KR20030083015A - Ｃｃｒ5 길항제로서 유용한 아릴 옥심-피페라진 - Google Patents
Ｃｃｒ5 길항제로서 유용한 아릴 옥심-피페라진 Download PDFInfo
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- KR20030083015A KR20030083015A KR10-2003-7012566A KR20037012566A KR20030083015A KR 20030083015 A KR20030083015 A KR 20030083015A KR 20037012566 A KR20037012566 A KR 20037012566A KR 20030083015 A KR20030083015 A KR 20030083015A
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- IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 description 1
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- 125000006239 protecting group Chemical group 0.000 description 1
- 239000002212 purine nucleoside Substances 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
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- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
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- 229940063627 rescriptor Drugs 0.000 description 1
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- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27995001P | 2001-03-29 | 2001-03-29 | |
| US60/279,950 | 2001-03-29 | ||
| PCT/US2002/009490 WO2002079157A1 (en) | 2001-03-29 | 2002-03-27 | Aryl oxime-piperazines useful as ccr5 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20030083015A true KR20030083015A (ko) | 2003-10-23 |
Family
ID=23071025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2003-7012566A Withdrawn KR20030083015A (ko) | 2001-03-29 | 2002-03-27 | Ｃｃｒ5 길항제로서 유용한 아릴 옥심-피페라진 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6689783B2 (https=) |
| EP (1) | EP1373206B1 (https=) |
| JP (1) | JP4303969B2 (https=) |
| KR (1) | KR20030083015A (https=) |
| CN (1) | CN1253435C (https=) |
| AR (1) | AR033622A1 (https=) |
| AT (1) | ATE418542T1 (https=) |
| AU (1) | AU2002303168B2 (https=) |
| CA (1) | CA2442210C (https=) |
| DE (1) | DE60230491D1 (https=) |
| ES (1) | ES2318009T3 (https=) |
| HU (1) | HUP0400389A3 (https=) |
| IL (1) | IL157713A0 (https=) |
| MX (1) | MXPA03008801A (https=) |
| MY (1) | MY134019A (https=) |
| NZ (1) | NZ528011A (https=) |
| WO (1) | WO2002079157A1 (https=) |
| ZA (1) | ZA200307171B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7825121B2 (en) * | 1999-05-04 | 2010-11-02 | Schering Corporation | Piperazine derivatives useful as CCR5 antagonists |
| PE20040769A1 (es) * | 2002-12-18 | 2004-11-06 | Schering Corp | Derivados de piperidina utiles como antagonisas ccr5 |
| EP1725235B1 (en) * | 2004-02-05 | 2009-04-15 | Schering Corporation | Piperidine derivatives useful as ccr3 antagonists |
| BRPI0509803A (pt) | 2004-04-13 | 2007-09-18 | Incyte Corp | derivados de piperazinilpiperidina como antagonistas de receptor de quimiocina |
| US20070215685A1 (en) * | 2005-02-03 | 2007-09-20 | Yottamark, Inc. | System and Method of Product Identification Using a URL |
| JP4769257B2 (ja) * | 2005-02-23 | 2011-09-07 | シェーリング コーポレイション | ケモカインレセプターのインヒビターとして有用なピペリジニルピペラジン誘導体 |
| US20080108586A1 (en) * | 2006-09-06 | 2008-05-08 | Incyte Corporation | Combination therapy for human immunodeficiency virus infection |
| KR100830003B1 (ko) * | 2006-10-31 | 2008-05-15 | 씨제이제일제당 (주) | 결정성 ｓ-(-)-암로디핀 아디핀산 염 무수물 및 이의 제조방법 |
| US20080173808A1 (en) * | 2007-01-18 | 2008-07-24 | Schering Corporation | Process and device for response normalized liquid chromatography nanospray ionization mass spectrometry (rnlc-nsi-ms) |
| EP2741777B1 (en) | 2011-08-12 | 2017-01-18 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
| AU2021222441A1 (en) | 2020-02-19 | 2022-09-22 | Ichilov Tech Ltd. | Improved antidepressant therapy |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
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| US4949314A (en) | 1966-08-16 | 1990-08-14 | The United States Of America As Represented By The Secretary Of The Navy | Method and means for increasing echo-ranging-search rate |
| US4211771A (en) | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| GB8327880D0 (en) | 1983-10-18 | 1983-11-16 | Ajinomoto Kk | Saccharomyces cerevisiae |
| US4569790A (en) | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
| US4604377A (en) | 1984-03-28 | 1986-08-05 | Cetus Corporation | Pharmaceutical compositions of microbially produced interleukin-2 |
| US4530787A (en) | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
| IL76360A0 (en) | 1984-09-26 | 1986-01-31 | Takeda Chemical Industries Ltd | Mutual separation of proteins |
| US4748234A (en) | 1985-06-26 | 1988-05-31 | Cetus Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
| NZ230045A (en) * | 1988-08-05 | 1990-11-27 | Janssen Pharmaceutica Nv | 3-piperazinylbenzazole derivatives and pharmaceutical compositions |
| US5368854A (en) | 1992-08-20 | 1994-11-29 | Schering Corporation | Use of IL-10 to treat inflammatory bowel disease |
| US5464933A (en) | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
| AU4788396A (en) | 1995-02-16 | 1996-09-04 | Children's Medical Center Corporation | Inhibition of angiogenesis using interleukin-12 |
| CA2371583C (en) * | 1999-05-04 | 2005-09-13 | Schering Corporation | Piperazine derivatives useful as ccr5 antagonists |
-
2002
- 2002-03-27 EP EP02731174A patent/EP1373206B1/en not_active Expired - Lifetime
- 2002-03-27 KR KR10-2003-7012566A patent/KR20030083015A/ko not_active Withdrawn
- 2002-03-27 MX MXPA03008801A patent/MXPA03008801A/es active IP Right Grant
- 2002-03-27 AR ARP020101139A patent/AR033622A1/es unknown
- 2002-03-27 CN CNB028076567A patent/CN1253435C/zh not_active Expired - Fee Related
- 2002-03-27 NZ NZ528011A patent/NZ528011A/en unknown
- 2002-03-27 JP JP2002577784A patent/JP4303969B2/ja not_active Expired - Fee Related
- 2002-03-27 WO PCT/US2002/009490 patent/WO2002079157A1/en not_active Ceased
- 2002-03-27 HU HU0400389A patent/HUP0400389A3/hu unknown
- 2002-03-27 ES ES02731174T patent/ES2318009T3/es not_active Expired - Lifetime
- 2002-03-27 IL IL15771302A patent/IL157713A0/xx unknown
- 2002-03-27 CA CA002442210A patent/CA2442210C/en not_active Expired - Fee Related
- 2002-03-27 AT AT02731174T patent/ATE418542T1/de not_active IP Right Cessation
- 2002-03-27 US US10/107,992 patent/US6689783B2/en not_active Expired - Fee Related
- 2002-03-27 AU AU2002303168A patent/AU2002303168B2/en not_active Expired - Fee Related
- 2002-03-27 DE DE60230491T patent/DE60230491D1/de not_active Expired - Lifetime
- 2002-03-28 MY MYPI20021141A patent/MY134019A/en unknown
-
2003
- 2003-09-12 ZA ZA200307171A patent/ZA200307171B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1253435C (zh) | 2006-04-26 |
| HK1057211A1 (en) | 2004-03-19 |
| CN1500078A (zh) | 2004-05-26 |
| ATE418542T1 (de) | 2009-01-15 |
| HUP0400389A2 (hu) | 2004-08-30 |
| JP2004524360A (ja) | 2004-08-12 |
| DE60230491D1 (de) | 2009-02-05 |
| AR033622A1 (es) | 2003-12-26 |
| US20030087912A1 (en) | 2003-05-08 |
| US6689783B2 (en) | 2004-02-10 |
| CA2442210C (en) | 2009-09-08 |
| MY134019A (en) | 2007-11-30 |
| AU2002303168B2 (en) | 2005-10-06 |
| CA2442210A1 (en) | 2002-10-10 |
| NZ528011A (en) | 2004-08-27 |
| ES2318009T3 (es) | 2009-05-01 |
| IL157713A0 (en) | 2004-03-28 |
| ZA200307171B (en) | 2004-12-13 |
| EP1373206B1 (en) | 2008-12-24 |
| HUP0400389A3 (en) | 2008-03-28 |
| EP1373206A1 (en) | 2004-01-02 |
| MXPA03008801A (es) | 2004-02-18 |
| WO2002079157A1 (en) | 2002-10-10 |
| JP4303969B2 (ja) | 2009-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20030926 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |