KR20060109311A - Insecticide for controlling flies - Google Patents

Abstract

An insecticidal composition for controlling flies is provided to improve insecticidal activity, so that the excellent insecticidal effect is accomplished by using a smaller amount of the composition. The insecticidal composition for controlling flies comprises 1-(2-chloro-5-thiazolyl)methyl-3-methyl-2-nitroguanidine and N-(2-ethylhexyl)-5-norbornene-2,3-dicarboximide(MGK264), wherein the weight ratio of 1-(2-chloro-5-thiazolyl)methyl-3-methyl-2-nitroguanidine to N-(2-ethylhexyl)-5-norbornene-2,3-dicarboximide(MGK264) is 1:1 to 1:50; and the composition is used for controlling flies in a stall.

Description

Paris Control Agents {INSECTICIDE FOR CONTROLLING FLIES}

[Patent Document 1] Japanese Patent Application Laid-Open No. 3-157308

[Patent Document 2] Japanese Unexamined Patent Publication No. 2001-302408

Technical Field

The present invention relates to a fly control agent and a fly control method.

Prior art

Formula

1- (2-chloro-5-thiazolyl) methyl-3-methyl-2-nitroguanidine [1- (2-chloro-5-thiazolyl) methyl-3-methyl-2-nitroguanidine] (cloti It is known that the pesticide which uses anidine clothianidin) has a control effect against fly insect pests, such as a housefly which inhabits or flies in a barn or a cage (patent documents 1 and 2).

However, the effect is not to exhibit a sufficiently satisfactory performance, but to provide a new control agent.

An object of this invention is to provide the new control agent which has the outstanding control effect with respect to a fly.

According to the present invention, clothianidine and N- (2-ethylhexyl) -5-norbornene-2,3-dicarboxyimide [N- (2-ethylhexyl) -5-norbornene-2,3-dicarboximide The fly control agent containing (MGK264) as an active ingredient can sufficiently control the fly and exhibit synergistic synergism even when the compound is used alone, even if the control effect is not sufficient. The application amount of each compound can be reduced.

The present invention also provides a method of controlling flies by applying clotianidine and MGK264 to a place of flies.

Clotianidine can be manufactured by the method of patent document 1, etc., and can also use a commercial item as it is. MGK264 is a compound known as a synergist for pyrethroid insecticides, and can be produced by a conventional method, but it is convenient to use a commercially available product as it is.

The fly control agent of the present invention has a control effect against various pests, but particularly has a synergistically superior control effect with respect to flies compared to the case where clothianidine and MGK264 are used alone. In the present invention, the term "fly" means a Braohycera pest, and as a specific example, a housefly (Musca domestica), a baby housefly (Fannia canicularis), a king fly (Muscina stabulans), and a flyfly (Stomoxys calcitrans) , Muscidae pests such as Haematonia irritans; Horsefly pest (Oestridae); Gastroophilidae pests; Calliphordea pests such as Calliphora late, Aldrichina grahami, and Lucilia caesar; Sarcophagidae pests; Glossinidae pests; Dong-ae et al. (Stratiomyidae) pests; (Tabanidae) pests such as Tabanus trigonus and so on; Phoridae pests such as Megagaselia spiracularis; Syrddae pests; Piophilidae Pests; And Dromylidae pests and Drosophilidae pests.

The fly control agent of the present invention has a particularly excellent synergy in the control of houseflies and pests and black flies and pests, and has excellent effects in the control of flies inhabiting or flying in barns, for example in barns, pigs, cages and stalls. To indicate.

In the fly control agent of the present invention, the mixing ratio of clothianidine and MGK264 is usually from 1: 1 to 1: 100, preferably from 1: 1 to 1:50, particularly preferably from 1: 1 to 1 by weight. 1: 10 ratio.

Although the fly control agent of this invention may consist only of clotianidine and MGK264, it usually contains a solid carrier, a liquid carrier, and / or a gaseous carrier. In addition, surfactants and auxiliary agents for other preparations may be added if necessary, and liquids and powders such as emulsions, flocculating agents, emulsions, spot-on preparations, pore-on preparations, shampoo preparations and suspensions, etc. , Hydrating agents, granules, paste-like preparations, microencapsulation preparations, foaming agents, aerosol preparations, carbonic acid gas preparations, heated oxidizers (such as incense), smokers, fumigants, tablets, sheet preparations, resins What is formulated as a formulation may be sufficient and at the time of application, a suitable formulation form is selected suitably.

When the fly control agent of the present invention is formulated, the amount of clothianidine and MGK264 contained in the formulation may be appropriately changed depending on the form of the preparation, but as a total amount of clotianidine and MGK264 (active ingredient amount), It is about 0.01 to 90 weight%.

As a carrier used at the time of formulation, and the adjuvant for preparations, the following are mentioned, for example.

As the solid carrier, for example, clay, kaolin, talc, bentonite, sericite, quartz, sulfur, activated carbon, calcium carbonate, diatomaceous earth ( Natural or synthetic, such as diatomaceous earth, pumice, calcite, calcite, dolomite, muscovite, silica, alumina, vermiculite, perlite, etc. Minerals, sawdust, corn cobs, coconut shells, fine grains of tobacco stems, gelatin, petrolatum, vaseline, methylcellulose, lanolin and lard. .

Examples of the liquid carrier include aromatic or aliphatic hydrocarbons such as xylene, toluene, alkylnaphthalene, phenylxylyl ethane, kerosene, diesel, hexane, cyclohexane, liquid paraffin, chlorobenzene, dichloroethane, dichloromethane and trichloro. Halogenated hydrocarbons such as roethane, methanol, ethanol, isopropyl alcohol, butanol, hexanol, benzyl alcohol, alcohols such as ethylene glycol, diethyl ether, ethylene glycol dimethyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl Ethers such as ether, propylene glycol monomethyl ether, tetrahydrofuran, 1,4-dioxane, esters such as ethyl acetate and butyl acetate, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone and cyclohexanone, aceto Sulfoxides such as nitriles such as nitrile and isobutylonitrile, alkylene carbonates such as propylene carbonate and dimethyl sulfoxide, Acid amides such as N, N-dimethylformamide, N, N-dimethylacetamide, N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone, N-octyl-2-pyrrolidone and the like Plant essential oils such as pyrrolidone, 1,3-dimethyl-2-imidazolidinone, soybean oil, cottonseed oil, plant oils such as orange oil, hyssop oil and lemon oil; and water.

Examples of the gaseous carrier include propane gas, butane gas, chlorofluorocarbon, liquefied petroleum gas (LPG), dimethyl ether, and carbon dioxide gas.

Moreover, as a base material of a resin preparation, a vinyl chloride type polymer, a polyurethane, etc. are mentioned, for example, A phthalic acid ester (dimethyl phthalate, dioctyl phthalate phthalate, etc.) and adipic acid ester are needed for these base materials as needed. And plasticizers such as stearic acid are added. As a manufacturing method of a resin formulation, after klotyanidin and MGK264 are knead | mixed in the base material of the said resin formulation using a conventional kneading apparatus, it is a method of manufacturing by conventional molding methods, such as injection molding, extrusion molding, press molding, etc. Can be mentioned. The molded article thus obtained may be used as the fly control agent of the present invention as it is, but the molded article may be used as an animal collar and an animal eartack through steps such as molding and cutting.

Moreover, as an adjuvant for formulation, For example, Nonionic emulsifiers, such as polyoxyethylene fatty acid ester and polyoxyethylene fatty acid alcohol ether, Ionic emulsifiers, such as alkyl sulfonate, alkyl sulfate, and aryl sulfonate, lignin sulfonate, etc. Fixing agents, such as a dispersing agent, carboxymethylcellulose, gum arabic, polyvinyl alcohol, and polyvinylacetate, a coloring agent, such as iron oxide, titanium oxide, Prussian blue, alizarin dye, azo dye, and phthalocyanine dye, etc. are mentioned.

The present control agent can also be used in combination with other active ingredients such as insecticides, nematicides, acaricides, pest repellents, fungicides, herbicides and plant growth regulators.

Such active ingredients are, for example, permethrin, phenothrin, resmethrin, allethrin, pyrethrin, prallethrin, cife Cyphenothrin, cyfluthrin, fenvalerate, fenpropathrin, empprothrin, biphenthrin, transfluthrin, 2 , 3,5,6-tetrafluoro-4-methoxymethylbenzyl 1R-trans-3- (2-methyl-1-propenyl) -2,2-dimethylcyclopropanecarboxylate [2,3,5 , 6-tetrafluoro-4-mothoxymethylbenzyl 1R-trans-3- (2-methyl-1-propenyl-2,2-dimethylcyclopropane carboxylate], 2,3,5,6-tetrafluoro-4-methoxymethylbenzyl 1R -Trans-3- (1-propenyl (E / Z = 1/8))-2,2-dimethylcyclopropanecarboxylate [2,3,5,6-tetrafluoro-4-methoxymethylbenzyl 1R-trans-3 -(1-propenyl (E / Z = 1/8))-2,2-dimethylcyclo propanecarboxylate], 2,3,5,6-tetraplop Oro-4-methylbenzyl 1R-trans-3- (1-propenyl (E / Z = 1/8))-2,2-dimethylcyclopropanecarboxylate [2,3,5,6-tetrafluoro-4 pyrethroid compounds such as -methylbenzyl 1R-trans-3- (1-propenyl (E / Z = 1/8))-2,2-dimethylcyclopropane carboxylate], dichlorvos, tetrachlorvinphos ), Organophosphorus compounds such as fenthion, chlorpyrifos, fenitrothion, diazinon, propoxyur, carbaryl, methoxadione ( carmate compounds such as metoxadiazone, fenobucarb, chitin formation inhibitors such as lufenuron, chlorfluazuron, hexaflumuron, and cyromazine development inhibitors such as synthesis inhibitors, pyriproxyfen, metoprene, hydroprene, phenoxycarb, etc. internal parasitic remedies such as ile hormone mimics, N-phenylpyrrazole-based compounds, milbectin, abamectin, ivermectin, selamectin, N , N-diethyl-m-toluamide (N, N-dimethyl-m-toluamide), limonene (limonene), linalol (linalol), citroneral, menthol, menthol And pest repellents such as hinokitiol, geraniol, and eucalyptol.

The fly control agent of the present invention is usually used by applying directly to a fly and / or a place of flies (houses, barns, animals, soil, etc.). The application amount is generally 0.011 to 100 mg / m 3 as the effective ingredient amount when the fly control agent of the present invention is spargically sprayed in a house or in a barn, and is 0.01 as the effective ingredient amount when it is treated on a flat surface such as the bottom surface. To 1000 mg / m 2. Emulsifiers, hydrating agents, flooring agents, etc. are usually applied by diluting with water so as to have an active ingredient concentration of 0.01 to 10000 ppm, and applying them. The emulsion, aerosol, smoke agent, and the like are usually applied as they are.

In addition, when the fly control agent of this invention is applied to animal bodies, such as pets, such as a dog and a cat, and domestic animals, such as a cow, a pig, and a chicken, 0.01-500 mg / kg is normally applied as an active ingredient amount.

Example

Hereinafter, although an Example, such as a formulation example and a test example, shows this invention concretely, this invention is not limited to these.

First, a formulation example is shown.

(Example 1)

2 parts by weight of clothianidine and 7 parts by weight of MGK264 are dissolved in 37.5 parts by weight of xylene and 37.5 parts by weight of dimethylformamide, and 10 parts by weight of polyoxyethylene styrylphenyl ether and 6 parts by weight of dodecylbenzenesulfonate Add and stir well to obtain an emulsion.

(Example 2)

1.5 parts by weight of clotianidine, 3 parts by weight of MGK264, 1 part by weight of synthetic hydrated silica fine powder, 1 part by weight of Dorires B (manufactured by Sankyo Co., Ltd., flocculant) and 7 parts by weight of clay in a mortar and pestle After mixing, the mixture is stirred and mixed with a juice mixer. 86.5 weight part of cut clays are added to the obtained mixture, and it fully stirs and mixes, and obtains a powder.

(Example 3)

To 5 parts by weight of clotianidine and 35 parts by weight of MGK264, 5 parts by weight of sorbol 5060 (registered trademark of Toho Chemical Industry Co., Ltd., surfactant) was added and mixed well, 32 parts by weight of fine powder of synthetic silicon oxide, 300 mesh 23 parts by weight of diatomaceous earth are added and mixed by a juice mixer to obtain a wetting agent.

(Example 4)

To 10 parts by weight of clothianidine, 5 parts by weight of d-resmethrin, and 30 parts by weight of MGK264, 5 parts by weight of solpol 5060 (registered trademark of Toho Chemical Industries, Ltd., surfactant) was added, mixed well, and a synthetic function 30 parts by weight of fine silicon oxide powder and 20 parts by weight of 300 mesh diatomaceous earth are added and mixed by a juice mixer to obtain a hydrating agent.

(Example 5)

1 part by weight of clothianidine, 2 parts by weight of MGK264, 5 parts by weight of synthetic hydrous silicon oxide powder, 5 parts by weight of sodium dodecylbenzenesulfonate, 30 parts by weight of bentonite and 57 parts by weight of clay, and are then stirred and mixed well, followed by An appropriate amount of water is added to the mixture of the mixture, further stirred, granulated with a granulator, and air dried to obtain granules.

(Example 6)

0.1 part by weight of clothianidine and 0.4 part by weight of MGK264 are dissolved in 12 parts by weight of propylene carbonate, the solution is filled into an aerosol bottle, and ethanol is added to make the total part 20 parts by weight. A valve part is attached to this aerosol container, and 80 weight part of dimethyl ethers are pressurized and filled through this valve part, and an aerosol is obtained by attaching an actuator.

Next, a test example shows that the present invention control agent has a control effect on flies.

(Test Example 1)

Acetone dilutions containing Clotianidine, MGK264, and a mixture of Clotianidine and MGK264, each formulated to a predetermined throughput, were respectively treated with pyrethroid drug resistant housefly (miyakonojo colony; Miyazaki in 1933). A housefly is collected from a barn in Miyakonojo, prefecture, and later raised in a laboratory in the lab, see App. Ent. Zool. 1988, Vol. 23, No. 5, pages 144-149. 0.5 µL of the back plate was treated and lethality after 1 day was examined. Ten animals of each group were given to the test, and the average value of the test result of 3 replicates is shown in Table 1.

Trial offer control Throughput (μg / horse) Lethality (%) Clotianidine One 0 2 0 MGK264 10 0 Clotianidine + MGK264 (fly control agent of the present invention) 1 + 5 60 2 + 2 40 2 + 6 60 2 + 10 90

(Reference Test Example 1)

The acetone dilution solution containing clotianidine, MGK264, and a mixture of clotianidine and MGK264, which had been adjusted to a predetermined throughput, was placed in the middle of the rear part of the colony larvae (about 3 mg in weight). Was treated with 0.3 µl, and the lethality after 7 days was examined. Ten animals of each group were used for the test, and the average value of the test result of 2 replicates is shown in Table 2.

Trial offer control Throughput (μg / horse) Lethality (%) Clotianidine 0.1 55 MGK264 0.5 0 Clotianidine + MGK264 (fly control agent of the present invention) 0.1 + 0.5 50

(Reference Test Example 2)

Diethylene glycol monoethyl ether dilutions containing clotianidine, MGK264, and a mixture of clotianidine and MGK264, prepared at a predetermined throughput, were added to adult cockroach adults (5 males and 5 females), respectively. Sprayed from the front of the ml, and after 30 seconds of spraying, all the cockroaches were transferred to a clean container and checked for mortality 3 days later. Table 3 shows the average of the three replicate test results.

Trial offer control Throughput (μg / horse) Lethality (%) Clotianidine 0.0025 83 MGK264 0.025 0 Clotianidine + MGK264 (fly control agent of the present invention) 0.0025 + 0.025 77

As evident from the comparison between Table 1 (control effects against flies) and Table 2 (control effects against mosquitoes) and Table 3 (control effects against cockroaches), the inventive control agents are markedly synergistic, especially against flies. Exert

The fly control agent of this invention exhibits remarkable synergism, and therefore shows the excellent control effect with respect to various flies by application of a low dose.

Claims (6)

1- (2-chloro-5-thiazolyl) methyl-3-methyl-2-nitroguanidine and N- (2-ethylhexyl) -5-norbornene-2,3-dicarboxyimide as active ingredients The fly control agent containing it. The method of claim 1, The weight ratio of 1- (2-chloro-5-thiazolyl) methyl-3-methyl-2-nitroguanidine and N- (2-ethylhexyl) -5-norbornene-2,3-dicarboxyimide A fly control agent of 1: 1 to 1:50. The method according to claim 1 or 2, Paris control to control flies in barns. 1- (2-chloro-5-thiazolyl) methyl-3-methyl-2-nitroguanidine, N- (2-ethylhexyl) -5-norbornene-2,3-dicarboxyimide in Paris or Paris It is applied to a place of habitat, The control method of Paris. The method of claim 3, wherein The weight ratio of 1- (2-chloro-5-thiazolyl) methyl-3-methyl-2-nitroguanidine and N- (2-ethylhexyl) -5-norbornene-2,3-dicarboxyimide The control method of the fly in the range of 1: 1-1: 50. The method according to claim 4 or 5, Application of 1- (2-chloro-5-thiazolyl) methyl-3-methyl-2-nitroguanidine and N- (2-ethylhexyl) -5-norbornene-2,3-dicarboxyimide in pens How to control Paris.