CN102038932B - 金属-结合性化合物及其用途 - Google Patents
金属-结合性化合物及其用途 Download PDFInfo
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- CN102038932B CN102038932B CN2010105807752A CN201010580775A CN102038932B CN 102038932 B CN102038932 B CN 102038932B CN 2010105807752 A CN2010105807752 A CN 2010105807752A CN 201010580775 A CN201010580775 A CN 201010580775A CN 102038932 B CN102038932 B CN 102038932B
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
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- Engineering & Computer Science (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Cu(II)∶D-四肽 | Cu(II)(μM) | 抗坏血酸(μM) | D-四肽(μM) | A532 | 抑制% |
1∶0 | 10 | 500 | 0 | 0.767 | |
4∶1 | 10 | 500 | 2.5 | 0.751 | |
2∶1 | 10 | 500 | 5 | 0.743 | |
1∶1 | 10 | 500 | 10 | 0.751 | |
4∶5 | 10 | 500 | 12.5 | 0.789 | |
2∶3 | 10 | 500 | 15 | 0.774 | |
4∶7 | 10 | 500 | 17.5 | 0.737 | |
1∶2 | 10 | 500 | 20 | 0.029 | 96.2 |
1∶4 | 10 | 500 | 40 | 0.016 | 97.9 |
Claims (10)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US15740499P | 1999-10-01 | 1999-10-01 | |
US60/157,404 | 1999-10-01 | ||
US21107800P | 2000-06-13 | 2000-06-13 | |
US60/211,078 | 2000-06-13 |
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CN00815718A Division CN1390231A (zh) | 1999-10-01 | 2000-09-29 | 金属-结合性化合物及其用途 |
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CN102038932A CN102038932A (zh) | 2011-05-04 |
CN102038932B true CN102038932B (zh) | 2013-11-06 |
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CN2010105807752A Expired - Fee Related CN102038932B (zh) | 1999-10-01 | 2000-09-29 | 金属-结合性化合物及其用途 |
CN00815718A Pending CN1390231A (zh) | 1999-10-01 | 2000-09-29 | 金属-结合性化合物及其用途 |
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CN00815718A Pending CN1390231A (zh) | 1999-10-01 | 2000-09-29 | 金属-结合性化合物及其用途 |
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JP (1) | JP5349722B2 (zh) |
KR (6) | KR20110049875A (zh) |
CN (2) | CN102038932B (zh) |
AT (1) | ATE553116T1 (zh) |
AU (1) | AU770999C (zh) |
BR (1) | BR0014389A (zh) |
CA (1) | CA2385551A1 (zh) |
HK (1) | HK1157635A1 (zh) |
IL (4) | IL148797A0 (zh) |
NZ (1) | NZ518266A (zh) |
WO (1) | WO2001025265A1 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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US20030040602A1 (en) * | 2001-04-30 | 2003-02-27 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1406 daltons |
US20020160417A1 (en) * | 2001-04-30 | 2002-10-31 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1424 daltons |
JP2005517636A (ja) * | 2001-11-20 | 2005-06-16 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | オーラル・ケアのための方法および製品 |
AU2003299568B2 (en) | 2002-11-27 | 2010-07-22 | Ampio Pharmaceuticals, Inc. | Treatment of diseases and conditions mediated by increased phosphorylation |
WO2009140408A2 (en) | 2008-05-13 | 2009-11-19 | University Of Kansas | Metal abstraction peptide (map) tag and associated methods |
US9187735B2 (en) | 2012-06-01 | 2015-11-17 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
CN107337709B (zh) * | 2017-06-29 | 2021-03-02 | 安徽省农业科学院农产品加工研究所 | 一种高锌螯合活性锌螯合肽及其应用 |
CN113563418B (zh) * | 2021-06-22 | 2023-03-03 | 中国科学院化学研究所 | 一种原位响应ros的人工酶及其制备方法与应用 |
CN114437175B (zh) * | 2022-01-29 | 2023-09-29 | 山东第一医科大学第三附属医院(山东省医学科学院附属医院) | 一种肽探针及其应用和包含该肽探针的试剂盒 |
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2002
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2003
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2009
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2010
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Title |
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Catherine Harford and Bibudhendra Sarkar.Amino Terminal Cu(II)-and Ni(II)-binding(ATCUN)motif of proteins and peptides:metal binding,DNA cleavage,and other properties.《Acc. Chem. Res.》.1997,第30卷123-130. * |
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AU770999C (en) | 2005-04-21 |
KR101062041B1 (ko) | 2011-09-02 |
KR101312880B1 (ko) | 2013-09-30 |
CN1390231A (zh) | 2003-01-08 |
IL207923A0 (en) | 2011-07-31 |
EP1220870B1 (en) | 2012-04-11 |
IL202812A0 (en) | 2011-07-31 |
KR20120023147A (ko) | 2012-03-12 |
WO2001025265A1 (en) | 2001-04-12 |
JP5349722B2 (ja) | 2013-11-20 |
EP1220870A4 (en) | 2004-04-07 |
JP2003528814A (ja) | 2003-09-30 |
IL148797A (en) | 2010-12-30 |
EP1220870A1 (en) | 2002-07-10 |
EP2327713A1 (en) | 2011-06-01 |
AU770999B2 (en) | 2004-03-11 |
IL148797A0 (en) | 2002-09-12 |
KR101353140B1 (ko) | 2014-01-20 |
KR20020057966A (ko) | 2002-07-12 |
ATE553116T1 (de) | 2012-04-15 |
BR0014389A (pt) | 2002-10-29 |
CA2385551A1 (en) | 2001-04-12 |
KR20120024890A (ko) | 2012-03-14 |
CN102038932A (zh) | 2011-05-04 |
KR20100075503A (ko) | 2010-07-02 |
NZ518266A (en) | 2005-01-28 |
KR20110049875A (ko) | 2011-05-12 |
HK1157635A1 (en) | 2012-07-06 |
AU7740700A (en) | 2001-05-10 |
KR20090086437A (ko) | 2009-08-12 |
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