CN103127353A - Pharmaceutical composition for treating rheumatoid arthritis - Google Patents
Pharmaceutical composition for treating rheumatoid arthritis Download PDFInfo
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- CN103127353A CN103127353A CN 201110373793 CN201110373793A CN103127353A CN 103127353 A CN103127353 A CN 103127353A CN 201110373793 CN201110373793 CN 201110373793 CN 201110373793 A CN201110373793 A CN 201110373793A CN 103127353 A CN103127353 A CN 103127353A
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Abstract
The invention relates to a pharmaceutical composition for treating rheumatoid arthritis. The invention is developed based on traditional Chinese medicine basic theory, and comprises traditional Chinese medicine raw material herbs of radix angelicae pubescentis, notopterygium roots, radices sileris, angelica, white peony roots, radix aconiti preparata, prepared kusnezoff monkshood roots, parasitic loranthus, eucommia, rhizoma dioscoreae nipponicae, peach kernels, safflower, ligusticum wallichii, radix angelicae, licorice, etc. The pharmaceutical composition of the invention has the efficacy of nourishing blood, relaxing muscles and tendons, dispelling wind, eliminating dampness, removing rheumatism, and relieving pain, and is used for treating rheumatoid arthritis clinically.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of rheumatoid arthritis, say that more specifically a kind of tonifying the blood and stretching the tendon, expelling wind and removing dampness, eliminating impediment pain relieving effect are to treat the pharmaceutical composition of rheumatoid arthritis.Belong to field of medicaments.
Background technology
Rheumatoid arthritis (Rheumatoid arthritis. RA) is symmetric multi-joint chronic inflammatory disease around main manifestations, autoimmune disease.Sickness rate in China is 0.32%-0.34%.American-European white man's sickness rate is 1%-2%.China's some areas prevalence is at 0.4%-1.0%.Primary disease is to cause population of China disability and one of Etiological of disabling.Its cause of disease and pathogenesis are not clear, and the course of disease is long, and treatment is difficult, and disability rate is high, and any age all can fall ill, the most common with 25-55 year, women's morbidity is higher than male 2-3 times.Its clinical disease course differs, approximately alleviates after 15% single episode, and 25% intermittent attack, 50% persistence outbreak makes progress into rapidly serious symptom person and accounts for 10%.Have a strong impact on patients ' life quality, cause difficulty to family, bring burden to society.
For a long time, Chinese scholars has been made multi-level, multi-sided a large amount of research work to the primary disease Therapeutic Method, and method is a lot, and internal treatment, external treatment, combination of inner and outside treatment etc. are arranged.Endo-medicine is one of main method for the treatment of at present RA, and commonly used have non-hormone anti-inflammatory agent, hormone medicine, Chinese medicine and other medicines etc.Non-hormone anti-inflammatory agent (NSAIDS) is the common drug for the treatment of rheumatoid arthritis, and its anti-inflammatory and analgesic effect is strong, but untoward reaction is more, and is especially large to the gastrointestinal toxic and side effects, the unsuitable prolonged application of patient.The hormone medicine antiinflammatory action is powerful, can alleviate rapidly RA patient's symptom.But a large amount of data show, it can not block course advancement and the carrying out property destruction of joint of RA, and the harm of the side effect that produces of prolonged application and iatrogenic disease and be not less than even harm greater than RA itself.Therefore, the use of hormone in RA greatly reduces.Therefore some immunosuppressant also is used to treat RA, but this class medicine is all nonspecific to rheumatism, and toxicity is larger, is applicable to generally that other medicine for rheumatisms are invalid or the state of an illness is heavier and necessary information.The Chinese herb triperygium wilfordii preparation can be alleviated the symptom of RA effectively, but toxic and side effects is also a lot, mainly contain menoxenia, menolipsis, atrophy of testis, sperm atrophy, sperm quantity minimizing and gastrointestinal reaction, as nauseating, vomiting, xerostomia, stomatitis etc., acute agranulocytosis can appear in the severe allergy person.
Medicine base of the present invention take " tonifying the blood and stretching the tendon, expelling wind and removing dampness, eliminating impediment pain relieving " as the Therapeutic Principle, through systematic study, science compatibility, has been developed a kind of pure Chinese medicine for the treatment of rheumatoid arthritis with Chinese medical theory.
Summary of the invention
Purpose of the present invention just is to provide a kind of pharmaceutical composition for the treatment of rheumatoid arthritis.
For achieving the above object, the pharmaceutical composition for the treatment of rheumatoid arthritis provided by the invention is prepared from by the processing of the crude drug of following weight parts:
Radix Angelicae Pubescentis 10-15 part Rhizoma Et Radix Notopterygii 8-12 part Radix Saposhnikoviae 8-12 part Radix Angelicae Sinensis 8-12 part
Radix Paeoniae Alba 8-12 part Radix Aconiti Preparata 1-3 part Radix Aconiti Kusnezoffii Preparata 1-3 part Herba Taxilli 10-15 part
Cortex Eucommiae 10-15 part Rhizoma Dioscoreae Nipponicae 5-8 part Semen Persicae 8-12 part Flos Carthami 8-12 part
Rhizoma Chuanxiong 5-8 part Radix Angelicae Dahuricae 8-12 part Radix Glycyrrhizae 10-15 part;
Preferred plan is prepared from by the processing of the crude drug of following weight parts:
10 parts of 10 parts of Radix Angelicae Sinensis of 10 parts of Radix Saposhnikoviaes of 12 portions of Rhizoma Et Radix Notopterygiis of Radix Angelicae Pubescentis
12 parts of 2 parts of Herba Taxillis of 2 parts of Radix Aconiti Kusnezoffii Preparatas of 10 parts of Radix Aconiti Preparatas of the Radix Paeoniae Alba
10 parts, 10 parts of Flos Carthamis of 6 parts of Semen Persicaes of 12 portions of Rhizoma Dioscoreae Nipponicae of the Cortex Eucommiae
12 parts, 10 portions of Radix Glycyrrhizaes of 6 parts of Radixs Angelicae Dahuricae of Rhizoma Chuanxiong
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis of the present invention can be prepared into the clinical applicable dosage forms such as capsule, tablet, granule.
Why the present invention selects above-mentioned medical material as raw material, is because they have following effect:
Radix Angelicae Pubescentis: expelling wind and removing dampness, numbness relieving and pain relieving.Be used for anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.
Rhizoma Et Radix Notopterygii: cold expelling, dispel the wind, dehumidifying, pain relieving.Be used for the anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.
Radix Saposhnikoviae: inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.Be used for headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
The Radix Paeoniae Alba: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Be used for having a headache dizzy, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Radix Aconiti Preparata: expelling wind and removing dampness, antalgic.Be used for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Radix Aconiti Kusnezoffii Preparata: expelling wind and removing dampness, antalgic.Be used for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Herba Taxilli: invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.Be used for rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and the metrorrhagia warp is many, blood leaking in gestation, frequent fetal movement; Vascular hypertension.
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Be used for lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Vascular hypertension.
Rhizoma Dioscoreae Nipponicae: relaxing muscles and tendons to promote blood circulation, relieving cough and resolving phlegm, wind-expelling pain-stopping.Be used for lumbago and skelalgia, rheumatalgia, rheumatic arthritis, muscles and bones numbness, Kaschin-Beck disease, traumatic injury, sprain one's back, cough pant, tracheitis, bronchitis.
Semen Persicae: activating blood circulation and dissipating phlegm, loosening bowel to relieve constipation.Be used for amenorrhea, dysmenorrhea, enemy mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Flos Carthami: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
The Radix Angelicae Dahuricae: loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.Be used for headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Pharmaceutical composition provided by the invention has the effect of tonifying the blood and stretching the tendon, expelling wind and removing dampness, eliminating impediment pain relieving, is used for the treatment of rheumatoid arthritis.
Clinical case:
Zhang, man, 47 years old, cadre.First visit in October, 2008, main suit's two finger-joint pain 10 years, night is more very.Right lower limb more than 2 years from hip to vola pain, the pain increased in recent years, can not walk.Once arrived nonlocal diagnosis and treatment invalid.Send out cool in patient's self-induction bone, and from hip to the vola numb pain.Each slowly walk 10 minutes less than, namely hurt like hell, squat down rapidly and relax, and sees its right leg muscle atrophy, color of the leather is withered sallow, surveys its two lower limb week difference not to be: the poor 1cm of ankle, the gastrocnemius CHENGSHAN acupoint poor 1.7cm in place, 5 cun poor 2.7cm on patella.And with the abdominal distention poor appetite, limbs are tired heavy, and two eye socket darkness are remarkable.The body of the tongue stasis of blood is dim, tongue is white thick greasy, and thready pulse is little puckery.Be diagnosed as the cold-damp arthromyodynia.In order to prescription drug of the present invention after two weeks, two fingers swell and ache and subdue, then take after two weeks an external malleolus and upper 5 cun and still have pain, and diet is as usual, and the eye socket darkness turns light.The state of an illness is controlled, and takes a turn for the better gradually, is aided with the other drug treatment and is almost recovered January.
The specific embodiment
Below with embodiment, a kind of pharmaceutical composition for the treatment of rheumatoid arthritis of the present invention is further described; this will help the present invention and effect thereof are further understood; embodiment does not limit protection scope of the present invention, and its protection domain is decided by claim.
Embodiment 1
8 parts of 8 parts of Radix Angelicae Sinensis of 8 parts of Radix Saposhnikoviaes of 10 portions of Rhizoma Et Radix Notopterygiis of Radix Angelicae Pubescentis
10 parts of 1 part of Herba Taxillis of 1 part of Radix Aconiti Kusnezoffii Preparata of 8 parts of Radix Aconiti Preparatas of the Radix Paeoniae Alba
8 parts, 8 parts of Flos Carthamis of 5 parts of Semen Persicaes of 10 portions of Rhizoma Dioscoreae Nipponicae of the Cortex Eucommiae
10 parts, 8 portions of Radix Glycyrrhizaes of 5 parts of Radixs Angelicae Dahuricae of Rhizoma Chuanxiong
Embodiment 2
12 parts of 12 parts of Radix Angelicae Sinensis of 12 parts of Radix Saposhnikoviaes of 15 portions of Rhizoma Et Radix Notopterygiis of Radix Angelicae Pubescentis
15 parts of 3 parts of Herba Taxillis of 3 parts of Radix Aconiti Kusnezoffii Preparatas of 12 parts of Radix Aconiti Preparatas of the Radix Paeoniae Alba
12 parts, 12 parts of Flos Carthamis of 8 parts of Semen Persicaes of 15 portions of Rhizoma Dioscoreae Nipponicae of the Cortex Eucommiae
15 parts, 12 portions of Radix Glycyrrhizaes of 8 parts of Radixs Angelicae Dahuricae of Rhizoma Chuanxiong
Embodiment 3
10 parts of 10 parts of Radix Angelicae Sinensis of 10 parts of Radix Saposhnikoviaes of 12 portions of Rhizoma Et Radix Notopterygiis of Radix Angelicae Pubescentis
12 parts of 2 parts of Herba Taxillis of 2 parts of Radix Aconiti Kusnezoffii Preparatas of 10 parts of Radix Aconiti Preparatas of the Radix Paeoniae Alba
10 parts, 10 parts of Flos Carthamis of 6 parts of Semen Persicaes of 12 portions of Rhizoma Dioscoreae Nipponicae of the Cortex Eucommiae
12 parts, 10 portions of Radix Glycyrrhizaes of 6 parts of Radixs Angelicae Dahuricae of Rhizoma Chuanxiong.
Claims (3)
1. pharmaceutical composition for the treatment of rheumatoid arthritis is characterized in that being prepared from by the crude drug processing of following weight parts:
Radix Angelicae Pubescentis 10-15 part Rhizoma Et Radix Notopterygii 8-12 part Radix Saposhnikoviae 8-12 part Radix Angelicae Sinensis 8-12 part
Radix Paeoniae Alba 8-12 part Radix Aconiti Preparata 1-3 part Radix Aconiti Kusnezoffii Preparata 1-3 part Herba Taxilli 10-15 part
Cortex Eucommiae 10-15 part Rhizoma Dioscoreae Nipponicae 5-8 part Semen Persicae 8-12 part Flos Carthami 8-12 part
Rhizoma Chuanxiong 5-8 part Radix Angelicae Dahuricae 8-12 part Radix Glycyrrhizae 10-15 part.
2. a kind of pharmaceutical composition for the treatment of rheumatoid arthritis according to claim 1 is characterized in that being prepared from by the crude drug processing of following weight parts:
10 parts of 10 parts of Radix Angelicae Sinensis of 10 parts of Radix Saposhnikoviaes of 12 portions of Rhizoma Et Radix Notopterygiis of Radix Angelicae Pubescentis
12 parts of 2 parts of Herba Taxillis of 2 parts of Radix Aconiti Kusnezoffii Preparatas of 10 parts of Radix Aconiti Preparatas of the Radix Paeoniae Alba
10 parts, 10 parts of Flos Carthamis of 6 parts of Semen Persicaes of 12 portions of Rhizoma Dioscoreae Nipponicae of the Cortex Eucommiae
12 parts, 10 portions of Radix Glycyrrhizaes of 6 parts of Radixs Angelicae Dahuricae of Rhizoma Chuanxiong.
3. one of them described a kind of pharmaceutical composition for the treatment of rheumatoid arthritis according to claim 1 and 2, is characterized in that, preparation is the clinical applicable dosage forms such as capsule, tablet, granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110373793 CN103127353A (en) | 2011-11-22 | 2011-11-22 | Pharmaceutical composition for treating rheumatoid arthritis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110373793 CN103127353A (en) | 2011-11-22 | 2011-11-22 | Pharmaceutical composition for treating rheumatoid arthritis |
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| CN103127353A true CN103127353A (en) | 2013-06-05 |
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| CN 201110373793 Pending CN103127353A (en) | 2011-11-22 | 2011-11-22 | Pharmaceutical composition for treating rheumatoid arthritis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524475A (en) * | 2015-01-16 | 2015-04-22 | 王绪彩 | Pharmaceutical preparation for rheumatoid arthritis |
| CN104547513A (en) * | 2014-12-22 | 2015-04-29 | 豆坤 | Enema traditional Chinese medicine preparation for treating rheumatoid arthritis |
| CN106377648A (en) * | 2016-11-15 | 2017-02-08 | 龙岩市中医院 | Decotion capable of strengthening waist, dredging collaterals and treating pain |
-
2011
- 2011-11-22 CN CN 201110373793 patent/CN103127353A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547513A (en) * | 2014-12-22 | 2015-04-29 | 豆坤 | Enema traditional Chinese medicine preparation for treating rheumatoid arthritis |
| CN104524475A (en) * | 2015-01-16 | 2015-04-22 | 王绪彩 | Pharmaceutical preparation for rheumatoid arthritis |
| CN106377648A (en) * | 2016-11-15 | 2017-02-08 | 龙岩市中医院 | Decotion capable of strengthening waist, dredging collaterals and treating pain |
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Application publication date: 20130605 |