KR20040051766A - Composition for eliminating hangover - Google Patents

Abstract

PURPOSE: A composition for eliminating hangover is provided, thereby effectively removing alcohol without side-effects to human body, and eliminating hangover such as headache. CONSTITUTION: The composition for eliminating hangover comprises 40 to 90 wt.% of asparagus extract, 5 to 50 wt.% of two or more extracts selected from green tea extract, onion extract and Japanese apricot(maesil) extract, and 0.01 to 10 wt.% of two or more vitamins selected from vitamin A, vitamin B1, vitamin B2, vitamin C and vitamin B6. Alternatively, the composition for eliminating hangover comprises 40 to 90 wt.% of asparagus extract, 5 to 40 wt.% of green tea extract, 0.1 to 10 wt.% of onion extract, 0.01 to 3 wt.% of vitamin B1, 0.01 to 3 wt.% of vitamin B2 and 0.01 to 4 wt.% of vitamin C.

Description

Composition for eliminating hangovers {Composition for eliminating hangover}

The present invention relates to a composition for relieving hangover, more specifically 40 to 90% by weight of asparagus extract, 5 to 50% by weight of two or more extracts selected from the group consisting of green tea extract, onion extract and plum extract, and vitamin A It relates to a hangover relief composition consisting of 0.01 to 10% by weight of two or more vitamins selected from the group consisting of, vitamin B1, vitamin B2, vitamin C and vitamin B6.

Drinking is becoming a necessity for modern people who have frequent drinking and entertainment and are stressful, and the drinking opportunities are increasing day by day. Excessive drinking temporarily causes hangovers such as palpitations, headaches, thirst, motion sickness, gastrointestinal disorders, and diarrhea, and chronically can cause diseases such as fatty liver and cirrhosis. The headache of the hangover is due to the expansion of the brain vessels, thirst and dehydration is due to the diuretic action of ethanol produced by inhibiting the secretion of vasopressin, an antidiuretic hormone secreted by ethanol from the pituitary gland. In addition, gastrointestinal disorders such as gastrointestinal disorders are due to increased gastric acid secretion. As described above, the causes of hangover are various, but the biggest cause is caused by the poisoning effect of ethanol or acetaldehyde accumulated in hepatocytes.

Ethanol degradation in the liver is the metabolism of the conversion of acetaldehyde through oxidation. The metabolism is known to be driven by three reactive enzyme systems: alcohol dehydrogenase, microsomal ethanol-oxidizing system (MEOS) and catalase (K. Ebihara et al ., Agri) . Biol. Chem. , 52: 1311, 1988). In addition to the decomposition mechanism of ethanol as well as the toxicological studies of ethanol have been made in various ways, it has been reported that the toxicity of ethanol is not only observed neurologically but also genetically (J. Caballeria, et al. , Life Sci ., 41: 1021-1727, 1986). Recently, research and experiments have been conducted on a number of substances that can reduce the toxicity of ethanol or inhibit the expression of toxic substances. As a result, various dietary supplements containing ingredients extracted from natural foods or herbal medicines are related. (Jeong-Han Kim, et al . , 38 (6): 549-553, 1995).

As part of such research, a composition using choline acids, which have an effect of edema, hepatic detoxification, hepatic blood flow improvement, promotion of fat absorption, and excretion of waste products through micro-disease, is commercially available. Examples include ursodeoxycholic acid, which is known to be effective in improving liver function of liver disease, systemic malaise due to liver dysfunction, indigestion, anorexia, physical fatigue, and the like; Tauroursodeoxycholic acid, which is commercially available as a gallstone dissolving agent and is effective in treating fatty liver, which has an effect of improving liver function and reducing liver fat during oral administration; Chenodeoxycholic acid sold as a gallstone dissolving agent; And dehydrocholic acid. However, the composition using choline acids is effective in the general symptoms caused by stress, such as increase of adrenal weight by stress and prevention of spleen atrophy, suppression of ascorbic acid content change of adrenal gland and suppression of blood biochemical changes. It is proven, and there are no reports on the effects of relieving hangovers or protecting the liver.

In addition, as a herbal or folk remedy, various types of medicines have been developed, which are mainly composed of ingredients such as ginseng and thorny ginseng, which are known to be useful in relieving hangovers. Among them, a number of nourishing tonic drinks are mainly marketed as ginseng, and various ingredients such as honey and vitamins are also marketed as nourishing tonic. Brekhman et al ., Lloydia , 32 (1): 46-51, 1969), Ocimum sanctum Linn, tinosporamalabarica (Sen, P., Maiti, PC and Ray) , A. Indian J. Exp. Biol. , 30: 592-596, 1992), although herbal medicines such as melatonin and other biological substances have been reported to exhibit hangover relief, but some of the various hangover symptoms caused by drinking are reported. It was found to be effective only for symptoms or to minimize hangover relief. Recently, products containing plant extracts mainly containing soybean sprouts and products containing embryonic and soybean extracts have been introduced. However, they also point out a number of problems that still need to be addressed in terms of the stability of the formulation.

As such, a drink containing various herbal medicines is commercially available for removing the hangover after drinking. These drinks are used alone after drinking, and in addition to alcohol with high alcohol content before drinking. However, a drink containing some herbal medicines may not only cause systemic boredom, bloating, vomiting or abdominal pain, but also some drink may be sold at high prices by using expensive herbal medicines.

Therefore, the inventors of the present invention while continuing to develop a new hangover composition having excellent efficacy for the overall hangover relief caused by drinking without side effects on the human body, the group consisting of green tea extract, onion extract and plum extract in asparagus extract The present invention was completed by confirming that the composition of two or more kinds of extracts selected from and a small amount of vitamins exhibited an excellent hangover effect without adverse effects on the human body.

Accordingly, it is an object of the present invention to provide a hangover relief composition having excellent hangover relief and alcohol decomposition efficacy without side effects on the human body.

In addition, another object of the present invention to provide a hangover drink containing the composition.

Still another object of the present invention is to provide a hangover gum comprising the composition.

1 is a graph showing the change in blood alcohol concentration after taking the hangover relief composition according to the present invention.

-●-: Hangover composition according to the present invention

-■-: Asparagus Extract

-▲-: C products

Figure 2 is a graph showing the change in blood alcohol concentration according to the preparation form after taking the hangover relief composition of the present invention.

-◆-: Gum

-■-: drink

-▲-: drink + gum

In order to achieve the above object, the present invention 40 to 90% by weight asparagus extract, 5 to 50% by weight of two or more extracts selected from the group consisting of green tea extract, onion extract and plum extract, and vitamin A, vitamin B1 To provide a hangover relief composition consisting of 0.01 to 10% by weight of two or more vitamins selected from the group consisting of, vitamin B2, vitamin C and vitamin B6.

In addition, in order to achieve another object of the present invention, the present invention provides a hangover drink comprising the composition.

In order to achieve another object of the present invention, the present invention provides a hangover gum comprising the composition.

Hereinafter, the present invention will be described in detail.

The present invention is characterized by providing a hangover relief composition having an excellent synergistic effect by adding an extract of another plant to the asparagus extract. Hangover composition according to the present invention contains asparagus extract as a main component. Asparagus comes in two varieties: green asparagus and white asparagus, which differ somewhat in nutritional value. Asparagus contains a large amount of alkaloids such as asparagin and asparaginic acid as special ingredients, as well as minerals such as calcium, phosphorus and potassium, and vitamins A, B1, B2 and C. Asparagine, the main ingredient of asparagus, is known to be effective for neuralgia and rheumatism caused by uric acid accumulation by helping the kidneys to function, promote uric acid excretion, and destroy oxalic acid (oxalic acid) crystals in the kidneys and entire muscle system. Asparagus is an edible and medicinal vegetable species that has been used since ancient times as its root, diuretic and sedative. In particular, green asparagus works to make the liver move better and to cool the body. Asparagus extract used in the present invention is more preferably prepared from green asparagus. Hangover composition according to the invention preferably comprises 40 to 90% by weight of asparagus extract based on the total weight of the composition. If the content of the asparagus extract is less than 40% by weight can not expect a sufficient hangover effect, on the contrary, if the amount exceeds 90% by weight hangover removal effect is increased, but the taste is not harmonized with other extracts.

In addition, the hangover composition according to the invention comprises at least two extracts selected from the group consisting of green tea extract, onion extract and plum extract in addition to the asparagus extract.

Green tea is known to clear skin and have anti-aging effects. In addition, green tea contains a large amount of catechin and ECGC ( e pi- g allo c atechin g allate), which are known to have antioxidant, anti-cancer and cholesterol inhibitory effects. The green tea extract used in the hangover composition according to the present invention is preferably an extract having a catechin content of 30% or more, in particular, a green tea extract having an ECGC content of 10% or more.

Onion physiologically promote the secretion of digestive juices and has the effect of excitement, sweating and diuresis. This is because of compounds such as propyl disulfide and allyl sulfide present in onions. Onion contains various vitamins and minerals such as calcium and phosphate to remove harmful substances in the blood. In addition, onions are known to contain a large amount of derivatives of glutathione (glutathione) to enhance the detoxification function of the liver.

Plums are the fruits of plum trees, rich in minerals, vitamins, organic acids (citric acid, apple acids, succinic acid, and tartaric acid), and also contain carotene and minerals such as calcium, phosphorus, and potassium. Plum is an alkaline food, good for fatigue recovery and constitution improvement. Especially, it has excellent detoxification and helps to treat upset stomach and food poisoning. In addition, the sour taste of plum is known to secrete gastric juice and normalize the digestive system to eliminate indigestion and gastrointestinal disorders.

Hangover composition according to the present invention preferably contains 5 to 50% by weight of two or more extracts selected from green tea extract, onion extract and plum extract (plum extract). In particular, it is most preferable to include the green tea extract and onion extract or green tea extract and plum extract selected from the three extracts. At this time, if the mixture of green tea extract and onion extract or green tea extract and plum extract is less than 5% by weight, the hangover removal effect is insignificant. do. In particular, the green tea extract and onion extract is preferably contained in 5 to 40% by weight and 0.1 to 10% by weight relative to the total weight of the composition, respectively, the green tea extract and plum extract is 5 to 40% by weight and 0.1 to the total weight of the composition It is preferably included in 10% by weight.

Asparagus extract, green tea extract, onion extract and plum extract included in the hangover composition according to the present invention may be prepared by methods known in the art. Specifically, in the present invention, after washing the whole plant, leaves or berries cleanly and finely cut, soaked in water and first extracted for 120 to 300 minutes at 85 to 110 ℃, then add water again according to the same conditions 2 Tea extracted. Then, the extract was filtered to discard the residue, and then the supernatant was concentrated by heating. The concentrated extract as such may be stored at 4 ° C. until use, or may be prepared in powder form by spray drying or lyophilization. At this time, the dried powder sample should be kept in a state where water absorption is suppressed.

In addition, the hangover composition according to the present invention contains a small amount of vitamins. As the vitamin, two or more kinds selected from the group consisting of vitamin A, vitamin B1, vitamin B2, vitamin C and vitamin B6 may be used. At this time, the vitamin is preferably contained in 0.01 to 10% by weight based on the total weight of the composition, in particular vitamins B1, B2 and C are 0.01 to 3% by weight, 0.01 to 3% by weight and 0.01 to 4, respectively, relative to the total weight of the composition Most preferably included in weight percent.

Examples of hangover relief compositions that may be prepared according to the present invention are shown in Tables 1 and 2 below. However, the hangover composition according to the present invention is not limited to the following.

Hangover composition 1 according to the invention Content (% by weight) Asparagus Extract 40-90 Green tea extract 5-40 Onion extract 0.1-10 Vitamin B1, B2 and C 0.01-10

Hangover composition 2 according to the invention Content (% by weight) Asparagus Extract 40-90 Green tea extract 5-40 Plum Extract 0.1-10 Vitamin B1, B2 and C 0.01-10

The present invention provides a hangover drink comprising a composition for releasing hangover according to the present invention. The beverage may be prepared by adding the components commonly used in hangover relief compositions and beverage compositions according to the present invention, such as amino acids, sweeteners, flavoring, citric acid, sodium bicarbonate, salts and the like. In this case, as the amino acid, it is preferable to use an amino acid having a neurotransmitter effect in the body such as glycine, tyrosine, glutamic acid, phenylalanine, and alanine. Oligosaccharides, fructose, glucose, dextrin and fructooligosaccharides may be used as the sweetener. In addition, a small amount of carbon dioxide may be injected and prepared according to the preference of the drinker. The hangover beverage according to the present invention preferably contains 0.1-20w / v%, more preferably 0.1-5w / v% of the hangover composition based on the total weight.

In addition, the present invention provides a hangover gum comprising the composition for hangover releasing according to the present invention. The hangover gum is a conventional hangover known in the art by adding the common ingredients necessary for the preparation of the gum, such as gum base and sugar, glucose, isomalt or xylitol to the hangover composition according to the invention It may be prepared according to the method. In addition, in order to soften the physical properties of the gums and to aggregate the gums well, sugar syrups such as sorbitol 80, syrup, maltitol syrup or sorbitol syrup may be added. In addition, one or more selected from the group consisting of fragrances, stabilizers, colorants, emulsifiers and brighteners may be further added and prepared. The fragrance is added to improve the fragrance of the gum, it may be used a mint, fruit or herb flavor. As the stabilizer, gum arabic, gelatin or carageenan may be used. Due to the addition of such stabilizers, it is possible to maintain the freshness and preserve the shape with respect to changes during heating or preservation during processing, and to improve the texture and feel of the gum. In addition, the hangover gum according to the present invention may be prepared by further adding a natural or synthetic coloring such as gardenia blue pigment, gardenia yellow pigment, caramel pigment or grape skin extract pigment to enhance the visual effect. Furthermore, in order to evenly disperse the fragrance in the sugar solution, an emulsifier such as sucrose fatty acid ester or lecithin and a polishing agent such as carnauba wax or shellac are added to increase the visual effect of the gum. Can be. Hangover gum according to the present invention preferably contains 50-500mg, more preferably 150mg hangover composition according to the present invention per 1.6g gum.

Hangover composition according to the invention can be used in various formulations, such as suspensions, pills, tablets, capsules, powders and the like convenient to take in addition to the beverage and gum. Such formulations may be prepared using conventional methods known in the art.

Hereinafter, the present invention will be described in detail by way of examples. However, the following examples are merely to illustrate the invention, but the content of the present invention is not limited to the following examples.

<Example 1>

Preparation of hangover relief composition

The present inventors prepared a composition for releasing hangover by adding onion extract and vitamin to increase the hangover relief effect in the asparagus extract and green tea extract as having a high blood alcohol reducing effect in the result of Reference Example 2. The composition ratio of each component is shown in Table 3 below.

Component and content of hangover composition according to the present invention ingredient Content (% by weight) Asparagus Extract 87.0 Green tea extract 10.0 Onion extract 2.0 Vitamin B1 0.25 Vitamin B2 0.25 Vitamin c 0.5 total 100

Experimental Example 1

Investigation of hangover effect of hangover composition according to the present invention

In order to measure the hangover relief effect of the composition for hangover relief prepared in Example 1, experiments were conducted on 18 healthy men and women over 20 years old. Specific characteristics of clinical trial subjects are listed in Table 4 below.

Test subject Age (years) 22.94 ± 2.05 Gender Male Female) 2: 1 Body weight (kg) 67.12 ± 12.94

The subjects were asked to eat one Vienna sausage per glass of soju and consume 300ml of soju for 20 minutes. After 10 minutes, 150 mg of the hangover composition prepared in Example 1 was dissolved in 15 ml of bottled water. At this time, the control group was to take 150mg of asparagus extract dissolved in 15ml of bottled water, 15ml of bottled water, and 75ml of C drink on the market. Then, blood alcohol levels were measured from 30 minutes to 90 minutes immediately after drinking. At this time, the blood alcohol concentration was measured using a breathalyzer to measure the blood concentration in expiratory air. As a result, as shown in Figure 1, when taking the hangover relief composition according to the present invention was very excellent in blood alcohol reduction rate compared to the case of taking only asparagus extract, after 90 minutes are sold in the market It was confirmed that the alcohol concentration was about 10% lower than when taking the C product.

In addition, to evaluate the subjective symptoms, a clinical questionnaire was performed the day after drinking. The questionnaire was completed on a scale of 5 steps (1-5) with a minimum of 1 and a maximum of 5 for no effect on the hangover, digestive and headache reduction effects. At this time, the hangover removal effect was investigated for symptoms of nausea, tinnitus, vomiting and thirst, and the digestive effect was investigated for symptoms of intestinal dysfunction such as diarrhea. As a result, as shown in Table 5, it was confirmed that the case of taking the composition according to the present invention showed the highest hangover effect, in particular, it was confirmed that showed a significantly better hangover effect than asparagus extract alone. In Table 5 below, the numerical values for each item are average values for the numerical values of 1 to 5 described by the test subjects.

Clinical Survey Results for Hangover Relief Effect after Taking Hangover Relief Composition of the Present Invention Formulation Test substance (number of people) Survey Average Hangover removal effect Digestive effect Headache Reduction Effect beverage Hangover composition of the present invention (18 people) 4.13 3.67 3.80 Asparagus Extract (18 persons) 3.86 3.14 3.57 Bottled water (18 people) 2.00 1.79 2.00 C products (9 people) 2.71 2.14 2.43

<Example 2>

Chewing gum comprising the hangover composition of the present invention as an active ingredient

Hang chewing gum was prepared according to a conventional method known in the art so that each one chewing gum contains 150mg of the hangover composition prepared in Example 1 above. Specific components and contents are shown in Table 6 below.

Component and content of hangover gum according to the present invention ingredient content (%) Xylitol 60.867 Isomalt 11.055 Gum base 19.770 Hangover composition according to the invention 3.350 Maltitol syrup 2.010 Sword arabic 1.220 Spices 1.310 Polish 0.300 Pigment 0.106 Emulsifier 0.012 total 100

Experimental Example 2

Investigation of hangover relief effect of hangover gum according to the present invention

The test subjects described in Table 4 were given one Vienna sausage per glass of soju to ingest 300 ml of soju for 20 minutes. After 10 minutes, the hangover chewing gum prepared in Example 2 was allowed to chew for 10 minutes. As a control, the X product (gum) was chewed. Thereafter, blood alcohol levels were measured using a breathalyzer for 90 minutes at 30 minutes intervals immediately after drinking. In this case, the blood alcohol concentration was 100% alcohol concentration immediately after drinking, and the remaining alcohol concentration was expressed as%. As a result, as shown in Table 7, it was confirmed that the blood alcohol concentration was reduced compared to the control when taking hangover gum according to the present invention.

Blood alcohol residual measurement result after taking hangover gum of the present invention Immediately after drinking 30 minutes later 60 minutes later 90 minutes later Hangover gum according to the present invention 100% 82.7% 73.8% 63.9% Control (X Products) 100% 85.3% 78.3% 69.6%

In addition, according to the same method as Experimental Example 1 was carried out a clinical questionnaire for the hangover removal effect, digestive effect and headache reduction effect. As a result, as shown in Table 8, when taking the hangover gum according to the invention it was confirmed that the hangover removal effect is superior to the control.

Clinical Survey Results of Hangover Relief after Drinking Chewing Gum of the Present Invention Formulation Test substance (number of people) Survey Average Hangover removal effect Digestive effect Headache Reduction Effect chewing gum Hangover composition of the present invention (18 people) 3.77 2.62 4.00 X products (18 people) 3.20 2.80 2.47

Experimental Example 3

Hangover relief effect according to the formulation of the hangover relief composition of the present invention

The inventors of the present invention, in order to find out the hangover effect according to the preparation form of the hangover relief composition according to the present invention, 1) when taken as a drink, 2) when taken as a gum, and 3) after taking as a drink In addition, it was divided into the case of taking gum again and investigated. Blood alcohol concentration was measured according to the same method as Experimental Example 1. The results are shown in Table 9 and FIG. 2. In addition, a questionnaire on the hangover relief effect was examined in the same way as Experimental Example 1 for each experimental group the next day after drinking. The results are shown in Table 10 below.

Blood alcohol residual measurement after taking hangover composition of each formulation Formulation Immediately after drinking 30 minutes later 60 minutes later 90 minutes later chewing gum 100% 82.7% 73.8% 63.9% beverage 100% 76.9% 69.3% 60.8% Drink + Gum 100% 81.6% 69.9% 60.2%

As shown in Table 9 above, after taking the beverage, the rate of decrease in blood alcohol concentration was higher than that in the case of taking the gum, but at a time after 60 minutes to 90 minutes, the constant rate of reduction was maintained for 90 minutes. Later, the level was similar to the blood alcohol level when the gum was taken. In addition, when taken together with the drink and gum, there was no clear synergistic effect of blood alcohol concentration. However, as shown in the following Table 10, the survey on the hangover relief obtained a much higher evaluation.

Clinical Survey Results of Hangover Relief after Taking Hangover Relief Compositions Formulation form (number of people) Survey Average Hangover removal effect Digestive effect Headache Reduction Effect Drinks (18 people) 4.13 3.67 3.80 Gum (18 people) 3.77 2.62 4.00 Drinks + Gum (18 People) 4.44 3.67 4.44

From the above results, it can be seen that even when the hangover composition according to the present invention is taken as a gum rather than a beverage, the hangover effect can be exhibited. In addition, the hangover gum according to the present invention can be seen that the usefulness of the hangover removal solution according to the present invention is commercialized as a drink.

Experimental Example 4

Acute toxicity test of hangover composition according to the present invention

First, the hangover composition prepared in Example 1 was prepared at concentrations of 1 g / ml, 0.5 g / ml, 0.25 g / ml and 0.125 g / ml. Forty four ICR male mice (20-24 g body weight) fasted for 24 hours prior to the experiment were divided into four equal groups, and then 1 ml of hangover composition for each 20 g body weight of the mouse was administered using oral administration sonde. Was administered orally. Thereafter, mice were observed for 9 days. The results are shown in Table 11 below.

Acute Toxicity Test Results 1 g / ml 0.5 g / ml 0.25g / ml 0.125 g / ml Abnormal symptoms none none none none Death / experiment 0/10 0/10 0/10 0/10

As shown in Table 11, no death was observed after administration of the hangover composition according to the present invention, and all the mice were in good health when visually observed. In addition, all activities of the mice were normal except for a slight increase in body weight. After 9 days, each mouse was dissected to examine each tissue and organ, and no abnormalities were found in all tissues and organs. From this it can be seen that the composition for hangover relief according to the present invention is safe for human body.

As described above, the present inventors confirmed that the composition for relieving hangover according to the present invention is excellent in reducing alcohol while having no side effects on the human body, and having an excellent hangover relief effect such as headache and nausea. The hangover composition according to the present invention is commercialized as a beverage and gum containing the same as an active ingredient can be useful and convenient to relieve hangover after drinking modern people.

Claims (5)

40 to 90% by weight of asparagus extract, 5 to 50% by weight of two or more extracts selected from the group consisting of green tea extract, onion extract and plum extract, and a group consisting of vitamin A, vitamin B1, vitamin B2, vitamin C and vitamin B6 Hangover cure composition consisting of 0.01 to 10% by weight of two or more vitamins selected from. According to claim 1, Asparagus extract 40 to 90%, green tea extract 5 to 40% by weight, onion extract 0.1 to 10% by weight, vitamin B1 0.01 to 3% by weight, vitamin B2 0.01 to 3% by weight and vitamin C 0.01 to Hangover composition, characterized in that consisting of 4% by weight. The method of claim 1, wherein the asparagus extract 40 to 90% by weight, green tea extract 5 to 40% by weight, plum extract 0.1 to 10% by weight, vitamin B1 0.01 to 3% by weight, vitamin B2 0.01 to 3% by weight and vitamin C 0.01 to Hangover composition, characterized in that consisting of 4% by weight. Hangover drink containing the composition of any one of claims 1 to 3. Hangover gum comprising the composition of any one of claims 1 to 3 and the gum base.