CN105727230B - One kind treats dermopathic rose Chinese medicine composition and its preparation method and application - Google Patents
One kind treats dermopathic rose Chinese medicine composition and its preparation method and application Download PDFInfo
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Abstract
The invention belongs to biomedicine technical field, and in particular to one kind treats dermopathic rose Chinese medicine composition and its preparation method and application.The rose Chinese medicine composition contains rose, orange peel, ginger, gamboge and borneol, has significant therapeutic effect to the skin disease as caused by fungal infection, can be applied in the medicine for preparing treatment dermatophytid infection.
Description
Technical field
The invention belongs to biomedicine technical field, and in particular to one kind treat dermopathic rose Chinese medicine composition and its
Preparation method and application.
Background technology
Most common fungal infection dermatoses are exactly dermatophytosis, are primarily referred to as by the dermatophyte of close keratoprotein
Infection causes, including trichophyton, Microsporon and Epidermophyton, invades the skin, hair, deck of humans and animals, draws
The infection risen is referred to as dermatophytosis.At present dermatophytosis still by site of pathological change name as favus of the scalp, ringworm of the body, jock itch, the tinea manuum,
Tinea pedis, tinea versicolor, onychomycosis etc..Favus of the scalp involves children more, and adult is rare, including favus, tinea alba and black-dot ring, and favus is by being permitted Lan Shi
Achorion infection causes, and tinea alba is caused by the infection of Microsporum ferrugineum microsporum lanosum, and black-dot ring is by Trichophyton violaceum
Trichophyton tonsurans infection causes.Fungi sense caused by ringworm of the body (skin in addition to hand, foot, hair, deck and stock private parts)
Dye, it is mainly seen between twenty and fifty and male, is apt to occur in face, trunk and four limbs near-end.Ringworm of the body and jock itch are mainly by Trichophyton rubrum
Trichophyton gypseum, the infection of microsporum lanosum acrothesium floccosum cause.The tinea manuum for palm dermatophyte infect, with into
Year, people was common.Onset slowly expands in a certain position of palm, finally involves most or all even both sides palm.Tinea pedis is foot
The dermatophyte infection in portion, is more common in adult, morbidity season is obvious, and summer and autumn are seriously ill, and Winter-Spring disease subtracts.The tinea manuum, tinea pedis and ringworm of the body
Mainly caused by Trichophyton rubrum trichophyton gypseum, acrothesium floccosum, trichophyton meginii infection.Tinea versicolor is often sent out in more
The person between twenty and fifty of sweat constitution, it is apt to occur in neck, omoplate, thoracic dorsal, especially hidrosis position and four limbs proximal part.Onychomycosis is that dermatophytes is invaded
Violate disease caused under deck or first.
At present for the skin disease by fungal infection mainly based on the antibiosis extract for treating such as imidazoles, Ciclopirox Olamine, effect
Tend not to satisfactory, easily produce drug resistance and side effect is big, and the treatment of some Chinese medicine class medicines of market sale
Effect is not again notable.Therefore, seeking a kind of medicine of effective treatment fungal skin infections, to be always that this area is to be solved ask
Topic.
For above present Research, the existing one kind that provides of the present invention treats dermopathic rose Chinese medicine composition, the rose
Chinese medicine composition has significant therapeutic effect to the skin disease as caused by fungal infection.Present invention simultaneously provides the rose Chinese medicine
The preparation method and application of composition.
The content of the invention
It is an object of the invention to provide one kind to treat dermopathic rose Chinese medicine composition, to the skin as caused by fungal infection
Skin disease has significant therapeutic effect.
It is a further object to provide the preparation method of above-mentioned Chinese medicine composition.
It is a further object to provide the application of above-mentioned Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions：
One kind treats dermopathic rose Chinese medicine composition, and the rose Chinese medicine composition contains rose, and orange peel is raw
Ginger, gamboge, borneol.
One kind treats dermopathic rose Chinese medicine composition, the rose Chinese medicine composition contain following weight than group
Point：Rose 10-20 parts, orange peel 10-30 parts, ginger 10-30 parts, gamboge 10-20 parts, borneol 1-5 parts.
One kind treats dermopathic rose Chinese medicine composition, the rose Chinese medicine composition contain following weight than group
Point：15 parts of rose, 15 parts of orange peel, 15 parts of ginger, 15 parts of gamboge, 2 parts of borneol.
One kind treats dermopathic rose Chinese medicine composition, the rose Chinese medicine composition contain following weight than group
Point：20 parts of rose, 30 parts of orange peel, 30 parts of ginger, 20 parts of gamboge, 5 parts of borneol.
The preparation method of the dermopathic rose Chinese medicine composition for the treatment of is as follows：
(1) rose is taken, orange peel, ginger, is proportionally mixed, adds distilled water 3L, 80 DEG C decoct half an hour, in triplicate
100ml is concentrated into after mixing, obtains the three herbal medicine aqueous solution；
(2) gamboge is taken, the finely ground mixing of borneol, after crossing the sieve of 100 mesh, adds the obtained three herbal medicine aqueous solution in (1),
The rose Chinese medicine composition is produced after mixing.
The dermopathic rose Chinese medicine composition for the treatment of can be applied in the medicine for preparing treatment dermatophytid infection.Its
In, the fungi is Candida albicans (Candida albicans).
Above-mentioned rose Chinese medicine composition as the pharmaceutical preparation of effective component is creme, emulsion, paste, pulvis, lotion, solidifying
Jelly, aerosol, plastics, tincture and spirit etc..
Rose Chinese medicine composition of the present invention can add the mulsers such as castor oil, triethanolamine, be prepared after stirring and evenly mixing
Into emulsion.
Rose Chinese medicine composition of the present invention can add vaseline, lanolin excipient prepares paste making agent.
Chinese medicine composition of the present invention can be used for treatment skin disease as caused by fungal infection, such as：Favus of the scalp, ringworm of the body,
Jock itch, the tinea manuum, tinea pedis, tinea versicolor, onychomycosis etc..
First cleaned before medication with warm water and treat coating position, open pore, then carry out embrocating using of the present invention
Decoction prepared by method, once in the morning and once at night.General couple of days takes effect, basic almost recovery from illness after one month.Patient is during medication
It should be particularly noted that diet, should avoid tobacco and wine, seafood, capsicum isothermal hot article, and then should sufficient intake with milk, vegetables and fruit
To ensure nutrition.Children must use under the monitoring of adult, pregnant woman's disabling；Medicine is please placed on what children were not readily accessible to
Place.
The dermopathic rose Chinese medicine composition reasonable recipe for the treatment of of the present invention, compatibility science, its medicament composing prescription ginseng
Plurality of medical pharmacopeia is examined, pharmacological basis are：
Rose：Rose sweet and slightly bitter taste, slightly warm in nature, Return liver, spleen, stomach.Rose contains abundant natural complex
C, protein, mineral matter etc., there is the beautifying skin-protection function of highly significant, energy whitening effect, soft skin, smooth microgroove, in advance
Anti-wrinkle, skin regeneration can be promoted, make skin keep elasticity and gloss.Be adapted to various skin quality, to dry skin, color spot, scar,
Wound, burn and scald, sunburn, eczema, aging skin all have splendid effect.
Orange peel：Also known as dried orange peel, work hard, temperature.Enter spleen, lung channel.In reasonable controlled atmosphere, eliminating dampness and eliminating phlegm effect, available for treating
The taste stagnation of the circulation of vital energy, abdominal fullness and distention, vomiting, there is anti-inflammatory, antiulcer, choleretic effect.
Ginger：Ginger has diverging, preventing or arresting vomiting, cough-relieving and other effects in traditional Chinese medicine and pharmacy.Ginger contains multiple components, such as ginger
Alkene, zingiberol, zingiberone etc., it is the important spices of food, cosmetics.
Gamboge：Nature and flavor are sour, puckery, cool in nature.Detumescence, attacks poison, rotten sore of dispelling, hemostasis, desinsection.Cure mainly：For swollen ulcer drug, burst
Ulcer, wet sore, tumour, stubborn dermatitis, treating swelling and pain by traumatic injury, sore hinder bleeding and scald.
Borneol：Acrid flavour, hardship, cool in nature, the thoughts of returning home, lung channel.Effect：Lead to all keys, dissipate stagnated fire, remove screen improving eyesight, swelling and pain relieving.It is main
Control：Apoplexy lockjaw, pyreticosis coma, frightened epilepsy phlegm fan, deafness with qi stagnation, larynx numbness, aphtha, tympanitis, carbuncle swells, hemorrhoid, mesh also screen film, pinworm
Parasitosis.
The beneficial effects of the present invention are：
Rose Chinese medicine composition of the present invention has sterilization, removing toxic substances, itching-relieving action, to the skin as caused by fungal infection
Disease has significant therapeutic effect, available for fungal infections such as treatment favus of the scalp, ringworm of the body, jock itch, the tinea manuum, tinea pedis, tinea versicolor, onychomycosis
Skin disease.
The Chinese medicine composition has no side effect, and preparation method is simple, and production cost is low.
Illustrate technical scheme of the present invention below by way of specific embodiment, embodiment is illustrative rather than limited
Property, can include several embodiments according to limited scope, thus the change in the case where not departing from present general inventive concept and
Modification, should belong within protection scope of the present invention.
Embodiment
The preparation method of the rose Chinese medicine composition of embodiment 1
(1) rose 20g is taken, orange peel 30g, ginger 30g, is proportionally mixed, adds distilled water 3L, 80 DEG C to decoct half small
When, 100ml is concentrated into after mixing in triplicate, obtains the three herbal medicine aqueous solution；
(2) gamboge 20g is taken, the finely ground mixings of borneol 5g, after crossing the sieve of 100 mesh, adds obtained three herbal medicine water in (1)
Solution, the rose Chinese medicine composition is produced after mixing.
The preparation method of the paste of the rose Chinese medicine composition of embodiment 2
(1) rose 15g is taken, orange peel 15g, ginger 15g, is proportionally mixed, adds distilled water 3L, 80 DEG C to decoct half small
When, 100ml is concentrated into after mixing in triplicate, obtains the three herbal medicine aqueous solution；
(2) gamboge 15g is taken, the finely ground mixings of borneol 2g, after crossing the sieve of 100 mesh, adds obtained three herbal medicine water in (1)
Solution, the rose Chinese medicine composition is produced after mixing.
(3) rose Chinese medicine composition in (2) is concentrated into medicinal extract shape, takes 10g vaseline, 2g lanolin, 60 DEG C after mixing
Heating and melting, when temperature is down to and maintains 40 DEG C, rose Chinese medicine composition medicinal extract is added, is stirred continuously, institute is produced after mixing
State the paste of rose Chinese medicine composition.
The preparation method of the emulsion of the rose Chinese medicine composition of embodiment 3
(1) rose 10g, orange peel 10g, ginger 10g are taken, is proportionally mixed, adds distilled water 3L, 80 DEG C to decoct half small
When, 100ml is concentrated into after mixing in triplicate, obtains the three herbal medicine aqueous solution；
(2) gamboge 10g, the finely ground mixings of borneol 1g are taken, after crossing the sieve of 100 mesh, adds obtained three herbal medicine water in (1)
Solution, the rose Chinese medicine composition is produced after mixing.
(3) 5g castor oil is taken, 5g triethanolamines is added, stirs while adding, emulsus oil mixture is produced after mixing, afterwards
Rose Chinese medicine composition in (2) is slowly added to, it is quick to stir, produce the emulsion of the rose Chinese medicine composition.
The effect of 4 rose Chinese medicine composition of embodiment, is verified
1st, biomaterial
Fungal bacterial strain：Selection causes the most common unicellular fungi of clinical infection -- and Candida albicans is tested；
(the C.albicans ATCC of Candida albicans (Candida albicans) Canidia Albicans ATCC 10231
10231) Guangdong Province's Culture Collection, numbering GIM2.194 are purchased from.
2nd, experimental procedure
(1) experimental group is set
Blank control group：Physiological saline.
Rose Chinese medicine composition high concentration group：(1) rose 20g is taken, orange peel 30g, ginger 30g, proportionally mixes, adds
Distilled water 3L, 80 DEG C decoct half an hour, are concentrated into 100ml after mixing in triplicate, obtain the three herbal medicine aqueous solution；(2) gamboge is taken
The finely ground mixing of 20g, borneol 5g, after crossing the sieve of 100 mesh, the obtained three herbal medicine aqueous solution in (1) are added, rose is produced after mixing
Rare Chinese medicine composition high concentration group.
Concentration group in rose Chinese medicine composition：(1) rose 15g is taken, orange peel 15g, ginger 15g, proportionally mixes, adds
Distilled water 3L, 80 DEG C decoct half an hour, are concentrated into 100ml after mixing in triplicate, obtain the three herbal medicine aqueous solution；(2) gamboge is taken
15g, borneol 2g, finely ground mixing, after crossing the sieve of 100 mesh, the obtained three herbal medicine aqueous solution in (1) are added, are produced after mixing
Concentration group in rose Chinese medicine composition.
Rose Chinese medicine composition low concentration group：(1) rose 10g is taken, orange peel 10g, ginger 10g, proportionally mixes, adds
Distilled water 3L, 80 DEG C decoct half an hour, are concentrated into 100ml after mixing in triplicate, obtain the three herbal medicine aqueous solution；(2) gamboge is taken
10g, borneol 1g, finely ground mixing, after crossing the sieve of 100 mesh, the obtained three herbal medicine aqueous solution in (1) are added, are produced after mixing
Rose Chinese medicine composition low concentration group.
Rose wate decocting liquid control group：Rose 20g is taken, adds distilled water 500ml, 80 DEG C decoct half an hour, in triplicate
100ml is concentrated into after mixing, produces rose decocting liquid control group.
Orange peel decocting liquid control group：Orange peel 30g is taken, adds distilled water 500ml, 80 DEG C decoct half an hour, mix in triplicate
After be concentrated into 100ml, produce orange peel decocting liquid control group.
Ginger decocting liquid control group：Ginger 30g is taken, adds distilled water 500ml, 80 DEG C decoct half an hour, mix in triplicate
After be concentrated into 100ml, produce ginger decocting liquid control group.
Gamboge aqueous solution control group：Gamboge 20g is taken, adds distilled water 100ml, gamboge aqueous solution control group is produced after mixing.
Borneol aqueous solution control group：Borneol 5g is taken, adds distilled water 100ml, borneol aqueous solution control group is produced after mixing.
(2) experimental procedure
Experiment is aseptically carried out, and each group medicine is mixed with PDA culture medium respectively, drug containing PDA is prepared respectively and consolidates
Body plating medium.After Candida albicans culture 18h, draw 200 microlitres of bacterium solutions and be applied to drug containing PDA solid plate culture mediums
On, with coating rod coating it is uniform after, be put into 25 DEG C of incubators cultivate 48h after observe fungi growing state, calculate each experimental group
The total plate count grown on PDA solid plate culture mediums, and growth inhibition ratio is calculated, inhibiting rate=(blank control group bacterium colony is total
Number-experimental group total plate count)/blank control group total plate count × 100%.
(3) experimental result
The In Vitro Bacteriostasis of rose Chinese medicine composition is shown in Table 1.
As a result show, each concentration group of rose Chinese medicine composition significantly inhibits effect to albicans growth, suppresses
Effect reaches 98.8%-100%；Fungistatic effect is substantially better than rose wate decocting liquid control group (32.4%), orange peel decocting liquid pair
Compareed according to group (16.8%), ginger decocting liquid control group (82.3%), gamboge aqueous solution control group (6.1%) and the borneol aqueous solution
Group (81.2%).Wherein, the fungistatic effect of high concentration group and middle concentration group is best, is 100%.
The In Vitro Bacteriostasis effect of the rose Chinese medicine composition of table 1
Note：Flat board grows without fungi：-.Colony growth situation represents with "+", and colony growth is good and clump count>30/ ware：
+++；Colony growth is slow and the ware of clump count 10~30/：++；Fungi grows smaller and clump count<10 wares：+.
Proved by above example, the dermopathic rose Chinese medicine composition for the treatment of provided by the invention has sterilization, solution
Poison, itching-relieving action, there is significant therapeutic effect to the skin disease as caused by fungal infection, can treat favus of the scalp, ringworm of the body, jock itch,
The fungal infection skin disease such as the tinea manuum, tinea pedis, tinea versicolor, onychomycosis.It can be applied in the medicine for preparing treatment dermatophytid infection.
Claims (7)
1. one kind treatment dermopathic rose Chinese medicine composition as caused by fungal infection, it is characterised in that the rose Chinese medicine
Composition is made up of rose, orange peel, ginger, gamboge, borneol, wherein the weight ratio of each medicine is：Rose 10-20 parts, tangerine
Skin 10-30 parts, ginger 10-30 parts, gamboge 10-20 parts, borneol 1-5 parts.
2. a kind for the treatment of dermopathic rose Chinese medicine composition, its feature as caused by fungal infection as claimed in claim 1
Be, the rose Chinese medicine composition by following weight than component be made：15 parts of rose, 15 parts of orange peel, 15 parts of ginger, rattan
It is yellow 15 parts, 2 parts of borneol.
A kind of 3. rose Chinese medicine composition dermopathic as caused by fungal infection as claimed in claim 1, it is characterised in that
The rose Chinese medicine composition by following weight than component be made：20 parts of rose, 30 parts of orange peel, 30 parts of ginger, gamboge 20
Part, 5 parts of borneol.
A kind of 4. treatment as described in claim any one of 1-3 dermopathic rose Chinese medicine composition as caused by fungal infection
Preparation method, it is characterised in that the preparation method is as follows：
(1) rose is taken, orange peel, ginger, is proportionally mixed, adds distilled water 3L, 80 DEG C decoct half an hour, mix in triplicate
After be concentrated into 100ml, obtain the three herbal medicine aqueous solution；
(2) gamboge is taken, the finely ground mixing of borneol, after crossing the sieve of 100 mesh, the obtained three herbal medicine aqueous solution in (1) is added, mixes
The rose Chinese medicine composition is produced after even.
5. the dermopathic rose Chinese medicine composition as caused by fungal infection of the treatment as described in claim any one of 1-3 is being made
Application in the medicine of standby treatment dermatophytid infection.
6. application as claimed in claim 5, it is characterised in that the fungi is Candida albicans.
7. application as claimed in claim 5, it is characterised in that medicine system of the rose Chinese medicine composition as effective component
Agent is creme, emulsion, paste, pulvis, lotion, gel, aerosol, plastics, tincture and spirit.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297759A (en) * | 1999-11-09 | 2001-06-06 | 魏明志 | Beriberi treating medicine liquid |
| CN105233144A (en) * | 2015-09-10 | 2016-01-13 | 山东宝来利来生物工程股份有限公司 | Traditional Chinese medicine preparation for treating dermatomycoses of animals and preparation method of traditional Chinese medicine preparation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057213C (en) * | 1996-01-22 | 2000-10-11 | 李秀香 | Chinese medicinal preparation for treatment skin disease and its prepn. method |
| CN101181474B (en) * | 2007-11-09 | 2010-08-25 | 佳程药业（贵州）有限责任公司 | Chinese medicine ointment for curing skin diseases as well as producing and detecting method thereof |
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- 2016-03-24 CN CN201610166399.XA patent/CN105727230B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297759A (en) * | 1999-11-09 | 2001-06-06 | 魏明志 | Beriberi treating medicine liquid |
| CN105233144A (en) * | 2015-09-10 | 2016-01-13 | 山东宝来利来生物工程股份有限公司 | Traditional Chinese medicine preparation for treating dermatomycoses of animals and preparation method of traditional Chinese medicine preparation |
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