KR20010066713A - A process for preparing a diet ginseng products - Google Patents

Abstract

PURPOSE: A method for preparing a dietary product such by using ginseng and kinds of herbal materials capable of reducing body fat is provided to prevent and treat obesity by losing ones body weight with minimized side effects. CONSTITUTION: The method includes the following steps of: (i) getting herb extract of which solid is 64% by mixing and extracting 1-5% of Acanthopanacis Cortex, 1-5% of Eucommia ulmoides olive, 0.2-1.0% of Angelica gigas Nakai, 0.2-0.8% of Rehmanniae Radix Preparata, 1-5% of leaves of Camellia sinensis and 0.3-1% of mulberry leaves with 7-15times of refined water at 60-90deg.C for 5hr 2times, centrifuging the solution at 5-10deg.C at a rate of 8000rpm for 20min. and vacuum concentrating the supernatant at less than 10deg.C; (ii) mixing 0.3-0.6% of the herb extract with functional aids such as 0.001-0.004% of Thiamin HCL, 0.001-0.004% of riboflavin Na-P, 0.008-0.012% of Pyridoxine HCl, 0.06-0.1% of citric acid, 3-10% of polydextrose or 0.2-1.0% of silk peptide and 1-2.5% of maltitol and 0.05-0.2% of fruit mix or 0.03-0.09% of lemon flavor and 0.01-0.08% of raspberry flavor; (iii) adding refined water to the resulting mixed extract to 100% of total volume and filling the solution in a container. The herb extract can be mixed with 30-50% of crystal cellulose and 60-80% alcohol, dried at 60-80deg.C for 20-30hrs and pulverized and filled in a hard capsule or the pulverized herb extract can be granulated into 10-30mesh, dehydrated at 50-80deg.C for 20-30hrs, mixed with 1-3% of sodium carboxy methyl starch and 0.5-2% of Mg-stearate and then produced in a tablet shape.

Description

A process for preparing a diet ginseng products

The present invention relates to a ginseng product for diet, and more specifically, 12 kinds of herbal medicines that were frequently used among over 40 herbal prescriptions among obesity-relieving herbal medicines used in herbal prescriptions to suppress appetite, diuresis, and body fat reduction. And herbal medicines that are known to be effective in supplementing health and especially ginseng and tortoise which have the effect of compensating for the energy consumption resulting from weight loss while promoting the release of absorbed energy. After mixing ginseng mixed product to confirm the weight loss effect by animal experiments, it is clinically confirmed by the medical institution to check the weight loss effect and to develop a convenient drink, capsule (tablet), tablet products .

The development of civilization for convenience brought the lack of exercise to the human body, and the development of high-calorie instant foods made from Western meats has made the human body obese and high cholesterol. Obesity has become a serious health problem in Korea as well as in the West, where meat is a staple food, and methods for preventing and treating obesity are being studied in various aspects of the world, and the method is a calorie-restricted diet that limits calorie intake. , Exercise therapy, surgical therapy and drug therapy using appetite suppressants or energy metabolism accelerators have been proposed, but they are not used as effectively as expected for various reasons.

In the case of calorie-restricted diets, it is difficult to overcome the temptations of food and the urge to habitual food intake in modern life where a wide variety of foods are readily available everywhere in daily life. In the case of exercise therapy, the obese person has not gained a great effect from the obese person because it is difficult to continue the exercise for a sufficient amount of time due to the excessive weight. Even if the weight is lost by diet or exercise therapy, diet and exercise therapy should be carried out steadily in order to maintain the weight loss. Otherwise, there is a problem such as the yo-yo phenomenon of weight gain. Even by the methods, a great effect is difficult to expect. Various appetite suppressants or energy metabolic accelerators have been proposed, but most of these drugs have serious side effects, and in some cases, the efficacy of these drugs is not clearly identified. Currently, studies are being actively conducted in the West to compensate for the shortcomings of the methods described above for the treatment of obesity. In particular, the energy metabolic accelerators have been actively studied in this field because of the advantage that weight gain effect can be obtained without limiting caloric intake. However, all of the energy metabolic accelerators developed to date suffer from serious side effects. If such a drug is put to practical use, it is highly prone to long-term dependence on the drug, so the side effects of drug use are recognized as serious problems. In this respect, it is urgent to develop drugs that can significantly increase energy metabolism without accompanying side effects, and the prospect is very opaque at present.

Obesity is a metabolic disease caused by an imbalance between calorie intake and consumption, which can be defined as an increased state of adipose tissue. Recently, in Korea, the calorie intake is increasing due to the improvement of diet and the westernization of food due to the rapid economic development. Obesity is not only psychologically and socially atrophy of the individual, but also known to be an important factor to increase the risk of hypertension, arteriosclerosis, diabetes.

In the body, in order to prevent the development and progression of obesity, the center of gravity, which detects the increase and decrease of body weight, is present in the hypothalamus, and by the powerful feedback action, the body maintains a constant weight of fat tissue. However, the specific mechanism of this physiological control mechanism is not yet known.

The sympathetic nervous system promotes fat metabolism and glucose metabolism in the brown adipose tissue, an energy consuming organ, to increase metabolic heat production capacity. The action of the sympathetic nerves to increase energy consumption is known to be expressed mainly via betatriadrenaline ( β ₃ adrenaline) receptors present in these tissues. The effect of catecholamine through the important betatriadrenaline ( β ₃ adrenaline) receptor in brown adipose tissue is to promote lipolysis. As a result, triglycerides stored in brown and white adipose tissue are mobilized as fatty acids and oxidized in the de-conjugated proteins of mitochondria of white adipose tissue and consumed by heat production. Eventually, catecholamines are thought to act to regulate the consumption of stored triglycerides, consuming excess energy in the body through heat production. Therefore, if the function of the sympathetic nervous system or the beta-triadrenaline ( β ₃ adrenaline) receptor is abnormal, the energy consumption in the body is expected to cause obesity. Therefore, the possibility that agents that stimulate beta-adrenergic tree (β ₃ adrenaline) receptors of the sympathetic used as a new treatment of obesity and is being conducted extensive research on the metabolic heat accelerator in Western countries. However, the synthetic drugs currently being studied do not act purely on adipose tissue, but can act on cardiovascular system and cause tachycardia and blood pressure increase.

Most domestically marketed products for weight loss are indigestible polysaccharides, which are made from some herbal medicines that are dependent on imported materials or have effects such as appetite suppression and diuresis, but reported that they resulted in substantial weight loss without side effects. Is not yet.

The present invention is to solve the problems of the conventional obesity treatment, to develop an obesity treatment that can effectively lower body fat without side effects on the heart and circulatory system effective in the treatment of obesity difficult to control only diet and exercise therapy It relates to the manufacture of functional foods.

The cause of obesity is due to the imbalance of nutrients ingested and the amount of calories that are not consumed accumulate in the body. It is known that body fat accumulates according to defects of adrenaline receptors and innate qualities and constitutions. Among Korean traditional medicines that have been used traditionally in Korea, drugs that have sympathetic nerve activity regulating mechanisms are known, and in applying their effective prescriptions for the treatment of obesity, total saponin among ginseng components is the absorption of sugar and cholesterol from the stomach. It has the function of promoting the dissipation of absorbed energy and at the same time, it has indirect obesity prevention effect and also ginseng is used to prevent energy loss when losing weight in oriental medicine, which is based on ginseng and has anti-obesity effect It is an object of the present invention to develop an anti-obesity composite product exhibiting a synergistic effect by the addition.

In order to achieve this purpose, in the selection and use of herbal medicines that can be used to treat obesity without side effects, Korea has been developing oriental medicine and folk medicine considerably while belonging to Oriental medicine. Recently, herbal medicine used in oriental medicine and folk medicine As they show excellent physiological activity and no side effects, they are increasingly interested in oriental medicine and folk medicine, and efforts to scientificize them are urgently required.

However, as far as substances related to the prevention and treatment of obesity in oriental medicine and folk remedies are known, many are known by oral rather than the literature, and there are not many studies reported using them for the prevention and treatment of obesity.

Therefore, in the present invention, the anti-obesity effect of the anticipated anti-obesity effect of the anti-obesity effect is verified based on all the information in the literature and the word of mouth. The purpose of this study is to consider the negative effects of consumers due to excessive dietary restrictions, diuretics, and other side effects, and the yo-yo phenomenon that increases body weight when stopping taking calories. The basic concept is to develop obesity prevention or therapeutic products that can reduce weight by promoting consumption by metabolites.

The 12 kinds of herbal medicines selected primarily for the treatment of obesity are used frequently, and their functions are known to have high appetite suppression, diuresis, body fat reduction and stabilizing effect, especially for ginseng. It promotes the dissipation of energy and complements the stamina consumption from weight loss, and it is also found to have a haptic effect in Angelica, Ogapi, Sukjihwang, and green tea, including two larvae. It is a herbal medicine that is recognized as a weight loss effect by administering to the experimental animals (Sprague dawley: 200 ± 5g♂). After adding the expected vitamins to produce a composite prescription product, the effect is confirmed by animal experiments It is a feature of the present invention to manufacture beverages, capsules, tablets (Tablet) products confirmed by the haptic effect in the human body.

1 is a ginseng beverage manufacturing process of the present invention

2 is a ginseng capsule, tablet production process of the present invention

Figure 3 is a ginseng saponin pattern for each beverage, capsule, tablet products of the ginseng product of the present invention

As a preferred method for expressing the efficacy of anti-obesity products, low-calorie diet, energy metabolism accelerator, and nutritional absorption inhibitor are used as basic directions, and the effect of reducing ginseng fat on body fat It is to select herbal medicines and functional ingredients to search for their efficacy and to develop ginseng and anti-obesity products at the level of fat containing the body fat resolution of each of these herbal medicines.

Dietary fiber functional material and obesity-relieving herbal medicines in the selection of raw materials Among the 44 herbal prescriptions among 44 herbal prescriptions, the herbal medicines found in animal experiments were found to be effective in reducing obesity. The formulation of the product, the direction of manufacture and the optimum formulation conditions of the contents were set.

Functional materials include materials such as polydextrose or crystalline celluose, which are indigestible polysaccharides, to promote digestive tract movement, to provide satiety, to suppress appetite, to absorb nutrients, and to promote intestinal contents. And nutrient source of intestinal microorganisms to promote intestinal action by total flora.

For herbal medicines, the first experiment was conducted on the physicochemical components of the herbal medicines by the Ginseng and Tobacco Research Institute, and the animal experiments (Department of Food and Nutrition, Kunsan National University) and clinical experiment (Gunsan University) were combined with individually selected herbal medicines as a basis. School of Medicine).

In the experiments on anti-obesity by herbal medicines, the old prescription, bodily sensation of bodily sensation, bodily sensation dehumidification bath, bodily sensation qitang, bodily sensation Botang, bodily sensation guktangtang, bodily sensation defense Tongseong-san, Banggi Hwanggi-tang, Kamibanha-tang, etc. The experimental herbal materials used were ginseng, tree barrel, yellow ginseng, safflower, joiner, donkey, cheongung, baekboknyeong, licorice, ogapi, tofu, and chason water-soluble extract dry powder. dawley, ♂, weight 200 ± 5g) were used to investigate the changes in triglyceride (TG) and cholesterol contents, including body weight, body fat content and energy consumption for 14 days.

Herbal medicines that have been found to have anti-obesity effects through animal experiments include ginseng extract, ogapi, tofu, Angelica, sage, and green tea. These ginseng complexes, each of which was selected as a medicinal herb, were evaluated for 14 days in animal experiments at the Department of Food and Nutrition, Kunsan National University. Clinical experiments were carried out in this study to confirm that the herbal medicine selected herein has a body fat reducing effect and no side effects on the human body was used as a raw material of the ginseng composite product of the present invention.

In the properties of the herbal medicines and subsidiary ingredients added to the ginseng composite product of the present invention, ginseng and herbal medicines Angelica, Dougong, Ogapi, Sukjihwang, green tea, as described above, the anti-obesity effect was confirmed by animal and clinical experiments, It has the effect of enhancing energy activity of cells and lowering cholesterol in blood (Anti-obesity effect was also confirmed in Kyung Hee University Medical School with upper leaf as a component of ginseng complex). It is especially effective in activating lipid metabolism and reducing body fat. (Japan Agricultural Research and Development Institute, 393rd Conference of the 3rd Conference of the Society of Agricultural Science, 1995) Silk peptide is used as a diabetic food as a water-soluble powder. It lowers cholesterol and supplies natural amino acids. Citric acid is a glycogen under the action of phosphoprokinase. It inhibits degradation and increases the synthesis efficiency of glycogen (J. Nutr. Sci. Vitaminol 32: 343-353, 1986), and maltitol is stable to heat, acid and alkali, has a soft and mild sweetness and is indigestible It has the effect of non-cavity, so it was used as raw material of ginseng composite product.

The formulation of the present invention was made into beverages, capsules and tablet products in consideration of the convenience of taking and carrying by the consumer, based on the scientific research results and literature as described above.

Beverage products include ginseng extract (produced by Korea Ginseng Corporation) and water-soluble extracts of herbal medicines that have been proven to have an obesity effect, leaf extract, poly-dextrose, crystalline cellulose, and silk peptides. The first prototypes were prepared using peptides, vitamins, sweeteners, flavors, etc., and then the sensory tests were conducted several times to select the ingredients and ratios of the final product.

Ginseng extract (Ginseng Corp. product) was used for capsules and tablets, and herbal extracts were extracted from Ogapi, tofu, Angelica, Baekbokryeong, and upper leaf as extract or concentrate (Ext, 70 ~ 80。Bx, water 30 ~ 40%). It was used after the preparation, and using the crystalline cellulose as an excipient in consideration of formulation suitability, organoleptic properties, manufacturing characteristics, quality characteristics, etc. The formulation components and ratios of the final product were selected as shown in Table 2 below.

In addition, the manufacturing process of the beverage and capsule and tablet of the ginseng composite product is the same as Figures 1 and 2 and describes the manufacturing method for each product as follows.

The beverage manufacturing method of ginseng composite product is to extract and concentrate the raw materials of herbal medicines, and the extract extract consists of 1 ~ 5% of Ogapi, 1 ~ 5% of Tofu, 0.2 ~ 1.0% of Angelica, 0.2 ~ 0.8% of Sukji, 0.2 ~ 0.8% of green tea. Weigh the herbal medicine ingredients to 5% and 0.3-1% of the upper leaf extract, add 10 times purified water, extract twice at 60-90 ℃ for 5 hours, collect the extracts, and centrifuge for 20 minutes at 5-10 ℃ and 8.000rpm. The supernatant was concentrated under reduced pressure up to 36% of water content at 60 ℃ or lower, and weighed and mixed with ginseng extract (Ext solid content 64%,), functional supplements and flavors according to the proportions of the ingredients as shown in Table 1, and then the filtrate was heated at 93 ℃. Instant sterilization for 15 seconds, then filled into a container, sterilized for 20 minutes at 80 ℃, then packaged into a product.

On the other hand, instead of adding 3-10% of polydextrose (Type A beverage), 0.2-1.0% of silk peptide (Type B beverage) can be added and mixed in fragrance. Rather than adding 0.05 to 0.2% of fruit mix (type A beverage), 0.03 to 0.09% of lemon flavor and 0.01 to 0.08% of raspberry (Type B beverage) were added.

The method of manufacturing capsules of ginseng composite products is 15-20% based on extract powder of ginseng extract (Ext, Korea Ginseng Corp.) and the herbal medicines are extracted and concentrated in the same way as in the beverage production of the ginseng composite product. 60-80% of the herbal extracts (Ext. 30-40 ° Bx, water 25-35%) prepared by mixing the herbal medicines so that the blending ratio of the extract powder of the herbal medicines for manufacture are as shown in Table 2. After mixing with alcohol using a mixer, it is dried for 20 to 30 hours at 60 ~ 80 ℃ and then pulverized (20 ~ 50 mesh or less) to fill the capsule. In the manufacture of tablet products of ginseng composite products, the powder for capsule manufacture is granulated (60mesh) with 60-80% alcohol, dried at 50-80 ℃ for 20-30 hours, the dried granules are selected to a certain size, and then disintegration aid (Sodium carboxy). Add 1 to 3% of methyl starch), 0.5 to 2% of Mg-stearate, etc., and make the final compounding amount for each component as shown in Table 2, and tablet it so that the weight is about 200 mg.

The characteristics of beverages, capsules, and tablets of ginseng composite products prepared using ginseng extracts, herbal medicines, anti-obesity functional materials, and other auxiliary ingredients for which weight loss is confirmed are shown in Table 3.

The ginseng saponin pattern according to the beverage, capsule, and tablet products of the ginseng composite product is shown in FIG. 3.

Ginseng extract increased appetite, but body fat did not change when ginseng extract powder was added to high-fat diet prepared separately in primary experimental animals. It was found that the amount of calories consumed is not accumulated as body fat, but the calorie consumption is increased by ginseng extract, so there is no change in body fat accumulation. This result indicates that ginseng extract has an effect of reducing body fat, and when the appetite suppression by ginseng extract is artificially reduced, substantial body fat accumulation due to calorie consumption decreases. In addition, in order to confirm the anti-obesity effect of the 12 selected herbal medicines, the water-soluble extracts were added to the high fat diet by 1%, respectively. It has been confirmed that there are some anti-obesity effects in Dongguk, Hwanggi, and Paekbokyeong.

In this experiment, the raw herbal medicine with body fat reduction effect was used as a ginseng compound, and the animal experiment was conducted at the Department of Food and Nutrition, Kunsan National University, and the clinical experiment was performed on the human body at the College of Medicine, Kyung Hee University. The effect was elucidated.

According to the study on the anti-obesity natural product search and body fat reduction effect of ginseng complex product of the present invention, which was conducted at Kunsan National University (Professor Ju Jong-jae, Department of Food and Nutrition), Ginseng complex prescription increased body fat. Two weeks of anti-obesity effects of ginseng complexes in animals (sprague-dawley male rats) were found. In general, complex prescriptions did not significantly reduce body fat accumulation. However, the combination prescription increased energy intake through food intake, but the increase in energy intake did not lead to an increase in body fat accumulation. In addition, the anti-obesity effect of ginseng complex products is suppressed when the increase of energy intake is suppressed. (Pair-feeding: two dogs are fed free and one ginseng is restricted to normal levels) Experimental results show that the multi-prescription drug reduces body fat by reducing body weight by 23% and body fat accumulation by 45%, which is achieved by increasing the consumption up to the accumulated energy rather than the energy consumed. The increase of is thought to be closely related to the activity of the sympathetic nervous system by multiprescription. In conclusion, the ginseng complex prescription developed in this study has a strong anti-obesity effect. It is found to be very effective if used in combination with proper diet control in practical terms.

On the other hand, an experiment on the effect of ginseng complex products on body fat reduction in obesity, conducted by Kyung Hee University College of Medicine (Dr. Obese patients with over 30% body fat were administered to observe the effect of reducing body fat, and the safety of the drug was investigated. For 20 obese patients, 4 weeks of diet, 4 weeks of diet and ginseng combination therapy were administered. The result was a 3.7% reduction from 70.04kg to 67.43kg, a 4.1% decrease in body mass index (BMI) from 27.12 to 26.01, a 1.47% decrease in waist / hip circumference ratio 0.8855 to 0.8758, and body fat from 35.16% to 31.68%. There was a significant decrease of 9.9%. In addition, no significant changes were found in the biochemical tests before and after the administration to see if there were serious adverse effects on the medications. A few patients complained of sympathetic and gastrointestinal symptoms. The amount was slight. Plasma epinephrine (hormone secreted by the adrenal cortex) increased to 0.27 dl / ml in the endocrinological examination, and the weight loss caused by ginseng complex products is thought to be caused by the sympathetic nervous system rather than the adrenal gland.

In conclusion, administration of ginseng complex in obese patients showed a significant weight loss effect when combined with diet, and there were few side effects.

In conclusion, the ginseng complex of the present invention acts on the sympathetic nervous system without side effects, increases energy consumption and reduces weight loss, especially in combination with diet. If you can lose weight effectively.

Claims (6)

Extracted and concentrated by blending raw materials of herbal medicines, the composition of the extract extract (solid content 64%) of Ogapi extract 1-5%, soybean extract 1-5%, Angelica extract 0.2-1.0%, sorghum sulfur extract 0.2-0.8%, green tea The herbal medicines were weighed and mixed so as to extract 1 to 5% of the extract and 0.3 to 1% of the leaf extract, and 7 to 15 times the amount of purified water was added and extracted twice at 60 to 90 ° C for 5 hours. The extracts were collected at 5 to 10 ° C and 8.000 rpm. The supernatant centrifuged for 20 minutes was concentrated under reduced pressure at 60 ° C. or lower, and the herbal extract (Ext solid 64%), ginseng extract (Ext, 64% solids) 0.3-0.6%, and hydrochloric acid amine 0.001-0.004%. Riboflavin Na-P 0.001-0.004%, pyridoxine hydrochloride 0.008-0.012%, citric acid 0.06-0.1%, polydextrose 3-10% (or Silk peptide 0.2-1.0 %), Functional supplements such as maltitol 1-2.5%, fruit mix flavor 0.05-0.2% (or lemon flavor 0.03-0.09% and raspberry flavor 0.01-0.08%) After weighing and mixing the fragrance of the method of producing a diet ginseng composite beverage, characterized in that to fill the container so that the final amount is 100%. Extract and concentrate ginseng extract (Ext.) By extract powder based on 15 ~ 20% extract and herbal medicine by the method of 1, but the composition ratio of extract powder of each herbal medicine is 3-9% of Ogapi extract powder and 3-9 extract of Dougong extract powder. Medicinal herb extract (Ext, 25 to 35% moisture), 3 to 9% of Angelica Extract powder, 3 to 9% of Sukji Hwang Extract, 7 to 17% of Green Tea Extract powder, 3 to 9% of Leaf Extract. , 30 ~ 40。Bx) And 30 ~ 50% crystalline cellulose is mixed with 60 ~ 80% alcohol, dried at 60 ~ 80 ℃ for 20 ~ 30 hours, pulverized to 20 ~ 50mesh, and then filled into capsule Diet ginseng composite capsule manufacturing method. Extract and concentrate ginseng extract (Ext) based on extract powder based on 15 ~ 20% and herbal medicine according to the method of claim 1, but the composition ratio of extract powder of herbal medicine is 3-9% of Ogapi extract powder and 3-9% of Dougong extract powder. Medicinal herb extract (Ext, 25-35% moisture, 3 ~ 9%), Angelica extract powder 3-9%, Sookji-hwang extract powder 3-9%, Green tea extract powder 7-17%, Upper leaf extract powder 3-9% 30 to 40 ° Bx), and 30 to 50% of crystalline cellulose was mixed with 60 to 80% alcohol, dried at 50 to 80 ° C for 20 to 30 hours, and then pulverized to 20 to 50 mesh. Granules were prepared to be 10-30 mesh, dried at 50-80 ° C. for 20-30 hours, dried granules were formed to a certain size, and then 1 to 3% of Sodium carboxy methyl starch and lubricant (Mg-stearate). 0.5 to 2% of the mixture is added, followed by tableting with a tablet, characterized in that Ginseng Complex Brett diet other method. Herb extract (1-5%), Dougong extract (1-5%), Angelica extract (0.2-1.0%), Sukji sulfur extract (0.2-0.8%), green tea extract (1-5%), leaf extract (0.3-1%), herbal extract (Ext solid content 64%) Ginseng extract (Ext, solid content 64%) 0.3-0.6%, and hydrochloric acid amine 0.001-0.004%. Riboflavin Na-P 0.001-0.004%, pyridoxine hydrochloride 0.008-0.012%, citric acid 0.06-0.1%, polydextrose 3-10% (or Silk peptide 0.2-1.0 %), Functional supplements such as maltitol 1-2.5%, fruit mix flavor 0.05-0.2% (or lemon flavor 0.03-0.09% and raspberry flavor 0.01-0.08%) After mixing the flavor of the diet ginseng complex drink characterized in that the final amount of purified water filled in a container and sterilized. 15 ~ 20% of ginseng extract (Ext.) Based on extract powder, and the composition ratio of extract powder of herbal medicine is 3 ~ 9% of Ogapi extract powder, 3-9% of Dougong extract powder, 3 ~ 9% of Angelica extract powder, and sulfuric acid sulfur extract 3 to 9% of powder, 7 to 17% of green tea extract powder, 3 to 9% of leaf extract powder, 30 to 50% of crystalline cellulose mixed with 60 to 80% alcohol, dried and ground to 20 to 50 mesh Diet ginseng composite capsule, characterized in that the filling in the capsule. 15-20% of ginseng extract (Ext) based on extract powder and 3 ~ 9% of extract powder of medicinal herb extract, 3-9% of Ogapi extract powder, 3-9% of Dougong extract powder, 3-9% of Angelica extract powder, sulfuric acid sulfur powder 3 to 9%, green tea extract powder 7 to 17%, leaf extract powder 3 to 9%, 30 to 50% of crystalline cellulose mixed with 60 to 80% alcohol, dried and ground to a powder of 20 to 50 mesh Granules to 10-30 mesh with alcohol and dried to add 1-5% of Sodium carboxy methyl starch and 0.5-2% of Mg-stearate, followed by tableting with tablets. Diet ginseng complex tablet to make.