KR20050058454A - 골관절염의 치료 방법 - Google Patents

골관절염의 치료 방법 Download PDF

Info

Publication number
KR20050058454A
KR20050058454A KR1020057003022A KR20057003022A KR20050058454A KR 20050058454 A KR20050058454 A KR 20050058454A KR 1020057003022 A KR1020057003022 A KR 1020057003022A KR 20057003022 A KR20057003022 A KR 20057003022A KR 20050058454 A KR20050058454 A KR 20050058454A
Authority
KR
South Korea
Prior art keywords
pain
dimethyl
substituted
methyl
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020057003022A
Other languages
English (en)
Korean (ko)
Inventor
요셉 안토니 코니셀리
케네쓰 스탠리 킬고어
드라고 로버트 슬리스코빅
수슨 엘리자베쓰 보브
데이비드 허버트 나이더퍼
마크 챨스 코알라
Original Assignee
워너-램버트 캄파니 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 워너-램버트 캄파니 엘엘씨 filed Critical 워너-램버트 캄파니 엘엘씨
Publication of KR20050058454A publication Critical patent/KR20050058454A/ko
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020057003022A 2002-08-22 2003-08-13 골관절염의 치료 방법 Ceased KR20050058454A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40525002P 2002-08-22 2002-08-22
US60/405,250 2002-08-22

Publications (1)

Publication Number Publication Date
KR20050058454A true KR20050058454A (ko) 2005-06-16

Family

ID=31946834

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057003022A Ceased KR20050058454A (ko) 2002-08-22 2003-08-13 골관절염의 치료 방법

Country Status (13)

Country Link
EP (1) EP1539127A1 (https=)
JP (1) JP2006501238A (https=)
KR (1) KR20050058454A (https=)
CN (1) CN1678297A (https=)
AU (1) AU2003255937A1 (https=)
BR (1) BR0313883A (https=)
CA (1) CA2494544A1 (https=)
IL (1) IL166600A0 (https=)
MX (1) MXPA05001254A (https=)
PL (1) PL375742A1 (https=)
TW (1) TW200410677A (https=)
WO (1) WO2004017952A1 (https=)
ZA (1) ZA200501133B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004105801A1 (en) * 2003-05-30 2004-12-09 Warner-Lambert Company Llc Animal model for the alleviation of pain using il-6
WO2005002557A1 (en) * 2003-07-03 2005-01-13 Warner-Lambert Company Llc Pharmaceutical compositions including an ether and selective cox-2 inhibitor and uses thereof
US20050026979A1 (en) * 2003-07-31 2005-02-03 Maha Ghazzi Methods for treating inflammation and inflammation-associated diseases with a statin and ether
DE102008000237A1 (de) 2007-02-06 2008-08-07 Basf Se Phenol-Imidazolderivate zur Stabilisierung von polymerisationsfähigen Verbindungen
IL181577A0 (en) * 2007-02-26 2007-07-04 Jacob Bar Tana Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders
US8530420B2 (en) * 2008-12-16 2013-09-10 Kaohsiung Medical University Treatment of arthritis with parathyroid hormone
TWI382841B (zh) 2010-10-29 2013-01-21 Univ China Medical 用於抑制發炎之醫藥組合物
CA3059073A1 (en) * 2017-04-18 2018-10-25 Gemphire Therapeutics Inc. Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor
JP2022505033A (ja) * 2018-10-18 2022-01-14 ジェムフィアー セラピューティクス インコーポレイテッド ゲムカベン、薬学的に許容されるその塩、その組成物、およびその使用方法
CN114847223B (zh) * 2022-02-19 2023-11-07 昆明理工大学 一种建立oa食蟹猴模型的方法
US12208085B2 (en) * 2022-05-31 2025-01-28 Ecuphar Nv Pyrazoline-derived compound for use in the prevention and/or treatment of pain and inflammation associated to surgery in mammals
CN118750511A (zh) * 2024-06-24 2024-10-11 中南大学湘雅医院 多元酸镁盐及其水合物在制备治疗或/和减缓关节疼痛的药物中的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
SK10622002A3 (sk) * 2000-01-25 2003-07-01 Warner-Lambert Company Étery dikarboxylátu vápenatého, metódy ich výroby a ich využitie na liečbu vaskulárnych chorôb a diabetu
US20030220374A1 (en) * 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors

Also Published As

Publication number Publication date
IL166600A0 (en) 2006-01-15
TW200410677A (en) 2004-07-01
CA2494544A1 (en) 2004-03-04
MXPA05001254A (es) 2005-06-08
CN1678297A (zh) 2005-10-05
BR0313883A (pt) 2005-07-19
WO2004017952A1 (en) 2004-03-04
PL375742A1 (en) 2005-12-12
ZA200501133B (en) 2008-01-30
AU2003255937A1 (en) 2004-03-11
JP2006501238A (ja) 2006-01-12
EP1539127A1 (en) 2005-06-15

Similar Documents

Publication Publication Date Title
US20070203212A1 (en) Method of treating osteoarthritis
KR20050058454A (ko) 골관절염의 치료 방법
TW201841637A (zh) 使用ccr3-抑制劑治療老化相關損傷之方法及組合物
RU2286151C2 (ru) Комбинации альфа-2-дельта-лиганда с селективным ингибитором циклооксигеназы-2
US20050026979A1 (en) Methods for treating inflammation and inflammation-associated diseases with a statin and ether
JP2026032031A (ja) グリコシダーゼインヒビターを含む医薬
WO2017168137A1 (en) Pyrimidobenzimidazoles for use in the treatment and prevention of neurodegenerative disorders
JP2005524618A (ja) シクロオキシゲナーゼ−2選択的阻害剤およびアスピリンの組み合わせを用いる、疼痛、炎症および炎症性疾患の治療
US20040034086A1 (en) Combination of an allosteric inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib
US20040034085A1 (en) Combination of an allosteric inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib
JP5575927B2 (ja) ペントキシフィリンの便秘の予防または治療における応用
US20030166706A1 (en) Method of treating osteoarthritis
JPWO2006118212A1 (ja) 膵炎の予防および治療剤
CN116650490A (zh) 化合物mt-1207在降低尿酸方面的应用
van Denderen et al. Efficacy and safety of mesalazine (Salofalk) in an open study of 20 patients with ankylosing spondylitis.
US20050004196A1 (en) Pharmaceutical compositions including an ether and selective COX-2 inhibitor and methods for using such
JP2006502991A (ja) マトリックスメタロプロテイナーゼ−13のアロステリックアルキン阻害剤とセレコキシブまたはバルデコキシブではないシクロオキシゲナーゼ−2の選択的阻害剤との組合せ物
WO2025077707A1 (zh) 用于自身免疫疾病治疗的s1pr4调节剂化合物及其应用
WO2024214791A1 (ja) リン酸化促進剤、結合阻害剤、及びそれらを用いた医薬組成物

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20050222

Patent event code: PA01051R01D

Comment text: International Patent Application

A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20050404

Comment text: Request for Examination of Application

PG1501 Laying open of application
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20060721

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20061228

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20060721

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I