KR20030016239A - 녹내장 치료용의 5-ｈｔ２ 및 5-ｈｔ１ａ 아고니스트활성을 지닌 화합물 - Google Patents

녹내장 치료용의 5-ｈｔ２ 및 5-ｈｔ１ａ 아고니스트활성을 지닌 화합물 Download PDF

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Publication number
KR20030016239A
KR20030016239A KR1020027012169A KR20027012169A KR20030016239A KR 20030016239 A KR20030016239 A KR 20030016239A KR 1020027012169 A KR1020027012169 A KR 1020027012169A KR 20027012169 A KR20027012169 A KR 20027012169A KR 20030016239 A KR20030016239 A KR 20030016239A
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KR
South Korea
Prior art keywords
aminopropyl
compound
compounds
methyl
iop
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020027012169A
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English (en)
Korean (ko)
Inventor
로버트 제이. 주니어 콜리어
토마스 알. 딘
마크 알. 헬베르그
Original Assignee
알콘, 인코퍼레이티드
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Application filed by 알콘, 인코퍼레이티드 filed Critical 알콘, 인코퍼레이티드
Publication of KR20030016239A publication Critical patent/KR20030016239A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Liquid Crystal Substances (AREA)
KR1020027012169A 2000-03-17 2001-02-20 녹내장 치료용의 5-ｈｔ２ 및 5-ｈｔ１ａ 아고니스트활성을 지닌 화합물 Withdrawn KR20030016239A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19027900P 2000-03-17 2000-03-17
US60/190,279 2000-03-17

Publications (1)

Publication Number Publication Date
KR20030016239A true KR20030016239A (ko) 2003-02-26

Family

ID=22700682

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020027012169A Withdrawn KR20030016239A (ko) 2000-03-17 2001-02-20 녹내장 치료용의 5-ｈｔ２ 및 5-ｈｔ１ａ 아고니스트활성을 지닌 화합물
KR1020027012170A Expired - Fee Related KR100749191B1 (ko) 2000-03-17 2001-02-23 외망막의 질환을 치료하기에 유용한 ５－ｈｔ１ａ 활성을 가진 화합물
KR1020027012171A Withdrawn KR20030009390A (ko) 2000-03-17 2001-02-23 시야 감소를 억제하는데 유용한 5-ｈｔ 활성을 갖는화합물

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020027012170A Expired - Fee Related KR100749191B1 (ko) 2000-03-17 2001-02-23 외망막의 질환을 치료하기에 유용한 ５－ｈｔ１ａ 활성을 가진 화합물
KR1020027012171A Withdrawn KR20030009390A (ko) 2000-03-17 2001-02-23 시야 감소를 억제하는데 유용한 5-ｈｔ 활성을 갖는화합물

Country Status (18)

Country Link
EP (3) EP1263434A1 (https=)
JP (5) JP2003527423A (https=)
KR (3) KR20030016239A (https=)
CN (2) CN1418100A (https=)
AR (1) AR028258A1 (https=)
AT (1) ATE247507T1 (https=)
AU (5) AU2001238552A1 (https=)
BR (3) BR0109193A (https=)
CA (3) CA2400637A1 (https=)
DE (1) DE60100625T2 (https=)
DK (1) DK1263504T3 (https=)
ES (1) ES2204848T3 (https=)
MX (3) MXPA02009071A (https=)
PL (1) PL203709B1 (https=)
PT (1) PT1263504E (https=)
TW (1) TWI268777B (https=)
WO (3) WO2001070223A1 (https=)
ZA (1) ZA200206350B (https=)

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US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
US20030207890A1 (en) 2001-02-23 2003-11-06 Collier Robert J Compounds with 5-ht1a activity useful for treating disorders of the outer retina
BR0109193A (pt) * 2000-03-17 2003-05-27 Alcon Inc Compostos com atividade agonista 5-ht2 e 5-ht1a para tratamento do glaucoma
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
BR0316775A (pt) 2002-12-13 2005-11-01 Alcon Inc Novos análogos de benzopirano e seu uso para o tratamento de glaucoma
JP2004262812A (ja) * 2003-02-28 2004-09-24 Rohto Pharmaceut Co Ltd 眼圧低下剤
JP4808612B2 (ja) * 2003-04-25 2011-11-02 田辺三菱製薬株式会社 アルキレンジオキシベンゼン誘導体を含む経口投与用組成物
US7476687B2 (en) 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
TW200520760A (en) 2003-12-15 2005-07-01 Alcon Inc Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US20050244463A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
EP2248524A3 (en) 2004-08-25 2011-03-09 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
WO2008117269A2 (en) 2007-03-28 2008-10-02 Atir Holding S.A. Heterotri cyciii c compounds as serotonergic and/or dopaminergic agents and uses thereof
EP2742936A1 (en) 2006-05-16 2014-06-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
WO2008024846A2 (en) * 2006-08-25 2008-02-28 Allergan, Inc. Brimonidine and timolol compositions
EP2789338A3 (en) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Condensed pyridine derivate and use thereof
TW201010727A (en) * 2008-09-03 2010-03-16 Alcon Res Ltd Pharmaceutical composition having relatively low ionic strength
PH12012500928A1 (en) 2009-11-09 2012-11-26 Allergan Inc Compositions and methods for stimulating hair growth
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
CN109602691A (zh) 2013-02-15 2019-04-12 阿勒根公司 持续药物递送植入物
WO2018064465A1 (en) 2016-09-29 2018-04-05 The Regents Of The University Of California Compounds for increasing neural plasticity
EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC AGENT FOR URINARY INCONTINENCE OF STRESS AND FECAL INCONTINENCE
CN113784962B (zh) 2019-02-27 2025-04-25 加利福尼亚大学董事会 用于治疗脑部疾病的氮杂环庚三烯并-吲哚类和其他杂环
AU2020228289B2 (en) 2019-02-27 2026-02-05 The Regents Of The University Of California N-substituted indoles and other heterocycles for treating brain disorders
TW202333668A (zh) 2021-12-15 2023-09-01 美商德利克斯醫療公司 經苯氧基及苄氧基取代之精神成形素(psychoplastogen)及其用途
PL4452267T3 (pl) * 2021-12-23 2025-06-23 Cilcare Dev Pochodne 4-fenylo-tetrahydropirydyny do leczenia chorób słuchu

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JPH02262518A (ja) * 1989-04-03 1990-10-25 Kaken Pharmaceut Co Ltd 眼圧調整剤
JP2824863B2 (ja) * 1989-07-12 1998-11-18 エーザイ株式会社 α▲下１▼―ブロッカー点眼剤
TW270114B (https=) * 1993-10-22 1996-02-11 Hoffmann La Roche
US5521183A (en) * 1994-08-30 1996-05-28 Allergan Use of 5-HT ligands as anti-pruritic agents
US5998467A (en) * 1995-10-25 1999-12-07 Mitsubishi Chemical Corporation Medicine for oculopathy
JP3958391B2 (ja) * 1995-10-25 2007-08-15 三菱化学株式会社 眼疾患用薬剤
WO1998018458A1 (en) * 1996-10-31 1998-05-07 Alcon Laboratories, Inc. Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
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BR0109193A (pt) * 2000-03-17 2003-05-27 Alcon Inc Compostos com atividade agonista 5-ht2 e 5-ht1a para tratamento do glaucoma

Also Published As

Publication number Publication date
TWI268777B (en) 2006-12-21
JP4789231B2 (ja) 2011-10-12
JP2011153158A (ja) 2011-08-11
WO2001070230A2 (en) 2001-09-27
AU2001238552A1 (en) 2001-10-03
BR0109211A (pt) 2003-02-11
EP1263434A1 (en) 2002-12-11
AR028258A1 (es) 2003-04-30
DE60100625T2 (de) 2004-02-26
CA2400639A1 (en) 2001-09-27
AU2001245310B2 (en) 2005-03-17
AU2005202600A1 (en) 2005-07-07
AU4531001A (en) 2001-10-03
AU2001239836A1 (en) 2001-10-03
MXPA02009073A (es) 2003-03-12
CN1418100A (zh) 2003-05-14
ZA200206350B (en) 2003-08-08
JP2003527423A (ja) 2003-09-16
WO2001070223A1 (en) 2001-09-27
WO2001070230A3 (en) 2002-04-25
DK1263504T3 (da) 2003-12-08
AU2005202600B2 (en) 2008-07-31
CA2399985A1 (en) 2001-09-27
WO2001070222A3 (en) 2002-07-25
JP2003527422A (ja) 2003-09-16
ATE247507T1 (de) 2003-09-15
CA2400639C (en) 2011-08-16
KR20020082885A (ko) 2002-10-31
MXPA02009072A (es) 2003-03-12
PL203709B1 (pl) 2009-11-30
KR20030009390A (ko) 2003-01-29
ES2204848T3 (es) 2004-05-01
JP2003527427A (ja) 2003-09-16
CN1418121A (zh) 2003-05-14
EP1267878A2 (en) 2003-01-02
BR0109230A (pt) 2003-06-03
PT1263504E (pt) 2003-12-31
MXPA02009071A (es) 2003-05-23
CA2400637A1 (en) 2001-09-27
BR0109193A (pt) 2003-05-27
EP1263504B1 (en) 2003-08-20
DE60100625D1 (de) 2003-09-25
CN1198605C (zh) 2005-04-27
JP2011037901A (ja) 2011-02-24
HK1051504A1 (en) 2003-08-08
EP1263504A2 (en) 2002-12-11
PL358306A1 (en) 2004-08-09
WO2001070222A2 (en) 2001-09-27
KR100749191B1 (ko) 2007-08-13

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20020916

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid