KR20050071375A - 조절성 방출 제형 내의 팽창성 삼투 조성물의 형성을 위한(삼투중합체, 삼투제를 포함하는) 코팅 현탁액 및 삼투코팅을 제공하기 위한 상응하는 방법 - Google Patents
조절성 방출 제형 내의 팽창성 삼투 조성물의 형성을 위한(삼투중합체, 삼투제를 포함하는) 코팅 현탁액 및 삼투코팅을 제공하기 위한 상응하는 방법 Download PDFInfo
- Publication number
- KR20050071375A KR20050071375A KR1020047021455A KR20047021455A KR20050071375A KR 20050071375 A KR20050071375 A KR 20050071375A KR 1020047021455 A KR1020047021455 A KR 1020047021455A KR 20047021455 A KR20047021455 A KR 20047021455A KR 20050071375 A KR20050071375 A KR 20050071375A
- Authority
- KR
- South Korea
- Prior art keywords
- osmopolymer
- coating
- film former
- coating suspension
- osmotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000576 coating method Methods 0.000 title claims abstract description 282
- 239000011248 coating agent Substances 0.000 title claims abstract description 274
- 239000000725 suspension Substances 0.000 title claims abstract description 193
- 230000003204 osmotic effect Effects 0.000 title claims abstract description 138
- 238000013270 controlled release Methods 0.000 title claims abstract description 41
- 239000000203 mixture Substances 0.000 title claims description 111
- 238000000034 method Methods 0.000 title claims description 84
- 239000002552 dosage form Substances 0.000 title abstract 3
- 238000001035 drying Methods 0.000 claims abstract description 8
- 239000002357 osmotic agent Substances 0.000 claims description 102
- 238000009472 formulation Methods 0.000 claims description 100
- 230000008569 process Effects 0.000 claims description 56
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 38
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 28
- 239000007787 solid Substances 0.000 claims description 26
- 239000002775 capsule Substances 0.000 claims description 25
- 239000002904 solvent Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000011780 sodium chloride Substances 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 13
- 229940079593 drug Drugs 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000003960 organic solvent Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 7
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 5
- 239000003125 aqueous solvent Substances 0.000 claims description 5
- 230000004888 barrier function Effects 0.000 claims description 5
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 229920000578 graft copolymer Polymers 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- -1 natrasol Polymers 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 9
- 239000007788 liquid Substances 0.000 description 24
- 238000005507 spraying Methods 0.000 description 22
- 239000000543 intermediate Substances 0.000 description 21
- 239000013583 drug formulation Substances 0.000 description 16
- 239000011877 solvent mixture Substances 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 239000000417 fungicide Substances 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 2
- 239000008199 coating composition Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 229920000875 Dissolving pulp Polymers 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 239000004614 Process Aid Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000012042 active reagent Substances 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000008376 breath freshener Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 238000010961 commercial manufacture process Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229940000033 dermatological agent Drugs 0.000 description 1
- 239000003241 dermatological agent Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 239000002373 plant growth inhibitor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Paper (AREA)
- Paints Or Removers (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39277502P | 2002-06-28 | 2002-06-28 | |
| US60/392,775 | 2002-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20050071375A true KR20050071375A (ko) | 2005-07-07 |
Family
ID=30000934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047021455A Withdrawn KR20050071375A (ko) | 2002-06-28 | 2003-06-28 | 조절성 방출 제형 내의 팽창성 삼투 조성물의 형성을 위한(삼투중합체, 삼투제를 포함하는) 코팅 현탁액 및 삼투코팅을 제공하기 위한 상응하는 방법 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7338663B2 (https=) |
| EP (1) | EP1528913A1 (https=) |
| JP (1) | JP2005532374A (https=) |
| KR (1) | KR20050071375A (https=) |
| CN (1) | CN1678292A (https=) |
| AR (1) | AR040301A1 (https=) |
| AU (1) | AU2003248868A1 (https=) |
| CA (1) | CA2490683A1 (https=) |
| IL (1) | IL165864A0 (https=) |
| MX (1) | MXPA05000207A (https=) |
| NO (1) | NO20050181L (https=) |
| NZ (1) | NZ537343A (https=) |
| TW (1) | TW200414900A (https=) |
| WO (1) | WO2004002450A1 (https=) |
| ZA (1) | ZA200500826B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6440457B1 (en) * | 1993-05-27 | 2002-08-27 | Alza Corporation | Method of administering antidepressant dosage form |
| ZA200711123B (en) | 2005-06-27 | 2009-08-26 | Biovail Lab Int Srl | Modified-release formulations of a bupropion salt |
| CA2655596C (en) * | 2006-06-27 | 2011-10-25 | Biovail Laboratories International Srl | Multiparticulate osmotic delivery system |
| US7538652B2 (en) * | 2006-08-29 | 2009-05-26 | International Business Machines Corporation | Electrical component tuned by conductive layer deletion |
| US20090004281A1 (en) * | 2007-06-26 | 2009-01-01 | Biovail Laboratories International S.R.L. | Multiparticulate osmotic delivery system |
| US20110052655A1 (en) * | 2007-08-08 | 2011-03-03 | Wilson Kurt Whitekettle | Methods and vesicles for controlling protozoa |
| US7824557B2 (en) * | 2007-08-08 | 2010-11-02 | General Electric Company | Method for controlling microbial biofilm in aqueous systems |
| US7785478B2 (en) * | 2007-08-08 | 2010-08-31 | General Electric Company | Method for controlling protozoa that harbor bacteria |
| US8784659B2 (en) * | 2007-08-08 | 2014-07-22 | General Electric Company | Method for controlling microbial biofilm in aqueous systems |
| CN102871982B (zh) | 2012-10-16 | 2014-09-10 | 中国科学院上海药物研究所 | 一种药物渗透泵制剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US36472A (en) * | 1862-09-16 | Cttlvebt | ||
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| US5324280A (en) | 1990-04-02 | 1994-06-28 | Alza Corporation | Osmotic dosage system for delivering a formulation comprising liquid carrier and drug |
| US5443459A (en) | 1991-01-30 | 1995-08-22 | Alza Corporation | Osmotic device for delayed delivery of agent |
| US5800422A (en) * | 1995-06-02 | 1998-09-01 | Alza Corporation | Osmotic device with delayed activation of drug delivery and complete drug release |
| PT1140012E (pt) * | 1998-12-17 | 2004-05-31 | Alza Corp | Conversao de capsulas de gelatina cheias com liquido em sistemas de libertacao controlada por camadas multiplas |
| US6352721B1 (en) | 2000-01-14 | 2002-03-05 | Osmotica Corp. | Combined diffusion/osmotic pumping drug delivery system |
-
2003
- 2003-06-27 TW TW92117738A patent/TW200414900A/zh unknown
- 2003-06-27 AR ARP030102341A patent/AR040301A1/es not_active Application Discontinuation
- 2003-06-28 KR KR1020047021455A patent/KR20050071375A/ko not_active Withdrawn
- 2003-06-28 CN CNA038206978A patent/CN1678292A/zh active Pending
- 2003-06-28 US US10/609,061 patent/US7338663B2/en not_active Expired - Lifetime
- 2003-06-28 JP JP2004518242A patent/JP2005532374A/ja not_active Withdrawn
- 2003-06-28 AU AU2003248868A patent/AU2003248868A1/en not_active Abandoned
- 2003-06-28 NZ NZ537343A patent/NZ537343A/en not_active IP Right Cessation
- 2003-06-28 IL IL16586403A patent/IL165864A0/xx unknown
- 2003-06-28 EP EP03762340A patent/EP1528913A1/en not_active Withdrawn
- 2003-06-28 MX MXPA05000207A patent/MXPA05000207A/es not_active Application Discontinuation
- 2003-06-28 CA CA002490683A patent/CA2490683A1/en not_active Abandoned
- 2003-06-28 WO PCT/US2003/021361 patent/WO2004002450A1/en not_active Ceased
-
2005
- 2005-01-12 NO NO20050181A patent/NO20050181L/no not_active Application Discontinuation
- 2005-01-27 ZA ZA200500826A patent/ZA200500826B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004002450A1 (en) | 2004-01-08 |
| EP1528913A1 (en) | 2005-05-11 |
| NZ537343A (en) | 2007-06-29 |
| US7338663B2 (en) | 2008-03-04 |
| CN1678292A (zh) | 2005-10-05 |
| IL165864A0 (en) | 2006-01-15 |
| CA2490683A1 (en) | 2004-01-08 |
| TW200414900A (https=) | 2004-08-16 |
| ZA200500826B (en) | 2006-08-30 |
| MXPA05000207A (es) | 2005-06-06 |
| AR040301A1 (es) | 2005-03-23 |
| AU2003248868A1 (en) | 2004-01-19 |
| JP2005532374A (ja) | 2005-10-27 |
| NO20050181L (no) | 2005-01-12 |
| US20040058002A1 (en) | 2004-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20041228 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |