KR20050098250A - 에너골리틱제를 사용한 양성 전립선 비대증의 치료 방법 - Google Patents
에너골리틱제를 사용한 양성 전립선 비대증의 치료 방법 Download PDFInfo
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- KR20050098250A KR20050098250A KR1020057013200A KR20057013200A KR20050098250A KR 20050098250 A KR20050098250 A KR 20050098250A KR 1020057013200 A KR1020057013200 A KR 1020057013200A KR 20057013200 A KR20057013200 A KR 20057013200A KR 20050098250 A KR20050098250 A KR 20050098250A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/342—Prostate diseases, e.g. BPH, prostatitis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
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| US44111003P | 2003-01-17 | 2003-01-17 | |
| US60/441,110 | 2003-01-17 | ||
| US44234403P | 2003-01-23 | 2003-01-23 | |
| US60/442,344 | 2003-01-23 | ||
| US45866303P | 2003-03-28 | 2003-03-28 | |
| US45884603P | 2003-03-28 | 2003-03-28 | |
| US45866503P | 2003-03-28 | 2003-03-28 | |
| US60/458,846 | 2003-03-28 | ||
| US60/458,665 | 2003-03-28 | ||
| US60/458,663 | 2003-03-28 | ||
| US46001203P | 2003-04-02 | 2003-04-02 | |
| US60/460,012 | 2003-04-02 | ||
| US47290703P | 2003-05-22 | 2003-05-22 | |
| US60/472,907 | 2003-05-22 | ||
| US48826503P | 2003-07-18 | 2003-07-18 | |
| US60/488,265 | 2003-07-18 | ||
| US49616303P | 2003-08-18 | 2003-08-18 | |
| US60/496,163 | 2003-08-18 |
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| KR20050098250A true KR20050098250A (ko) | 2005-10-11 |
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| KR1020057013198A Withdrawn KR20050098249A (ko) | 2003-01-17 | 2004-01-16 | 양성 전립선 비대증의 치료방법 |
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| KR1020057013198A Withdrawn KR20050098249A (ko) | 2003-01-17 | 2004-01-16 | 양성 전립선 비대증의 치료방법 |
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| US (4) | US6989400B2 (https=) |
| EP (2) | EP1592430A4 (https=) |
| JP (2) | JP2006516571A (https=) |
| KR (2) | KR20050098250A (https=) |
| AU (2) | AU2004206869A1 (https=) |
| BR (1) | BRPI0406796A (https=) |
| CA (2) | CA2513572A1 (https=) |
| DE (1) | DE04702967T1 (https=) |
| ES (1) | ES2254046T1 (https=) |
| IL (1) | IL169685A0 (https=) |
| MX (2) | MXPA05007572A (https=) |
| NO (1) | NO20053783L (https=) |
| WO (2) | WO2004064736A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7795227B2 (en) | 2004-06-17 | 2010-09-14 | Wisconsin Alumni Research Foundation | Compounds and methods for treating seizure disorders |
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| US7547673B2 (en) * | 2001-09-13 | 2009-06-16 | The Johns Hopkins University | Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production |
| US7524885B2 (en) * | 2002-04-01 | 2009-04-28 | The Governors Of The University Of Alberta | Compounds that stimulate glucose utilization and methods of use |
| EP1592430A4 (en) | 2003-01-17 | 2006-05-31 | Threshold Pharmaceuticals Inc | TREATMENT OF GOOD PROSTATE HYPERPLASIA BY MEANS OF ENERGYSTIC ACTIVE SUBSTANCES |
| US7208611B2 (en) | 2005-02-23 | 2007-04-24 | Xenoport, Inc. | Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use |
| US20060287253A1 (en) * | 2005-06-17 | 2006-12-21 | Kriegler Steven M | Compounds and methods for treating seizure disorders |
| US8324175B2 (en) | 2006-02-16 | 2012-12-04 | Young Hee Ko | Compositions and methods for the treatment of cancer |
| AU2007220777A1 (en) * | 2006-02-24 | 2007-09-07 | Board Of Regents, The University Of Texas System | Hexose compounds to treat cancer |
| EP1990335A4 (en) | 2006-03-02 | 2009-11-11 | Astellas Pharma Inc | 17-BETA-HSD-type-5 INHIBITOR |
| WO2008076964A1 (en) * | 2006-12-18 | 2008-06-26 | The Johns Hopkins University | Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of atp production |
| US20080245375A1 (en) * | 2007-04-05 | 2008-10-09 | Medtronic Vascular, Inc. | Benign Prostatic Hyperplasia Treatments |
| EP2172454A4 (en) | 2007-07-24 | 2010-12-08 | Astellas Pharma Inc | benzimidazole derivative |
| US8513422B2 (en) | 2007-08-31 | 2013-08-20 | Astellas Pharma Inc. | Piperidine derivative |
| US8603123B2 (en) | 2008-04-28 | 2013-12-10 | Urotech, Inc. | Benign prostatic hyperplasia surgical system featuring mechanical coring probe with live aspiration |
| US9492417B2 (en) | 2008-08-21 | 2016-11-15 | The Johns Hopkins University | Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer |
| CA3024263A1 (en) * | 2009-01-29 | 2010-08-05 | Young Hee Ko | Compositions and methods for the treatment of cancer |
| WO2013153821A1 (ja) * | 2012-04-12 | 2013-10-17 | Omura Satoshi | Pdk4阻害剤及びその利用 |
| US10441561B2 (en) | 2012-07-26 | 2019-10-15 | The William M. Yanbrough Foundation | Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer |
| WO2015108933A1 (en) | 2014-01-14 | 2015-07-23 | The Johns Hopkins University | Cyclodextrin compositions encapsulating a selective atp inhibitor and uses thereof |
| WO2017079563A1 (en) | 2015-11-06 | 2017-05-11 | The Johns Hopkins University | Methods of treating liver fibrosis by administering 3-bromopyruvate |
| EP3564214B1 (en) | 2018-05-04 | 2024-07-03 | Universita' Degli Studi G. D'annunzio Chieti - Pescara | Indazole derivatives as modulators of the cannabinoid system |
| WO2022061008A2 (en) * | 2020-09-17 | 2022-03-24 | Escient Pharmaceuticals, Inc. | Modulators of mas-related g-protein receptor x4 and related products and methods |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1052111B (it) * | 1972-02-29 | 1981-06-20 | Acraf | Acidi i benzil i h indazol 3 carbossilici sostituiti e loro derivati |
| US4684627A (en) * | 1981-09-08 | 1987-08-04 | Leveen Harry H | Treatment of cancer with phlorizin and its derivatives |
| CA1289077C (en) * | 1984-08-13 | 1991-09-17 | Harry H. Leveen | Treatment of cancer with phlorizin and its derivatives |
| US5260327A (en) * | 1985-10-02 | 1993-11-09 | Sloan-Kettering Institute For Cancer Research | Methods for inhibiting the proliferation of brain and hepatic metastases by using lonidamine |
| AU1893492A (en) * | 1991-04-17 | 1992-11-17 | Merck & Co., Inc. | Pharmaceutical combination for the treatment of benign prostatic hyperplasia comtaining a 5 alpha-reductase inhibitor |
| US6063911A (en) * | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
| US5654320A (en) * | 1995-03-16 | 1997-08-05 | Eli Lilly And Company | Indazolecarboxamides |
| ATE247469T1 (de) | 1995-06-07 | 2003-09-15 | Pfizer | Heterocyclische kondensierte pyrimidin-derivate |
| FR2737721B1 (fr) * | 1995-08-08 | 1997-09-05 | Roussel Uclaf | Nouveaux composes biphenyles, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicament et les compositions pharmaceutiques les contenant |
| EP0797564B1 (en) | 1995-10-18 | 2001-06-27 | Kanoldt Arzneimittel Gmbh | Lignans, a process for their production and pharmaceutical compositions and uses thereof |
| DE19621319A1 (de) | 1996-05-28 | 1997-12-04 | Hoechst Ag | Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US6054432A (en) | 1996-09-12 | 2000-04-25 | Asta Medica Aktiengesellschaft | Means for treating prostate hypertrophy and prostate cancer |
| IT1289939B1 (it) * | 1997-02-20 | 1998-10-19 | Angelini Ricerche Spa | Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua |
| IT1289938B1 (it) * | 1997-02-20 | 1998-10-19 | Angelini Ricerche Spa | Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e |
| CN1078462C (zh) * | 1997-07-09 | 2002-01-30 | 辛国芳 | 棉酚和/或其衍生物作为有效成分在制备用于治疗前列腺炎的栓剂中的应用 |
| CA2331620A1 (en) * | 1998-05-11 | 1999-11-18 | The Endowment For Research In Human Biology, Inc. | Use of neomycin for treating angiogenesis-related diseases |
| US6428968B1 (en) * | 1999-03-15 | 2002-08-06 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
| US6001865A (en) * | 1999-05-04 | 1999-12-14 | Angelini Pharmaceuticals Inc. | 3-substituted 1-benzyl-1H-indazole derivatives as antifertility agents |
| EP1592430A4 (en) | 2003-01-17 | 2006-05-31 | Threshold Pharmaceuticals Inc | TREATMENT OF GOOD PROSTATE HYPERPLASIA BY MEANS OF ENERGYSTIC ACTIVE SUBSTANCES |
| EA011218B1 (ru) * | 2004-03-25 | 2009-02-27 | Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган | Сокристаллы госсипола и их применение |
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- 2005-07-14 IL IL169685A patent/IL169685A0/en unknown
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7795227B2 (en) | 2004-06-17 | 2010-09-14 | Wisconsin Alumni Research Foundation | Compounds and methods for treating seizure disorders |
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| US20050272796A1 (en) | 2005-12-08 |
| EP1610778A4 (en) | 2006-05-31 |
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| NO20053783L (no) | 2005-09-27 |
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| JP2006518343A (ja) | 2006-08-10 |
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| EP1592430A2 (en) | 2005-11-09 |
| WO2004064736A2 (en) | 2004-08-05 |
| WO2004064735A3 (en) | 2004-12-16 |
| KR20050098249A (ko) | 2005-10-11 |
| WO2004064735A2 (en) | 2004-08-05 |
| US6989400B2 (en) | 2006-01-24 |
| AU2004206870A1 (en) | 2004-08-05 |
| JP2006516571A (ja) | 2006-07-06 |
| MXPA05007572A (es) | 2005-11-17 |
| BRPI0406796A (pt) | 2006-01-17 |
| CA2513572A1 (en) | 2004-08-05 |
| EP1592430A4 (en) | 2006-05-31 |
| US20040167196A1 (en) | 2004-08-26 |
| US20050272795A1 (en) | 2005-12-08 |
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