KR20020066242A - A herb medicine for treating an arthritis - Google Patents

A herb medicine for treating an arthritis Download PDF

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KR20020066242A
KR20020066242A KR1020010006440A KR20010006440A KR20020066242A KR 20020066242 A KR20020066242 A KR 20020066242A KR 1020010006440 A KR1020010006440 A KR 1020010006440A KR 20010006440 A KR20010006440 A KR 20010006440A KR 20020066242 A KR20020066242 A KR 20020066242A
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arthritis
pain
side effects
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present
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이수찬
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

PURPOSE: Provided is a herbal medicinal composition for arthritis, especially for degenerative arthritis and rheumatic arthritis. The composition has no side effects as well as preventing ongoing arthritis. CONSTITUTION: The composition comprises: (i) as a main ingredient, 55-90wt.% of one or more from the group consisting of Atractylodis, Aralia Continentalis, Acanthopanax, Eucommia ulmoides, Angelica gigas, Lycium, angelica koreana, achyranthes and coix, based on the whole formula weight; and (ii) as a secondary ingredient, 10-45wt.% of one or more from the group consisting of Scutellaria, Crataegus pinnatifida, saussurea Lappa, amomum seed, ginger and sugar ginseng. The main ingredients are powder, while the secondary ingredients are in tablet form.

Description

관절염 치료용 생약제제 {A HERB MEDICINE FOR TREATING AN ARTHRITIS}Herbal medicine for arthritis {A HERB MEDICINE FOR TREATING AN ARTHRITIS}

본 발명은 부작용이 없으면서, 약효가 지속적인 관절염 치료용 생약제제, 특히 퇴행성 관절염 및 류마티스 관절염을 포함하는 관절염 치료용 생약제제에 관한 것이다.The present invention relates to a herbal medicine for the treatment of arthritis without any side effects, particularly a herbal medicine for treating arthritis, including degenerative arthritis and rheumatoid arthritis.

관절염은 한대나 열대지방에서는 별로 발생하지 않고, 습기가 높고 기후 변화가 많으며 채광이 좋지 못한 지방에서 많이 나타나는데, 우리나라도 발병하기 쉬운 조건을 구비하고 있다고 볼 수 있다. 현재, 100 만명 정도의 관절염 환자가 있다고 추정되며, 특히 여성이 남성보다 배이상 많고 그 중에서도 갱년기 여성에게서 많이 볼 수 있는 질환이다.Arthritis rarely occurs in the tropics or the tropics, and it is found in high humidity, high climate change, and poor mining. Korea can be considered to have an easy condition. At present, it is estimated that there are about 1 million arthritis patients, and in particular, women are more than twice as many men, especially among menopausal women.

그중에서도, 퇴행성 관절염 (골관절염 또는 골관절증이라고도 함) 은 관절 연골이 닳아 없어지면서 국소적인 퇴행성 변화가 나타나는 질환으로서 그 원인은 불확실하나, 노쇠 현상이나 과대한 체중과 관계가 깊은 질환이며, 나이가 많아질수록 여성에게서 더 많이 그리고 더 심하게 나타난다. 초기 증상은 한개 또는 두개의 관절이 강직과 함께 쑤시는 듯한 동통이 나타나며, 장기화되면 관절의 변형등을 초래하게 되지만, 퇴행성 관절염은 관절 연골의 퇴행성 변화에 의해 발생되는것이므로 이를 완전히 정지시킬 수 있는 방법은 아직 없고, 치료 목적도 동통을 경감시켜 주며, 관절의 기능을 유지시키고, 변형을 방지하는 데 있다.Among them, degenerative arthritis (also known as osteoarthritis or osteoarthritis) is a disease in which local degenerative changes occur as the articular cartilage wears down. More and worse in women. The initial symptom is pain in one or two joints with stiffness and stiffness, and if prolonged, it causes joint deformity. However, degenerative arthritis is caused by degenerative changes in articular cartilage. Is not yet available, and treatment aims to relieve pain, maintain joint function, and prevent deformation.

류마티스 관절염은 30~50세의 여성에게 1:4의 비율로 많이 나타나는 것으로서, 증상은 손가락, 팔꿈치, 무릎 등의 관절이 좌우대칭적으로 염증을 일으켜 부어서 아프고 굳어지며, 특히 새벽에 심하며 몸이 쇠약해지고 미열도 난다. 급성관절류마티스의 관절증세는 몇 일에서 몇 주 이내에 없어지는데 반하여, 류마티스 관절염은 몇 달 몇 년 동안이나 계속된다. 마침내는 관절의 변형과 탈구, 근(筋) ·건(腱)의 구축(拘縮) 및 강직(强直)을 일으켜 심한 불구가 되기도 한다.Rheumatoid arthritis is a common ratio of 1: 4 in women aged 30 to 50. Symptoms include symmetrical inflammation of the joints of the fingers, elbows, knees, and so on, resulting in swelling and swelling. It becomes weak and feverish. Arthritis in acute joint rheumatism goes away within a few days to weeks, whereas rheumatoid arthritis lasts for months and years. Finally, deformity and dislocation of the joints, muscle and tendon build up and stiffness can cause severe disabilities.

따라서, 관절염 치료에 대한 관심은 매우 크다. 관절염 치료제로서 현재 알려진 약제로는 아스피린, 이부프로펜, 페노 프로펜과 같은 비스테로이드성 소염제; 및 D-페니실라민, 메토트렉세이트와 같은 변형 약제; 및 코르티코스테로이드와 같은 스테로이드성 소염제가 있다.Thus, there is a great interest in treating arthritis. Currently known agents for treating arthritis include nonsteroidal anti-inflammatory agents such as aspirin, ibuprofen, and phenopropene; And modified agents such as D-penicillamine, methotrexate; And steroidal anti-inflammatory agents such as corticosteroids.

일반적으로, 관절염의 치료를 위해서는 약제를 장기간 복용할 필요가 있기 때문에, 부작용이 적은 약제를 적절히 선택하여 사용하여야 함에도 불구하고, 현재 알려진 관절염 치료제는 정도의 차이는 있으나, 개인마다 약물의 효과가 다르고, 부작용이 발생할 수 있다는 문제가 있다.In general, in order to treat arthritis, it is necessary to take drugs for a long time, and even though a drug having a low side effect should be selected and used appropriately, currently known arthritis treatment drugs have a degree of difference, but the effects of drugs vary from person to person. There is a problem that side effects may occur.

이에 본 출원인은, 약물 복용에 따른 부작용을 감소시키면서, 관절염 치료에 효과적인 약제를 개발하기 위해 예의 연구를 수행한 결과, 부작용이 없는 여러가지 성분을 혼합한 관절염 치료용 생약제제를 이용해 본 발명을 완성하였다.즉, 본 발명의 생약제제는 (i) 주성분인 백출, 독활, 오가피, 두충, 당귀, 구기자, 강활, 우슬, 율무로 구성된 군에서 선택된 하나 이상의 성분 및 (ii) 부성분인 황금, 산사, 목향, 사인, 생강, 당삼으로 구성된 군에서 선택된 하나 이상의 성분을 함유하는 것으로서, 효과가 복합적이며, 부작용이 없고, 부성분이 공존하기 때문에 주성분의 흡수가 완화되어 작용이 지속적으로 나타나므로, 관절염, 특히 퇴행성 관절염 및 류마티스 관절염을 포함하는 관절염을 효과적으로 치료할 수 있다.Accordingly, the present applicant has conducted a thorough study to develop an effective drug for the treatment of arthritis while reducing the side effects of taking the drug, and completed the present invention using a herbal medicine for treating arthritis mixed with various components having no side effects. In other words, the herbal preparation of the present invention (i) at least one component selected from the group consisting of white worms, poisonous, scabies, tofu, Angelica, goji berry, rosacea, wedge, yulmu and (ii) golden, hawthorn, moth It contains one or more ingredients selected from the group consisting of, sine, ginger, and ginseng, the effect is complex, there are no side effects, because the co-existence of the sub-components, the absorption of the main component is alleviated, so that the action appears continuously, arthritis, especially degenerative Arthritis, including arthritis and rheumatoid arthritis, can be effectively treated.

따라서, 본 발명의 목적은 부작용이 없는 관절염 치료용 생약제제를 제공하는 것이다.Accordingly, it is an object of the present invention to provide a herbal preparation for treating arthritis without side effects.

또한, 본 발명의 목적은 부작용이 없으면서, 동시에 관절염의 진행을 억제하여, 더이상의 관절염의 진행을 방지할 수 있는 관절염 치료용 생약제제, 특히 퇴행성 관절염 및 류마티스 관절염을 포함하는 관절염 치료용 생약제제를 제공하는 것이다.In addition, an object of the present invention is to suppress the progression of arthritis at the same time without side effects, and to prevent the progression of further arthritis herbal preparations for the treatment of arthritis, in particular arthritis for the treatment of arthritis, including degenerative arthritis and rheumatoid arthritis To provide.

본 발명의 관절염 치료용 생약제제는 생약제제의 전체 중량을 기준으로, (i) 백출, 독활, 오가피, 두충, 당귀, 구기자, 강활, 우슬, 율무로 구성된 군에서 선택된 1 종 이상의 주성분 55 내지 90 %, 및 (ii) 황금, 산사, 목향, 사인, 생강, 당삼으로 구성된 군에서 선택된 1 종 이상의 부성분 10 내지 45 % 를 함유한다.Herbal medicine for treating arthritis of the present invention based on the total weight of the herbal medicine, (i) one or more active ingredients 55 to 90 selected from the group consisting of baekryeok, venom, staphylococcus, nematode, Angelica, wolfberry, vigor, dew, yulmu %, And (ii) 10 to 45% of one or more subcomponents selected from the group consisting of gold, hawthorn, cedar, cod, ginger, and ginseng.

본 발명의 관절염 치료용 생약제제의 구성 성분은 하기와 같은 특성을 각기 갖는다:The components of the herbal preparation for treating arthritis of the present invention each have the following characteristics:

두충 : 보익간신, 강육건골, 혈압강하 작용을 하는 것으로서, 보양강장약으로 내과나 부인과에서 나타나는 퇴행성질병에 주로 쓰이며 골격근 근력증강, 만성 관절염, 고혈압, 고혈당, 동맥경화에 처방된다;Crustacea: Boikansin, strong muscle tendon, blood pressure lowering action, a tonic tonic medicine mainly used for degenerative diseases in internal medicine or gynecology and is prescribed for skeletal muscle strength, chronic arthritis, hypertension, hyperglycemia, arteriosclerosis;

독활 : 진통작용, 진정작용, 혈관수축작용을 하는 것으로서, 만성 류마티스 관절염 및 근육 류마티스 관절염에 효과 있으며 혈압 하강작용을 한다;Toxic: analgesic, sedative, vasoconstrictive, effective in chronic rheumatoid arthritis and rheumatoid arthritis and lowers blood pressure;

백출 : 건위작용, 이뇨작용, 지한작용, 진정작용, 자양작용을 하는 것으로서, 주로 강장제로 많이 사용되며 소화흡수력을 높이고 간장기능과 신체의 저항력을 증강시키며 만성위염 및 위궤양에 효과가 있고, 만성 관절염으로 관절부위에 물이 고였을 때 처방된다;Whiteness: As a palliative, diuretic, antiperspirant, sedative, nourishing, mainly used as a tonic, increases digestive absorption, enhances liver function and body resistance, and is effective in chronic gastritis and gastric ulcers. It is prescribed when water accumulates in the joints;

구기자 : 소염작용, 자양강장작용, 간세포 신생 촉진작용을 한다;Gojija: anti-inflammatory, nourishing tonic, hepatic cell neoplasia;

강활 : 감기, 두통, 신경통, 관절염, 중풍 등에 효과가 있다;Active: It is effective for colds, headaches, neuralgia, arthritis, stroke, etc .;

율무 : 이뇨, 진통, 진경, 강장작용이 있으므로 부종, 신경통, 류머티즘, 방광결석 등에 사용된다;Yulmumu: Diuretic, analgesic, jingyeong, tonic because it is used for edema, neuralgia, rheumatism, bladder stones;

당귀 : 진통작용, 진정작용, 항균작용, 이뇨작용을 한다;Angelica: analgesic, sedative, antibacterial, diuretic;

오가피 : 강심, 진통작용을 하며 관절염 및 반신불수 치료에 효과적이다;Ogapi: strong heart, analgesic and effective in the treatment of arthritis and paraplegia;

황금 : 해열작용, 이뇨작용, 항균작용, 항바이러스작용, 한진균작용, 진정작용, 혈압강하작용을 하며, 항균 및 소염 작용도 있어 염증 및 부종 치료에 효과적이다;Golden: antipyretic, diuretic, antibacterial, antiviral, Korean fungal, sedative, blood pressure lowering, antibacterial and anti-inflammatory, effective for the treatment of inflammation and edema;

당삼 : 기력부강, 보혈작용, 강심작용을 하는 것으로서 자양보신의 효능이 있으므로 소화, 신경쇄약 증상에 사용하며 산후 기력보강에도 효과가 있다;Dangsam: strength and strength, blood action, cardiac action is the effect of yangyangbosin is used for digestion, nervous breakdown symptoms and postpartum energy reinforcement;

사인 : 건위작용, 소화촉진 작용, 소화기계통 질환에 효과가 뛰어나며 만성위염 및 장염에도 효과가 있다;Cause of death: Good for stomach, digestive, digestive disorders, also effective for chronic gastritis and enteritis;

산사 : 소화촉진작용, 혈관확장작용, 혈압강하작용을 하는 것으로서, 지방분해 효소가 있어 특히 육류소화에 특효과 있으며, 급성 및 만성 장염에 효과가 있다;Sansa: Promotes digestion, dilates blood pressure and lowers blood pressure. Lipolytic enzymes are particularly effective for meat digestion and are effective for acute and chronic enteritis;

목향 : 발한, 이뇨, 거담제로서 효과가 있다;Neck: effective as sweating, diuresis, expectorant;

생강 : 건위작용, 항균작용을 하는 것으로서, 감기 및 소화촉진, 식욕증진에 효과가 있고, 가스 배출을 촉진하며 세균성 이질 및 급성 장염, 간염 및 학질에도 효과가 있으며, 약독을 제거하는 기능이 있다;Ginger: It has the effect of health and antibacterial effect, promotes cold and digestion, appetite promotion, promotes gas release, is effective against bacterial dysentery and acute enteritis, hepatitis and school work, and eliminates poisoning;

우슬 : 진통작용, 혈압강하작용, 진경작용, 이뇨작용을 하는 것으로서, 통증을 멎게하고 어혈을 없애는데 효과가 있으며 좌골 신경통 및 관절염에 효과가 있고 소아마비 및 반신불수 치료에 효과가 있다;Wort: Analgesic, hypotensive, diuretic, diuretic, effective in relieving pain and eliminating bleeding, effective in treating sciatica and arthritis, and in treating polio and nephropathy;

상기 성분중, 주성분인 백출, 독활, 오가피, 두충, 당귀, 구기자, 강활, 우슬, 및 율무는 산제로 조제되는 것이 바람직한데, 그 이유는 산제로 조제한 약제는 주로 소염, 진통 및 항균작용을 하는 약제로서 직접적으로 관절염 및 신경통에 작용하는 것이므로 흡수 효과를 높히기 때문이다.Of the above components, the main components of baekchul, venom, oopi, worms, donkeys, goji berry, stalk, hyssop, and yulmu are preferably formulated as a powder, because the powdered drugs are mainly used for anti-inflammatory, analgesic and antibacterial activity. This is because the drug acts directly on arthritis and neuralgia, thereby enhancing absorption.

또한, 상기 성분중, 부성분인 황금, 산사, 목향, 사인, 생강, 및 당삼은 환제로 조제되는 것이 바람직한데, 그 이유는 환제로 조제한 약제는 주로 보혈, 보기, 소화촉진, 이뇨작용, 위 또는 간, 신장등을 보호하는 기능을 하는 보조제로서 환제로 조제할 경우 복용이 편리하며, 흡수속도가 산제에 비해 비교적 늦기 때문에 위에서 직접적으로 작용하고 약효과가 오래동안 지속되는 장점이 있을 뿐만 아니라, 산제의 효과를 보강하는 기능을 하기 때문이다.In addition, among the above components, the subsidiary ingredients golden, hawthorn, Mok-hyang, cod, ginger, and ginseng are preferable to be prepared by the pill, because the drug prepared by the pill is mainly blood, bog, digestion, diuretic, stomach or It is a supplement that functions to protect the liver, kidneys, etc. It is convenient to take when prepared as a pill, and because the absorption rate is relatively slow compared to the powder, it works directly on the stomach and has a long-lasting effect. This is because it functions to reinforce the effect.

본원 발명의 생약제제를 복용하는 경우, 성인 1 일 복용량은 1 포 (중량 2.20 g 내지 2.30 g; 산제 및 환제의 혼합형태) 로 복용시간은 저녁 식후 1-2 시간후나 취침전에 복용하며, 복용할 때는 그냥 먹거나 미지근한 물에 풀어서 복용해도 되므로 복용이 간편하다.When taking the herbal preparation of the present invention, the daily dose of an adult is 1 packet (weight 2.20 g to 2.30 g; a mixture of powder and pills), and the time of taking is 1-2 hours after dinner or before bedtime. You can take it just by eating or lukewarm in water.

하기에 본 발명의 대표적인 제조예 및 시험예를 기술하나, 이것으로 본 발명의 범주를 한정하고자 하는 것은 아니다.Representative production examples and test examples of the present invention are described below, but this is not intended to limit the scope of the present invention.

제제예Formulation example

햇볕에 잘 건조된 백출, 독활, 오가피, 두충, 당귀, 구기자, 강활, 우슬, 율무, 황금, 산사, 목향, 사인, 생강, 당삼을 구입하여 고온 살균 과정을 거친 후, 주성분인 백출, 독활, 오가피, 두충, 당귀, 구기자, 강활, 우슬, 율무는 분쇄기를 사용하여 각기 분쇄하고 이들을 혼합하여 산제를 제조한다.Sun-dried baekchul, venom, oopi, tofu, Angelica, goji berry, vigor, hyssop, yulmu, golden, hawthorn, mokyang, cod, ginger, and ginseng, after high-temperature sterilization process, the main components of baekchul, venom, Cucumbers, tofu, Angelica, wolfberry, stalk, walnut, and yulmu are pulverized using a grinder and mixed to prepare a powder.

부성분인 황금, 산사, 목향, 사인, 생강, 당삼에는 밀풀을 혼합하여 접착성이 있게한 후, 환제형기로 지름 0.4 cm 크기의 원형으로 만들어 45 ℃ - 50 ℃ 의 건조기에 넣고 12 시간 정도 건조시켜 환제를 제조한다.After mixing waxy glue with subsidiary ingredients such as golden, hawthorn, scent, sine, ginger, and ginseng, make it into a circular shape with a diameter of 0.4 cm using a pilling machine and put it in a dryer at 45 ℃-50 ℃ for 12 hours. Prepare the pills.

1 일분 한포의 중량은 2.20 g 내지 2.30 g 으로써 산제와 환제가 혼합된 상태이다. 산제와 환제의 혼합비율은 산제의 중량은 1.75g - 1.80 g 이며 환제의 중량은 0.45 g - 0.50 g 이다.The weight of one pack per day is 2.20 g to 2.30 g, which is a state in which powder and pill are mixed. The mixing ratio of powder and pill is 1.75g-1.80g, and the weight of pill is 0.45g-0.50g.

시험예 1Test Example 1

35 세 남자 환자는 약 6 개월 동안 무릎이 붓고 통증이 있었다. 이 환자는 정형외과 치료를 받았으나, 약물 복용시에만 통증이 중지되었고, 또한 한약을 45 일 복용하였을 때도 효과가 없었다.The 35-year-old male patient had swelling and pain in the knee for about six months. The patient was treated with orthopedic surgery, but the pain was stopped only when taking the drug, and it was ineffective even when taking the Chinese medicine for 45 days.

이 환자는 본 발명의 생약제제를 7 일간 복용한 후, 통증이 없어지고 붓기도 빠졌으며, 부작용은 없었다고 하였다.The patient reported that after taking the herbal preparation of the present invention for 7 days, the pain disappeared, the swelling disappeared, and there were no side effects.

시험예 2Test Example 2

47 세 여자 환자는 40 대 초반 부터 양 무릎 관절과 손마디 관절의 통증이 생기기 시작하여 많이 걸으면 무릎이 붓고 아펐으며, 손 관절이 부어 손 모양이 제대로 나타나지 않았고, 아침에 일어나면 손이 뻣뻣해지며 건드릴 수 없을 정도로 통증이 있었다. 이환자는 칼슘 비타민제의 영양제를 복용하였으나 별 다른 효과가 없었고, 민간 요법도 하여 보았으나 이 역시 별다른 효과가 없었다.A 47-year-old woman began to experience pain in both knee and hand joints in her early 40s, and when she walked a lot, her knees became swollen and painful, her hand joints swollen and her hands didn't appear properly. It was painful enough to touch. The patient took nutritional supplements of calcium vitamin, but did not have any effect, and tried folk remedies, but also did not have any effect.

이 환자는 본 발명의 생약제제를 10 일간 복용한 후, 손의 붓기가 빠져 손 모양이 정상으로 돌아왔고, 손의 통증이 호전되었으며 부작용은 없었다고 하였다.The patient reported that after taking the herbal medicine of the present invention for 10 days, the swelling of the hand was returned to the normal shape, the pain in the hand was improved, and there were no side effects.

시험예 3Test Example 3

직업이 운전수인 56 세 남자 환자는 운전할 때마다 전기가 오는 듯한 증세가 가끔 있었다. 이환자는 파스로 치료하였으나 별다른 효과가 없었다.A 56-year-old male, whose job was a driver, sometimes had signs of electricity coming out every time he drove. The patient was treated with pars but had no effect.

이 환자는 본 발명의 생약제제를 5 일간 복용한 후, 증상이 없어졌으며, 부작용은 없었다고 하였다.The patient reported that after taking the herbal preparation of the present invention for 5 days, the symptoms disappeared and there were no side effects.

시험예 4Test Example 4

56 세 여자 환자는 50 대 초반부터 많이 걷거나 날씨가 흐리면 통증이 있었다. 이환자는 파스로 치료하였으나 붙이고 있을 때만 통증이 없었고, 건강 보조 식품을 복용하여 보았으나 이 역시 별다른 효과가 없었다.A 56-year-old woman suffered from pain when she walked a lot or was cloudy in her early 50s. The patient was treated with pas but did not have pain only when he was wearing it.

이 환자는 본 발명의 생약제제를 23 일간 복용한 후, 통증이 조금 적어졌으며, 부작용은 없었다고 하였다.The patient reported that after taking the herbal medicine of the present invention for 23 days, the pain was slightly reduced and there were no side effects.

시험예 5Test Example 5

60 세 여자 환자는 40 대 후반 부터 양무릎에 통증이 생기기 시작하여 퇴행성 관절염으로 무릎 연골이 거의 닳아 없어진 상태이며 통증이 심하고 움직이기 힘들었다.The 60-year-old woman began to have pain in both knees in her late forties, and her knee cartilage was almost worn out due to degenerative arthritis.

이 환자는 본 발명의 생약제제를 10 일간 복용한 후, 통증이 조금 적어졌으며, 부작용은 없었다고 하였다.The patient reported that after taking the herbal preparation of the present invention for 10 days, the pain was slightly reduced and there were no side effects.

시험예 6Test Example 6

63 세 남자 환자는 50 대 중반 부터 어깨 및 양쪽 무릎의 통증이 심했다. 이환자는 각종 영양제 및 파스를 사용하였으나 별다른 효과가 없었다.A 63-year-old male had severe pain in the shoulders and knees since her mid-50s. The patient used various nutrients and pastes, but there was no effect.

이 환자는 본 발명의 생약제제를 15 일간 복용한 후, 통증이 현저하게 감소하였고, 부작용은 없었다고 하였다.The patient reported that after taking the herbal preparation of the present invention for 15 days, the pain was significantly reduced and there were no side effects.

시험예 7Test Example 7

66 세 남자 환자는 50 대 초반 부터 어깨, 허리, 목, 팔, 무릎에 통증이 생기기 시작하여 처음에는 좌골 신경통 발병, 허리 디스크, 어깨가 결리고 뒷목 통증으로 목을 좌우로 돌리지 못하였으며, 무릎은 가끔 통증이 있었고, 6 개월 전 부터는 손목도 결렸으며, 취침시에는 목뒤가 바늘로 찌르는 듯한 통증이 있었다. 이환자는 진통제, 파스등을 사용하였으나 별다른 효과가 없었고, 민간 요법으로 지네를 복용하여 보았으나 이 역시 별다른 효과가 없었다.A 66-year-old man began to have pains in his shoulders, back, neck, arms and knees in his early 50's. I had pain, and my wrist was six months ago, and when I went to bed, I had a needle-like pain in my back. Patients used painkillers and pars, but they did not have any effect, and they took centipedes as a folk remedy, but this also did not have any effect.

이 환자는 본 발명의 생약제제를 10 일간 복용한 후, 목뒤 통증 및 어깨 부위 통증이 다소 호전되었고 고개도 약간 움직일 수 있게 되었으며, 부작용은 없었다고 하였다.The patient reported that after taking the herbal medicine of the present invention for 10 days, the pain in the back of the neck and the shoulder area was somewhat improved, the head was able to move slightly, and there were no side effects.

시험예 8Test Example 8

72 세 여자 환자는 60 대 초반 부터 무릎이 붓고 통증이 있었다. 이환자는 병원약, 뼈주사등으로 치료 받았으나 별효과가 없었고, 쑥뜸, 침등의 민간 요법으로 치료를 해보았으나 이 역시 별 다른 효과가 없었다.A 72-year-old woman had swelling and pain in her knees in her early 60s. The patient was treated with hospital medications, bone injections, etc., but it did not have any effect. The patients were treated with folk remedies such as moxibustion and acupuncture.

이 환자는 본 발명의 생약제제를 15 일간 복용한 후, 무릎 통증이 호전되었고, 붓기가 가라앉았으며, 부작용은 없었다고 하였다.The patient reported that after taking the herbal preparation of the present invention for 15 days, the knee pain improved, the swelling subsided and there were no side effects.

시험예 9Test Example 9

80 세 여자 환자는 60 대 초반 부터 양 무릎에 통증이 생기기 시작하여, 연골이 모두 파괴된 상태로서 걷는데 매우 불편하고, 바깥 출입을 혼자 힘으로 거의 할 수 없었으며, 밤에 통증으로 인해 숙면이 불가능하였고, 무릎을 구부릴 수 없었으며, 다리가 앞으로 구부러지고 옆으로 휘어진 상태였다. 이환자는 각종 패취제, 칼슘 영양제, 뼈주사, 강한 진통제등으로 치료 받아 보았으나, 뼈주사나 진통제로 인한 부작용만 생겼고, 각종 패취제나 영양제는 별다른 효과가 없었다. 민간요법으로 홍화씨 가루, 닭, 오리, 달팽이, 산덩굴/뿌리등 약재, 벌침, 쑥뜸, 찜질, 부항등을 하여 보았으나 이역시 별다른 효과가 없었다. 그후, 오른쪽 무릎을 수술하였으며, 수술한 오른쪽 무릎은 통증은 없어졌고, 걷는데 편하였지만,왼쪽의 통증이 심각한 상태였다.The 80-year-old woman began to have pain in both knees in her early 60's, and was very uncomfortable to walk with all the cartilage destroyed. She could hardly go outside alone, and she could not sleep well at night due to pain. He could not bend his knees and had his legs bent forward and bent to the side. The patient was treated with various patches, calcium nutrients, bone injections, and strong analgesics, but only side effects from bone injections and analgesics occurred, and various patches and nutrients had no effect. As folk remedies, safflower seed, chicken, duck, snail, mountain vines / roots, herbs, bee sting, moxa, poultice, cupping, etc. were tried. Thereafter, the right knee was operated, and the right knee was painless and comfortable to walk, but the pain on the left was serious.

이 환자는 본 발명의 생약제제를 10 일간 복용한 후, 통증이 감소되어 밤에 숙면이 가능하게 되었고, 계단 오르내리는데 큰 불편이 없었다. 복용 18 일 후에는 비교적 장거리도 걸어 다닐 수 있었고, 통증이 감소하여 왼쪽 무릎 수술을 마져 하지않아도 되었으며, 부작용은 없었다고 하였다.After the patient took the herbal medicine of the present invention for 10 days, the pain was reduced to enable a good night's sleep, and there was no great discomfort in climbing up and down the stairs. After 18 days of treatment, she was able to walk relatively long distances, and the pain was reduced so that she had to complete the left knee surgery and there were no side effects.

상기 시험예 1 내지 9 는 본 발명의 생약제제가 생약으로서 부작용이 없으며, 남여 성별구분 및 체질에 따른 영향이 거의 나타나지 않고, 기타 질병 (고혈압, 당뇨) 등 노인성 질환을 가지고 있는 사람에게도 영향이 없으며, 기타 다른 질병약의 복용중에 본 발명의 생약제제를 같이 복용해도 부작용이 전혀없이 관절염, 특히 퇴행성 관절염 및 류마티스 관절염을 포함하는 관절염을 치료할 수 있다는 것을 나타낸다.Test Examples 1 to 9 have no side effects as the herbal medicine of the present invention as a herbal medicine, little effect according to gender classification and constitution of male and female, there is no effect on people with senile diseases such as other diseases (hypertension, diabetes), It is shown that taking the herbal preparation of the present invention together with other disease drugs can treat arthritis, especially arthritis including degenerative arthritis and rheumatoid arthritis, without any side effects.

본 발명의 생약제제는 (i) 주성분인 백출, 독활, 오가피, 두충, 당귀, 구기자, 강활, 우슬, 율무로 구성된 군에서 선택된 하나 이상의 성분 및 (ii) 부성분인 황금, 산사, 목향, 사인, 생강, 당삼으로 구성된 군에서 선택된 하나 이상의 성분을 함유하는 것으로서, 효과가 복합적이며, 부작용이 없고, 부성분이 공존하고 있기 때문에 주성분의 흡수가 완화되어 작용이 지속적으로 나타날 뿐만 아니라, 복용이 간편하여 관절염, 특히 퇴행성 관절염 및 류마티스 관절염을 포함하는 관절염을 효과적으로 치료할 수 있다.The herbal preparations of the present invention may include (i) one or more ingredients selected from the group consisting of baekchul, venom, staphylococcus aureus, tofu, Angelica, goji berry, rosacea, dew, and jujuk as main ingredients, and (ii) golden, hawthorn, scented, sine, It contains one or more ingredients selected from the group consisting of ginger and ginseng. Its effect is complex, there are no side effects, and the coexistence of side ingredients reduces the absorption of the main ingredients, resulting in continuous action and simple taking of arthritis. And especially arthritis including degenerative arthritis and rheumatoid arthritis.

Claims (2)

생약제제의 전체 중량을 기준으로, (i) 백출, 독활, 오가피, 두충, 당귀, 구기자, 강활, 우슬, 율무로 구성된 군에서 선택된 1 종 이상의 주성분 55 내지 90 %, 및 (ii) 황금, 산사, 목향, 사인, 생강, 당삼으로 구성된 군에서 선택된 1 종 이상의 부성분 10 내지 45 % 를 함유하는 관절염 치료용 생약제제.Based on the total weight of the herbal preparation, 55 to 90% of one or more active ingredients selected from the group consisting of: (i) baekchul, venom, staghorn, tofu, Angelica, wolfberry, vigor, oleace, jujum, and (ii) golden, hawthorn Herbal medicine for the treatment of arthritis, containing 10 to 45% of one or more subcomponents selected from the group consisting of, mokyang, sine, ginger, and ginseng. 제 1 항에 있어서, 주성분은 산제 형태이며, 부성분은 환제 형태인 생약제제.The herbal preparation according to claim 1, wherein the main ingredient is in powder form and the minor ingredient is in pill form.
KR1020010006440A 2001-02-09 2001-02-09 A herb medicine for treating an arthritis KR20020066242A (en)

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Publication number Priority date Publication date Assignee Title
WO2007007958A1 (en) * 2005-07-08 2007-01-18 Yuhan Corporation Herbal pharmaceutical composition for regenerative agent of cartilaginous tissue and treatment of osteoarthritis
KR100870893B1 (en) * 2007-04-25 2008-11-28 주식회사 동원에프앤비 A health care composition comprising eleutheroside B for the prevention and alleviation of bone disease
CN103127258A (en) * 2012-12-09 2013-06-05 延安大学附属医院 Traditional Chinese medicine for treating rheumatic arthritis
CN107233379A (en) * 2017-06-27 2017-10-10 广州智润生物制药科技有限公司 It is a kind of to treat Chinese medicine preparation of rheumatic arthritis and preparation method thereof
KR20190121642A (en) * 2018-04-18 2019-10-28 대전대학교 산학협력단 Pharmaceutical composition for improving arthritis and manufacturing method thereof

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JPH0873369A (en) * 1994-09-01 1996-03-19 Fuairudo:Kk Tea for health
KR20000053988A (en) * 2000-05-16 2000-09-05 신준식 Pharmacolocial effect and extracting method for osteoporosis and rhematoid arthritis treatment by constituent drugs of oriental medicine
KR20000054393A (en) * 2000-06-03 2000-09-05 신준식 Pharmacolocial effect and extracting method for chronic osteoporosis and rhematoid arthritis treatment by constituent drugs of oriental medicine
KR20010084485A (en) * 2000-02-25 2001-09-06 정두순 Method of preparing herbal relievers for neuralgia and arthritis.

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JPH06293653A (en) * 1993-02-01 1994-10-21 Tsumura & Co Antirheumatic agent
JPH0873369A (en) * 1994-09-01 1996-03-19 Fuairudo:Kk Tea for health
KR20010084485A (en) * 2000-02-25 2001-09-06 정두순 Method of preparing herbal relievers for neuralgia and arthritis.
KR20000053988A (en) * 2000-05-16 2000-09-05 신준식 Pharmacolocial effect and extracting method for osteoporosis and rhematoid arthritis treatment by constituent drugs of oriental medicine
KR20000054393A (en) * 2000-06-03 2000-09-05 신준식 Pharmacolocial effect and extracting method for chronic osteoporosis and rhematoid arthritis treatment by constituent drugs of oriental medicine

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007007958A1 (en) * 2005-07-08 2007-01-18 Yuhan Corporation Herbal pharmaceutical composition for regenerative agent of cartilaginous tissue and treatment of osteoarthritis
KR100870893B1 (en) * 2007-04-25 2008-11-28 주식회사 동원에프앤비 A health care composition comprising eleutheroside B for the prevention and alleviation of bone disease
CN103127258A (en) * 2012-12-09 2013-06-05 延安大学附属医院 Traditional Chinese medicine for treating rheumatic arthritis
CN107233379A (en) * 2017-06-27 2017-10-10 广州智润生物制药科技有限公司 It is a kind of to treat Chinese medicine preparation of rheumatic arthritis and preparation method thereof
KR20190121642A (en) * 2018-04-18 2019-10-28 대전대학교 산학협력단 Pharmaceutical composition for improving arthritis and manufacturing method thereof

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