JP2007506761A - 新規なトリテルペン誘導体、その製法および使用 - Google Patents
新規なトリテルペン誘導体、その製法および使用 Download PDFInfo
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- JP2007506761A JP2007506761A JP2006528207A JP2006528207A JP2007506761A JP 2007506761 A JP2007506761 A JP 2007506761A JP 2006528207 A JP2006528207 A JP 2006528207A JP 2006528207 A JP2006528207 A JP 2006528207A JP 2007506761 A JP2007506761 A JP 2007506761A
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- Prior art keywords
- compound
- methyl
- dimethylsuccinyl
- hydrogen
- formula
- Prior art date
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- 238000000034 method Methods 0.000 claims description 37
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 35
- -1 carboxyalkoxymethyl Chemical group 0.000 claims description 33
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 28
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- YFNGWGVTFYSJHE-UHFFFAOYSA-K trisodium;phosphonoformate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O YFNGWGVTFYSJHE-UHFFFAOYSA-K 0.000 description 1
- 229940111527 trizivir Drugs 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 150000003675 ursolic acids Chemical class 0.000 description 1
- 229940023080 viracept Drugs 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 229940098802 viramune Drugs 0.000 description 1
- 229940100050 virazole Drugs 0.000 description 1
- 229940032699 vistide Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 235000020138 yakult Nutrition 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
- 229940087450 zerit Drugs 0.000 description 1
- 229940052255 ziagen Drugs 0.000 description 1
- 229940107931 zovirax Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/40—Succinic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/42—Glutaric acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/52—Ortho- or ortho- and peri-condensed systems containing five condensed rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50589903P | 2003-09-26 | 2003-09-26 | |
| US55935804P | 2004-04-05 | 2004-04-05 | |
| PCT/US2004/031370 WO2005030790A1 (en) | 2003-09-26 | 2004-09-27 | Novel triterpene derivatives, preparation thereof and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007506761A true JP2007506761A (ja) | 2007-03-22 |
| JP2007506761A5 JP2007506761A5 (enExample) | 2007-11-15 |
Family
ID=34396277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006528207A Withdrawn JP2007506761A (ja) | 2003-09-26 | 2004-09-27 | 新規なトリテルペン誘導体、その製法および使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050148561A1 (enExample) |
| EP (1) | EP1675866A1 (enExample) |
| JP (1) | JP2007506761A (enExample) |
| KR (1) | KR20060096147A (enExample) |
| AU (1) | AU2004276307A1 (enExample) |
| BR (1) | BRPI0415023A (enExample) |
| CA (1) | CA2540160A1 (enExample) |
| IL (1) | IL174317A0 (enExample) |
| NO (1) | NO20061792L (enExample) |
| WO (1) | WO2005030790A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06010592A (es) * | 2004-03-17 | 2007-06-12 | Panacos Pharmaceuticals Inc | Sales farmaceuticas de acido 3-o-(3',3'-dimetilsuccinil) betulinico. |
| JP2008535923A (ja) * | 2005-04-12 | 2008-09-04 | パナコス ファーマシューティカルズ インコーポレーティッド | ３−ｏ−（３’，３’−ジメチルスクシニル）ベツリン酸ジ−ｎ−メチル−ｄ−グルカミンの多形 |
| US20090149429A1 (en) * | 2005-06-22 | 2009-06-11 | Myriad Genetics, Incorporated | Antiviral compounds |
| GB0604899D0 (en) * | 2006-03-10 | 2006-04-19 | York Pharma Plc | Derivatives of 18-glycyrrhetinic acid |
| US20080039428A1 (en) * | 2006-06-29 | 2008-02-14 | Panacos Pharmaceuticals, Inc. | Antiretroviral combination therapy |
| US20110144069A1 (en) * | 2006-10-16 | 2011-06-16 | Myriad Genetics, Incorporated | Compounds for treating viral infections |
| AR063546A1 (es) | 2006-11-03 | 2009-01-28 | Panacos Pharmaceuticals Inc | DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH. |
| WO2008146305A2 (en) * | 2007-06-01 | 2008-12-04 | Council Of Scientific & Industrial Research | A pharmaceutical composition having virucidal and spermicidal activity |
| KR100941595B1 (ko) * | 2008-06-05 | 2010-02-11 | 주식회사 알앤엘바이오 | 바이러스 억제제로서 유용한 트리테르페노이드계 화합물 |
| CN102532245B (zh) * | 2011-12-31 | 2013-05-15 | 中国人民解放军第三军医大学 | 一种熊果酸衍生物及其制备方法 |
| CN110121334A (zh) * | 2017-01-05 | 2019-08-13 | 加州大学董事会 | 三萜类化合物的避孕药用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1415601A (en) * | 1973-03-14 | 1975-11-26 | Biorex Laboratories Ltd | Dihydrobetulinic acid derivatives |
| AU2001294953A1 (en) * | 2000-09-29 | 2002-04-08 | Regents Of The University Of Minnesota | Triterpenes having fungicidal activity against yeast |
-
2004
- 2004-09-27 BR BRPI0415023-6A patent/BRPI0415023A/pt not_active IP Right Cessation
- 2004-09-27 KR KR1020067008088A patent/KR20060096147A/ko not_active Withdrawn
- 2004-09-27 JP JP2006528207A patent/JP2007506761A/ja not_active Withdrawn
- 2004-09-27 AU AU2004276307A patent/AU2004276307A1/en not_active Abandoned
- 2004-09-27 WO PCT/US2004/031370 patent/WO2005030790A1/en not_active Ceased
- 2004-09-27 EP EP04784972A patent/EP1675866A1/en active Pending
- 2004-09-27 CA CA002540160A patent/CA2540160A1/en not_active Abandoned
- 2004-09-27 US US10/949,875 patent/US20050148561A1/en not_active Abandoned
-
2006
- 2006-03-14 IL IL174317A patent/IL174317A0/en unknown
- 2006-04-24 NO NO20061792A patent/NO20061792L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1675866A1 (en) | 2006-07-05 |
| NO20061792L (no) | 2006-06-14 |
| BRPI0415023A (pt) | 2006-11-07 |
| KR20060096147A (ko) | 2006-09-07 |
| US20050148561A1 (en) | 2005-07-07 |
| AU2004276307A1 (en) | 2005-04-07 |
| IL174317A0 (en) | 2006-08-01 |
| CA2540160A1 (en) | 2005-04-07 |
| WO2005030790A1 (en) | 2005-04-07 |
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| A521 | Request for written amendment filed |
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