CN100584368C - Medicine for treating rheumatoid and rheumatoid arthritis and its preparation method - Google Patents

Abstract

The invention discloses a medicament for treating rheumatic arthritis and rheumatoid arthritis, which mainly comprises long-nosed pit viper, gastrodia tuber, Ligusticum wallichii, Chinese angelica root, olive root, Tuyamu, white spirit, water and compound levisticum and indomethacin capsule by a predetermined weight proportions. The composition can be prepared into any of the conventional oral administration preparation by employing the conventional methods for preparing traditional Chinese medicinal preparation.

Description

A kind of medicine for the treatment of rheumatic, rheumatoid arthritis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of rheumatic arthritis, rheumatoid arthritis and preparation method thereof.

Background technology

One of symptom of rheumatic arthritis, rheumatoid arthritis is temporary transient and chronic arthrodynia of extremities, the numbness that breaks out; Two of symptom is random whenever wind and rain, and the trick joint all can pain, edema; Three of symptom is that trick joint pain is unable, severe patient meeting apoplexy and hemiplegia; Four of symptom is limitation outbreaks, and local joint symmetry or asymmetric morbidity pain are unbearably.Treat treating rheumatic arthritis medicines such as taking expel wind to dredge collateral often and control its outbreak, but these curative effect of medication still can not be satisfactory.

Summary of the invention:

The purpose of this invention is to provide a kind of more effectively, and the medicine of rheumatic arthritis, rheumatoid arthritis is treated in the smelting that can remove old complaint.

Another object of the present invention has provided the preparation method of this medicine.

Medicine of the present invention is based on secret prescription handed down in the family from generation to generation, selected Agkistrodon, Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Canarii albi root, native duck mother, Chinese liquor, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Fructus Chaenomelis, Radix Achyranthis Bidentatae, indomethacin, piroxicam, the female meat of native duck, water make up, wherein Agkistrodon property sweet, become, wet, poisonous, the function of expel wind to dredge collateral, dispelling the wind and dampness pathogens insensitive impediment, apoplexy and hemiplegia is arranged; Can also relieving spasm by subduing liver-wind, control infantile convulsion, tetanus, wind syndrome of head pain and control the function of poliomyelitis convalescent period, hepatocarcinoma; Wherein the flat sweet in the mouth of Rhizoma Gastrodiae has the function that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. and calm the frightened, and cures mainly the diseases such as spasm, infantile convulsion of having a dizzy spell, twitch.Warm in nature, the acrid in the mouth of Rhizoma Chuanxiong, the function blood-activating and qi-promoting cures mainly the dispelling wind and removing obstruction in the collateral pain relieving, controls headache, rheumatic arthralgia, treating swelling and pain by traumatic injury.Radix Angelicae Sinensis sweet in the mouth suffering warm in nature, function is enriched blood, the promoting blood flow to regulate menstruation pain relieving, controls angina pectoris, thromboangiitis obliterans.Fructus Canarii albi root sweet in the mouth warm in nature, major function clearing heat for detumescence relieving pain and activating blood circulation.The female meat of soil duck sweet in the mouth warm in nature has the empty collateral dredging of enriching blood, activating blood and removing stasis function.Rhizoma Et Radix Notopterygii bitter in the mouth suffering warm in nature.Have the cold expelling of inducing sweat, removing dampness to relieve pain is controlled the function of arthralgia due to wind-cold dampness, wind syndrome of head pain, the sick stiffness of the nape of ridge.Radix Angelicae Pubescentis slightly warm in nature bitter in the mouth suffering has expelling wind and dampness, pain relieving, dispelling the wind and dampness pathogens arthralgia pain, waist knee joint acid disease, YIN-cold headache, facial paralysis mouth

, the cold expelling that induces sweat is controlled the painful function of a general pain.Fructus Chaenomelis sour in the mouth warm in nature has the function of relaxing muscles and tendons and activating QI and blood in the collateral, the contracture of dispelling the wind and dampness pathogens arthromyodynia muscle arteries and veins, beriberi rheumatism multiple abscess.The flat bitter in the mouth of Radix Achyranthis Bidentatae, sweet, sour has activating blood and removing stasis, controls all diseases of blood stasis, and sharp joint, strong waist knee joint are controlled the function of arthromyodynia, flaccidity.Make each efficacy of drugs produce synergism the said medicine combination, thereby can effectively treat the recurrence of rheumatic arthritis, rheumatoid arthritis, and reach the effect of radical cure.Medicine of the present invention can contain medicament A, B, C, and medicament A, B, C can distinguish use separately, also can share, but to share to good.

Medicament A component by the preparation of following weight portion scope, all have curative effect preferably:

55～90 parts of Agkistrodons, 90～150 parts in Rhizoma Gastrodiae, 100～120 parts of Rhizoma Chuanxiongs, 100～120 parts of Radix Angelicae Sinensis, 1500～2000 parts of the Chinese liquor of 60 degree

The preparation method of medicament A of the present invention is, by above-mentioned weight portion proportioning, gets the preparation in advance of Agkistrodon, Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, and it comprises the following steps:

A. Agkistrodon meat is dried;

B. the Rhizoma Gastrodiae section is dried;

C. Rhizoma Chuanxiong, Chinese angelica slicing are dried;

D. the medicament mixed with drying in the sun Agkistrodon meat and Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Angelicae Sinensis is developed into powder;

E. the medicated powder of pulverizing was immersed in 60 degree Chinese liquor 20～40 days, preferred version is 30 days;

F, method of Chinese medicinal are routinely made the oral type of medicament A or are become pill, powder and tablet.

Preferred version is: get 90 parts of Agkistrodons, 150 parts in Rhizoma Gastrodiae, 120 parts of Rhizoma Chuanxiongs, 120 parts of Radix Angelicae Sinensis, be dipped in 1600 parts of the Chinese liquor 1 month of 60 degree, make medicament A.

The component of medicament B all has curative effect preferably by following weight portion scope preparation:

150～200 parts of Fructus Canarii albi roots, 250～300 parts of the female meat of native duck, 1000～1500 parts in water.

Preferred version is: get 160 parts of Fructus Canarii albi roots, 280 parts of the female meat of native duck, 1200 parts in water.

The preparation method of medicament B of the present invention is, gets Fructus Canarii albi root, native duck mother, water by above-mentioned weight portion and concocts in advance, and it comprises the following steps:

A. Fructus Canarii albi undercut sheet is dried;

B. with the female meat section of native duck;

C. Fructus Canarii albi root, native duck mother, water are mixed, slow fire steamed 45～70 minutes; Preferred version is 1 hour;

D, method of Chinese medicinal are routinely made liquid agent, pill, powder, tablet, capsule etc.

The component that medicament C--compound recipe Radix Angelicae Pubescentis indometacin capsules is every is in the following weight parts scope, all has curative effect preferably:

50～55 parts of Radix Angelicae Pubescentiss, 50～55 parts of Rhizoma Et Radix Notopterygiis, 50～55 parts of Fructus Chaenomeliss, 50～55 parts of Radix Achyranthis Bidentataes, 25～30 parts of indomethacins, 10～20 parts of piroxicams.

The component preferred version that compound recipe Radix Angelicae Pubescentis indometacin capsules is every is: Radix Angelicae Pubescentis 50mg, Rhizoma Et Radix Notopterygii 50mg, Fructus Chaenomelis 50mg, Radix Achyranthis Bidentatae 50mg, indomethacin 25mg, piroxicam 10mg.

The preparation method of the medicine of medicament C--compound recipe Radix Angelicae Pubescentis indometacin capsules is:

Get Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Fructus Chaenomelis, Radix Achyranthis Bidentatae, indomethacin, piroxicam,, mix being developed into powder, the medicated powder of pulverizing is sieved by above-mentioned weight portion proportioning; Then, method of Chinese medicinal is routinely made capsule ball or liquid preparation, powder, tablet etc.

Advantage of the present invention is that technology is simple, production and processing convenient, economical and practical, easily buying of medicine, low price, evident in efficacy.

The specific embodiment

Below further sketch the beneficial effect of medicine of the present invention by testing example, and give an example furtherly

Bright the present invention, (but not being limitation of the present invention).

Test example 1: drug toxicity animal experiment data:

Test material: get medicine of the present invention (to call rheumatism treating medicine powder in the following text).Test method: select 20 of rabbit, the male and female dual-purpose, body weight 2.0-2.9 kilogram is in harmonious proportion rheumatism treating medicine powder with eliminating cold for resuscitation water, and dosage is 2.06 kilograms, adopts the administration by gavage administration, and every day, secondary serve on 150 days, and every day, the observer exempted from situation.The result shows that after the rabbit perfusion, movable food is all normal, and medicine has no side effect.

Test example 2: data is put to the proof in clinical observation:

1, accept patient's totally 300 examples for medical treatment, male's 200 examples wherein, women's 100 examples, men and women's ratio is 2: 1, age 6-10 year 5 examples, 20-30 year 50 examples, 31 years old-40 years old 55 examples, 190 examples more than 40 years old.Wherein light-duty phases 30 example, medium-sized 250 examples, heavy 20 examples.

2, diagnostic criteria:

Rheumatic arthritis, rheumatoid arthritis are a kind of chronic rheumatoid joint property diseases, clinically are divided into three types:

1. the light-duty phase: petit mal, sick type is lighter, and their early stage unexpected joint trick was ached 2-3 days, and no lump is existing

2. the medium-sized phase: random whenever wind rains and will shift to an earlier date outbreak in 2-3 days, and lump, pain appear in locality trick arthralgia, even numb 2-3 days of trick meeting, and the fiber crops pain is felt in trick, inconvenience, does not have power.

3. the heavy phase: grand mal, there is not random wind to rain no matter have, patient understands the whole body joint and tingles unbearably, and trick is swollen and ache even modification, and motion is inconvenient, and whole body is uncomfortable, and patient can't take care of oneself.

3, Therapeutic Method

Oral 2 times of every day, early, after the supper each 1 time, 30 is a course of treatment, removes old complaint 3 courses of treatment.

4, efficacy assessment standard

Produce effects: behind drug treatment, health takes a turn for the better, and the intermission prolongs, and observing in two and half does not have the recidivist.

Take a turn for the better: physical condition takes a turn for the better, and the intermission prolongs relatively.

Invalid: as not reach improvement standard person.

5, efficacy result

Through three course of therapy, among the 300 routine patients, wherein light-duty phases 50 people, medium-sized phases 140 people, heavy 100 people's produce effects; The produce effects rate 96.7% that heals, medium-sized phases 4 people, heavy phase 1 people takes a turn for the better, and improvement rate 1.7%, total effective rate are 98.4.

Embodiment 1

Each component of medicament A, B, C is pressed column weight amount proportioning in the described medicine:

Agkistrodon 55-90g Fructus Canarii albi root 150-200g

The female meat 250-300g of Rhizoma Gastrodiae 90-150g soil duck

Rhizoma Chuanxiong 100-120g water 1000-1500g

Radix Angelicae Sinensis 100-120g Chinese liquor (60 degree) 1500g-2000g

Compound recipe Radix Angelicae Pubescentis indometacin capsules 0.3-0.5g

Embodiment 2

The consumption of each component of medicament A, B, C is in the described medicine: Agkistrodon 90g, Rhizoma Gastrodiae 150g, Rhizoma Chuanxiong 120g, Radix Angelicae Sinensis 120g, Chinese liquor 1800g, Fructus Canarii albi root 200g, native duck female 280g, water 1500g, compound recipe Radix Angelicae Pubescentis indometacin capsules 0.5g.

Claims (6)

1, a kind of medicine for the treatment of rheumatic, rheumatoid arthritis is characterized in that, described medicine is made up of medicament A, B, C:

The component of medicament A is prepared by following weight portion scope: 1500～2000 parts of the Chinese liquor of 55～90 parts of Agkistrodons, 90～150 parts in Rhizoma Gastrodiae, 100～120 parts of Rhizoma Chuanxiongs, 100～120 parts of Radix Angelicae Sinensis, 60 degree;

The component of medicament B is prepared by following weight portion scope: 150～200 parts of Fructus Canarii albi roots, 250～300 parts of the female meat of native duck, 1000～1500 parts in water;

The component that medicament C-compound recipe Radix Angelicae Pubescentis indometacin capsules is every is in the following weight parts scope: 50～55 parts of Radix Angelicae Pubescentiss, 50～55 parts of Rhizoma Et Radix Notopterygiis, 50～55 parts of Fructus Chaenomeliss, 50～55 parts of Radix Achyranthis Bidentataes, 25～30 parts of indomethacins, 10～20 parts of piroxicams.

2, a kind of medicine for the treatment of rheumatic, rheumatoid arthritis, it is characterized in that the consumption of described each component of medicine is: Agkistrodon 90g, Rhizoma Gastrodiae 150g, Rhizoma Chuanxiong 120g, Radix Angelicae Sinensis 120g, Chinese liquor 1800g, Fructus Canarii albi root 200g, the female meat 280g of native duck, water 1500g, compound recipe Radix Angelicae Pubescentis indometacin capsules 0.5g.

3, medicine according to claim 1 is characterized in that, the preparation method of described medicament A is: get the preparation in advance of Agkistrodon, Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, it comprises the following steps:

A. Agkistrodon meat is dried;

B. the Rhizoma Gastrodiae section is dried;

C. Rhizoma Chuanxiong, Chinese angelica slicing are dried;

D. by above-mentioned weight portion proportioning the medicament mixed of drying in the sun Agkistrodon meat and Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Angelicae Sinensis is developed into powder;

E. the medicated powder of pulverizing was immersed in 60 degree Chinese liquor 20～40 days;

F, method of Chinese medicinal are routinely made pill or powder or the tablet of medicament A.

4, medicine according to claim 1 is characterized in that, the preparation method of described medicament B is, gets Fructus Canarii albi root, the female meat of native duck, water by above-mentioned weight portion and concocts in advance, and it comprises the following steps:

A. Fructus Canarii albi undercut sheet is dried;

B. with the female meat section of native duck;

C. Fructus Canarii albi root, the female meat of native duck, water are mixed, slow fire steamed 45～70 minutes;

D, method of Chinese medicinal are routinely made liquid agent or pill or powder or tablet or capsule.

5, medicine according to claim 3 is characterized in that, in the preparation method of described medicament A the medicated powder of pulverizing is soaked 1 month in 60 degree Chinese liquor.

6, medicine according to claim 4 is characterized in that, in the preparation method of described medicament B Fructus Canarii albi root, the female meat of native duck, water is mixed, and slow fire steamed 1 hour.