KR20030063914A - Manufacture method of remedy matter for disease mouth and throat - Google Patents

Manufacture method of remedy matter for disease mouth and throat Download PDF

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KR20030063914A
KR20030063914A KR1020020004268A KR20020004268A KR20030063914A KR 20030063914 A KR20030063914 A KR 20030063914A KR 1020020004268 A KR1020020004268 A KR 1020020004268A KR 20020004268 A KR20020004268 A KR 20020004268A KR 20030063914 A KR20030063914 A KR 20030063914A
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alum
weight
oral
throat
diseases
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KR1020020004268A
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Korean (ko)
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이재준
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이재준
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

PURPOSE: A method of preparing a composition for treating oral and throat diseases using Persicaria tinctoria H. Gross, Galla Rhois, alum and Croton tiglium L. is provided. Therefore, the composition is effective for treatment of various oral diseases, namely a refractory disease such as oral inflammation, coated tongue, cancer of the oral cavity, cancer of the tongue or the like, acute and chronic tonsillitis and oral and throat pain(laryngopharyngitis). CONSTITUTION: A mixture of 3 to 4.5% by weight of alum and 0.2 to 1.25% by weight of Croton tiglium L. is heated at 70 to 120deg.C for 10 to 15min, blended with 3 to 4.5% by weight of alum and heated at 70 to 120deg.C for 2 to 3hr. Thereafter, the Croton tiglium L. is removed from the coagulated alum, and 3 to 4.5% by weight of Galla Rhois and 0.85 to 1.85% by weight of Galla Rhois are added to the coagulated alum.

Description

구강 및 인후계통 질환의 치료물질 제조방법{Manufacture method of remedy matter for disease mouth and throat}Manufacture method of remedy matter for disease mouth and throat}

본 발명은 구강 및 인후계통 질환의 치료물질 제조방법에 관한 것으로서, 좀더 상세하게 설명하면, 각종 구강질환과 급만성 편도선염 및 각종 인후계통 질환을 예방 및 완화시키는 구강 및 인후계통 질환의 치료물질 제조방법에 관한 것이다.The present invention relates to a method for producing a therapeutic material for oral and throat diseases, and in more detail, a method for producing a therapeutic material for oral and throat diseases preventing and alleviating various oral diseases, acute tonsillitis and various throat system diseases. It is about.

일반적으로, 구강계통 질환 및 인후계통 질환은 편차가 큰 기후 및 생활환경에 따라 그 질환의 발생빈도가 큰 편이다. 이러한 구강 질환에는 우선 선천적인 기형으로, 주로 토순(兎脣:언청이)과 구개열(口蓋裂)을 들 수 있는데, 유전관계가 중시되고 있으며 흡인력부전(吸引力不全)에 의한 영양장애나 언어장애가 생긴다. 외상으로는 화상 이외에 화학약품의 섭취로 인한 부식 따위가 있고, 염증에는 구내염(口內炎)과 구저염(口底炎) 이외에 항아리손님과 화농성 이하선염(耳下腺炎) 등의 침샘 염증이 있다. 또, 구강종양으로는 치육종(齒肉腫) ·피상낭종(皮狀囊腫)·에나멜 상피종(上皮腫) ·치아종(齒牙腫) ·설암 ·구개암 등을 들 수 있다. 또한 비염이나 비용(鼻茸) ·부비강염(副鼻腔炎)이나 아데노이드 등과 같은 코가 막히는 증세를 일으키면 입으로 호흡하게 되기 때문에 이런 질환은 그 예방 및 치료가 매우 중요하다. 또한, 인후질환에는 편도에 염증이 발생하여 편도가 붓거나 통증을 수반하는 급만성편도성염과 목안이 답답하고 목이 쉬거나 열이 발생하여 인후점막이 헐거나 붓거나 하여 통증이 심할 경우 음식물 섭취 및 호흡이 곤란한 인후통등이 있는데 이 역시 호흡기 계통에 치명적인 악영향을 미치기 때문에 많은 연구를 해오고 있으며, 이에 대한 치료약들도 많이 사용되고 있는 실정이다.In general, oral disease and throat disease is a frequent occurrence of the disease according to the climate and living environment with a large deviation. These oral diseases are first born congenital malformations, mainly saturation (과) and cleft palate (口 蓋 裂), the genetic relationship is important and malnutrition or speech disorder due to aspiration dysfunction (吸引力 不 全) occurs. . In addition to burns, injuries include erosion due to ingestion of chemicals. Inflammation includes salivary glands, such as stomatitis and purulent parotitis, in addition to stomatitis and mouth ulcers. . Examples of oral tumors include dental sarcomas, superficial cysts, enamel epithelial tumors, tooth species, snow cancers, palate cancers, and the like. In addition, because of nasal congestion, nasal congestion, or adenoids such as nasal congestion, breathing through the mouth is very important to prevent and treat these diseases. In addition, throat diseases are caused by inflammation of the tonsils, acute tonsillitis with tonsils or pain and sore throat, sore throat or fever, sore throat or swelling of the throat mucosa. There is a sore throat that is difficult to breathe, and this too has a devastating adverse effect on the respiratory system has been studied a lot, and the treatment for this situation is also used a lot.

그러나, 종래의 구강 및 인후계통 질환 치료에 사용되는 약들은 항생제 또는 소염제가 많았으며, 잦은 사용으로 인한 부작용 및 내성등이 발생하여 차후 재발병시 사용하여도 질환이 치료되거나 완화되지 않는 문제점이 있다.However, the conventional medicines used to treat oral and throat diseases have many antibiotics or anti-inflammatory drugs, and the side effects and resistance caused by frequent use occur, so that the disease may not be cured or alleviated even when used again. .

본 발명은 상기와 같은 문제점을 해결하고자 안출한것으로서, 청대·오배자·백반·파두를 가공·혼합하여 각종 구강질환 및 인후계통 질환을 치료·완화시키고자 하는 구강 및 인후계통 질환의 치료물질 제조방법을 제공하는 데 그 목적이 있다.The present invention has been made to solve the above problems, a method for producing a therapeutic material for oral and throat diseases to treat and alleviate various oral diseases and throat diseases by processing and mixing blue and white, alum, alum, and green onions. The purpose is to provide.

상기 목적은, 본 발명에 따라, 백반 3-4.5%중량과 파두 0.2-1.25%중량을 혼합하여 70-120℃에서 10-15분 가열하여 백반을 용해하는 단계와, 상기 용해된 백반에 70-120℃에서 2-3시간 가열하여 수분을 증발시켜 응고시키는 단계와, 상기 응고된 백반에서 파두를 제거하는 단계와, 상기 응고된 백반에 오배자 3-4.5%중량과 청대 0.85-1.85%중량을 혼합하는 단계와, 상기 혼합물을 분말 가공하는 단계를 포함하는 것을 특징으로 하는 구강 및 인후계통 질환의 치료물질 제조방법에 의해 달성된다.The object is, according to the present invention, by mixing 3-4.5% by weight of alum and 0.2-1.25% by weight of soybeans and heating them at 70-120 ° C. for 10-15 minutes to dissolve the alum. Heating at 120 ° C. for 2-3 hours to evaporate the water to coagulate, removing the curd from the coagulated alum, and mixing 3-4.5% by weight and 0.85-1.85% by weight to the coagulated alum. And it is achieved by a method for producing a therapeutic material for oral and throat diseases characterized in that it comprises the step of powder processing the mixture.

여기서, 상기 혼합물의 혼합비율을 백반 3-4.5%중량과 오배자 0.75-1.25%중량과 파두 0.2-1.25%중량으로하고, 상기 청대를 녹반1-1.5%중량과 담반1-1.5%중량으로 대체하여 혼합하는 것이 바람직하다.Herein, the mixing ratio of the mixture is 3-4.5% by weight of alum, 0.75-1.25% by weight, and 0.2-1.25% by weight of Padu, and the blue belt is replaced with 1-1.5% by weight of green and 1-1.5% by weight of albino. It is preferable to mix.

도 1은 본 발명인 구강 및 인후계통 질환의 치료물질 제조방법에 관한 제조 공정도이다.1 is a manufacturing process chart for a method for producing a therapeutic material for oral cavity and throat disease of the present invention.

이하, 첨부된 도면을 참조하여 본 발명인 구강 및 인후계통 질환의 치료물질 제조방법에 관해 상세하게 설명하면 다음과 같다. 첨부한 도면인 도 1은 본 발명인 구강 및 인후계통 질환의 치료물질 제조방법에 관한 제조 공정도이다.Hereinafter, with reference to the accompanying drawings will be described in detail with respect to the method for producing a therapeutic material of the oral cavity and throat system of the present invention. 1 is a manufacturing process chart for a method for producing a therapeutic material of the oral cavity and throat system of the present invention.

본 발명인 구강 및 인후계통 질환의 치료물질 제조방법은 백반 및 파두를 용해하는 단계와, 백반을 응고하는 단계와, 파두를 제거하는 단계와, 오배자 및 청대를 혼합하는 단계와, 상기 혼합물을 분말하는 단계로 이루어진다.The present invention is a method for producing a therapeutic material for oral cavity and throat disease, the step of dissolving alum and leek, coagulating alum, removing the leek, the step of mixing the gall bladder and chungdae, and powdering the mixture Consists of steps.

상기 백반 및 파두를 용해(101)하는 단계에서는 백반 3-4.5%중량과 파두 0.2-1.25%중량을 혼합하여 70-120℃에서 10-15분 가열하여 백반을 용해하게 된다. 상기한 백반은 황산알루미늄과 리튬 이외의 알칼리금속 ·탈륨 ·암모늄 등 1가(價) 금속의 황산염이 만드는 복염(複鹽)으로 명반(明礬)이라고도 한다. MIA1(SO4)2 ·12H2O 또는 MI2SO4·Al2(SO4)3 ·24H2O의 일반식을 갖는다. 칼륨백반은 응결제 ·매염제(媒染劑) ·방수가공 ·가죽의 무두질이나 사진의 경막액(硬膜液) 등에 사용되는데, 이것을 가열하여 탈수시킨 소백반(燒白礬)은 수렴제(收斂劑)로서 의학용으로 사용된다. 또, 암모늄백반은 암모늄염으로 사용되는 외에, 알루미늄 제조의 중간체가 된다.In the step of dissolving alum and leek (101) is mixed with 3-4.5% weight of alum and 0.2-1.25% weight of alum and heated for 10-15 minutes at 70-120 ℃ to dissolve alum. The alum is a double salt made by sulfates of monovalent metals such as alkali metals, thallium, and ammonium other than aluminum sulfate and lithium, and is also called alum. It has a general formula of MIA1 (SO4) 2 12H2O or MI2SO4Al2 (SO4) 324H2O. Potassium alum is used as a coagulant, mordant, waterproofing, tannery of leather, or dural liquid in photographs. Used for In addition to being used as an ammonium salt, ammonium alum is an intermediate for aluminum production.

상기 백반을 응고(102)하는 단계에서는 상기 용해된 백반에 70-120℃로 2-3시간 가열하여 수분을 증발시켜 백반을 응고시키게 된다.In the step of solidifying 102 the alum, the molten alum is heated to 70-120 ° C. for 2-3 hours to evaporate moisture to solidify the alum.

상기 파두를 제거(103)하는 단계에서는 상기 응고된 백반에서 파두를 제거하게 되는데, 상기 파두는 백반을 응고시키기 위한 열처리 과정에서 파두의 지방분이 제거되면서, 파두가 가지고 있는 유독성이 백반과 중화되어 없어지면서, 수렴(收斂), 거담(祛痰), 지혈(止血), 궤양(潰瘍)등의 치료성분이 발생되며, 파두는 급통작용을 하게된다. 원래 파두는 쌍떡잎식물로 쥐손이풀목 대극과의 상록교목으로 높이는 6∼10m이다. 잎은 어긋나며 길이 2∼6cm의 잎자루가 있다. 잎몸은 달걀 모양이거나 긴 달걀 모양이고 윤이 나며 길이 8∼12cm, 나비 약 6cm이다. 가장자리에 얕은 톱니가 있고 끝은 길게 뾰족하다. 잎자루 밑부분에 2개의 선체(腺體)가 있다. 꽃은 암수한그루로서 3∼5월에 피고 총상꽃차례에 달린다. 꽃이삭은 길이 10∼12cm이며 가지 끝에 달리고 수꽃만 달리는 것과 위쪽은 수꽃, 밑부분은 암꽃이 달리는 것이 있다. 수꽃은 녹색이고 꽃받침이 5개로 갈라지며 5개의 꽃잎이 있으나 암꽃에는 꽃잎이 없다. 열매는 삭과(殼果)로서 길쭉한 둥근 모양이거나 달걀을 거꾸로 세워놓은 모양이며 3개의 둔한 모가 지고 3개의 종자가 들어 있다. 8∼9월 열매가 터지기 전에 따서 종자를 채취한다. 한방에서는 종자를 파두라고 하며 준하제(峻下劑)로 사용한다. 종자에는 파두유라고 하는 30∼45%의 기름이 들어 있는데, 피부에 강한 자극을 주므로 발포제나 준하제로 쓴다. 독성이 강하므로 사용할 때 주의해야한다.In the step of removing 103 the shells, the shells are removed from the solidified alum, and the fats of the shells are removed during the heat treatment to solidify the alum, and the toxicity of the shells is not neutralized with the alum. As you build, therapeutic components such as convergence, expectoration, hemostasis, and ulceration are generated, and Padu has a rapid action. Originally, Paddu is a dicotyledonous plant. It is an evergreen arboretum with Mt. The leaves are alternate, and there are petioles of 2-6cm in length. Leaves are egg-shaped or long egg-shaped, glossy, 8-12cm long, about 6cm butterfly. Shallow tooth on edge and long pointed. There are two hulls at the bottom of petiole. Flowers are male and female, bloom in March-May, hang on inflorescences. Isaac is 10-12cm long, hangs at the end of a branch, only male flowers are running, the upper part is male flower, and the bottom is female flower running. The male flower is green, the calyx is divided into 5, and there are 5 petals, but the female flower has no petals. Fruits are capsules, elongated, round, or upside down, with three dull hairs and three seeds. Pick the seeds before the fruit bursts from August to September. In oriental medicine, seeds are called papdu and used as a semi-lowering agent. Seeds contain 30-45% oil, called soybean oil, which is used as a foaming agent or as a laxative because it gives strong irritation to the skin. Because of its high toxicity, use caution when using it.

상기 혼합단계(104)에서는 응고된 백반에 정선된 오배자 3-4.5%중량과 청대 0.85-1.85%중량을 첨가하는데, 상기 오배자는 매미목[同翅目] 진딧물과의 오배자면충이 옻나무과의 붉나무(오배자나무)의 잎에 기생하여 만든 벌레혹으로, 한방에서는 수렴(收斂) ·지혈 ·해독 ·항균의 효력이 있어, 설사 ·탈항 ·위궤양 ·십이지장궤양 ·도한 ·유정(遺精) ·혈변 ·혈뇨 ·구내염 등에 처방한다.In the mixing step 104, 3-4.5% by weight and 0.85-1.85% by weight of selected gall bladder are added to the coagulated alum. It is an insect worm parasitic on a leaf of a tree), and it is effective in acupuncture, hemostasis, detoxification and antibacterial in oriental medicine. Prescribe on back.

상기 혼합물을 분말가공(105)하는 단계에서는 파두를 제거한 백반과 오배자와 청대를 혼합하여 분말화하여 가공한다.In the step of powder processing 105, the mixture is powdered and processed by mixing the alum and the gall bladder and the blue sack from which the green onion is removed.

또한, 상기 혼합물의 혼합비율을 백반 3-4.5%중량과 오배자 0.75-1.25%중량과 파두 0.2-1.25%중량으로하고, 상기 청대를 정제된 녹반1-1.5%중량과 담반1-1.5%중량으로 대체하여 혼합하여 분말가공할 수 있다.Further, the mixing ratio of the mixture was 3-4.5% by weight of alum, 0.75-1.25% by weight, and 0.2-1.25% by weight of green onion. Alternatively, it can be mixed and processed into powder.

이와같은 제조방법으로 제조된 물질은 구강염증, 설태, 설궤양, 구강암, 설암등의 난치성 질환에 효과가 있으며, 급성편도선염과 각종 인후염증 및 인후통에 효과가 있어, 기존의 소염제 또는 항생제와는 달리 내성과 같은 부작용이 없어 사용상 효율적이다.The material produced by such a manufacturing method is effective in refractory diseases such as oral inflammation, tongue, ulcer, oral cancer, and snow cancer, and is effective in acute tonsillitis and various sore throats and sore throats, unlike conventional anti-inflammatory or antibiotics. It is effective in use because there is no side effect such as resistance.

본 발명인 구강 및 인후계통 질환의 치료물질 제조방법은 그 제조방법이 간단하며, 그 제조물은 각 종 구강질환 즉, 구강염증, 설태, 설궤양, 구강암, 설암등의 난치성질환과, 급만성편도염 및 각종 인후통(인후염)에 탁월한 효과가 있어 사용자의 사용상 효율성을 극대화 하는 매우 훌륭한 발명이다.The present invention is a method for producing a therapeutic material for oral cavity and throat disease is a simple method, the preparation is a variety of oral diseases, such as oral inflammation, tongue, tongue ulcers, oral cancer, tongue cancer, intractable diseases such as acute tonsillitis, and It is an excellent effect for maximizing user's efficiency because it has an excellent effect on various sore throats.

Claims (2)

백반 3-4.5%중량과 파두 0.2-1.25%중량을 혼합하여 70-120℃에서 10-15분 가열하여 백반을 용해하는 단계와;Mixing alum with 3-4.5% by weight and 0.2-1.25% by weight of Padu and heating it at 70-120 ° C. for 10-15 minutes to dissolve the alum; 상기 용해된 백반에 70-120℃에서 2-3시간 가열하여 수분을 증발시켜 응고시키는 단계와;Solidifying the molten alum by heating at 70-120 ° C. for 2-3 hours to evaporate moisture; 상기 응고된 백반에서 파두를 제거하는 단계와;Removing the head from the solidified alum; 상기 응고된 백반에 오배자 3-4.5%중량과 청대 0.85-1.85%중량을 혼합하는 단계와;Mixing 5-4.5% by weight and 0.85-1.85% by weight to the coagulated alum; 상기 혼합물을 분말 가공하는 단계를 포함하는 것을 특징으로 하는 구강 및 인후계통 질환의 치료물질 제조방법.Method for producing a therapeutic material for oral and throat disease, characterized in that it comprises the step of powder processing the mixture. 제 1항에 있어서,The method of claim 1, 상기 혼합물의 혼합비율을 백반 3-4.5%중량과 오배자 0.75-1.25%중량과 파두 0.2-1.25%중량으로하고, 상기 청대를 녹반1-1.5%중량과 담반1-1.5%중량으로 대체하여 혼합하는 것을 특징으로 하는 구강 및 인후계통 질환의 치료물질 제조방법.The mixing ratio of the mixture is 3-4.5% by weight of alum, 0.75-1.25% by weight, and 0.2-1.25% by weight of Padu, and mixed by replacing the blue belt with 1-1.5% by weight of green and 1-1.5% by weight of albino. Method for producing a therapeutic material for oral cavity and throat disease, characterized in that.
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