KR20050118709A - 중간체 생성물로서의피롤리딘-１,２-디카르복실산-１-(페닐(-아미드))-２-(페닐(-아미드)) 유도체 및１-(페닐카르바모일)-피롤리딘-2-카르복실산 유도체의 제조방법 - Google Patents
중간체 생성물로서의피롤리딘-１,２-디카르복실산-１-(페닐(-아미드))-２-(페닐(-아미드)) 유도체 및１-(페닐카르바모일)-피롤리딘-2-카르복실산 유도체의 제조방법 Download PDFInfo
- Publication number
- KR20050118709A KR20050118709A KR1020057018640A KR20057018640A KR20050118709A KR 20050118709 A KR20050118709 A KR 20050118709A KR 1020057018640 A KR1020057018640 A KR 1020057018640A KR 20057018640 A KR20057018640 A KR 20057018640A KR 20050118709 A KR20050118709 A KR 20050118709A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- oxomorpholin
- phenyl
- compound
- chlorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 238000000034 method Methods 0.000 title claims abstract description 55
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 239000013067 intermediate product Substances 0.000 title abstract 2
- ZEEAHHXBZHTCOI-UHFFFAOYSA-N 1-(phenylcarbamoyl)pyrrolidine-2-carboxylic acid Chemical class OC(=O)C1CCCN1C(=O)NC1=CC=CC=C1 ZEEAHHXBZHTCOI-UHFFFAOYSA-N 0.000 title 1
- OAWXZFGKDDFTGS-UHFFFAOYSA-N pyrrolidine-1,2-dicarboxylic acid Chemical compound OC(=O)C1CCCN1C(O)=O OAWXZFGKDDFTGS-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 73
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- -1 COOA Chemical group 0.000 claims description 163
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 39
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 33
- 239000000203 mixture Substances 0.000 claims description 30
- 239000012453 solvate Substances 0.000 claims description 27
- 125000004432 carbon atom Chemical group C* 0.000 claims description 21
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- 238000006243 chemical reaction Methods 0.000 claims description 15
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- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
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- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 125000005500 uronium group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10315377A DE10315377A1 (de) | 2003-04-03 | 2003-04-03 | Carbonylverbindungen |
| DE10315377.2 | 2003-04-03 | ||
| DE10327428A DE10327428A1 (de) | 2003-06-18 | 2003-06-18 | Ethinylprolinderivate |
| DE10327428.6 | 2003-06-18 | ||
| DE10329295.0 | 2003-06-30 | ||
| DE2003129295 DE10329295A1 (de) | 2003-06-30 | 2003-06-30 | Carbonylverbindungen |
| DE10329457.0 | 2003-07-01 | ||
| DE10329457A DE10329457A1 (de) | 2003-04-03 | 2003-07-01 | Ethinylprolinderivate |
| DE2003134174 DE10334174A1 (de) | 2003-07-26 | 2003-07-26 | Pyrrolidinderivate und Verfahren zur Herstellung |
| DE10334174.9 | 2003-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20050118709A true KR20050118709A (ko) | 2005-12-19 |
Family
ID=33136213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057018640A Withdrawn KR20050118709A (ko) | 2003-04-03 | 2004-03-09 | 중간체 생성물로서의피롤리딘-１,２-디카르복실산-１-(페닐(-아미드))-２-(페닐(-아미드)) 유도체 및１-(페닐카르바모일)-피롤리딘-2-카르복실산 유도체의 제조방법 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7504500B2 (https=) |
| EP (1) | EP1608646B1 (https=) |
| JP (1) | JP4634369B2 (https=) |
| KR (1) | KR20050118709A (https=) |
| AR (1) | AR043831A1 (https=) |
| AT (1) | ATE366732T1 (https=) |
| AU (1) | AU2004226280B2 (https=) |
| BR (1) | BRPI0408888A (https=) |
| CA (1) | CA2520893C (https=) |
| DE (2) | DE10329457A1 (https=) |
| ES (1) | ES2287708T3 (https=) |
| MX (1) | MXPA05010433A (https=) |
| PE (1) | PE20050395A1 (https=) |
| PL (1) | PL377138A1 (https=) |
| TW (1) | TW200500339A (https=) |
| WO (1) | WO2004087695A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050119266A1 (en) * | 2003-10-01 | 2005-06-02 | Yan Shi | Pyrrolidine and piperidine derivatives as factor Xa inhibitors |
| DE102004004731A1 (de) * | 2004-01-30 | 2005-08-18 | Merck Patent Gmbh | Harnstoffderivate |
| DE102004045796A1 (de) * | 2004-09-22 | 2006-03-23 | Merck Patent Gmbh | Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung |
| DE102004047254A1 (de) * | 2004-09-29 | 2006-04-13 | Merck Patent Gmbh | Carbonylverbindungen |
| DE102004050283A1 (de) * | 2004-10-15 | 2006-04-27 | Lanxess Deutschland Gmbh | 4-Aminophenyl-morpholinon-Derivate und deren Herstellung |
| US7301817B2 (en) * | 2005-10-27 | 2007-11-27 | Sandisk Corporation | Method for programming of multi-state non-volatile memory using smart verify |
| EP1951717A1 (en) * | 2005-11-16 | 2008-08-06 | F.Hoffmann-La Roche Ag | Novel pyrrolidine derivatives as inhibitors of coagulation factor xa |
| EP1818330A1 (de) | 2006-02-14 | 2007-08-15 | Boehringer Ingelheim Pharma GmbH & Co.KG | Substituierte Prolinamide, deren Herstellung und deren Verwendung als Arzneimittel |
| MY146623A (en) | 2006-05-16 | 2012-09-14 | Boehringer Ingelheim Int | Substituted prolinamides, manufacturing, and the use thereof as medicaments |
| US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2012058116A1 (en) | 2010-10-27 | 2012-05-03 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2632464B1 (en) | 2010-10-29 | 2015-04-29 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| AU2012299227A1 (en) | 2011-08-19 | 2014-02-20 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2013039802A1 (en) | 2011-09-16 | 2013-03-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2771004B1 (en) | 2011-10-25 | 2016-05-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US8999990B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2013066714A1 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2773206B1 (en) | 2011-10-31 | 2018-02-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2773351B1 (en) | 2011-10-31 | 2017-08-23 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2790511B1 (en) | 2011-12-16 | 2016-09-14 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| AR092031A1 (es) | 2012-07-26 | 2015-03-18 | Merck Sharp & Dohme | Inhibidores del canal de potasio medular externo renal |
| EP2925322B1 (en) | 2012-11-29 | 2018-10-24 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US9573961B2 (en) | 2012-12-19 | 2017-02-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2014126944A2 (en) | 2013-02-18 | 2014-08-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2968288B1 (en) | 2013-03-15 | 2018-07-04 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP3027625B1 (en) | 2013-07-31 | 2018-05-30 | Merck Sharp & Dohme Corp. | Spiro-fused derivatives of piperidine useful for the treatment of inter alia hypertension and acute or chronic heart failure |
| WO2015065866A1 (en) | 2013-10-31 | 2015-05-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5822111B2 (ja) * | 1977-10-29 | 1983-05-06 | 協和醗酵工業株式会社 | 柑橘類果実の改質剤 |
| JPS63232846A (ja) * | 1987-03-20 | 1988-09-28 | Haruo Ogura | 新規な固定相担体 |
| WO1998022432A1 (en) * | 1996-11-18 | 1998-05-28 | Yamanouchi Pharmaceutical Co., Ltd. | Novel acylamino-substituted acylanilide derivatives or pharmaceutical composition comprising the same |
| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
-
2003
- 2003-07-01 DE DE10329457A patent/DE10329457A1/de not_active Withdrawn
-
2004
- 2004-03-09 AT AT04718646T patent/ATE366732T1/de not_active IP Right Cessation
- 2004-03-09 ES ES04718646T patent/ES2287708T3/es not_active Expired - Lifetime
- 2004-03-09 DE DE502004004294T patent/DE502004004294D1/de not_active Expired - Lifetime
- 2004-03-09 MX MXPA05010433A patent/MXPA05010433A/es not_active Application Discontinuation
- 2004-03-09 EP EP04718646A patent/EP1608646B1/de not_active Expired - Lifetime
- 2004-03-09 AU AU2004226280A patent/AU2004226280B2/en not_active Ceased
- 2004-03-09 US US10/551,670 patent/US7504500B2/en not_active Expired - Fee Related
- 2004-03-09 BR BRPI0408888-3A patent/BRPI0408888A/pt not_active Application Discontinuation
- 2004-03-09 WO PCT/EP2004/002405 patent/WO2004087695A1/de not_active Ceased
- 2004-03-09 KR KR1020057018640A patent/KR20050118709A/ko not_active Withdrawn
- 2004-03-09 JP JP2006504602A patent/JP4634369B2/ja not_active Expired - Fee Related
- 2004-03-09 PL PL377138A patent/PL377138A1/pl unknown
- 2004-03-09 CA CA2520893A patent/CA2520893C/en not_active Expired - Fee Related
- 2004-03-31 TW TW093108904A patent/TW200500339A/zh unknown
- 2004-04-02 PE PE2004000349A patent/PE20050395A1/es not_active Application Discontinuation
- 2004-04-02 AR ARP040101113A patent/AR043831A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2520893C (en) | 2012-07-10 |
| ES2287708T3 (es) | 2007-12-16 |
| AR043831A1 (es) | 2005-08-17 |
| TW200500339A (en) | 2005-01-01 |
| AU2004226280A1 (en) | 2004-10-14 |
| EP1608646A1 (de) | 2005-12-28 |
| US20060211692A1 (en) | 2006-09-21 |
| EP1608646B1 (de) | 2007-07-11 |
| PL377138A1 (pl) | 2006-01-23 |
| BRPI0408888A (pt) | 2006-04-11 |
| MXPA05010433A (es) | 2005-11-04 |
| DE502004004294D1 (de) | 2007-08-23 |
| US7504500B2 (en) | 2009-03-17 |
| CA2520893A1 (en) | 2004-10-14 |
| ATE366732T1 (de) | 2007-08-15 |
| JP2006522037A (ja) | 2006-09-28 |
| DE10329457A1 (de) | 2005-01-20 |
| AU2004226280B2 (en) | 2010-06-17 |
| WO2004087695A1 (de) | 2004-10-14 |
| PE20050395A1 (es) | 2005-06-04 |
| JP4634369B2 (ja) | 2011-02-16 |
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