KR20040064120A - Anti-bacterial body cleanser composition - Google Patents

Abstract

PURPOSE: Provided is an antibacterial body cleanser composition which exerts excellent antibacterial effect while reducing the amount of usage, and palliates or remedies skin diseases, such as eczema and itches, due to the bacteria together with the anti-inflammatory and deodorizing effects. CONSTITUTION: The antibacterial body cleanser composition comprises 0.01-2wt.% of 2,4,4-trichloro-2-hydroxy diphenylether expressed by formula 1, 0.01-2wt.% of 3,4,4-trichloro carbanylide expressed by formula 2, and 0.01-5wt.% of lavender extract. The composition is in a liquid phase.

Description

Anti-bacterial body cleanser composition

The present invention relates to an antibacterial body cleanser composition for imparting deodorant and anti-inflammatory effects to skin and improving skin diseases such as eczema. In more detail, the present invention provides bactericidal 2,4,4-trichloro-2-hydroxy diphenyl ether [trade name: Triclosan] and / or 3,4,4-trichloro carbanide [trade name: Triclo Caravan] is a composition containing lavender extract which is one of herb flavors, which is a natural antibacterial agent that can enhance sterilization, and improves skin deodorant anti-inflammatory effect and skin diseases such as eczema infected by bacteria and fungi. It relates to a liquid body cleanser composition characterized by

In general, the conditions for the antibacterial liquid body cleanser should be excellent in the amount and quantity of bubbles generated when using the body cleanser, smooth surface feel, excellent skin absorption, no skin irritation before and after use, high antibacterial activity for a long time and dry Should not break when done. In addition, the physical properties should be excellent.

In general, human skin is sebum in the sebaceous glands to break down the skin surface through the pores to suppress the evaporation of moisture of the skin to maintain elasticity. However, if the pores are blocked by abnormal keratinization of the skin epithelial cells, and sebum is not discharged to the skin surface, sebum is stuck in the pores, and when anaerobes are infiltrated, the skin becomes inflamed and reddened.

And even if sebum is well discharged on the surface of the skin, when time passes after washing, microorganisms in the air multiply on the surface of the skin and disperse the sebum, which makes the skin odor bad. There is some effect, but it is not complete. In order to suppress the occurrence of the odor of the skin in the United States, in particular US 4,282,111 attempted to remove the odor of the skin using a bactericidal triclosan, the prior literature reported that it is effective in the bactericidal test using triclocabon. However, all of these raw materials are chemically manufactured raw materials, which are not stable due to light, and thus have excellent skin deodorizing effect. However, they cannot be added to water soap (liquid body cleanser composition) due to the stability of triclocaban properties. Appeared.

Examples of such antibacterial agents used in liquid water soaps include triclosan, triclocaban, parachloromethaxylene (PCMX), dichlorophene, chlorohexidine salt, salicylic acid, etc., which are most excellent in antimicrobial activity. However, these substances are regulated by the domestic manor and the US FDA due to the stimulation and stability of the human body.

Therefore, the present inventors prepared a triclosan and triclocaban mixture in a liquid phase, which is excellent in disinfection and good penetration into the skin during the study to solve the problems of the prior art, and by using a combination of natural antibacterial agent, lavender, even if less other antibacterial agents are used. The present invention has been completed and found to be capable of producing a liquid body cleanser that can achieve synergistic effects and reduce or improve skin diseases such as eczema caused by bacteria and fungi, as well as deodorant and anti-inflammatory effects. .

Accordingly, an object of the present invention is to reduce the amount of antimicrobial agents by using synergistic effects of the appropriate combination of ingredients and to obtain an excellent antimicrobial effect, thereby reducing or reducing the skin diseases such as various eczema, itching caused by bacteria and fungi To improve. It is also an object of the present invention to obtain deodorizing and anti-inflammatory effects. Another object of the present invention is to provide a body cleanser composition containing triclosan and triclocaban while maintaining a stable liquid phase.

1A and 1B are photographs showing bacteria present in the body before washing with a body cleanser.

Figure 2a is a photograph showing the bacteria immediately after washing the body of Figure 1a with a conventional body cleanser, Figure 2b is a photograph showing the bacteria immediately after washing the body of Figure 1b with the composition according to the present invention.

3a and 3b are photographs showing the bacteria of the body after 2 hours after washing with a conventional body cleanser and the composition according to the present invention, respectively.

4a and 4b are photographs showing the bacteria of the body after 4 hours after washing with the conventional body cleanser and the composition according to the present invention, respectively.

In order to achieve the above object, the antibacterial body cleanser composition according to the present invention is 0.01 to 2% by weight of 2,4,4-trichloro-2-hydroxy diphenyl ether and 3,4, based on the total weight of the composition It is characterized by containing 0.01 to 2% by weight of 4-trichloro carbanide as an active ingredient.

Antibacterial body cleanser composition according to the present invention is characterized in that it further contains 0.01 to 5% by weight of the lavender extract as an active ingredient.

Antibacterial body cleanser composition according to the present invention is characterized in that the liquid.

Hereinafter, the present invention will be described in more detail.

The 2, 4, 4-trichloro-2-hydroxy diphenyl ether contained in the composition according to the present invention is commonly known as triclosan. The chemical formula of triclosan is as follows.

Triclosan of the above formula has an effect on bactericidal power and sebum removal. In particular, triclosan has excellent sterilization and antimicrobial activity against microorganisms such as pathogenic fungi, Escherichia coli, Staphylococcus aureus, which have excellent penetration and stability into skin and cause eczema and scabies caused by infection of skin or scalp. On the other hand, 3,4,4-trichloro carbanilide contained in the composition according to the present invention is commonly referred to as triclocaban, and its chemical formula is as follows.

Triclocaban of the above formula shows excellent bactericidal activity against fungal infection of the skin or scalp due to its excellent absorption and stability into the skin.

The term "lavender extract" referred to in the present invention includes not only the flower extract of lavender but also the active ingredient itself having an antibacterial function.

In the present invention, the lavender extract used as an active ingredient of antibacterial is particularly preferably obtained by steam distillation of lavender flowers. Lavender has a convergent, bactericidal and antibacterial effect, increases immune function, affects the function of each internal organ, glands or hormones, and increases resistance to bacteria, viruses and fungi.

Lavender contains essential oils in flowers, leaves, and stems, and the leaves become more fragrant and last longer. It has been used as a bathing agent since the Greek and Roman periods, and was used to smell the laundry in the Middle Ages. It is native to the Mediterranean coast and is a perennial plant of evergreen small trees. It grows to about 1m in size and blooms purple, purple, pink and white from June to August depending on the type. The plant has a violet rich scent that relaxes the mind throughout the plant, and once planted, has the advantage of being harvested and used continuously for 6-10 years.

When harvesting flowers, pick a sunny day before the buds open and cut the stems and dry them in a well-ventilated shade. The scientific name of lavender is Raven dulra (Lavandula sp.) As a, and the many variants of the 40 kinds of representative species are English lavender (Lavandula angustifolia), fringe de lavender (testosterone to Kass lavender) (L, Stoechas), Spike Lavender (L , latifolia ).

In the composition according to the present invention, the amount of 2,4,4-trichloro-2-hydroxy diphenyl ether is preferably 0.01 to 2% by weight based on the total weight of the composition. If it is less than 0.01% by weight, the effect is insignificant, and if it exceeds 2% by weight, there are problems of safety and formulation stability. In addition, it is preferable to contain 3,4,4-trichloro carbanide in an amount of 0.01 to 2% by weight, which is less than 0.01% by weight, and its effect is insignificant. On the other hand, the lavender extract is preferably contained in an amount of 0.01 to 5% by weight, if less than 0.01% by weight it is difficult to achieve the effect, if it exceeds 5% by weight problems in safety and product stability.

The composition of the liquid body cleanser formulation according to the present invention contains 10 to 30% by weight anionic surfactant, 5 to 20% by weight cationic surfactant, the anionic surfactant is sodium lauryl sulfate, sodium lauryl derived from palm oil Sodium salts of sulfonates and alkylbenzenesulfonates, sodium cocoyl isethionates, alkali salts of asar glutamate, and the like, and alkylbetaines and amidopropylbetaines may be used as cationic surfactants.

In addition, the composition according to the present invention further includes one or more of glycerin, propylene glycol, sorbitol, etc. to give skin moisturizing effect with natural oils, wax fatty alcohols, hydrocarbons, natural plant extracts, etc. to give the skin softening effect. It can further contain salicylic acid and citric acid as a sterilizing aid, titanium dioxide as an antioxidant and alkyl paraben as a preservative. In addition, it may further include a flavor, a dye, a metal ion blocking agent, these may be used that is commonly used.

The present inventors experimented as follows to demonstrate the efficacy of the composition according to the present invention.

<Test Example 1: Comparative test of the antimicrobial activity of triclosan, triclocaban, lavender extract>

Antibacterial activity is Streptococcus pyogenes 308A, Staphylococcus aureus SG 511, Escherichia coli DC O, Pseudomonas aeruginosa 9027, Salmonella Salmonella typhimurium , Klebsiella oxytoca 1082 E and Enterobacter cloacae 1321 E were measured. In order to measure the antimicrobial activity of triclosan, triclocaban, and lavender extract, the samples shown in Table 1 were inoculated with the agar dilution method, and then incubated for 48 hours in anaerobic condition at 37 ° C. The antimicrobial activity was measured as the minimum growth inhibition concentration (MIC) (ug / ml). The results are shown in Table 2 below.

Comparative Example 1 Comparative Example 2 Comparative Example 3 Experimental Example 1 Experimental Example 2 Experimental Example 3 Experimental Example 4 Experimental Example 5 Triclosan 5.0 mg - - 2.5 mg 1.67 mg 1.67 mg 1.67 mg 1.67 mg Tricrocarban - 5.0 mg - 2.5 mg 1.67 mg 1.67 mg 1.67 mg 1.67 mg Lavenda Extract - - 5.0 mg 1.67 mg 5.0 mg 7.5 mg 10.0 mg

Type of bacteria Comparative Example 1 Comparative Example 2 Comparative Example 3 Experimental Example 1 Experimental Example 2 Experimental Example 3 Experimental Example 4 Experimental Example 5 Streptococcus pyogenes 308A 1.0 0.1 1.0 0.5 0.3 0.2 0.1 0.1 Staphylococcus aureus SG 511 <0.01 10 10 <0.01 <0.01 <0.01 <0.01 <0.01 Escherichia coli DC O <0.01 > 100 100 <0.01 <0.01 <0.01 <0.01 <0.01 Pseudomonas aeruginosa 9027 100 100 100 100 10 10 10 1.0 Salmonella typhimurium (Salmonella typhimurium) <0.01 > 100 100 <0.01 <0.01 <0.01 <0.01 <0.01 Klebsiella oxytoca 1082 E <0.01 > 100 100 <0.01 <0.01 <0.01 <0.01 <0.01 Enterobacter cloacae 1321 E 0.1 100 10 0.08 0.01 <0.01 <0.01 <0.01

As shown in Table 2, when the same concentration of triclosan, triclocaban, and lavenda extracts respectively treated (control examples 1 to 3) than when treated with triclosan and triclocaban together (Experimental Example 1) It is more excellent, and compared to the antibacterial effect of the treatment with triclosan and triclocaban, it was found that the antibacterial effect when the Ravenda was further treated (Experimental Example 2) at the same concentration. On the other hand, it can be seen that the MIC decreases as the concentration of the lavender mixture increases (Experimental Examples 3 to 5).

The present inventors prepared the antibacterial body cleanser composition according to the present invention according to the composition of the following table.

Raw material name Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Example 1 Example 2 Cocamidopropyl Betaine 8.0 8.0 8.0 8.0 8.0 8.0 Polyquaternium-7 1.0 1.0 1.0 1.0 1.0 1.0 Disodium Ethylenediaminetetraacetic Acid 0.10 0.10 0.10 0.10 0.10 0.10 Propylene glycol 4.0 4.0 4.0 4.0 4.0 4.0 Methylglucoside dioleate 0.4 0.4 0.4 0.4 0.4 0.4 Allantoin 0.10 0.10 0.10 0.10 0.10 0.10 Sodium lauryloxyethylene sulfate 25.0 25.0 25.0 25.0 25.0 25.0 Cocaamide diethanolamine 0.30 0.30 0.30 0.30 0.30 0.30 Ethylene Glycol Stearate 0.40 0.40 0.40 0.40 0.40 0.40 Lauryl Sulfate Triethanolamine 15.0 15.0 15.0 15.0 15.0 15.0 Methylchloroisothiazolinone 0.05 0.05 0.05 0.05 0.05 0.05 Titanium dioxide 0.05 0.05 0.05 0.05 0.05 0.05 Sorbitol 2.0 2.0 2.0 2.0 2.0 2.0 Tocopherol 0.30 0.30 0.30 0.30 0.30 0.30 Salicylic acid 0.05 0.05 0.05 0.05 0.05 0.05 Triclosan - 1.0 - - 0.5 0.3 Tricloca-Avan - - 1.0 - 0.5 0.2 Lavenda Extract - - - 1.0 - 0.5 Purified water to 100 to 100 to 100 to 100 to 100 to 100

<Test Example 2: Observation of bacteria over time after washing>

In order to compare the antibacterial body cleanser composition according to the present invention prepared according to Example 2 with respect to conventional body cleanser and antibacterial activity, the composition of Example 2 and the general body cleanser, respectively, The number was observed.

1A and 1B are photographs of bacteria of the body before washing with a body cleanser. Figure 2a is taken of the bacteria present in the body immediately after washing with a normal body cleanser and Figure 2b is taken of the bacteria of the body immediately after washing with the antibacterial body cleanser composition according to the present invention. As a result, when washed with a general body cleanser, bacteria were not completely removed, but when washed with the antibacterial body cleanser composition according to the present invention, almost no bacteria could be found.

In addition, Figures 3a and 3b are taken of the body of the body at 2 hours after washing with a normal body cleanser and the composition according to the present invention, respectively. As a result, when washed with a general body cleanser, a significant amount of bacteria are present (Fig. 3a), when washed with the composition according to the present invention can be seen that almost no bacteria (Fig. 3b).

On the other hand, Figure 4a and Figure 4b is a photograph of the body of the body at the time after 4 hours after washing with a general body cleanser and the composition according to the present invention, respectively. 4 hours after washing, it can be seen that there are very many bacteria in the general body cleanser (FIG. 4a), but even after 4 hours of washing with the composition according to the present invention, almost no bacteria are still present. It can be seen that (Fig. 4b).

From the results, it can be seen that the composition according to the present invention significantly suppresses the number of bacteria that increase with time after washing.

In addition, the present inventors experimented as follows to prove that the antibacterial body cleanser composition according to the present invention is effective in skin itching and housewife eczema.

<Test Example 3: Skin itching effect>

30 men and women with skin itching from 5 to 40 years of age were used for 10 days, each of the body lens of Example 2 and the body lens of the comparative example, each 10 people according to the opinion of the user according to the following evaluation criteria It judged according to. The test results are shown in Table 4 below.

Very good skin itching effect: 5 points

Significant skin itching effect: 4 points

Slightly reduce skin itch: 3 points

No skin itching effect but no worsening: 2 points

No itching effect on skin but worsened: 1 point

division Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Example 1 Example 2 Skin itching effect 2.8 3.5 3.1 3.2 4.3 4.5

As shown in Table 4, the effect of reducing the skin itch is that it contains triclosan and triclocaban at the same time, rather than each containing triclosan, triclocaban, and lavender extract (Comparative Examples 2 to 4) (Example 1). ) Was more effective, and containing more of the lavender extract (Example 2) was the most effective.

<Test Example 4: skin eczema reduction effect>

Thirty men and women with skin eczema 20 to 60 years of age were used for 10 days each of the body and lens of the Examples and Comparative Examples for 10 days to determine the degree of effect according to the user's opinion according to the following evaluation criteria. The test results are shown in Table 5.

Very good skin eczema reduction effect: 5 points

Significant skin eczema reduction effect: 4 points

Slightly reduce skin eczema: 3 points

Does not reduce skin eczema but does not worsen: 2 points

There is no skin eczema reduction effect but rather worse: 1 point

division Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Example 1 Example 2 Housewife eczema reduction effect 2.1 3.5 3.2 3.6 4.3 4.8

As shown in Table 5, the skin eczema reduction effect was better in the case of Comparative Examples 2 to 4 added triclosan, triclocaban or Lavenda extract than Comparative Example 1 added only salicylic acid. In addition, the effect of Example 1 containing both triclosan and triclocaban at the same time was better than Comparative Examples 2 to 4, and in the case of Example 2 containing all of triclosan, triclocaban, and lavender extract, a synergy effect between the active ingredients occurred. Eczema reduction effect was the best.

Antibacterial body cleanser composition according to the present invention, by using the synergistic effect of the combination of the appropriate ingredients to reduce the amount of antimicrobial agent and to obtain an excellent antimicrobial effect, through which various eczema, itching and the like infected by bacteria and fungi Can reduce or ameliorate skin diseases. In addition, there is an effect that can be obtained deodorant and anti-inflammatory effect. In addition, there is an effect that can provide a body cleanser composition containing triclosan and triclocaban while maintaining a stable liquid.

Claims (3)

0.01 to 2% by weight of 2,4,4-trichloro-2-hydroxy diphenyl ether and 0.01 to 2% by weight of 3,4,4-trichlorocarbanide as active ingredients based on the total weight of the composition Antibacterial body cleanser composition. The antibacterial body cleanser composition of claim 1, further comprising 0.01 to 5% by weight of lavender extract as an active ingredient. The antibacterial body cleanser composition according to claim 1 or 2, wherein the composition is a liquid.