KR20030033819A - 2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체 - Google Patents
2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체 Download PDFInfo
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- KR20030033819A KR20030033819A KR1020010065967A KR20010065967A KR20030033819A KR 20030033819 A KR20030033819 A KR 20030033819A KR 1020010065967 A KR1020010065967 A KR 1020010065967A KR 20010065967 A KR20010065967 A KR 20010065967A KR 20030033819 A KR20030033819 A KR 20030033819A
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- formula
- methyl
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- represented
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (5)
- 하기 화학식 1로 표시되는 항바이러스 효과를 갖는 1-(3-플루오로-히드록시-5-멀캅토메틸-테트라히드로-푸란-2-일)-5-메틸-1H-피리미딘-2,4-디온.[화학식 1]
- 하기 화학식 2로 표시되는 항바이러스 효과를 갖는 1-(3-플루오로-히드록시-5-(메틸-옥소메틸렌-14-설파닐메틸)-테트라히드로-푸란-2-일)-5-메틸-1H-피리미딘-2,4-디온.[화학식 2]
- 하기 화학식 3의 L-FMAU 화합물을 THF, 벤젠, 디에틸에테르, 디옥산, HMPT, 피리딘,N,N-디메틸포름아미드 중에서 선택되는 용매 하에 트리알킬포스핀, 디알킬아조디카르복실레이트, 티올아세트산을 반응물질로 하여 -10℃∼상온의 온도에서반응시키는 것을 특징으로 하는 상기 화학식 2의 화합물을 제조하는 방법.[화학식 3]
- 제 3 항에 있어서, 트리알킬포스핀의 알킬기는 페닐 또는 페녹시 이고, 디알킬아조디카르복실레이트의 알킬기는 에틸 또는 이소프로필 인 것을 특징으로 하는 상기 화학식 2의 화합물을 제조하는 방법.
- 상기 화학식 2의 화합물을 소듐 에톡사이드, 소듐 메톡사이드, 디에틸아민, 디이소프로필아민, 암모니아 중에서 선택되는 1종을 탈아세탈 시약으로 사용하고, 메탄올, 에탄올, 이소프로판놀 중에서 선택되는 용매 하에 0∼60℃에서 반응시켜 상기 화학식 1의 화합물을 제조하는 방법.
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KR10-2001-0065967A KR100487992B1 (ko) | 2001-10-25 | 2001-10-25 | 2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체 |
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KR10-2001-0065967A KR100487992B1 (ko) | 2001-10-25 | 2001-10-25 | 2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체 |
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KR20030033819A true KR20030033819A (ko) | 2003-05-01 |
KR100487992B1 KR100487992B1 (ko) | 2005-05-09 |
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KR10-2001-0065967A KR100487992B1 (ko) | 2001-10-25 | 2001-10-25 | 2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체 |
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Families Citing this family (1)
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KR100976778B1 (ko) * | 2003-04-17 | 2010-08-18 | 부광약품 주식회사 | 1-(2'-플루오로-베타-엘-아라비노푸라노실)티민의 황 유도체를 유효 활성 성분으로 하는 b형 간염 바이러스 치료제 |
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US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
TW434252B (en) * | 1997-07-23 | 2001-05-16 | Univ Georgia Res Found | Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine |
KR100449618B1 (ko) * | 1998-03-27 | 2004-11-16 | 부광약품 주식회사 | 2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법 |
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