KR20020057966A - 금속 결합 화합물 및 그의 용도 - Google Patents
금속 결합 화합물 및 그의 용도 Download PDFInfo
- Publication number
- KR20020057966A KR20020057966A KR1020027004228A KR20027004228A KR20020057966A KR 20020057966 A KR20020057966 A KR 20020057966A KR 1020027004228 A KR1020027004228 A KR 1020027004228A KR 20027004228 A KR20027004228 A KR 20027004228A KR 20020057966 A KR20020057966 A KR 20020057966A
- Authority
- KR
- South Korea
- Prior art keywords
- xaa
- peptide
- alanine
- amino acids
- hydroxymethylserine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 239000000047 product Substances 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 150000003214 pyranose derivatives Chemical class 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 229910001456 vanadium ion Inorganic materials 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15740499P | 1999-10-01 | 1999-10-01 | |
| US60/157,404 | 1999-10-01 | ||
| US21107800P | 2000-06-13 | 2000-06-13 | |
| US60/211,078 | 2000-06-13 | ||
| PCT/US2000/026952 WO2001025265A1 (en) | 1999-10-01 | 2000-09-29 | Metal-binding compounds and uses therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020097012559A Division KR101062041B1 (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20020057966A true KR20020057966A (ko) | 2002-07-12 |
Family
ID=26854102
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020027004228A Ceased KR20020057966A (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
| KR1020107008232A Ceased KR20100075503A (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
| KR1020097012559A Expired - Fee Related KR101062041B1 (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
| KR1020117006608A Ceased KR20110049875A (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
| KR1020117031646A Expired - Fee Related KR101353140B1 (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
| KR1020117031645A Expired - Fee Related KR101312880B1 (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107008232A Ceased KR20100075503A (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
| KR1020097012559A Expired - Fee Related KR101062041B1 (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
| KR1020117006608A Ceased KR20110049875A (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
| KR1020117031646A Expired - Fee Related KR101353140B1 (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
| KR1020117031645A Expired - Fee Related KR101312880B1 (ko) | 1999-10-01 | 2000-09-29 | 금속 결합 화합물 및 그의 용도 |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP1220870B1 (https=) |
| JP (1) | JP5349722B2 (https=) |
| KR (6) | KR20020057966A (https=) |
| CN (2) | CN102038932B (https=) |
| AT (1) | ATE553116T1 (https=) |
| AU (1) | AU770999C (https=) |
| BR (1) | BR0014389A (https=) |
| CA (1) | CA2385551A1 (https=) |
| IL (4) | IL148797A0 (https=) |
| NZ (1) | NZ518266A (https=) |
| WO (1) | WO2001025265A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020160417A1 (en) * | 2001-04-30 | 2002-10-31 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1424 daltons |
| US20030040602A1 (en) * | 2001-04-30 | 2003-02-27 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1406 daltons |
| WO2003043518A2 (en) * | 2001-11-20 | 2003-05-30 | Dmi Biosciences, Inc. | Methods and products for oral care |
| JP5204947B2 (ja) | 2002-11-27 | 2013-06-05 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | リン酸受容体化合物の使用、ならびにリン酸受容体化合物を含んでいる、薬学的組成物、スキンケア用の組成物、およびキット |
| JP5265762B2 (ja) | 2008-05-13 | 2013-08-14 | ユニバーシティ・オブ・カンザス | 金属抽出ペプチド（ｍａｐ）タグおよび関連する方法 |
| WO2013181461A2 (en) | 2012-06-01 | 2013-12-05 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
| CN112094316B (zh) * | 2017-06-29 | 2022-04-08 | 安徽省农业科学院农产品加工研究所 | 一种Ser和Cys分列在两端的高锌螯合活性锌鳌合肽及其应用 |
| AU2021400952A1 (en) * | 2020-12-15 | 2023-06-29 | Life Technologies Corporation | Chemically defined serum albumin substitutes |
| CN113563418B (zh) * | 2021-06-22 | 2023-03-03 | 中国科学院化学研究所 | 一种原位响应ros的人工酶及其制备方法与应用 |
| CN114437175B (zh) * | 2022-01-29 | 2023-09-29 | 山东第一医科大学第三附属医院(山东省医学科学院附属医院) | 一种肽探针及其应用和包含该肽探针的试剂盒 |
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| US3941763A (en) | 1975-03-28 | 1976-03-02 | American Home Products Corporation | PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates |
| US4022888A (en) | 1975-09-09 | 1977-05-10 | Diagnostic Data, Inc. | Esterified orgotein |
| US4461724A (en) | 1981-10-28 | 1984-07-24 | Nippon Zoki Pharmaceutical Co., Ltd. | Peptide compounds, a process for manufacturing them, pharmaceutical compositions containing them, and methods for treating ulcer and thrombus with them |
| US4912118A (en) | 1983-09-23 | 1990-03-27 | National Research Development Corporation | Pharmaceutical compositions |
| US4760051A (en) | 1985-01-24 | 1988-07-26 | Pickart Loren R | Use of GHL-Cu as a wound-healing and anti-inflammatory agent |
| US5120831A (en) | 1985-02-08 | 1992-06-09 | Procyte Corporation | Metal-peptide compositions |
| US5214032A (en) | 1985-02-08 | 1993-05-25 | Procyte Corporation | GHL-CU pharmaceutical compositions and compounds |
| US4877770A (en) | 1985-02-08 | 1989-10-31 | Procyte Corporation | Chemical derivatives of GHL-Cu |
| US4767753A (en) | 1985-02-08 | 1988-08-30 | Procyte Corporation | Methods and compositions for preventing ulcers |
| US4665054A (en) | 1985-02-08 | 1987-05-12 | Bioheal, Inc. | Chemical derivatives of GHL-Cu |
| US5177061A (en) | 1985-02-08 | 1993-01-05 | Procyte Corporation | Method for stimulating hair growth using GHL-Cu complexes |
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| US4810693A (en) | 1985-02-08 | 1989-03-07 | Procyte Corporation | Method for inducing biological coverings in wounds |
| US5348943A (en) | 1985-02-08 | 1994-09-20 | Procyte Corporation | Cosmetic and skin treatment compositions |
| US5422096A (en) | 1985-05-08 | 1995-06-06 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
| JPS62116565A (ja) * | 1985-11-15 | 1987-05-28 | Fujisawa Pharmaceut Co Ltd | 新規ペプチド |
| GB8603537D0 (en) | 1986-02-13 | 1986-03-19 | Parker D | Conjugate compound |
| CA1323839C (en) | 1987-05-11 | 1993-11-02 | Loren Ralph Pickart | Methods for stimulating hair growth |
| DE68917946T2 (de) | 1988-01-29 | 1995-01-05 | Peter H Proctor | Haarwachstumanregung mit Nitroxyd und anderen Radikalen. |
| US5101041A (en) | 1989-04-26 | 1992-03-31 | The Curators Of The University Of Missouri | Triamines and their derivatives as bifunctional chelating agents |
| US5443816A (en) | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| CA2065299C (en) | 1989-08-09 | 2001-07-24 | Buck A. Rhodes | Direct radiolabeling of antibodies and other proteins with technetium or rhenium |
| US5759515A (en) | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
| US5460785A (en) | 1989-08-09 | 1995-10-24 | Rhomed Incorporated | Direct labeling of antibodies and other protein with metal ions |
| US5023237A (en) | 1989-08-30 | 1991-06-11 | Procyte Corporation | Methods and compositions for healing ulcers |
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| US5059588A (en) | 1989-10-13 | 1991-10-22 | Procyte Corporation, Incorporated | Methods and compositions for healing bone using gly his lys: copper |
| US5118665A (en) | 1990-02-09 | 1992-06-02 | Procyte Corporation | Anti-oxidative and anti-inflammatory metal:peptide complexes and uses thereof |
| US5164367A (en) | 1990-03-26 | 1992-11-17 | Procyte Corporation | Method of using copper(ii) containing compounds to accelerate wound healing |
| US5252559A (en) | 1991-08-20 | 1993-10-12 | The Procter & Gamble Company | His-Gly-Gly peptide and derivatives thereof for hair growth |
| US5280038A (en) | 1992-03-13 | 1994-01-18 | Virginia Commonwealth University | Histidine as a protective agent in cardiac surgery and myocardial ischemic syndrome |
| CA2094785A1 (en) | 1992-05-08 | 1993-11-09 | Jean Gariepy | Metal chelating peptide |
| US5807535A (en) | 1992-07-31 | 1998-09-15 | Australian Nuclear Science & Technology Organisation | Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents |
| US5380747A (en) | 1992-10-30 | 1995-01-10 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
| US5650134A (en) | 1993-01-12 | 1997-07-22 | Novartis Ag (Formerly Sandoz Ltd.) | Peptides |
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| US5994339A (en) | 1993-10-15 | 1999-11-30 | University Of Alabama At Birmingham Research Foundation | Oxidant scavengers |
| US5476939A (en) | 1993-12-30 | 1995-12-19 | Abbott Laboratories | Certain pyridyl and isoquinolyl carbinolamine derivatives |
| JPH07316192A (ja) | 1994-05-27 | 1995-12-05 | Hoechst Japan Ltd | Ｌ−リシル−グリシル−ｌ−ヒスチジンおよびこれを含有する創傷治療剤 |
| US5538945A (en) | 1994-06-17 | 1996-07-23 | Procyte Corporation | Stimulation of hair growth by peptide copper complexes |
| US5891418A (en) | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| EP0955044B1 (en) | 1995-06-26 | 2005-11-16 | Chelator LLC | Method of inhibiting bacterial or fungal growth using a complexing agent |
| US5637311A (en) | 1995-06-29 | 1997-06-10 | Procyte Corporation | Zinc(II) complexes and methods related thereto |
| RU2106146C1 (ru) | 1995-07-17 | 1998-03-10 | Институт элементоорганических соединений РАН | Средство для подавления опухолевого роста |
| US5786335A (en) | 1995-11-06 | 1998-07-28 | Warner-Lambert Company | Sulfhydryl containing peptides for treating vascular disease |
| US5928955A (en) | 1996-03-22 | 1999-07-27 | California Institute Of Technology | Peptidyl fluorescent chemosensor for divalent zinc |
| WO1997044313A1 (en) | 1996-05-21 | 1997-11-27 | Novartis Ag | N,N'-Di(2-HYDROXYBENZYL)ETHYLENEDIAMINE-N,N'-DIACETIC ACID DERIVATIVES |
| GB9613182D0 (en) | 1996-06-24 | 1996-08-28 | Nycomed Imaging As | Method |
| PL184070B1 (pl) | 1996-07-30 | 2002-08-30 | Politechnika Lodzka | Sposób wytwarzania peptydów zawierających a-hydroksymetyloserynę |
| US5906996A (en) | 1996-08-21 | 1999-05-25 | Murphy; Michael A. | Tetramine treatment of neurological disorders |
| US5922761A (en) | 1996-09-06 | 1999-07-13 | Medinox, Inc. | Methods for in vivo reduction of iron levels and compositions useful therefor |
| US5739395A (en) | 1997-01-10 | 1998-04-14 | University Of Florida Research Foundation, Inc. | Method for synthesis of rhizoferrin |
| GB9711093D0 (en) | 1997-05-29 | 1997-07-23 | British Tech Group | Novel orally active iron (III) chelators |
| DE69922787T2 (de) | 1998-02-04 | 2005-12-15 | University of Florida Research Foundation, Inc., Gainesville | N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'-diessigsäure und natriumsalze davon zur eisenchelatierungstherapie |
| DE19819843A1 (de) | 1998-05-05 | 1999-11-11 | Biotechnolog Forschung Gmbh | Metallchelat bindende Peptide |
| CA2328457A1 (en) | 1998-06-20 | 1999-12-29 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
-
2000
- 2000-09-29 CN CN2010105807752A patent/CN102038932B/zh not_active Expired - Fee Related
- 2000-09-29 JP JP2001528205A patent/JP5349722B2/ja not_active Expired - Fee Related
- 2000-09-29 CN CN00815718A patent/CN1390231A/zh active Pending
- 2000-09-29 AT AT00967163T patent/ATE553116T1/de active
- 2000-09-29 EP EP00967163A patent/EP1220870B1/en not_active Expired - Lifetime
- 2000-09-29 EP EP10183238A patent/EP2327713A1/en not_active Withdrawn
- 2000-09-29 BR BR0014389-8A patent/BR0014389A/pt not_active IP Right Cessation
- 2000-09-29 KR KR1020027004228A patent/KR20020057966A/ko not_active Ceased
- 2000-09-29 KR KR1020107008232A patent/KR20100075503A/ko not_active Ceased
- 2000-09-29 IL IL14879700A patent/IL148797A0/xx unknown
- 2000-09-29 CA CA002385551A patent/CA2385551A1/en not_active Abandoned
- 2000-09-29 AU AU77407/00A patent/AU770999C/en not_active Ceased
- 2000-09-29 KR KR1020097012559A patent/KR101062041B1/ko not_active Expired - Fee Related
- 2000-09-29 KR KR1020117006608A patent/KR20110049875A/ko not_active Ceased
- 2000-09-29 WO PCT/US2000/026952 patent/WO2001025265A1/en not_active Ceased
- 2000-09-29 KR KR1020117031646A patent/KR101353140B1/ko not_active Expired - Fee Related
- 2000-09-29 KR KR1020117031645A patent/KR101312880B1/ko not_active Expired - Fee Related
- 2000-09-29 NZ NZ518266A patent/NZ518266A/en not_active IP Right Cessation
-
2002
- 2002-03-20 IL IL148797A patent/IL148797A/en not_active IP Right Cessation
-
2009
- 2009-12-17 IL IL202812A patent/IL202812A0/en unknown
-
2010
- 2010-09-01 IL IL207923A patent/IL207923A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL202812A0 (en) | 2011-07-31 |
| BR0014389A (pt) | 2002-10-29 |
| WO2001025265A1 (en) | 2001-04-12 |
| KR20100075503A (ko) | 2010-07-02 |
| EP1220870A4 (en) | 2004-04-07 |
| KR101353140B1 (ko) | 2014-01-20 |
| KR20120023147A (ko) | 2012-03-12 |
| IL207923A0 (en) | 2011-07-31 |
| JP5349722B2 (ja) | 2013-11-20 |
| ATE553116T1 (de) | 2012-04-15 |
| KR20110049875A (ko) | 2011-05-12 |
| CN102038932A (zh) | 2011-05-04 |
| KR101312880B1 (ko) | 2013-09-30 |
| IL148797A (en) | 2010-12-30 |
| CA2385551A1 (en) | 2001-04-12 |
| KR20120024890A (ko) | 2012-03-14 |
| HK1157635A1 (en) | 2012-07-06 |
| AU770999C (en) | 2005-04-21 |
| NZ518266A (en) | 2005-01-28 |
| CN1390231A (zh) | 2003-01-08 |
| AU7740700A (en) | 2001-05-10 |
| JP2003528814A (ja) | 2003-09-30 |
| CN102038932B (zh) | 2013-11-06 |
| IL148797A0 (en) | 2002-09-12 |
| EP2327713A1 (en) | 2011-06-01 |
| AU770999B2 (en) | 2004-03-11 |
| EP1220870A1 (en) | 2002-07-10 |
| KR20090086437A (ko) | 2009-08-12 |
| EP1220870B1 (en) | 2012-04-11 |
| KR101062041B1 (ko) | 2011-09-02 |
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