CN102293853B - Chinese medicinal pills for treating Bi syndrome - Google Patents
Chinese medicinal pills for treating Bi syndrome Download PDFInfo
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Abstract
The invention relates to Chinese medicinal pills for treating Bi syndrome. The Chinese medicinal pills are prepared from the following raw materials in part by weight: 10 to 30 parts of epimedium herb, 10 to 30 parts of cistanche, 10 to 20 parts of rhizoma drynariae, 10 to 20 parts of root of bidentate achyranthes, 10 to 20 parts of eucommia, 10 to 15 parts of root of red-rooted salvia, 6 to 12 parts of Chinese angelica, 6 to 9 parts of ligusticum wallichii, 6 to 9 parts of phellodendron, 5 to 9 parts of cassia twig and 5 to 15 safflower. The Chinese medicinal pills can be used for treating traditional Chinese medicinal differentiation liver and kidney yang deficiency Bi syndromes such as neck, waist, and leg aching pain, anchylosis and dysarthrasis, stretch disadvantage, limb numbness, fatigue and weakness, chilly sensation and cold limbs, chest distress and labored breathing and the like.
Description
Invention field
The present invention relates to a kind of medicine pill for the treatment of arthromyodynia, belong to the field of Chinese medicines.
Background technology
The arthromyodynia of the tradition traditional Chinese medical science or be called the numbness disease now unifiedly is called traditional Chinese medical science rheumatism, refers to because human body battalion defends imbalance, and the heresy of the damp and hot poison that is affected by the cold is closed and is disease; Or because with the passing of time human body weakened body resistance, interior turbid, the blood stasis, scorchingly hot of expectorant of giving birth to, good and evil are fought mutually, make meridians, skin, blood vessels, muscles and bones, even the QI and blood numbness of internal organs resistance, lose in moistening foster, and occur with limbs joint myalgia, swelling, miserable, numb, weighing, symptoms such as distortion, stiff, joint stuffiness, limitation of activity are feature, even involve the general name of a class disease of internal organs." numbness person closes also " is with skin and flesh arteries and veins muscles and bones, even the meridian qi and blood of internal organs " obstructed " or " not flourish " are main pathogenesis.Owing to logical, the general character of Rong Ze pain not of general rule is not arranged, so be referred to as arthromyodynia, is similar to the said rheumatism of modern medicine (abbreviation rheumatism).Rheumatism has characteristics gradual and that show effect repeatedly, is frequently-occurring disease, commonly encountered diseases clinically.
Rheumatism more seriously may cause joint tissue (as synovial membrane, tendon, ligament, cartilage, bone) infringement, distortion except causing symptom such as arthralgia, cause the limb activity dysfunction, even disabled bed.So, how effectively to protect joint tissue, prevent that joint tissue from too early or excessive destruction being taken place, be an emphasis in the rheumatism treatment process, also be a difficult point.At present, rheumatism has become the highest disease of disability rate, and WHO also therefore being defined as " joint, world buring sun " annual October 12, pays close attention to articulation health to remind national governments and the common people.
Chinese medicine is thought " kidney governing bones, liver governing tendons ", and Liver and kidney has decisive role for the normal physiological function of muscles and bones, and the muscles and bones infringement also has substantial connection with caused by liver and kidney deficiency." kidney storing essence, main bone is given birth to marrow.The then weak bone marrow sky of suffering from a deficiency of the kidney, can not Shugu and sharp joint also ".The liver and the kidney have a common source, and deficiency of kidney-essence then can not grow the liver-yin liver blood.Liver governing tendons, liver body deficiency then can not be grown flourish muscle tendon, so that the clonic spasm of the muscle arthralgia.Pathogen is taken advantage of a weak point, and the impatency meridians more make slight illness increase the weight of, and podomere is useless to be rheumatism involving the bone with sending out.
In arthromyodynia generation, evolution, blood stasis both can be the cause of disease, can be again pathological product.Arthromyodynia have the course of disease long, be difficult to the thoroughly characteristics of radical cure, Chinese medicine is thought " prolonged illness must the stasis of blood ", blood stasis can block meridians, causes that arthromyodynia takes place, development, and accelerates muscles and bones destruction, progressively causes podomere give up usefulness even disabled the bed.
The treatment rheumatism, modern medicine has four big class medicines: NSAID (non-steroidal anti-inflammatory drug), 17-hydroxy-11-dehydrocorticosterone, immunosuppressant, biological preparation.These medicines can alleviate the patients acuity symptom of stage of attack to a certain extent, can better control the state of an illness.But rheumatism is outbreak repeatedly easily, needs long-term prescription, so the toxic and side effects of various medicines has to cause enough attention.At aspects such as alleviating pain, antiinflammatories positive effect is arranged as nonsteroidal antiinflammatory drug, but the side effect of its gastrointestinal reaction is more common, such as nausea and vomiting, loss of appetite, even gastric ulcer, hemorrhage, perforation etc. take place; Nonsteroidal antiinflammatory drug causes the seriousness of heart damage also more and more to cause medical expert's attention; The Liver and kidney toxicity of nonsteroidal antiinflammatory drug also can not be ignored.The toxic and side effects of other three classes Western medicine is even more serious, common has: gastrointestinal reaction, hepatic and renal function injure, reproductive function infringement, hemopoietic function inhibition, endocrine regulation, bring out infection, induced osteoporosis etc., wherein the consequence that causes of life-time service hormone is even more serious, such as: femur head necrosis, osteoporosis, diabetes, endocrine regulation etc.
The tradition Chinese herbal medicine is having better curative effect aspect the treatment arthromyodynia, such as Radix Tripterygii Wilfordii, Tripterygium hypoglaucum, Caulis Sinomenii, black graceful (Tripterygium regelii Spragus et Takeda), compound recipe Rhizoma Corydalis Decumbentis tablet, ZHENGQINGFENGTONGNING, WANTONG JINGU PIAN etc., by pharmacological evaluation and clinical research proof effects such as antiinflammatory, immunomodulating are arranged, but toxic and side effects is also comparatively serious, and common has: gastrointestinal reaction, bone marrow depression, reproductive function infringement, hepatorenal damage, mucocutaneous infringement etc.
Summary of the invention
An object of the present invention is to provide a kind of medicine pill for the treatment of arthromyodynia, it is made by Herba Epimedii, Herba Cistanches, Rhizoma Drynariae, Radix Achyranthis Bidentatae, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Phellodendri, Ramulus Cinnamomi, Flos Carthami.
Wherein, the weight portion proportioning of used Chinese medicine ingredients is: Herba Epimedii 10-30, Herba Cistanches 10-30, Rhizoma Drynariae 10-20, Radix Achyranthis Bidentatae 10-20, Cortex Eucommiae 10-20, Radix Salviae Miltiorrhizae 10-15, Radix Angelicae Sinensis 6-12, Rhizoma Chuanxiong 6-9, Cortex Phellodendri 6-9, Ramulus Cinnamomi 5-9, Flos Carthami 5-15.
Preferably, Herba Epimedii 18, Herba Cistanches 18, Rhizoma Drynariae 15, Radix Achyranthis Bidentatae 12, the Cortex Eucommiae 15, Radix Salviae Miltiorrhizae 10, Radix Angelicae Sinensis 8, Rhizoma Chuanxiong 6, Cortex Phellodendri 6, Ramulus Cinnamomi 6, Flos Carthami 6.
The preparation method of medicine pill of the present invention is: choose Herba Epimedii, Herba Cistanches, Rhizoma Drynariae, Radix Achyranthis Bidentatae, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Phellodendri, the clean medical material of Ramulus Cinnamomi, with conventional high pressure steam sterilization cabinet sterilization, dry, be ground into fine powder, mixing, pill, drying, select ball, pack namely.
Medicine pill of the present invention is exactly to reach in Chinese medicine " kidney governing bones, liver governing tendons " under " prolonged illness must the stasis of blood " theoretical direction, forms in conjunction with the advanced achievement prescription of Chinese medicine modern study.Modern pharmacology studies show that our contained drug Radix Salviae Miltiorrhizae, Rhizoma Drynariae, Herba Epimedii, Rhizoma Chuanxiong can promote the osseous tissue that damages to heal, and promote calcium phosphorus to absorb, and suppress the sclerotin degeneration; Herba Epimedii, Rhizoma Drynariae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, the Cortex Eucommiae all can suppress the arthritic arthroncus of zoopery; Herba Epimedii, Ramulus Cinnamomi, Rhizoma Drynariae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae all can improve the pain threshold after mice causes pain; Herba Epimedii, Radix Angelicae Sinensis, Flos Carthami can improve the mice non-specific immunity; Cortex Phellodendri has antibacterial and anti-inflammation functions; Herba Epimedii, Herba Cistanches, Rhizoma Drynariae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, the Cortex Eucommiae all can suppress the arthritic arthroncus of zoopery.Herba Cistanches has the adrenal gland of activation, discharges 17-hydroxy-11-dehydrocorticosterone, enhance immunity ability and anti-aging effects.
Medicine pill of the present invention can be used for the treatment of Chinese medical discriminations such as neck, waist, the aching and limp pain of lower limb, ankylosis distortion, joint stuffiness, numb limbs and tense tendons, tired weak, aversion to cold and cold limbs, chest distress and belong to deficiency of yang of liver and kidney type arthromyodynia.The hyperosteogeny of modern medicine, cervical spondylosis, ankylosing spondylitis, sciatica, osteoporosis, rheumatoid, rheumatism etc. are seen the person that has the above-mentioned symptom.
Medicine pill of the present invention proves through the clinical practice in 11 years: safety, effective.Can not only alleviate arthralgia, and can protect joint tissue, be conducive to keep for a long time patient's function of joint good and healthy.This prescription drug of present patent application has following characteristics: Chinese medicine preparation does not contain toxicity medical materials such as Radix Aconiti Kusnezoffii, Radix Tripterygii Wilfordii, Semen Strychni, and side effect is little, and life-time service is non-stimulated to gastrointestinal; Start with from invigorating the liver and kidney and two aspects of blood circulation promoting and blood stasis dispelling, improve body constitution, prevent from showing effect repeatedly; Pay attention to protection muscles and bones, prevent bone destruction.Comprehensive function is, improves the joint symptom, improves patient's body constitution, and enhancing body is to the tolerance of wind-cold damp pathogen, fatigue, microbiological attack, prevents that rheumatism from showing effect repeatedly, disables.
The specific embodiment
Embodiment 1
A kind of medicine pill for the treatment of arthromyodynia is pressed Herba Epimedii 10, Herba Cistanches 10, Rhizoma Drynariae 10, Radix Achyranthis Bidentatae 10, the Cortex Eucommiae 10, Radix Salviae Miltiorrhizae 10, Radix Angelicae Sinensis 8, Rhizoma Chuanxiong 6, Cortex Phellodendri 6, Ramulus Cinnamomi 5, the weight proportion of Flos Carthami 5 is chosen clean medical material, with conventional high pressure steam sterilization cabinet sterilization, dry, be ground into fine powder, mixing, pill, drying, select ball, pack and make pill.
Embodiment 2
A kind of medicine pill for the treatment of arthromyodynia is pressed Herba Epimedii 30, Herba Cistanches 30, Rhizoma Drynariae 20, Radix Achyranthis Bidentatae 20, the Cortex Eucommiae 20, Radix Salviae Miltiorrhizae 15, Radix Angelicae Sinensis 12, Rhizoma Chuanxiong 9, Cortex Phellodendri 9, Ramulus Cinnamomi 9, the weight proportion of Flos Carthami 15 is chosen clean medical material, with conventional high pressure steam sterilization cabinet sterilization, dry, be ground into fine powder, mixing, pill, drying, select ball, pack and make pill.
Embodiment 3
A kind of medicine pill for the treatment of arthromyodynia is pressed Herba Epimedii 18, Herba Cistanches 18, Rhizoma Drynariae 15, Radix Achyranthis Bidentatae 12, the Cortex Eucommiae 15, Radix Salviae Miltiorrhizae 12, Radix Angelicae Sinensis 6, Rhizoma Chuanxiong 6, Cortex Phellodendri 6, Ramulus Cinnamomi 6, the weight proportion of Flos Carthami 6 is chosen clean medical material, with conventional high pressure steam sterilization cabinet sterilization, dry, be ground into fine powder, mixing, pill, drying, select ball, pack and make pill.
Clinical data
Over 11 years, medicine pill with the treatment arthromyodynia of above-described embodiment proportioning, treat 11687 routine out-patients, all meet " new Chinese medicine clinical research guideline " the rheumatic Bi syndrome diagnostic criteria of national drug food surveillance authority formulation in 2002 and the diagnostic criteria of " disease of tcm diagnosis criterion of therapeutical effect " rheumatic Bi syndrome that the State Administration of Traditional Chinese Medicines issues nineteen ninety-five.Get rid of following situation, multiple Chinese and western drugs allergic constitution, disease of hematopoietic system, chronic blood loss disease, osteoma are arranged.Male's 4285 examples among the 11687 routine patients, women 7402 examples, the age is in 20-76 year, 46 years old mean age.The course of disease is the longest to be 10 years, and the shortest is 7 days, average 3.3 months.Symptom and sign are seen joint cold type of pain, swelling, light night in daytime weight, coldness of the body with chills, aversion to cold and preference for warmth, hands and feet being not warm, sore waist and aching in the waist and the back, tired weak, lusterless complexion, tastelessness and no thirst or puffiness of the face and limbs, or frequent micturition, joint joint stuffiness, even tetanic deformity.Pale tongue or light dark, tongue is white, thready pulse or heavy thin or heavy string are unable.
Therapeutic Method
Oral medicine pill of the present invention, be 30-90 days the course for the treatment of.Per 10 heavy 1.3 grams.
Instructions of taking: oral, a 3-4g, 3 times on the one.
Criterion of therapeutical effect
Produce effects: symptom all disappears, and lab index is normal substantially;
Effectively: the symptom major part disappears or alleviates, and lab index is clearly better;
Invalid: symptom does not have obvious improvement, the lab index no change.
Therapeutic outcome
Produce effects 7218 examples are 61.8%; Effective 3915 examples, 33.5%; Invalid 554 examples are 4.7%; Total effective rate is 95.3%.
Model case:
Dong Chaowen, the woman, 38 years old, live Huhehaote City's Xincheng District, go to a doctor in August, 2003.Main suit: whole body arthralgia 5 years.History of present illness: the year before, the patient does not have obvious inducement and bilateral metacarpophalangeal joints, bilateral carpal joint pain, slight swelling, morning deadlock, joint stuffiness, elbow, shoulder, knee joint migration pain occur,, hands and feet being not warm tired with the soreness of waist back of the body, aversion to cold and preference for warmth, the pale tongue tongue is white, thready pulse, the RF positive, ESR25mm/h.Impression: rheumatoid.Chinese medical discrimination: arthromyodynia (deficiency of yang of liver and kidney card).
Treatment: treat the medicine pill of arthromyodynia with the present invention, 30 days.
Give with above-mentioned therapy after 30 days symptom be clearly better ESR17mm/h, the RF positive.Continued to take medicine transference cure one month.The state of an illness is steady after the drug withdrawal, follows up a case by regular visits to not recur half a year.
2. Liu's generation honor, the man, 70 years old, live Huhehaote City's Xincheng District, go to a doctor April 1 calendar year 2001.The main suit: right lower limb and pain in the lumbar region pain increased the weight of 7 days 5 years more.History of present illness: before 5 years, bring out outside pain behind waist and the right lower limb after the fatigue.Neck is stranded and sends out deadlock usually, and the two knee joints of companion are unable, hands and feet being not warm, and De Rezeshu, the back state of an illness of suffering from cold before 7 days increases the weight of.The cerebral infarction medical history is previously arranged.X-ray prompting: neck knee joint waist hypertrophy moderate.Have a medical check-up: a little less than the ， Hallux that the is slow in action back of the body is stretched, 3-5 vertebra tenderness, the test of bowing is positive, the stiff tenderness of cervical vertebra, knee joint friction moderate, blood pressure 110/60mmHg, the dark tongue of tongue is white, deep-slow pulse.Impression: general hair style hypertrophy.Chinese medical discrimination: arthromyodynia (deficiency of yang of liver and kidney card).
Treatment: treat the medicine pill of arthromyodynia with the present invention, 90 days.
Give with above-mentioned therapy after 90 days symptom be clearly better, still have discomfort after the waist fatigue, spiritual amelioration.Continued to take medicine transference cure 2 months.The state of an illness is steady after the drug withdrawal, follows up a case by regular visits to not recur half a year.
3. Ma Ersuo, the woman, 60 years old, live holder county, Huhehaote City, go to a doctor May calendar year 2001.The main suit: the gonalgia 1 month, accompany left hemianesthesia.History of present illness: occur the double knee joint cold type of pain after the fatigue, left hemianesthesia is accompanied vexed palpitation and insomnia, lumbago, pain alleviated while getting warmth.The X-ray prompting: knee joint waist hypertrophy is slight.Have a medical check-up: blood pressure 100/70mmHg, positive position, two knee joints are swollen slightly, and the floating patella test positive, knee joint have the friction sense, waist 3-5 tenderness, the test of bowing is positive.Pale tongue with white fur, deep-thready pulse.Impression: knee joint waist hypertrophy.Chinese medical discrimination: arthromyodynia (deficiency of yang of liver and kidney card).Treatment: treat the medicine pill of arthromyodynia with the present invention, 30 days.
Give with above-mentioned therapy after 30 days symptom be clearly better, still have discomfort after the knee joint fatigue, left hemianesthesia alleviates.Continued to take medicine 1 month, symptom all disappears.The state of an illness is steady after the drug withdrawal, follows up a case by regular visits to not recurrence.
4. Liu Yu China, the woman, 59 years old, live Huhehaote City's Saihan District, on July 23rd, 2002 went to a doctor.Main suit: double knee joint pain 10 years.History of present illness: increase the weight of closely over the past half year, the difficulty of having squatted, waist is stranded pain, and cervical vertebra is stiff, soreness of the waist and knees, the foot cold is knotted.The X-ray prompting: cervical vertebra 3-5 hypertrophy moderate, two knee joint patellas and knuckle hypertrophy are slight.Have a medical check-up: walk lamely, do not squat, two knee joint friction senses, the neck waist is stiff, and activity is limited slightly, and the test of bowing is weak positive, and the dark tongue the lung-pulse of tongue is heavy.Impression: the general hair style hyperosteogeny of constitutional.Chinese medical discrimination: arthromyodynia (deficiency of yang of liver and kidney card).
Treatment: the medicine pill 60 days for the treatment of arthromyodynia with the present invention.Give with 60 days stiff pains of posterior joint of above-mentioned therapy symptom and obviously improve, spirit takes a turn for the better, and legs and feet are strong.Continue former side and took medicine 1 month, symptom almost all disappears.Follow up a case by regular visits to after 1 year, the state of an illness is steady, and body constitution is significantly better than former years, and knee joint is sent out deadlock slightly when being Changes in weather.
Claims (2)
1. a medicine pill for the treatment of arthromyodynia is characterized in that being made by the raw material of following weight portion: Herba Epimedii 10-30, Herba Cistanches 10-30, Rhizoma Drynariae 10-20, Radix Achyranthis Bidentatae 10-20, Cortex Eucommiae 10-20, Radix Salviae Miltiorrhizae 10-15, Radix Angelicae Sinensis 6-12, Rhizoma Chuanxiong 6-9, Cortex Phellodendri 6-9, Ramulus Cinnamomi 5-9, Flos Carthami 5-15.
2. according to the medicine pill of claim 1, it is characterized in that the raw material weight proportioning is Herba Epimedii 18, Herba Cistanches 18, Rhizoma Drynariae 15, Radix Achyranthis Bidentatae 12, the Cortex Eucommiae 15, Radix Salviae Miltiorrhizae 10, Radix Angelicae Sinensis 8, Rhizoma Chuanxiong 6, Cortex Phellodendri 6, Ramulus Cinnamomi 6, Flos Carthami 6.
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| CN102824471B (en) * | 2012-08-27 | 2014-03-05 | 王小月 | Traditional Chinese medicine drug for treating spinal disc herniation, sciatica and leg pain |
| CN105194606A (en) * | 2015-09-21 | 2015-12-30 | 成都艾比科生物科技有限公司 | Traditional Chinese medicine composition for treating cold intolerance |
| CN105381397A (en) * | 2015-11-20 | 2016-03-09 | 吴冲 | Traditional Chinese medicine pill for treating waist and leg numbness of women and preparation method thereof |
| CN105582043A (en) * | 2015-12-30 | 2016-05-18 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine composition for treating ankylosing spondylitis |
| CN106955347A (en) * | 2016-01-08 | 2017-07-18 | 陈庆杰 | A kind of Chinese traditional medicine composition formula for treating person in middle and old age's degenerative osteoarthropathy and its application |
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| CN1803187A (en) * | 2005-08-11 | 2006-07-19 | 葛小平 | Chinese herbal medicine for treating lumbar intervertebral disk protrusion and hyperosteogeny |
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Denomination of invention: A Traditional Chinese Medicine Pill for Treating Bi Syndrome Granted publication date: 20130814 Pledgee: Business Department of Inner Mongolia Bank Co.,Ltd. Pledgor: Inner Mongolia Zhong'an Rheumatoid Arthritis Hospital Co.,Ltd. Registration number: Y2024150000042 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20130814 Pledgee: Business Department of Inner Mongolia Bank Co.,Ltd. Pledgor: Inner Mongolia Zhong'an Rheumatoid Arthritis Hospital Co.,Ltd. Registration number: Y2024150000042 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Chinese medicinal pills for treating Bi syndrome Granted publication date: 20130814 Pledgee: Business Department of Inner Mongolia Bank Co.,Ltd. Pledgor: Inner Mongolia Zhong'an Rheumatoid Arthritis Hospital Co.,Ltd. Registration number: Y2025150000011 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |