KR20020089251A - A composition applicable to a skin for diet and an application thereof - Google Patents

Abstract

PURPOSE: A diet composition containing components acting on decomposition and excretion of neutral lipid in adipocyte cells is provided. A patch agent composition containing the diet composition enhances physiological activity of human body while achieving weight loss. CONSTITUTION: The patch agent composition comprises a matrix layer of a diet composition containing 0.05 to 5% by weight of ginkgo leaf extracts, 0.05 to 5% by weight of ginseng extracts, 0.05 to 5% by weight of lemon extracts, 0.05 to 5% by weight of Eriobotrya japonica extracts, 0.05 to 5% by weight of seaweed extracts, 0.05 to 5% by weight of jujube extracts, 0.05 to 5% by weight of a Rubus idaeus L. var. concolor Nakai extracts, 0.05 to 5% by weight of tourmaline, 5 to 10% by weight of mugwort powder, 20 to 40% by weight of potato starch, 0.01 to 0.03% by weight of caffeine, 50 to 70% by weight of seawater dried products, 2 to 5% by weight of sodium salt products of acrylic acid polymers and purified water.

Description

Composition and patch for patch useful for diet {A COMPOSITION APPLICABLE TO A SKIN FOR DIET AND AN APPLICATION THEREOF}

The present invention is a diet containing ginkgo biloba extract, ginseng extract, lemon extract, loquat extract, seaweed extract, jujube extract, raspberry extract, trumarin, mugwort powder, potato starch, caffeine, seawater dried, acrylic acid polymer partial sodium salt crosslinked product A composition useful for and a patch comprising the same. More specifically, as an active ingredient, 0.05-5% by weight of ginkgo leaf extract, 0.05-5% by weight ginseng extract, 0.05-5% by weight lemon extract, 0.05-5% by weight loquat extract, 0.05-5% by weight seaweed extract, jujube extract 0.05-5% by weight, Raspberry extract 0.05-5%, Trumarin 0.05-5%, Mugwort powder 5-10%, Potato starch 20-40%, Caffeine 0.01-0.03%, Seawater dried 50- By preparing a transdermal administration composition containing 70% by weight, 2-5% by weight of the acrylic acid polymer partial sodium salt crosslinking, and the remainder of the purified water and formulating it as a patch, the process of lipolysis and excretion in fat cells through skin absorption The present invention relates to a composition for patch and a patch useful for a diet to promote.

The composition and the patch of the present invention have an excellent effect on the weight loss effect, that is, the treatment and prevention of obesity by effectively removing body fat without side effects.

On the other hand, the average life expectancy of people is prolonged as nutritional intake is improved and dietary conditions are improved, while obesity patients are rapidly increasing every year due to westernization of food, excessive intake of food, physical exercise shortage and stress. There is a trend. Obesity, the product of this modern civilization, means an excess accumulation of body fat. Obesity is primarily caused by an excess of energy. That is, when the amount of calories ingested exceeds the energy consumption, the extra energy is converted into fat and stored in fat cells and fat tissue. It is obesity that persists.

Obesity can be classified according to the number and type of adipocytes. 'Hyperplasia Obesity', which increases the size and number of cells that store fat, appears mainly in childhood. 'Hypertrophy Obesity', which grows in size with no change in the number of cells, accounts for most of adult and pregnant obesity, and is highly related to hyperlipidemia, diabetes and cardiovascular sclerosis.

Depending on the area of obesity, obese obesity in which fat is distributed throughout the body, including the extremities; Peripheral (feminine) obesity where fat accumulates in the hips, thighs, breasts, and pelvic centers; Central (male) obesity, in which fat accumulates in the chest, abdomen, and arms.

In general, the active tissue of the normal weight is formed of 60% moisture, 17% protein, 5% ash, 18% body fat, when the body fat exceeds 30% is obese.

An analysis of obesity, which increases the risk of lifestyle-related diseases caused by obesity, shows that the BMI index (weight (Kg) divided by height (m) divided by 19 or less than 23): normal weight, 23 or more Under 29: overweight, over 29: obese) and diabetes, hyperlipidemia, hyperuricemia, hypertension, ischemic heart disease, cerebrovascular disorders, etc. In particular, in diabetes, a BMI index of 26 or higher increases significantly. People around the BMI index 26 are in fact overdosed at high risk of energy intake. Obesity is not only a matter of appearance, but also a serious problem directly related to health.

As obesity emerged as a problem in modern society, the term diet has attracted many people living in modern times. There are a number of dieting methods that have been introduced to date, taking advantage of the high interest and effort of obese people to lose weight. For example, fasting and fasting, vegetable enzymes, liposuction, diarrhea, diuretics, apple diets, grape diets, emperor diets, dietary fiber intake, moxibustion, far-infrared sauna suits, toning systems, etc. Although there is a temporary weight loss effect, the precise and scientific cause of the diet, the mechanisms of metabolism and the nutritional physiological approach to the diet are neglected and indiscriminately focused on the effects of weight loss, resulting in imbalances in nutrient intake. Metabolism is not normal, so it is easy to give a significant amount to the body. Therefore, when the diet is carried out by nourishing the nutrients needed by the body as a whole does not fail and do not gain weight again.

However, the general public is interested in simple and effective obesity treatments. The method used in the diet is a drug therapy using an appetite suppressant such as an amphetamine derivative. The drug therapy does not sustain an appetite suppressing ability and causes temporary effects such as headache, insomnia, increased blood pressure, insomnia, anxiety, nervousness, and hallucinations. Causes side effects, such as dizziness and decreased vision. In addition, diuretics are used to reduce and control weight, but this method also causes side effects such as addictiveness, heart attack, and vomiting for the patient. In addition, there is a central appetite suppressant that acts on the brain to suppress appetite, which is excellent in weight loss, but after a certain amount of time, resistance to the drug develops, so that the weight almost never decreases, and headache, insomnia It often causes side effects such as dizziness.

Therefore, there is an urgent need to develop products for permanent weight loss, smooth weight loss, loss of body fat, obesity treatment and prevention using natural ingredients.

Therefore, the present inventors have solved various problems such as causing side effects of the conventional oral diet medicine or food, and maintaining a healthy skin elasticity and good condition, while studying a long time for an effective diet product that can solve obesity As a result, by formulating components that act on triglyceride breakdown and excretion in adipocytes, a diet composition for transdermal administration and a patch including the same were developed.

Therefore, the present invention supplements the problems of conventional diet products and methods, improves side effects due to nutrient imbalance, yo-yo phenomenon, and the like, and contains a composition containing components that promote the process of decomposition and excretion of fat cells. Formulated with a transdermal patch that is directly in communication with the body, localized obesity, including side hips, thighs, recesses above the radius, navel areas of the abdomen, chest and shoulders, to the numbs Make it possible.

Compositions useful in the diet of the present invention for achieving the above object, ginkgo biloba extract 0.05 ~ 5% by weight, ginseng extract 0.05 ~ 5% by weight, lemon extract 0.05 ~ 5% by weight, loquat extract 0.05 ~ 5% by weight, Seaweed Extract 0.05 ~ 5%, Jujube Extract 0.05 ~ 5%, Raspberry Extract 0.05 ~ 5%, Trumarin 0.05 ~ 5%, Mugwort Powder 5.00 ~ 10%, Potato Starch 20 ~ 40%, Caffeine 0.01 to 0.03% by weight, seawater dry matter 50 to 70% by weight, acrylic acid polymer partial sodium salt crosslinked material 2 to 5% by weight and the remainder comprises purified water.

The patch of the present invention for achieving the above object is obtained by preparing a composition comprising the active ingredient and formulating it into a patch.

Figure 1 is a schematic diagram showing the steps of each active ingredient of the present invention in the process of synthesis, decomposition and excretion of fat components to explain the principle of the invention.

The present invention as an active ingredient ginkgo biloba extract 0.05 ~ 5% by weight, ginseng extract 0.05 ~ 5% by weight, lemon extract 0.05 ~ 5% by weight, loquat extract 0.05 ~ 5% by weight, seaweed extract 0.05 ~ 5% by weight, jujube extract 0.05 ~ 5% by weight, Raspberry extract 0.05-5%, Trumarin 0.05-5%, Mugwort powder 5-10%, Potato starch 20-40%, Caffeine 0.01-0.03%, Seawater dry matter 50-70% A composition useful for a diet comprising%, 2-5% by weight of an acrylic acid polymer partial sodium salt crosslinked product and purified water.

In another aspect of the invention, the present invention consists of a rear layer and an active ingredient-containing matrix layer, the matrix layer is 0.05 ~ 5% by weight, ginseng extract 0.05 ~ 5% by weight, 0.05 ~ 5% by weight lemon extract as an active ingredient , Loquat extract 0.05-5%, seaweed extract 0.05-5%, jujube extract 0.05-5%, raspberry extract 0.05-5%, truemarine 0.05-5%, mugwort powder 5-10%, It consists of 20 ~ 40% by weight of potato starch, 0.01 ~ 0.03% by weight of caffeine, 50 ~ 70% by weight of seawater dry matter, 2 ~ 5% by weight of sodium salt crosslinked acrylic acid polymer, and a mixture of purified water and pressure sensitive adhesive. It is a percutaneous patch for promoting the decomposition and excretion in human fat cells, which is in diffusion communication and adapted to administer the above-mentioned effective ingredient to the skin.

The mechanism of action and the effective ingredient of the present invention will be described in detail.

Adipose cells refer to cells containing a large amount of fat, which are formed as a group following the movement of capillaries as interspersed or plastic connective tissue between fat cell tissues. Intracellular fats initially appear as a few tiny droplets, but they grow larger and merge into one, eventually taking up most of the cell body. Because of this, the intrinsic cytoplasm is pressed together with the nucleus around the cell, leaving it in a crescent form. Lattice fibers are tightly wrapped around fat cells. Intracellular fats are easily detected by Sudan III or osmium tetraoxide.

Adipose cells can be divided into brown adipose cells and white adipose cells. Brown adipocytes are special brown adipose tissues located in the neck and patella of mammals. It is composed of cells full of enemies and rich in sympathetic fibers. It has high metabolic activity, especially lipolysis and fatty acid oxidizing ability, and is considered as an acid heating organ for body temperature control. On the other hand, white fat cells are widely distributed throughout the body and store energy as triglycerides and resupply them as fatty acids as needed. ATP mediated lipolysis

Long chain fatty acids are beta-oxidized to acetyl CoA, completely oxidized in the citric acid cycle and used as an energy source. That is, a significant amount of energy required for metabolism of the liver is obtained by fat burning. Food fat is absorbed by liver cells and oxidized in the mitochondria to produce energy. Fat binds to a carrier called L-carnitine and is transported from the cytoplasm to the liver's mitochondria, which is facilitated by an enzyme called carnitine acyltransferase. Carnitine acyltransferase is inhibited by malonyl-CoA converted from acetyl-CoA. Malonyl-CoA not only inhibits fat burning but also aids in fat synthesis as a precursor to fat and cholesterol synthesis. Acetyl-CoA is synthesized in the mitochondria but must be transported to the cytoplasm to function its biological function, but cannot be transported to the cytoplasm until it is converted to citric acid. That is, the transportable form of acetyl-CoA is citric acid. Seaweed extract of the active ingredient of the present invention was found to be involved in this process.

Therefore, the step of activating a lipase that hydrolyzes triglycerides (glycerol esters) reversibly to the decomposition of fatty acids and glycerol, the fat is transported to the mitochondria and burned through the beta-oxidation reaction of fatty acids to energy By controlling the steps of transporting fat to produce a, transporting the degraded fat into blood vessels, and transporting it to muscles and liver to be used for energy sources and metabolism, it is possible to prevent and treat obesity.

The present invention ginkgo biloba extract, ginseng extract, lemon extract, loquat extract, seaweed extract, jujube extract, raspberry extract, trumarin, mugwort powder, potato starch, caffeine, dried sea salt, acrylic acid polymer part sodium salt crosslinked product It is the invention that was found to be involved in the synthesis, decomposition and excretion process, and was combined.

In particular, the composition of the present invention comprises a component having a cAMP that induces the effect of fat degradation in white adipocytes with ATP mediated lipolysis and a component that assists in the activity of cAMP. Looking specifically at the mechanism, cAMP (cyclic AMP) activates the hormone-sensitive lipase present in the cell, a lipolytic enzyme, and breaks down the fat accumulated in the cell into fatty acids and glycerol. Decomposed fatty acids bind to a protein called albumin in the blood and are transported to the muscles, where they are broken down and excreted again as carbon dioxide and water as energy. Glycerol, on the other hand, is transferred to the liver and metabolized. The composition comprising the active ingredient of the present invention and the patch containing the same efficiently penetrate the cAMP into the body, so that the excess fat in the fat cells is excreted and excreted, resulting in obesity.

In another embodiment of the present invention, by combining the components that make the lipolysis component easier to penetrate, triglycerides are more effectively affected by the compounding components by activating the movement of brown fat cells and promoting the activity of mitochondria in the cells. Decompose

Hereinafter, look at in detail the active ingredients included in the composition of the present invention.

Diet food composition of the present invention to achieve the above object, 0.05 ~ 5% by weight, ginseng extract 0.05 ~ 5%, lemon extract 0.05 ~ 5%, loquat extract 0.05 ~ 5%, seaweed extract as an active ingredient 0.05-5% by weight, Jujube extract 0.05-5%, Raspberry extract 0.05-5%, Trumarin 0.05-5%, Mugwort powder 5.00-10%, Potato starch 20-40%, Caffeine 0.01- 0.03% by weight, seawater dry matter 50-70% by weight, acrylic acid polymer partial sodium salt crosslinked product 2-5% by weight, and the balance comprises purified water.

Among the plants readily available around us, Ginkgo is the only existing species known as Gink-goales that has existed on Earth since the end of Triassic or early Jurassic about 200 million years ago. ) Was also called "living fossil."

Ginko Biloba tree families evolved from ancient fern seeds during the Permian era, where ginkgo biloba and other Ginkgoales disappeared in all regions except East Asia during the 3rd and 4th post-glacial upheavals. It is estimated.

Ginkgo biloba extract has excellent blood flow promoting effect and is effective in improving arteriosclerosis, cerebral atherosclerotic dementia, improving blood pressure, stiff shoulder due to peripheral vascular disorders, cold, lower back pain, stress relief, edema, pain improvement, and PAF ( Platelet Activating Factor).

Ginkgo biloba extract used in the present invention is extracted from Ginko biloba (Ginko biloba), and functions to improve the metabolism in the process of transferring the degraded fatty acids and glycerol to muscle and liver.

Ginseng is a perennial grass belonging to the Ogalpiaceae, and its stem is short, has a node, and is similar to a human figure. Different from the ginseng (Apiaceae) used for food.

Ginseng can treat atherosclerosis and hypertension by increasing the body's defense ability in the state of physical psychiatric function change, and it has tonic effect, and when ginseng is ingested, blood sugar level is decreased, diabetes thirst is quenched, and liver function is caused by liver failure. It is effective in revival, promotes regeneration of damaged liver, has a significant effect on acute alcohol poisoning, promotes skin activity and is particularly effective in acne, blemishes, athlete's foot.

The ginseng extract used in the present invention functions to suppress insulin secretion and lower fat synthesis.

Lemon extract used in the present invention is extracted from the fruit or juice of tangerine and plant lemon. The components include organic acids, flavonoids, essential oils, and the like. The extract contains organic acids such as citric acid and malic acid.

Lemon extract used in the present invention promotes the transfer of degraded fat into blood vessels. It also has the effect of improving edema.

Loquat used in the present invention has been used as a herb since ancient times as an evergreen tree of the Rosaceae family, which is native to China. On the other hand, loquat leaves contain an ingredient called amingdarin, which is effective for diuretic, Jinhae, summer heat, fatigue and appetite. In addition, loquat absorbs fat in the body, which lowers cholesterol levels and increases the amount of bowel movements. The main components of loquat are tannins, saponins, triterpenoids (ursolic acid, oleanolic acid), tartaric acid and malic acid.

Loquat extract used in the present invention promotes the release of fat.

Seaweed extract used in the present invention is extracted from the whole of seaweed algae, especially hibamata which is a seaweed collected from the Voltagne region of France. The component contains polysaccharides, such as arginine acid. Seaweed extract of the present invention is a mixed extract of green algae, crab and red algae having an activating action of lipase. Seaweed extract used in the present invention is extracted by a special extraction method by selecting a seaweed having an activating action of lipase among seaweed collected from all over the world.

Uric acid contained in the seaweed extract activates the lipase, a lipolytic enzyme, to break down fat, thereby producing a reception effect. In addition, the seaweed extract prevents osteoporosis by supplementing calcium released with urea in the diet and is rich in various minerals.

Seaweed extract used in the present invention activates the oxidation of mitochondria in brown adipocytes.

Jujube is the fruit of jujube tree and the tree is native to southeastern Europe and southeastern Asia. Jujube trees are grown mainly near villages. There are thorns on the tree and small thorns are bunched up for nodes. The leaves are alternate, egg-shaped or long egg-shaped, with three leaf veins clearly visible. The upper side of the leaf is light green and slightly polished, and there are fine teeth on the edge of the leaf. There are thorny cotyledons on petioles. Pale yellow-green flowers bloom in June, forming a short inflorescence in the axilla. The calyx petals have 5 stamens and 1 pistil. Fruits are nucleus, oval, reddish brown, glossy. Surgical blood is thin, sticky and sponge-like. The inner skin is hard and has seeds in it and ripens in September.

Jujube extract used in the present invention is extracted from the fruit of jujube, which is a crow mammoth kiwi. Ingredients include vitamin C.

The jujube extract of the present invention functions to accumulate cAMP activating lipase, a lipolytic enzyme, in cells. As a result, lipolysis is promoted.

Raspberry (pronounced raspberry) was known in Europe and North America since prehistoric times, and has been cultivated since the Middle Ages.

Raspberry extract used in the present invention is extracted from the fruit of the rose family raspberry (raspberry). Ingredients include a variety of vitamins, pectin, citric acid and the like. The roots and leaves of raspberry include tannins and flavonoids, and the fruit contains vitamin C, organic acids, sugars and pectins.

Raspberry ketone, a fragrance component of raspberry (Rubus idaeus), acts on lipolytic enzymes.

Artemisia capillaris Thunb used in the present invention is a perennial grass with a height of about 40-100 cm and has an unusual scent. The mugwort contains about 0.27% oil, and it contains fatty acids. Such mugwort has the effect of lowering heat, improving liver function and detoxifying effect, and applying it to skin diseases such as itchy swelling and body, as well as swelling and absorbing by the human body is characterized by well absorbed.

Caffeine used in the present invention transfers excreted fat into blood vessels and has an effect of improving edema.

In another embodiment of the present invention, 0.05-5% by weight ginkgo leaf extract, 0.05-5% by weight ginseng extract, 0.05-5% by weight lemon extract, 0.05-5% by weight loquat extract, 0.05-5% by weight seaweed extract, jujube extract 0.05-5% by weight, Raspberry extract 0.05-5%, Trumarin 0.05-5%, Mugwort powder 5-10%, Potato starch 20-40%, Caffeine 0.01-0.03%, Seawater dried 50- 70 weight%, acrylic acid polymer partial sodium salt crosslinked material, 2-5 weight%, and the remainder provide the patch containing the composition which mix | blended purified water.

The patch of the present invention is a matrix or a structure of a monolithic laminate. Such transdermal patches are well known in the art. They consist of the matrix layer and the back layer of the composition mixed with the pressure sensitive adhesive. The matrix serves both as a composition reservoir and as a means for adhering the patch to the skin. Prior to use, the patch will also include an impermeable release liner layer.

Percutaneous administration of the composition over other methods of administration is that the first-pass effect of drug degradation or metabolism in the liver and gastrointestinal tract can be avoided. As a result, the bioavaility of the composition is increased to avoid side effects caused by unwanted metabolites, and the desired dose of lipolysis and diet (partial reception) can be obtained with low dosage and low frequency. In addition, there is an advantage in that the variation between humans with respect to metabolism can be minimized and the effect of the active ingredient can be enhanced by maintaining a constant concentration of the active ingredient administered in the body.

The back layer is impermeable to the composition and other components of the matrix and defines the top surface of the patch. It may be made of a single layer or film of polymer or may be a laminate of one or more polymer layers and metal foil. Examples of suitable polymers for use in making the back film are polyvinylchloride, polyvinylidene chloride, ethylene-vinylacetate copolymers, polyolefins such as polyethylene and polypropylene, polyurethanes, and polyesters such as polyethylene terephthalate.

The pressure sensitive adhesive of the matrix will usually be solution polyacrylate, silicone, or polyisobutylene (PIB). Such adhesives are well known in the transdermal art. See, for example, Handbook of Prossure Sensitive Adhesive Technology, 2nd Edition (1989) Van Nostrand, Reinhold.

Pressure sensitive solution polyacrylate adhesives are obtained by copolymerizing one or more acrylic monomers (“acrylates” includes both acrylates and methacrylates), one or more modified monomers, and one or more functional group-containing monomers in an organic solvent. Is made. The acrylate monomers used to make these polymers are usually alkyl acrylates of 4-17 carbon atoms, with 2-ethylhexyl acrylate, butyl acrylate, and isooctyl acrylate being preferred. Modified monomers are typically included to alter the Tg of the polymer. Such monomers such as vinyl acetate, ethyl acrylate and methacrylate, and methyl methacrylate are useful for this purpose. The functional group containing monomers provide sites for crosslinking. The functional groups of these monomers are preferably carboxyl, hydroxy or combinations thereof. Examples of monomers providing such groups are hydroxy containing monomers such as acrylic acid, methacrylic acid and hydroxyethyl acrylate. Polyacrylate adhesives are preferably crosslinked using crosslinking agents to improve their physical properties (eg, slip and fall resistance). The crosslink density should be low because high crosslinking adversely affects the adhesion of the polymer. Examples of crosslinking agents are disclosed in US Pat. No. 5,393,529. Solution polyacrylate pressure sensitive adhesives are commercially available from 3M under the trade names GELVA ^™ and DURO-TAK ^™ .

Polyisobutylene adhesives are a mixture of high molecular weight (HMW) PIB and low molecular weight (LMW) PIB. Such mixtures are described in the art, for example in PCT / US91 / 02516. The molecular weight of the HMW PIB will usually range from about 700,000 to 2,000,000 Da, while the molecular weight of the LMW PIB will typically range from 35,000 to 60,000. Molecular weights mentioned herein are weight average molecular weights. The weight ratio of HMW PIB to LMW PIB in the adhesive will usually range from 1: 1 to 1:10. PIB adhesives will also include high viscosity Tg low molecular weight aliphatic resins, such as viscosity additives such as polybutene oil, and ESCOREZ ^™ resins, purchased from Exxon Chemical, which is purchased from Exxon Chemical. Polyisobutylene polymers are commercially available from Exxon Chemical under the trade name VISTANEX ^™ .

Silicone adhesives that can be used to form the matrix are typically high molecular weight polydimethylsiloxanes or polydimethyldiphenyl siloxanes. Formulations of silicone adhesives used in transdermal preparations are described in US Pat. Nos. 5,232,702, 4,906,169, and 4,951,622.

In addition to pressure sensitive adhesive active ingredients, matrices typically use absorption accelerators to enhance the penetration of the active ingredient through the skin, such as fatty acid esters and fatty acids of alkanediol of C ₂ -C ₄ in US Pat. No. 4,906,463. Alcohol ethers were used, oleic acid and propylene glycol in European Patent Application No. 430,491, polyethylene ester or polysorbate 80 in European Patent Application No. 328,806, and propylene glycol monolaulysopropyl, iso; in US Patent No. 4,973,468 Butyl alcohol was used, and US Pat. No. 4,438,139 used polyvinylpyrrolidone, polyvinyl alcohol, and glycerol in combination. In addition, US Pat. No. 5,122,383 used sorbitan esters as absorption accelerators. The amount of absorption accelerator included in the matrix will depend on the specific promoter used. In most cases, the accelerator will then constitute a range of 1-20% by weight of the matrix.

The matrix may contain the following additives depending on the specific adhesive used. For example, a material such as polyvinylpyrrolidone (PVP) that inhibits drug crystallization, an absorbent that improves wear duration, or the physical properties of the matrix (eg, cold flow) or adhesion (eg, Adhesives may be included to improve stickiness, cohesive strength).

The patch of the invention may also be prepared using procedures known in the art of transdermal patches. The process generally involves preparing the matrix (ie, mixing the adhesive, drug, penetration enhancer, and additives if any), casting the matrix to the backing or release liner layer, removing the solvent from the matrix and optionally It will involve applying a back / release liner layer. As will be apparent to those skilled in the art, matrix compositions having an effective amount of components dispersed therein can be included in various transdermal configurations and thus the applicant is not limited to the embodiments illustrated below.

(Example)

Preparation of the Compositions of the Invention

30 g of ginkgo biloba was taken, chopped, and extracted with 50 ml of methanol and 50 ml of ethanol, respectively, and methanol in the extraction solvent was first volatilized and then ethanol was volatilized. The obtained ginkgo leaf extract was made into the ginkgo leaf extract based on 50% 1, 3- butylene glycol. 30 g of ginseng was chopped, finely immersed in 100 ml of 50% ethanol and extracted for one day. The obtained ginseng extract was used as a ginseng extract based on 50% 1,3-butylene glycol. 30 g of lemon fruit was taken, chopped, and extracted with ethanol, which was then used as a lemon extract based on 1,3-butylene glycol. Pick fresh leaves of the loquat, wash them thoroughly, drain the water, and dry in the shade for about 3 days. Take 100 g of dried loquat, immerse in 50% ethanol to obtain a loquat extract. Seaweed extract is composed of 1,3-butylene glycol, water, brown algae extract, red algae extract and green algae extract, in the present embodiment Algelix as seaweed extract Was used. Jujube was used as fruit of zizyphus jujuba, 30g of fruit was taken, and extracted with ethanol. As the base of the jujube extract, all of 50% ethanol, 1,3-butylene glycol and 30% ethanol can be used. In this embodiment, jujube extract based on 50% ethanol is used. The raspberry extract used to extract the raspberry with an appropriate amount of ethanol, the final component was used to adjust the total composition of the raspberry extract 1.20%, BG 48.80% and purified water 50.00%. The seawater dried water was separated from water and concentrate using a reverse immersion membrane. The reverse immersion membrane separator used Toray Industries, Ltd., and concentrated the seawater up to 2 times. The composition of seawater and concentrated seawater used for separation is as follows.

Composition of Seawater and Concentrated Seawater unit sea water Concentrated water Na % 1.03 2.11 Mg % 0.12 0.24 Ca ppm 356.4 717.6 Cl % 2.25 4.14 SO ₄ % 0.31 0.67 K ppm 449.9 800

The seawater dry matter having the above composition was used as the seawater dry matter in the present invention. Trumarin, mugwort powder and potato starch, and other ingredients are commercially available and used without change. After the raw material of the above composition was prepared, the composition of this invention was prepared as follows.

0.1% by weight of ginkgo biloba extract based on 50% 1,3-butylene glycol, 0.1% by weight of ginseng extract based on 50% ethanol, and 50% by weight of lemon extract based on 1,3-butylene glycol , 0.1% by weight of 50% ethanol based loquat extract, 0.1% by weight of seaweed extract based on 1,3-butylene glycol, 0.1% by weight of 50% ethanol based extract, 50% 1,3- Raspberry extract based on butylene glycol 0.1% by weight, Trumarin 0.1% by weight 5, mugwort powder 6.00% by weight, potato starch 30.00% by weight, caffeine 0.01% by weight, sea water dry 60.19% by weight, acrylic acid polymer partial sodium salt crosslinked product 3.00 wt% and purified water are mixed and stirred to form a composition of the present invention.

Example 2

Preparation of the patch of the present invention

The composition prepared in Example 1 was prepared in the form of a patch. First, polyacrylate is applied as an adhesive on a support composed of ethylene-vinyl acetate copolymer and aluminum laminate. In the application of the pressure-sensitive adhesive, so-called calender method was used, and the pressure-sensitive adhesive was applied onto the support using a calender roll. A matrix layer was provided on the pressure-sensitive adhesive layer, and the composition of Example 1 was applied to the matrix layer by a fusion method.

Example 3

Clinical trial

In order to determine the effect of the composition prepared according to the present invention and a patch containing the same, a clinical experiment was conducted as follows.

The average obesity was 131% and the average BMI was 26, 45 adult men and women over 20 years old. The patch according to the present invention was applied to the abdomen for 30 days. Then, using the inbody body composition analyzer, the body fat percentage, abdominal fat percentage, weight, BMI and other items were examined to examine the changes before and after attachment.

Body fat, body fat percentage and abdominal fat percentage decreased significantly (P (0.05)) after application of the patch of the present invention as shown in Table 2, and the body fat decreased on average about 2kg from 17.4kg to 15.6kg. Abdominal fat decreased from 29.3% to 27.2% from 0.83 to 0.81.

Body fat analysis result before (n = 45) after (n = 45) F-value Fat 17.4 ± 0.60 15.6 ± 0.59 1.03 ^NS Percent body fat 29.3 ± 0.69 27.2 ± 0.69 1.01 ^NS WHR 0.83 ± 0.01 0.81 ± 0.01 1.07 ^NS

Body weight and body index showed a tendency to decrease slightly after attachment compared to before applying the patch formulated with the composition of the present invention as shown in Table 2, but there was no significance. On average, body weight decreased by 5 kg from 58.9 kg to 56.6 kg, and body index decreased from 22.4 to 21.6.

Body weight and body size analysis before (n = 45) after (n = 45) F-value weight 58.9 ± 0.86 56.6 ± 0.84 1.05 ^NS BMI 22.4 ± 0.31 21.6 ± 0.30 1.03 ^NS

As can be seen through the above examples and clinical experiments, the composition according to the present invention and the transdermal administration patch comprising the same, as well as the effect of weight loss, the imbalance of the body that can come in fasting and low calorie and the like and It maintains the physiological activity and function of the human body by suppressing the yo-yo phenomenon after dieting, and did not cause side effects such as headache, insomnia, blood pressure rise, nervousness, nervousness, hallucinations, dizziness, and decreased vision, and increased physiological activity of the body. It can be seen that the action is certain.

In addition, since the composition is administered in diffusion communication with human skin, it has a particularly significant effect on local reception.

Those skilled in the art will appreciate that various changes and modifications can be made without departing from the technical spirit of the present invention. Therefore, the technical scope of the present invention should not be limited to the contents described in the detailed description of the specification but should be defined by the claims.

Claims (5)

To a diet containing ginkgo biloba extract, ginseng extract, lemon extract, loquat extract, seaweed extract, jujube extract, raspberry extract, truemarine, mugwort powder, potato starch, caffeine, seawater dried matter, acrylic acid polymer part sodium salt crosslinked product and purified water Useful compositions. According to claim 1, wherein the composition is 0.05-5% by weight of ginkgo leaf extract, 0.05-5% by weight ginseng extract, 0.05-5% by weight lemon extract, 0.05-5% by weight loquat extract, 0.05-5% by weight seaweed extract, jujube Extract 0.05 ~ 5%, Raspberry Extract 0.05 ~ 5%, Trumarin 0.05 ~ 5%, Mugwort Powder 5 ~ 10%, Potato Starch 20-40%, Caffeine 0.01 ~ 0.03%, Seawater Dried 50 A composition useful for a diet comprising 70 wt%, 2-5 wt% of an acrylic acid polymer partial sodium salt crosslinked product and purified water. The composition useful for a diet according to claim 1 or 2, which is a composition for transdermal administration. a) the back layer and b) consisting of a matrix layer underlying the backing layer, The matrix layer consists of ginkgo biloba extract, ginseng extract, lemon extract, loquat extract, seaweed extract, jujube extract, raspberry extract, truemarine, mugwort powder, potato starch, caffeine, seawater dry matter, acrylic acid polymer part sodium salt crosslinked material and purified water and pressure Consisting of a mixture of sensitizers and in diffusion communication with human skin and adapted to administer the composition, Useful patch for diet in a person. The method of claim 4, wherein the matrix layer is 0.05-5% by weight of ginkgo leaf extract, 0.05-5% by weight ginseng extract, 0.05-5% by weight lemon extract, 0.05-5% by weight loquat extract, 0.05-5% by weight seaweed extract, jujube Extract 0.05 ~ 5%, Raspberry Extract 0.05 ~ 5%, Trumarin 0.05 ~ 5%, Mugwort Powder 5 ~ 10%, Potato Starch 20-40%, Caffeine 0.01 ~ 0.03%, Seawater Dried 50 A patch useful for a diet, characterized in that it contains ˜70% by weight, acrylic acid polymer partial sodium salt crosslinked material, 2-5% by weight, and purified water.