CN112773826A

CN112773826A - A pharmaceutical composition for caring skin and oral cavity, and its preparation method

Info

Publication number: CN112773826A
Application number: CN202110189124.9A
Authority: CN
Inventors: 宗在军
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-02-19
Filing date: 2021-02-19
Publication date: 2021-05-11

Abstract

The invention discloses a pharmaceutical composition for skin and oral care and a preparation method thereof, wherein the composition comprises the following components: mixture A, mixture B and the rest components; mixture a comprised: fructus Cnidii, radix Sophorae Flavescentis, cortex pseudolaricis, semen Hydnocarpi, nidus Vespae, radix Angelicae Dahuricae, folium Artemisiae Argyi, Ginseng radix, Ganoderma, and ethanol; mixture B comprised: salicylic acid, benzoic acid, borneol and alcohol; the other components comprise: glycerin, peppermint oil, purified water and brilliant blue. The invention also provides a preparation method of the pharmaceutical composition for skin and oral care. The preparation prepared by the pharmaceutical composition for skin and oral care and the preparation method thereof can be used anytime and anywhere, and has the characteristics of reasonable formula, small dosage, obvious effect, no toxic or side effect, quick response, difficult relapse and the like.

Description

A pharmaceutical composition for caring skin and oral cavity, and its preparation method

Technical Field

The invention relates to an external pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for skin and oral care and a preparation method thereof.

Background

Sores, in general, refer to the condition of ulcerated sores on the skin. Such as: hemorrhoids, chilblain, sores, scars and the like, which are troubling many people with orthopedic diseases.

Among them, hemorrhoids are common diseases located in the anus, and can be developed at any age, but the incidence rate is gradually increased with the age. In China, hemorrhoids are the most common anorectal diseases. The hemorrhoids are classified into internal hemorrhoids, external hemorrhoids and mixed hemorrhoids according to the difference of the affected parts.

Common orthopedic diseases include osteomyelitis, bone tuberculosis, hyperosteogeny, rheumatoid arthritis, and the like.

Osteomyelitis is an infection and destruction of bone, and can be caused by aerobic or anaerobic bacteria, mycobacteria, and fungi. Osteomyelitis occurs well in long bones, in the feet of diabetics or in penetrating bone lesions due to trauma or surgery. The most common site in children is the metaphysis of well-supplied long bones, such as the tibia or femur.

Bone tuberculosis is a destructive disease caused by the invasion of tubercle bacillus into bones or joints. The affected part is mostly in bones or joints which are serious in burden, move more and easily produce strain. Preferably, the hair site is the spine, followed by hips, knees, feet, elbows, hands, etc.

Hyperosteogeny is also called as proliferative osteoarthritis, and is a disease with symptoms of joint pain and the like caused by bone joint deformation due to degeneration and degeneration of soft tissues such as cartilage, intervertebral disc, ligament and the like constituting joints. It is common to the middle-aged and the elderly, but postpartum women are also high-incidence people. The types of hyperosteogeny are different due to different parts, and the causes of the diseases are found in clinic and vary from person to person.

Rheumatic arthritis is typically manifested by migratory polyarthritis, usually symmetrical, inflammation and pain in local joints, but no suppuration, inflammation regression, joint function recovery, no deformity of joint stiffness, and skin with annular erythema and subcutaneous nodules.

Disclosure of Invention

The invention aims to provide an external pharmaceutical composition and a preparation method thereof, which can solve the existing problems, can be used anytime and anywhere, and can conveniently and rapidly prevent and treat skin diseases and oral diseases in a targeted manner.

In order to achieve the above objects, the present invention provides a pharmaceutical composition for skin and oral care, wherein the composition comprises: mixture A, mixture B and the rest components; mixture a comprised: fructus Cnidii, radix Sophorae Flavescentis, cortex pseudolaricis, semen Hydnocarpi, nidus Vespae, radix Angelicae Dahuricae, folium Artemisiae Argyi, Ginseng radix, Ganoderma, and ethanol; mixture B comprised: salicylic acid, benzoic acid, borneol and alcohol; the other components comprise: glycerin, peppermint oil, purified water and brilliant blue.

The pharmaceutical composition for skin and oral care, wherein the mixture a comprises, by weight: 8-12 parts of fructus cnidii, 8-12 parts of radix sophorae flavescentis, 8-12 parts of cortex pseudolaricis, 8-12 parts of chaulmoogra, 8-12 parts of honeycomb, 8-12 parts of radix angelicae, 8-12 parts of folium artemisiae argyi, 18-22 parts of ginseng, 18-22 parts of lucid ganoderma and 950-1050 parts of alcohol.

The pharmaceutical composition for skin and oral care, wherein the mixture a comprises, by weight: 10 parts of common cnidium fruit, 10 parts of lightyellow sophora root, 10 parts of pseudolarix, 10 parts of chaulmoogra seed, 10 parts of honeycomb, 10 parts of dahurian angelica root, 10 parts of argy wormwood leaf, 20 parts of ginseng, 20 parts of lucid ganoderma and 1000 parts of alcohol.

The pharmaceutical composition for skin and oral care, wherein the mixture B comprises, in parts by weight: 28-32 parts of salicylic acid, 28-32 parts of benzoic acid, 0.5-1.5 parts of borneol and 450-550 parts of alcohol.

The pharmaceutical composition for skin and oral care, wherein the mixture B comprises, in parts by weight: 30 parts of salicylic acid, 30 parts of benzoic acid, 1 part of borneol and 500 parts of alcohol.

The pharmaceutical composition for skin and oral care, wherein the rest components comprise the following components in parts by weight: 28-32 parts of glycerin, 3-8 parts of peppermint oil, 1400-1600 parts of purified water and 0.05-0.15 part of brilliant blue.

The pharmaceutical composition for skin and oral care, wherein the rest components comprise the following components in parts by weight: 30 parts of glycerol, 5 parts of peppermint oil, 1500 parts of purified water and 0.1 part of brilliant blue.

The present invention also provides a method for preparing the above pharmaceutical composition for skin and oral care, wherein the method comprises: step 1, weighing raw materials in proportion; step 2, respectively drying fructus cnidii, radix sophorae flavescentis, cortex pseudolaricis, chaulmoogratree seed, honeycomb, radix angelicae, folium artemisiae argyi, ginseng, lucid ganoderma and borneol, and then grinding and crushing; step 3, putting fructus cnidii, radix sophorae flavescentis, cortex pseudolaricis, chaulmoogratree seed, honeycomb, radix angelicae, folium artemisiae argyi, ginseng and lucid ganoderma into alcohol to prepare a mixture A for two months; step 4, dissolving borneol, salicylic acid and benzoic acid in alcohol and uniformly stirring to obtain a mixture B; and 5, uniformly mixing the mixture A and the mixture B, adding glycerol and peppermint oil, uniformly stirring, standing for 6 days, sequentially adding purified water and brilliant blue, standing for one week, filtering and bottling.

The preparation method of the pharmaceutical composition for skin and oral care is characterized in that the particle size of the ground particles is 30-40 meshes.

The preparation method of the pharmaceutical composition for skin and oral care is used for preparing an external preparation.

The pharmaceutical composition for skin and oral care and the preparation method thereof provided by the invention have the following advantages:

the pharmaceutical composition for skin and oral care provided by the invention has the effects of relieving pain, diminishing inflammation, removing necrotic tissue and promoting granulation, can automatically remove small dead bones or foreign bodies and the like, and has the characteristics of short administration time, quick response, economy, simplicity, convenience, good curative effect and the like.

The preparation can be used for treating skin swelling and ulcer, external sores, hemorrhoids, chronic osteomyelitis, bone tuberculosis, hyperosteogeny, rheumatoid arthritis, diabetes, hand and foot necrosis and the like; has the characteristics of reasonable formula, small dosage, obvious effect, no toxic or side effect, low recurrence rate and the like.

Detailed Description

The following further describes embodiments of the present invention.

The present invention provides a pharmaceutical composition for skin and oral care comprising: mixture A, mixture B and the rest components; mixture a comprised: fructus Cnidii, radix Sophorae Flavescentis, cortex pseudolaricis, semen Hydnocarpi, nidus Vespae, radix Angelicae Dahuricae, folium Artemisiae Argyi, Ginseng radix, Ganoderma, and ethanol; mixture B comprised: salicylic acid, benzoic acid, borneol and alcohol; the other components comprise: glycerin, peppermint oil, purified water and brilliant blue. The raw materials of the medicines respectively accord with the corresponding national standards.

Wherein fructus Cnidii is named as wild carrot seed, and is dried mature fruit of cnidium monnieri (L.) DC of Umbelliferae. Pungent and bitter with warm nature. It enters kidney meridian. Has effects of eliminating dampness, dispelling pathogenic wind, killing parasites, relieving itching, warming kidney and tonifying yang. Can be used for treating pudendal pruritus, leukorrhagia, eczema, pruritus, lumbago due to damp arthralgia, sexual impotence due to kidney deficiency, and infertility due to cold womb.

Radix Sophorae Flavescentis is dried root of radix Sophorae Flavescentis of Leguminosae. Bitter taste and cold nature. It enters heart, liver, stomach, large intestine and bladder meridians. Has the effects of clearing heat, eliminating dampness, killing parasites and promoting urination. Can be used for treating hemorrhoid dysentery with fever, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pruritus vulvae, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonal vaginitis.

The cortex pseudolaricis is root bark or stem bark near root of herba Lysimachiae Christinae. Pungent and bitter with warm nature. Enter spleen meridian. Has the effects of dispelling pathogenic wind, removing dampness, killing parasites and relieving itching. It can be used for treating scabies, eczema, and neurodermatitis.

The semen Hydnocarpi is mature seed of Hydnocarpus davidii and Hydnocarpus davidii of Hydnocarpus. Pungent flavor and warm property. It enters liver and spleen meridians. Has the effects of dispelling pathogenic wind, removing dampness, counteracting toxic substances and killing parasites. It is commonly used for leprosy, syphilis, scabies, wine Zha nose and acne.

The nidus Vespae is the nest of Vespidae insect Vespa mandala, Japanese hornet or heterodorous wasp. The wild plants are all wild in China and more in south China. Collected in the whole year, but collected in autumn and winter. Sun drying or steaming, removing dead pupa of dead bee, sun drying, cutting into pieces, and parching. Also known as nidus Vespae. Sweet in nature and taste and mild in nature. It enters stomach meridian. Has the effects of counteracting toxic substances, killing parasite, dispelling pathogenic wind and relieving pain. Can be used for treating pyocutaneous disease, toxic swelling, acute mastitis, scrofula, intractable tinea, pruritus, cancer, rheumatalgia, toothache, and rubella pruritus; it is also indicated for impotence, pharyngitis, ascariasis and taeniasis. Proper amount of the powder is externally used, and the powder is mixed with oil and applied or decocted with water for mouth rinsing or the affected part is fumigated and washed.

The angelica dahurica is a perennial tall herb plant, contains rich protein fat, carbohydrate and trace elements, has high medicinal value, can expel wind and dissipate dampness, expel pus, promote tissue regeneration and relieve pain when used as a medicament, and mainly treats diseases such as wind-cold type common cold, forehead headache, nasosinusitis, toothache, anal fistula, hematochezia, leucorrhea, carbuncle-abscess pyogenic infections, burn and the like.

The folium Artemisiae Argyi is leaf of Artemisia argyi of Compositae. Cultivating for 9 months and 2 nd month, cutting off aerial parts, picking off tender tips of leaves, and sun drying. Pungent and bitter taste, warm nature; it enters liver, spleen and kidney meridians. Has effects of warming channels, stopping bleeding, dispelling cold, relieving pain, eliminating dampness, and relieving itching. It can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, gestational hemorrhage, menoxenia, dysmenorrhea, threatened abortion, psychroalgia of heart and abdomen, diarrhea, dysentery, cholera, spasm of muscle, leukorrhagia, eczema, scabies, tinea, hemorrhoid, and carbuncle.

Ginseng is a perennial herb and contains various saponin and polysaccharide components. The succulent root of ginseng is a well-known tonic, is suitable for regulating blood pressure, recovering heart function, neurasthenia and asthenia, and also has expectorant, stomach invigorating, diuretic and exciting effects. Sweet and slightly bitter in taste, warm and mild in nature. It enters spleen, lung and heart meridians. Has effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, tranquilizing, and improving intelligence. Mainly treats asthenia, desire for desertion, cold limbs and a little pulse, spleen deficiency, poor appetite, lung deficiency, cough and asthma, body fluid deficiency, thirst, internal heat, diabetes, deficiency of deficiency caused by chronic diseases, palpitation, insomnia, impotence and cold womb; heart failure, cardiogenic shock.

Ganoderma is dry fruiting body of Ganoderma lucidum or Ganoderma sinensis of Polyporaceae. Sweet in taste and neutral in nature; it enters heart, lung, liver and kidney meridians. Has effects in invigorating qi, tranquilizing mind, relieving cough and asthma, and prolonging life, and can be used for treating vertigo, insomnia, palpitation, short breath, neurasthenia, asthenia, cough and asthma, and resisting tumor and oxidation. It can be used for treating restlessness of heart-mind, insomnia, palpitation due to fright, cough, asthma, excessive phlegm, and asthenia.

Borneolum, named as Borneolum Syntheticum, pericarpium Citri Tangerinae, folium Artemisiae Argyi, Borneolum Syntheticum, Serissa serissoides, Borneolum Syntheticum, bornyl alcohol, and Borneolum Syntheticum, and is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of Cinnamomum camphora of Lauraceae by steam distillation and recrystallization. Colorless, transparent or semitransparent flaky crisp crystals with faint scent, pungent taste and cool taste; it is volatile, and can be ignited to produce thick smoke and flame with light. It enters heart, spleen and lung meridians. The product has effects of inducing resuscitation, refreshing mind, clearing heat, removing toxic substances, improving eyesight, and removing nebula, and can be used for treating hemorrhoid, fever, hyperpyrexia, coma, apoplexy, phlegm syncope, convulsion, summer-heat dampness covering resuscitation, pharyngitis, deafness, aphtha, swelling of teeth, skin ulcer, carbuncle, malnutritional hemorrhoid, conjunctival congestion, swelling and pain, nebula, and eye covering.

Salicylic acid is a fat-soluble organic acid and is a white crystalline powder in appearance. It is an important fine chemical raw material existing in willow bark, folium Callicarpae Formosanae and Betula platyphylla in nature, and can be used for preparing medicine such as aspirin.

Benzoic acid is an organic compound of the aromatic acids, and is also the simplest aromatic acid. Benzoic acid is widely found in nature in the form of the free acid, ester or derivative thereof. The method is mainly used for preparing the sodium benzoate preservative and synthesizing medicaments and dyes; it is also used for preparing plasticizer, mordant, bactericide, perfume, etc.

Glycerol, i.e., glycerol, is colorless, odorless, sweet in flavor, clear, viscous, and liquid in appearance, and is an organic substance. Can absorb moisture from the air and also can absorb hydrogen sulfide, hydrogen cyanide and sulfur dioxide. Insoluble in benzene, chloroform, carbon tetrachloride, carbon disulfide, petroleum ether and oils. The glycerin has the functions of moisturizing, moistening, high activity, antioxidation, alcoholization promotion and the like. Each gram of glycerol can generate 4 kcal of heat after being completely oxidized, and the blood sugar and the insulin level cannot be changed after being absorbed by a human body. Glycerin is a commonly used sweetener and humectant in the food processing industry, most commonly found in sports foods and milk substitutes.

The peppermint oil is peppermint extract, and has special cool fragrance, pungent taste and cool aftertaste. The product is light grass green liquid or light yellow clear liquid, and can be solidified into solid when being cooled slightly, and has strong peppermint fragrance and cool slight bitter taste. The color of the tea is gradually deepened after the tea is stored for a long time. The product can be mixed with ethanol, chloroform or ethanol. It is used for expelling mosquito and relieving fatigue.

Preferably, mixture a comprises, in parts by weight: 8-12 parts of fructus cnidii, 8-12 parts of radix sophorae flavescentis, 8-12 parts of cortex pseudolaricis, 8-12 parts of chaulmoogra, 8-12 parts of honeycomb, 8-12 parts of radix angelicae, 8-12 parts of folium artemisiae argyi, 18-22 parts of ginseng, 18-22 parts of lucid ganoderma and 950-1050 parts of alcohol.

More preferably, mixture a comprises, in parts by weight: 10 parts of common cnidium fruit, 10 parts of lightyellow sophora root, 10 parts of pseudolarix, 10 parts of chaulmoogra seed, 10 parts of honeycomb, 10 parts of dahurian angelica root, 10 parts of argy wormwood leaf, 20 parts of ginseng, 20 parts of lucid ganoderma and 1000 parts of alcohol.

Preferably, mixture B comprises, in parts by weight: 28-32 parts of salicylic acid, 28-32 parts of benzoic acid, 0.5-1.5 parts of borneol and 450-550 parts of alcohol.

More preferably, mixture B comprises, in parts by weight: 30 parts of salicylic acid, 30 parts of benzoic acid, 1 part of borneol and 500 parts of alcohol.

Preferably, the rest components comprise, in parts by weight: 28-32 parts of glycerin, 3-8 parts of peppermint oil, 1400-1600 parts of purified water and 0.05-0.15 part of brilliant blue.

More preferably, the remaining components comprise, in parts by weight: 30 parts of glycerol, 5 parts of peppermint oil, 1500 parts of purified water and 0.1 part of brilliant blue.

The present invention also provides a process for the preparation of the pharmaceutical composition for skin and oral care, which process comprises: step 1, weighing raw materials in proportion; step 2, respectively drying fructus cnidii, radix sophorae flavescentis, cortex pseudolaricis, chaulmoogratree seed, honeycomb, radix angelicae, folium artemisiae argyi, ginseng, lucid ganoderma and borneol, and then grinding and crushing; step 3, putting fructus cnidii, radix sophorae flavescentis, cortex pseudolaricis, chaulmoogratree seed, honeycomb, radix angelicae, folium artemisiae argyi, ginseng and lucid ganoderma into alcohol to prepare a mixture A for two months; step 4, dissolving borneol, salicylic acid and benzoic acid in alcohol and uniformly stirring to obtain a mixture B; and 5, uniformly mixing the mixture A and the mixture B, adding glycerol and peppermint oil, uniformly stirring, standing for 6 days, sequentially adding purified water and brilliant blue, standing for one week, filtering and bottling.

Preferably, the particle size of the grinding and crushing is in a range of 30-40 meshes.

The pharmaceutical composition is used for the preparation of a topical formulation, preferably as a liquid spray.

The pharmaceutical compositions for skin and oral care and the methods for preparing the same provided by the present invention are further described below with reference to the examples.

Example 1

A pharmaceutical composition for skin and oral care, the composition comprising: mixture A, mixture B and the rest components; mixture a comprised: fructus Cnidii, radix Sophorae Flavescentis, cortex pseudolaricis, semen Hydnocarpi, nidus Vespae, radix Angelicae Dahuricae, folium Artemisiae Argyi, Ginseng radix, Ganoderma, and ethanol; mixture B comprised: salicylic acid, benzoic acid, borneol and alcohol; the other components comprise: glycerin, peppermint oil, purified water and brilliant blue. The raw materials of the medicines respectively accord with the corresponding national standards.

Preferably, mixture a comprises, in parts by weight: 10 parts of common cnidium fruit, 10 parts of lightyellow sophora root, 10 parts of pseudolarix, 10 parts of chaulmoogra seed, 10 parts of honeycomb, 10 parts of dahurian angelica root, 10 parts of argy wormwood leaf, 20 parts of ginseng, 20 parts of lucid ganoderma and 1000 parts of alcohol.

More preferably, mixture a comprises: 10g of fructus cnidii, 10g of radix sophorae flavescentis, 10g of cortex pseudolaricis, 10g of chaulmoogratree seed, 10g of honeycomb, 10g of radix angelicae, 10g of folium artemisiae argyi, 20g of ginseng, 20g of lucid ganoderma and 1000g of alcohol.

Preferably, mixture B comprises, in parts by weight: 30 parts of salicylic acid, 30 parts of benzoic acid, 1 part of borneol and 500 parts of alcohol.

More preferably, mixture B comprises, in parts by weight: 30g of salicylic acid, 30g of benzoic acid, 1g of borneol and 500g of alcohol.

Preferably, the rest components comprise, in parts by weight: 30 parts of glycerol, 5 parts of peppermint oil, 1500 parts of purified water and 0.1 part of brilliant blue.

More preferably, the remaining components comprise, in parts by weight: 30ml of glycerol, 5ml of peppermint oil, 1500g of purified water and 0.1g of brilliant blue.

The present embodiments also provide a method for preparing the pharmaceutical composition for skin and oral care, the method comprising: step 1, weighing the raw materials in proportion.

Step 2, respectively drying fructus cnidii, radix sophorae flavescentis, cortex pseudolaricis, chaulmoogratree seed, honeycomb, radix angelicae, folium artemisiae argyi, ginseng, lucid ganoderma and borneol, and then grinding and crushing. The particle size range of grinding and crushing is 30-40 meshes.

And step 3, putting the common cnidium fruit, the lightyellow sophora root, the pseudolarix, the chaulmoogra seed, the honeycomb, the angelica dahurica, the folium artemisiae argyi, the ginseng and the lucid ganoderma into alcohol to be processed for two months to obtain a mixture A.

And 4, dissolving borneol, salicylic acid and benzoic acid in alcohol and uniformly stirring to obtain a mixture B.

And 5, uniformly mixing the mixture A and the mixture B, adding glycerol and peppermint oil, uniformly stirring, standing for 6 days, sequentially adding purified water and brilliant blue, standing for one week, filtering and bottling.

Example 2

Preferably, mixture a comprises, in parts by weight: 8 parts of fructus cnidii, 8 parts of radix sophorae flavescentis, 8 parts of cortex pseudolaricis, 8 parts of chaulmoogratree seed, 8 parts of honeycomb, 8 parts of radix angelicae, 8 parts of folium artemisiae argyi, 18 parts of ginseng, 18 parts of ganoderma lucidum and 950 parts of alcohol.

More preferably, mixture a comprises: 8g of fructus cnidii, 8g of radix sophorae flavescentis, 8g of cortex pseudolaricis, 8g of chaulmoogratree seed, 8g of honeycomb, 8g of radix angelicae, 8g of folium artemisiae argyi, 18g of ginseng, 18g of ganoderma lucidum and 950g of alcohol.

Preferably, mixture B comprises, in parts by weight: 28 parts of salicylic acid, 28 parts of benzoic acid, 0.5 part of borneol and 450 parts of alcohol.

More preferably, mixture B comprises, in parts by weight: salicylic acid 28g, benzoic acid 28g, borneol 0.5g and alcohol 450 g.

Preferably, the rest components comprise, in parts by weight: 28 parts of glycerin, 3 parts of peppermint oil, 1400 parts of purified water and 0.05 part of brilliant blue.

More preferably, the remaining components comprise, in parts by weight: 28ml of glycerin, 3ml of peppermint oil, 1400g of purified water and 0.05g of brilliant blue.

Example 3

Preferably, mixture a comprises, in parts by weight: 12 parts of common cnidium fruit, 12 parts of lightyellow sophora root, 12 parts of pseudolarix, 12 parts of chaulmoogra, 12 parts of honeycomb, 12 parts of dahurian angelica root, 12 parts of argy wormwood leaf, 22 parts of ginseng, 22 parts of lucid ganoderma and 1050 parts of alcohol.

More preferably, mixture a comprises: 12g of fructus cnidii, 12g of radix sophorae flavescentis, 12g of cortex pseudolaricis, 12g of chaulmoogratree seed, 12g of honeycomb, 12g of radix angelicae, 12g of folium artemisiae argyi, 22g of ginseng, 22g of lucid ganoderma and 1050g of alcohol.

Preferably, mixture B comprises, in parts by weight: 32 parts of salicylic acid, 32 parts of benzoic acid, 1.5 parts of borneol and 550 parts of alcohol.

More preferably, mixture B comprises, in parts by weight: 32g of salicylic acid, 32g of benzoic acid, 1.5g of borneol and 550g of alcohol.

Preferably, the rest components comprise, in parts by weight: 32 parts of glycerin, 8 parts of peppermint oil, 1600 parts of purified water and 0.15 part of brilliant blue.

More preferably, the remaining components comprise, in parts by weight: 32ml of glycerin, 8ml of peppermint oil, 1600g of purified water and 0.15g of brilliant blue.

The patients were selected by a random method and divided into experimental groups and control groups, each group containing 180 patients. Experimental groups the composition prepared in example 1 of the present invention was applied to spray-wipe the skin or to gargle the mouth, and the dosage was adjusted according to the area of the affected part. After all patients in the available experimental groups were observed to take effect on the same day, 97.2% of symptoms were cured after 3 days, and basically no recurrence was observed.

The invention provides a pharmaceutical composition for skin and oral care and a preparation method thereof, more than ten traditional Chinese medicines are selected, infused and extracted, and synthesized into liquid for spraying. The composition provided by the invention is based on the differentiation of symptoms and signs of traditional Chinese medicine, aims at the etiology and pathogenesis of diseases and utilizes the compatibility principle that medicines supplement each other, purposefully combines the medicines according to the organization structure of monarch, minister, assistant and guide, enables the medicines in the formula and the compatibility thereof to be screwed with the pathogenesis of the diseases, and enables the comprehensive effect after the medicines are combined to be highly unified with the established treatment method.

While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.

Claims

1. A pharmaceutical composition for skin and oral care, comprising: mixture A, mixture B and the rest components;

mixture a comprised: fructus Cnidii, radix Sophorae Flavescentis, cortex pseudolaricis, semen Hydnocarpi, nidus Vespae, radix Angelicae Dahuricae, folium Artemisiae Argyi, Ginseng radix, Ganoderma, and ethanol;

mixture B comprised: salicylic acid, benzoic acid, borneol and alcohol;

the other components comprise: glycerin, peppermint oil, purified water and brilliant blue.

2. The pharmaceutical composition for skin and oral care according to claim 1, wherein said mixture a comprises, in parts by weight: 8-12 parts of fructus cnidii, 8-12 parts of radix sophorae flavescentis, 8-12 parts of cortex pseudolaricis, 8-12 parts of chaulmoogra, 8-12 parts of honeycomb, 8-12 parts of radix angelicae, 8-12 parts of folium artemisiae argyi, 18-22 parts of ginseng, 18-22 parts of lucid ganoderma and 950-1050 parts of alcohol.

3. The pharmaceutical composition for skin and oral care according to claim 2, wherein said mixture a comprises, in parts by weight: 10 parts of common cnidium fruit, 10 parts of lightyellow sophora root, 10 parts of pseudolarix, 10 parts of chaulmoogra seed, 10 parts of honeycomb, 10 parts of dahurian angelica root, 10 parts of argy wormwood leaf, 20 parts of ginseng, 20 parts of lucid ganoderma and 1000 parts of alcohol.

4. The pharmaceutical composition for skin and oral care according to claim 1, wherein said mixture B comprises, in parts by weight: 28-32 parts of salicylic acid, 28-32 parts of benzoic acid, 0.5-1.5 parts of borneol and 450-550 parts of alcohol.

5. The pharmaceutical composition for skin and oral care according to claim 4, wherein said mixture B comprises, in parts by weight: 30 parts of salicylic acid, 30 parts of benzoic acid, 1 part of borneol and 500 parts of alcohol.

6. The pharmaceutical composition for skin and oral care of claim 1, wherein said remaining ingredients comprise, in parts by weight: 28-32 parts of glycerin, 3-8 parts of peppermint oil, 1400-1600 parts of purified water and 0.05-0.15 part of brilliant blue.

7. The pharmaceutical composition for skin and oral care of claim 6, wherein said remaining ingredients comprise, in parts by weight: 30 parts of glycerol, 5 parts of peppermint oil, 1500 parts of purified water and 0.1 part of brilliant blue.

8. A process for the preparation of a pharmaceutical composition according to any one of claims 1 to 7 for skin and oral care, said process comprising:

step 1, weighing raw materials in proportion;

step 2, respectively drying fructus cnidii, radix sophorae flavescentis, cortex pseudolaricis, chaulmoogratree seed, honeycomb, radix angelicae, folium artemisiae argyi, ginseng, lucid ganoderma and borneol, and then grinding and crushing;

step 3, putting fructus cnidii, radix sophorae flavescentis, cortex pseudolaricis, chaulmoogratree seed, honeycomb, radix angelicae, folium artemisiae argyi, ginseng and lucid ganoderma into alcohol to prepare a mixture A for two months;

step 4, dissolving borneol, salicylic acid and benzoic acid in alcohol and uniformly stirring to obtain a mixture B;

9. The method of preparing a pharmaceutical composition for skin and oral care according to claim 8, wherein said grind size ranges from 30 to 40 mesh.

10. The method of preparing a pharmaceutical composition for skin and oral care of claim 8, wherein said pharmaceutical composition is used to prepare an external preparation.