KR20050120787A - 2-프로필리덴-19-노르-비타민 ｄ 화합물 - Google Patents
2-프로필리덴-19-노르-비타민 ｄ 화합물 Download PDFInfo
- Publication number
- KR20050120787A KR20050120787A KR1020057019087A KR20057019087A KR20050120787A KR 20050120787 A KR20050120787 A KR 20050120787A KR 1020057019087 A KR1020057019087 A KR 1020057019087A KR 20057019087 A KR20057019087 A KR 20057019087A KR 20050120787 A KR20050120787 A KR 20050120787A
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- KR
- South Korea
- Prior art keywords
- compound
- hydroxy
- group
- hydrogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000000203 mixture Substances 0.000 claims description 74
- 229910052739 hydrogen Inorganic materials 0.000 claims description 66
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 65
- 239000001257 hydrogen Substances 0.000 claims description 63
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 19
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- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 16
- 125000004043 oxo group Chemical group O=* 0.000 claims description 16
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- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
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- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 description 1
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- QHJWOSHIGFDANE-UHFFFAOYSA-N prop-2-enylphosphane Chemical compound PCC=C QHJWOSHIGFDANE-UHFFFAOYSA-N 0.000 description 1
- 125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
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- 235000011006 sodium potassium tartrate Nutrition 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
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- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
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- 238000007070 tosylation reaction Methods 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46195803P | 2003-04-10 | 2003-04-10 | |
| US60/461,958 | 2003-04-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20050120787A true KR20050120787A (ko) | 2005-12-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057019087A Abandoned KR20050120787A (ko) | 2003-04-10 | 2004-04-09 | 2-프로필리덴-19-노르-비타민 ｄ 화합물 |
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| Country | Link |
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| US (3) | US7241747B2 (enExample) |
| EP (1) | EP1613588B1 (enExample) |
| JP (1) | JP5005340B2 (enExample) |
| KR (1) | KR20050120787A (enExample) |
| CN (2) | CN101293894B (enExample) |
| AT (1) | ATE556999T1 (enExample) |
| AU (1) | AU2004230948A1 (enExample) |
| BR (1) | BRPI0409194A (enExample) |
| CA (1) | CA2516233C (enExample) |
| MX (1) | MXPA05009336A (enExample) |
| MY (1) | MY146504A (enExample) |
| NZ (1) | NZ542674A (enExample) |
| WO (1) | WO2004092118A2 (enExample) |
| ZA (1) | ZA200506204B (enExample) |
Families Citing this family (14)
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| NZ542674A (en) * | 2003-04-10 | 2009-03-31 | Wisconsin Alumni Res Found | 2-Propylidene-19-nor-vitamin D compounds |
| US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
| CA2597624C (en) * | 2005-02-11 | 2012-08-14 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20s-24s)-1.alpha.,25-dihydroxyvitamin-d2 |
| US7511030B2 (en) * | 2005-02-11 | 2009-03-31 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20S-24epi)-1α,25-dihydroxyvitamin D2 |
| US8114393B2 (en) | 2005-09-14 | 2012-02-14 | Wisconsin Alumni Research Foundation | Methods and compositions for phosphate binding |
| US20090281340A1 (en) * | 2006-04-05 | 2009-11-12 | Deluca Hector F | 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and treatment thereof |
| WO2007117563A2 (en) * | 2006-04-05 | 2007-10-18 | Wisconsin Alumni Research Foundation | 1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and use thereof |
| NZ570814A (en) * | 2006-04-06 | 2011-11-25 | Wisconsin Alumni Res Found | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
| NZ570815A (en) * | 2006-04-06 | 2012-01-12 | Wisconsin Alumni Res Found | 19-nor-vitamin D analogs with 1,2,or 3,2 heterocyclic ring |
| ATE523487T1 (de) * | 2006-04-06 | 2011-09-15 | Wisconsin Alumni Res Found | 2-methylen-1-alpha-dihydroxy-19,21-dinor-vitami - d3-analoga und ihre anwendung |
| US8575136B2 (en) * | 2006-04-06 | 2013-11-05 | Wisconsin Alumni Research Foundation | 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| EP2021321B1 (en) * | 2006-04-06 | 2012-06-20 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 and uses thereof |
| JP2009532460A (ja) | 2006-04-06 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−置換−１α，２５−ジヒドロキシ−１９，２６，２７−トリノルビタミンＤ類縁体およびその使用 |
| MX2008012674A (es) * | 2006-04-10 | 2008-10-15 | Wisconsin Alumni Res Found | Compuestos de 1 a-hidroxi-2-(3'-hidroxipropiliden)-19-nor-vitamina d con una cadena lateral 1,1-dimetilpropilo. |
Family Cites Families (27)
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| GB2114570B (en) | 1981-11-02 | 1985-08-07 | Res Inst Medicine Chem | Chemical compounds |
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| GB8904154D0 (en) | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| NZ232734A (en) | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
| US5246925A (en) * | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
| ATE173401T1 (de) | 1990-09-07 | 1998-12-15 | Wisconsin Alumni Res Found | Neue verwendung von 1-alpha-hydroxylierten-19-nor-vitamin-d-verbind ngen zur behandlung von psoriasis |
| AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP3213092B2 (ja) * | 1991-11-01 | 2001-09-25 | 中外製薬株式会社 | ２β位に置換基を有するビタミンＤ誘導体 |
| JP2898882B2 (ja) * | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| US5565589A (en) * | 1993-11-03 | 1996-10-15 | Wisconsin Alumni Research Foundation | 17-formyl-5,6-trans-vitamin D compounds |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| WO1996001811A1 (en) * | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
| AU4235696A (en) * | 1994-11-21 | 1996-06-17 | Wisconsin Alumni Research Foundation | 18,19-dinor-vitamin d compounds |
| US5877168A (en) * | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
| IL118156A (en) * | 1995-05-09 | 2001-08-26 | Duphar Int Res | Vitamin d compounds, their preparation and pharmaceutical compositions containing them |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| GB9915839D0 (en) * | 1999-07-06 | 1999-09-08 | Textron Automotive U K | Valve assembly for vehicle washing system |
| EP1524264A3 (en) * | 2000-05-31 | 2010-01-20 | Wisconsin Alumni Research Foundation | 2-ethylidene-19-nor-vitamin D compounds |
| US6806262B2 (en) * | 2000-05-31 | 2004-10-19 | Wisconsin Alumni Research Foundation | 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| NZ542674A (en) * | 2003-04-10 | 2009-03-31 | Wisconsin Alumni Res Found | 2-Propylidene-19-nor-vitamin D compounds |
| WO2005051396A2 (en) * | 2003-11-25 | 2005-06-09 | Deltanoid Pharmaceuticals, Inc. | Methods for reducing body fat using vitamin d compounds |
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- 2004-04-09 KR KR1020057019087A patent/KR20050120787A/ko not_active Abandoned
- 2004-04-09 AT AT04749961T patent/ATE556999T1/de active
- 2004-04-09 US US10/544,163 patent/US20060293291A1/en not_active Abandoned
- 2004-04-09 EP EP04749961A patent/EP1613588B1/en not_active Expired - Lifetime
- 2004-04-09 CN CN2008101302056A patent/CN101293894B/zh not_active Expired - Fee Related
- 2004-04-09 CN CNB2004800096206A patent/CN100534981C/zh not_active Expired - Fee Related
- 2004-04-09 JP JP2006509883A patent/JP5005340B2/ja not_active Expired - Fee Related
- 2004-10-14 MY MYPI20044250A patent/MY146504A/en unknown
-
2007
- 2007-05-17 US US11/750,172 patent/US7531527B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2516233C (en) | 2011-09-20 |
| NZ542674A (en) | 2009-03-31 |
| HK1086817A1 (zh) | 2006-09-29 |
| EP1613588A2 (en) | 2006-01-11 |
| US7241747B2 (en) | 2007-07-10 |
| ATE556999T1 (de) | 2012-05-15 |
| WO2004092118A2 (en) | 2004-10-28 |
| JP5005340B2 (ja) | 2012-08-22 |
| CA2516233A1 (en) | 2004-10-28 |
| US20040229851A1 (en) | 2004-11-18 |
| MY146504A (en) | 2012-08-15 |
| ZA200506204B (en) | 2006-10-25 |
| CN100534981C (zh) | 2009-09-02 |
| US20070213546A1 (en) | 2007-09-13 |
| BRPI0409194A (pt) | 2006-04-11 |
| EP1613588B1 (en) | 2012-05-09 |
| US7531527B2 (en) | 2009-05-12 |
| AU2004230948A1 (en) | 2004-10-28 |
| CN101293894A (zh) | 2008-10-29 |
| CN1771226A (zh) | 2006-05-10 |
| MXPA05009336A (es) | 2005-11-04 |
| CN101293894B (zh) | 2011-04-06 |
| US20060293291A1 (en) | 2006-12-28 |
| WO2004092118A3 (en) | 2005-01-27 |
| JP2006523239A (ja) | 2006-10-12 |
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