JPH1160413A - Insecticide - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an insecticide capable of more fast-actingly and more surely controlling parasites on the outsides of animals by including (E)-N<1> -[(6-chloro-3- pyridyl)methyl]N<2> -cyano-N<1> -methylacetamide and pyriproxyfen. SOLUTION: This insecticide contains (E)-N<1> -[(6-chloro-3-pyridyl)methy1]N<2> cyano-N"-methylacetamidine and pyriproxyfen preferably in a weight ratio of 1:1 to 100:1, more preferably 2:1 to 20:1. The insecticide is especially preferable as a control agent for parasites such as Aphaniptera insect pests, Acarina insect pests, Anoplura insect pests and Diptera insect pests on the outsides of animals such as domestic animals, e.g. cattle and sheep, and pets such as dogs and cats, and is applied at a dose of generally about 0.002-0.2 g as the insecticidal ingredient per kg of animal body weight.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to an insecticide, and more particularly, to an insecticide suitable for controlling ectoparasites in animals and a method for administering the insecticide parenterally or orally to domestic animals or pets. The present invention relates to a method for controlling ectoparasites in animals.

[0002]

2. Description of the Related Art Conventionally, as an insecticidal component for controlling ectoparasites that damage livestock such as cattle and sheep and pets such as dogs and cats, organophosphorus compounds, carbamate compounds, Pyrethroid compounds, insect growth regulators and the like have been used. However, their effects on ectoparasites, such as a weak lethal effect or a lack of rapid efficacy, are not necessarily sufficient.

[0003]

Therefore, there is a need for the development of an insecticide that can more quickly and more reliably control animal ectoparasites and a control method using the same.

[0004]

Under such circumstances, the present inventors have made intensive studies to develop an insecticide which is particularly effective against ectoparasites of animals and which has a high control effect.
^{(E) -N 1 - [(} 6- chloro-3-pyridyl) methyl] N ² - cyano -N ¹ - insecticide containing methyl acetamidine and pyriproxyfen, provided that they are compatible for such purposes Heading, the present invention has been completed. That is, the present invention relates to an insecticide containing (E) -N ¹ -[(6-chloro-3-pyridyl) methyl] N ² -cyano-N ¹ -methylacetamidine and pyriproxyfen as insecticidal components (hereinafter referred to as insecticides). And an insect ectoparasite control agent containing these compounds as an insecticidal component, and a method for controlling ectoparasites in animals using the insecticide.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION In the present insecticide, (E) -N ¹
-[(6-Chloro-3-pyridyl) methyl] N ² -cyano-N ¹ -methylacetamidine and pyriproxyfen are preferably mixed in a weight ratio of 1: 1 to 100: 1, more preferably, The range is from 2: 1 to 20: 1.
This insecticide is particularly suitable as an agent for controlling ectoparasites that inflict livestock such as cattle and sheep and pets such as dogs and cats,
Direct application to animal ectoparasites can exert their controlling effect, and particularly to effectively control these ectoparasites by parenterally or orally administering to host animals. Becomes possible.

The animal ectoparasites to be controlled by the insecticide include, for example, cat flea (Ctenocephalides feli)
s), flea insects such as dog flea (Ctenocephalides canis), Haemaphyxalis longicorni
s), mites pests such as ox tick (Boophilus microplus), louse pests such as bovine lice (Haematopinus eurysternus) and sheep lice (Damalinia ovis), house fly (Musca hervei), and house fly (Musca bezzi)
i), Haematobia irritans, Simulium iwatens, Culicoides oxy
stoma), Bullflies (Tabanus chrysurus), Culex pipiens
(Culex pipiens), Aedes albopictus (Aedes albopictus)
And the like. Pests other than these animal ectoparasites (for example, housefly (Musca domestic)
It is also effective for extermination of a) etc.). Examples of the target animal include livestock such as cows, sheep, goats and chickens, dogs, cats, mice, rats, hamsters, squirrels,
This includes pets such as rabbits, ferrets, ducks, and pigeons, and experimental animals.

The application rate of the insecticide to these animals can vary depending on the preparation used, but generally, the amount of the insecticide is 0.002 g per kg of animal body weight.
About 0.2 g. The present insecticide is usually prepared by mixing the above-mentioned insecticide component with a solid carrier or a liquid carrier and, if necessary, adding a surfactant or other co-solvent for formulation to prepare an emulsion,
A composition used as an emulsion, spot-on, pour-on, shampoo, aerosol, foam aerosol, powder, tablet, injection, etc., or formulated into a resin such as a collar, medallion or ear tag. Used as The content of the insecticidal component in these preparations varies depending on the type of the preparation and the method of application, but the total amount of both compounds is 0.00
The content is preferably 1 to 40 parts by weight, more preferably 0.0
1 to 20 parts by weight.

[0008] Examples of solid carriers used in the formulation include clays (kaolin clay, diatomaceous earth, bentonite, acid clay, etc.), synthetic hydrous silicon oxide, talcs, ceramics, and other inorganic minerals (sericite, quartz). , Sulfur, activated carbon, calcium carbonate, hydrated silica, etc.) and fine powders and granules such as chemical fertilizers (ammonium sulphate, phosphorous ammonium, ammonium nitrate, urea, salt ammonium, etc.). -Ketones (acetone, methyl ethyl ketone, etc.), aromatic hydrocarbons (toluene, etc.), aliphatic hydrocarbons (hexane, kerosene, paraffin, petroleum benzine, etc.), Esters (ethyl acetate, butyl acetate, etc.), ethers (tetrahydrofuran, dioxane, etc.), halogenated hydrocarbons (dichloroethane, trichloroethane) Emissions, carbon tetrachloride and the like) and the like. If necessary, propane gas, butane gas,
Formulation can also be made by adding a propellant such as liquefied petroleum gas, chlorofluorocarbon gas, dimethyl ether or carbon dioxide gas. Examples of the surfactant used include alkyl sulfates, alkyl aryl sulfonates, alkyl aryl ethers and polyoxyethylenates thereof, polyethylene glycol ethers, polyhydric alcohol esters, and the like. Sugar alcohol derivatives and the like can be mentioned. Other auxiliary solvents for preparations such as fixing agents and dispersants include, for example, casein, gelatin, saccharides (starch, gum arabic, cellulose derivatives, alginic acid, etc.), lignin derivatives, bentonite, synthetic water-soluble polymers (polyvinyl alcohol). -Polyvinylpyrrolidone, polyacrylic acids, etc.).
PAP (acidic isopropyl phosphate), BHT
(2,6-di-tert-butyl-4-methylpheno-
), BHA (2-tert-butyl-4-methoxyphenol and 3-tert-butyl-4-methoxyphenol)
), Vegetable oils, mineral oils, fatty acids, fatty acid esters, and other stabilizers are also used as auxiliary solvents for preparations. Examples of the base material of the resin agent include, for example, vinyl chloride-based polymers and polyurethanes. These base materials include phthalate esters (dimethyl phthalate, dioctyl phthalate, etc.), adipate esters, A plasticizer such as stearic acid is added. In the production of the resin agent, the insecticidal component is kneaded in the base material using a usual kneading apparatus, and then molded by injection molding, extrusion molding, press molding or the like. The thus formed insecticidal composition can be further processed into an animal collar, a medallion, or an ear tag through appropriate processes such as molding and cutting.

The present insecticide may further contain other insecticides, such as other insect growth regulators, pyrethroids, organophosphorus compounds, carbamates. Compounds, repellents and the like. Other insect growth regulators include mesoprene, phenoxycarb,
Hydroprene, diflubenzuron, chlorofluazuron, triflumuron, flufenoxuron, hexaflumuron, cyromazine, lufenuron and the like. Examples of the pyrethroid-based compound include fenpropathrin, permethrin, alesulin, d-allethrin, praletrin, cyphenothrin, phenothrin, resmethrin, empentrin, fenvalerate, cyhalothrin, cyfluthrin, etofenprox, tralomethrin, esbiosrin, transfluthrin, Teraresulin, 1-ethynyl-2-fluoro-2-pentenyl
3- (2,2-dichlorovinyl) -2,2-dimethylcyclopropanecarboxylate and the like. As the organic phosphorus compound, for example, fenitrothion, naled,
Examples include fenthion, cyanophos, chlorpyrifos, diazinon, carclofos, salicion, tetrachlorvinphos, dichlorvos and the like. Examples of the carbamate compounds include BPMC, propoxur, methoxadiazone, carbaryl and the like. As repellents, for example, karan-3,4-diol, N, N-diethyl-m-triamide (Deet), limonene, linalo-
And citronellal, menthol, mentone, hinokitiol, geraniol, eucalyptol and the like. Further, an allyldiazol-based compound, 2-methoxycarbonyl-4-chloro-trifluoromethanesulfonanilide, or the like can be used in combination.

The present insecticide may optionally contain an antioxidant such as butylhydroxyanisole, dibutylhydroxytoluene, tocophenol, γ-oryzanol, etc.
(2,3,3,3-tetrachloropropyl) ether,
N- (2-ethylhexyl) bicyclo [2,2,1] hept-5-ene-2,3-dicarboximide, α-
[2- (2-butoxyethoxy) ethoxy] -4,5-
Synergists such as methylenedioxy-2-propyltoluene,
You may contain a stabilizer etc.

[0011]

Next, the present invention will be described in more detail with reference to examples. (Formulation Example 1) (E) -N ¹ -[(6-chloro-3-
Pyridyl) methyl] N ² -cyano-N ¹ -methylacetamidine (generic name: acetamiprid) 0.1 part by weight and pyriproxyfen 0.01 part by weight are dissolved in ethanol to make the whole 35 parts by weight, and an aerosol container Fill. Next, after attaching a valve to the aerosol container, 65 parts by weight of LPG (propellant) is filled under pressure through the valve portion to obtain an aerosol. Test Example 1 Acetamiprid 0.02 g and pyriproxyfen 0.005 g were dissolved in ethanol to make 20 ml.
The solution was further diluted with ethanol to obtain a diluted solution having a predetermined concentration. 2.0 ml of the diluted solution was uniformly sprayed on a mouse body surface having a living weight of about 30 g from a distance of 20 cm using a glass atomizer. The mouse was dried with a dryer for 1 minute, and then fixed with a wire mesh. The mouse is placed in a glass bottle, followed by a cat flea non-blood sucking adult 20.
I put my head. Twenty-four hours later, the flea mortality was examined. Each triplicate was performed. The same test was performed for mice treated with only ethanol as a non-treatment group. Table 1 shows the test results.

[Table 1]

Effects of the Invention ^{(E) -N 1 - [(} 6- chloro-3-pyridyl) methyl] N ² - cyano -N ¹ - insecticide of the present invention containing the methyl acetamidine and pyriproxyfen as pesticidally component Shows a high control effect on pests ectoparasitic to animals, especially when treated on animals.

Claims (3)

[Claims] (1) It is characterized by containing (E) -N ¹ -[(6-chloro-3-pyridyl) methyl] N ² -cyano-N ¹ -methylacetamidine and pyriproxyfen as insecticidal components. Insecticide. 2. The composition according to claim 1, wherein (E) -N ¹ -[(6-chloro-3-pyridyl) methyl] N ² -cyano-N ¹ -methylacetamidine and pyriproxyfen are contained as insecticidal components. Animal ectoparasite control agent. 3. An insecticide containing (E) -N ¹ -[(6-chloro-3-pyridyl) methyl] N ² -cyano-N ¹ -methylacetamidine and pyriproxyfen is administered to a host animal without the use of an insecticide. A method for controlling ectoparasites in animals, which is administered orally or orally.