KR20050086664A - 미세구조화된 중합체성 기질 - Google Patents
미세구조화된 중합체성 기질 Download PDFInfo
- Publication number
- KR20050086664A KR20050086664A KR1020057008731A KR20057008731A KR20050086664A KR 20050086664 A KR20050086664 A KR 20050086664A KR 1020057008731 A KR1020057008731 A KR 1020057008731A KR 20057008731 A KR20057008731 A KR 20057008731A KR 20050086664 A KR20050086664 A KR 20050086664A
- Authority
- KR
- South Korea
- Prior art keywords
- microstructured
- substrate
- analyte
- polymeric
- film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000758 substrate Substances 0.000 title claims abstract description 105
- 238000000576 coating method Methods 0.000 claims abstract description 84
- 238000000034 method Methods 0.000 claims abstract description 39
- 238000003795 desorption Methods 0.000 claims abstract description 34
- 238000004949 mass spectrometry Methods 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 239000004743 Polypropylene Substances 0.000 claims description 94
- -1 polypropylenes Polymers 0.000 claims description 89
- 229920001155 polypropylene Polymers 0.000 claims description 87
- 239000012491 analyte Substances 0.000 claims description 71
- 239000011248 coating agent Substances 0.000 claims description 61
- 239000011159 matrix material Substances 0.000 claims description 58
- 239000002184 metal Substances 0.000 claims description 50
- 229910052751 metal Inorganic materials 0.000 claims description 49
- 239000000463 material Substances 0.000 claims description 30
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 28
- 229910002804 graphite Inorganic materials 0.000 claims description 25
- 239000010439 graphite Substances 0.000 claims description 25
- 239000004417 polycarbonate Substances 0.000 claims description 20
- 229920000515 polycarbonate Polymers 0.000 claims description 19
- 229910044991 metal oxide Inorganic materials 0.000 claims description 14
- 150000004706 metal oxides Chemical class 0.000 claims description 14
- 239000011521 glass Substances 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 4
- 239000012815 thermoplastic material Substances 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims 1
- 238000012795 verification Methods 0.000 claims 1
- 238000004458 analytical method Methods 0.000 abstract description 18
- 239000010408 film Substances 0.000 description 166
- 238000001819 mass spectrum Methods 0.000 description 79
- 229910052782 aluminium Inorganic materials 0.000 description 50
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 49
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 45
- 239000000523 sample Substances 0.000 description 41
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 38
- 229960002896 clonidine Drugs 0.000 description 38
- 238000001228 spectrum Methods 0.000 description 31
- 239000000243 solution Substances 0.000 description 28
- 239000010410 layer Substances 0.000 description 23
- 108090000765 processed proteins & peptides Proteins 0.000 description 23
- AFVLVVWMAFSXCK-VMPITWQZSA-N alpha-cyano-4-hydroxycinnamic acid Chemical compound OC(=O)C(\C#N)=C\C1=CC=C(O)C=C1 AFVLVVWMAFSXCK-VMPITWQZSA-N 0.000 description 21
- 239000000126 substance Substances 0.000 description 20
- 150000003384 small molecules Chemical class 0.000 description 19
- 239000000853 adhesive Substances 0.000 description 17
- 230000001070 adhesive effect Effects 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 102400000967 Bradykinin Human genes 0.000 description 15
- 101800004538 Bradykinin Proteins 0.000 description 15
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 description 15
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 description 15
- 101800000733 Angiotensin-2 Proteins 0.000 description 14
- 102400000345 Angiotensin-2 Human genes 0.000 description 14
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 description 14
- 229950006323 angiotensin ii Drugs 0.000 description 14
- 229920006289 polycarbonate film Polymers 0.000 description 14
- 238000001125 extrusion Methods 0.000 description 12
- 238000004128 high performance liquid chromatography Methods 0.000 description 12
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 11
- 150000001793 charged compounds Chemical class 0.000 description 11
- 229910052710 silicon Inorganic materials 0.000 description 11
- 239000010703 silicon Substances 0.000 description 11
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 8
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 8
- 229960001289 prazosin Drugs 0.000 description 8
- 238000010790 dilution Methods 0.000 description 7
- 239000012895 dilution Substances 0.000 description 7
- 238000000746 purification Methods 0.000 description 7
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 238000001878 scanning electron micrograph Methods 0.000 description 6
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 description 5
- 229930182555 Penicillin Natural products 0.000 description 5
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 229960005070 ascorbic acid Drugs 0.000 description 5
- 235000010323 ascorbic acid Nutrition 0.000 description 5
- 239000011668 ascorbic acid Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 238000004049 embossing Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 150000002739 metals Chemical class 0.000 description 5
- 229960005489 paracetamol Drugs 0.000 description 5
- 229940049954 penicillin Drugs 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 230000003595 spectral effect Effects 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 238000012876 topography Methods 0.000 description 5
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 description 4
- WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 102400000096 Substance P Human genes 0.000 description 4
- 101800003906 Substance P Proteins 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 238000000151 deposition Methods 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 229920000052 poly(p-xylylene) Polymers 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 239000002243 precursor Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 150000004756 silanes Chemical class 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- AFVLVVWMAFSXCK-UHFFFAOYSA-N α-cyano-4-hydroxycinnamic acid Chemical compound OC(=O)C(C#N)=CC1=CC=C(O)C=C1 AFVLVVWMAFSXCK-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- 239000000956 alloy Substances 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- 238000000748 compression moulding Methods 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 229960003878 haloperidol Drugs 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- GLDQAMYCGOIJDV-UHFFFAOYSA-N 2,3-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC(O)=C1O GLDQAMYCGOIJDV-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- NZNMSOFKMUBTKW-UHFFFAOYSA-N Cyclohexanecarboxylic acid Natural products OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002390 adhesive tape Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 238000003490 calendering Methods 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 238000005229 chemical vapour deposition Methods 0.000 description 2
- 238000005253 cladding Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229910003460 diamond Inorganic materials 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004070 electrodeposition Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000000752 ionisation method Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000000608 laser ablation Methods 0.000 description 2
- 238000001869 matrix assisted laser desorption--ionisation mass spectrum Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 229910001092 metal group alloy Inorganic materials 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000009832 plasma treatment Methods 0.000 description 2
- 239000002985 plastic film Substances 0.000 description 2
- 229920006255 plastic film Polymers 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920000379 polypropylene carbonate Polymers 0.000 description 2
- 229920005606 polypropylene copolymer Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 150000003109 potassium Chemical class 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000004834 spray adhesive Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- ZZHVXIPXTCBVBE-UHFFFAOYSA-N 5-(diaminomethylideneamino)-2-[[2-[[1-[3-hydroxy-2-[[3-phenyl-2-[[2-[[1-(pyrrolidine-2-carbonyl)pyrrolidine-2-carbonyl]amino]acetyl]amino]propanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]pentanoic acid Chemical compound C1CCN(C(=O)C(CO)NC(=O)C(CC=2C=CC=CC=2)NC(=O)CNC(=O)C2N(CCC2)C(=O)C2NCCC2)C1C(=O)NC(C(=O)NC(CCCN=C(N)N)C(O)=O)CC1=CC=CC=C1 ZZHVXIPXTCBVBE-UHFFFAOYSA-N 0.000 description 1
- 102400000344 Angiotensin-1 Human genes 0.000 description 1
- 101800000734 Angiotensin-1 Proteins 0.000 description 1
- 102100024099 Disks large homolog 1 Human genes 0.000 description 1
- 101001053984 Homo sapiens Disks large homolog 1 Proteins 0.000 description 1
- 229920004030 Makrolon® 2407 Polymers 0.000 description 1
- 102400001103 Neurotensin Human genes 0.000 description 1
- 101800001814 Neurotensin Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000538 analytical sample Substances 0.000 description 1
- ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001721 carbon Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 238000000541 cathodic arc deposition Methods 0.000 description 1
- 238000003486 chemical etching Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920006026 co-polymeric resin Polymers 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 238000002288 cocrystallisation Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000003851 corona treatment Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000007756 gravure coating Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 229910001026 inconel Inorganic materials 0.000 description 1
- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 239000012939 laminating adhesive Substances 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 238000001459 lithography Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000010128 melt processing Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- PCJGZPGTCUMMOT-ISULXFBGSA-N neurotensin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 PCJGZPGTCUMMOT-ISULXFBGSA-N 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 238000005240 physical vapour deposition Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000001020 plasma etching Methods 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000010345 tape casting Methods 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 238000002061 vacuum sublimation Methods 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 229910052845 zircon Inorganic materials 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
- G01N27/623—Ion mobility spectrometry combined with mass spectrometry
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0409—Sample holders or containers
- H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
- H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Plasma & Fusion (AREA)
- Pathology (AREA)
- Nanotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Electrochemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/299,962 | 2002-11-18 | ||
| US10/299,962 US7105809B2 (en) | 2002-11-18 | 2002-11-18 | Microstructured polymeric substrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20050086664A true KR20050086664A (ko) | 2005-08-30 |
Family
ID=32297813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057008731A Withdrawn KR20050086664A (ko) | 2002-11-18 | 2003-10-07 | 미세구조화된 중합체성 기질 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7105809B2 (enExample) |
| EP (1) | EP1563525A2 (enExample) |
| JP (1) | JP2006506641A (enExample) |
| KR (1) | KR20050086664A (enExample) |
| CN (1) | CN1711622A (enExample) |
| AU (1) | AU2003279871A1 (enExample) |
| CA (1) | CA2502919A1 (enExample) |
| WO (1) | WO2004047142A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10230328B4 (de) * | 2002-07-05 | 2007-09-20 | Bruker Daltonik Gmbh | Probenträger für Massenspektrometrie |
| DE10322701B4 (de) * | 2003-05-20 | 2006-12-28 | Humboldt-Universität Zu Berlin | Probenträger unter Verwendung eines porösen, Metalloxidpartikel umfassenden Films, Verfahren zur Herstellung eines Probenträgers, Verwendung des Probenträgers sowie Verfahren zum selektiven Nachweis von phosphorylierten/sulfatierten Biopolymeren, insbesondere Peptiden/Proteinen |
| CA2527701A1 (en) * | 2003-06-06 | 2005-01-06 | J. Albert Schultz | Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues |
| KR20040105360A (ko) * | 2003-06-07 | 2004-12-16 | 삼성전자주식회사 | 레이저 탈착/이온화 질량 분석용 시료 홀더 및 그 제조방법 |
| US7462494B2 (en) * | 2003-06-09 | 2008-12-09 | 3M Innovative Properties Company | Method for laser desorption mass spectrometry using porous polymeric substrates with particle fillers |
| US7170052B2 (en) * | 2003-12-31 | 2007-01-30 | Ionwerks, Inc. | MALDI-IM-ortho-TOF mass spectrometry with simultaneous positive and negative mode detection |
| JP4512589B2 (ja) * | 2004-02-26 | 2010-07-28 | 独立行政法人科学技術振興機構 | 表面加工が施された試料保持面を有する試料ターゲットおよびその製造方法、並びに当該試料ターゲットを用いた質量分析装置 |
| US20100090101A1 (en) * | 2004-06-04 | 2010-04-15 | Ionwerks, Inc. | Gold implantation/deposition of biological samples for laser desorption two and three dimensional depth profiling of biological tissues |
| WO2006118595A2 (en) * | 2004-09-17 | 2006-11-09 | Nanosys, Inc. | Nanostructured thin films and their uses |
| US8294090B1 (en) * | 2004-10-29 | 2012-10-23 | Japan Science And Technology Agency | Substrate for MALDI-TOF MS and mass spectrometry method using the same |
| DE102004053458A1 (de) * | 2004-11-05 | 2006-05-11 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Strukturierte polymere Träger für die Massenspektrometrie und Verfahren zu deren Herstellung |
| JP4576606B2 (ja) * | 2005-01-21 | 2010-11-10 | 独立行政法人産業技術総合研究所 | 質量分析用イオン化基板及び質量分析装置 |
| US20070014997A1 (en) * | 2005-07-14 | 2007-01-18 | 3M Innovative Properties Company | Tool and method of making and using the same |
| US7906057B2 (en) * | 2005-07-14 | 2011-03-15 | 3M Innovative Properties Company | Nanostructured article and method of making the same |
| US7651863B2 (en) * | 2005-07-14 | 2010-01-26 | 3M Innovative Properties Company | Surface-enhanced spectroscopic method, flexible structured substrate, and method of making the same |
| JP4885142B2 (ja) * | 2005-10-20 | 2012-02-29 | 独立行政法人科学技術振興機構 | 質量分析法に用いられる試料ターゲットおよびその製造方法、並びに当該試料ターゲットを用いた質量分析装置 |
| EP1814137A3 (en) * | 2006-01-27 | 2008-04-23 | Sony DADC Austria AG | Mass spectrometry target assembly |
| AT504100B9 (de) * | 2006-08-25 | 2009-12-15 | Leopold Franzens Uni Innsbruck | Matrix-freie maldi massenspektrometrie |
| US8513322B2 (en) * | 2007-05-31 | 2013-08-20 | 3M Innovative Properties Company | Polymeric beads and methods of making polymeric beads |
| US20090114618A1 (en) * | 2007-06-21 | 2009-05-07 | 3M Innovative Properties Company | Method of making hierarchical articles |
| US20090041986A1 (en) * | 2007-06-21 | 2009-02-12 | 3M Innovative Properties Company | Method of making hierarchical articles |
| JP5013421B2 (ja) * | 2007-09-26 | 2012-08-29 | 公立大学法人首都大学東京 | グラファイト基板を利用した質量分析 |
| US7772556B2 (en) * | 2007-11-14 | 2010-08-10 | University Of Maine System Board Of Trustees | Detection system for detecting an analyte in a fluid medium |
| JP5432175B2 (ja) | 2007-12-12 | 2014-03-05 | スリーエム イノベイティブ プロパティズ カンパニー | 物品の製造方法及び物品 |
| BRPI0820704A2 (pt) * | 2007-12-12 | 2015-06-16 | 3M Innovative Proferties Company | Métodos de fabricação de materiais poliméricos moldados |
| US7888127B2 (en) * | 2008-01-15 | 2011-02-15 | Sequenom, Inc. | Methods for reducing adduct formation for mass spectrometry analysis |
| US8431671B2 (en) * | 2008-03-26 | 2013-04-30 | 3M Innovative Properties Company | Structured polydiorganosiloxane polyamide containing devices and methods |
| US8318265B2 (en) * | 2008-06-12 | 2012-11-27 | General Electric Company | Plasma mediated processing of non-conductive substrates |
| CN102124825B (zh) * | 2008-06-30 | 2014-04-30 | 3M创新有限公司 | 形成图案化基材的方法 |
| JP2011526844A (ja) | 2008-06-30 | 2011-10-20 | スリーエム イノベイティブ プロパティズ カンパニー | ミクロ構造を形成する方法 |
| CN103155725B (zh) * | 2010-10-22 | 2016-07-06 | 索尼公司 | 图案基板、图案基板的制造方法、信息输入装置和显示装置 |
| US8530021B2 (en) | 2011-03-08 | 2013-09-10 | 3M Innovative Properties Company | Microstructured tape |
| US10079139B2 (en) * | 2011-03-17 | 2018-09-18 | Kent J. Voorhees | Metal oxide laser ionization-mass spectrometry |
| CA2832907C (en) | 2011-04-19 | 2020-07-14 | Dako Denmark A/S | New method for enzyme-mediated signal amplification |
| CN102539515A (zh) * | 2011-12-27 | 2012-07-04 | 北京大学 | 常温常压表面辅助激光解吸附质谱的高灵敏度检测方法 |
| JP5993678B2 (ja) * | 2012-09-14 | 2016-09-14 | 日本電子株式会社 | マスイメージング装置及びマスイメージング装置の制御方法 |
| WO2014135864A1 (en) * | 2013-03-05 | 2014-09-12 | Micromass Uk Limited | Charging plate for enhancing multiply charged ions by laser desorption |
| KR20150052898A (ko) * | 2013-11-06 | 2015-05-15 | 연세대학교 산학협력단 | 말디톱 질량분석기에 이용가능한 시료 플레이트 및 상기 시료 플레이트의 제조방법 |
| US20150243404A1 (en) * | 2014-02-23 | 2015-08-27 | Nano And Advanced Materials Institute Limited | Polydimethylsiloxane (PDMS) Based Composite and Synthesis Method Thereof |
| CN104867806B (zh) * | 2014-02-24 | 2018-05-01 | 岛津分析技术研发（上海）有限公司 | 用于解吸附样品的进样方法和装置 |
| JP6796371B2 (ja) | 2014-11-28 | 2020-12-09 | デクセリアルズ株式会社 | マイクロ流路作製用原盤の製造方法 |
| JP6717298B2 (ja) * | 2015-05-08 | 2020-07-01 | Ａｇｃ株式会社 | 質量分析用試料プレート、質量分析方法および質量分析装置 |
| CN107849437B (zh) | 2015-07-08 | 2020-06-05 | 3M创新有限公司 | 包含多金属氧酸盐的光致变色制品及其制备和使用方法 |
| WO2018102266A1 (en) | 2016-12-02 | 2018-06-07 | 3M Innovative Properties Company | Photochromic articles containing a porous material with a photochromic dye and fluid, methods of making and using |
| CN109161851B (zh) * | 2018-07-28 | 2019-08-30 | 华中科技大学 | 一种基于激光诱导的超亲水pet表面的制备方法及产品 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3125335A1 (de) * | 1981-06-27 | 1983-01-13 | Alfred Prof. Dr. 4400 Münster Benninghoven | Verfahren zur analyse von gasen und fluessigkeiten |
| DE3221681A1 (de) | 1982-06-08 | 1983-12-08 | Bayer Ag, 5090 Leverkusen | Massenspektrometer mit externer probenhalterung |
| GB2257295B (en) * | 1991-06-21 | 1994-11-16 | Finnigan Mat Ltd | Sample holder for use in a mass spectrometer |
| US6020208A (en) * | 1994-05-27 | 2000-02-01 | Baylor College Of Medicine | Systems for surface-enhanced affinity capture for desorption and detection of analytes |
| DE69432791T2 (de) * | 1993-05-28 | 2004-06-03 | Baylor College Of Medicine, Houston | Verfahren und massenspektrometer zur desorption und ionisierung von analyten |
| US6440880B2 (en) * | 1993-10-29 | 2002-08-27 | 3M Innovative Properties Company | Pressure-sensitive adhesives having microstructured surfaces |
| US5498545A (en) * | 1994-07-21 | 1996-03-12 | Vestal; Marvin L. | Mass spectrometer system and method for matrix-assisted laser desorption measurements |
| US5795648A (en) * | 1995-10-03 | 1998-08-18 | Advanced Refractory Technologies, Inc. | Method for preserving precision edges using diamond-like nanocomposite film coatings |
| US5777324A (en) * | 1996-09-19 | 1998-07-07 | Sequenom, Inc. | Method and apparatus for maldi analysis |
| US5854486A (en) * | 1996-12-27 | 1998-12-29 | R. T. Hodgson | Method and apparatus for MALDI mass spectrometry |
| US5882496A (en) * | 1997-02-27 | 1999-03-16 | The Regents Of The University Of California | Porous silicon structures with high surface area/specific pore size |
| US6265068B1 (en) * | 1997-11-26 | 2001-07-24 | 3M Innovative Properties Company | Diamond-like carbon coatings on inorganic phosphors |
| US5948610A (en) * | 1998-06-03 | 1999-09-07 | University Of Maryland At Baltimore County | Use of matrices comprising liquids and light absorbing particles for analysis of microorganisms by laser desorption mass spectrometry |
| WO2000054309A1 (en) * | 1999-03-09 | 2000-09-14 | The Scripps Research Institute | Improved desorption/ionization of analytes from porous light-absorbing semiconductor |
| ATE365223T1 (de) | 1999-12-20 | 2007-07-15 | Penn State Res Found | Aufgebrachte dünne filme und ihr gebrauch in nachweis, anheftung und biomedizinischen anwendungen |
| US6696157B1 (en) | 2000-03-05 | 2004-02-24 | 3M Innovative Properties Company | Diamond-like glass thin films |
| US6641767B2 (en) | 2000-03-10 | 2003-11-04 | 3M Innovative Properties Company | Methods for replication, replicated articles, and replication tools |
| US6624839B2 (en) * | 2000-12-20 | 2003-09-23 | Polaroid Corporation | Integral organic light emitting diode printhead utilizing color filters |
| US20030010908A1 (en) * | 2001-07-02 | 2003-01-16 | Phillip Clark | Conductive card suitable as a MALDI-TOF target |
| ATE509272T1 (de) * | 2001-11-09 | 2011-05-15 | 3Dbiosurfaces Technologies Llc | Substrate mit hochliegendem oberflächenbereich für mikroarrays sowie verfahren zur herstellung davon |
-
2002
- 2002-11-18 US US10/299,962 patent/US7105809B2/en not_active Expired - Fee Related
-
2003
- 2003-10-07 JP JP2004553435A patent/JP2006506641A/ja not_active Withdrawn
- 2003-10-07 CN CNA2003801034240A patent/CN1711622A/zh active Pending
- 2003-10-07 AU AU2003279871A patent/AU2003279871A1/en not_active Abandoned
- 2003-10-07 KR KR1020057008731A patent/KR20050086664A/ko not_active Withdrawn
- 2003-10-07 CA CA002502919A patent/CA2502919A1/en not_active Abandoned
- 2003-10-07 WO PCT/US2003/031839 patent/WO2004047142A2/en not_active Ceased
- 2003-10-07 EP EP03773196A patent/EP1563525A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1563525A2 (en) | 2005-08-17 |
| WO2004047142A2 (en) | 2004-06-03 |
| CA2502919A1 (en) | 2004-06-03 |
| WO2004047142A3 (en) | 2005-02-17 |
| CN1711622A (zh) | 2005-12-21 |
| US20040094705A1 (en) | 2004-05-20 |
| US7105809B2 (en) | 2006-09-12 |
| AU2003279871A1 (en) | 2004-06-15 |
| JP2006506641A (ja) | 2006-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20050086664A (ko) | 미세구조화된 중합체성 기질 | |
| EP2973651B1 (en) | Preparation enhancements and methods of use for maldi mass spectrometry | |
| KR101448111B1 (ko) | 표면 증강 라만 분광용 기판 및 이의 제조방법 | |
| US20090069177A1 (en) | Laser desorption substrate | |
| KR20020022653A (ko) | 기체상 질량 분광계용 소수성 코팅을 구비한 샘플 홀더 | |
| KR101592517B1 (ko) | 레이저 탈착 이온화 질량 분석용 기판 및 그 제조방법 | |
| AT500618B1 (de) | Target für maldi/seldi-ms | |
| KR20170021398A (ko) | 말디톱 질량분석기에 이용가능한 시료 플레이트 및 상기 시료 플레이트의 제조방법 | |
| EP1726944A1 (en) | Sample target having surface-treated plane for holding sample and method for manufacture thereof, and mass spectrometer using the sample target | |
| JP4649416B2 (ja) | Ｍａｌｄｉ−ｔｏｆｍｓ用基板及びそれを用いた質量分析方法 | |
| US6958480B1 (en) | Sample desorption/ionization from mesoporous silica | |
| EP2684021B1 (en) | Improvements to matrix assisted laser desorption ionisation mass spectrometry imaging (maldi-msi) | |
| EP3418731B1 (en) | Sample mounting plate and method for manufacturing the same | |
| Noh et al. | Gold nanoislands chip for laser desorption/ionization (LDI) mass spectrometry | |
| US20060121599A1 (en) | Method for producing a sample carrier for maldi-mass spectrometry | |
| US20050279927A1 (en) | Use of ultraphobic surfaces having a multitude of hydrophilic areas for analyzing samples | |
| AT502134B1 (de) | Target für maldi/seldi-ms | |
| Li | Fundamental studies and bioanalytical applications of nanostructured-initiator mass spectrometry (NIMS) | |
| Qiao et al. | TECHNOLOGY REPORT |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20050516 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |