CN104524475A - Pharmaceutical preparation for rheumatoid arthritis - Google Patents
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- CN104524475A CN104524475A CN201510022459.6A CN201510022459A CN104524475A CN 104524475 A CN104524475 A CN 104524475A CN 201510022459 A CN201510022459 A CN 201510022459A CN 104524475 A CN104524475 A CN 104524475A
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Abstract
The invention relates to a pharmaceutical preparation for rheumatoid arthritis. The pharmaceutical preparation is prepared from the following raw materials in parts by weight: 35 parts of ligusticum wallichii, 35 parts of notopterygium root, 35 parts of pawpaw, 30 parts of eucommia ulmoides, 30 parts of radix aconiti preparata, 25 parts of curcuma zedoary, 25 parts of dandelion, 25 parts of amomum tsao-ko, 25 parts of teasel root, 20 parts of pericarpium arecae, 20 parts of salvia miltiorrhiza, 20 parts of pollen typhae, 20 parts of hawthorn, 20 parts of smoked plum, 20 parts of mulberry, 15 parts of cinnamon, 15 parts of radix angelicae, 10 parts of myrrh, 10 parts of rhizoma drynariae, 10 parts of radix angelicae pubescentis, 10 parts of schisandra chinensis, 10 parts of herba epimedii, 10 parts of cassia twig, 10 parts of Caulis Spatholobi and 10 parts of polygonum cuspidatum. The pharmaceutical preparation treats both symptoms and root causes of the rheumatoid arthritis, is non-toxic and harmless to the human body, does not have any side effect, is low in price and easy and convenient to prepare and has wide application prospects.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical preparation for rheumatoid arthritis.
Background technology
Rheumatoid arthritis waits exopathogen invasion, impatency meridians joint because wind and cold is damp and hot, and QI-blood circulation is smooth, main clinical manifestation to be general joint be migrans red, swell, weigh, pain.The arthralgia of main clinical manifestation caused by Minor articulus synovial membrane, cartilage destruction, joint space narrow then, late period because of serious bone destruction, absorb cause joint stiffness, deformity, dysfunction.It is a kind of common frequently-occurring disease.Articular cavity synovial membrane inflammation, sepage, cell proliferation, Granuloma formation, cartilage and bone destruction, last ankylosis and dysfunction.Main infringement joint and heart, show as pain of joint muscle, and numb, swelling, red heat, can find autoantibody in serum, therefore thinks that primary disease is self property disease.Age of onset is many at 20 ~ 50 years old.Women is more than male.How rational use of drug, early stage symptom management progress, stops osteoarthrosis to destroy, has become the study hotspot outside Present Domestic.
At present, doctor trained in Western medicine is for the treatment of rheumatoid arthritis, and different opinions are respectively held one and said.There is what is called " classical pyramid " pattern; So-called " inverted pyramid pattern ", namely starts treatment and just uses strong medicine, as cytotoxic immune inhibitor etc. changes the antirheumatic of the state of an illness; So-called " leave from office stepwise ", namely starts to join platform " encirclings and suppressing " with multi-medicament, then composition of medicine is stopped using gradually respectively, finally selects a kind of effectively little medicine maintenance of side effect; So-called " wave pattern ", namely on a kind of medicine treatment basis, in addition interim treatment, gives when the state of an illness rises in fluctuation to strengthen treatment.Recover Primary Care again, so repeatedly later.
Motherland's medical science thinks that rheumatoid arthritis is because of void, heresy, expectorant, the stasis of blood, poison and cause, void is deficiency of the liver and kindey, deficiency of qi and blood is the intrinsic factor that rheumatoid arthritis is fallen ill, positive so-called " healthy energy exists; can not do; gathering of heresy, and its gas must be empty ", therefore suitable benefiting QI and nourishing blood, invigorating the kidney and strengthening the bones are with righting, dispel the wind, cold expelling, dehumidifying, heat clearing away with eliminating evil, hold concurrently with dredging collateral.
Large quantity research finds in recent years, some Chinese medicine and effective ingredient thereof have significant therapeutic effect to rheumatoid arthritis, achieve the achievement that some are gratifying, clinical report all obtains good curative effect, therefore seeks a kind of high-efficiency low-toxicity, the medicine for rheumatoid arthritis for the treatment of both the principal and secondary aspects of a disease is the technical barrier of pendulum in face of medical circle.
Summary of the invention
The object of the invention is the feature playing traditional Chinese medical science combination drug, across-the-board regulation bodily fuctions, provide a kind of expelling wind and cold, the pharmaceutical preparation for rheumatoid arthritis of eliminating dampness and dredging channels.
Rheumatoid arthritis belongs to " arthromyodynia " category in Chinese medicine, and theory of Chinese medical science is thought " numbness person, closes also, also obstructed ".In the pathogenic process of rheumatoid arthritis, wind, cold, wet, heat, silt are paathogenic factor.Rheumatoid arthritis is divided into four types by modern Chinese medicine, and the initial stage is that wind-cold damp pathogen invades joint meridians, caused by QI and blood is obstructed; Mid-term and acute attack stage are wet hot phlegm stasis of blood type, caused by damp and hot blockage of phlegm and blood stasis meridians, joint; Deficiency of both the liver and kidney type, be due to numbness disease with the passing of time, caused by deficiency of both the liver and kidney; QIXUELIANGXU type sees the late period of primary disease.The etiology and pathogenesis feature of development is there is with regard to rheumatoid arthritis conditions, especially with wind, cold, wet three kinds of pathogens are the most common, therefore interior " wet three gas of wind and cold are mixed to and are numbness through saying, its wind Sheng person is migratory arthralgia, cold Sheng person is arthralgia aggravated by cold, dampness Sheng person is damp arthralgia ", next is obstinate disease, prolonged illness becomes the stasis of blood, stasis blocking meridians form, it is the wet double obstruction of collaterals by blood stasis type arthromyodynia of clinical common wind and cold folder that we institute controls main symptom, its pathogenesis is that wind-cold damp pathogen invades human body, retardance meridians, with the passing of time QI-blood circulation is not smooth, give birth in blood stasis and hinder network, blockage of main and collateral channels, send out as arthromyodynia, therefore determine expelling wind and cold, eliminating dampness and dredging channels, the rule for the treatment of of promoting blood circulation and stopping pain.
Present inventor is according to forefathers' experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, seek therapeutic regimen, meticulously be mixed with the pharmaceutical preparation for the treatment of rheumatoid arthritis of the present invention in conjunction with Traditional Chinese Medicine technology, rheumatoid arthritis had to the effect of taking stopgap measures and effecting a permanent cure.
For achieving the above object, the technical solution used in the present invention is as follows:
For a pharmaceutical preparation for rheumatoid arthritis, it is prepared by the raw material of following weight proportioning and obtains:
Rhizoma Chuanxiong 35 parts, Rhizoma Et Radix Notopterygii 35 parts, Fructus Chaenomelis 35 parts, the Cortex Eucommiae 30 parts, Radix Aconiti Preparata 30 parts,
Rhizoma Curcumae 25 parts, Herba Taraxaci 25 parts, Fructus Tsaoko 25 parts, Radix Dipsaci 25 parts, Pericarpium Arecae 20 parts,
Radix Salviae Miltiorrhizae 20 parts, Pollen Typhae 20 parts, Fructus Crataegi 20 parts, Fructus Mume 20 parts, 20 parts, Fructus Mori,
Cortex Cinnamomi 15 parts, the Radix Angelicae Dahuricae 15 parts, Myrrha 10 parts, Rhizoma Drynariae 10 parts, Radix Angelicae Pubescentis 10 parts,
Fructus Schisandrae Chinensis 10 parts, Herba Epimedii 10 parts, Ramulus Cinnamomi 10 parts, Caulis Spatholobi 10 parts, Rhizoma Polygoni Cuspidati 10 parts.
The preparation method of described pharmaceutical preparation is:
(1) raw material is taken according to weight proportion;
(2) Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Fructus Tsaoko, Radix Dipsaci, Pericarpium Arecae, Radix Salviae Miltiorrhizae, Pollen Typhae, the Radix Angelicae Dahuricae, Myrrha, Rhizoma Drynariae, Radix Angelicae Pubescentis, Caulis Spatholobi, Rhizoma Polygoni Cuspidati are mixed according to described ratio, add 3 times of weight 90% alcohol dipping 24 hours, reflux, extract, twice, each 1 hour, merge extractive liquid, is condensed into the clear paste that density is 1.2 g/ml;
(3) residual components water boiling and extraction 2 times, first time extracts the water adding 5 times of weight, and extraction time is 1 hour; Second time extracts the water adding 2 times of weight, and extraction time is 1 hour; Filter, merging filtrate, is concentrated into the clear paste that density is 1.2 g/ml;
(4), after fully being mixed by clear paste prepared by step (2), step (3), soft capsule is pressed into encapsulating machine.
Technical solutions according to the invention are on the arthritic clinical experience basis of Chinese traditional treatment; the dialectical acquisition technical scheme of length in conjunction with many families; it has anti-inflammatory analgesic action very by force, can improve rapidly symptom, effectively control inflammation, and stops disease; Saving cortilage function; rheumatoid arthritis is had to effect of healing, overcome the slow and drug withdrawal of the prior art Chinese medicine onset easily side effect such as repeatedly, reach the object for the treatment of both the principal and secondary aspects of a disease; the each 0.2g of usage and dosage, twice on the one.
The dosage form reasonable recipe of medicine of the present invention, compatibility is simplified, and Therapeutic Principle hits rheumatismal morbidity pathogenesis, so determined curative effect, clinical practice reaction very well.Long-term taking does not have toxic and side effects, and raw material is of high quality and at a reasonable price to be easy to get.
Detailed description of the invention
Embodiment 1
For a pharmaceutical preparation for rheumatoid arthritis, it is prepared by the raw material of following weight proportioning and obtains:
Rhizoma Chuanxiong 35 parts, Rhizoma Et Radix Notopterygii 35 parts, Fructus Chaenomelis 35 parts, the Cortex Eucommiae 30 parts, Radix Aconiti Preparata 30 parts,
Rhizoma Curcumae 25 parts, Herba Taraxaci 25 parts, Fructus Tsaoko 25 parts, Radix Dipsaci 25 parts, Pericarpium Arecae 20 parts,
Radix Salviae Miltiorrhizae 20 parts, Pollen Typhae 20 parts, Fructus Crataegi 20 parts, Fructus Mume 20 parts, 20 parts, Fructus Mori,
Cortex Cinnamomi 15 parts, the Radix Angelicae Dahuricae 15 parts, Myrrha 10 parts, Rhizoma Drynariae 10 parts, Radix Angelicae Pubescentis 10 parts,
Fructus Schisandrae Chinensis 10 parts, Herba Epimedii 10 parts, Ramulus Cinnamomi 10 parts, Caulis Spatholobi 10 parts, Rhizoma Polygoni Cuspidati 10 parts.
The preparation method of described pharmaceutical preparation is:
(1) raw material is taken according to weight proportion;
(2) Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Fructus Tsaoko, Radix Dipsaci, Pericarpium Arecae, Radix Salviae Miltiorrhizae, Pollen Typhae, the Radix Angelicae Dahuricae, Myrrha, Rhizoma Drynariae, Radix Angelicae Pubescentis, Caulis Spatholobi, Rhizoma Polygoni Cuspidati are mixed according to described ratio, add 3 times of weight 90% alcohol dipping 24 hours, reflux, extract, twice, each 1 hour, merge extractive liquid, is condensed into the clear paste that density is 1.2 g/ml;
(3) residual components water boiling and extraction 2 times, first time extracts the water adding 5 times of weight, and extraction time is 1 hour; Second time extracts the water adding 2 times of weight, and extraction time is 1 hour; Filter, merging filtrate, is concentrated into the clear paste that density is 1.2 g/ml;
(4), after fully being mixed by clear paste prepared by step (2), step (3), soft capsule is pressed into encapsulating machine.
The each 0.2g of usage and dosage, twice on the one.
Embodiment 2
Effect experiment
The measurement of drug effect is by the swelling degree measuring sole and the counterweight compression weight that can bear.
By United States Patent (USP) 5,908,628 Freund's complete adjuvant intradermal injections bring out primary arthritis to the left back sole of every rat.Using aspirin as reference medicine (0.15 gram/kg).
Male rat is divided into 3 groups at random, often organizes 10, and single weight of each group is 160-170 gram, and measures the girth of rat hind paw.Inflammation is brought out to the left back sole of every rat with the intradermal injection of 0.1 milliliter of Freund adjuvant.After one week, completing of injection Freund adjuvant.Mouse feeding distilled water (matched group) respectively of each group, aspirin, or pharmaceutical composition of the present invention.3rd day, intradermal injection 0.1 milliliter of Freund adjuvant brought out inflammation, and measures inflammation swelling degree and compression capability after 2,4,6,24,48 and 72 hours.Result shows, pharmaceutical preparation of the present invention has obvious inhibitory action to inflammation and pain.In table 1
Table 1
Embodiment 3
Clinical data
Clinical data: be selected from outpatient's totally 110 examples with complete case.Be divided into treatment group 55 example at random, matched group 55 example.The treatment group age is 29-60 year; The matched group age in 30-61 year, age and the course of disease through X 2 test, without statistically-significant difference (p > 0.05).
Diagnostic criteria:
Western medicine diagnose standard: the diagnostic criteria with reference to rheumatism association of U.S. rheumatoid arthritis in 1989: 1. morning is stiff: joint and around stiff sense at least continue 1h (course of disease >=6 week); 2. the arthritis of more than 3 or 3 region joint parts: doctor observes in 14 regions (proximal interphalangeal joint on left side or right side, metacarpal joint, wrist, elbow, knee joint, ankle and metatarsophalangeal joints) and involves 3, and soft tissue swelling or hydrops (not being simple bone protuberance) (course of disease >=6 week) simultaneously; 3. cheirarthritis: wrist, the palm refer to or in proximal interphalangeal joint inflammation, have an arthroncus (course of disease >=6 week) at least; 4. symmetry arthritis: get involved in joint, both sides simultaneously (bilateral proximal interphalangeal joint, metacarpophalangeal joints and metatarsophalangeal joints are subject to for a long time, not necessarily absolute symmetry) (course of disease >=6 week); 5. rheumatoid nodules: doctor observes at apophysis position, and extensor surface or periarticular have subcutaneous nodule; 6. rheumatoid factor positive: any detection method proves that serum rheumatoid factor (SRF) content is abnormal, and the positive rate of the method in normal population is less than 5%; 7. radiology changes: the postero-anterior position of hands and wrist mutually on have typical rheumatoid arthritis radiology to change: must comprise bone erosion or affected joints and be close to position has clear and definite sclerotin decalcification.Above 7 meet more than 4 and get rid of other arthritis and can be diagnosed as rheumatoid arthritis.
Tcm diagnosis standard: 1. main clinical manifestation: the tract pain such as joint, skin, muscles and bones or swelling morning stiff, numbness weighs, joint stuffiness, even joint swelling deformation, tetanicly not stretch, amyotrophy etc.: 2. characteristics of incidence: how relevant with climate change; 3. sex, Age Characteristics: be apt to occur in person between twenty and fifty, female is more than man; 4. physico-chemical examination: rheumatoid factor positive or erythrocyte sedimentation rate speed, the visible bone erosion of x-ray.Possess above-mentioned 1., 4. two, can make a definite diagnosis in conjunction with 2. or 3. item.
Therapeutic Method: treatment group takes embodiment 1 useful in preparing drug formulations according to the method for the invention, treats 2 courses for the treatment of, 1 month each course for the treatment of;
Matched group adopts penicillin 8,000,000 U to add 0.9% sodium chloride injection 250ml intravenous drip, once a day, coordinates Dicolfanac Sodium Sustained Release Tablets 75mg oral, once a day, within one month, is 1 course for the treatment of, treats 2 courses for the treatment of.
Efficacy assessment standard: 1. cure: arthralgia, swelling disappear (index reduces >=90%), and movable function is normal, and lab testing is normal; 2. effective: arthralgia, swelling alleviate (index reduces 60% ~ 89%), and movable function takes a turn for the better, and lab testing take a favorable turn; 3. take a turn for the better: arthralgia, swelling alleviate to some extent (index reduces 31% ~ 59%), and movable function takes a turn for the better, and lab testing makes moderate progress; 4. invalid: arthralgia, swelling (index reduces≤30%) symptom and lab testing are without improvement.
Therapeutic outcome: two groups of therapeutic outcomes (P<0.01) as follows:
Group | Example time | Cure | Effective | Take a turn for the better | Invalid | Total effective rate |
Treatment group | 55 | 26 | 12 | 14 | 3 | 94.5% |
Matched group | 55 | 12 | 13 | 13 | 17 | 69.1% |
Can find out that medicine group of the present invention is than conventional therapy significant difference.
Above-mentioned each Chinese herbal medicine that the present invention adopts makes compatibility mutually, its collaborative effect of curing the disease can be played, there is between each composition of raw material of Chinese medicine used drug effect be interweaved and mutually promote and coordinate usefulness, through clinical verification, there is good therapeutic effect to rheumatoid arthritis, in the applicant's medical practice for many years, the case Numerous of curing, all obtain good effect, and with low cost, alleviate the burden of patient.
Claims (3)
1. for a pharmaceutical preparation for rheumatoid arthritis, it is characterized in that, described pharmaceutical preparation is prepared by the raw material of following weight proportioning and obtains:
Rhizoma Chuanxiong 35 parts, Rhizoma Et Radix Notopterygii 35 parts, Fructus Chaenomelis 35 parts, the Cortex Eucommiae 30 parts, Radix Aconiti Preparata 30 parts,
Rhizoma Curcumae 25 parts, Herba Taraxaci 25 parts, Fructus Tsaoko 25 parts, Radix Dipsaci 25 parts, Pericarpium Arecae 20 parts,
Radix Salviae Miltiorrhizae 20 parts, Pollen Typhae 20 parts, Fructus Crataegi 20 parts, Fructus Mume 20 parts, 20 parts, Fructus Mori,
Cortex Cinnamomi 15 parts, the Radix Angelicae Dahuricae 15 parts, Myrrha 10 parts, Rhizoma Drynariae 10 parts, Radix Angelicae Pubescentis 10 parts,
Fructus Schisandrae Chinensis 10 parts, Herba Epimedii 10 parts, Ramulus Cinnamomi 10 parts, Caulis Spatholobi 10 parts, Rhizoma Polygoni Cuspidati 10 parts.
2. pharmaceutical preparation according to claim 1, is characterized in that, the preparation method of described pharmaceutical preparation comprises the steps:
(1) each raw material for standby is taken according to weight proportion;
(2) Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Fructus Tsaoko, Radix Dipsaci, Pericarpium Arecae, Radix Salviae Miltiorrhizae, Pollen Typhae, the Radix Angelicae Dahuricae, Myrrha, Rhizoma Drynariae, Radix Angelicae Pubescentis, Caulis Spatholobi, Rhizoma Polygoni Cuspidati is got, mixing, add 3 times of weight 90% alcohol dipping 24 hours, reflux, extract, twice, each 1 hour, merge extractive liquid, is condensed into the clear paste that density is 1.2 g/ml;
(3) get surplus stock, by water boiling and extraction 2 times, first time extracts the water adding 5 times of weight, and extraction time is 1 hour; Second time extracts the water adding 2 times of weight, and extraction time is 1 hour; Filter, merging filtrate, is concentrated into the clear paste that density is 1.2 g/ml;
(4) clear paste prepared by clear paste step (2) prepared and step (3) fully mixes and get final product.
3. the pharmaceutical preparation described in claim 1-2 is used for the purposes of rheumatoid arthritis.
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