Arg Asn Cys Asn Tyr Leu Gln Thr Ser Ala Tyr Ser Ile Phe 2585 2590 2595 Asp Val Ala Lys Phe Asp Leu Arg Leu Lys Ala Thr Pro Val Val 2600 2605 2610 Asn Leu Lys Thr Glu Gln Lys Thr Asp Leu Val Phe Asn Leu Ile 2615 2620 2625 Lys Cys Gly Lys Leu Leu Val Arg Asp Val Gly Asn Thr Ser Phe 2630 2635 2640 Thr Ser Asp Ser Phe Val Cys Thr Met 2645 2650 <210> 86 <211> 2685 <212> PRT <213> bovine coronavirus <220> <221> MISC_FEATURE <223> ORF 1B <400> 86 Phe Phe Lys Arg Val Arg Gly Thr Ser Val Asp Ala Arg Leu Val Pro 1 5 10 15 Cys Ala Ser Gly Leu Ser Thr Asp Val Gln Leu Arg Ala Phe Asp Ile 20 25 30 Cys Asn Ala Ser Val Ala Gly Ile Gly Leu His Leu Lys Val Asn Cys 35 40 45 Cys Arg Phe Gln Arg Val Asp Glu Asn Gly Asp Lys Leu Asp Gln Phe 50 55 60 Phe Val Val Lys Arg Thr Asp Leu Thr Ile Tyr Asn Arg Glu Met Glu 65 70 75 80 Cys Tyr Glu Arg Val Lys Asp Cys Lys Phe Val Ala Glu His Asp Phe 85 90 95 Phe Thr Phe Asp Val Glu Gly Ser Arg Val Pro His Ile Val Arg Lys 100 105 110 Asp Leu Thr Lys Tyr Thr Met Leu Asp Leu Cys Tyr Ala Leu Arg His 115 120 125 Phe Asp Arg Asn Asp Cys Met Leu Leu Cys Asp Ile Leu Ser Ile Tyr 130 135 140 Ala Gly Cys Glu Gln Ser Tyr Phe Thr Lys Lys Asp Trp Tyr Asp Phe 145 150 155 160 Val Glu Asn Pro Asp Ile Ile Asn Val Tyr Lys Lys Leu Gly Pro Ile 165 170 175 Phe Asn Arg Ala Leu Val Ser Ala Thr Glu Phe Ala Asp Lys Leu Val 180 185 190 Glu Val Gly Leu Val Gly Ile Leu Thr Leu Asp Asn Gln Asp Leu Asn 195 200 205 Gly Lys Trp Tyr Asp Phe Gly Asp Tyr Val Ile Ala Ala Pro Gly Cys 210 215 220 Gly Val Ala Ile Ala Asp Ser Tyr Tyr Ser Tyr Met Met Pro Met Leu 225 230 235 240 Thr Met Cys His Ala Leu Asp Cys Glu Leu Tyr Val Asn Asn Ala Tyr 245 250 255 Arg Leu Phe Asp Leu Val Gln Tyr Asp Phe Thr Asp Tyr Lys Leu Glu 260 265 270 Leu Phe Asn Lys Tyr Phe Lys His Trp Ser Met Pro Tyr His Pro Asn 275 280 285 Thr Val Asp Cys Gln Asp Asp Arg Cys Ile Ile His Cys Ala Asn Phe 290 295 300 Asn Ile Leu Phe Ser Met Val Leu Pro Asn Thr Cys Phe Gly Pro Leu 305 310 315 320 Val Arg Gln Ile Phe Val Asp Gly Val Pro Phe Val Val Ser Ile Gly 325 330 335 Tyr His Tyr Lys Glu Leu Gly Ile Val Met Asn Met Asp Val Asp Thr 340 345 350 His Arg Tyr Arg Leu Ser Leu Lys Asp Leu Leu Leu Tyr Ala Ala Asp 355 360 365 Pro Ala Leu His Val Ala Ser Ala Ser Ala Leu Tyr Asp Leu Arg Thr 370 375 380 Cys Cys Phe Ser Val Ala Ala Ile Thr Ser Gly Val Lys Phe Gln Thr 385 390 395 400 Val Lys Pro Gly Asn Phe Asn Gln Asp Phe Tyr Asp Phe Ile Leu Ser 405 410 415 Lys Gly Leu Leu Lys Glu Gly Ser Ser Val Asp Leu Lys His Phe Phe 420 425 430 Phe Thr Gln Asp Gly Asn Ala Ala Ile Thr Asp Tyr Asn Tyr Tyr Lys 435 440 445 Tyr Asn Leu Pro Thr Met Val Asp Ile Lys Gln Leu Leu Phe Val Leu 450 455 460 Glu Val Val Tyr Lys Tyr Phe Glu Ile Tyr Asp Gly Gly Cys Ile Pro 465 470 475 480 Ala Ala Gln Val Ile Val Asn Asn Tyr Asp Lys Ser Ala Gly Tyr Pro 485 490 495 Phe Asn Lys Phe Gly Lys Ala Arg Leu Tyr Tyr Glu Ala Leu Ser Phe 500 505 510 Glu Glu Gln Asp Glu Ile Tyr Ala Tyr Thr Lys Arg Asn Val Leu Pro 515 520 525 Thr Leu Thr Gln Met Asn Leu Lys Tyr Ala Ile Ser Ala Lys Asn Arg 530 535 540 Ala Arg Thr Val Ala Gly Val Ser Ile Leu Ser Thr Met Thr Gly Arg 545 550 555 560 Met Phe His Gln Lys Cys Leu Lys Ser Ile Ala Ala Thr Arg Gly Val 565 570 575 Pro Val Val Ile Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asp Asp Met 580 585 590 Leu Arg Arg Leu Ile Lys Asp Val Asp Asn Pro Val Leu Met Gly Trp 595 600 605 Asp Tyr Pro Lys Cys Asp Arg Ala Met Pro Asn Ile Leu Arg Ile Val 610 615 620 Ser Ser Leu Val Leu Ala Arg Lys His Glu Ala Cys Cys Ser Gln Ser 625 630 635 640 Asp Arg Phe Tyr Arg Leu Ala Asn Glu Cys Ala Gln Val Leu Ser Glu 645 650 655 Ile Val Met Cys Gly Gly Cys Tyr Tyr Val Lys Pro Gly Gly Thr Ser 660 665 670 Ser Gly Asp Ala Thr Thr Ala Phe Ala Asn Ser Val Phe Asn Ile Cys 675 680 685 Gln Ala Val Ser Ala Asn Val Cys Ala Leu Met Ser Cys Asn Gly Asn 690 695 700 Lys Ile Glu Asp Leu Ser Ile Arg Ala Leu Gln Lys Arg Leu Tyr Ser 705 710 715 720 His Val Tyr Arg Ser Asp Met Val Asp Ser Thr Phe Val Thr Glu Tyr 725 730 735 Tyr Glu Phe Leu Asn Lys His Phe Ser Met Met Ile Leu Ser Asp Asp 740 745 750 Gly Val Val Cys Tyr Asn Ser Asp Tyr Ala Ser Lys Gly Tyr Ile Ala 755 760 765 Asn Ile Ser Ala Phe Gln Gln Val Leu Tyr Tyr Gln Asn Asn Val Phe 770 775 780 Met Ser Glu Ser Lys Cys Trp Val Glu Asn Asp Ile Asn Asn Gly Pro 785 790 795 800 His Glu Phe Cys Ser Gln His Thr Met Leu Val Lys Met Asp Gly Asp 805 810 815 Asp Val Tyr Leu Pro Tyr Pro Val Pro Ser Arg Ile Leu Gly Ala Gly 820 825 830 Cys Phe Val Asp Asp Leu Leu Lys Thr Asp Ser Val Leu Leu Ile Glu 835 840 845 Arg Phe Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu Val Tyr His Glu 850 855 860 Asn Glu Glu Tyr Gln Lys Val Phe Arg Val Tyr Leu Glu Tyr Ile Lys 865 870 875 880 Lys Leu Tyr Asn Glu Leu Gly Asn Gln Ile Leu Asp Ser Tyr Ser Val 885 890 895 Ile Leu Ser Thr Cys Asp Gly Gln Lys Phe Thr Asp Glu Ser Phe Tyr 900 905 910 Lys Asn Met Tyr Leu Arg Ser Ala Val Met Gln Ser Val Gly Ala Cys 915 920 925 Val Val Cys Ser Ser Gln Thr Ser Leu Arg Cys Gly Ser Cys Ile Arg 930 935 940 Lys Pro Leu Leu Cys Cys Lys Cys Cys Tyr Asp His Val Met Ala Thr 945 950 955 960 Asp His Lys Tyr Val Leu Ser Val Ser Pro Tyr Val Cys Asn Ala Pro 965 970 975 Gly Cys Asp Val Asn Asp Val Thr Lys Leu Tyr Leu Gly Gly Met Ser 980 985 990 Tyr Tyr Cys Glu Asp His Lys Pro Gln Tyr Ser Phe Lys Leu Val Met 995 1000 1005 Asn Gly Met Val Phe Gly Leu Tyr Lys Gln Ser Cys Thr Gly Ser 1010 1015 1020 Pro Tyr Ile Asp Asp Phe Asn Arg Ile Ala Ser Cys Lys Trp Thr 1025 1030 1035 Asp Val Asp Asp Tyr Ile Leu Ala Asn Glu Cys Thr Glu Arg Leu 1040 1045 1050 Lys Leu Phe Ala Ala Glu Thr Gln Lys Ala Thr Glu Glu Ala Phe 1055 1060 1065 Lys Gln Ser Tyr Ala Ser Ala Thr Ile Gln Glu Ile Val Ser Glu 1070 1075 1080 Arg Glu Leu Ile Leu Ser Trp Glu Ile Gly Lys Val Lys Pro Pro 1085 1090 1095 Leu Asn Lys Asn Tyr Val Phe Thr Gly Tyr His Phe Thr Lys Asn 1100 1105 1110 Gly Lys Thr Val Leu Gly Glu Tyr Val Phe Asp Lys Ser Glu Leu 1115 1120 1125 Thr Asn Gly Val Tyr Tyr Arg Ala Thr Thr Thr Tyr Lys Leu Ser 1130 1135 1140 Val Gly Asp Val Phe Val Leu Thr Ser His Ser Val Ala Asn Leu 1145 1150 1155 Ser Ala Pro Thr Leu Val Pro Gln Glu Asn Tyr Ser Ser Ile Arg 1160 1165 1170 Phe Ala Ser Val Tyr Ser Val Leu Glu Thr Phe Gln Asn Asn Val 1175 1180 1185 Val Asn Tyr Gln His Ile Gly Met Lys Arg Tyr Cys Thr Val Gln 1190 1195 1200 Gly Pro Pro Gly Thr Gly Lys Ser His Leu Ala Ile Gly Leu Ala 1205 1210 1215 Val Tyr Tyr Cys Thr Ala Arg Val Val Tyr Thr Ala Ala Ser His 1220 1225 1230 Ala Ala Val Asp Ala Leu Cys Glu Lys Ala Tyr Lys Phe Leu Asn 1235 1240 1245 Ile Asn Asp Cys Thr Arg Ile Val Pro Ala Lys Val Arg Val Glu 1250 1255 1260 Cys Tyr Asp Lys Phe Lys Ile Asn Asp Thr Thr Arg Lys Tyr Val 1265 1270 1275 Phe Thr Thr Ile Asn Ala Leu Pro Glu Met Val Thr Asp Ile Val 1280 1285 1290 Val Val Asp Glu Val Ser Met Leu Thr Asn Tyr Glu Leu Ser Val 1295 1300 1305 Ile Asn Ala Arg Ile Arg Ala Lys His Tyr Val Tyr Ile Gly Asp 1310 1315 1320 Pro Ala Gln Leu Pro Ala Pro Arg Val Leu Leu Ser Lys Gly Thr 1325 1330 1335 Leu Glu Pro Lys Tyr Phe Asn Thr Val Thr Lys Leu Met Cys Cys 1340 1345 1350 Leu Gly Pro Asp Ile Phe Leu Gly Thr Cys Tyr Arg Cys Pro Lys 1355 1360 1365 Glu Ile Val Asp Thr Val Ser Ala Leu Val Tyr Glu Asn Lys Leu 1370 1375 1380 Lys Ala Lys Asn Glu Ser Ser Ser Leu Cys Phe Lys Val Tyr Tyr 1385 1390 1395 Lys Gly Val Thr Thr His Glu Ser Ser Ser Ala Val Asn Met Gln 1400 1405 1410 Gln Ile Tyr Leu Ile Asn Lys Phe Leu Lys Ala Asn Pro Leu Trp 1415 1420 1425 His Lys Ala Val Phe Ile Ser Pro Tyr Asn Ser Gln Asn Phe Ala 1430 1435 1440 Ala Lys Arg Val Leu Gly Leu Gln Thr Gln Thr Val Asp Ser Ala 1445 1450 1455 Gln Gly Ser Glu Tyr Asp Tyr Val Ile Tyr Ser Gln Thr Ala Glu 1460 1465 1470 Thr Ala His Ser Val Asn Val Asn Arg Phe Asn Val Ala Ile Thr 1475 1480 1485 Arg Ala Lys Lys Gly Ile Leu Cys Val Met Ser Asn Met Gln Leu 1490 1495 1500 Phe Glu Ala Leu Gln Phe Thr Thr Leu Thr Val Asp Lys Val Pro 1505 1510 1515 Gln Ala Val Glu Thr Arg Val Gln Cys Ser Thr Asn Leu Phe Lys 1520 1525 1530 Asp Cys Ser Lys Ser Tyr Ser Gly Tyr His Pro Ala His Ala Pro 1535 1540 1545 Ser Phe Leu Ala Val Asp Asp Lys Tyr Lys Ala Thr Gly Asp Leu 1550 1555 1560 Ala Val Cys Leu Gly Ile Gly Asp Ser Ala Val Thr Tyr Ser Arg 1565 1570 1575 Leu Ile Ser Leu Met Gly Phe Lys Leu Asp Val Thr Leu Asp Gly 1580 1585 1590 Tyr Cys Lys Leu Phe Ile Thr Lys Glu Glu Ala Val Lys Arg Val 1595 1600 1605 Arg Ala Trp Val Gly Phe Asp Ala Glu Gly Ala His Ala Thr Arg 1610 1615 1620 Asp Ser Ile Gly Thr Asn Phe Pro Leu Gln Leu Gly Phe Ser Thr 1625 1630 1635 Gly Ile Asp Phe Val Val Glu Ala Thr Gly Leu Phe Ala Asp Arg 1640 1645 1650 Asp Gly Tyr Ser Phe Lys Lys Ala Val Ala Lys Ala Pro Pro Gly 1655 1660 1665 Glu Gln Phe Lys His Leu Ile Pro Leu Met Thr Arg Gly Gln Arg 1670 1675 1680 Trp Asp Val Val Arg Pro Arg Ile Val Gln Met Phe Ala Asp His 1685 1690 1695 Leu Ile Asp Leu Ser Asp Cys Val Val Leu Val Thr Trp Ala Ala 1700 1705 1710 Asn Phe Glu Leu Thr Cys Leu Arg Tyr Phe Ala Lys Val Gly Arg 1715 1720 1725 Glu Ile Ser Cys Asn Val Ser Thr Lys Arg Ala Thr Ala Tyr Asn 1730 1735 1740 Ser Arg Thr Gly Tyr Tyr Gly Cys Trp Arg His Ser Val Thr Cys 1745 1750 1755 Asp Tyr Leu Tyr Asn Pro Leu Ile Val Asp Ile Gln Gln Trp Gly 1760 1765 1770 Tyr Ile Gly Ser Leu Ser Ser Asn His Asp Leu Tyr Cys Ser Val 1775 1780 1785 His Lys Gly Ala His Val Ala Ser Ser Asp Ala Ile Met Thr Arg 1790 1795 1800 Cys Leu Ala Val Tyr Asp Cys Phe Cys Asn Asn Ile Asn Trp Asn 1805 1810 1815 Val Glu Tyr Pro Ile Ile Ser Asn Glu Leu Ser Ile Asn Thr Ser 1820 1825 1830 Cys Arg Val Leu Gln Arg Val Met Leu Lys Ala Ala Met Leu Cys 1835 1840 1845 Asn Arg Tyr Thr Leu Cys Tyr Asp Ile Gly Asn Pro Lys Ala Ile 1850 1855 1860 Ala Cys Val Lys Asp Phe Asp Phe Lys Phe Tyr Asp Ala Gln Pro 1865 1870 1875 Ile Val Lys Ser Val Lys Thr Leu Leu Tyr Phe Phe Glu Ala His 1880 1885 1890 Lys Asp Ser Phe Lys Asp Gly Leu Cys Met Phe Trp Asn Cys Asn 1895 1900 1905 Val Asp Lys Tyr Pro Pro Asn Ala Val Val Cys Arg Phe Asp Thr 1910 1915 1920 Arg Val Leu Asn Asn Leu Asn Leu Pro Gly Cys Asn Gly Gly Ser 1925 1930 1935 Leu Tyr Val Asn Lys His Ala Phe His Thr Lys Pro Phe Ser Arg 1940 1945 1950 Ala Ala Phe Glu His Leu Lys Pro Met Pro Phe Phe Tyr Tyr Ser 1955 1960 1965 Asp Thr Pro Cys Val Tyr Met Asp Gly Met Asp Ala Lys Gln Val 1970 1975 1980 Asp Tyr Val Pro Leu Lys Ser Ala Thr Cys Ile Thr Arg Cys Asn 1985 1990 1995 Leu Gly Gly Ala Val Cys Leu Lys His Ala Glu Glu Tyr Arg Glu 2000 2005 2010 Tyr Leu Glu Ser Tyr Asn Thr Ala Thr Thr Ala Gly Phe Thr Phe 2015 2020 2025 Trp Val Tyr Lys Thr Phe Asp Phe Tyr Asn Leu Trp Asn Thr Phe 2030 2035 2040 Thr Lys Leu Gln Ser Leu Glu Asn Val Val Tyr Asn Leu Val Lys 2045 2050 2055 Thr Gly His Tyr Thr Gly Gln Ala Gly Glu Met Pro Cys Ala Ile 2060 2065 2070 Ile Asn Asp Lys Val Val Ala Lys Ile Asp Lys Glu Asp Val Val 2075 2080 2085 Ile Phe Ile Asn Asn Thr Thr Tyr Pro Thr Asn Val Ala Val Glu 2090 2095 2100 Leu Phe Ala Lys Arg Ser Ile Arg His His Pro Glu Leu Lys Leu 2105 2110 2115 Phe Arg Asn Leu Asn Ile Asp Val Cys Trp Lys His Val Ile Trp 2120 2125 2130 Asp Tyr Ala Arg Glu Ser Ile Phe Cys Ser Asn Thr Tyr Gly Val 2135 2140 2145 Cys Met Tyr Thr Asp Leu Lys Leu Ile Asp Lys Leu Asn Val Leu 2150 2155 2160 Phe Asp Gly Arg Asp Asn Gly Ala Leu Glu Ala Phe Lys Arg Ser 2165 2170 2175 Asn Asn Gly Val Tyr Ile Ser Thr Thr Lys Val Lys Ser Leu Ser 2180 2185 2190 Met Ile Arg Gly Pro Pro Arg Ala Glu Leu Asn Gly Val Val Val 2195 2200 2205 Asp Lys Val Gly Asp Thr Asp Cys Val Phe Tyr Phe Ala Val Arg 2210 2215 2220 Lys Glu Gly Gln Asp Val Ile Phe Ser Gln Phe Asp Ser Leu Arg 2225 2230 2235 Val Ser Ser Asn Gln Ser Pro Gln Gly Asn Leu Gly Ser Asn Glu 2240 2245 2250 Pro Gly Asn Val Gly Gly Asn Asp Ala Leu Ala Thr Ser Thr Ile 2255 2260 2265 Phe Thr Gln Ser Arg Val Ile Ser Ser Phe Thr Cys Arg Thr Asp 2270 2275 2280 Met Glu Lys Asp Phe Ile Ala Leu Asp Gln Asp Val Phe Ile Gln 2285 2290 2295 Lys Tyr Gly Leu Glu Asp Tyr Ala Phe Glu His Ile Val Tyr Gly 2300 2305 2310 Asn Phe Asn Gln Lys Ile Ile Gly Gly Leu His Leu Leu Ile Gly 2315 2320 2325 Leu Tyr Arg Arg Gln Gln Thr Ser Asn Leu Val Ile Gln Glu Phe 2330 2335 2340 Val Ser Tyr Asp Ser Ser Ile His Ser Tyr Phe Ile Thr Asp Glu 2345 2350 2355 Lys Ser Gly Gly Ser Lys Ser Val Cys Thr Val Ile Asp Ile Leu 2360 2365 2370 Leu Asp Asp Phe Val Ala Leu Val Lys Ser Leu Asn Leu Asn Cys 2375 2380 2385 Val Ser Lys Val Val Asn Val Asn Val Asp Phe Lys Asp Phe Gln 2390 2395 2400 Phe Met Leu Trp Cys Asn Asp Glu Lys Val Met Thr Phe Tyr Pro 2405 2410 2415 Arg Leu Gln Ala Ala Ser Asp Trp Lys Pro Gly Tyr Ser Met Pro 2420 2425 2430 Val Leu Tyr Lys Tyr Leu Asn Ser Pro Met Glu Arg Val Ser Leu 2435 2440 2445 Trp Asn Tyr Gly Lys Pro Val Thr Leu Pro Thr Gly Cys Met Met 2450 2455 2460 Asn Val Ala Lys Tyr Thr Gln Leu Cys Gln Tyr Leu Asn Thr Thr 2465 2470 2475 Thr Leu Ala Val Pro Val Asn Thr Arg Val Leu His Leu Gly Ala 2480 2485 2490 Gly Ser Glu Lys Gly Val Ala Pro Gly Ser Ala Val Leu Arg Gln 2495 2500 2505 Trp Leu Pro Ala Gly Thr Ile Leu Arg Gln Trp Leu Pro Ala Gly 2510 2515 2520 Thr Ile Leu Val His Asn Asp Leu Tyr Pro Phe Val Ser Asp Ser 2525 2530 2535 Val Ala Thr Tyr Phe Gly Asp Cys Ile Thr Leu Pro Phe Asp Cys 2540 2545 2550 Gln Trp Asp Leu Ile Ile Ser Asp Met Tyr Asp Leu Leu Leu Asp 2555 2560 2565 Ile Gly Val His Val Val Arg Cys Ser Tyr Ile His Cys His Met 2570 2575 2580 Ile Arg Asp Lys Leu Ala Leu Gly Gly Ser Val Ala Ile Lys Ile 2585 2590 2595 Thr Glu Phe Ser Trp Asn Ala Glu Leu Tyr Lys Leu Met Gly Tyr 2600 2605 2610 Phe Ala Phe Trp Thr Val Phe Cys Thr Asn Ala Asn Ala Ser Ser 2615 2620 2625 Ser Glu Gly Phe Leu Ile Gly Ile Asn Tyr Leu Gly Lys Pro Lys 2630 2635 2640 Val Glu Ile Asp Gly Asn Val Met His Ala Ile Ile Cys Phe Gly 2645 2650 2655 Glu Ile Pro Gln Phe Gly Thr Gly Val Leu Ile Ala Cys Leu Ile 2660 2665 2670 Trp Leu Asn Ser Arg Leu Ser Trp Leu Val Met Pro 2675 2680 2685 <210> 87 <211> 2678 <212> PRT <213> EMCR Coronavirus <220> <221> MISC_FEATURE <223> ORF 1B <220> <221> MISC_FEATURE <222> (844)..(844) <223> Unknown amino acid <400> 87 Arg Ala Arg Gly Ser Ser Ala Ala Arg Leu Glu Pro Cys Asn Gly Thr 1 5 10 15 Asp Ile Asp Lys Cys Val Arg Ala Phe Asp Ile Tyr Asn Lys Asn Val 20 25 30 Ser Phe Leu Gly Lys Cys Leu Lys Met Asn Cys Val Arg Phe Lys Asn 35 40 45 Ala Asp Leu Lys Asp Gly Tyr Phe Val Ile Lys Arg Cys Thr Lys Ser 50 55 60 Val Met Glu His Glu Gln Ser Met Tyr Asn Leu Leu Asn Phe Ser Gly 65 70 75 80 Ala Leu Ala Glu His Asp Phe Phe Thr Trp Lys Asp Gly Arg Val Ile 85 90 95 Tyr Gly Asn Val Ser Arg His Asn Leu Thr Lys Tyr Thr Met Met Asp 100 105 110 Leu Val Tyr Ala Met Arg Asn Phe Asp Glu Gln Asn Cys Asp Val Leu 115 120 125 Lys Glu Val Leu Val Leu Thr Gly Cys Cys Asp Asn Ser Tyr Phe Asp 130 135 140 Ser Lys Gly Trp Tyr Asp Pro Val Glu Asn Glu Asp Ile His Arg Val 145 150 155 160 Tyr Ala Ser Leu Gly Lys Ile Val Ala Arg Ala Met Leu Lys Cys Val 165 170 175 Ala Leu Cys Asp Ala Met Val Ala Lys Gly Val Val Gly Val Leu Thr 180 185 190 Leu Asp Asn Gln Asp Leu Asn Gly Asn Phe Tyr Asp Phe Gly Asp Phe 195 200 205 Val Val Ser Leu Pro Asn Met Gly Val Pro Cys Cys Thr Ser Tyr Tyr 210 215 220 Ser Tyr Met Met Pro Ile Met Gly Leu Thr Asn Cys Leu Ala Ser Glu 225 230 235 240 Cys Phe Val Lys Ser Asp Ile Phe Gly Ser Asp Phe Lys Thr Phe Asp 245 250 255 Leu Leu Lys Tyr Asp Phe Thr Glu His Lys Glu Asn Leu Phe Asn Lys 260 265 270 Tyr Phe Lys His Trp Ser Phe Asp Tyr His Pro Asn Cys Ser Asp Cys 275 280 285 Tyr Asp Asp Met Cys Val Ile His Cys Ala Asn Phe Asn Thr Leu Phe 290 295 300 Ala Thr Thr Ile Pro Gly Thr Ala Phe Gly Pro Leu Cys Arg Lys Val 305 310 315 320 Phe Ile Asp Gly Val Pro Leu Val Thr Thr Ala Gly Tyr His Phe Lys 325 330 335 Gln Leu Gly Leu Val Trp Asn Lys Asp Val Asn Thr His Ser Val Arg 340 345 350 Leu Thr Ile Thr Glu Leu Leu Gln Phe Val Thr Asp Pro Ser Leu Ile 355 360 365 Ile Ala Ser Ser Pro Ala Leu Val Asp Gln Arg Thr Ile Cys Phe Ser 370 375 380 Val Ala Ala Leu Ser Thr Gly Leu Thr Asn Gln Val Val Lys Pro Gly 385 390 395 400 His Phe Asn Glu Glu Phe Tyr Asn Phe Leu Arg Leu Arg Gly Phe Phe 405 410 415 Asp Glu Gly Ser Glu Leu Thr Leu Lys His Phe Phe Phe Ala Gln Asn 420 425 430 Gly Asp Ala Ala Val Lys Asp Phe Asp Phe Tyr Arg Tyr Asn Lys Pro 435 440 445 Thr Ile Leu Asp Ile Cys Gln Ala Arg Val Thr Tyr Lys Ile Val Ser 450 455 460 Arg Tyr Phe Asp Ile Tyr Glu Gly Gly Cys Ile Lys Ala Cys Glu Val 465 470 475 480 Val Val Thr Asn Leu Asn Lys Ser Ala Gly Trp Pro Leu Asn Lys Phe 485 490 495 Gly Lys Ala Ser Leu Tyr Tyr Glu Ser Ile Ser Tyr Glu Glu Gln Asp 500 505 510 Ala Leu Phe Ala Leu Thr Lys Arg Asn Val Leu Pro Thr Met Thr Gln 515 520 525 Leu Asn Leu Lys Tyr Ala Ile Ser Gly Lys Glu Arg Ala Arg Thr Val 530 535 540 Gly Gly Val Ser Leu Leu Ser Thr Met Thr Thr Arg Gln Tyr His Gln 545 550 555 560 Lys His Leu Lys Ser Ile Val Asn Thr Arg Asn Ala Thr Val Val Ile 565 570 575 Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asn Asn Met Leu Arg Thr Leu 580 585 590 Ile Asp Gly Val Glu Asn Pro Met Leu Met Gly Trp Asp Tyr Pro Lys 595 600 605 Cys Asp Arg Ala Leu Pro Asn Met Ile Arg Met Ile Ser Ala Met Val 610 615 620 Leu Gly Ser Lys His Val Asn Cys Cys Thr Val Thr Asp Arg Phe Tyr 625 630 635 640 Arg Leu Gly Asn Glu Leu Ala Gln Val Leu Thr Glu Val Val Tyr Ser 645 650 655 Asn Gly Gly Phe Tyr Phe Lys Pro Gly Gly Thr Thr Ser Gly Asp Ala 660 665 670 Ser Thr Ala Tyr Ala Asn Ser Ile Phe Asn Ile Phe Gln Ala Val Ser 675 680 685 Ser Asn Ile Asn Arg Leu Leu Ser Val Pro Ser Asp Ser Cys Asn Asn 690 695 700 Val Asn Val Arg Asp Leu Gln Arg Arg Leu Tyr Asp Asn Cys Tyr Arg 705 710 715 720 Leu Thr Ser Val Glu Glu Ser Phe Ile Asp Asp Tyr Tyr Gly Tyr Leu 725 730 735 Arg Lys His Phe Ser Met Met Ile Leu Ser Asp Asp Gly Val Val Cys 740 745 750 Tyr Asn Lys Asp Tyr Ala Glu Leu Gly Tyr Ile Ala Asp Ile Ser Ala 755 760 765 Phe Lys Ala Thr Leu Tyr Tyr Gln Asn Asn Val Phe Met Ser Thr Ser 770 775 780 Lys Cys Trp Val Glu Glu Asp Leu Thr Lys Gly Pro His Glu Phe Cys 785 790 795 800 Ser Gln His Thr Met Gln Ile Val Asp Lys Asp Gly Thr Tyr Tyr Leu 805 810 815 Pro Tyr Pro Asp Pro Ser Arg Ile Leu Ser Ala Gly Val Phe Val Asp 820 825 830 Asp Val Val Lys Thr Asp Ala Val Val Leu Leu Xaa Arg Tyr Val Ser 835 840 845 Leu Ala Ile Asp Ala Tyr Pro Leu Ser Lys His Pro Asn Ser Glu Tyr 850 855 860 Arg Lys Val Phe Tyr Val Leu Leu Asp Trp Val Lys His Leu Asn Lys 865 870 875 880 Asn Leu Asn Glu Gly Val Leu Glu Ser Phe Ser Val Thr Leu Leu Asp 885 890 895 Asn Gln Glu Asp Lys Phe Trp Cys Glu Asp Phe Tyr Ala Ser Met Tyr 900 905 910 Glu Asn Ser Thr Ile Leu Gln Ala Ala Gly Leu Cys Val Val Cys Gly 915 920 925 Ser Gln Thr Val Leu Arg Cys Gly Asp Cys Leu Arg Lys Pro Met Leu 930 935 940 Cys Thr Lys Cys Ala Tyr Asp His Val Phe Gly Thr Asp His Lys Phe 945 950 955 960 Ile Leu Ala Ile Thr Pro Tyr Val Cys Asn Ala Ser Gly Cys Gly Val 965 970 975 Ser Asp Val Lys Lys Leu Tyr Leu Gly Gly Leu Asn Tyr Tyr Cys Thr 980 985 990 Asn His Lys Pro Gln Leu Ser Phe Pro Leu Cys Ser Ala Gly Asn Ile 995 1000 1005 Phe Gly Leu Tyr Lys Asn Ser Ala Thr Gly Ser Leu Asp Val Glu 1010 1015 1020 Val Phe Asn Arg Leu Ala Thr Ser Asp Trp Thr Asp Val Arg Asp 1025 1030 1035 Tyr Lys Leu Ala Asn Asp Val Lys Asp Thr Leu Arg Leu Phe Ala 1040 1045 1050 Ala Glu Thr Ile Lys Ala Lys Glu Glu Ser Val Lys Ser Ser Tyr 1055 1060 1065 Ala Phe Ala Thr Leu Lys Glu Val Val Gly Pro Lys Glu Leu Leu 1070 1075 1080 Leu Ser Trp Glu Ser Gly Lys Val Lys Pro Pro Leu Asn Arg Asn 1085 1090 1095 Ser Val Phe Thr Cys Phe Gln Ile Ser Lys Asp Ser Lys Phe Gln 1100 1105 1110 Ile Gly Glu Phe Ile Phe Glu Lys Val Glu Tyr Gly Ser Asp Thr 1115 1120 1125 Val Thr Tyr Lys Ser Thr Val Thr Thr Lys Leu Val Pro Gly Met 1130 1135 1140 Ile Phe Val Leu Thr Ser His Asn Val Gln Pro Leu Arg Ala Pro 1145 1150 1155 Thr Ile Ala Asn Gln Glu Lys Tyr Ser Ser Ile Tyr Lys Leu His 1160 1165 1170 Pro Ala Phe Asn Val Ser Asp Ala Tyr Ala Asn Leu Val Pro Tyr 1175 1180 1185 Tyr Gln Leu Ile Gly Lys Gln Lys Ile Thr Thr Ile Gln Gly Pro 1190 1195 1200 Pro Gly Ser Gly Lys Ser His Cys Ser Ile Gly Leu Gly Leu Tyr 1205 1210 1215 Tyr Pro Gly Ala Arg Ile Val Phe Val Ala Cys Ala His Ala Ala 1220 1225 1230 Val Asp Ser Leu Cys Ala Lys Ala Met Thr Val Tyr Ser Ile Asp 1235 1240 1245 Lys Cys Thr Arg Ile Ile Pro Ala Arg Ala Arg Val Glu Cys Tyr 1250 1255 1260 Ser Gly Phe Lys Pro Asn Asn Thr Ser Ala Gln Tyr Ile Phe Ser 1265 1270 1275 Thr Val Asn Ala Leu Pro Glu Cys Asn Ala Asp Ile Val Val Val 1280 1285 1290 Asp Glu Val Ser Met Cys Thr Asn Tyr Asp Leu Ser Val Ile Asn 1295 1300 1305 Gln Arg Leu Ser Tyr Lys His Ile Val Tyr Val Gly Asp Pro Gln 1310 1315 1320 Gln Leu Pro Ala Pro Arg Val Met Ile Thr Lys Gly Val Met Glu 1325 1330 1335 Pro Val Asp Tyr Asn Val Val Thr Gln Arg Met Cys Ala Ile Gly 1340 1345 1350 Pro Asp Val Phe Leu His Lys Cys Tyr Arg Cys Pro Ala Glu Ile 1355 1360 1365 Val Asn Thr Val Ser Glu Leu Val Tyr Glu Asn Lys Phe Val Pro 1370 1375 1380 Val Lys Pro Ala Ser Lys Gln Cys Phe Lys Ile Phe Phe Lys Gly 1385 1390 1395 Asn Val Gln Val Asp Asn Gly Ser Ser Ile Asn Arg Lys Gln Leu 1400 1405 1410 Glu Ile Val Lys Leu Phe Leu Val Lys Asn Pro Ser Trp Ser Lys 1415 1420 1425 Ala Val Phe Ile Ser Pro Tyr Asn Ser Gln Asn Tyr Val Ala Ser 1430 1435 1440 Arg Phe Leu Gly Leu Gln Ile Gln Thr Val Asp Ser Ser Gln Gly 1445 1450 1455 Ser Glu Tyr Asp Tyr Val Ile Tyr Ala Gln Thr Ser Asp Thr Ala 1460 1465 1470 His Ala Cys Asn Val Asn Arg Phe Asn Val Ala Ile Thr Arg Ala 1475 1480 1485 Lys Lys Gly Ile Phe Cys Val Met Cys Asp Lys Thr Leu Phe Asp 1490 1495 1500 Ser Leu Lys Phe Phe Glu Ile Lys His Ala Asp Leu His Ser Ser 1505 1510 1515 Gln Val Cys Gly Leu Phe Lys Asn Cys Thr Arg Thr Pro Leu Asn 1520 1525 1530 Leu Pro Pro Thr His Ala His Thr Phe Leu Ser Leu Ser Asp Gln 1535 1540 1545 Phe Lys Thr Thr Gly Asp Leu Ala Val Gln Ile Gly Ser Asn Asn 1550 1555 1560 Val Cys Thr Tyr Glu His Val Ile Ser Phe Met Gly Phe Arg Phe 1565 1570 1575 Asp Ile Ser Ile Pro Gly Ser His Ser Leu Phe Cys Thr Arg Asp 1580 1585 1590 Phe Ala Ile Arg Asn Val Arg Gly Trp Leu Gly Met Asp Val Glu 1595 1600 1605 Ser Ala His Val Cys Gly Asp Asn Ile Gly Thr Asn Val Pro Leu 1610 1615 1620 Gln Val Gly Phe Ser Asn Gly Val Asn Phe Val Val Gln Thr Glu 1625 1630 1635 Gly Cys Val Ser Thr Asn Phe Gly Asp Val Ile Lys Pro Val Cys 1640 1645 1650 Ala Lys Ser Pro Pro Gly Glu Gln Phe Arg His Leu Val Pro Phe 1655 1660 1665 Leu Arg Lys Gly Gln Pro Trp Leu Ile Val Arg Arg Arg Ile Val 1670 1675 1680 Gln Met Ile Ser Asp Tyr Leu Ser Asn Leu Ser Asp Ile Leu Val 1685 1690 1695 Phe Val Leu Trp Ala Gly Ser Leu Glu Leu Thr Thr Met Arg Tyr 1700 1705 1710 Phe Val Lys Ile Gly Pro Ile Lys Tyr Cys Tyr Cys Gly Asn Ser 1715 1720 1725 Ala Thr Cys Tyr Asn Ser Val Ser Asn Glu Tyr Cys Cys Phe Lys 1730 1735 1740 His Ala Leu Gly Cys Asp Tyr Val Tyr Asn Pro Tyr Ala Phe Asp 1745 1750 1755 Ile Gln Gln Trp Gly Tyr Val Gly Ser Leu Ser Gln Asn His His 1760 1765 1770 Thr Phe Cys Asn Ile His Arg Asn Glu His Asp Ala Ser Gly Asp 1775 1780 1785 Ala Val Met Thr Arg Cys Leu Ala Val His Asp Cys Phe Val Lys 1790 1795 1800 Asn Val Asp Trp Thr Val Thr Tyr Pro Phe Ile Ala Asn Glu Lys 1805 1810 1815 Phe Ile Asn Gly Cys Gly Arg Asn Val Gln Gly His Val Val Arg 1820 1825 1830 Ala Ala Leu Lys Leu Tyr Lys Pro Ser Val Ile His Asp Ile Gly 1835 1840 1845 Asn Pro Lys Gly Val Arg Cys Ala Val Thr Asp Ala Lys Trp Tyr 1850 1855 1860 Cys Tyr Asp Lys Gln Pro Val Asn Ser Asn Val Lys Leu Leu Asp 1865 1870 1875 Tyr Asp Tyr Ala Thr His Gly Gln Leu Asp Gly Leu Cys Leu Phe 1880 1885 1890 Trp Asn Cys Asn Val Asp Met Tyr Pro Glu Phe Ser Ile Val Cys 1895 1900 1905 Arg Phe Asp Thr Arg Thr Arg Ser Val Phe Asn Leu Glu Gly Val 1910 1915 1920 Asn Gly Gly Ser Leu Tyr Val Asn Lys His Ala Phe His Thr Pro 1925 1930 1935 Ala Tyr Asp Lys Arg Ala Phe Val Lys Leu Lys Pro Met Pro Phe 1940 1945 1950 Phe Tyr Phe Asp Asp Ser Asp Cys Asp Val Val Gln Glu Gln Val 1955 1960 1965 Asn Tyr Val Pro Leu Arg Ala Ser Ser Cys Val Thr Arg Cys Asn 1970 1975 1980 Ile Gly Gly Ala Val Cys Ser Lys His Ala Asn Leu Tyr Gln Lys 1985 1990 1995 Tyr Val Glu Ala Tyr Asn Thr Phe Thr Gln Ala Gly Phe Asn Ile 2000 2005 2010 Trp Val Pro His Ser Phe Asp Val Tyr Asn Leu Trp Gln Ile Phe 2015 2020 2025 Ile Glu Thr Asn Leu Gln Ser Leu Glu Asn Ile Ala Phe Asn Val 2030 2035 2040 Val Lys Lys Gly Cys Phe Thr Gly Val Asp Gly Glu Leu Pro Val 2045 2050 2055 Ala Val Val Asn Asp Lys Val Phe Val Arg Tyr Gly Asp Val Asp 2060 2065 2070 Asn Leu Val Phe Thr Asn Lys Thr Thr Leu Pro Thr Asn Val Ala 2075 2080 2085 Phe Glu Leu Phe Ala Lys Arg Lys Met Gly Leu Thr Pro Pro Leu 2090 2095 2100 Ser Ile Leu Lys Asn Leu Gly Val Val Ala Thr Tyr Lys Phe Val 2105 2110 2115 Leu Trp Asp Tyr Glu Ala Glu Arg Pro Phe Thr Ser Tyr Thr Lys 2120 2125 2130 Ser Val Cys Lys Tyr Thr Asp Phe Asn Glu Asp Val Cys Val Cys 2135 2140 2145 Phe Asp Asn Ser Ile Gln Gly Ser Tyr Glu Arg Phe Thr Leu Thr 2150 2155 2160 Thr Asn Ala Val Leu Phe Ser Thr Val Val Ile Lys Asn Leu Thr 2165 2170 2175 Pro Ile Lys Leu Asn Phe Gly Met Leu Asn Gly Met Pro Val Ser 2180 2185 2190 Ser Ile Lys Ser Asp Lys Gly Val Glu Lys Leu Val Asn Trp Tyr 2195 2200 2205 Thr Tyr Val Arg Lys Asn Gly Gln Phe Gln Asp His Tyr Asp Gly 2210 2215 2220 Phe Tyr Thr Gln Gly Arg Asn Leu Ser Asp Phe Thr Pro Arg Ser 2225 2230 2235 Asp Met Glu Tyr Asp Phe Leu Asn Met Asp Met Gly Val Phe Ile 2240 2245 2250 Asn Lys Tyr Gly Leu Glu Asp Phe Asn Phe Glu His Val Val Tyr 2255 2260 2265 Gly Asp Val Ser Lys Thr Thr Leu Gly Gly Leu His Leu Leu Ile 2270 2275 2280 Ser Gln Phe Arg Leu Ser Lys Met Gly Val Leu Lys Ala Asp Asp 2285 2290 2295 Phe Val Thr Ala Ser Asp Thr Thr Leu Arg Cys Cys Thr Val Thr 2300 2305 2310 Tyr Leu Asn Glu Leu Ser Ser Lys Val Val Cys Thr Tyr Met Asp 2315 2320 2325 Leu Leu Leu Asp Asp Phe Val Thr Ile Leu Lys Ser Leu Asp Leu 2330 2335 2340 Gly Val Ile Ser Lys Val His Glu Val Ile Ile Asp Asn Lys Pro 2345 2350 2355 Tyr Arg Trp Met Leu Trp Cys Lys Asp Asn His Leu Ser Thr Phe 2360 2365 2370 Tyr Pro Gln Leu Gln Ser Ala Glu Trp Lys Cys Gly Tyr Ala Met 2375 2380 2385 Pro Gln Ile Tyr Lys Leu Gln Arg Met Cys Leu Glu Pro Cys Asn 2390 2395 2400 Leu Tyr Asn Tyr Gly Ala Gly Ile Lys Leu Pro Ser Gly Ile Met 2405 2410 2415 Leu Asn Val Val Lys Tyr Thr Gln Leu Cys Gln Tyr Leu Asn Ser 2420 2425 2430 Thr Thr Met Cys Val Pro His Asn Met Arg Val Leu His Tyr Gly 2435 2440 2445 Ala Gly Ser Asp Lys Gly Val Ala Pro Gly Thr Thr Val Leu Lys 2450 2455 2460 Arg Trp Leu Pro Pro Asp Ala Ile Ile Ile Asp Asn Asp Ile Asn 2465 2470 2475 Asp Tyr Val Ser Asp Ala Asp Phe Ser Ile Thr Gly Asp Cys Ala 2480 2485 2490 Thr Val Tyr Leu Glu Asp Lys Phe Asp Leu Leu Ile Ser Asp Met 2495 2500 2505 Tyr Asp Gly Arg Ile Lys Phe Cys Asp Gly Glu Asn Val Ser Lys 2510 2515 2520 Asp Gly Phe Phe Thr Tyr Leu Asn Gly Val Ile Arg Glu Lys Leu 2525 2530 2535 Ala Ile Gly Gly Ser Val Ala Ile Lys Ile Thr Glu Tyr Ser Trp 2540 2545 2550 Asn Lys Tyr Leu Tyr Glu Leu Ile Gln Arg Phe Ala Phe Trp Thr 2555 2560 2565 Leu Phe Cys Thr Ser Val Asn Thr Ser Ser Ser Glu Ala Phe Leu 2570 2575 2580 Ile Gly Ile Asn Tyr Leu Gly Asp Phe Ile Gln Gly Pro Phe Ile 2585 2590 2595 Ala Gly Asn Thr Val His Ala Asn Tyr Ile Phe Trp Arg Asn Ser 2600 2605 2610 Thr Ile Met Ser Leu Ser Tyr Asn Ser Val Leu Asp Leu Ser Lys 2615 2620 2625 Phe Glu Cys Lys His Lys Ala Thr Val Val Val Thr Leu Lys Asp 2630 2635 2640 Ser Asp Val Asn Asp Met Val Leu Ser Leu Ile Lys Ser Gly Arg 2645 2650 2655 Leu Leu Leu Arg Asn Ser Gly Arg Phe Gly Gly Phe Ser Asn His 2660 2665 2670 Leu Val Ser Thr Lys 2675 <210> 88 <211> 2733 <212> PRT <213> murine hepatitis virus <220> <221> MISC_FEATURE <223> ORF 1B <400> 88 Leu Phe Leu Cys Arg His Arg Leu Pro Val Ser Val Lys Arg His Glu 1 5 10 15 Leu Phe Lys Arg Val Arg Gly Thr Ser Val Asn Ala Arg Leu Val Pro 20 25 30 Cys Ala Ser Gly Leu Asp Thr Asp Val Gln Leu Arg Ala Phe Asp Ile 35 40 45 Cys Asn Ala Asn Arg Ala Gly Ile Gly Leu Tyr Tyr Lys Val Asn Cys 50 55 60 Cys Arg Phe Gln Arg Ala Asp Glu Asp Gly Asn Thr Leu Asp Lys Phe 65 70 75 80 Phe Val Ile Lys Arg Thr Asn Leu Glu Val Tyr Asn Lys Glu Lys Glu 85 90 95 Cys Tyr Glu Leu Thr Lys Glu Cys Gly Val Val Ala Glu His Glu Phe 100 105 110 Phe Thr Phe Asp Val Glu Gly Ser Arg Val Pro His Ile Val Arg Lys 115 120 125 Asp Leu Ser Lys Tyr Thr Met Leu Asp Leu Cys Tyr Ala Leu Arg His 130 135 140 Phe Asp Arg Asn Asp Cys Ser Thr Leu Lys Glu Ile Leu Leu Thr Tyr 145 150 155 160 Ala Glu Cys Asp Glu Ser Tyr Phe Gln Lys Lys Asp Trp Tyr Asp Phe 165 170 175 Val Glu Asn Ser Asp Ile Ile Asn Val Tyr Lys Lys Leu Gly Pro Ile 180 185 190 Phe Asn Arg Ala Leu Leu Asn Thr Ala Lys Phe Ala Asp Thr Leu Val 195 200 205 Glu Ala Gly Leu Val Gly Val Leu Thr Leu Asp Asn Gln Asp Leu Tyr 210 215 220 Gly Gln Trp Tyr Asp Phe Gly Asp Phe Val Lys Thr Val Pro Gly Cys 225 230 235 240 Gly Val Ala Val Ala Asp Ser Tyr Tyr Ser Tyr Met Met Pro Met Leu 245 250 255 Thr Met Cys His Ala Leu Asp Ser Glu Leu Phe Ile Asn Gly Thr Tyr 260 265 270 Arg Glu Phe Asp Leu Val Gln Tyr Asp Phe Thr Asp Phe Lys Leu Glu 275 280 285 Leu Phe Asn Lys Tyr Phe Lys Tyr Trp Ser Met Thr Tyr His Pro Asn 290 295 300 Thr Cys Glu Cys Glu Asp Asp Arg Cys Ile Ile His Cys Ala Asn Phe 305 310 315 320 Asn Ile Leu Phe Ser Met Val Leu Pro Lys Thr Cys Phe Gly Pro Leu 325 330 335 Val Arg Gln Ile Phe Val Asp Gly Val Pro Phe Val Val Ser Ile Gly 340 345 350 Tyr His Tyr Lys Glu Leu Gly Val Val Met Asn Met Asp Val Asp Thr 355 360 365 His Arg Tyr Arg Leu Ser Leu Lys Asp Leu Leu Leu Tyr Ala Ala Asp 370 375 380 Pro Ala Leu His Val Ala Ser Ala Ser Ala Leu Leu Asp Leu Arg Thr 385 390 395 400 Cys Cys Phe Ser Val Ala Ala Ile Thr Ser Gly Val Lys Phe Gln Thr 405 410 415 Val Lys Pro Gly Asn Phe Asn Gln Asp Phe Tyr Glu Phe Ile Leu Ser 420 425 430 Lys Gly Leu Leu Lys Glu Gly Ser Ser Val Asp Leu Lys His Phe Phe 435 440 445 Phe Thr Gln Asp Gly Asn Ala Ala Ile Thr Asp Tyr Asn Tyr Tyr Lys 450 455 460 Tyr Asn Leu Pro Thr Met Val Asp Ile Lys Gln Leu Leu Phe Val Leu 465 470 475 480 Glu Val Val Asn Lys Tyr Phe Glu Ile Tyr Asp Gly Gly Cys Ile Pro 485 490 495 Ala Thr Gln Val Ile Val Asn Asn Tyr Asp Lys Ser Ala Gly Tyr Pro 500 505 510 Phe Asn Lys Phe Gly Lys Ala Arg Leu Tyr Tyr Glu Ala Leu Ser Phe 515 520 525 Glu Glu Gln Asp Glu Val Tyr Ala Tyr Thr Lys Arg Asn Val Leu Pro 530 535 540 Thr Leu Thr Gln Met Asn Leu Lys Tyr Ala Ile Ser Ala Lys Asn Arg 545 550 555 560 Ala Arg Thr Val Ala Gly Val Ser Ile Leu Ser Thr Met Thr Gly Arg 565 570 575 Met Phe His Gln Lys Cys Leu Lys Ser Ile Ala Ala Thr Arg Gly Val 580 585 590 Pro Val Val Ile Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asp Asp Met 595 600 605 Leu Arg Arg Leu Ile Lys Asp Val Asp Ser Pro Val Leu Met Gly Trp 610 615 620 Asp Tyr Pro Lys Cys Asp Arg Ala Met Pro Asn Ile Leu Arg Ile Ile 625 630 635 640 Ser Ser Leu Val Leu Ala Arg Lys His Asp Ser Cys Cys Ser His Thr 645 650 655 Asp Arg Phe Tyr Arg Leu Ala Asn Glu Cys Ala Gln Val Leu Ser Glu 660 665 670 Ile Val Met Cys Gly Gly Cys Tyr Tyr Val Lys Pro Gly Gly Thr Ser 675 680 685 Ser Gly Asp Ala Thr Thr Ala Phe Ala Asn Ser Val Phe Asn Ile Cys 690 695 700 Gln Ala Val Ser Ala Asn Val Cys Ser Leu Met Ala Cys Asn Gly His 705 710 715 720 Lys Ile Glu Asp Leu Ser Ile Arg Glu Leu Gln Lys Arg Leu Tyr Ser 725 730 735 Asn Val Tyr Arg Ala Asp His Val Asp Pro Ala Phe Val Asn Glu Tyr 740 745 750 Tyr Glu Phe Leu Asn Lys His Phe Ser Met Met Ile Leu Ser Asp Asp 755 760 765 Gly Val Val Cys Tyr Asn Ser Glu Phe Ala Ser Lys Gly Tyr Ile Ala 770 775 780 Asn Ile Ser Ala Phe Gln Gln Val Leu Tyr Tyr Gln Asn Asn Val Phe 785 790 795 800 Met Ser Glu Ala Lys Cys Trp Val Glu Thr Asp Ile Glu Lys Gly Pro 805 810 815 His Glu Phe Cys Ser Gln His Thr Met Leu Val Lys Met Asp Gly Asp 820 825 830 Glu Val Tyr Leu Pro Tyr Pro Asp Pro Ser Arg Ile Leu Gly Ala Gly 835 840 845 Cys Phe Val Asp Asp Leu Leu Lys Thr Asp Ser Val Leu Leu Ile Glu 850 855 860 Arg Phe Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu Val Tyr His Glu 865 870 875 880 Asn Pro Glu Tyr Gln Asn Val Phe Arg Val Tyr Leu Glu Tyr Ile Lys 885 890 895 Lys Leu Tyr Asn Asp Leu Gly Asn Gln Ile Leu Asp Ser Tyr Ser Val 900 905 910 Ile Leu Ser Thr Cys Asp Gly Gln Lys Phe Thr Asp Glu Thr Phe Tyr 915 920 925 Lys Asn Met Tyr Leu Arg Ser Ala Val Met Gln Ser Val Gly Ala Cys 930 935 940 Val Val Cys Ser Ser Gln Thr Ser Leu Arg Cys Gly Ser Cys Ile Arg 945 950 955 960 Lys Pro Leu Leu Cys Cys Lys Cys Ala Tyr Asp His Val Met Ser Thr 965 970 975 Asp His Lys Tyr Val Leu Ser Val Ser Pro Tyr Val Cys Asn Ser Pro 980 985 990 Gly Cys Asp Val Asn Asp Val Thr Lys Leu Tyr Leu Gly Gly Met Ser 995 1000 1005 Tyr Tyr Cys Glu Asp His Lys Pro Gln Tyr Ser Phe Lys Leu Val 1010 1015 1020 Met Asn Gly Met Val Phe Gly Leu Tyr Lys Gln Ser Cys Thr Gly 1025 1030 1035 Ser Pro Tyr Ile Glu Asp Phe Asn Lys Ile Ala Ser Cys Lys Trp 1040 1045 1050 Thr Glu Val Asp Asp Tyr Val Leu Ala Asn Glu Cys Thr Glu Arg 1055 1060 1065 Leu Lys Leu Phe Ala Ala Glu Thr Gln Lys Ala Thr Glu Glu Ser 1070 1075 1080 Phe Lys Gln Cys Tyr Ala Ser Ala Thr Ile Arg Glu Ile Val Ser 1085 1090 1095 Asp Arg Glu Leu Ile Leu Ser Trp Glu Ile Gly Lys Val Arg Pro 1100 1105 1110 Pro Leu Asn Lys Asn Tyr Val Phe Thr Gly Tyr His Phe Thr Ser 1115 1120 1125 Asn Gly Lys Thr Val Leu Gly Glu Tyr Val Phe Asp Lys Ser Glu 1130 1135 1140 Leu Thr Asn Gly Val Tyr Tyr Arg Ala Thr Thr Thr Tyr Lys Leu 1145 1150 1155 Ser Val Gly Asp Val Phe Ile Leu Thr Ser His Ala Val Ser Ser 1160 1165 1170 Leu Ser Ala Pro Thr Leu Val Pro Gln Glu Asn Tyr Thr Ser Ile 1175 1180 1185 Arg Phe Ala Ser Val Tyr Ser Val Pro Glu Thr Phe Gln Asn Asn 1190 1195 1200 Val Pro Asn Tyr Gln His Ile Gly Met Lys Arg Tyr Cys Thr Val 1205 1210 1215 Gln Gly Pro Pro Gly Thr Gly Lys Ser His Leu Ala Ile Gly Leu 1220 1225 1230 Ala Val Tyr Tyr Cys Thr Ala Arg Val Val Tyr Thr Ala Ala Ser 1235 1240 1245 His Ala Ala Val Asp Ala Leu Cys Glu Lys Ala Tyr Lys Phe Leu 1250 1255 1260 Asn Ile Asn Asp Cys Thr Arg Ile Val Pro Ala Lys Val Arg Val 1265 1270 1275 Asp Cys Tyr Asp Lys Phe Lys Val Asn Asp Thr Thr Arg Lys Tyr 1280 1285 1290 Val Phe Thr Thr Ile Asn Ala Leu Pro Glu Leu Val Thr Asp Ile 1295 1300 1305 Ile Val Val Asp Glu Val Ser Met Leu Thr Asn Tyr Glu Leu Ser 1310 1315 1320 Val Ile Asn Ser Arg Val Arg Ala Lys His Tyr Val Tyr Ile Gly 1325 1330 1335 Asp Pro Ala Gln Leu Pro Ala Pro Arg Val Leu Leu Asn Lys Gly 1340 1345 1350 Thr Leu Glu Pro Arg Tyr Phe Asn Ser Val Thr Lys Leu Met Cys 1355 1360 1365 Cys Leu Gly Pro Asp Ile Phe Leu Gly Thr Cys Tyr Arg Cys Pro 1370 1375 1380 Lys Glu Ile Val Asp Thr Val Ser Ala Leu Val Tyr His Asn Lys 1385 1390 1395 Leu Lys Ala Lys Asn Asp Asn Ser Ser Met Cys Phe Lys Val Tyr 1400 1405 1410 Tyr Lys Gly Gln Thr Thr His Glu Ser Ser Ser Ala Val Asn Met 1415 1420 1425 Gln Gln Ile Tyr Leu Ile Ser Lys Phe Leu Lys Ala Asn Pro Ser 1430 1435 1440 Trp Ser Asn Ala Val Phe Ile Ser Pro Tyr Asn Ser Gln Asn Tyr 1445 1450 1455 Val Ala Lys Arg Val Leu Gly Leu Gln Thr Gln Thr Val Asp Ser 1460 1465 1470 Ala Gln Gly Ser Glu Tyr Asp Phe Val Ile Tyr Ser Gln Thr Ala 1475 1480 1485 Glu Thr Ala His Ser Val Asn Val Asn Arg Phe Asn Val Ala Ile 1490 1495 1500 Thr Arg Ala Lys Lys Gly Ile Leu Cys Val Met Ser Ser Met Gln 1505 1510 1515 Leu Phe Glu Ser Leu Asn Phe Ser Thr Leu Thr Leu Asp Lys Ile 1520 1525 1530 Asn Asn Pro Arg Leu Gln Cys Thr Thr Asn Leu Phe Lys Asp Cys 1535 1540 1545 Ser Arg Ser Tyr Ala Gly Tyr His Pro Ala His Ala Pro Ser Phe 1550 1555 1560 Leu Ala Val Asp Asp Lys Tyr Lys Val Gly Gly Asp Leu Ala Val 1565 1570 1575 Cys Leu Asn Val Ala Asp Ser Ala Val Thr Tyr Ser Arg Leu Ile 1580 1585 1590 Ser Leu Met Gly Phe Lys Leu Asp Leu Thr Leu Asp Gly Tyr Cys 1595 1600 1605 Lys Leu Phe Ile Thr Arg Asp Glu Ala Ile Arg Arg Val Arg Ala 1610 1615 1620 Trp Val Gly Phe Asp Ala Glu Gly Ala His Ala Thr Arg Asp Ser 1625 1630 1635 Ile Gly Thr Asn Phe Pro Leu Gln Leu Gly Phe Ser Thr Gly Ile 1640 1645 1650 Asp Phe Val Val Glu Ala Thr Gly Met Phe Ala Glu Arg Asp Gly 1655 1660 1665 Tyr Val Phe Lys Lys Ala Val Ala Arg Ala Pro Pro Gly Glu Gln 1670 1675 1680 Phe Lys His Leu Val Pro Leu Met Ser Arg Gly Gln Lys Trp Asp 1685 1690 1695 Val Val Arg Ile Arg Ile Val Gln Met Leu Ser Asp His Leu Val 1700 1705 1710 Asp Leu Ala Asp Ser Val Val Leu Val Thr Trp Ala Ala Ser Phe 1715 1720 1725 Glu Leu Thr Cys Leu Arg Tyr Phe Ala Lys Val Gly Lys Glu Val 1730 1735 1740 Val Cys Ser Val Cys Asn Lys Arg Ala Thr Cys Phe Asn Ser Arg 1745 1750 1755 Thr Gly Tyr Tyr Gly Cys Trp Arg His Ser Tyr Ser Cys Asp Tyr 1760 1765 1770 Leu Tyr Asn Pro Leu Ile Val Asp Ile Gln Gln Trp Gly Tyr Thr 1775 1780 1785 Gly Ser Leu Thr Ser Asn His Asp Leu Ile Cys Ser Val His Lys 1790 1795 1800 Gly Ala His Val Ala Ser Ser Asp Ala Ile Met Thr Arg Cys Leu 1805 1810 1815 Ala Val His Asp Cys Phe Cys Lys Ser Val Asn Trp Ser Leu Glu 1820 1825 1830 Tyr Pro Ile Ile Ser Asn Glu Val Ser Val Asn Thr Ser Cys Arg 1835 1840 1845 Leu Leu Gln Arg Val Met Phe Arg Ala Ala Met Leu Cys Asn Arg 1850 1855 1860 Tyr Asp Val Cys Tyr Asp Ile Gly Asn Pro Lys Gly Leu Ala Cys 1865 1870 1875 Val Lys Gly Tyr Asp Phe Lys Phe Tyr Asp Ala Ser Pro Val Val 1880 1885 1890 Lys Ser Val Lys Gln Phe Val Tyr Lys Tyr Glu Ala His Lys Asp 1895 1900 1905 Gln Phe Leu Asp Gly Leu Cys Met Phe Trp Asn Cys Asn Val Asp 1910 1915 1920 Lys Tyr Pro Ala Asn Ala Val Val Cys Arg Phe Asp Thr Arg Val 1925 1930 1935 Leu Asn Lys Leu Asn Leu Pro Gly Cys Asn Gly Gly Ser Leu Tyr 1940 1945 1950 Val Asn Lys His Ala Phe His Thr Ser Pro Phe Thr Arg Ala Ala 1955 1960 1965 Phe Glu Asn Leu Lys Pro Met Pro Phe Phe Tyr Tyr Ser Asp Thr 1970 1975 1980 Pro Cys Val Tyr Met Glu Gly Met Glu Ser Lys Gln Val Asp Tyr 1985 1990 1995 Val Pro Leu Arg Ser Ala Thr Cys Ile Thr Arg Cys Asn Leu Gly 2000 2005 2010 Gly Ala Val Cys Leu Lys His Ala Glu Asp Tyr Arg Glu Tyr Leu 2015 2020 2025 Glu Ser Tyr Asn Thr Ala Thr Thr Ala Gly Phe Thr Phe Trp Val 2030 2035 2040 Tyr Lys Thr Phe Asp Phe Tyr Asn Leu Trp Asn Thr Phe Thr Arg 2045 2050 2055 Leu Gln Ser Leu Glu Asn Val Val Tyr Asn Leu Val Asn Ala Gly 2060 2065 2070 His Phe Asp Gly Arg Ala Gly Glu Leu Pro Cys Ala Val Ile Gly 2075 2080 2085 Glu Lys Val Ile Ala Lys Ile Gln Asn Glu Asp Val Val Val Phe 2090 2095 2100 Lys Asn Asn Thr Pro Phe Pro Thr Asn Val Ala Val Glu Leu Phe 2105 2110 2115 Ala Lys Arg Ser Ile Arg Pro His Pro Glu Leu Lys Leu Phe Arg 2120 2125 2130 Asn Leu Asn Ile Asp Val Cys Trp Ser His Val Leu Trp Asp Tyr 2135 2140 2145 Ala Lys Asp Ser Val Phe Cys Ser Ser Thr Tyr Lys Val Cys Lys 2150 2155 2160 Tyr Thr Asp Leu Gln Cys Ile Glu Ser Leu Asn Val Leu Phe Asp 2165 2170 2175 Gly Arg Asp Asn Gly Ala Leu Glu Ala Phe Lys Lys Cys Arg Asp 2180 2185 2190 Gly Val Tyr Ile Asn Thr Thr Lys Ile Lys Ser Leu Ser Met Ile 2195 2200 2205 Lys Gly Pro Gln Arg Ala Asp Leu Asn Gly Val Val Val Glu Lys 2210 2215 2220 Val Gly Asp Ser Asp Val Glu Phe Trp Phe Ala Met Arg Arg Asp 2225 2230 2235 Gly Asp Asp Val Ile Phe Ser Arg Thr Gly Ser Leu Glu Pro Ser 2240 2245 2250 His Tyr Arg Ser Pro Gln Gly Asn Pro Gly Gly Asn Arg Val Gly 2255 2260 2265 Asp Leu Ser Gly Asn Glu Ala Leu Ala Arg Gly Thr Ile Phe Thr 2270 2275 2280 Gln Ser Arg Phe Leu Ser Ser Phe Ala Pro Arg Ser Glu Met Glu 2285 2290 2295 Lys Asp Phe Met Asp Leu Asp Glu Asp Val Phe Ile Ala Lys Tyr 2300 2305 2310 Ser Leu Gln Asp Tyr Ala Phe Glu His Val Val Tyr Gly Ser Phe 2315 2320 2325 Asn Gln Lys Ile Ile Gly Gly Leu His Leu Leu Ile Gly Leu Ala 2330 2335 2340 Arg Arg Gln Gln Lys Ser Asn Leu Val Ile Gln Glu Phe Val Pro 2345 2350 2355 Tyr Asp Ser Ser Ile His Ser Tyr Phe Ile Thr Asp Glu Asn Ser 2360 2365 2370 Gly Ser Ser Lys Ser Val Cys Thr Val Ile Asp Leu Leu Leu Asp 2375 2380 2385 Asp Phe Val Asp Ile Val Lys Ser Leu Asn Leu Asn Cys Val Ser 2390 2395 2400 Lys Val Val Asn Val Asn Val Asp Phe Lys Asp Phe Gln Phe Met 2405 2410 2415 Leu Trp Cys Asn Glu Glu Lys Val Met Thr Phe Tyr Pro Arg Leu 2420 2425 2430 Gln Ala Ala Ala Asp Trp Lys Pro Gly Tyr Val Met Pro Val Leu 2435 2440 2445 Tyr Lys Tyr Leu Glu Ser Pro Leu Glu Arg Val Asn Leu Trp Asn 2450 2455 2460 Tyr Gly Lys Pro Ile Thr Leu Pro Thr Gly Cys Leu Met Asn Val 2465 2470 2475 Ala Lys Tyr Thr Gln Leu Cys Gln Tyr Leu Asn Thr Thr Thr Leu 2480 2485 2490 Ala Val Pro Ala Asn Met Arg Val Leu His Leu Gly Ala Gly Ser 2495 2500 2505 Asp Lys Asp Val Ala Pro Gly Ser Ala Val Leu Arg Gln Trp Leu 2510 2515 2520 Pro Ala Gly Ser Ile Leu Val Asp Asn Asp Ile Asn Pro Phe Val 2525 2530 2535 Ser Asp Ser Val Ala Ser Tyr Tyr Gly Asn Cys Ile Thr Leu Pro 2540 2545 2550 Ile Ala Cys Gln Trp Asp Leu Ile Ile Ser Asp Met Tyr Asp Pro 2555 2560 2565 Leu Thr Lys Asn Ile Gly Glu Tyr Asn Val Ser Lys Asp Gly Phe 2570 2575 2580 Phe Thr Tyr Leu Cys His Leu Ile Arg Asp Lys Leu Ala Leu Gly 2585 2590 2595 Gly Ser Val Ala Ile Lys Ile Thr Glu Phe Ser Trp Asn Ala Glu 2600 2605 2610 Leu Tyr Ser Leu Met Gly Lys Phe Ala Phe Trp Thr Ile Phe Cys 2615 2620 2625 Thr Asn Val Asn Ala Ser Ser Ser Glu Gly Phe Leu Ile Gly Ile 2630 2635 2640 Asn Trp Leu Asn Arg Thr Arg Thr Glu Ile Asp Gly Lys Thr Met 2645 2650 2655 His Ala Asn Tyr Leu Phe Trp Arg Asn Ser Thr Met Trp Asn Gly 2660 2665 2670 Gly Ala Tyr Ser Leu Phe Asp Met Ser Lys Phe Pro Leu Lys Val 2675 2680 2685 Ala Gly Thr Ala Val Val Ser Leu Lys Pro Asp Gln Ile Asn Asp 2690 2695 2700 Leu Val Leu Ser Leu Ile Glu Lys Gly Lys Leu Leu Val Arg Asp 2705 2710 2715 Thr Arg Lys Glu Val Phe Val Gly Asp Ser Leu Val Asn Val Lys 2720 2725 2730 <210> 89 <211> 2721 <212> PRT <213> human coronavirus OC43 <220> <221> MISC_FEATURE <223> ORF 1B <400> 89 Phe Phe Lys Arg Val Arg Gly Thr Ser Val Asp Ala Arg Leu Val Pro 1 5 10 15 Cys Ala Ser Gly Leu Ser Thr Asp Val Gln Leu Arg Ala Phe Asp Ile 20 25 30 Tyr Asn Ala Ser Val Ala Gly Ile Gly Leu His Leu Lys Val Asn Cys 35 40 45 Cys Arg Phe Gln Arg Val Asp Glu Asn Gly Asp Lys Leu Asp Gln Phe 50 55 60 Phe Val Val Lys Arg Thr Asp Leu Thr Ile Tyr Asn Arg Glu Met Lys 65 70 75 80 Cys Tyr Glu Arg Val Lys Asp Cys Lys Phe Val Ala Glu His Asp Phe 85 90 95 Phe Thr Phe Asp Val Glu Gly Ser Arg Val Pro His Ile Val Arg Lys 100 105 110 Asp Leu Thr Lys Tyr Thr Met Leu Asp Leu Cys Tyr Ala Leu Arg His 115 120 125 Phe Asp Arg Asn Asp Cys Met Leu Leu Cys Asp Ile Leu Ser Ile Tyr 130 135 140 Ala Gly Cys Glu Gln Ser Tyr Phe Thr Lys Lys Asp Trp Tyr Asp Phe 145 150 155 160 Val Glu Asn Pro Asp Ile Ile Asn Val Tyr Lys Lys Leu Gly Pro Ile 165 170 175 Phe Asn Arg Ala Leu Val Ser Ala Thr Glu Phe Ala Asp Lys Leu Val 180 185 190 Glu Val Gly Leu Val Gly Val Leu Thr Leu Asp Asn Gln Asp Leu Asn 195 200 205 Gly Lys Trp Tyr Asp Phe Gly Asp Tyr Val Ile Ala Ala Pro Gly Cys 210 215 220 Gly Val Ala Ile Ala Asp Ser Tyr Tyr Ser Tyr Ile Met Pro Met Leu 225 230 235 240 Thr Met Cys His Ala Leu Asp Cys Glu Leu Tyr Val Asn Asn Ala Tyr 245 250 255 Arg Leu Phe Asp Leu Val Gln Tyr Asp Phe Thr Asp Tyr Lys Leu Glu 260 265 270 Leu Phe Asn Lys Tyr Phe Lys His Trp Ser Met Pro Tyr His Pro Asn 275 280 285 Thr Val Asp Cys Gln Asp Asp Arg Cys Ile Ile His Cys Ala Asn Phe 290 295 300 Asn Ile Leu Phe Ser Met Val Leu Pro Asn Thr Cys Phe Gly Pro Leu 305 310 315 320 Val Arg Gln Ile Phe Val Asp Gly Val Pro Phe Val Val Ser Ile Gly 325 330 335 Tyr His Tyr Lys Glu Leu Gly Ile Val Met Asn Met Asp Val Asp Thr 340 345 350 His Arg Tyr Arg Leu Ser Leu Lys Asp Leu Leu Leu Tyr Ala Ala Asp 355 360 365 Pro Ala Leu His Val Ala Ser Ala Ser Ala Leu Tyr Asp Leu Arg Thr 370 375 380 Cys Cys Phe Ser Val Ala Ala Ile Thr Ser Gly Val Lys Phe Gln Thr 385 390 395 400 Val Lys Pro Gly Asn Phe Asn Gln Asp Phe Tyr Asp Phe Val Leu Ser 405 410 415 Lys Gly Leu Leu Lys Glu Gly Ser Ser Val Asp Leu Lys His Phe Phe 420 425 430 Phe Thr Gln Asp Gly Asn Ala Ala Ile Thr Asp Tyr Asn Tyr Tyr Lys 435 440 445 Tyr Asn Leu Pro Thr Met Val Asp Ile Lys Gln Leu Leu Phe Val Leu 450 455 460 Glu Val Val Tyr Lys Tyr Phe Glu Ile Tyr Asp Gly Gly Cys Ile Pro 465 470 475 480 Ala Ser Gln Val Ile Val Asn Asn Tyr Asp Lys Ser Ala Gly Tyr Pro 485 490 495 Phe Asn Lys Phe Gly Lys Ala Arg Leu Tyr Tyr Glu Ala Leu Ser Phe 500 505 510 Glu Glu Gln Asp Glu Ile Tyr Ala Tyr Thr Lys Arg Asn Val Leu Pro 515 520 525 Thr Leu Thr Gln Met Asn Leu Lys Tyr Ala Ile Ser Ala Lys Asn Arg 530 535 540 Ala Arg Thr Val Ala Gly Val Ser Ile Leu Ser Thr Met Thr Gly Arg 545 550 555 560 Met Phe His Gln Lys Cys Leu Lys Ser Ile Ala Ala Thr Arg Gly Val 565 570 575 Pro Val Val Ile Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asp Asp Met 580 585 590 Leu Arg Arg Leu Ile Lys Asp Val Asp Asn Pro Val Leu Met Gly Trp 595 600 605 Asp Tyr Pro Lys Cys Asp Arg Ala Met Pro Asn Leu Leu Arg Ile Val 610 615 620 Ser Ser Leu Val Leu Ala Arg Lys His Glu Thr Cys Cys Ser Gln Ser 625 630 635 640 Asp Arg Phe Tyr Arg Leu Ala Asn Glu Cys Ala Gln Val Leu Ser Glu 645 650 655 Ile Val Met Cys Gly Gly Cys Tyr Tyr Val Lys Pro Gly Gly Thr Ser 660 665 670 Ser Gly Asp Ala Thr Thr Ala Phe Ala Asn Ser Val Phe Asn Ile Cys 675 680 685 Gln Ala Val Ser Ala Asn Val Cys Ala Leu Met Ser Cys Asn Gly Asn 690 695 700 Lys Ile Glu Asp Leu Ser Ile Arg Ala Leu Gln Lys Arg Leu Tyr Ser 705 710 715 720 His Val Tyr Arg Ser Asp Lys Val Asp Ser Thr Phe Val Thr Glu Tyr 725 730 735 Tyr Glu Phe Leu Asn Lys His Phe Ser Met Met Ile Leu Ser Asp Asp 740 745 750 Gly Val Val Cys Tyr Asn Ser Asp Tyr Ala Ser Lys Gly Tyr Ile Ala 755 760 765 Asn Ile Ser Ala Phe Gln Gln Val Leu Tyr Tyr Gln Asn Asn Val Phe 770 775 780 Met Ser Glu Ser Lys Cys Trp Val Glu His Asp Ile Asn Asn Gly Pro 785 790 795 800 His Glu Phe Cys Ser Gln His Thr Met Leu Val Lys Met Asp Gly Asp 805 810 815 Asp Val Tyr Leu Pro Tyr Pro Asn Pro Ser Arg Ile Leu Gly Ala Gly 820 825 830 Cys Phe Val Asp Asp Leu Leu Lys Thr Asp Ser Val Leu Leu Ile Glu 835 840 845 Arg Phe Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu Val Tyr His Glu 850 855 860 Asn Glu Glu Tyr Gln Lys Val Phe Arg Val Tyr Leu Ala Tyr Ile Lys 865 870 875 880 Lys Leu Tyr Asn Asp Leu Gly Asn Gln Ile Leu Asp Ser Tyr Ser Val 885 890 895 Ile Leu Ser Thr Cys Asp Gly Gln Lys Phe Thr Asp Glu Ser Phe Tyr 900 905 910 Lys Asn Met Tyr Leu Arg Ser Ala Val Met Gln Ser Val Gly Ala Cys 915 920 925 Val Val Cys Ser Ser Gln Thr Ser Leu Arg Cys Gly Ser Cys Ile Arg 930 935 940 Lys Pro Leu Leu Cys Cys Lys Cys Cys Tyr Asp His Val Met Ala Thr 945 950 955 960 Asp His Lys Tyr Val Leu Ser Val Ser Pro Tyr Val Cys Asn Ala Pro 965 970 975 Gly Cys Asp Val Asn Asp Val Thr Lys Leu Tyr Leu Gly Gly Met Ser 980 985 990 Tyr Tyr Cys Glu Asp His Lys Pro Gln Tyr Ser Phe Lys Leu Val Met 995 1000 1005 Asn Gly Leu Val Phe Gly Leu Tyr Lys Gln Ser Cys Thr Gly Ser 1010 1015 1020 Pro Tyr Ile Asp Asp Phe Asn Arg Ile Ala Ser Cys Lys Trp Thr 1025 1030 1035 Asp Val Asp Asp Tyr Ile Leu Ala Asn Glu Cys Thr Glu Arg Leu 1040 1045 1050 Lys Leu Phe Ala Ala Glu Thr Gln Lys Ala Thr Glu Glu Ala Phe 1055 1060 1065 Lys Gln Ser Tyr Ala Ser Ala Thr Ile Gln Glu Ile Val Ser Glu 1070 1075 1080 Arg Glu Leu Ile Leu Ser Trp Glu Ile Gly Lys Val Lys Pro Pro 1085 1090 1095 Leu Asn Lys Asn Tyr Val Phe Thr Gly Tyr His Phe Thr Lys Asn 1100 1105 1110 Gly Lys Thr Val Leu Gly Glu Tyr Val Phe Asp Lys Ser Glu Leu 1115 1120 1125 Thr Asn Gly Val Tyr Tyr Arg Ala Thr Thr Thr Tyr Lys Leu Ser 1130 1135 1140 Val Gly Asp Val Phe Val Leu Thr Ser His Ser Val Ala Asn Leu 1145 1150 1155 Ser Ala Pro Thr Leu Val Pro Gln Glu Asn Tyr Ser Ser Ile Arg 1160 1165 1170 Phe Ala Ser Val Tyr Ser Val Leu Glu Thr Phe Gln Asn Asn Val 1175 1180 1185 Val Asn Tyr Gln His Ile Gly Met Lys Arg Tyr Cys Thr Val Gln 1190 1195 1200 Gly Pro Pro Gly Thr Gly Lys Ser His Leu Ala Ile Gly Leu Ala 1205 1210 1215 Val Phe Tyr Cys Thr Ala Arg Val Val Tyr Thr Ala Ala Ser His 1220 1225 1230 Ala Ala Val Asp Ala Leu Cys Glu Lys Ala Tyr Lys Phe Leu Asn 1235 1240 1245 Ile Asn Asp Cys Thr Arg Ile Val Pro Ala Lys Val Arg Val Glu 1250 1255 1260 Cys Tyr Asp Lys Phe Lys Ile Asn Asp Thr Thr Arg Lys Tyr Val 1265 1270 1275 Phe Thr Thr Ile Asn Ala Leu Pro Glu Met Val Thr Asp Ile Val 1280 1285 1290 Val Val Asp Glu Val Ser Met Leu Thr Asn Tyr Glu Leu Ser Val 1295 1300 1305 Ile Asn Ala Arg Ile Arg Ala Lys His Tyr Val Tyr Ile Gly Asp 1310 1315 1320 Pro Ala Gln Leu Pro Ala Pro Arg Val Leu Leu Ser Lys Gly Thr 1325 1330 1335 Leu Glu Pro Lys Tyr Phe Asn Thr Val Thr Lys Leu Met Cys Cys 1340 1345 1350 Leu Gly Pro Asp Ile Phe Leu Gly Thr Cys Tyr Arg Cys Pro Lys 1355 1360 1365 Glu Ile Val Asp Thr Val Ser Ala Leu Val Tyr Glu Asn Lys Leu 1370 1375 1380 Lys Ala Lys Asn Glu Ser Ser Ser Leu Cys Phe Lys Val Tyr Tyr 1385 1390 1395 Lys Gly Val Thr Thr His Glu Ser Ser Ser Ala Val Asn Met Gln 1400 1405 1410 Gln Ile Tyr Leu Ile Asn Lys Phe Leu Lys Ala Asn Pro Leu Trp 1415 1420 1425 His Lys Ala Val Phe Ile Ser Pro Tyr Asn Ser Gln Asn Phe Ala 1430 1435 1440 Ala Lys Arg Val Leu Gly Leu Gln Thr Gln Thr Val Asp Ser Ala 1445 1450 1455 Gln Gly Ser Glu Tyr Asp Tyr Val Ile Tyr Ser Gln Thr Ala Glu 1460 1465 1470 Thr Ala His Ser Val Asn Val Asn Arg Phe Asn Val Ala Ile Thr 1475 1480 1485 Arg Ala Lys Lys Gly Ile Leu Cys Val Met Ser Asn Met Gln Leu 1490 1495 1500 Phe Glu Ala Leu Gln Phe Thr Thr Leu Thr Leu Asp Lys Val Pro 1505 1510 1515 Gln Ala Val Glu Thr Lys Val Gln Cys Ser Thr Asn Leu Phe Lys 1520 1525 1530 Asp Cys Ser Lys Ser Tyr Ser Gly Tyr His Pro Ala His Ala Pro 1535 1540 1545 Ser Phe Leu Ala Val Asp Asp Lys Tyr Lys Ala Thr Gly Asp Leu 1550 1555 1560 Ala Val Cys Leu Gly Ile Gly Asp Ser Ala Val Thr Tyr Ser Arg 1565 1570 1575 Leu Ile Ser Leu Met Gly Phe Lys Leu Asp Val Thr Leu Asp Gly 1580 1585 1590 Tyr Cys Lys Leu Phe Ile Thr Lys Glu Glu Ala Val Lys Arg Val 1595 1600 1605 Arg Ala Trp Val Gly Phe Asp Ala Glu Gly Ala His Ala Thr Arg 1610 1615 1620 Asp Ser Ile Gly Thr Asn Phe Pro Leu Gln Leu Gly Phe Ser Thr 1625 1630 1635 Gly Ile Asp Phe Val Val Glu Ala Thr Gly Leu Phe Ala Asp Arg 1640 1645 1650 Asp Gly Tyr Ser Phe Lys Lys Ala Val Ala Lys Ala Pro Pro Gly 1655 1660 1665 Glu Gln Phe Lys His Leu Ile Pro Leu Met Thr Arg Gly His Arg 1670 1675 1680 Trp Asp Val Val Arg Pro Arg Ile Val Gln Met Phe Ala Asp His 1685 1690 1695 Leu Ile Asp Leu Ser Asp Cys Val Val Leu Val Thr Trp Ala Ala 1700 1705 1710 Asn Phe Glu Leu Thr Cys Leu Arg Tyr Phe Ala Lys Val Gly Arg 1715 1720 1725 Glu Ile Ser Cys Asn Val Cys Thr Lys Arg Ala Thr Val Tyr Asn 1730 1735 1740 Ser Arg Thr Gly Tyr Tyr Gly Cys Trp Arg His Ser Val Thr Cys 1745 1750 1755 Asp Tyr Leu Tyr Asn Pro Leu Ile Val Asp Ile Gln Gln Trp Gly 1760 1765 1770 Tyr Ile Gly Ser Leu Ser Ser Asn His Asp Leu Tyr Cys Ser Val 1775 1780 1785 His Lys Gly Ala His Val Ala Ser Ser Asp Ala Ile Met Thr Arg 1790 1795 1800 Cys Leu Ala Val Tyr Asp Cys Phe Cys Asn Asn Ile Asn Trp Asn 1805 1810 1815 Val Glu Tyr Pro Ile Ile Ser Asn Glu Leu Ser Ile Asn Thr Ser 1820 1825 1830 Cys Arg Val Leu Gln Arg Val Ile Leu Lys Ala Ala Met Leu Cys 1835 1840 1845 Asn Arg Tyr Thr Leu Cys Tyr Asp Ile Gly Asn Pro Lys Ala Ile 1850 1855 1860 Ala Cys Val Lys Asp Phe Asp Phe Lys Phe Tyr Asp Ala Gln Pro 1865 1870 1875 Ile Val Lys Ser Val Lys Thr Leu Leu Tyr Ser Phe Glu Ala His 1880 1885 1890 Lys Asp Ser Phe Lys Asp Gly Leu Cys Met Phe Trp Asn Cys Asn 1895 1900 1905 Val Asp Lys Tyr Pro Pro Asn Ala Val Val Cys Arg Phe Asp Thr 1910 1915 1920 Arg Val Leu Asn Asn Leu Asn Leu Pro Gly Cys Asn Gly Gly Ser 1925 1930 1935 Leu Tyr Val Asn Lys His Ala Phe His Thr Lys Pro Phe Ala Arg 1940 1945 1950 Ala Ala Phe Glu His Leu Lys Pro Met Pro Phe Phe Tyr Tyr Ser 1955 1960 1965 Asp Thr Pro Cys Val Tyr Met Asp Gly Met Asp Ala Lys Gln Val 1970 1975 1980 Asp Tyr Val Pro Leu Lys Ser Ala Thr Cys Ile Thr Arg Cys Asn 1985 1990 1995 Leu Gly Gly Ala Val Cys Leu Lys His Ala Glu Glu Tyr Arg Glu 2000 2005 2010 Tyr Leu Glu Ser Tyr Asn Thr Ala Thr Thr Ala Gly Phe Thr Phe 2015 2020 2025 Trp Val Tyr Lys Thr Phe Asp Phe Tyr Asn Leu Trp Asn Thr Phe 2030 2035 2040 Thr Lys Leu Gln Ser Leu Glu Asn Val Val Tyr Asn Leu Val Lys 2045 2050 2055 Thr Gly His Tyr Thr Gly Gln Ala Gly Glu Met Pro Cys Ala Ile 2060 2065 2070 Ile Asn Asp Lys Val Val Ala Lys Ile Asp Lys Glu Asp Val Val 2075 2080 2085 Ile Phe Ile Asn Asn Thr Thr Tyr Pro Thr Asn Val Ala Val Glu 2090 2095 2100 Leu Phe Ala Lys Arg Ser Val Arg His His Pro Glu Leu Lys Leu 2105 2110 2115 Phe Arg Asn Leu Asn Ile Asp Val Cys Trp Lys His Val Ile Trp 2120 2125 2130 Asp Tyr Ala Arg Glu Ser Ile Phe Cys Ser Asn Thr Tyr Gly Val 2135 2140 2145 Cys Met Tyr Thr Asp Leu Lys Phe Ile Asp Lys Leu Asn Val Leu 2150 2155 2160 Phe Asp Gly Arg Asp Asn Gly Ala Leu Glu Ala Phe Lys Arg Ser 2165 2170 2175 Asn Asn Gly Val Tyr Ile Ser Thr Thr Lys Val Lys Ser Leu Ser 2180 2185 2190 Met Ile Arg Gly Pro Pro Arg Ala Glu Leu Asn Gly Val Val Val 2195 2200 2205 Asp Lys Val Gly Asp Thr Asp Cys Val Phe Tyr Phe Ala Val Arg 2210 2215 2220 Lys Glu Gly Gln Asp Val Ile Phe Ser Gln Phe Asp Ser Leu Gly 2225 2230 2235 Val Ser Ser Asn Gln Ser Pro Gln Gly Asn Leu Gly Ser Asn Gly 2240 2245 2250 Lys Pro Gly Asn Val Gly Gly Asn Asp Ala Leu Ser Ile Ser Thr 2255 2260 2265 Ile Phe Thr Gln Ser Arg Val Ile Ser Ser Phe Thr Cys Arg Thr 2270 2275 2280 Asp Met Glu Lys Asp Phe Ile Ala Leu Asp Gln Asp Val Phe Ile 2285 2290 2295 Gln Lys Tyr Gly Leu Glu Asp Tyr Ala Phe Glu His Ile Val Tyr 2300 2305 2310 Gly Asn Phe Asn Gln Lys Ile Ile Gly Gly Leu His Leu Leu Ile 2315 2320 2325 Gly Leu Tyr Arg Arg Gln Gln Thr Ser Asn Leu Val Val Gln Glu 2330 2335 2340 Phe Val Ser Tyr Asp Ser Ser Ile His Ser Tyr Phe Ile Thr Asp 2345 2350 2355 Glu Lys Ser Gly Gly Ser Lys Ser Val Cys Thr Val Ile Asp Ile 2360 2365 2370 Leu Leu Asp Asp Phe Val Ala Leu Val Lys Ser Leu Asn Leu Asn 2375 2380 2385 Cys Val Ser Lys Val Val Asn Val Asn Val Asp Phe Lys Asp Phe 2390 2395 2400 Gln Phe Met Leu Trp Cys Asn Asp Glu Lys Val Met Thr Phe Tyr 2405 2410 2415 Pro Arg Leu Gln Ala Ala Ser Asp Trp Lys Pro Gly Tyr Ser Met 2420 2425 2430 Pro Val Leu Tyr Lys Tyr Leu Asn Ser Pro Met Glu Arg Val Ser 2435 2440 2445 Leu Trp Asn Tyr Gly Lys Pro Val Thr Leu Pro Thr Gly Cys Met 2450 2455 2460 Met Asn Val Ala Lys Tyr Thr Gln Leu Cys Gln Tyr Leu Asn Thr 2465 2470 2475 Thr Thr Leu Ala Val Pro Val Asn Met Arg Val Leu His Leu Gly 2480 2485 2490 Ala Gly Ser Glu Lys Gly Val Ala Pro Gly Ser Ala Val Leu Arg 2495 2500 2505 Gln Trp Leu Pro Ala Gly Thr Ile Leu Val Asp Asn Asp Leu Tyr 2510 2515 2520 Pro Phe Val Ser Asp Ser Val Ala Thr Tyr Phe Gly Asp Cys Ile 2525 2530 2535 Thr Leu Pro Phe Asp Cys Gln Trp Asp Leu Ile Ile Ser Asp Met 2540 2545 2550 Tyr Asp Pro Ile Thr Lys Asn Ile Gly Glu Tyr Asn Val Ser Lys 2555 2560 2565 Asp Gly Phe Phe Thr Tyr Ile Cys His Met Ile Arg Asp Lys Leu 2570 2575 2580 Ala Leu Gly Gly Ser Val Ala Ile Lys Ile Thr Glu Phe Ser Trp 2585 2590 2595 Asn Ala Glu Leu Tyr Lys Leu Met Gly Tyr Phe Ala Phe Trp Thr 2600 2605 2610 Val Phe Cys Thr Asn Ala Asn Ala Ser Ser Ser Glu Gly Phe Leu 2615 2620 2625 Ile Gly Ile Asn Tyr Leu Cys Lys Pro Lys Val Glu Ile Asp Gly 2630 2635 2640 Asn Val Met His Ala Asn Tyr Leu Phe Trp Arg Asn Ser Thr Val 2645 2650 2655 Trp Asn Gly Gly Ala Tyr Ser Leu Phe Asp Met Ala Lys Phe Pro 2660 2665 2670 Leu Lys Leu Ala Gly Thr Ala Val Ile Asn Leu Arg Ala Asp Gln 2675 2680 2685 Ile Asn Asp Met Val Tyr Ser Leu Leu Glu Lys Gly Lys Leu Leu 2690 2695 2700 Ile Arg Asp Thr Asn Lys Glu Val Phe Val Gly Asp Ser Leu Val 2705 2710 2715 Asn Val Ile 2720 <210> 90 <211> 2678 <212> PRT <213> porcine epidemic diarrhea virus <220> <221> MISC_FEATURE <223> ORF 1B <400> 90 Tyr Gly Leu Phe Lys Arg Val Arg Gly Ser Ser Ala Ala Arg Leu Glu 1 5 10 15 Pro Cys Asn Gly Thr Asp Thr Gln His Val Tyr Arg Ala Phe Asp Ile 20 25 30 Tyr Asn Lys Asp Val Ala Cys Leu Gly Lys Phe Leu Lys Val Asn Cys 35 40 45 Val Arg Leu Lys Asn Leu Asp Lys His Asp Ala Phe Tyr Val Val Lys 50 55 60 Arg Cys Thr Lys Ser Ala Met Glu His Glu Gln Ser Ile Tyr Ser Arg 65 70 75 80 Leu Glu Lys Cys Gly Ala Ile Ala Glu His Asp Phe Phe Thr Trp Lys 85 90 95 Asp Gly Arg Ala Ile Tyr Gly Asn Val Cys Arg Lys Asp Leu Thr Glu 100 105 110 Tyr Thr Met Met Asp Leu Cys Tyr Ala Leu Arg Asn Phe Asp Glu Asn 115 120 125 Asn Cys Asp Val Leu Lys Ser Ile Leu Ile Lys Val Gly Ala Cys Glu 130 135 140 Glu Ser Tyr Phe Asn Asn Lys Val Trp Phe Asp Pro Val Glu Asn Glu 145 150 155 160 Asp Ile His Arg Val Tyr Ala Leu Leu Gly Thr Ile Val Ala Arg Ala 165 170 175 Met Leu Lys Cys Val Lys Phe Cys Asp Ala Met Val Glu Gln Gly Ile 180 185 190 Val Gly Val Val Thr Leu Asp Asn Gln Asp Leu Asn Gly Asp Phe Tyr 195 200 205 Asp Phe Gly Asp Phe Thr Cys Ser Ile Lys Gly Met Gly Val Pro Ile 210 215 220 Cys Thr Ser Tyr Tyr Ser Tyr Met Met Pro Val Met Gly Met Thr Asn 225 230 235 240 Cys Leu Ala Ser Glu Cys Phe Val Lys Ser Asp Ile Phe Gly Glu Asp 245 250 255 Phe Lys Ser Tyr Asp Leu Leu Glu Tyr Asp Phe Thr Glu His Lys Thr 260 265 270 Ala Leu Phe Asn Lys Tyr Phe Lys Tyr Trp Gly Leu Gln Tyr His Pro 275 280 285 Asn Cys Val Asp Cys Ser Asp Glu Gln Cys Ile Val His Cys Ala Asn 290 295 300 Phe Asn Thr Leu Phe Ser Thr Thr Ile Pro Ile Thr Ala Phe Gly Pro 305 310 315 320 Leu Cys Arg Lys Cys Trp Ile Asp Gly Val Pro Leu Val Thr Thr Ala 325 330 335 Gly Tyr His Phe Lys Gln Leu Gly Ile Val Trp Asn Asn Asp Leu Asn 340 345 350 Leu His Ser Ser Arg Leu Ser Ile Asn Glu Leu Leu Gln Phe Cys Ser 355 360 365 Asp Pro Ala Leu Leu Ile Ala Ser Ser Pro Ala Leu Val Asp Gln Arg 370 375 380 Thr Val Cys Phe Ser Val Ala Ala Leu Gly Thr Gly Met Thr Asn Gln 385 390 395 400 Thr Val Lys Pro Gly His Phe Asn Lys Glu Phe Tyr Asp Phe Leu Leu 405 410 415 Glu Gln Gly Phe Phe Ser Glu Gly Ser Glu Leu Thr Leu Lys His Phe 420 425 430 Phe Phe Ala Gln Lys Val Asp Ala Ala Val Lys Asp Phe Asp Tyr Tyr 435 440 445 Arg Tyr Asn Arg Pro Thr Val Leu Asp Ile Cys Gln Ala Arg Val Val 450 455 460 Tyr Gln Ile Val Gln Arg Tyr Phe Asp Ile Tyr Glu Gly Gly Cys Ile 465 470 475 480 Thr Ala Lys Glu Val Val Val Thr Asn Leu Asn Lys Ser Ala Gly Tyr 485 490 495 Pro Leu Asn Lys Phe Gly Lys Ala Gly Leu Tyr Tyr Glu Ser Leu Ser 500 505 510 Tyr Glu Glu Gln Asp Glu Leu Tyr Ala Tyr Thr Lys Arg Asn Ile Leu 515 520 525 Pro Thr Met Thr Gln Leu Asn Leu Lys Tyr Ala Ile Ser Gly Lys Glu 530 535 540 Arg Ala Arg Thr Val Gly Gly Val Ser Leu Leu Ser Thr Met Thr Thr 545 550 555 560 Arg Gln Tyr His Gln Lys His Leu Lys Ser Ile Val Asn Thr Arg Gly 565 570 575 Ala Ser Val Val Ile Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asp Asn 580 585 590 Met Leu Lys Asn Leu Ile Asp Gly Val Glu Asn Pro Cys Leu Met Gly 595 600 605 Trp Asp Tyr Pro Lys Cys Asp Arg Ala Leu Pro Asn Met Ile Arg Met 610 615 620 Ile Ser Ala Met Ile Leu Gly Ser Lys His Thr Thr Cys Cys Ser Ser 625 630 635 640 Thr Asp Arg Phe Phe Arg Leu Cys Asn Glu Leu Ala Gln Val Leu Thr 645 650 655 Glu Val Val Tyr Ser Asn Gly Gly Phe Tyr Leu Lys Pro Gly Gly Thr 660 665 670 Thr Ser Gly Asp Ala Thr Thr Ala Tyr Ala Asn Ser Val Phe Asn Ile 675 680 685 Phe Gln Ala Val Ser Ala Asn Val Asn Lys Leu Leu Ser Val Asp Ser 690 695 700 Asn Val Cys His Asn Leu Glu Val Lys Gln Leu Gln Arg Lys Leu Tyr 705 710 715 720 Glu Cys Cys Tyr Arg Ser Thr Ile Val Asp Asp Gln Phe Val Val Glu 725 730 735 Tyr Tyr Gly Tyr Leu Arg Lys His Phe Ser Met Met Ile Leu Ser Asp 740 745 750 Asp Gly Val Val Cys Tyr Asn Asn Asp Tyr Ala Ser Leu Gly Tyr Val 755 760 765 Ala Asp Leu Asn Ala Phe Lys Ala Val Leu Tyr Tyr Gln Asn Asn Val 770 775 780 Phe Met Ser Ala Ser Lys Cys Trp Ile Glu Pro Asp Ile Asn Lys Gly 785 790 795 800 Pro His Glu Phe Cys Ser Gln His Thr Met Gln Ile Val Asp Lys Glu 805 810 815 Gly Thr Tyr Tyr Leu Pro Tyr Pro Asp Pro Ser Arg Ile Leu Ser Ala 820 825 830 Gly Val Phe Val Asp Asp Val Val Lys Thr Asp Ala Val Val Leu Leu 835 840 845 Glu Arg Tyr Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu Ser Lys His 850 855 860 Glu Asn Pro Glu Tyr Lys Lys Val Phe Tyr Val Leu Leu Asp Trp Val 865 870 875 880 Lys His Leu Tyr Lys Thr Leu Asn Ala Gly Val Leu Glu Ser Phe Ser 885 890 895 Val Thr Leu Leu Glu Asp Ser Thr Ala Lys Phe Trp Asp Glu Ser Phe 900 905 910 Tyr Ala Asn Met Tyr Glu Lys Ser Ala Val Leu Gln Ser Ala Gly Leu 915 920 925 Cys Val Val Cys Gly Ser Gln Thr Val Leu Arg Cys Gly Asp Cys Leu 930 935 940 Arg Arg Pro Met Leu Cys Thr Lys Cys Ala Tyr Asp His Val Ile Gly 945 950 955 960 Thr Thr His Lys Phe Ile Leu Ala Ile Thr Pro Tyr Val Cys Cys Ala 965 970 975 Ser Asp Cys Gly Val Asn Asp Val Thr Lys Leu Tyr Leu Gly Gly Leu 980 985 990 Ser Tyr Trp Cys His Glu His Lys Pro Arg Leu Ala Phe Pro Leu Cys 995 1000 1005 Ser Ala Gly Asn Val Phe Gly Leu Tyr Lys Asn Ser Ala Thr Gly 1010 1015 1020 Ser Pro Asp Val Glu Asp Phe Asn Arg Ile Ala Thr Ser Asp Trp 1025 1030 1035 Thr Asp Val Ser Asp Tyr Arg Leu Ala Asn Asp Val Lys Asp Ser 1040 1045 1050 Leu Arg Leu Phe Ala Ala Glu Thr Ile Lys Ala Lys Glu Glu Ser 1055 1060 1065 Val Lys Ser Ser Tyr Ala Cys Ala Thr Leu His Glu Val Val Gly 1070 1075 1080 Pro Lys Glu Leu Leu Leu Lys Trp Glu Val Gly Arg Pro Lys Pro 1085 1090 1095 Pro Leu Asn Arg Asn Ser Val Phe Thr Cys Tyr His Ile Thr Lys 1100 1105 1110 Asn Thr Lys Phe Gln Ile Gly Glu Phe Val Phe Glu Lys Ala Glu 1115 1120 1125 Tyr Asp Asn Asp Ala Val Thr Tyr Lys Thr Thr Ala Thr Thr Lys 1130 1135 1140 Leu Val Pro Gly Met Val Phe Val Leu Thr Ser His Asn Val Gln 1145 1150 1155 Pro Leu Arg Ala Pro Thr Ile Ala Asn Gln Glu Arg Tyr Ser Thr 1160 1165 1170 Ile His Lys Leu His Pro Ala Phe Asn Ile Pro Glu Ala Tyr Ser 1175 1180 1185 Ser Leu Val Pro Tyr Tyr Gln Leu Ile Gly Lys Gln Lys Ile Thr 1190 1195 1200 Thr Ile Gln Gly Pro Pro Gly Ser Gly Lys Ser His Cys Val Ile 1205 1210 1215 Gly Leu Gly Leu Tyr Tyr Pro Gly Ala Arg Ile Val Phe Thr Ala 1220 1225 1230 Cys Ser His Ala Ala Val Asp Ser Leu Cys Val Lys Ala Ser Thr 1235 1240 1245 Ala Tyr Ser Asn Asp Lys Cys Ser Arg Ile Ile Pro Gln Arg Ala 1250 1255 1260 Arg Val Glu Cys Tyr Asp Gly Phe Lys Ser Asn Asn Thr Ser Ala 1265 1270 1275 Gln Tyr Leu Phe Ser Thr Val Asn Ala Leu Pro Glu Cys Asn Ala 1280 1285 1290 Asp Ile Val Val Val Asp Glu Val Ser Met Cys Thr Asn Tyr Asp 1295 1300 1305 Leu Ser Val Ile Asn Gln Arg Ile Ser Tyr Arg His Val Val Tyr 1310 1315 1320 Val Gly Asp Pro Gln Gln Leu Pro Ala Pro Arg Val Met Ile Ser 1325 1330 1335 Arg Gly Thr Leu Glu Pro Lys Asp Tyr Asn Val Val Thr Gln Arg 1340 1345 1350 Met Cys Ala Leu Lys Pro Asp Val Phe Leu His Lys Cys Tyr Arg 1355 1360 1365 Cys Pro Ala Glu Ile Val Arg Thr Val Ser Glu Met Val Tyr Glu 1370 1375 1380 Asn Gln Phe Ile Pro Val His Pro Asp Ser Lys Gln Cys Phe Lys 1385 1390 1395 Ile Phe Cys Lys Gly Asn Val Gln Val Asp Asn Gly Ser Ser Ile 1400 1405 1410 Asn Arg Arg Gln Leu Asp Val Val Arg Met Phe Leu Ala Lys Asn 1415 1420 1425 Pro Arg Trp Ser Lys Ala Val Phe Ile Ser Pro Tyr Asn Ser Gln 1430 1435 1440 Asn Tyr Val Ala Ser Arg Leu Leu Gly Leu Gln Ile Gln Thr Val 1445 1450 1455 Asp Ser Ser Gln Gly Ser Glu Tyr Asp Tyr Val Ile Tyr Ala Gln 1460 1465 1470 Thr Ser Asp Thr Ala His Ala Ser Asn Val Asn Arg Phe Asn Val 1475 1480 1485 Ala Ile Thr Arg Ala Lys Lys Gly Ile Leu Cys Ile Met Cys Asp 1490 1495 1500 Arg Ser Leu Phe Asp Leu Leu Lys Phe Phe Glu Leu Lys Leu Ser 1505 1510 1515 Asp Leu Gln Ala Asn Glu Gly Cys Gly Leu Phe Lys Asp Cys Ser 1520 1525 1530 Arg Gly Asp Asp Leu Leu Pro Pro Ser His Ala Asn Thr Phe Met 1535 1540 1545 Ser Leu Ala Asp Asn Phe Lys Thr Asp Gln Tyr Leu Ala Val Gln 1550 1555 1560 Ile Gly Val Asn Gly Pro Ile Lys Tyr Glu His Val Ile Ser Phe 1565 1570 1575 Met Gly Phe Arg Phe Asp Ile Asn Ile Pro Asn His His Thr Leu 1580 1585 1590 Phe Cys Thr Arg Asp Phe Ala Met Arg Asn Val Arg Gly Trp Leu 1595 1600 1605 Gly Phe Asp Val Glu Gly Ala His Val Val Gly Ser Asn Val Gly 1610 1615 1620 Thr Asn Val Pro Leu Gln Leu Gly Phe Ser Asn Gly Val Asp Phe 1625 1630 1635 Val Val Arg Pro Glu Gly Cys Val Val Thr Glu Ser Gly Asp Tyr 1640 1645 1650 Ile Lys Pro Val Arg Ala Arg Ala Pro Pro Gly Glu Gln Phe Ala 1655 1660 1665 His Leu Leu Pro Leu Leu Lys Arg Gly Gln Pro Trp Asp Val Val 1670 1675 1680 Arg Lys Arg Ile Val Gln Met Cys Ser Asp Tyr Leu Ala Asn Leu 1685 1690 1695 Ser Asp Ile Leu Ile Phe Val Leu Trp Ala Gly Gly Leu Glu Leu 1700 1705 1710 Thr Thr Met Arg Tyr Phe Val Lys Ile Gly Pro Ser Lys Ser Cys 1715 1720 1725 Asp Cys Gly Lys Val Ala Thr Cys Tyr Asn Ser Ala Leu His Thr 1730 1735 1740 Tyr Cys Cys Phe Lys His Ala Leu Gly Cys Asp Tyr Leu Tyr Asn 1745 1750 1755 Pro Tyr Cys Ile Asp Ile Gln Gln Trp Gly Tyr Lys Gly Ser Leu 1760 1765 1770 Ser Leu Asn His His Glu His Cys Asn Val His Arg Asn Glu His 1775 1780 1785 Val Ala Ser Gly Asp Ala Ile Met Thr Arg Cys Leu Ala Ile His 1790 1795 1800 Asp Cys Phe Val Lys Asn Val Asp Trp Ser Ile Thr Tyr Pro Phe 1805 1810 1815 Ile Gly Asn Glu Ala Val Ile Asn Lys Ser Gly Arg Ile Val Gln 1820 1825 1830 Ser His Thr Met Arg Ser Val Leu Lys Leu Tyr Asn Pro Lys Ala 1835 1840 1845 Ile Tyr Asp Ile Gly Asn Pro Lys Gly Ile Arg Cys Ala Val Thr 1850 1855 1860 Asp Ala Lys Trp Phe Cys Phe Asp Lys Asn Pro Thr Asn Ser Asn 1865 1870 1875 Val Lys Thr Leu Glu Tyr Asp Tyr Ile Thr His Gly Gln Phe Asp 1880 1885 1890 Gly Leu Cys Leu Phe Trp Asn Cys Asn Val Asp Met Tyr Pro Glu 1895 1900 1905 Phe Ser Val Val Cys Arg Phe Asp Thr Arg Cys Arg Ser Pro Leu 1910 1915 1920 Asn Leu Glu Gly Cys Asn Gly Gly Ser Leu Tyr Val Asn Asn His 1925 1930 1935 Ala Phe His Thr Pro Ala Phe Asp Lys Arg Ala Phe Ala Lys Leu 1940 1945 1950 Lys Pro Met Pro Phe Phe Phe Tyr Asp Asp Thr Glu Cys Asp Lys 1955 1960 1965 Leu Gln Asp Ser Ile Asn Tyr Val Pro Leu Arg Ala Ser Asn Cys 1970 1975 1980 Ile Thr Lys Cys Asn Val Gly Gly Ala Val Cys Ser Lys His Cys 1985 1990 1995 Ala Met Tyr His Ser Tyr Val Asn Ala Tyr Asn Thr Phe Thr Ser 2000 2005 2010 Ala Gly Phe Thr Ile Trp Val Pro Thr Ser Phe Asp Thr Tyr Asn 2015 2020 2025 Leu Trp Gln Thr Phe Ser Asn Asn Leu Gln Gly Leu Glu Asn Ile 2030 2035 2040 Ala Phe Asn Val Leu Lys Lys Gly Ser Phe Val Gly Asp Glu Gly 2045 2050 2055 Glu Leu Pro Val Ala Val Val Asn Asp Lys Val Leu Val Arg Asp 2060 2065 2070 Gly Thr Val Asp Thr Leu Val Phe Thr Asn Lys Thr Ser Leu Pro 2075 2080 2085 Thr Asn Val Ala Phe Glu Leu Tyr Ala Lys Arg Lys Val Gly Leu 2090 2095 2100 Thr Pro Pro Ile Thr Ile Leu Arg Asn Leu Gly Val Val Cys Thr 2105 2110 2115 Ser Lys Cys Val Ile Trp Asp Tyr Glu Ala Glu Arg Pro Leu Thr 2120 2125 2130 Thr Phe Thr Lys Asp Val Cys Lys Tyr Thr Asp Phe Glu Gly Asp 2135 2140 2145 Val Cys Thr Leu Phe Asp Asn Ser Ile Val Gly Ser Leu Glu Arg 2150 2155 2160 Phe Ser Met Thr Gln Asn Ala Val Leu Met Ser Leu Thr Ala Val 2165 2170 2175 Lys Lys Leu Thr Gly Ile Lys Leu Thr Tyr Gly Tyr Leu Asn Gly 2180 2185 2190 Val Pro Val Asn Thr His Glu Asp Lys Pro Phe Thr Trp Tyr Ile 2195 2200 2205 Tyr Thr Arg Lys Asn Gly Lys Phe Glu Asp Tyr Pro Asp Gly Tyr 2210 2215 2220 Phe Thr Gln Gly Arg Thr Thr Ala Asp Phe Ser Pro Arg Ser Asp 2225 2230 2235 Met Glu Lys Asp Phe Leu Ser Met Asp Met Gly Leu Phe Ile Asn 2240 2245 2250 Lys Tyr Gly Leu Glu Asp Tyr Gly Phe Glu His Val Val Tyr Gly 2255 2260 2265 Asp Val Ser Lys Thr Thr Leu Gly Gly Leu His Leu Leu Ile Ser 2270 2275 2280 Gln Val Arg Leu Ala Cys Met Gly Val Leu Lys Ile Asp Glu Phe 2285 2290 2295 Val Ser Ser Asn Asp Ser Thr Leu Lys Ser Cys Thr Val Thr Tyr 2300 2305 2310 Ala Asp Asn Pro Ser Ser Lys Met Val Cys Thr Tyr Met Asp Leu 2315 2320 2325 Leu Leu Asp Asp Phe Val Ser Ile Leu Lys Ser Leu Asp Leu Ser 2330 2335 2340 Val Val Ser Lys Val His Glu Val Met Val Asp Cys Lys Met Trp 2345 2350 2355 Arg Trp Met Leu Trp Cys Lys Asp His Lys Leu Gln Thr Phe Tyr 2360 2365 2370 Pro Gln Leu Gln Ala Ser Glu Trp Lys Cys Gly Tyr Ser Met Pro 2375 2380 2385 Ser Ile Tyr Lys Ile Gln Arg Met Cys Leu Glu Pro Cys Asn Leu 2390 2395 2400 Tyr Asn Tyr Gly Ala Gly Val Lys Leu Pro Asp Gly Ile Met Phe 2405 2410 2415 Asn Val Val Lys Tyr Thr Gln Leu Cys Gln Tyr Leu Asn Ser Thr 2420 2425 2430 Thr Met Cys Val Pro His His Met Arg Val Leu His Leu Gly Ala 2435 2440 2445 Gly Ser Asp Lys Gly Val Ala Pro Gly Thr Ala Val Leu Arg Arg 2450 2455 2460 Trp Leu Pro Leu Asp Ala Ile Ile Val Asp Asn Asp Ser Val Asp 2465 2470 2475 Tyr Val Ser Asp Ala Asp Tyr Ser Val Thr Gly Asp Cys Ser Thr 2480 2485 2490 Leu Tyr Leu Ser Asp Lys Phe Asp Leu Val Ile Ser Asp Met Tyr 2495 2500 2505 Asp Gly Lys Ile Lys Ser Cys Asp Gly Glu Asn Val Ser Lys Glu 2510 2515 2520 Gly Phe Phe Pro Tyr Ile Asn Gly Val Ile Thr Glu Lys Leu Ala 2525 2530 2535 Leu Gly Gly Thr Val Ala Ile Lys Val Thr Glu Phe Ser Trp Asn 2540 2545 2550 Lys Lys Leu Tyr Glu Leu Ile Gln Lys Phe Glu Tyr Trp Thr Met 2555 2560 2565 Phe Cys Thr Ser Val Asn Thr Ser Ser Ser Glu Ala Phe Leu Ile 2570 2575 2580 Gly Val His Tyr Leu Gly Asp Phe Ala Ser Gly Ala Val Ile Asp 2585 2590 2595 Gly Asn Thr Met His Ala Asn Tyr Ile Phe Trp Arg Asn Ser Thr 2600 2605 2610 Ile Met Thr Met Ser Tyr Asn Ser Val Leu Asp Leu Ser Lys Phe 2615 2620 2625 Asn Cys Lys His Lys Ala Thr Val Val Val Asn Leu Lys Asp Ser 2630 2635 2640 Ser Ile Ser Asp Val Val Leu Gly Leu Leu Lys Asn Gly Lys Leu 2645 2650 2655 Leu Val Arg Asn Asn Asp Ala Ile Cys Gly Phe Ser Asn His Leu 2660 2665 2670 Val Asn Val Asn Lys 2675 <210> 91 <211> 2672 <212> PRT <213> human coronavirus 229E <220> <221> MISC_FEATURE <223> ORF 1B <400> 91 Glu Pro Cys Asn Gly Thr Asp Ile Asp Tyr Cys Val Arg Ala Phe Asp 1 5 10 15 Val Tyr Asn Lys Asp Ala Ser Phe Ile Gly Lys Asn Leu Lys Ser Asn 20 25 30 Cys Val Arg Phe Lys Asn Val Asp Lys Asp Asp Ala Phe Tyr Ile Val 35 40 45 Lys Arg Cys Ile Lys Ser Val Met Asp His Glu Gln Ser Met Tyr Asn 50 55 60 Leu Leu Lys Gly Cys Asn Ala Val Ala Lys His Asp Phe Phe Thr Trp 65 70 75 80 His Glu Gly Arg Thr Ile Tyr Gly Asn Val Ser Arg Gln Asp Leu Thr 85 90 95 Lys Tyr Thr Met Met Asp Leu Cys Phe Ala Leu Arg Asn Phe Asp Glu 100 105 110 Lys Asp Cys Glu Val Phe Lys Glu Ile Leu Val Leu Thr Gly Cys Cys 115 120 125 Ser Thr Asp Tyr Phe Glu Met Lys Asn Trp Phe Asp Pro Ile Glu Asn 130 135 140 Glu Asp Ile His Arg Val Tyr Ala Ala Leu Gly Lys Val Val Ala Asn 145 150 155 160 Ala Met Leu Lys Cys Val Ala Phe Cys Asp Glu Met Val Leu Lys Gly 165 170 175 Val Val Gly Val Leu Thr Leu Asp Asn Gln Asp Leu Asn Gly Asn Phe 180 185 190 Tyr Asp Phe Gly Asp Phe Val Leu Cys Pro Pro Gly Met Gly Ile Pro 195 200 205 Tyr Cys Thr Ser Tyr Tyr Ser Tyr Met Met Pro Val Met Gly Met Thr 210 215 220 Asn Cys Leu Ala Ser Glu Cys Phe Met Lys Ser Asp Ile Phe Gly Gln 225 230 235 240 Asp Phe Lys Thr Phe Asp Leu Leu Lys Tyr Asp Phe Thr Glu His Lys 245 250 255 Glu Val Leu Phe Asn Lys Tyr Phe Lys Tyr Trp Gly Gln Asp Tyr His 260 265 270 Pro Asp Cys Val Asp Cys His Asp Glu Met Cys Ile Leu His Cys Ser 275 280 285 Asn Phe Asn Thr Leu Phe Ala Thr Thr Ile Pro Asn Thr Ala Phe Gly 290 295 300 Pro Leu Cys Arg Lys Val Phe Ile Asp Gly Val Pro Val Val Ala Thr 305 310 315 320 Ala Gly Tyr His Phe Lys Gln Leu Gly Leu Val Trp Asn Lys Asp Val 325 330 335 Asn Thr His Ser Thr Arg Leu Thr Ile Thr Glu Leu Leu Gln Phe Val 340 345 350 Thr Asp Pro Thr Leu Ile Val Ala Ser Ser Pro Ala Leu Val Asp Lys 355 360 365 Arg Thr Val Cys Phe Ser Val Ala Ala Leu Ser Thr Gly Leu Thr Ser 370 375 380 Gln Thr Val Lys Pro Gly His Phe Asn Lys Glu Phe Tyr Asp Phe Leu 385 390 395 400 Arg Ser Gln Gly Phe Phe Asp Glu Gly Ser Glu Leu Thr Leu Lys His 405 410 415 Phe Phe Phe Thr Gln Lys Gly Asp Ala Ala Ile Lys Asp Phe Asp Tyr 420 425 430 Tyr Arg Tyr Asn Arg Pro Thr Met Leu Asp Ile Gly Gln Ala Arg Val 435 440 445 Ala Tyr Gln Val Ala Ala Arg Tyr Phe Asp Cys Tyr Glu Gly Gly Cys 450 455 460 Ile Thr Ser Arg Glu Val Val Val Thr Asn Leu Asn Lys Ser Ala Gly 465 470 475 480 Trp Pro Leu Asn Lys Phe Gly Lys Ala Gly Leu Tyr Tyr Glu Ser Ile 485 490 495 Ser Tyr Glu Glu Gln Asp Ala Ile Phe Ser Leu Thr Lys Arg Asn Ile 500 505 510 Leu Pro Thr Met Thr Gln Leu Asn Leu Lys Tyr Ala Ile Ser Gly Lys 515 520 525 Glu Arg Ala Arg Thr Val Gly Gly Val Ser Leu Leu Ala Thr Met Thr 530 535 540 Thr Arg Gln Phe His Gln Lys Cys Leu Lys Ser Ile Val Ala Thr Arg 545 550 555 560 Asn Ala Thr Val Val Ile Gly Thr Thr Lys Phe Tyr Gly Gly Trp Asp 565 570 575 Asn Met Leu Lys Asn Leu Met Ala Asp Val Asp Asp Pro Lys Leu Met 580 585 590 Gly Trp Asp Tyr Pro Lys Cys Asp Arg Ala Met Pro Ser Met Ile Arg 595 600 605 Met Leu Ser Ala Met Ile Leu Gly Ser Lys His Val Thr Cys Cys Thr 610 615 620 Ala Ser Asp Lys Phe Tyr Arg Leu Ser Asn Glu Leu Ala Gln Val Leu 625 630 635 640 Thr Glu Val Val Tyr Ser Asn Gly Gly Phe Tyr Phe Lys Pro Gly Gly 645 650 655 Thr Thr Ser Gly Asp Ala Thr Thr Ala Tyr Ala Asn Ser Val Phe Asn 660 665 670 Ile Phe Gln Ala Val Ser Ser Asn Ile Asn Cys Val Leu Ser Val Asn 675 680 685 Ser Ser Asn Cys Asn Asn Phe Asn Val Lys Lys Leu Gln Arg Gln Leu 690 695 700 Tyr Asp Asn Cys Tyr Arg Asn Ser Asn Val Asp Glu Ser Phe Val Asp 705 710 715 720 Asp Phe Tyr Gly Tyr Leu Gln Lys His Phe Ser Met Met Ile Leu Ser 725 730 735 Asp Asp Ser Val Val Cys Tyr Asn Lys Thr Tyr Ala Gly Leu Gly Tyr 740 745 750 Ile Ala Asp Ile Ser Ala Phe Lys Ala Thr Leu Tyr Tyr Gln Asn Gly 755 760 765 Val Phe Met Ser Thr Ala Lys Cys Trp Thr Glu Glu Asp Leu Ser Ile 770 775 780 Gly Pro His Glu Phe Cys Ser Gln His Thr Met Gln Ile Val Asp Glu 785 790 795 800 Asn Gly Lys Tyr Tyr Leu Pro Tyr Pro Asp Pro Ser Arg Ile Ile Ser 805 810 815 Ala Gly Val Phe Val Asp Asp Ile Thr Lys Thr Asp Ala Val Ile Leu 820 825 830 Leu Glu Arg Tyr Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu Ser Lys 835 840 845 His Pro Lys Pro Glu Tyr Arg Lys Val Phe Tyr Ala Leu Leu Asp Trp 850 855 860 Val Lys His Leu Asn Lys Thr Leu Asn Glu Gly Val Leu Glu Ser Phe 865 870 875 880 Ser Val Thr Leu Leu Asp Glu His Glu Ser Lys Phe Trp Asp Glu Ser 885 890 895 Phe Tyr Ala Ser Met Tyr Glu Lys Ser Thr Val Leu Gln Ala Ala Gly 900 905 910 Leu Cys Val Val Cys Gly Ser Gln Thr Val Leu Arg Cys Gly Asp Cys 915 920 925 Leu Arg Arg Pro Met Leu Cys Thr Lys Cys Ala Tyr Asp His Val Phe 930 935 940 Gly Thr Asp His Lys Phe Ile Leu Ala Ile Thr Pro Tyr Val Cys Asn 945 950 955 960 Thr Ser Gly Cys Asn Val Asn Asp Val Thr Lys Leu Tyr Leu Gly Gly 965 970 975 Leu Asn Tyr Tyr Cys Val Asp His Lys Pro His Leu Ser Phe Pro Leu 980 985 990 Cys Ser Ala Gly Asn Val Phe Gly Leu Tyr Lys Ser Ser Ala Leu Gly 995 1000 1005 Ser Met Asp Ile Asp Val Phe Asn Lys Leu Ser Thr Ser Asp Trp 1010 1015 1020 Ser Asp Ile Arg Asp Tyr Lys Leu Ala Asn Asp Ala Lys Glu Ser 1025 1030 1035 Leu Arg Leu Phe Ala Ala Glu Thr Val Lys Ala Lys Glu Glu Ser 1040 1045 1050 Val Lys Ser Ser Tyr Ala Tyr Ala Thr Leu Lys Glu Ile Val Gly 1055 1060 1065 Pro Lys Glu Leu Leu Leu Leu Trp Glu Ser Gly Lys Ala Lys Pro 1070 1075 1080 Pro Leu Asn Arg Asn Ser Val Phe Thr Cys Phe Gln Ile Thr Lys 1085 1090 1095 Asp Ser Lys Phe Gln Val Gly Glu Phe Val Phe Glu Lys Val Asp 1100 1105 1110 Tyr Gly Ser Asp Thr Val Thr Tyr Lys Ser Thr Ala Thr Thr Lys 1115 1120 1125 Leu Val Pro Gly Met Leu Phe Ile Leu Thr Ser His Asn Val Ala 1130 1135 1140 Pro Leu Arg Ala Pro Thr Met Ala Asn Gln Glu Lys Tyr Ser Thr 1145 1150 1155 Ile Tyr Lys Leu His Pro Ser Phe Asn Val Ser Asp Ala Tyr Ala 1160 1165 1170 Asn Leu Val Pro Tyr Tyr Gln Leu Ile Gly Lys Gln Arg Ile Thr 1175 1180 1185 Thr Ile Gln Gly Pro Pro Gly Ser Gly Lys Ser His Cys Ser Ile 1190 1195 1200 Gly Ile Gly Val Tyr Tyr Pro Gly Ala Arg Ile Val Phe Thr Ala 1205 1210 1215 Cys Ser His Ala Ala Val Asp Ser Leu Cys Ala Lys Ala Val Thr 1220 1225 1230 Ala Tyr Ser Val Asp Lys Cys Thr Arg Ile Ile Pro Ala Arg Ala 1235 1240 1245 Arg Val Glu Cys Tyr Ser Gly Phe Lys Pro Asn Asn Asn Ser Ala 1250 1255 1260 Gln Tyr Val Phe Ser Thr Val Asn Ala Leu Pro Glu Val Asn Ala 1265 1270 1275 Asp Ile Val Val Val Asp Glu Val Ser Met Cys Thr Asn Tyr Asp 1280 1285 1290 Leu Ser Val Ile Asn Gln Arg Ile Ser Tyr Lys His Ile Val Tyr 1295 1300 1305 Val Gly Asp Pro Gln Gln Leu Pro Ala Pro Arg Val Leu Ile Ser 1310 1315 1320 Lys Gly Val Met Glu Pro Ile Asp Tyr Asn Val Val Thr Gln Arg 1325 1330 1335 Met Cys Ala Ile Gly Pro Asp Val Phe Leu His Lys Cys Tyr Arg 1340 1345 1350 Cys Pro Ala Glu Ile Val Asn Thr Val Ser Glu Leu Val Tyr Glu 1355 1360 1365 Asn Lys Phe Val Pro Val Lys Glu Ala Ser Lys Gln Cys Phe Lys 1370 1375 1380 Ile Phe Glu Arg Gly Ser Val Gln Val Asp Asn Gly Ser Ser Ile 1385 1390 1395 Asn Arg Arg Gln Leu Asp Val Val Lys Arg Phe Ile His Lys Asn 1400 1405 1410 Ser Thr Trp Ser Lys Ala Val Phe Ile Ser Pro Tyr Asn Ser Gln 1415 1420 1425 Asn Tyr Val Ala Ala Arg Leu Leu Gly Leu Gln Thr Gln Thr Val 1430 1435 1440 Asp Ser Ala Gln Gly Ser Glu Tyr Asp Tyr Val Ile Phe Ala Gln 1445 1450 1455 Thr Ser Asp Thr Ala His Ala Cys Asn Ala Asn Arg Phe Asn Val 1460 1465 1470 Ala Ile Thr Arg Ala Lys Lys Gly Ile Phe Cys Ile Met Ser Asp 1475 1480 1485 Arg Thr Leu Phe Asp Ala Leu Lys Phe Phe Glu Ile Thr Met Thr 1490 1495 1500 Asp Leu Gln Ser Glu Ser Ser Cys Gly Leu Phe Lys Asp Cys Ala 1505 1510 1515 Arg Asn Pro Ile Asp Leu Pro Pro Ser His Ala Thr Thr Tyr Leu 1520 1525 1530 Ser Leu Ser Asp Arg Phe Lys Thr Ser Gly Asp Leu Ala Val Gln 1535 1540 1545 Ile Gly Asn Asn Asn Val Cys Thr Tyr Glu His Val Ile Ser Tyr 1550 1555 1560 Met Gly Phe Arg Phe Asp Val Ser Met Pro Gly Ser His Ser Leu 1565 1570 1575 Phe Cys Thr Arg Asp Phe Ala Met Arg His Val Arg Gly Trp Leu 1580 1585 1590 Gly Met Asp Val Glu Gly Ala His Val Thr Gly Asp Asn Val Gly 1595 1600 1605 Thr Asn Val Pro Leu Gln Val Gly Phe Ser Asn Gly Val Asp Phe 1610 1615 1620 Val Ala Gln Pro Glu Gly Cys Val Leu Thr Asn Thr Gly Ser Val 1625 1630 1635 Val Lys Pro Val Arg Ala Arg Ala Pro Pro Gly Glu Gln Phe Thr 1640 1645 1650 His Ile Val Pro Leu Leu Arg Lys Gly Gln Pro Trp Ser Val Leu 1655 1660 1665 Arg Lys Arg Ile Val Gln Met Ile Ala Asp Phe Leu Ala Gly Ser 1670 1675 1680 Ser Asp Val Leu Val Phe Val Leu Trp Ala Gly Gly Leu Glu Leu 1685 1690 1695 Thr Thr Met Arg Tyr Phe Val Lys Ile Gly Ala Val Lys His Cys 1700 1705 1710 Gln Cys Gly Thr Val Ala Thr Cys Tyr Asn Ser Val Ser Asn Asp 1715 1720 1725 Tyr Cys Cys Phe Lys His Ala Leu Gly Cys Asp Tyr Val Tyr Asn 1730 1735 1740 Pro Tyr Val Ile Asp Ile Gln Gln Trp Gly Tyr Val Gly Ser Leu 1745 1750 1755 Ser Thr Asn His His Ala Ile Cys Asn Val His Arg Asn Glu His 1760 1765 1770 Val Ala Ser Gly Asp Ala Ile Met Thr Arg Cys Leu Ala Val Tyr 1775 1780 1785 Asp Cys Phe Val Lys Asn Val Asp Trp Ser Ile Thr Tyr Pro Met 1790 1795 1800 Ile Ala Asn Glu Asn Ala Ile Asn Lys Gly Gly Arg Thr Val Gln 1805 1810 1815 Ser His Ile Met Arg Ala Ala Ile Lys Leu Tyr Asn Pro Lys Ala 1820 1825 1830 Ile His Asp Ile Gly Asn Pro Lys Gly Ile Arg Cys Ala Val Thr 1835 1840 1845 Asp Ala Lys Trp Tyr Cys Tyr Asp Lys Asn Pro Ile Asn Ser Asn 1850 1855 1860 Val Lys Thr Leu Glu Tyr Asp Tyr Met Thr His Gly Gln Met Asp 1865 1870 1875 Gly Leu Cys Leu Phe Trp Asn Cys Asn Val Asp Met Tyr Pro Glu 1880 1885 1890 Phe Ser Ile Val Cys Arg Phe Asp Thr Arg Thr Arg Ser Thr Leu 1895 1900 1905 Asn Leu Glu Gly Val Asn Gly Gly Ser Leu Tyr Val Asn Asn His 1910 1915 1920 Ala Phe His Thr Pro Ala Tyr Asp Lys Arg Ala Met Ala Lys Leu 1925 1930 1935 Lys Pro Ala Pro Phe Phe Tyr Tyr Asp Asp Gly Ser Cys Glu Val 1940 1945 1950 Val His Asp Gln Val Asn Tyr Val Pro Leu Arg Ala Thr Asn Cys 1955 1960 1965 Ile Thr Lys Cys Asn Ile Gly Gly Ala Val Cys Ser Lys His Ala 1970 1975 1980 Asn Leu Tyr Arg Ala Tyr Val Glu Ser Tyr Asn Ile Phe Thr Gln 1985 1990 1995 Ala Gly Phe Asn Ile Trp Val Pro Thr Thr Phe Asp Cys Tyr Asn 2000 2005 2010 Leu Trp Gln Thr Phe Thr Glu Val Asn Leu Gln Gly Leu Glu Asn 2015 2020 2025 Ile Ala Phe Asn Val Val Asn Lys Gly Ser Phe Val Gly Ala Asp 2030 2035 2040 Gly Glu Leu Pro Val Ala Ile Ser Gly Asp Lys Val Phe Val Arg 2045 2050 2055 Asp Gly Asn Thr Asp Asn Leu Val Phe Val Asn Lys Thr Ser Leu 2060 2065 2070 Pro Thr Asn Ile Ala Phe Glu Leu Phe Ala Lys Arg Lys Val Gly 2075 2080 2085 Leu Thr Pro Pro Leu Ser Ile Leu Lys Asn Leu Gly Val Val Ala 2090 2095 2100 Thr Tyr Lys Phe Val Leu Trp Asp Tyr Glu Ala Glu Arg Pro Leu 2105 2110 2115 Thr Ser Phe Thr Lys Ser Val Cys Gly Tyr Thr Asp Phe Ala Glu 2120 2125 2130 Asp Val Cys Thr Cys Tyr Asp Asn Ser Ile Gln Gly Ser Tyr Glu 2135 2140 2145 Arg Phe Thr Leu Ser Thr Asn Ala Val Leu Phe Ser Ala Thr Ala 2150 2155 2160 Val Lys Thr Gly Gly Lys Ser Leu Pro Ala Ile Lys Leu Asn Phe 2165 2170 2175 Gly Met Leu Asn Gly Asn Ala Ile Ala Thr Val Lys Ser Glu Asp 2180 2185 2190 Gly Asn Ile Lys Asn Ile Asn Trp Phe Val Tyr Val Arg Lys Asp 2195 2200 2205 Gly Lys Pro Val Asp His Tyr Asp Gly Phe Tyr Thr Gln Gly Arg 2210 2215 2220 Asn Leu Gln Asp Phe Leu Pro Arg Ser Thr Met Glu Glu Asp Phe 2225 2230 2235 Leu Asn Met Asp Ile Gly Val Phe Ile Gln Lys Tyr Gly Leu Glu 2240 2245 2250 Asp Phe Asn Phe Glu His Val Val Tyr Gly Asp Val Ser Lys Thr 2255 2260 2265 Thr Leu Gly Gly Leu His Leu Leu Ile Ser Gln Val Arg Leu Ser 2270 2275 2280 Lys Met Gly Ile Leu Lys Ala Glu Glu Phe Val Ala Ala Ser Asp 2285 2290 2295 Ile Thr Leu Lys Cys Cys Thr Val Thr Tyr Leu Asn Asp Pro Ser 2300 2305 2310 Ser Lys Thr Val Cys Thr Tyr Met Asp Leu Leu Leu Asp Asp Phe 2315 2320 2325 Val Ser Val Leu Lys Ser Leu Asp Leu Thr Val Val Ser Lys Val 2330 2335 2340 His Glu Val Ile Ile Asp Asn Lys Pro Trp Arg Trp Met Leu Trp 2345 2350 2355 Cys Lys Asp Asn Ala Val Ala Thr Phe Tyr Pro Gln Leu Gln Ser 2360 2365 2370 Ala Glu Trp Lys Cys Gly Tyr Ser Met Pro Gly Ile Tyr Lys Thr 2375 2380 2385 Gln Arg Met Cys Leu Glu Pro Cys Asn Leu Tyr Asn Tyr Gly Ala 2390 2395 2400 Gly Leu Lys Leu Pro Ser Gly Ile Met Phe Asn Val Val Lys Tyr 2405 2410 2415 Thr Gln Leu Cys Gln Tyr Phe Asn Ser Thr Thr Leu Cys Val Pro 2420 2425 2430 His Asn Met Arg Val Leu His Leu Gly Ala Gly Ser Asp Tyr Gly 2435 2440 2445 Val Ala Pro Gly Thr Ala Val Leu Lys Arg Trp Leu Pro His Asp 2450 2455 2460 Ala Ile Val Val Asp Asn Asp Val Val Asp Tyr Val Ser Asp Ala 2465 2470 2475 Asp Phe Ser Val Thr Gly Asp Cys Ala Thr Val Tyr Leu Glu Asp 2480 2485 2490 Lys Phe Asp Leu Leu Ile Ser Asp Met Tyr Asp Gly Arg Thr Lys 2495 2500 2505 Ala Ile Asp Gly Glu Asn Val Ser Lys Glu Gly Phe Phe Thr Tyr 2510 2515 2520 Ile Asn Gly Phe Ile Cys Glu Lys Leu Ala Ile Gly Gly Ser Ile 2525 2530 2535 Ala Ile Lys Val Thr Glu Tyr Ser Trp Asn Lys Lys Leu Tyr Glu 2540 2545 2550 Leu Val Gln Arg Phe Ser Phe Trp Thr Met Phe Cys Thr Ser Val 2555 2560 2565 Asn Thr Ser Ser Ser Glu Ala Phe Val Val Gly Ile Asn Tyr Leu 2570 2575 2580 Gly Asp Phe Ala Gln Gly Pro Phe Ile Asp Gly Asn Ile Ile His 2585 2590 2595 Ala Asn Tyr Val Phe Trp Arg Asn Ser Thr Val Met Ser Leu Ser 2600 2605 2610 Tyr Asn Ser Val Leu Asp Leu Ser Lys Phe Asn Cys Lys His Lys 2615 2620 2625 Ala Thr Val Val Val Gln Leu Lys Asp Ser Asp Ile Asn Glu Met 2630 2635 2640 Val Leu Ser Leu Val Arg Ser Gly Lys Leu Leu Val Arg Gly Asn 2645 2650 2655 Gly Lys Cys Leu Ser Phe Ser Asn His Leu Val Ser Thr Lys 2660 2665 2670 <210> 92 <211> 448 <212> PRT <213> human coronavirus OC43 <220> <221> MISC_FEATURE <223> ORF N <400> 92 Met Ser Phe Thr Pro Gly Lys Gln Ser Ser Ser Arg Ala Ser Ser Gly 1 5 10 15 Asn Arg Ser Gly Asn Gly Ile Leu Lys Trp Ala Asp Gln Ser Asp Gln 20 25 30 Phe Arg Asn Val Gln Thr Arg Gly Arg Arg Ala Gln Pro Lys Gln Thr 35 40 45 Ala Thr Ser Gln Gln Pro Ser Gly Gly Asn Val Val Pro Tyr Tyr Ser 50 55 60 Trp Phe Ser Gly Ile Thr Gln Phe Gln Lys Gly Lys Glu Phe Glu Phe 65 70 75 80 Val Glu Gly Gln Gly Val Pro Ile Ala Pro Gly Val Pro Ala Thr Glu 85 90 95 Ala Lys Gly Tyr Trp Tyr Arg His Asn Arg Arg Ser Phe Lys Thr Ala 100 105 110 Asp Gly Asn Gln Arg Gln Leu Leu Pro Arg Trp Tyr Phe Tyr Tyr Leu 115 120 125 Gly Thr Gly Pro His Ala Lys Asp Gln Tyr Gly Thr Asp Ile Asp Gly 130 135 140 Val Tyr Trp Val Ala Ser Asn Gln Ala Asp Val Asn Thr Pro Ala Asp 145 150 155 160 Ile Val Asp Arg Asp Pro Ser Ser Asp Glu Ala Ile Pro Thr Arg Phe 165 170 175 Pro Pro Gly Thr Val Leu Pro Gln Gly Tyr Tyr Ile Glu Gly Ser Gly 180 185 190 Arg Ser Ala Pro Asn Ser Arg Ser Thr Ser Arg Thr Ser Ser Arg Ala 195 200 205 Ser Ser Ala Gly Ser Arg Ser Arg Ala Asn Ser Gly Asn Arg Thr Pro 210 215 220 Thr Ser Gly Val Thr Pro Asp Met Ala Asp Gln Ile Ala Ser Leu Val 225 230 235 240 Leu Ala Lys Leu Gly Lys Asp Ala Thr Lys Pro Gln Gln Val Thr Lys 245 250 255 His Thr Ala Lys Glu Val Arg Gln Lys Ile Leu Asn Lys Pro Arg Gln 260 265 270 Lys Arg Ser Pro Asn Lys Gln Cys Thr Val Gln Gln Cys Phe Gly Lys 275 280 285 Arg Gly Pro Asn Gln Asn Phe Gly Gly Gly Glu Met Leu Lys Leu Gly 290 295 300 Thr Ser Asp Pro Gln Phe Pro Ile Leu Ala Glu Leu Ala Pro Thr Ala 305 310 315 320 Gly Ala Phe Phe Phe Gly Ser Arg Leu Glu Leu Ala Lys Val Gln Asn 325 330 335 Leu Ser Gly Asn Pro Asp Glu Pro Gln Lys Asp Val Tyr Glu Leu Arg 340 345 350 Tyr Asn Gly Ala Ile Arg Phe Asp Ser Thr Leu Ser Gly Phe Glu Thr 355 360 365 Ile Met Lys Val Leu Asn Glu Asn Leu Asn Ala Tyr Gln Gln Gln Asp 370 375 380 Gly Met Met Asn Met Ser Pro Lys Pro Gln Arg Gln Arg Gly His Lys 385 390 395 400 Asn Gly Gln Gly Glu Asn Asp Asn Ile Ser Val Ala Val Pro Lys Ser 405 410 415 Arg Val Gln Gln Asn Lys Ser Arg Glu Leu Thr Ala Glu Asp Ile Ser 420 425 430 Leu Leu Lys Lys Met Asp Glu Pro Tyr Thr Glu Asp Thr Ser Glu Ile 435 440 445 <210> 93 <211> 451 <212> PRT <213> murine hepatitis virus <220> <221> MISC_FEATURE <223> ORF N <400> 93 Met Ser Phe Val Pro Gly Gln Glu Asn Ala Gly Ser Arg Ser Ser Ser 1 5 10 15 Gly Asn Arg Ala Gly Asn Gly Ile Leu Lys Lys Thr Thr Trp Ala Asp 20 25 30 Gln Thr Glu Arg Gly Asn Arg Gly Arg Arg Asn His Pro Lys Gln Thr 35 40 45 Ala Thr Thr Gln Pro Asn Ala Gly Ser Val Val Pro His Tyr Ser Trp 50 55 60 Phe Ser Gly Ile Thr Gln Phe Gln Lys Gly Lys Glu Phe Gln Phe Ala 65 70 75 80 Gln Gly Gln Gly Val Pro Ile Ala Ser Gly Ile Pro Ala Ser Glu Gln 85 90 95 Lys Gly Tyr Trp Tyr Arg His Asn Arg Arg Ser Phe Lys Thr Pro Asp 100 105 110 Gly Gln His Lys Gln Leu Leu Pro Arg Trp Tyr Phe Tyr Tyr Leu Gly 115 120 125 Thr Gly Pro His Ala Gly Ala Glu Tyr Gly Asp Asp Ile Glu Gly Val 130 135 140 Val Trp Val Ala Ser Gln Gln Ala Asp Thr Lys Thr Thr Ala Asp Val 145 150 155 160 Val Glu Arg Asp Pro Ser Ser His Glu Ala Ile Pro Thr Arg Phe Ala 165 170 175 Pro Gly Thr Val Leu Pro Gln Gly Phe Tyr Val Glu Gly Ser Gly Arg 180 185 190 Ser Ala Pro Ala Ser Arg Ser Gly Ser Arg Ser Gln Ser Arg Gly Pro 195 200 205 Asn Asn Arg Ala Arg Ser Ser Ser Asn Gln Arg Gln Pro Ala Ser Ala 210 215 220 Val Lys Pro Asp Met Ala Glu Glu Ile Ala Ala Leu Val Leu Ala Lys 225 230 235 240 Leu Gly Lys Asp Ala Gly Gln Pro Lys Gln Val Thr Lys Gln Ser Ala 245 250 255 Lys Glu Val Arg Gln Lys Ile Leu Thr Lys Pro Arg Gln Lys Arg Thr 260 265 270 Pro Asn Lys Gln Cys Pro Val Gln Gln Cys Phe Gly Lys Arg Gly Pro 275 280 285 Asn Gln Asn Phe Gly Gly Ser Glu Met Leu Lys Leu Gly Thr Ser Asp 290 295 300 Pro Gln Phe Pro Ile Leu Ala Glu Leu Ala Pro Thr Pro Ser Ala Phe 305 310 315 320 Phe Phe Gly Ser Lys Leu Glu Leu Val Lys Lys Asn Ser Gly Gly Ala 325 330 335 Asp Glu Pro Thr Lys Asp Val Tyr Glu Leu Gln Tyr Ser Gly Ala Ile 340 345 350 Arg Phe Asp Ser Thr Leu Pro Gly Phe Glu Thr Ile Met Lys Val Leu 355 360 365 Thr Glu Asn Leu Asn Ala Tyr Gln Asp Gln Ala Gly Ser Val Asp Leu 370 375 380 Val Ser Pro Lys Pro Pro Arg Arg Gly Arg Arg Gln Ala Gln Glu Lys 385 390 395 400 Lys Asp Glu Val Asp Asn Val Ser Val Ala Lys Pro Lys Ser Leu Val 405 410 415 Gln Arg Asn Val Ser Arg Glu Leu Thr Pro Glu Asp Arg Ser Leu Leu 420 425 430 Ala Gln Ile Leu Asp Asp Gly Val Val Pro Asp Gly Leu Glu Asp Asp 435 440 445 Ser Asn Val 450 <210> 94 <211> 409 <212> PRT <213> avian infectious bronchitis virus <220> <221> MISC_FEATURE <223> ORF N <400> 94 Met Ala Ser Gly Lys Ala Ala Gly Lys Thr Asp Ala Pro Ala Pro Val 1 5 10 15 Ile Lys Leu Gly Gly Pro Lys Pro Pro Lys Val Gly Ser Ser Gly Asn 20 25 30 Ala Ser Trp Phe Gln Ala Ile Lys Ala Lys Lys Leu Asn Thr Pro Pro 35 40 45 Pro Lys Phe Glu Gly Ser Gly Val Pro Asp Asn Glu Asn Ile Lys Pro 50 55 60 Ser Gln Gln His Gly Tyr Trp Arg Arg Gln Ala Arg Phe Lys Pro Gly 65 70 75 80 Lys Gly Gly Arg Lys Pro Val Pro Asp Ala Trp Tyr Phe Tyr Tyr Thr 85 90 95 Gly Thr Gly Pro Ala Ala Asp Leu Asn Trp Gly Asp Thr Gln Asp Gly 100 105 110 Ile Val Trp Val Ala Ala Lys Gly Ala Asp Thr Lys Ser Arg Ser Asn 115 120 125 Gln Gly Thr Arg Asp Pro Asp Lys Phe Asp Gln Tyr Pro Leu Arg Phe 130 135 140 Ser Asp Gly Gly Pro Asp Gly Asn Phe Arg Trp Asp Phe Ile Pro Leu 145 150 155 160 Asn Arg Gly Arg Ser Gly Arg Ser Thr Ala Ala Ser Ser Ala Ala Ala 165 170 175 Ser Arg Ala Pro Ser Arg Glu Gly Ser Arg Gly Arg Arg Ser Asp Ser 180 185 190 Gly Asp Asp Leu Ile Ala Arg Ala Ala Lys Ile Ile Gln Asp Gln Gln 195 200 205 Lys Lys Gly Ser Arg Ile Thr Lys Ala Lys Ala Asp Glu Met Ala His 210 215 220 Arg Arg Tyr Cys Lys Arg Thr Ile Pro Pro Asn Tyr Arg Val Asp Gln 225 230 235 240 Val Phe Gly Pro Arg Thr Lys Gly Lys Glu Gly Asn Phe Gly Asp Asp 245 250 255 Lys Met Asn Glu Glu Gly Ile Lys Asp Gly Arg Val Thr Ala Met Leu 260 265 270 Asn Leu Val Pro Ser Ser His Ala Cys Leu Phe Gly Ser Arg Val Thr 275 280 285 Pro Lys Leu Gln Leu Asp Gly Leu His Leu Arg Phe Glu Phe Thr Thr 290 295 300 Val Val Pro Cys Asp Asp Pro Gln Phe Asp Asn Tyr Val Lys Ile Cys 305 310 315 320 Asp Gln Cys Val Asp Gly Val Gly Thr Arg Pro Lys Asp Asp Glu Pro 325 330 335 Lys Pro Lys Ser Arg Ser Ser Ser Arg Pro Ala Thr Arg Gly Asn Ser 340 345 350 Pro Ala Pro Arg Gln Gln Arg Pro Lys Lys Glu Lys Lys Leu Lys Lys 355 360 365 Gln Asp Asp Glu Ala Asp Lys Ala Leu Thr Ser Asp Glu Glu Arg Asn 370 375 380 Asn Ala Gln Leu Glu Phe Tyr Asp Glu Pro Lys Val Ile Asn Trp Gly 385 390 395 400 Asp Ala Ala Leu Gly Glu Asn Glu Leu 405 <210> 95 <211> 448 <212> PRT <213> bovine corona virus <220> <221> MISC_FEATURE <223> ORF N <400> 95 Met Ser Phe Thr Pro Gly Lys Gln Ser Ser Ser Arg Ala Ser Phe Gly 1 5 10 15 Asn Arg Ser Gly Asn Gly Ile Leu Lys Trp Ala Asp Gln Ser Asp Gln 20 25 30 Ser Arg Asn Val Gln Thr Arg Gly Arg Arg Ala Gln Pro Lys Gln Thr 35 40 45 Ala Thr Ser Gln Leu Pro Ser Gly Gly Asn Val Val Pro Tyr Tyr Ser 50 55 60 Trp Phe Ser Gly Ile Thr Gln Phe Gln Lys Gly Lys Glu Phe Glu Phe 65 70 75 80 Ala Glu Gly Gln Gly Val Pro Ile Ala Pro Gly Val Pro Ala Thr Glu 85 90 95 Ala Lys Gly Tyr Trp Tyr Arg His Asn Arg Arg Ser Phe Lys Thr Ala 100 105 110 Asp Gly Asn Gln Arg Gln Leu Leu Pro Arg Trp Tyr Phe Tyr Tyr Leu 115 120 125 Gly Thr Gly Pro His Ala Lys Asp Gln Tyr Gly Thr Asp Ile Asp Gly 130 135 140 Val Phe Trp Val Ala Ser Asn Gln Ala Asp Val Asn Thr Pro Ala Asp 145 150 155 160 Ile Leu Asp Arg Asp Pro Ser Ser Asp Glu Ala Ile Pro Thr Arg Phe 165 170 175 Pro Pro Gly Thr Val Leu Pro Gln Gly Tyr Tyr Ile Glu Gly Ser Gly 180 185 190 Arg Ser Ala Pro Asn Ser Arg Ser Thr Ser Arg Ala Ser Ser Arg Ala 195 200 205 Ser Ser Ala Gly Ser Arg Ser Arg Ala Asn Ser Gly Asn Arg Thr Pro 210 215 220 Thr Ser Gly Val Thr Pro Asp Met Ala Asp Gln Ile Ala Ser Leu Val 225 230 235 240 Leu Ala Lys Leu Gly Lys Asp Ala Thr Lys Pro Gln Gln Val Thr Lys 245 250 255 Gln Thr Ala Lys Glu Ile Arg Gln Lys Ile Leu Asn Lys Pro Arg Gln 260 265 270 Lys Arg Ser Pro Asn Lys Gln Cys Thr Val Gln Gln Cys Phe Gly Lys 275 280 285 Arg Gly Pro Asn Gln Asn Phe Gly Gly Gly Glu Met Leu Lys Leu Gly 290 295 300 Thr Ser Asp Pro Gln Phe Pro Ile Leu Ala Glu Leu Ala Pro Thr Ala 305 310 315 320 Gly Ala Phe Phe Phe Gly Ser Arg Leu Glu Leu Ala Lys Val Gln Asn 325 330 335 Leu Ser Gly Asn Leu Asp Glu Pro Gln Lys Asp Val Tyr Glu Leu Arg 340 345 350 Tyr Asn Gly Ala Ile Arg Phe Asp Ser Thr Leu Ser Gly Phe Glu Thr 355 360 365 Ile Met Lys Val Leu Asn Glu Asn Leu Asn Ala Tyr Gln Gln Gln Asp 370 375 380 Gly Met Met Asn Met Ser Pro Lys Pro Gln Arg Gln Arg Gly Gln Lys 385 390 395 400 Asn Gly Gln Gly Glu Asn Asp Asn Ile Ser Val Ala Ala Pro Lys Ser 405 410 415 Arg Val Gln Gln Asn Lys Ser Arg Glu Leu Thr Ala Glu Asp Ile Ser 420 425 430 Leu Leu Lys Lys Met Asp Glu Pro Tyr Thr Glu Asp Thr Ser Glu Ile 435 440 445 <210> 96 <211> 449 <212> PRT <213> porcine haemagglutinating encaphalomyelitis virus <220> <221> MISC_FEATURE <223> ORF N <400> 96 Met Ser Phe Thr Pro Gly Lys Gln Ser Ser Ser Arg Ala Ser Ser Gly 1 5 10 15 Asn Arg Ser Gly Asn Gly Ile Leu Lys Trp Ala Asp Gln Ser Asp Gln 20 25 30 Ser Arg Asn Val Gln Thr Arg Gly Arg Arg Val Gln Ser Lys Gln Thr 35 40 45 Ala Thr Ser Gln Gln Pro Ser Gly Gly Thr Val Val Pro Tyr Tyr Ser 50 55 60 Trp Phe Ser Gly Ile Thr Gln Phe Gln Lys Gly Lys Glu Phe Glu Phe 65 70 75 80 Ala Glu Gly Gln Gly Val Pro Ile Ala Pro Gly Val Pro Ser Thr Glu 85 90 95 Ala Lys Gly Tyr Trp Tyr Arg His Asn Arg Arg Ser Phe Lys Thr Ala 100 105 110 Asp Gly Asn Gln Arg Gln Leu Leu Pro Arg Trp Tyr Phe Tyr Tyr Leu 115 120 125 Gly Thr Gly Pro His Ala Lys Asp Gln Tyr Gly Thr Asp Ile Asp Gly 130 135 140 Val Phe Trp Val Ala Ser Asn Gln Ala Asp Ile Asn Thr Pro Ala Asp 145 150 155 160 Ile Val Asp Arg Asp Pro Ser Ser Asp Glu Ala Ile Pro Thr Arg Phe 165 170 175 Pro Pro Gly Thr Val Leu Pro Gln Gly Tyr Tyr Ile Glu Gly Ser Gly 180 185 190 Arg Ser Ala Pro Asn Ser Arg Ser Thr Ser Arg Ala Pro Asn Arg Ala 195 200 205 Pro Ser Ala Gly Ser Arg Ser Arg Ala Asn Ser Gly Asn Arg Thr Ser 210 215 220 Thr Pro Gly Val Thr Pro Asp Met Ala Asp Gln Ile Ala Ser Leu Val 225 230 235 240 Leu Ala Lys Leu Gly Lys Asp Ala Thr Lys Pro Gln Gln Val Thr Lys 245 250 255 Gln Thr Ala Lys Glu Val Arg Gln Lys Ile Leu Asn Lys Pro Arg Gln 260 265 270 Lys Arg Ser Pro Asn Lys Gln Cys Thr Val Gln Gln Cys Phe Gly Lys 275 280 285 Arg Gly Pro Asn Gln Asn Phe Gly Gly Gly Glu Met Leu Lys Leu Gly 290 295 300 Thr Ser Asp Pro Gln Phe Pro Ile Leu Ala Glu Leu Ala Pro Thr Ala 305 310 315 320 Gly Ala Phe Phe Phe Gly Ser Arg Leu Glu Leu Ala Lys Val Gln Asn 325 330 335 Leu Ser Gly Asn Pro Asp Glu Pro Gln Lys Asp Val Tyr Glu Leu Arg 340 345 350 Tyr Asn Gly Ala Ile Arg Phe Asp Ser Thr Leu Ser Gly Phe Glu Thr 355 360 365 Ile Met Lys Val Leu Asn Gln Asn Leu Asn Ala Tyr Gln His Gln Glu 370 375 380 Asp Gly Met Met Asn Ile Ser Pro Lys Pro Gln Arg Gln Arg Gly Gln 385 390 395 400 Lys Asn Gly Gln Val Glu Asn Asp Asn Val Ser Val Ala Ala Pro Lys 405 410 415 Ser Arg Val Gln Gln Asn Lys Ser Arg Glu Leu Thr Ala Glu Asp Ile 420 425 430 Ser Leu Leu Lys Lys Met Asp Glu Pro Tyr Thr Glu Asp Thr Ser Glu 435 440 445 Ile <210> 97 <211> 422 <212> PRT <213> human SARS virus <220> <221> MISC_FEATURE <223> ORF N <400> 97 Met Ser Asp Asn Gly Pro Gln Ser Asn Gln Arg Ser Ala Pro Arg Ile 1 5 10 15 Thr Phe Gly Gly Pro Thr Asp Ser Thr Asp Asn Asn Gln Asn Gly Gly 20 25 30 Arg Asn Gly Ala Arg Pro Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn 35 40 45 Asn Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Glu 50 55 60 Leu Arg Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Gly 65 70 75 80 Pro Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Val Arg 85 90 95 Gly Gly Asp Gly Lys Met Lys Glu Leu Ser Pro Arg Trp Tyr Phe Tyr 100 105 110 Tyr Leu Gly Thr Gly Pro Glu Ala Ser Leu Pro Tyr Gly Ala Asn Lys 115 120 125 Glu Gly Ile Val Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys 130 135 140 Asp His Ile Gly Thr Arg Asn Pro Asn Asn Asn Ala Ala Thr Val Leu 145 150 155 160 Gln Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly 165 170 175 Ser Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg 180 185 190 Gly Asn Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Asn Ser Pro 195 200 205 Ala Arg Met Ala Ser Gly Gly Gly Glu Thr Ala Leu Ala Leu Leu Leu 210 215 220 Leu Asp Arg Leu Asn Gln Leu Glu Ser Lys Val Ser Gly Lys Gly Gln 225 230 235 240 Gln Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser 245 250 255 Lys Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Gln Tyr Asn Val Thr 260 265 270 Gln Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly 275 280 285 Asp Gln Asp Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln 290 295 300 Ile Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg 305 310 315 320 Ile Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr His Gly 325 330 335 Ala Ile Lys Leu Asp Asp Lys Asp Pro Gln Phe Lys Asp Asn Val Ile 340 345 350 Leu Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu 355 360 365 Pro Lys Lys Asp Lys Lys Lys Lys Thr Asp Glu Ala Gln Pro Leu Pro 370 375 380 Gln Arg Gln Lys Lys Gln Pro Thr Val Thr Leu Leu Pro Ala Ala Asp 385 390 395 400 Met Asp Asp Phe Ser Arg Gln Leu Gln Asn Ser Met Ser Gly Ala Ser 405 410 415 Ala Asp Ser Thr Gln Ala 420

Claims (27)

1. 도 1의 서열 또는 그것의 동족체를 포함하는 분리된 본질적으로 포유동물의 양성-센스 단일가닥 RNA 바이러스(EMCR-CoV).
2. 바이러스의 핵산 서열을 결정하고, 그것을 최대 가능도 트리가 100 부트스트랩과 3 점블을 이용하여 생성되는 계통트리 분석에서 시험하고, 그리고 그것이 PEDV(돼지 유행성 설사 바이러스), HCoV-229E(인간 코로나바이러스 229E), PRCoV(돼지 호흡기 코로나바이러스), TGEV(전염성 위장염 바이러스), CaCoV(개 코로나바이러스) 및 FeCoV(고양이 코로나바이러스)의 바이러스 분리물에 상응하는 것보다 도 1에 나타낸 바와 같은 서열을 갖는 바이러스 분리물에 더욱 밀접히 계통적으로 상응한다는 것을 확인함에 의해, 그것에 계통적으로 상응한다고 동정될 수 있고 그리고 코로나바이러스에 속하는 분리된 양성-센스 단일 가닥 RNA 바이러스(EMCR-CoV).
3. 제1항 또는 제2항에 있어서, 상기 핵산 서열은 상기 바이러스의 바이러스 단백질을 암호화하는 개방형해독틀(ORF)을 포함하는 바이러스.
4. 제3항에 있어서, 상기 개방형해독틀은 바이러스 리플리카제, 핵 캡시드 단백질, 매트릭스 단백질 및 스파이크 단백질을 암호화하는 ORF들의 군으로부터 선택되 는 바이러스.
5. 제1항 내지 제4항 중 어느 한 항에 있어서, 비정형 폐렴의 인간으로부터 분리될 수 있는 바이러스.
6. 제1항 내지 제5항 중 어느 한 항에 따른 바이러스로부터 얻을 수 있는 분리된 또는 재조합 핵산 또는 그것의 EMCR-CoV 바이러스-특이 기능적 단편.
7. 제6항에 따른 핵산을 포함하는 벡터.
8. 제6항에 따른 핵산 또는 제7항에 따른 벡터를 포함하는 숙주세포.
9. 제6항에 따른 핵산에 의해 암호화된 분리된 또는 재조합 단백질성 분자 또는 그것의 EMCR-CoV 바이러스-특이 기능적 단편.
10. 제 9항에 따른 단백질성 분자 또는 그것의 EMCR-CoV 바이러스-특이 기능적 단편을 포함하는 항원.
11. 제10항에 따른 항원에 대해 특이적으로 지향된 항체.
12. 바이러스 분리물 또는 그것의 성분을 제11항에 따른 항체와 반응시키는 것을 포함하는, 바이러스 분리물이 EMCR-CoC 바이러스임을 동정하는 방법.
13. 바이러스 분리물 또는 그것의 성분을 제6항에 따른 핵산과 반응시키는 것을포함하는, 바이러스 분리물이 EMCR-CoV 바이러스임을 동정하는 방법.
14. 포유동물의 샘플에서 바이러스 분리물 또는 그것의 성분의 존재를, 상기 샘플과 제6항에 따른 핵산 또는 제11항에 따른 항체를 반응시키는 것에 의해 결정하는 것을 포함하는, 포유동물의 EMCR-CoV 감염을 바이러스학적으로 진단하는 방법.
15. 포유동물의 샘플에서 EMCR-CoV 바이러스 또는 그것의 성분에 대해 특이적으로 지향된 항체의 존재를, 상기 샘플과 제9항에 따른 단백질성 분자 또는 그것의 단편 또는 제 10항에 따른 항원을 반응시키는 것에 의해 결정하는 것을 포함하는, 포유동물의 EMCR-CoV 감염을 혈청학적으로 진단하는 방법.
16. 제1항 내지 제5항 중 어느 한 항에 따른 바이러스, 제 6항에 따른 핵산, 제9항에 따른 단백질성 분자 또는 그것의 단편, 제 10항에 따른 항원 및/또는 제11항에 따른 항체를 포함하는 EMCR-CoV 감염을 진단하기 위한 진단 키트.
17. 약제학적 조성물의 생산을 위한, 제1항 내지 제5항 중 어느 한 항에 따른 바 이러스, 제 6항에 따른 핵산, 제한 7항에 따른 벡터, 제8항에 따른 숙주 세포, 제9항에 따른 단백질성 분자 또는 그것의 단편, 제 10항에 따른 항원 또는 제11항에 따른 항체의 용도.
18. 제17항에 있어서, EMCR-CoV 바이러스 감염의 치료 및 예방용 약제학적 조성물의 생산을 위한 용도.
19. 제17항 또는 제18항에 있어서, 비정형 폐렴의 치료 및 예방용 약제학적 조성물의 생산을 위한 용도.
20. 제1항 내지 제5항 중 어느 한 항에 따른 바이러스, 제6항에 따른 핵산, 제7항에 따른 벡터, 제8항에 따른 숙주세포, 제9항에 따른 단백질성 분자 또는 그것의 단편, 제10항에 따른 항원 또는 제11항에 따른 항체를 포함하는 약제학적 조성물.
21. 개체에게 제20항에 따른 약제학적 조성물을 제공하는 것을 포함하는 EMCR-CoV 바이러스 감염의 치료 및 예방방법.
22. 개체에게 제20항에 따른 약제학적 조성물을 제공하는 것을 포함하는 비정형 폐렴의 치료 및 예방방법.
23. 도 1에 나타낸 바와 같이 표시된 서열 또는 그것의 동족체를 포함하는 RNA 서열에 의해 암호화되는 바이러스 리플리카제.
24. 도 1에 나타낸 바와 같이 표시된 아미노산 서열 또는 그것의 단편을 포함하는 바이러스 스파이크 단백질.
25. 도 1에 나타낸 바와 같이 표시된 서열 또는 그것의 동족체를 포함하는 RNA 서열에 의해 암호화된 바이러스 핵 캡시드 단백질.
26. 도 1에 나타낸 바와 같이 표시된 서열 또는 그것의 단편을 포함하는 RNA 서열에 의해 암호화된 바이러스 nsp 3 또는 엔벨롭프 단백질.
27. 도 1에 나타낸 바와 같은 별개의 바이러스 단백질들을 암호화하는 하나 이상의 서열 또는 스트린전트 조건에서 이들 서열 중 어느 것과 혼성화할 수 있는 핵산서열을 포함하는 핵산서열.

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