KR20050032101A - 칼시토닌의 경구 투여 - Google Patents

칼시토닌의 경구 투여 Download PDF

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Publication number
KR20050032101A
KR20050032101A KR1020057001733A KR20057001733A KR20050032101A KR 20050032101 A KR20050032101 A KR 20050032101A KR 1020057001733 A KR1020057001733 A KR 1020057001733A KR 20057001733 A KR20057001733 A KR 20057001733A KR 20050032101 A KR20050032101 A KR 20050032101A
Authority
KR
South Korea
Prior art keywords
calcitonin
amount
oral
disodium salt
delivery agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020057001733A
Other languages
English (en)
Korean (ko)
Inventor
모이제 아츠리아
시몬 데이비드 베이트맨
제임스 에프. 맥레오드
Original Assignee
노파르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20050032101A publication Critical patent/KR20050032101A/ko
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020057001733A 2002-08-01 2003-07-31 칼시토닌의 경구 투여 Ceased KR20050032101A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40013902P 2002-08-01 2002-08-01
US60/400,139 2002-08-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020107029690A Division KR20110014690A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여

Publications (1)

Publication Number Publication Date
KR20050032101A true KR20050032101A (ko) 2005-04-06

Family

ID=31495795

Family Applications (6)

Application Number Title Priority Date Filing Date
KR1020057001733A Ceased KR20050032101A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여
KR1020127031292A Ceased KR20130004389A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여
KR1020177022695A Ceased KR20170097232A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여
KR1020167025673A Ceased KR20160113319A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여
KR1020147016376A Ceased KR20140084354A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여
KR1020107029690A Ceased KR20110014690A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여

Family Applications After (5)

Application Number Title Priority Date Filing Date
KR1020127031292A Ceased KR20130004389A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여
KR1020177022695A Ceased KR20170097232A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여
KR1020167025673A Ceased KR20160113319A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여
KR1020147016376A Ceased KR20140084354A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여
KR1020107029690A Ceased KR20110014690A (ko) 2002-08-01 2003-07-31 칼시토닌의 경구 투여

Country Status (19)

Country Link
US (2) US20060135402A1 (enExample)
EP (1) EP1526871A1 (enExample)
JP (4) JP2005535689A (enExample)
KR (6) KR20050032101A (enExample)
CN (1) CN1671418A (enExample)
AR (1) AR040737A1 (enExample)
AU (1) AU2003260346B2 (enExample)
BR (1) BR0313177A (enExample)
CA (1) CA2494212A1 (enExample)
IL (1) IL166337A (enExample)
MX (1) MXPA05001266A (enExample)
NO (1) NO20051023L (enExample)
NZ (1) NZ537944A (enExample)
PE (1) PE20040724A1 (enExample)
PL (1) PL373143A1 (enExample)
RU (1) RU2355417C2 (enExample)
TW (1) TWI307279B (enExample)
WO (1) WO2004012772A1 (enExample)
ZA (1) ZA200500516B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009508875A (ja) 2005-09-19 2009-03-05 エミスフェアー・テクノロジーズ・インク Ｎ−（５−クロロサリチロイル）−８−アミノカプリル酸二ナトリウム塩の結晶形
GB0522566D0 (en) 2005-11-04 2005-12-14 Novartis Ag Organic compounds
AU2008223108B2 (en) * 2007-03-02 2013-10-10 Novartis Ag Oral administration of a calcitonin
EP2185136A2 (en) * 2007-08-09 2010-05-19 Novartis Ag Oral calcitonin compositions and applications thereof
PL2215047T3 (pl) 2007-11-02 2014-05-30 Emisphere Tech Inc Sposób leczenia niedoborów witaminy b12
WO2011017346A2 (en) * 2009-08-03 2011-02-10 Emisphere Technologies, Inc. Fast-acting naproxen composition with reduced gastrointestinal effects
WO2012130193A1 (en) 2011-03-31 2012-10-04 Zentiva, K.S. Non-covalent soluble complexes of teriparatide with polysaccharides and a dosage form of teriparatide for oral administration
CN104095828A (zh) * 2014-07-29 2014-10-15 中国药科大学 一种降钙素口服肠溶组合物及其制备方法
CN113694190B (zh) 2015-02-09 2024-05-07 安特拉贝欧有限公司 骨质疏松症的治疗
CN104961687B (zh) * 2015-06-03 2017-07-25 苏州维泰生物技术有限公司 1,2‑二嗪衍生物及其制剂、用途
AU2017311698B2 (en) 2016-08-17 2024-09-05 Entera Bio Ltd. Formulations for oral administration of active agents
CR20230308A (es) 2020-12-11 2023-09-08 Civi Biopharma Inc Entrega oral de conjugados antisentido que tienen por blanco a pcsk9
PE20240640A1 (es) 2021-04-22 2024-04-04 Civi Biopharma Inc Administracion oral de oligonucleotidos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
AU4218400A (en) * 1999-04-05 2000-10-23 Emisphere Technologies, Inc. Lyophilized solid dosage forms and methods of making
CA2369591C (en) * 1999-04-05 2011-06-14 Emisphere Technologies, Inc. Disodium salts, monohydrate, and ethanol solvates
US7049283B2 (en) * 2000-12-06 2006-05-23 Novartis Ag Pharmaceutical compositions for the oral delivery of pharmacologically active agents

Also Published As

Publication number Publication date
KR20110014690A (ko) 2011-02-11
RU2005105691A (ru) 2006-01-20
MXPA05001266A (es) 2005-04-28
JP2016056190A (ja) 2016-04-21
JP5941035B2 (ja) 2016-06-29
NZ537944A (en) 2006-11-30
NO20051023L (no) 2005-04-27
US20060135402A1 (en) 2006-06-22
CA2494212A1 (en) 2004-02-12
WO2004012772A1 (en) 2004-02-12
RU2355417C2 (ru) 2009-05-20
JP2014062112A (ja) 2014-04-10
CN1671418A (zh) 2005-09-21
BR0313177A (pt) 2005-06-14
KR20160113319A (ko) 2016-09-28
US7569539B2 (en) 2009-08-04
TW200408409A (en) 2004-06-01
AU2003260346A1 (en) 2004-02-23
PE20040724A1 (es) 2004-12-06
JP2011026348A (ja) 2011-02-10
ZA200500516B (en) 2006-07-26
JP2005535689A (ja) 2005-11-24
KR20140084354A (ko) 2014-07-04
KR20130004389A (ko) 2013-01-09
US20070232524A1 (en) 2007-10-04
AR040737A1 (es) 2005-04-20
IL166337A0 (en) 2006-01-16
AU2003260346B2 (en) 2007-12-13
KR20170097232A (ko) 2017-08-25
TWI307279B (en) 2009-03-11
IL166337A (en) 2011-10-31
PL373143A1 (en) 2005-08-22
EP1526871A1 (en) 2005-05-04

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Patent event date: 20050131

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