KR20060096147A - 신규한 트리터펜 유도체, 그 제조방법 및 용도 - Google Patents

신규한 트리터펜 유도체, 그 제조방법 및 용도 Download PDF

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Publication number
KR20060096147A
KR20060096147A KR1020067008088A KR20067008088A KR20060096147A KR 20060096147 A KR20060096147 A KR 20060096147A KR 1020067008088 A KR1020067008088 A KR 1020067008088A KR 20067008088 A KR20067008088 A KR 20067008088A KR 20060096147 A KR20060096147 A KR 20060096147A
Authority
KR
South Korea
Prior art keywords
compound
methyl
dimethylsuccinyl
hydrogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020067008088A
Other languages
English (en)
Korean (ko)
Inventor
칼 티. 와일드
게리 엔. 로빈손
마크 에쉬톤
러쎌 토마스
Original Assignee
파나코스 파마슈티칼즈, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 파나코스 파마슈티칼즈, 인크. filed Critical 파나코스 파마슈티칼즈, 인크.
Publication of KR20060096147A publication Critical patent/KR20060096147A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/40—Succinic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/42—Glutaric acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/52—Ortho- or ortho- and peri-condensed systems containing five condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020067008088A 2003-09-26 2004-09-27 신규한 트리터펜 유도체, 그 제조방법 및 용도 Withdrawn KR20060096147A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50589903P 2003-09-26 2003-09-26
US60/505,899 2003-09-26
US55935804P 2004-04-05 2004-04-05
US60/559,358 2004-04-05

Publications (1)

Publication Number Publication Date
KR20060096147A true KR20060096147A (ko) 2006-09-07

Family

ID=34396277

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067008088A Withdrawn KR20060096147A (ko) 2003-09-26 2004-09-27 신규한 트리터펜 유도체, 그 제조방법 및 용도

Country Status (10)

Country Link
US (1) US20050148561A1 (enExample)
EP (1) EP1675866A1 (enExample)
JP (1) JP2007506761A (enExample)
KR (1) KR20060096147A (enExample)
AU (1) AU2004276307A1 (enExample)
BR (1) BRPI0415023A (enExample)
CA (1) CA2540160A1 (enExample)
IL (1) IL174317A0 (enExample)
NO (1) NO20061792L (enExample)
WO (1) WO2005030790A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06010592A (es) * 2004-03-17 2007-06-12 Panacos Pharmaceuticals Inc Sales farmaceuticas de acido 3-o-(3',3'-dimetilsuccinil) betulinico.
JP2008535923A (ja) * 2005-04-12 2008-09-04 パナコス ファーマシューティカルズ インコーポレーティッド ３−ｏ−（３’，３’−ジメチルスクシニル）ベツリン酸ジ−ｎ−メチル−ｄ−グルカミンの多形
US20090149429A1 (en) * 2005-06-22 2009-06-11 Myriad Genetics, Incorporated Antiviral compounds
GB0604899D0 (en) * 2006-03-10 2006-04-19 York Pharma Plc Derivatives of 18-glycyrrhetinic acid
US20080039428A1 (en) * 2006-06-29 2008-02-14 Panacos Pharmaceuticals, Inc. Antiretroviral combination therapy
US20110144069A1 (en) * 2006-10-16 2011-06-16 Myriad Genetics, Incorporated Compounds for treating viral infections
AR063546A1 (es) 2006-11-03 2009-01-28 Panacos Pharmaceuticals Inc DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH.
WO2008146305A2 (en) * 2007-06-01 2008-12-04 Council Of Scientific & Industrial Research A pharmaceutical composition having virucidal and spermicidal activity
KR100941595B1 (ko) * 2008-06-05 2010-02-11 주식회사 알앤엘바이오 바이러스 억제제로서 유용한 트리테르페노이드계 화합물
CN102532245B (zh) * 2011-12-31 2013-05-15 中国人民解放军第三军医大学 一种熊果酸衍生物及其制备方法
CN110121334A (zh) * 2017-01-05 2019-08-13 加州大学董事会 三萜类化合物的避孕药用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1415601A (en) * 1973-03-14 1975-11-26 Biorex Laboratories Ltd Dihydrobetulinic acid derivatives
AU2001294953A1 (en) * 2000-09-29 2002-04-08 Regents Of The University Of Minnesota Triterpenes having fungicidal activity against yeast

Also Published As

Publication number Publication date
EP1675866A1 (en) 2006-07-05
NO20061792L (no) 2006-06-14
BRPI0415023A (pt) 2006-11-07
US20050148561A1 (en) 2005-07-07
AU2004276307A1 (en) 2005-04-07
IL174317A0 (en) 2006-08-01
CA2540160A1 (en) 2005-04-07
JP2007506761A (ja) 2007-03-22
WO2005030790A1 (en) 2005-04-07

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20060426

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid