CA2540160A1 - Novel triterpene derivatives, preparation thereof and use thereof - Google Patents

Novel triterpene derivatives, preparation thereof and use thereof Download PDF

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Publication number
CA2540160A1
CA2540160A1 CA002540160A CA2540160A CA2540160A1 CA 2540160 A1 CA2540160 A1 CA 2540160A1 CA 002540160 A CA002540160 A CA 002540160A CA 2540160 A CA2540160 A CA 2540160A CA 2540160 A1 CA2540160 A1 CA 2540160A1
Authority
CA
Canada
Prior art keywords
compound
methyl
dimethylsuccinyl
hydrogen
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002540160A
Other languages
English (en)
French (fr)
Inventor
Carl T. Wild
Gary N. Robinson
Mark Ashton
Russell Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2540160A1 publication Critical patent/CA2540160A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/40—Succinic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/42—Glutaric acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/52—Ortho- or ortho- and peri-condensed systems containing five condensed rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002540160A 2003-09-26 2004-09-27 Novel triterpene derivatives, preparation thereof and use thereof Abandoned CA2540160A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US50589903P 2003-09-26 2003-09-26
US60/505,899 2003-09-26
US55935804P 2004-04-05 2004-04-05
US60/559,358 2004-04-05
PCT/US2004/031370 WO2005030790A1 (en) 2003-09-26 2004-09-27 Novel triterpene derivatives, preparation thereof and use thereof

Publications (1)

Publication Number Publication Date
CA2540160A1 true CA2540160A1 (en) 2005-04-07

Family

ID=34396277

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002540160A Abandoned CA2540160A1 (en) 2003-09-26 2004-09-27 Novel triterpene derivatives, preparation thereof and use thereof

Country Status (10)

Country Link
US (1) US20050148561A1 (enExample)
EP (1) EP1675866A1 (enExample)
JP (1) JP2007506761A (enExample)
KR (1) KR20060096147A (enExample)
AU (1) AU2004276307A1 (enExample)
BR (1) BRPI0415023A (enExample)
CA (1) CA2540160A1 (enExample)
IL (1) IL174317A0 (enExample)
NO (1) NO20061792L (enExample)
WO (1) WO2005030790A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1730163A4 (en) * 2004-03-17 2009-12-30 Panacos Pharmaceuticals Inc Pharmaceutical salts of 3-O- (3,3-dimethylsuccinyl) betulinic acid
BRPI0610668A2 (pt) * 2005-04-12 2010-07-13 Panacos Pharmaceuticals Inc polimorfas de di-n-metil-d-glucamina do ácido 3-o-(3',3'-dimetilsuccinil) betulìnico
EP1893629A4 (en) * 2005-06-22 2008-12-17 Myriad Genetics Inc ANTIVIRAL CONNECTIONS
GB0604899D0 (en) * 2006-03-10 2006-04-19 York Pharma Plc Derivatives of 18-glycyrrhetinic acid
US20080039428A1 (en) * 2006-06-29 2008-02-14 Panacos Pharmaceuticals, Inc. Antiretroviral combination therapy
WO2008115281A2 (en) * 2006-10-16 2008-09-25 Myriad Genetics, Inc. Compounds for treating viral infections
WO2008057420A2 (en) 2006-11-03 2008-05-15 Panacos Pharmaceuticals, Inc. Extended triterpene derivatives
WO2008146305A2 (en) * 2007-06-01 2008-12-04 Council Of Scientific & Industrial Research A pharmaceutical composition having virucidal and spermicidal activity
KR100941595B1 (ko) * 2008-06-05 2010-02-11 주식회사 알앤엘바이오 바이러스 억제제로서 유용한 트리테르페노이드계 화합물
CN102532245B (zh) * 2011-12-31 2013-05-15 中国人民解放军第三军医大学 一种熊果酸衍生物及其制备方法
WO2018128956A1 (en) 2017-01-05 2018-07-12 Regents Of The University Of California Contraceptive use of triterpenoids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1415601A (en) * 1973-03-14 1975-11-26 Biorex Laboratories Ltd Dihydrobetulinic acid derivatives
JP2004509972A (ja) * 2000-09-29 2004-04-02 リージェンツ　オブ　ザ　ユニバーシティ　オブ　ミネソタ 酵母に対する殺真菌活性を有するトリテルペン

Also Published As

Publication number Publication date
BRPI0415023A (pt) 2006-11-07
JP2007506761A (ja) 2007-03-22
IL174317A0 (en) 2006-08-01
EP1675866A1 (en) 2006-07-05
WO2005030790A1 (en) 2005-04-07
AU2004276307A1 (en) 2005-04-07
US20050148561A1 (en) 2005-07-07
NO20061792L (no) 2006-06-14
KR20060096147A (ko) 2006-09-07

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Legal Events

Date Code Title Description
FZDE Discontinued